2,463 results match your criteria Current opinion in cardiology[Journal]


cGMP manipulation in cardiometabolic disease: chances and challenges.

Curr Opin Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany.

Purpose Of Review: Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system.

Recent Findings: Recent studies suggest that cGMP, which serves as second messenger for nitric oxide and for natriuretic peptides, improves oxidative metabolism and insulin signaling. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000630DOI Listing
April 2019
1 Read

Polygenic risk scores in coronary artery disease.

Curr Opin Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California, USA.

Purpose Of Review: Large genome-wide association studies (GWAS) have identified variants accounting for a substantial portion of the heritable risk for coronary artery disease (CAD). These studies have not only catalyzed drug discovery but also have opened the possibility of improved risk prediction and stratification. Here we review the current state-of-the art in polygenic risk scores (PRSs) and look to the future, as these scores move towards clinical application. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000629DOI Listing
April 2019
2 Reads

Multiomic approaches to delineate the pathogenesis of cardiac disease.

Authors:
Scot J Matkovich

Curr Opin Cardiol 2019 May;34(3):246-253

Diabetes and Complications Research, Eli Lilly and Company, Indianapolis, USA.

Purpose Of Review: Comprehensive analyses of the genome, transcriptome, proteome and metabolome are instrumental in identifying biomarkers of disease, to gain insight into mechanisms underlying the development of cardiovascular disease, and show promise for better stratifying patients according to disease subtypes. This review highlights recent 'omics' studies, including integration of multiple 'omics' that have advanced mechanistic understanding and diagnosis in humans and animal models.

Recent Findings: Transcriptome-based discovery continues to be a primary method to obtain data for hypothesis generation and the understanding of disease pathogenesis has been enhanced by single cell-based methods capable of revealing heterogeneity in cellular responses. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000611DOI Listing

Adriamycin-associated cardiomyopathy: where are we now? updates in pathophysiology, dose recommendations, prognosis, and outcomes.

Authors:
Brian W Hardaway

Curr Opin Cardiol 2019 May;34(3):289-295

Department of Cardiovascular Disease, Mayo Clinic, Phoenix, Arizona, USA.

Purpose Of Review: Advances in cancer treatments have resulted in significant improvements in survival. Anthracycline chemotherapeutics play a major role in the treatment of hematologic malignancies and solid tumors; however, there is a risk of anthracycline cardiomyopathy in survivors. This focused review will provide a historical context on anthracycline cardiomyopathy and will also review pathophysiologic mechanisms of cardiotoxicity, dosage recommendations, prognosis, and outcomes. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000617DOI Listing

Epigenetics in dilated cardiomyopathy.

Curr Opin Cardiol 2019 May;34(3):260-269

Departments of Anesthesiology, Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, California, USA.

Purpose Of Review: Characterized by enlarged ventricle and loss of systolic function, dilated cardiomyopathy (DCM) has the highest morbidity among all the cardiomyopathies. Although it is well established that DCM is typically caused by mutations in a large number of genes, there is an emerging appreciation for the contribution of epigenetic alteration in the development of DCM.

Recent Findings: We present some of the recent progress in the field of epigenetics in DCM by focusing on the four major epigenetic modifications, that is, DNA methylation, histone modification, chromatin remodeling as well as the noncoding RNAs. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000616DOI Listing
May 2019
2 Reads

Mean platelet volume and coronary artery disease.

Curr Opin Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

Purpose Of Review: To critically review the literature describing links between mean platelet volume (MPV) and cardiovascular disease (CVD). We will focus on coronary artery disease (CAD). The MPV is measured routinely as part of a routine blood count. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000624DOI Listing
April 2019
2.696 Impact Factor

Hyperuricaemia and vascular risk: the debate continues.

Curr Opin Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy.

Purpose Of Review: To update the evidence about the role of elevated levels of uric acid as a risk factor for cardiovascular disease. The review includes the most recent epidemiological evidence as well as the possible mechanisms supporting the interaction between uric acid and cardiovascular, metabolic and renal disease.

Recent Findings: The confirmed role of uric acid as involved in the onset and progression of cardiovascular and metabolic diseases. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000626DOI Listing
March 2019
1 Read

Immune checkpoint inhibitor myocarditis.

Curr Opin Cardiol 2019 May;34(3):303-306

Division of Cardiology, University of Chicago, Chicago, Illinois, USA.

Purpose Of Review: The purpose of this study is to summarize and highlight the recent literature regarding immune checkpoint inhibitor myocarditis.

Recent Findings: The use of immune checkpoint inhibitors, a promising form of immunotherapy, is rapidly increasing in oncology. These drugs have been recently found to cause a fulminant myocarditis associated with a high-case fatality rate. Read More

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http://Insights.ovid.com/crossref?an=00001573-900000000-9910
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http://dx.doi.org/10.1097/HCO.0000000000000622DOI Listing
May 2019
4 Reads

Editorial: Highlights from the emerging field of cardio-oncology.

Curr Opin Cardiol 2019 May;34(3):282

Department of Medicine, Division of Cardiology, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1097/HCO.0000000000000618DOI Listing

Risk factors for chemotherapy-related cardiac toxicity.

Curr Opin Cardiol 2019 May;34(3):283-288

Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA.

Purpose Of Review: The purpose of this review is to discuss the clinical and treatment-related factors that increase the risk of cardiotoxicity with anthracyclines and human epidermal growth factor 2 receptor inhibitors.

Recent Findings: Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy. Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000619DOI Listing
May 2019
2 Reads

Noncoding RNAs in cardiovascular diseases.

Authors:
Priyatansh Gurha

Curr Opin Cardiol 2019 May;34(3):241-245

Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Texas, USA.

Purpose Of Review: Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function. Read More

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http://Insights.ovid.com/crossref?an=00001573-900000000-0000
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http://dx.doi.org/10.1097/HCO.0000000000000615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459692PMC
May 2019
2 Reads

Treatment of chemotherapy-associated cardiomyopathy.

Curr Opin Cardiol 2019 May;34(3):296-302

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose Of Review: The number of cancer survivors is increasing, and cardiovascular events are a significant cause of morbidity and mortality in these patients. Preexisting cardiovascular conditions as well as the development of cancer therapeutics-related cardiac dysfunction (CTRCD), in particular left ventricular dysfunction and heart failure, limit the options for cancer therapies for these patients and contribute to reduced cancer survival.

Recent Findings: Recent guidelines and position statements from various cardiology and oncology societies provide an outline for the practicing physician for the management of CTRCD. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000614DOI Listing
May 2019
7 Reads

Telomere length and cardiovascular disease risk.

Curr Opin Cardiol 2019 May;34(3):270-274

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Purpose Of Review: Telomere length has been hypothesized as a putative biomarker for cardiovascular disease. However, the findings are mixed and shared confounding factors may explain these associations. The current review aims to summarize the recent literature on the role of telomere length in cardiovascular disease and give directions for future potential as a predictive biomarker. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000613DOI Listing

Sex differences in hypertrophic cardiomyopathy: new insights.

Curr Opin Cardiol 2019 May;34(3):254-259

Department of Physiology, Amsterdam University Medical Center, Location VUmc, Amsterdam.

Purpose Of Review: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, diagnosed by left ventricular hypertrophy of at least 15 mm maximal wall thickness (MWT). Recent studies reported a sex difference in clinical presentation, progression and outcome of HCM. This review provides an overview of recent studies into sex differences in HCM. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000612DOI Listing
May 2019
6 Reads

Genetics of atrial cardiomyopathy.

Curr Opin Cardiol 2019 May;34(3):275-281

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst.

Purpose Of Review: Atrial cardiomyopathy is a frequently encountered but underappreciated clinical entity that is characterized by altered atrial size and function. Although traditionally considered a primary atrial disorder, atrial cardiomyopathy was recently redefined to include secondary atrial remodelling. This conceptual shift has implications for the scope of etiological factors and intervention strategies. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000610DOI Listing
May 2019
8 Reads

Predicting the future of TAVR: an obituary to open aortic valve replacement?

Curr Opin Cardiol 2019 Mar;34(2):112-123

Department of Cardiovascular Surgery, Mount Sinai Health System. New York, New York.

Purpose Of Review: Transcatheter aortic valve replacement (TAVR) has become the cornerstone for aortic valve intervention since the first implantation in 2002. Recent advances with novel devices and introduction into lower risk cohorts have been successful. In this review, we discuss the ongoing limitations to transcatheter aortic valve therapy and whether it will replace surgical aortic valve replacement in the foreseeable future. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000609DOI Listing
March 2019
4 Reads

Transcatheter tricuspid valve intervention: a practical algorithm for patient selection.

Curr Opin Cardiol 2019 Mar;34(2):164-172

Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

Purpose Of Review: Worldwide experience in transcatheter tricuspid valve intervention is increasing as more options become available for the treatment of severe tricuspid regurgitation. These devices can be categorized by their primary mechanism of action, including edge-to-edge leaflet devices, space occupying devices, annuloplasty devices, complete valve replacement and caval valve implantation. This review summarizes the current technologies in use, early clinical results and factors that may affect procedural success. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000607DOI Listing
March 2019
14 Reads

Mechanical circulatory support in the heart failure population.

Curr Opin Cardiol 2019 Mar;34(2):194-201

Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Purpose Of Review: Use of durable left ventricular assist devices (LVADs) has increased considerably in recent years because of the insufficient supply of donor hearts for cardiac transplantation and improvement in outcomes from refinements in technology. This review examines clinical utility of these devices and summarizes the most recent evidence supporting the use of LVAD therapy.

Recent Findings: There continues to be significant advancements made in LVAD technology, which has resulted in improvements in the rates of adverse events and overall patient quality of life. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000600DOI Listing
March 2019
23 Reads

Clinical application of echocardiographic-derived myocardial strain imaging in subclinical disease: a primer for cardiologists.

Curr Opin Cardiol 2019 Mar;34(2):147-155

Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

Propose Of Review: To highlight the evidence to support the measurement of left ventricular (LV) global longitudinal strain (GLS) in the risk assessment and management of patients with valvular heart disease.

Recent Findings: Subclinical myocardial dysfunction that is characterized by impaired LV GLS is often present in patients with valvular disease. The addition of GLS to the LV systolic function assessment refines disease classification and improves both prognosis and management of valvular disease. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000592DOI Listing
March 2019
5 Reads

Cardiovascular complications following pneumonia: focus on pneumococcus and heart failure.

Curr Opin Cardiol 2019 Mar;34(2):233-239

Faculty of Health and Medical Sciences, Medical School, The University of Western Australia, Perth.

Purpose Of Review: Pneumonia, an inflammatory disease, is the single largest infectious cause of death. Pneumonia has recently been established as an important contributing factor to major adverse cardiovascular events including heart failure. Developing an intermechanistic understanding of pneumonia and cardiovascular disease is crucial for successful future drug therapy and reducing healthcare expenditure. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000604DOI Listing
March 2019
23 Reads

Biomarker developments in heart failure: 2016 and beyond.

Curr Opin Cardiol 2019 Mar;34(2):218-224

Division of Cardiology, University of California, San Diego, La Jolla, California, USA.

Purpose Of Review: Biomarkers play a fundamental role in the management of heart failure. Both new and old biomarkers are evaluated every year with new information gained for their use in heart failure. Major advancements have been made in the past 2 years in key biomarkers that will surely become part of standard clinical management of heart failure. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000596DOI Listing
March 2019
1 Read

Utilizing wall shear stress as a clinical biomarker for bicuspid valve-associated aortopathy.

Curr Opin Cardiol 2019 Mar;34(2):124-131

Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta.

Purpose Of Review: Bicuspid aortic valve (BAV) results from fusion of two adjacent aortic valve cusps, and is associated with dilatation of the aorta, known as BAV-associated aortopathy, or bicuspid aortopathy. Bicuspid aortopathy is progressive, increasing the risk of life-threatening clinical events, such as aortic dissection. Regular monitoring and timely intervention with prophylactic surgical resection of the proximal aorta is recommended. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365179PMC
March 2019
6 Reads
2.696 Impact Factor

Treatment of diabetes and heart failure: a paradigm shift for cardiologists?

Curr Opin Cardiol 2019 Mar;34(2):207-212

CK Hui Heart Centre, Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, Canada.

Purpose Of Review: Diabetes is a well-recognized risk factor for the development of cardiovascular disease. In recent years, several new glucose-lowering drugs (GLD) have shown improvements in cardiovascular outcomes, renewing interest of cardiovascular specialists in diabetes management.

Recent Findings: Individual studies in the last 5 years have demonstrated the cardiovascular safety of certain dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 agonists, and sodium glucose cotransporter 2 inhibitors. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000599DOI Listing
March 2019
21 Reads

PALMD as a novel target for calcific aortic valve stenosis.

Curr Opin Cardiol 2019 Mar;34(2):105-111

Institut Universitaire de Cardiologie et de Pneumologie de Québec.

Purpose Of Review: Novel medical treatments are urgently needed to stem the escalating socioeconomic burden of calcific aortic valve stenosis (CAVS). Herein, we describe the discovery of PALMD as a disease-causing gene for CAVS and discuss its implications for the understanding of disease pathogenesis and the development of new treatment options.

Recent Findings: Large-scale genomic approaches are finally starting to yield genetic loci robustly associated with CAVS. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000605DOI Listing
March 2019
5 Reads

The more you look, the more you find: atrial fibrillation - nowhere to hide.

Curr Opin Cardiol 2019 Mar;34(2):140-146

Department of Surgery, University of Toronto.

Purpose Of Review: We provide an updated review on the incidence of postoperative atrial fibrillation (POAF) after cardiac surgery as determined by enhanced cardiac rhythm monitoring technology and provide a rationale for why a more aggressive detection approach for POAF may be clinically useful.

Recent Findings: Most of the published literature had focused on the in-hospital incidence of POAF after cardiac surgery. However, recent studies using continuous cardiac rhythm technologies revealed that the incidence of POAF during the postdischarge, subacute (<1 month) phase could be as high as 28%. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000591DOI Listing
March 2019
1 Read

Late deaths after Fontan procedure: the next frontier.

Curr Opin Cardiol 2019 Mar;34(2):156-163

Division of Cardiovascular Surgery, Labatt Family Heart Centre, The Hospital for Sick Children.

Purpose Of Review: It has been more than 4 decades since the development of Fontan operation. With the contemporary surgical strategies to treat the patients with a single ventricle physiology, the medium-term survival of the patients following Fontan operation is excellent. Nonetheless, the Fontan circulation with a pumpless pulmonary circulation has fundamental physiologic limitations, which are associated with late Fontan failure and deaths. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000603DOI Listing
March 2019
14 Reads

Early failure of aortic bioprostheses: what are the mechanisms?

Curr Opin Cardiol 2019 Mar;34(2):173-177

Division of Cardiac Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: The purpose of this study is to review the contemporary evidence surrounding aortic bioprosthetic valve deterioration, with a focus on early failure of surgically implanted valves.

Recent Findings: Structural valve deterioration (SVD) remains the most frequent cause of premature bioprosthetic aortic valve failure. However, recent evidence suggests that SVD represents a spectrum, and that clinically silent hemodynamic valve deterioration frequently precedes and predisposes to overt SVD. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000602DOI Listing
March 2019
2 Reads

Secondary mitral regurgitation: percutaneous edge-to-edge repair on the cutting edge?

Curr Opin Cardiol 2019 Mar;34(2):185-193

Division of Cardiology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Purpose Of Review: Secondary mitral regurgitation commonly complicates heart failure. Although the evidence for its management is most robust for treating the underlying cardiomyopathy, treatment aimed at additionally reducing the severity of mitral regurgitation with a percutaneous edge-to-edge device, MitraClip, has recently emerged.

Recent Findings: Despite the use of contemporary evidence-based heart failure therapies, patients with secondary mitral regurgitation and heart failure continue to remain at high risk for adverse clinical events; in both the MITRA-FR and COAPT trials, an extremely high event rate was evident in the medically managed arms over the respective 12-24-month follow-up. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000593DOI Listing
March 2019
26 Reads
2.696 Impact Factor

The gut microbiome and heart failure.

Curr Opin Cardiol 2019 Mar;34(2):225-232

Medical School, The University of Western Australia, Perth.

Purpose Of Review: The human gut is populated by a complex community of microbiota that coexists with the host to maintain homeostasis. Accumulating evidence shows that changes in the composition and diversity of gut microbiota, known as dysbiosis, is associated with cardiovascular diseases, such as atherosclerosis, hypertension, and heart failure.

Recent Findings: Although recent advances in biochemical and molecular analyses have contributed to the detection, identification, and characterization of a variety of gut microbiota genomes and their associated metabolites, the exact mechanisms of action remain unclear. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000598DOI Listing
March 2019
1 Read

Right ventricular failure management.

Curr Opin Cardiol 2019 Mar;34(2):213-217

Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada.

Purpose Of Review: Review recent advances in the diagnosis and management of right ventricular (RV) failure.

Recent Findings: Temporary and durable device-based management of RV failure has emerging applications.

Summary: Research advances and clinical management in RV failure have been limited by a lack of consensus on a universal definition. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000595DOI Listing
March 2019
2 Reads

Biomarkers of aortic bioprosthetic valve structural degeneration.

Curr Opin Cardiol 2019 Mar;34(2):132-139

Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Québec, Canada.

Purpose Of Review: Bioprosthetic valves are now used for the majority of surgical aortic valve replacements and for all transcatheter aortic valve replacements. However, bioprostheses are subject to structural valve deterioration (SVD) and have, therefore limited durability.

Recent Findings: Clinical, imaging, and circulating biomarkers may help to predict or indicate the presence of bioprosthetic valve SVD. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000590DOI Listing
March 2019
2 Reads

Update on the diagnosis and management of acute heart failure.

Curr Opin Cardiol 2019 Mar;34(2):202-206

Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton.

Purpose Of Review: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.

Recent Findings: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000594DOI Listing
March 2019
2 Reads

COMPASS for Vascular Surgeons: Practical Considerations.

Curr Opin Cardiol 2019 Mar;34(2):178-184

Department of Surgery, University of Toronto.

Purpose Of Review: To suggest a practical approach for the application of data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial in patients with peripheral artery disease (PAD).

Recent Findings: The COMPASS trial showed that low-dose rivaroxaban 2.5 mg twice daily plus daily aspirin was superior to aspirin alone in reducing major adverse cardiovascular and cerebrovascular events, and major adverse limb events among patients with stable atherosclerotic vascular disease, including those with PAD. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000597DOI Listing
March 2019
6 Reads

Ablation of persistent atrial fibrillation and beyond.

Curr Opin Cardiol 2019 Jan;34(1):16-22

Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital.

Purpose Of Review: Percutaneous catheter ablation is an effective treatment for atrial fibrillation. However, catheter ablation for the treatment of persistent atrial fibrillation or long-standing persistent atrial fibrillation is associated with unsatisfying success rates. This review aims to summarize the recent literature on the progress of catheter ablation among patients with persistent atrial fibrillation RECENT FINDINGS: In this review, we outline the potential future therapeutic techniques of catheter ablation of persistent atrial fibrillation. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000575DOI Listing
January 2019
2 Reads

Catheter ablation in elderly patients: a review of current studies and pending questions.

Curr Opin Cardiol 2019 Jan;34(1):29-34

Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.

Purpose Of Review: Catheter ablations are established treatment options for cardiac arrhythmias. Despite the fact that they are increasingly performed in elderly patients, publications focusing on procedural safety and success concerning this patient subgroup are sparse. The purpose of this review is to inform about current and upcoming studies regarding catheter ablations in the elderly. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000579DOI Listing
January 2019
34 Reads

Comparing radiofrequency and cryoballoon technology for the ablation of atrial fibrillation.

Curr Opin Cardiol 2019 Jan;34(1):1-5

Banner University Medical Center Phoenix Heart Institute, Phoenix.

Purpose Of Review: With the growing popularity of the cryoballoon tool for catheter ablation of atrial fibrillation, there has been discussion of whether cryothermal energy is just as or more effective than traditional radiofrequency. This review will compare both thermal energies for the treatment of atrial fibrillation.

Recent Findings: Although the FIRE and ICE trial established that cryoballoon technology is noninferior to radiofrequency ablation for the treatment of atrial fibrillation, both thermal technologies have undergone advancement. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000578DOI Listing
January 2019
42 Reads

Talent alone is not enough: lessons learned in a decade as chief.

Authors:
Alan H Friedman

Curr Opin Cardiol 2019 Jan;34(1):87-93

Yale Pediatric Cardiology, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA.

Purpose Of Review: In this review, we explore the change in what is required for outstanding and successful clinical practice and the challenges of putting our teams in positions to succeed.

Recent Findings: We review the benefits of sleep in the training of physicians, acknowledge the science and practice of quality, safety, professionalism and communication in clinical practice.

Summary: The talented physician has more than scientific knowledge and technical expertise; they must incorporate a commitment to patient safety, personal and colleague well being and a culture that is built on values of professional behavior. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000585DOI Listing
January 2019
19 Reads

Advances in fetal echocardiography: myocardial deformation analysis, cardiac MRI and three-dimensional printing.

Curr Opin Cardiol 2019 Jan;34(1):35-40

MEDNAX, Fairfax, Virginia, USA.

Purpose Of Review: Advances in ultrasound technology have led to new ways of evaluating cardiac function and structure, including myocardial deformation imaging (strain and strain rate), cardiac MRI and three-dimensional (3D) printing. As ultrasound technology has improved, it has become possible to use these modalities to evaluate the fetal heart. This article will review some of the more recent developments in applying these techniques to the evaluation of fetal cardiac structure and function. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000584DOI Listing
January 2019
18 Reads

Long-lasting benefits of exercise for those living with a Fontan circulation.

Curr Opin Cardiol 2019 Jan;34(1):79-86

Heart Research Group, Murdoch Children's Research Institute.

Purpose Of Review: In recent decades, the physiology and late outcomes of the Fontan circulation have become better characterized and interest has turned to interventions that might improve exercise capacity and clinical sequelae. No therapy has currently been shown to be more effective for improving exercise capacity in the setting of a Fontan circulation than exercise. This review examines the current evidence supporting exercise as therapy for this group. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000582DOI Listing
January 2019
22 Reads

Cryoballoon ablation beyond paroxysmal atrial fibrillation.

Curr Opin Cardiol 2019 Jan;34(1):23-28

Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.

Purpose Of Review: Although radiofrequency-based pulmonary vein isolation (PVI) was considered the 'gold standard' for the treatment of atrial fibrillation for a long time, the cryoballoon has turned out to be a common alternative tool for atrial fibrillation ablation. Most of the data regarding cryoballoon-based ablation relate to patients with paroxysmal atrial fibrillation (PAF). In this review, we summarize recent knowledge on the usage of cryoballoon ablation for other conditions, especially persistent atrial fibrillation. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000573DOI Listing
January 2019
1 Read

Imaging the itis: endocarditis, myocarditis, and pericarditis.

Curr Opin Cardiol 2019 Jan;34(1):57-64

Division of Cardiology, Heart Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Inflammatory and/or infectious conditions affecting the heart and pericardium in children are primarily diagnosed via noninvasive imaging modalities. In addition, the use of multiple imaging modalities (multimodality imaging) is becoming increasingly common to assist in diagnosis, management, and prognosis. This review focuses on the use of noninvasive imaging in endocarditis, myocarditis, and pericarditis, with emphasis placed on the use of echocardiography and cardiac MRI in these conditions. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000577DOI Listing
January 2019
2 Reads

Avoiding physician burnout through physical, emotional, and spiritual energy.

Authors:
Sharon Karr

Curr Opin Cardiol 2019 Jan;34(1):94-97

Pediatric Cardiology Associates, Fairfax, Virginia, USA.

Purpose Of Review: The purpose of this review is to update the physician community on current evidence regarding ways individuals can combat the rise in physician burnout. More than half of US physicians are experiencing at least some degree of burnout and the incidence has increased significantly over the past decade.

Recent Findings: Recent findings suggest practicing physical, mental, and emotional self-care are important factors in avoiding physician burnout. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000574DOI Listing
January 2019
21 Reads

Frequent premature ventricular beats in healthy children: when to ignore and when to treat?

Authors:
Mitchell I Cohen

Curr Opin Cardiol 2019 Jan;34(1):65-72

Children's Heart Center, Pediatric Electrophysiology, Inova Fairfax Children's Hospital, Falls Church, VA, USA.

Purpose Of Review: Premature ventricular beats (PVCs) are frequently identified in healthy children with structurally normal hearts and generally have a benign clinical course often disappearing spontaneously. However, a small percentage of children may develop a cardiomyopathy. The purpose of this review is to understand which children may be at risk of development of left ventricular (LV) dysfunction with idiopathic PVCs. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000581DOI Listing
January 2019
26 Reads

The importance of genetics and genetic counselors in the evaluation of patients with bicuspid aortic valve and aortopathy.

Curr Opin Cardiol 2019 Jan;34(1):73-78

Inova Children's Hospital.

Purpose Of Review: Bicuspid aortic valve (BAV) is a common congenital heart defect, with an estimated frequency of 1-2% in the general population. BAV may occur as an isolated finding or as a feature of certain syndromes. This article discusses potential genetic causes of BAV, includes a list of current known and candidate genes associated with BAV, provides a hypothetical case demonstrating the importance of genetic testing and cascade screening, and highlights the value of genetic counselors specializing in cardiovascular genetics. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000586DOI Listing
January 2019
24 Reads

Management strategies for the preemie ductus.

Curr Opin Cardiol 2019 Jan;34(1):41-45

Division of Neonatology, Cook Children's Medical Center, Fort Worth, Texas, USA.

Purpose Of Review: Patent ductus arteriosus (PDA) remains the most common cardiovascular condition afflicting neonates. Despite 5 decades of scientific inquiry pediatric cardiologists and neonatologists still cannot answer the simple question of which PDAs should be treated.

Recent Findings: Although the volume of the shunt is difficult to calculate, echocardiography, biochemical markers, and clinical exam can provide clues to the magnitude and physiologic consequences of the shunt. Read More

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http://Insights.ovid.com/crossref?an=00001573-900000000-9914
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http://dx.doi.org/10.1097/HCO.0000000000000580DOI Listing
January 2019
15 Reads

Advances in medical therapy for pulmonary arterial hypertension.

Curr Opin Cardiol 2019 Jan;34(1):98-103

Cardiopulmonary Department, Ignacio Chavez National Heart Institute, Mexico City Mexico.

Purpose Of Review: The purpose of this review is to demonstrate advances in the medical treatment of pulmonary arterial hypertension (PAH). Reviewed will be the evidence that favors the use of risk assessment in the treatment of PAH. Optimization of combination therapy depending on the risk or worsening will be reviewed. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000583DOI Listing
January 2019
23 Reads

A personalized approach to long QT syndrome.

Curr Opin Cardiol 2019 Jan;34(1):46-56

Department of Pediatrics, Pediatric Cardiology, University of Utah, Primary Children's Hospital, Salt Lake City, Utah, USA.

Purpose Of Review: Our purpose is to provide an update on the new clinical and genetic aspects of long QT syndrome (LQTS). LQTS is the most common channelopathy and a cause of syncope and sudden death in the young. Although there are 17 types of LQTS, most patients have types 1 or 2 which are due to mutations in KCNQ1 and KCNH2 (encoding for the cardiac potassium channels), and type 3 which is due to a mutation in SCN5A (encoding for the sodium channel). Read More

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http://dx.doi.org/10.1097/HCO.0000000000000587DOI Listing
January 2019
19 Reads

Value of high-density mapping in the electrophysiology laboratory.

Curr Opin Cardiol 2019 Jan;34(1):6-15

Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Purpose Of Review: This article uses three commonly encountered clinical scenarios to highlight the value of high-density mapping in the electrophysiology laboratory for the identification of the circuits and substrates during catheter ablation of complex arrhythmias.

Recent Findings: High-density mapping gathered with a multielectrode catheter, with its smaller individual electrode size and closer interelectrode spacing, helps during ablation procedures in a number of ways. When high-density mapping is performed during tachycardia, the characterization of macro-reentrant circuits is better. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000576DOI Listing
January 2019
15 Reads
2.700 Impact Factor

New-onset atrial fibrillation after PCI and CABG for left main disease: insights from the EXCEL trial and additional studies.

Curr Opin Cardiol 2018 Nov;33(6):660-664

Purpose Of Review: To provide an up-to-date review of recent trials examining the incidence and prognostic impact of new-onset atrial fibrillation (NOAF) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) and the impact of postprocedural NOAF compared to nonsurgical atrial fibrillation.

Recent Findings: A recent analysis from the Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) trial demonstrated that NOAF is much more frequent following surgical compared with percutaneous revascularization for LMCAD, and is strongly associated with an increased 3-year risk of mortality and stroke. In a recent Danish registry-based, propensity score-matched analysis, postsurgical NOAF conferred a lower risk of adverse outcomes compared with nonsurgical nonvalvular atrial fibrillation. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000557DOI Listing
November 2018
1 Read

Coronary artery calcification: recent developments in our understanding of its pathologic and clinical significance.

Curr Opin Cardiol 2018 Nov;33(6):645-652

CVPath institute, Gaithersburg.

Purpose Of Review: Prior investigations have shown the close association between coronary artery calcification (CAC) and total atherosclerotic plaque burden as well as the risk of cardiovascular and all-cause mortality. However, recent pathologic and imaging-based studies suggested that massive dense calcifications are usually associated with stable plaque; whereas, micro calcifications, especially in the thin fibrous cap, are related to vulnerable characteristics. Further, the molecular mechanisms for initiation/progression of vascular calcification are highly complex and still need to be elucidated. Read More

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http://Insights.ovid.com/crossref?an=00001573-900000000-9916
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http://dx.doi.org/10.1097/HCO.0000000000000558DOI Listing
November 2018
19 Reads