1,131 results match your criteria Current Vascular Pharmacology[Journal]


Vascular dysfunction and insulin resistance in aging.

Curr Vasc Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw. Poland.

Insulin was discovered in 1922 by Banting and Best. Since that time, extensive research on the mechanisms of insulin activity and action has continued. Currently, it is known that the role of insulin is much greater than simply regulating carbohydrate metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161117666181129113611DOI Listing
November 2018

Endothelial and Cardiac Dysfunction in Inflammatory Bowel Diseases: Does Treatment Modify the Inflammatory Load on Arterial and Cardiac Structure and Function?

Curr Vasc Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

2nd Academic Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

Inflammatory bowel diseases (IBD), largely represented by Crohn's disease (CD) and ulcerative colitis (UC), alter gastrointestinal physiology and mucosal immunity through a complex inflammatory process. These diseases can lead to significant arterial endothelial dysfunction. There is also evidence linking IBD with a modification of cardiac structure and function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161117666181129095941DOI Listing
November 2018
2 Reads

The Effect of Drugs and Genetic Factors on the Development and Progression of the Atherosclerotic Process.

Curr Vasc Pharmacol 2019 ;17(1):3-5

Institute of Histology and Embryology Faculty of Medicine University of Ljubljana, Ljubljana, Slovenia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/157016111701181101092855DOI Listing
January 2019

Preface.

Authors:
D P Mikhailidis

Curr Vasc Pharmacol 2019 ;17(1)

Department of Clinical Biochemistry Royal Free Hospital Campus University College London Medical School London NW3 2QG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/157016111701181101091726DOI Listing
January 2019

Insulin therapy in pregnancy hypertensive diseases and its effect on the offspring and mother later in life.

Curr Vasc Pharmacol 2018 Nov 14. Epub 2018 Nov 14.

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla. Spain.

Pregnancy hypertensive disorders such as preeclampsia (PE) are strongly correlated with insulin resistance, a condition in which the metabolic handling of D-glucose is deficient. In addition, the impact of preeclampsia is enhanced by other insulin resistant disorders, including polycystic ovary syndrome and obesity. For this reason, there is a clear association among maternal insulin resistance, polycystic ovary syndrome, obesity and the development of PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161117666181114125109DOI Listing
November 2018
2 Reads

The role of Angiotensin-(1-7)/Mas axis and Angiotensin Type 2 Receptors in the Central Nervous System in Cardiovascular Disease and therapeutics: A riddle to be solved.

Curr Vasc Pharmacol 2018 Nov 5. Epub 2018 Nov 5.

First Department of Cardiology, 'Hippokration' Hospital of Athens, University of Athens, Medical School . China.

In recent years, the Angiotensin-(1-7)/Mas receptor [Ang-(1-7)/Mas] sub-branch of the Renin-Angiotensin System (RAS) in the brain, as well as Angiotensin Type 2 Receptors (AT2R), have attracted scientific interest, as there is evidence that they constitute an essential pathway in cardiovascular regulation, in health and in disease. By acting centrally, the Ang-(1-7)/Mas axis - that has been termed 'the axis of good'- can exert blood pressure-lowering effects, while also favourably altering baroreflex sensitivity and noradrenergic neurotransmission. Thus, research has focused on the possible neuro- and cardioprotective effects of this pathway in the setting of cardiovascular disease, ultimately aiming to evaluate the potential for development of novel therapeutic strategies based on its modulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161117666181105154843DOI Listing
November 2018
4 Reads

Clopidogrel Hypersensitivity: Pathogenesis, Presentation, and Diagnosis.

Curr Vasc Pharmacol 2018 Oct 31. Epub 2018 Oct 31.

Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia, PA. United States.

This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666181031143628DOI Listing
October 2018
1 Read

Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man.

Curr Vasc Pharmacol 2018 Oct 30. Epub 2018 Oct 30.

European Center for Angioscience (ECAS) Dept. of Vascular Biology & Tumor Angiogenesis Medical Faculty Mannheim, Heidelberg University Ludolf-Krehl-Str. 13-17, 68167 Mannheim. Germany.

Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of a negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new evidence on the induction of vascular pathologies in zebrafish through metabolic disease is available. Here, we raise the question, if zebrafish can be utilized to study the initial impairments of vascular complications in metabolic disorders. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/166777/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666181031101413DOI Listing
October 2018
6 Reads

Clopidogrel Desensitization: Background and Recommendations for Use of a Rapid (4 Hour) Protocol.

Curr Vasc Pharmacol 2018 Oct 30. Epub 2018 Oct 30.

Department of Asthma, Allergy and Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, California 92130. United States.

The purpose of this section is to educate the reader on how to successfully manage patients with a hypersensitivity reaction to clopidogrel using desensitization protocol based on various published protocols. Additionally we will define drug desensitization, describe the possible mechanism of how desensitization may function, alternative medication. The indications/contraindications for desensitization will be reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666181031101930DOI Listing
October 2018
11 Reads

Diabetes and Mortality in Acute Coronary Syndrome: Findings from the Gulf COAST registry.

Curr Vasc Pharmacol 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Al-Adan, Ministry of Health. Kuwait.

Background: The prevalence of traditional risk factors such as diabetes mellitus (DM) and obesity are increasing in patients with acute coronary syndrome (ACS). Furthermore, outcomes after ACS are worse in patients with DM. The high prevalence of DM and an early age at onset of ACS have been described in prior publications from the Gulf Coast Database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666181024094337DOI Listing
October 2018
8 Reads
2.970 Impact Factor

The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results.

Curr Vasc Pharmacol 2018 Oct 5. Epub 2018 Oct 5.

Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh. Saudi Arabia.

Aim: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region.

Method: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165990/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666181005125459DOI Listing
October 2018
3 Reads

Cushing's Syndrome should be Cited as a Disease with High Cardiovascular Risk in Relevant Guidelines.

Curr Vasc Pharmacol 2018 Oct 5. Epub 2018 Oct 5.

Health Centre Jagodina, Emergency Medical Service, Jagodina. Serbia.

The intention of the paper is to give rationale and to suggest enlisting Cushing's syndrome (CS) amongst high cardiovascular (CV) risk conditions. A considerable amount of data refers to several-fold amplified mortality in CS. The causes are based on high occurrence of many CV risk factors in persons with CS (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666181005122339DOI Listing
October 2018
1 Read
2.970 Impact Factor

Cardiovascular risk in perimenopausal women.

Curr Vasc Pharmacol 2018 Oct 2. Epub 2018 Oct 2.

Chelsea and Westminster Hospital, London. United Kingdom.

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165863/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666181002145340DOI Listing
October 2018
1 Read

Extracellular vesicles and insulin resistance: a potential interaction in vascular dysfunction.

Curr Vasc Pharmacol 2018 Oct 1. Epub 2018 Oct 1.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetricsm, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024. Chile.

Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165819/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666181002095745DOI Listing
October 2018
1 Read

Smoking and Endothelial Dysfunction.

Curr Vasc Pharmacol 2018 Sep 13. Epub 2018 Sep 13.

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia. Canada.

Cigarette smoking is one the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165412/article
Publisher Site
http://dx.doi.org/10.2174/1573403X14666180913120015DOI Listing
September 2018
6 Reads

Editorial: Lipoprotein Subfractions in Patients with Acute Coronary Syndromes: Should we Reach Beyond LDL-C?

Authors:
Peter P Toth

Curr Vasc Pharmacol 2018 Jun 13. Epub 2018 Jun 13.

CGH Medical Center Sterling, Illinois Johns Hopkins University School of Medicine Baltimore, Maryland. United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116999180613120902DOI Listing
June 2018
1 Read

Involvement of intracellular pH in vascular insulin resistance.

Curr Vasc Pharmacol 2018 Sep 10. Epub 2018 Sep 10.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024. Chile.

The maintenance of the pH homeostasis is maintained by several mechanisms including the efflux of protons (H+) via membrane transporters expressed in almost all mammalian cells. Along these membrane transporters the sodium/H+ exchangers (NHEs), mainly NHE isoform 1 (NHE1), plays a key role in this phenomenon. NHE1 is under modulation by several environmental conditions (v. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180911104012DOI Listing
September 2018

Non-hormonal replacement therapy regimens: do they have an effect on cardiovascular risk?

Curr Vasc Pharmacol 2018 Sep 10. Epub 2018 Sep 10.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki. Greece.

Introduction: Menopause is associated with adverse effects on quality of life of peri-menopausal and post-menopausal women. It also has an impact on the development of cardiovascular disease (CVD). Hormonal treatments are the most effective medications for menopausal symptoms relief. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180911104942DOI Listing
September 2018
1 Read

Metabolic syndrome during menopause.

Curr Vasc Pharmacol 2018 Sep 3. Epub 2018 Sep 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Hacettepe University, 06100, Sihhiye, Ankara. Turkey.

The metabolic syndrome (MetS) comprises individual components including central obesity, insulin resistance, dyslipidaemia and hypertension and it is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The menopause per se increases the incidence of MetS in aging women. The effect(s) of menopause on individual components of MetS include: i) increasing central obesity with changes in the fat tissue distribution, ii) potential increase in insulin resistance, iii) changes in serum lipid concentrations, which seem to be associated with increasing weight rather than menopause itself, and, iv) an association between menopause and hypertension, although available data are inconclusive. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165090/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666180904094149DOI Listing
September 2018
6 Reads

Resistance to Diuretics in Heart Failure: Any Role for Empagliflozin?

Curr Vasc Pharmacol 2018 Aug 31. Epub 2018 Aug 31.

Department of Cardiology, Larissa University Hospital, Larissa. Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180831124717DOI Listing

Cardiovascular autonomic neuropathy and distal symmetric sensorimotor polyneuropathy: these two diabetic microvascular complications do not invariably co-exist.

Curr Vasc Pharmacol 2018 Aug 29. Epub 2018 Aug 29.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis. Greece.

Background: Cardiovascular autonomic neuropathy (CAN) and distal symmetrical sensorimotor polyneuropathy (DSPN) are serious microvascular complications of diabetes mellitus (DM). Their simultaneous development remains disputable. The aim of the present study was to examine the correlation between CAN and the presence/severity of DSPN in DM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180829120101DOI Listing
August 2018
2 Reads

Diabetes, Incretin therapy and thoracic aortic aneurysm-what does the evidence show?

Curr Vasc Pharmacol 2018 Aug 28. Epub 2018 Aug 28.

Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm. Sweden.

Epidemiological evidence supports reduced prevalence of thoracic aortic aneurysm (TAA) in diabetes. The mechanisms underlying this negative association are unknown. Some studies support that hyperglycemia has effects on the extracellular matrix, resulting in collagen cross-links and altered proteolytic activity, which ultimately counteracts aneurysm formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180828155622DOI Listing
August 2018
7 Reads

Cardiovascular risk in postmenopausal women with polycystic ovary syndrome.

Curr Vasc Pharmacol 2018 Aug 28. Epub 2018 Aug 28.

Menopause Clinic, 2nd Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women of reproductive age. The hormonal alterations of PCOS have been linked with a higher risk of metabolic disturbances in young, reproductively active women. However, it remains to be clarified whether the presence of PCOS increases the risk of cardiovascular disease (CVD) later in life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180828154006DOI Listing
August 2018
8 Reads

Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus.

Curr Vasc Pharmacol 2018 Aug 19. Epub 2018 Aug 19.

Biology Systems Department, Physiology, Alcala University, Alcala de Henares, Madrid. Spain.

Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of cardiovascular disease (CVD) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVD is the production of altered extracellular vesicles (EVs) by senescent endothelial cells among them, microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180820115726DOI Listing

Managing Clopidogrel Hypersensitivity without Interrupting Therapy: The Toronto Approach.

Authors:
Asim N Cheema

Curr Vasc Pharmacol 2018 Aug 19. Epub 2018 Aug 19.

Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, Ontario. Canada.

Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous manifestations in most patients to angioedema in some and a systemic immune response in rare cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389200219666180820114435DOI Listing
August 2018
1 Read

The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.

Curr Vasc Pharmacol 2018 Aug 17. Epub 2018 Aug 17.

The Section of Cardiology, Department of Medicine, The University of Chicago, Chicago. United States.

Statins, 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors, have been used for decades for the prevention of coronary artery disease and stroke. They act primarily by lowering serum cholesterol through the inhibition of cholesterol synthesis in the liver, which results in the upregulation of low-density lipoprotein receptors in the liver. This results in the removal of low-density lipoprotein-cholesterol. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/164752/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666180817155058DOI Listing
August 2018
10 Reads

Clopidogrel Hypersensitivity: Overview of the Problem.

Curr Vasc Pharmacol 2018 Aug 20. Epub 2018 Aug 20.

Department of Medicine (Cardiology), Thomas Jefferson University Hospital; Philadelphia, Pennsylvania. United States.

Clopidogrel is one of the most commonly prescribed drugs worldwide. It plays an essential therapeutic role in a variety of vascular conditions including acute coronary syndromes, ischemic heart disease treated with coronary stents, stroke, and peripheral vascular disease. Hypersensitivity reactions to clopidogrel are not uncommon and lead to its discontinuation in 1-2% of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180820123041DOI Listing
August 2018
7 Reads

Regional Distribution of Nitric Oxide Synthase in Human Anorectal Tissue: A Pilot Study on the Potential Role for Nitric Oxide in Haemorrhoids.

Curr Vasc Pharmacol 2018 Jul 29. Epub 2018 Jul 29.

Surgical and Interventional Sciences, Royal Free and University College Medical School, London. United Kingdom.

Objective: To study the distribution of nitric oxide synthase (NOS) isoforms and protein levels in human haemorrhoids and rectal tissue Methods: Protein expression of NOS1, NOS2 and NOS3 were compared between haemorrhoids (n=14) and normal rectal submucosa (n=6) using Western blot analysis. Localisation of all NOS isoforms to specific structures was determined by immunohistochemistry.

Results: Western blot analysis showed median (interquartile range) protein levels of all NOS isoforms were 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180730101532DOI Listing
July 2018
1 Read

Use of alternative antiplatelet agents for clopidogrel hypersensitivity.

Authors:
A Ather C J Beavers

Curr Vasc Pharmacol 2018 Jul 29. Epub 2018 Jul 29.

Department of Pharmacy Services, UK Healthcare, University of Kentucky College of Pharmacy, 800 Rose St, Lexington, KY 40536. United States.

Clopidogrel is a widely used agent for secondary prevention of vascular events and is a cornerstone of dual antiplatelet therapy in patients with acute coronary syndrome (ACS) post coronary stent implantation. Hypersensitivity reactions to clopidogrel are well documented and may range from localized to systemic in presentation. This can lead to discontinuation of therapy, thus increasing the risk of vascular events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180730100806DOI Listing

Treatment of Clopidogrel Hypersensitivity: The Jefferson Approach.

Curr Vasc Pharmacol 2018 Jul 29. Epub 2018 Jul 29.

Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA. United States.

Despite the advent of newer antiplatelet therapies, clopidogrel remains the mainstay of treatment for patients with cardiovascular disease, especially those who undergo coronary stent implantation. Hypersensitivity reactions to clopidogrel that develop soon after stenting present a significant clinical challenge. The widespread use of clopidogrel in the management of patients with coronary artery disease necessitates awareness of treatment options in the setting of an allergic reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180730100346DOI Listing
July 2018
1 Read

Pleotropic Effects of Statins: untapped potential for statin pharmacotherapy.

Curr Vasc Pharmacol 2018 Jul 23. Epub 2018 Jul 23.

The Ohio State University, College of Medicine, Department of Biological Chemistry and Pharmacology, Columbus, Ohio. United States.

Background: Statins are effective for primary and secondary prevention of atherosclerotic cardiovascular disease. They also have systemic anti-inflammatory and immunomodulating properties suggesting potential utility for improving clinical outcomes for a wide range of diseases. The literature provides data suggesting benefit in patients with comorbidities associated with contrast-induced nephropathy (CIN), chronic obstructive pulmonary disease (COPD), pneumonia, head injury, neurological disease (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180723120608DOI Listing
July 2018
8 Reads

Statins: They are Really All the Same?

Curr Vasc Pharmacol 2018 Jul 13. Epub 2018 Jul 13.

Cardiovascular Diseases Section "Monsignor Dimiccoli" Hospital Barletta. Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180713120217DOI Listing

Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives.

Curr Vasc Pharmacol 2018 Jul 11. Epub 2018 Jul 11.

First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki. Greece.

There is increasing evidence that menopause is associated with the progression and severity of non-alcoholic fatty liver disease (NAFLD). Estrogen deficiency worsens non-alcoholic steatohepatitis (NASH) in mice models with fatty liver. The prevalence of NAFLD seems to be higher in postmenopausal compared with premenopausal women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180711121949DOI Listing
July 2018
25 Reads

Statins: pharmacokinetics, pharmacodynamics, and cost-effectiveness analysis.

Curr Vasc Pharmacol 2018 Jul 6. Epub 2018 Jul 6.

Cardiovascular Diseases Section, "Monsignor Dimiccoli" Hospital, Barletta. Italy.

Cardiovascular diseases secondary to atherosclerosis are the primary causes of early death and disability worldwide and dyslipidaemia represents one of the most important modifiable risk factors. Among lipid abnormalities that define it, low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy, since multiple randomized controlled trials have shown the positive impact of its reduction on atherosclerosis development. For their ability to lower LDL-C levels, statins are the most studied drugs in cardiovascular disease prevention, of proven utility in slowing the progression or even determining regression of atherosclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180706144824DOI Listing
July 2018
10 Reads

Menopausal hormone therapy and cardiovascular risk. Where are we now?

Curr Vasc Pharmacol 2018 Jul 8. Epub 2018 Jul 8.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki. Greece.

Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause <45 years) and premature ovarian insufficiency (POI, defined as age at menopause <40 years) are associated with 1.5-2-fold increase in CVD risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180709095348DOI Listing
July 2018
15 Reads

Galectin-3 and arterial stiffness in patients with heart failure: a pilot study.

Curr Vasc Pharmacol 2018 Jul 2. Epub 2018 Jul 2.

1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens. Greece.

Background: Cardiac performance depends on optimum ventriculoarterial coupling which is impaired in patients with heart failure (HF). Galectin-3 is a mediator of myocardial fibrosis and remodeling, and is associated with clinical status in patients with chronic HF. We examined the association of arterial stiffness with galectin-3 levels in patients with HF of ischemic etiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180703094919DOI Listing
July 2018
2 Reads

Statins and elderly: from clinical trials to daily practice.

Curr Vasc Pharmacol 2018 Jun 28. Epub 2018 Jun 28.

Department of Cardiology AOU Maggiore della Carita, Universita del Piemonte Orientale, Novara. Italy.

Elderly patients represent a rising social problem, due to the exponential growth of persons in these age groups and their atherothrombotic burden. The management of this population still raises several challenges, requiring a balance between elevated cardiovascular risk, clinical complexity, frailty and co-morbidities. Statins represent a main pillar in cardiovascular prevention, lowering serum cholesterol and reducing mortality and ischemic events, especially in high-risk patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180628145723DOI Listing
June 2018
2 Reads

Diabetes in menopause: risks and management.

Curr Vasc Pharmacol 2018 06 25. Epub 2018 Jun 25.

Division of Endocrinology and Diabetes, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

The aim of this review is to present, critically appraise and qualitatively synthesize current evidence on the risk of type 2 diabetes mellitus (T2DM) development during menopause, the management of climacteric symptoms in women with T2DM and the management of T2DM in postmenopausal women. Menopause represents the end of reproductive life in women, as a result of ovarian aging. It is characterized by substantial decrease in the endogenous oestrogen concentrations and it is accompanied by alterations in body weight, adipose tissue distribution and energy expenditure, as well as insulin secretion, insulin sensitivity and activity that can predispose to the development of T2DM, independently of, and additively to, aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180625124405DOI Listing
June 2018
16 Reads

Gender-specific, Lifestyle-related Factors and 10-year Cardiovascular Disease Risk; the ATTICA and GREECS Cohort Studies.

Curr Vasc Pharmacol 2018 06 8. Epub 2018 Jun 8.

. 0.

Background: Lifestyle remains a huge driving force of cardiovascular diseases (CVD) onset/progression. Lifestyle-patterns are highly dependent on gender-related attitudes.

Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), physical activity (PA), smoking) on 10-year first and recurrent CVD events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180608121720DOI Listing
June 2018
26 Reads
2.970 Impact Factor

Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; Α Randomised Clinical Trial.

Curr Vasc Pharmacol 2018 Jun 4. Epub 2018 Jun 4.

Atherothrombosis Research Centre, University of Ioannina, Ioannina. Greece.

Background: Triflusal has demonstrated an efficacy similar to aspirin in the prevention of vascular events in patients with acute myocardial infarction (ΜΙ) and ischaemic stroke but with less bleeding events.

Objective: We performed a randomised, multicentre, phase 4 clinical trial to compare the clinical efficacy and safety of triflusal versus aspirin, administered for 12 months in patients eligible to receive a cyclooxygenase-1 (COX-1) inhibitor.

Method: Patients with stable coronary artery disease or with a history of non-cardioembolic ischaemic stroke were randomly assigned to receive either triflusal 300 mg twice or 600 mg once daily or aspirin 100 mg once daily for 12 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180605090520DOI Listing
June 2018
50 Reads
2.970 Impact Factor

Aspirin hypersensitivity in patients undergoing percutaneous coronary intervention. What should we be doing?

Curr Vasc Pharmacol 2018 Jun 3. Epub 2018 Jun 3.

2nd Department of Cardiology, Attikon University Hospital, National and Capodistrian University of Athens Medical School, Athens. Greece.

Aspirin plays a pivotal role in the management of patients with coronary artery disease (CAD) with well recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing percutaneous coronary intervention (PCI). Dual antiplatelet therapy is mandated for patients undergoing PCI and typically consists of aspirin and a P2Y12 receptor antagonist. Aspirin hypersensitivity poses a significant clinical dilemma, as the safety and efficacy of oral antiplatelet combinations that exclude aspirin have not been validated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180604100220DOI Listing

Cholesterol subfraction analysis in patients with acute coronary syndrome.

Curr Vasc Pharmacol 2018 May 31. Epub 2018 May 31.

Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz. Poland.

Background: There is a close relationship between lipid metabolism disorders and atherosclerosis. Guidelines focus on lowering low density lipoprotein cholesterol (LDL-C) levels. However, it should be kept in mind that LDL and high density lipoprotein (HDL) consist of subfractions which can affect the progression of atherosclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180601083225DOI Listing
May 2018
1 Read

Switching dipeptidyl peptidase-4 inhibitors to tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2 improves arterial stiffness evaluated by cardio-ankle vascular index in patients with type 2 diabetes: a pilot study

Curr Vasc Pharmacol 2018 05 15. Epub 2018 May 15.

Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume. Japan.

Background: We have found that anagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4) significantly ameliorates arterial stiffness in type 2 diabetes mellitus (T2DM) patients compared with an equivalent hypoglycaemic agent, glimepiride. However, it remains unclear whether switching DPP-4 inhibitors to tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) improves arterial stiffness in T2DM patients.

Methods: Nineteen T2DM patients who had received DPP-4 inhibitors for at least 1 year were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180515154555DOI Listing
May 2018
4 Reads

Editorial: Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis: An Epidemic that will Boost the Incidence of Cardiovascular Morbidity and Mortality.

Curr Vasc Pharmacol 2018 ;16(3):206-208

Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/157016111603180326112541DOI Listing
January 2018
1 Read

Clinical presentation, Quality of care, Risk factors and Outcomes in Women with Acute ST-Elevation Myocardial Infarction (STEMI): An Observational Report from Six Middle Eastern Countries.

Curr Vasc Pharmacol 2018 03 14. Epub 2018 Mar 14.

Adult Cardiology, Hamad Medical Corporation, Doha. Qatar.

Background: Most of the available literature on ST-Elevated myocardial infarction (STEMI) in women was conducted in the developed world and data from Middle-East countries was limited.

Aim: To examine the clinical presentation, patient management, quality of care, risk factors and in-hospital outcomes of women with acute STEMI compared with men using data from a large STEMI registry from the Middle East.

Methods: Data were derived from the third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps), a prospective, multinational study of adults with acute STEMI from 36 hospitals in 6 Middle-Eastern countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180315104820DOI Listing
March 2018
5 Reads
2.970 Impact Factor

Platelet-derived exosomes affect the proliferation and migration of human umbilical vein endothelial cells via miR-126.

Curr Vasc Pharmacol 2018 Mar 13. Epub 2018 Mar 13.

Department of Cardiology, Beijing Anzhen Hospital; Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, No. 2 Anzhen Road, Chaoyang District, Beijing. China.

Background: Intraplaque angiogenesis, the process of generating new blood vessels mediated by endothelial cells, contributes to plaque growth, intraplaque hemorrhage, and thromboembolic events. Platelet-derived exosomes (PLT-EXOs) affect angiogenesis in multiple ways. The ability of miR-126, one of the best-characterized miRNAs that regulates angiogenesis, carried by PLT-EXOs to influence angiogenesis via the regulation of the proliferation and migration of endothelial cells is unknown. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/160444/article
Publisher Site
http://dx.doi.org/10.2174/1570161116666180313142139DOI Listing
March 2018
10 Reads

Effects of Intensive Blood Pressure Control in Patients with Evident Cardiovascular Disease: An investigation using the SPRINT study data.

Curr Vasc Pharmacol 2018 Mar 5. Epub 2018 Mar 5.

Hypertension and Cardiometabolic Unit, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

Background: Recent data advocate adoption of a more intensive treatment strategy for management of blood pressure (BP).

Objective: We investigated whether the overall effects of the Systolic Blood Pressure Intervention Trial (SPRINT) are applicable to cardiovascular disease (CVD) patients.

Method: In a post-hoc analysis we analyzed data from SPRINT that randomly assigned 9361 individuals to a systolic BP (SBP) target of <120 mmHg (intensive treatment) or <140 mmHg (standard treatment). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180305160116DOI Listing
March 2018
4 Reads

Effects of Estrogen in Gender-dependent Fetal Programming of Adult Cardiovascular Dysfunction.

Curr Vasc Pharmacol 2018 Mar 1. Epub 2018 Mar 1.

Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California. United States.

Background: Epidemiological studies and experimental studies have demonstrated that intrauterine adverse environment increases the risk of cardiovascular disease (CVD) in adulthood. However, whether an individual develops a cardiovascular dysfunctional phenotype may depend on genetic background, age, and sex.

Methods: In this review, we summarize some of the recent experimental animal studies in the developmental programming of adult CVD with an emphasis on sex differences and the potential role of estrogen in mediating sexual dimorphism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180301142453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193848PMC
March 2018
3 Reads

Involvement of PI3K, Akt, and RhoA in oestradiol regulation of cardiac iNOS expression.

Curr Vasc Pharmacol 2018 Feb 12. Epub 2018 Feb 12.

Institute of Nuclear Sciences "Vinca", Department of Radiobiology and Molecular Genetics, University of Belgrade, Belgrade. Serbia.

Background: Oestradiol is an important regulatory factor with several positive effects on the cardiovascular (CV) system. We evaluated the molecular mechanism of the in vivo effects of oestradiol on the regulation of cardiac inducible nitric oxide (NO) synthase (iNOS) expression and activity.

Methods: Male Wistar rats were treated with oestradiol (40 mg/kg, intraperitoneally) and after 24 h the animals were sacrificed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180212142414DOI Listing
February 2018
2 Reads

The significance of pain in chronic venous disease and its medical treatment.

Curr Vasc Pharmacol 2018 Feb 8. Epub 2018 Feb 8.

Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Sciences Vinca, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade. Serbia.

Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1570161116666180209111826DOI Listing
February 2018
3 Reads