1,143 results match your criteria Current Vascular Pharmacology[Journal]


Hypertriglyceridemia: An Infrequent, Difficult-to-Predict, Severe Metabolic and Vascular Problem Associated with Estrogen Administration.

Authors:
Thomas F Whayne

Curr Vasc Pharmacol 2019 Mar 5. Epub 2019 Mar 5.

Gill Heart and Vascular Institute University of Kentucky Lexington, Kentucky. United States.

Supplementary estrogen plays important roles for female patients as convenient birth control, relief of postmenopausal symptoms, and in management of other selected problems. However, as is the case for essentially all medications, there are side effects. Short of a major pulmonary embolus, the most severe side effect of estrogen would appear to be sporadic, rare, and severe hypertriglyceridemia associated with acute pancreatitis. Read More

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http://dx.doi.org/10.2174/1570161117666190306102322DOI Listing
March 2019
1 Read

Premature Ovarian Insufficiency and Long-Term Health Consequences.

Curr Vasc Pharmacol 2019 Jan 21. Epub 2019 Jan 21.

National Heart & Lung Institute, Imperial College London, Royal Brompton Hospital, London. United Kingdom.

Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function before the age of 40 years. The trio of amenorrhea, elevated gonadotropins and oestrogen deficiency is associated with long-term health consequences including increased cardiovascular disease (CVD), decreased bone mineral density (BMD), significantly reduced fertility, psychological distress, vulvovaginal atrophy, neurological effects and overall reduced life expectancy. There are deficits in our understanding of this condition and subsequently the long-term health consequences. Read More

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http://dx.doi.org/10.2174/1570161117666190122101611DOI Listing
January 2019
1 Read

Menopause and its Cardiometabolic Consequences: Current Perspectives.

Curr Vasc Pharmacol 2019 Feb 28. Epub 2019 Feb 28.

Sarantaporou 10, 54640 Thessaloniki. Greece.

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http://dx.doi.org/10.2174/1570161117999190228123237DOI Listing
February 2019

The bleeding risk in antithrombotic therapies: a narrative review.

Curr Vasc Pharmacol 2019 Feb 11. Epub 2019 Feb 11.

Division of Angiology, Heart and Vessel Department, Lausanne University Hospital, Lausanne. Switzerland.

Bleeding represents the most important complication of antithrombotic treatment, including anticoagulant and antiplatelet therapies. A number of scores were proposed to evaluate the risk of bleeding both for anticoagulant and antiplatelet treatment. In the last decade, 5 bleeding risk scores were published for use in atrial fibrillation patients, and 3 scores for patients receiving anticoagulants for venous thromboembolism therapy or prophylaxis. Read More

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http://dx.doi.org/10.2174/1570161117666190212112743DOI Listing
February 2019
1 Read

Antithrombotic therapy for peripheral revascularisation.

Curr Vasc Pharmacol 2019 Feb 6. Epub 2019 Feb 6.

Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa. Italy.

Lower extremity artery disease (LEAD) represents a major public health burden, affecting hundreds of millions people worldwide. Although risk-factor modification, exercise training and medical treatment are the mainstay of the management of LEAD, endovascular or surgical revascularisation is recommended when there is the risk of limb amputation and when drug-resistant claudication severely affects patient lifestyle. Over recent years, the number of peripheral vascular interventions (PVI) has soared worldwide, driven by the improvements in endovascular techniques and devices. Read More

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http://dx.doi.org/10.2174/1570161117666190206234606DOI Listing
February 2019

Antithrombotic Therapy in Lower Extremity Artery Disease.

Curr Vasc Pharmacol 2019 Feb 6. Epub 2019 Feb 6.

Department of Cardiology, Dupuytren University Hospital Centre, Limoges. France.

Lower extremity artery disease (LEAD) is a marker of a more advanced atherosclerotic process often affecting multiple vascular beds beyond the lower limbs, with a consequent increased risk for all-cause and cardiovascular mortality. Antithrombotic therapy is the cornerstone of management of these patients to prevent ischaemic cardiovascular and limb events and death. In patients with symptomatic LEAD, the efficacy of aspirin has been established long ago for the prevention of cardiovascular events. Read More

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http://dx.doi.org/10.2174/1570161117666190206230516DOI Listing
February 2019
2.966 Impact Factor

Pathophysiology of Thrombosis in Peripheral Artery Disease.

Curr Vasc Pharmacol 2019 Feb 6. Epub 2019 Feb 6.

Institute of Pharmacology, Catholic University School of Medicine. Italy.

Under physiological conditions, peripheral arteries release endogenous vascular-protective and anti-thrombotic agents. Endothelial cells actively synthesize vasoactive mediators, which regulate vascular tone and platelet reactivity thus preventing thrombosis. Atherosclerosis disrupts this homeostasis and favours thrombosis by triggering pro-thrombotic responses in the vessels, platelet activation, aggregation as well as vasoconstriction, phenomena that ultimately lead to symptomatic lumen restriction or complete occlusion In the present review, we will discuss the homeostatic role of arterial vessels in releasing vascular-protective agents, such as nitric oxide and prostacyclin, the role of pro- and anti-thrombotic vascular receptors as well as the contribution of circulating platelets and coagulation factors in triggering the pro-thrombotic response(s). Read More

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http://dx.doi.org/10.2174/1570161117666190206234046DOI Listing
February 2019
3 Reads

Tyrosine Kinase Inhibitor-Induced Hypertension: Role of Hypertension as a Biomarker in Cancer Treatment.

Curr Vasc Pharmacol 2019 Jan 30. Epub 2019 Jan 30.

Diabetes and Hormone Diseases - Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Palle Juul-Jensens Boulevard 165, 8200 Aarhus N. Denmark.

Cancer treatment is an area of continuous improvement. Therapy is becoming more targeted and the use of anti-angiogenic agents in multiple cancers, specifically tyrosine kinase inhibitors (TKIs), has demonstrated prolonged survival outcomes compared with previous drugs. Therefore, they have become a well-established part of treatment. Read More

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http://dx.doi.org/10.2174/1570161117666190130165810DOI Listing
January 2019

Effects of lipid lowering drugs on arterial stiffness. One more way to reduce cardiovascular risk?

Curr Vasc Pharmacol 2019 Jan 20. Epub 2019 Jan 20.

Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Arterial stiffness (AS) is considered an independent predictor of cardiovascular disease (CVD) events. Among lipid lowering drugs, statins have a beneficial effect on AS, independent of their hypolipidaemic effect. Based on 3 meta-analyses and other studies, this effect is compound- and dose-related. Read More

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http://dx.doi.org/10.2174/1570161117666190121102323DOI Listing
January 2019
1 Read

Effect of Early Normotension with Olmesartan on Rho-kinase Activity in Hypertensive Patients.

Curr Vasc Pharmacol 2019 Jan 20. Epub 2019 Jan 20.

Pontificia Universidad Católica de Chile, School of Medicine, Division of Cardiovascular Diseases, Santiago. Chile.

Background: Angiotensin II is a potent activator of the Rho-kinase (ROCK) pathway, through which it exerts some of its adverse vasoconstrictor effects. Clinical evidence on the effects of blocking the angiotensin II receptor 1 on ROCK activity in hypertensive patients is scarce.

Objective: To demonstrate that ROCK activity in peripheral blood mononuclear cells (PBMC) in patients with essential hypertension is reduced earlier than previously observed, along with blood pressure (BP) lowering on treatment with olmesartan. Read More

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http://dx.doi.org/10.2174/1570161117666190121103116DOI Listing
January 2019
2 Reads

Editorial: Familial Hypercholesterolaemia Registry in the MENA Region

Curr Vasc Pharmacol 2019 Jan 16. Epub 2019 Jan 16.

Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Australia

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January 2019
6 Reads

Long-Term Outcome of Acute Coronary Syndromes in Patients on Chronic Oral Anticoagulants: Data from the EPICOR Study.

Curr Vasc Pharmacol 2018 Dec 27. Epub 2018 Dec 27.

Centro Nacional de Investigaciones Cardiovasculares, Madrid. Spain.

Objective: To analyse characteristics, management and outcomes of patients with acute coronary syndromes (ACS) receiving chronic oral anticoagulant (OAC) therapy enrolled in the EPICOR (long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients) prospective, international, observational study of antithrombotic management patterns in ACS survivors (NCT01171404).

Method: This post-hoc analysis evaluated the association between OAC use at baseline (OACb) and time from hospital admission to percutaneous coronary intervention (PCI) (tHA-PCI), pre-PCI thrombolysis in myocardial infarction (TIMI) 3 flow, stent type, length of hospitalisation, and clinical endpoints; death, non-fatal MI, and non-fatal stroke, a composite of these ± bleeding, over 2 years' follow-up.

Results: Of 10,568 ACS patients, 345 (3. Read More

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http://dx.doi.org/10.2174/1570161117666181227122355DOI Listing
December 2018
1 Read

Vascular dysfunction and insulin resistance in aging.

Curr Vasc Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw. Poland.

Insulin was discovered in 1922 by Banting and Best. Since that time, extensive research on the mechanisms of insulin activity and action has continued. Currently, it is known that the role of insulin is much greater than simply regulating carbohydrate metabolism. Read More

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http://dx.doi.org/10.2174/1570161117666181129113611DOI Listing
November 2018
1 Read

Endothelial and Cardiac Dysfunction in Inflammatory Bowel Diseases: Does Treatment Modify the Inflammatory Load on Arterial and Cardiac Structure and Function?

Curr Vasc Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

2nd Academic Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

Inflammatory bowel diseases (IBD), largely represented by Crohn's disease (CD) and ulcerative colitis (UC), alter gastrointestinal physiology and mucosal immunity through a complex inflammatory process. These diseases can lead to significant arterial endothelial dysfunction. There is also evidence linking IBD with a modification of cardiac structure and function. Read More

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http://dx.doi.org/10.2174/1570161117666181129095941DOI Listing
November 2018
7 Reads

The Effect of Drugs and Genetic Factors on the Development and Progression of the Atherosclerotic Process.

Curr Vasc Pharmacol 2019 ;17(1):3-5

Institute of Histology and Embryology Faculty of Medicine University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.2174/157016111701181101092855DOI Listing
January 2019
1 Read

Preface.

Authors:
D P Mikhailidis

Curr Vasc Pharmacol 2019 ;17(1)

Department of Clinical Biochemistry Royal Free Hospital Campus University College London Medical School London NW3 2QG, United Kingdom.

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http://dx.doi.org/10.2174/157016111701181101091726DOI Listing
January 2019
1 Read

Insulin therapy in pregnancy hypertensive diseases and its effect on the offspring and mother later in life.

Curr Vasc Pharmacol 2018 Nov 14. Epub 2018 Nov 14.

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla. Spain.

Pregnancy hypertensive disorders such as preeclampsia (PE) are strongly correlated with insulin resistance, a condition in which the metabolic handling of D-glucose is deficient. In addition, the impact of preeclampsia is enhanced by other insulin resistant disorders, including polycystic ovary syndrome and obesity. For this reason, there is a clear association among maternal insulin resistance, polycystic ovary syndrome, obesity and the development of PE. Read More

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http://dx.doi.org/10.2174/1570161117666181114125109DOI Listing
November 2018
4 Reads

The role of Angiotensin-(1-7)/Mas axis and Angiotensin Type 2 Receptors in the Central Nervous System in Cardiovascular Disease and therapeutics: A riddle to be solved.

Curr Vasc Pharmacol 2018 Nov 5. Epub 2018 Nov 5.

First Department of Cardiology, 'Hippokration' Hospital of Athens, University of Athens, Medical School . China.

In recent years, the Angiotensin-(1-7)/Mas receptor [Ang-(1-7)/Mas] sub-branch of the Renin-Angiotensin System (RAS) in the brain, as well as Angiotensin Type 2 Receptors (AT2R), have attracted scientific interest, as there is evidence that they constitute an essential pathway in cardiovascular regulation, in health and in disease. By acting centrally, the Ang-(1-7)/Mas axis - that has been termed 'the axis of good'- can exert blood pressure-lowering effects, while also favourably altering baroreflex sensitivity and noradrenergic neurotransmission. Thus, research has focused on the possible neuro- and cardioprotective effects of this pathway in the setting of cardiovascular disease, ultimately aiming to evaluate the potential for development of novel therapeutic strategies based on its modulation. Read More

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http://dx.doi.org/10.2174/1570161117666181105154843DOI Listing
November 2018
9 Reads

Clopidogrel Hypersensitivity: Pathogenesis, Presentation and Diagnosis.

Curr Vasc Pharmacol 2019 ;17(2):110-112

Jane and Leonard Korman Respiratory Institute, Division of Pulmonary, Allergy & Critical Care Medicine, Allergy & Immunology Section, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, United States.

This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Read More

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http://dx.doi.org/10.2174/1570161116666181031143628DOI Listing
January 2019
3 Reads

Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man.

Curr Vasc Pharmacol 2018 Oct 30. Epub 2018 Oct 30.

European Center for Angioscience (ECAS) Dept. of Vascular Biology & Tumor Angiogenesis Medical Faculty Mannheim, Heidelberg University Ludolf-Krehl-Str. 13-17, 68167 Mannheim. Germany.

Endothelial dysfunction is an initial pathophysiological mechanism of vascular damage and is further recognized as an independent predictor of a negative prognosis in diabetes-induced micro- and macrovascular complications. Insight into the capability of zebrafish to model metabolic disease like obesity and type II diabetes has increased and new evidence on the induction of vascular pathologies in zebrafish through metabolic disease is available. Here, we raise the question, if zebrafish can be utilized to study the initial impairments of vascular complications in metabolic disorders. Read More

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http://www.eurekaselect.com/166777/article
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http://dx.doi.org/10.2174/1570161116666181031101413DOI Listing
October 2018
7 Reads

Clopidogrel Desensitization: Background and Recommendations for Use of a Rapid (4 Hour) Protocol.

Curr Vasc Pharmacol 2019 ;17(2):113-118

Department of Asthma, Allergy and Immunology, Scripps Clinic and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92130, United States.

The purpose of this section is to educate the reader on how to successfully manage patients with a hypersensitivity reaction to clopidogrel using desensitization protocol based on various published protocols. Additionally, we will define drug desensitization, and describe the possible mechanism of how desensitization may function as alternative medication. The indications/contraindications for desensitization will be reviewed. Read More

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http://dx.doi.org/10.2174/1570161116666181031101930DOI Listing
January 2019
12 Reads

Diabetes and Mortality in Acute Coronary Syndrome: Findings from the Gulf COAST registry.

Curr Vasc Pharmacol 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Al-Adan, Ministry of Health. Kuwait.

Background: The prevalence of traditional risk factors such as diabetes mellitus (DM) and obesity are increasing in patients with acute coronary syndrome (ACS). Furthermore, outcomes after ACS are worse in patients with DM. The high prevalence of DM and an early age at onset of ACS have been described in prior publications from the Gulf Coast Database. Read More

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http://dx.doi.org/10.2174/1570161116666181024094337DOI Listing
October 2018
30 Reads
2.970 Impact Factor

The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results.

Curr Vasc Pharmacol 2018 Oct 5. Epub 2018 Oct 5.

Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh. Saudi Arabia.

Aim: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region.

Method: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. Read More

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http://www.eurekaselect.com/165990/article
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http://dx.doi.org/10.2174/1570161116666181005125459DOI Listing
October 2018
7 Reads

Cushing's Syndrome should be Cited as a Disease with High Cardiovascular Risk in Relevant Guidelines.

Curr Vasc Pharmacol 2018 Oct 5. Epub 2018 Oct 5.

Health Centre Jagodina, Emergency Medical Service, Jagodina. Serbia.

The intention of the paper is to give rationale and to suggest enlisting Cushing's syndrome (CS) amongst high cardiovascular (CV) risk conditions. A considerable amount of data refers to several-fold amplified mortality in CS. The causes are based on high occurrence of many CV risk factors in persons with CS (e. Read More

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http://dx.doi.org/10.2174/1570161116666181005122339DOI Listing
October 2018
6 Reads
2.970 Impact Factor

Cardiovascular risk in perimenopausal women.

Curr Vasc Pharmacol 2018 Oct 2. Epub 2018 Oct 2.

Chelsea and Westminster Hospital, London. United Kingdom.

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Read More

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http://www.eurekaselect.com/165863/article
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http://dx.doi.org/10.2174/1570161116666181002145340DOI Listing
October 2018
3 Reads

Extracellular vesicles and insulin resistance: a potential interaction in vascular dysfunction.

Curr Vasc Pharmacol 2018 Oct 1. Epub 2018 Oct 1.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetricsm, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024. Chile.

Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. Read More

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http://www.eurekaselect.com/165819/article
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http://dx.doi.org/10.2174/1570161116666181002095745DOI Listing
October 2018
2 Reads

Smoking and Endothelial Dysfunction.

Curr Vasc Pharmacol 2018 Sep 13. Epub 2018 Sep 13.

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia. Canada.

Cigarette smoking is one the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. Read More

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http://www.eurekaselect.com/165412/article
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http://dx.doi.org/10.2174/1573403X14666180913120015DOI Listing
September 2018
8 Reads

Editorial: Lipoprotein Subfractions in Patients with Acute Coronary Syndromes: Should we Reach Beyond LDL-C?

Authors:
Peter P Toth

Curr Vasc Pharmacol 2018 Jun 13. Epub 2018 Jun 13.

CGH Medical Center Sterling, Illinois Johns Hopkins University School of Medicine Baltimore, Maryland. United States.

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http://dx.doi.org/10.2174/1570161116999180613120902DOI Listing
June 2018
2 Reads

Involvement of intracellular pH in vascular insulin resistance.

Curr Vasc Pharmacol 2018 Sep 10. Epub 2018 Sep 10.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024. Chile.

The maintenance of the pH homeostasis is maintained by several mechanisms including the efflux of protons (H+) via membrane transporters expressed in almost all mammalian cells. Along these membrane transporters the sodium/H+ exchangers (NHEs), mainly NHE isoform 1 (NHE1), plays a key role in this phenomenon. NHE1 is under modulation by several environmental conditions (v. Read More

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http://dx.doi.org/10.2174/1570161116666180911104012DOI Listing
September 2018
2 Reads

Non-hormonal replacement therapy regimens: do they have an effect on cardiovascular risk?

Curr Vasc Pharmacol 2018 Sep 10. Epub 2018 Sep 10.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki. Greece.

Introduction: Menopause is associated with adverse effects on quality of life of peri-menopausal and post-menopausal women. It also has an impact on the development of cardiovascular disease (CVD). Hormonal treatments are the most effective medications for menopausal symptoms relief. Read More

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http://dx.doi.org/10.2174/1570161116666180911104942DOI Listing
September 2018
3 Reads

Metabolic syndrome during menopause.

Curr Vasc Pharmacol 2018 Sep 3. Epub 2018 Sep 3.

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Hacettepe University, 06100, Sihhiye, Ankara. Turkey.

The metabolic syndrome (MetS) comprises individual components including central obesity, insulin resistance, dyslipidaemia and hypertension and it is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The menopause per se increases the incidence of MetS in aging women. The effect(s) of menopause on individual components of MetS include: i) increasing central obesity with changes in the fat tissue distribution, ii) potential increase in insulin resistance, iii) changes in serum lipid concentrations, which seem to be associated with increasing weight rather than menopause itself, and, iv) an association between menopause and hypertension, although available data are inconclusive. Read More

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http://www.eurekaselect.com/165090/article
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http://dx.doi.org/10.2174/1570161116666180904094149DOI Listing
September 2018
7 Reads

Resistance to Diuretics in Heart Failure: Any Role for Empagliflozin?

Curr Vasc Pharmacol 2018 Aug 31. Epub 2018 Aug 31.

Department of Cardiology, Larissa University Hospital, Larissa. Greece.

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http://dx.doi.org/10.2174/1570161116666180831124717DOI Listing
August 2018
1 Read

Cardiovascular autonomic neuropathy and distal symmetric sensorimotor polyneuropathy: these two diabetic microvascular complications do not invariably co-exist.

Curr Vasc Pharmacol 2018 Aug 29. Epub 2018 Aug 29.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis. Greece.

Background: Cardiovascular autonomic neuropathy (CAN) and distal symmetrical sensorimotor polyneuropathy (DSPN) are serious microvascular complications of diabetes mellitus (DM). Their simultaneous development remains disputable. The aim of the present study was to examine the correlation between CAN and the presence/severity of DSPN in DM. Read More

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http://dx.doi.org/10.2174/1570161116666180829120101DOI Listing
August 2018
4 Reads

Diabetes, Incretin therapy and thoracic aortic aneurysm-what does the evidence show?

Curr Vasc Pharmacol 2018 Aug 28. Epub 2018 Aug 28.

Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm. Sweden.

Epidemiological evidence supports reduced prevalence of thoracic aortic aneurysm (TAA) in diabetes. The mechanisms underlying this negative association are unknown. Some studies support that hyperglycemia has effects on the extracellular matrix, resulting in collagen cross-links and altered proteolytic activity, which ultimately counteracts aneurysm formation. Read More

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http://dx.doi.org/10.2174/1570161116666180828155622DOI Listing
August 2018
14 Reads

Cardiovascular risk in postmenopausal women with polycystic ovary syndrome.

Curr Vasc Pharmacol 2018 Aug 28. Epub 2018 Aug 28.

Menopause Clinic, 2nd Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women of reproductive age. The hormonal alterations of PCOS have been linked with a higher risk of metabolic disturbances in young, reproductively active women. However, it remains to be clarified whether the presence of PCOS increases the risk of cardiovascular disease (CVD) later in life. Read More

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http://dx.doi.org/10.2174/1570161116666180828154006DOI Listing
August 2018
20 Reads

Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus.

Curr Vasc Pharmacol 2018 Aug 19. Epub 2018 Aug 19.

Biology Systems Department, Physiology, Alcala University, Alcala de Henares, Madrid. Spain.

Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of cardiovascular disease (CVD) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVD is the production of altered extracellular vesicles (EVs) by senescent endothelial cells among them, microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. Read More

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http://dx.doi.org/10.2174/1570161116666180820115726DOI Listing
August 2018
1 Read

Managing Clopidogrel Hypersensitivity without Interrupting Therapy: The Toronto Approach.

Authors:
Asim N Cheema

Curr Vasc Pharmacol 2019 ;17(2):119-122

Division of Cardiology, Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous manifestations in most patients to angioedema in some and a systemic immune response in rare cases. Read More

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http://dx.doi.org/10.2174/1389200219666180820114435DOI Listing
January 2019
2 Reads

The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.

Curr Vasc Pharmacol 2019 ;17(3):222-232

The Section of Cardiology, Department of Medicine, The University of Chicago, Chicago, IL 60637, United States.

Statins, 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors, have been used for decades for the prevention of coronary artery disease and stroke. They act primarily by lowering serum cholesterol through the inhibition of cholesterol synthesis in the liver, which results in the upregulation of low-density lipoprotein receptors in the liver. This results in the removal of low-density lipoproteincholesterol. Read More

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http://www.eurekaselect.com/164752/article
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http://dx.doi.org/10.2174/1570161116666180817155058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378117PMC
January 2019
13 Reads

Clopidogrel Hypersensitivity: Overview of the Problem.

Curr Vasc Pharmacol 2019 ;17(2):108-109

Department of Medicine Sidney Kimmel Medical College at Thomas Jefferson University Co-Director, Cardiac Catheterization Laboratory Director, Interventional Cardiology Fellowship Program Thomas Jefferson University Hospital Philadelphia, PA, United States.

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http://dx.doi.org/10.2174/1570161116666180820123041DOI Listing
January 2019
9 Reads

Regional Distribution of Nitric Oxide Synthase in Human Anorectal Tissue: A Pilot Study on the Potential Role for Nitric Oxide in Haemorrhoids.

Curr Vasc Pharmacol 2018 Jul 29. Epub 2018 Jul 29.

Surgical and Interventional Sciences, Royal Free and University College Medical School, London. United Kingdom.

Objective: To study the distribution of nitric oxide synthase (NOS) isoforms and protein levels in human haemorrhoids and rectal tissue Methods: Protein expression of NOS1, NOS2 and NOS3 were compared between haemorrhoids (n=14) and normal rectal submucosa (n=6) using Western blot analysis. Localisation of all NOS isoforms to specific structures was determined by immunohistochemistry.

Results: Western blot analysis showed median (interquartile range) protein levels of all NOS isoforms were 1. Read More

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http://dx.doi.org/10.2174/1570161116666180730101532DOI Listing
July 2018
4 Reads

Use of Alternative Antiplatelet Agents for Clopidogrel Hypersensitivity.

Curr Vasc Pharmacol 2019 ;17(2):127-132

Department of Pharmacy Services, UK Healthcare, University of Kentucky College of Pharmacy, Lexington, KY 40536, United States.

Clopidogrel is a widely used agent for secondary prevention of vascular events and is a cornerstone of dual antiplatelet therapy in patients with acute coronary syndrome (ACS) post coronary stent implantation. Hypersensitivity reactions to clopidogrel are well documented and may range from localized to systemic in presentation. This can lead to discontinuation of therapy, thus increasing the risk of vascular events. Read More

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http://dx.doi.org/10.2174/1570161116666180730100806DOI Listing
January 2019
1 Read

Treatment of Clopidogrel Hypersensitivity: The Jefferson Approach.

Curr Vasc Pharmacol 2019 ;17(2):123-126

Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107, United States.

Despite the advent of newer antiplatelet therapies, clopidogrel remains the mainstay of treatment for patients with cardiovascular disease, especially those who undergo coronary stent implantation. Hypersensitivity reactions to clopidogrel that develop soon after stenting present a significant clinical challenge. The widespread use of clopidogrel in the management of patients with coronary artery disease necessitates awareness of treatment options in the setting of an allergic reaction. Read More

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http://dx.doi.org/10.2174/1570161116666180730100346DOI Listing
January 2019
2 Reads

Pleiotropic Effects of Statins: Untapped Potential for Statin Pharmacotherapy.

Curr Vasc Pharmacol 2019 ;17(3):239-261

The Ohio State University, College of Medicine, Department of Biological Chemistry and Pharmacology, Columbus, OH 43210, United States.

Background: Statins are effective for primary and secondary prevention of atherosclerotic cardiovascular disease. They also have systemic anti-inflammatory and immunomodulating properties suggesting potential utility for improving clinical outcomes for a wide range of diseases. The literature provides data suggesting benefit in patients with comorbidities associated with contrast-induced nephropathy (CIN), chronic obstructive pulmonary disease (COPD), pneumonia, head injury, neurological disease (e. Read More

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http://dx.doi.org/10.2174/1570161116666180723120608DOI Listing
January 2019
10 Reads

Statins: Are they really all the same?

Curr Vasc Pharmacol 2019 ;17(3):211-212

Cardiovascular Diseases Section "Monsignor Dimiccoli" Hospital Barletta, Italy.

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http://dx.doi.org/10.2174/1570161116666180713120217DOI Listing
January 2019
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Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives.

Curr Vasc Pharmacol 2018 Jul 11. Epub 2018 Jul 11.

First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki. Greece.

There is increasing evidence that menopause is associated with the progression and severity of non-alcoholic fatty liver disease (NAFLD). Estrogen deficiency worsens non-alcoholic steatohepatitis (NASH) in mice models with fatty liver. The prevalence of NAFLD seems to be higher in postmenopausal compared with premenopausal women. Read More

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http://dx.doi.org/10.2174/1570161116666180711121949DOI Listing
July 2018
35 Reads

Statins: Pharmacokinetics, Pharmacodynamics and Cost-Effectiveness Analysis.

Curr Vasc Pharmacol 2019 ;17(3):213-221

Cardiovascular Diseases Section, "Monsignor Dimiccoli" Hospital, Barletta, Italy.

Cardiovascular diseases secondary to atherosclerosis are the primary causes of early death and disability worldwide and dyslipidaemia represents one of the most important modifiable risk factors. Among lipid abnormalities that define it, low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy, since multiple randomized controlled trials have shown the positive impact of its reduction on atherosclerosis development. For their ability to lower LDL-C levels, statins are the most studied drugs in cardiovascular disease prevention, of proven utility in slowing the progression or even determining regression of atherosclerosis. Read More

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http://dx.doi.org/10.2174/1570161116666180706144824DOI Listing
January 2019
19 Reads

Menopausal hormone therapy and cardiovascular risk. Where are we now?

Curr Vasc Pharmacol 2018 Jul 8. Epub 2018 Jul 8.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki. Greece.

Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause <45 years) and premature ovarian insufficiency (POI, defined as age at menopause <40 years) are associated with 1.5-2-fold increase in CVD risk. Read More

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http://dx.doi.org/10.2174/1570161116666180709095348DOI Listing
July 2018
23 Reads

Galectin-3 and arterial stiffness in patients with heart failure: a pilot study.

Curr Vasc Pharmacol 2018 Jul 2. Epub 2018 Jul 2.

1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens. Greece.

Background: Cardiac performance depends on optimum ventriculoarterial coupling which is impaired in patients with heart failure (HF). Galectin-3 is a mediator of myocardial fibrosis and remodeling, and is associated with clinical status in patients with chronic HF. We examined the association of arterial stiffness with galectin-3 levels in patients with HF of ischemic etiology. Read More

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http://dx.doi.org/10.2174/1570161116666180703094919DOI Listing
July 2018
10 Reads

Statins and Elderly: From Clinical Trials to Daily Practice.

Curr Vasc Pharmacol 2019 ;17(3):233-238

Department of Cardiology AOU Maggiore della Carita, Universita del Piemonte Orientale, Novara, Italy.

Elderly patients represent a rising social problem, due to the exponential growth of persons in these age groups and their atherothrombotic burden. The management of this population still raises several challenges, requiring a balance between elevated cardiovascular risk, clinical complexity, frailty and co-morbidities. Statins represent the main pillar in cardiovascular prevention, lowering serum cholesterol and reducing mortality and ischemic events, especially in high-risk patients. Read More

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http://dx.doi.org/10.2174/1570161116666180628145723DOI Listing
January 2019
4 Reads

Diabetes in menopause: risks and management.

Curr Vasc Pharmacol 2018 06 25. Epub 2018 Jun 25.

Division of Endocrinology and Diabetes, Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens. Greece.

The aim of this review is to present, critically appraise and qualitatively synthesize current evidence on the risk of type 2 diabetes mellitus (T2DM) development during menopause, the management of climacteric symptoms in women with T2DM and the management of T2DM in postmenopausal women. Menopause represents the end of reproductive life in women, as a result of ovarian aging. It is characterized by substantial decrease in the endogenous oestrogen concentrations and it is accompanied by alterations in body weight, adipose tissue distribution and energy expenditure, as well as insulin secretion, insulin sensitivity and activity that can predispose to the development of T2DM, independently of, and additively to, aging. Read More

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http://dx.doi.org/10.2174/1570161116666180625124405DOI Listing
June 2018
26 Reads