1,552 results match your criteria Current Urology Reports[Journal]


Comparing Outcomes of Medical Management and Minimally Invasive Surgical Techniques for Lower Urinary Tract Symptoms due to BPH.

Curr Urol Rep 2019 Apr 15;20(6):29. Epub 2019 Apr 15.

Division of Urology, Robert Wood Johnson Medical School, 125 Patterson St, MEB 584A, New Brunswick, NJ, 08901, USA.

Purpose Of Review: Compare outcomes of medical therapy as compared to minimally invasive surgical therapy (MIST) for treatment of bladder outlet obstruction RECENT FINDINGS: Treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) remains largely driven by patient symptomatology with medical therapy or watchful waiting as the first-line management strategies. However, most patients are not adherent to prescribed medical therapies and are hesitant to accept the risks associated with more invasive therapies. Minimally invasive surgical therapies are treatments providing short-term symptom relief superior to medical therapies without the sequela of more invasive procedures. Read More

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http://dx.doi.org/10.1007/s11934-019-0896-2DOI Listing

Outcomes and Long-term Follow-up of Patients with Cystine Stones: a Systematic Review.

Curr Urol Rep 2019 Apr 15;20(6):27. Epub 2019 Apr 15.

Department of Urology, University Hospital Southampton, Southampton, UK.

Purpose Of Review: Cystine stone patients can be difficult to manage with frequent recurrences. We performed a systematic review with a view to assessing interventions, compliance and their long-term outcomes.

Recent Findings: Ten retrospective observational studies (253 patients) assessed the outcomes and long-term follow-up of cystine stone patients. Read More

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http://dx.doi.org/10.1007/s11934-019-0891-7DOI Listing

Improving Operating Room Efficiency.

Curr Urol Rep 2019 Apr 15;20(6):28. Epub 2019 Apr 15.

Division of Urology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Purpose Of Review: Operating rooms are critical financial centers for hospital systems, with surgical care representing about a third of all health care spending. However, not all of the costs are appropriate or necessary, as there are sometimes significant inefficiencies in how operating rooms are utilized.

Recent Findings: Recent innovations utilizing patient-centered data, systems principles from manufacturing industries, and enhanced communication processes have made significant improvements in improving operating room efficiency. Read More

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http://dx.doi.org/10.1007/s11934-019-0895-3DOI Listing

The Role of Urodynamics in the Pre-transplant Evaluation of Renal Transplant.

Curr Urol Rep 2019 Apr 5;20(5):26. Epub 2019 Apr 5.

Department of Urology, University of Southern California, Los Angeles, CA, USA.

Purpose Of Review: The goal of this study is to delineate the role of advanced urologic evaluation with urodynamics prior to renal transplantation. We seek to report on its indications, possible findings, and subsequent treatment pathways.

Recent Findings: This body of literature is largely comprised of retrospective, single-site studies. Read More

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http://dx.doi.org/10.1007/s11934-019-0887-3DOI Listing

Correction to: Enhanced Endoscopy in Bladder Cancer.

Curr Urol Rep 2019 Apr 5;20(5):25. Epub 2019 Apr 5.

Institute of Urology, USC Keck/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Suite 7416, Los Angeles, CA, 90089, USA.

Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest. Read More

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http://dx.doi.org/10.1007/s11934-019-0890-8DOI Listing

Correction to: Transurethral Resection of Bladder Tumors: Improving Quality Through New Techniques and Technologies.

Curr Urol Rep 2019 Apr 4;20(5):24. Epub 2019 Apr 4.

USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089, USA.

Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest. Read More

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http://dx.doi.org/10.1007/s11934-019-0889-1DOI Listing
April 2019
1 Read

Management of Occult Urinary Incontinence with Prolapse Surgery.

Curr Urol Rep 2019 Mar 30;20(5):23. Epub 2019 Mar 30.

University of Pennsylvania Health System and Perelman School of Medicine, Philadelphia, PA, USA.

Purpose Of Review: The purpose of this paper is to review (1) the epidemiology and pathophysiology of pelvic organ prolapse (POP) and occult stress urinary incontinence (SUI), (2) examine the data on combined operative management of POP and occult SUI, (3) discuss the approaches to clinical decision making, and (4) present future therapies.

Recent Findings: Prospective data on many approaches to concomitant treatment of prolapse and occult stress urinary incontinence, such as minimally invasive sacrocolpopexy and midurethral sling, or older approaches that have regained favor among patients and clinicians wishing to avoid synthetic mesh, such as native tissue prolapse repair and pubovaginal sling, are limited. Safe durable treatments with absorbable graft materials that promote a beneficial host response are intriguing but may be far from clinical implementation. Read More

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http://dx.doi.org/10.1007/s11934-019-0885-5DOI Listing
March 2019
10 Reads

Patient-Reported Outcome Measures (PROMs) in Pelvic Floor Disorders.

Curr Urol Rep 2019 Mar 27;20(5):22. Epub 2019 Mar 27.

Department of Surgery, Division of Urology, University of Cincinnati, 231 Albert Sabin Way, ML 0589, Room#2511, Cincinnati, OH, 45267, USA.

Purpose Of Review: Patient-reported outcome measures (PROMs) are tools that are widely used by clinicians and researchers across different medical specialties. In this review, we examine the use of PROMs in the evaluation of female pelvic floor disorders (PFD).

Recent Findings: PROM development in the assessment of urinary incontinence is more advanced than other pelvic disorders. Read More

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http://dx.doi.org/10.1007/s11934-019-0888-2DOI Listing
March 2019
1 Read

Knowledge Gaps in Urologic Care of Female Spinal Cord Injury Patients.

Curr Urol Rep 2019 Mar 23;20(5):21. Epub 2019 Mar 23.

Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Ste 1100, Philadelphia, PA, 19107, USA.

Purpose Of Review: We highlight the substantial gaps in knowledge on urologic care of female spinal cord injury (SCI) patients.

Recent Findings: Males account for approximately 80% of people living with SCI in developed nations. Although there is a robust body of literature in some aspects of urologic care of individuals with SCI, such as treatments for neurogenic detrusor overactivity, there are relatively few studies focusing specifically on females. Read More

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http://dx.doi.org/10.1007/s11934-019-0884-6DOI Listing
March 2019
1 Read

Application of TAP Block in Laparoscopic Urological Surgery: Current Status and Future Directions.

Curr Urol Rep 2019 Mar 23;20(5):20. Epub 2019 Mar 23.

Department of Surgery, Division of Urology, University of Pennsylvania, 51 N 39th St, MOB 300, Philadelphia, PA, 19104, USA.

Purpose Of Review: Amid the opioid crisis, postoperative pain management is a major challenge for practitioners. Recent pain management guidelines emphasize the importance of using regional anesthesia as part of opioid-sparing multimodal analgesia. This report aims to review recent evidence regarding the utilization of transversus abdominis plane (TAP) block in minimally invasive urologic surgery. Read More

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http://dx.doi.org/10.1007/s11934-019-0883-7DOI Listing
March 2019
2 Reads

Understanding the Link Between Gut Microbiome and Urinary Stone Disease.

Curr Urol Rep 2019 Mar 22;20(5):19. Epub 2019 Mar 22.

Department of Urology, Montefiore Medical Center, 1250 Waters Place - Tower 2 - 9th floor, Bronx, NY, 10461, USA.

Purpose Of Review: With recent advances in sequencing technologies and increasing research into the gut microbiome (GMB), studies have revealed associations between the GMB and urinary stone disease (USD). We sought to determine whether the evidence pointed towards a few specific gut bacteria or the broader GMB network is seemingly responsible for this relationship.

Recent Findings: Initially, Oxalobacter formigenes (OF) was pursued as the main link between GMB and USD given its ability to degrade oxalate in the gut. Read More

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http://dx.doi.org/10.1007/s11934-019-0882-8DOI Listing

Inflatable Penile Prosthesis: Considerations in Revision Surgery.

Curr Urol Rep 2019 Mar 20;20(4):18. Epub 2019 Mar 20.

Duke University Division of Urologic Surgery, 3480 Wake Forest Rd., Suite 506, Raleigh, NC, 27609, USA.

Purpose Of Review: To provide an evidence based discussion of preoperative, intraoperative, and postoperative factors that lead to successful outcomes in penile prosthesis surgery.

Recent Findings: In the preoperative period, careful patient selection, appropriate counseling, thorough evaluation, and sufficient time for physical and emotional adaptation to an inflatable penile prosthesis are the key. During surgery, the entire device should be explanted whenever possible. Read More

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http://dx.doi.org/10.1007/s11934-019-0881-9DOI Listing
March 2019
2 Reads

Innovating Incrementally: Development of the Modern Inflatable Penile Prosthesis.

Curr Urol Rep 2019 Mar 7;20(4):17. Epub 2019 Mar 7.

University of North Carolina-Chapel Hill, 2105 Physician's Office Building, 170 Manning Drive, Chapel Hill, NC, 27599, USA.

Purpose Of Review: The inflatable penile prosthesis (IPP) was introduced in 1973. Since that time, the fundamental design of the IPP has not changed, but numerous improvements to the device, surgery, and peri-operative management have resulted in a modern IPP with excellent reliability, infection control, safety profile, and user experience.

Recent Findings: We describe important modifications to the IPP and review available data assessing the impact of these changes. Read More

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http://link.springer.com/10.1007/s11934-019-0880-x
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http://dx.doi.org/10.1007/s11934-019-0880-xDOI Listing
March 2019
6 Reads

Simultaneous Bilateral Endoscopic Surgery (SBES) for Bilateral Urolithiasis: the Future? Evidence from a Systematic Review.

Curr Urol Rep 2019 Feb 21;20(3):15. Epub 2019 Feb 21.

Department of Urology, University Hospital Southampton NHS Trust, Southampton, SO16 6YD, UK.

Purpose Of Review: Urolithiasis is a disease of prevalence across the world and up to a quarter of patients present with multiple stones. Most procedures carried out in this scenario are staged; however, there is a growing body of evidence to suggest bilateral simultaneous (BS) procedures are safe. We performed a systematic review to investigate and evaluate the evidence for these procedures. Read More

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http://dx.doi.org/10.1007/s11934-019-0877-5DOI Listing
February 2019
2 Reads

'Negative Ureteroscopy' for Stone Disease: Evidence from a Systematic Review.

Curr Urol Rep 2019 Feb 7;20(3):13. Epub 2019 Feb 7.

Department of Urology, University Hospital Southampton NHS Trust, Southampton, UK.

Purpose Of Review: While ureteroscopy (URS) is a common procedure for ureteric stones, this window between diagnosis and treatment leaves the possibility for a 'negative', 'stoneless' or 'diagnostic' URS. We perform a systematic review to look at the rate of 'negative ureteroscopy' and risk factors associated with it.

Recent Findings: From a total of 3599 articles and 68 abstracts, 4 studies (1336 patients) were selected. Read More

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http://dx.doi.org/10.1007/s11934-019-0878-4DOI Listing
February 2019

Optimizing Outcomes in the Virgin Penile Implant Patient.

Authors:
Charles Welliver

Curr Urol Rep 2019 Feb 7;20(3):14. Epub 2019 Feb 7.

, Albany, USA.

Purpose Of Review: Patient satisfaction with inflatable penile prosthesis (IPP) is an elective procedure that restores erectile function.

Recent Findings: While the return of usable erections is almost always achieved with IPP, patients may still be unhappy with the procedure if the outcome has not met their expectations. Optimizing patient satisfaction and outcomes should incorporate considerations for pre-, intra-, and postoperative factors. Read More

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http://dx.doi.org/10.1007/s11934-019-0876-6DOI Listing
February 2019
3 Reads

Infection Prevention Considerations for Complex Penile Prosthesis Recipients.

Curr Urol Rep 2019 Feb 1;20(3):12. Epub 2019 Feb 1.

Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Purpose Of Review: The purpose of this review is to critically analyze and summarize recent studies in the area of penile prosthesis surgery outcomes with a focus on infection prevention in high-risk patients.

Recent Findings: Reduction of surgical time in complex prosthesis surgery may reduce infection risk. Concomitant implant surgery is not associated with increased infection risk. Read More

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http://dx.doi.org/10.1007/s11934-019-0875-7DOI Listing
February 2019
1 Read

A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation.

Curr Urol Rep 2019 Jan 30;20(2):11. Epub 2019 Jan 30.

Department of Urology, University of Miami Miller School of Medicine, 1120 NW 14th Street, 15th Floor, Miami, FL, 33136, USA.

Purpose Of Review: Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to advances in antibiotic dips targeting the skin flora. Read More

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http://dx.doi.org/10.1007/s11934-019-0874-8DOI Listing
January 2019
1 Read

A Contemporary Evaluation of Peyronie's Disease During Penile Prosthesis Placement: MOST, MUST, and More.

Curr Urol Rep 2019 Jan 30;20(2). Epub 2019 Jan 30.

Division of Urology and Urologic Oncology, City Of Hope, 1500 East Duarte Ave, Duarte, CA, 91010, USA.

Purpose Of Review: The use of penile implant for the treatment of both erectile dysfunction and Peyronie's disease has changed little in the last 40 years, primarily limited to modeling and plaque incision. In the current review, I explore the history of Peyronie's treatment at the time of penile prosthesis placement and explore new surgical options that help resolve several of the issues that were not treated with the traditional approaches.

Recent Findings: Advancements have been made in the area of graft material, lengthening procedures, and transcorporal techniques. Read More

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http://dx.doi.org/10.1007/s11934-019-0870-zDOI Listing
January 2019
2 Reads

Damage Control Considerations During IPP Surgery.

Curr Urol Rep 2019 Jan 30;20(2):10. Epub 2019 Jan 30.

Department of Urology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose Of Review: This review summarizes the latest reports in inflatable penile prosthesis (IPP) complication management.

Recent Findings: IPP complications are rare, and reports are limited to retrospective studies. However, recent multi-institutional studies and use of national databases have provided further insight into risk factors for complications. Read More

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http://link.springer.com/10.1007/s11934-019-0872-x
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http://dx.doi.org/10.1007/s11934-019-0872-xDOI Listing
January 2019
5 Reads

Penile Implant Considerations in the Bladder Cancer Survivor.

Curr Urol Rep 2019 Jan 28;20(2). Epub 2019 Jan 28.

Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089-9178, USA.

Purpose Of Review: After radical cystoprostatectomy, patients often develop erectile dysfunction refractory to first- and second-line treatments. In this review, we summarize and analyze the literature describing the technical considerations and outcomes of penile implant surgery in bladder cancer patients with history of radical cystectomy and urinary diversion.

Recent Findings: Penile prosthesis surgery in patients after radical cystectomy and urinary diversion has been infrequently described in the literature. Read More

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http://dx.doi.org/10.1007/s11934-019-0873-9DOI Listing
January 2019
1 Read

Reservoir Placement Considerations During Inflatable Penile Prosthesis Surgery.

Authors:
Steven J Hudak

Curr Urol Rep 2019 Jan 28;20(2). Epub 2019 Jan 28.

Urology Clinic, Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., JBSA Fort Sam Houston, San Antonio, TX, 78234, USA.

Purpose Of Review: To discuss emerging alternative strategies for reservoir placement during inflatable penile prosthesis surgery.

Recent Findings: Innovations in penile prosthesis design have facilitated the development of various alternative approaches for reservoir placement. Avoiding the space of Retzius is particularly appealing in patients with a history of pelvic surgery and/or radiation. Read More

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http://dx.doi.org/10.1007/s11934-019-0871-yDOI Listing
January 2019

Use of Mannitol for Ischemia Reperfusion Injury in Kidney Transplant and Partial Nephrectomies-Review of Literature.

Curr Urol Rep 2019 Jan 26;20(1). Epub 2019 Jan 26.

Department of Nephrology, University of Oklahoma, Tulsa, OK, USA.

Purpose Of Review: Few procedures involve the ischemia-reperfusion injury to organs purposely. Two clear examples in urologic surgery consist on kidney transplantation and partial nephrectomies.

Recent Findings: Mannitol is an osmotic diuretic that is commonly used in partial nephrectomies and kidney transplantation to increase renal blood flow and decrease warm-ischemia-related renal injury to preserve estimated glomerular filtration rate (eGFR). Read More

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http://dx.doi.org/10.1007/s11934-019-0868-6DOI Listing
January 2019
8 Reads

Imaging of Unusual Renal Tumors.

Curr Urol Rep 2019 Jan 21;20(1). Epub 2019 Jan 21.

Department of Radiology, University of Miami/Miller School of Medicine, 1611 NW 12th Avenue, Miami, FL, 33136, USA.

Purpose Of Review: Renal masses are a wide entity and a common finding in clinical practice. Detection of these masses has increased in the last years, yet mortality rates have slightly decreased.

Recent Findings: According to the World Health Organization classification, there are 8 types, 51 subtypes, and a lot more subsequent subclassifications of renal tumors. Read More

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http://link.springer.com/10.1007/s11934-019-0867-7
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http://dx.doi.org/10.1007/s11934-019-0867-7DOI Listing
January 2019
8 Reads

Renal Medullary Carcinoma: a Report of the Current Literature.

Curr Urol Rep 2019 Jan 17;20(1). Epub 2019 Jan 17.

FINAER (Foundation for Research and Assistance in Kidney Disease), Palestina 525, 1182, Buenos Aires, Argentina.

Purpose Of The Review: We present an updated report of renal medullary carcinoma (RMC), a rare and aggressive condition.

Recent Findings: There is a majority of male patients, of African descent, in the second or third decade of life. In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties. Read More

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http://dx.doi.org/10.1007/s11934-019-0865-9DOI Listing
January 2019
4 Reads

Surgical Treatment of Completely Endophytic Renal Tumor: a Systematic Review.

Curr Urol Rep 2019 Jan 16;20(1). Epub 2019 Jan 16.

Department of Urology, La Fe Hospital, Fernando Abril Martorell 106, 46026, Valencia, Spain.

Purpose Of Review: An endophytic renal tumor represents a special surgical challenge in terms of location and safe removal. For this reason we wanted to review the existing literature on this subject.

Recent Findings: In high-activity robotic centers, robot-assisted partial nephrectomy (RAPN) is a safe and efficacious surgical approach for completely endophytic renal tumors. Read More

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http://dx.doi.org/10.1007/s11934-019-0864-xDOI Listing
January 2019
3 Reads

Vascular Injury During Urologic Surgery: Somebody Call My Mother.

Curr Urol Rep 2019 Jan 16;20(1). Epub 2019 Jan 16.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, C/ Doctor Esquerdo, 46, 28007, Madrid, Spain.

Purpose Of Review: To provide the critical elements to effectively manage hemorrhage from vascular injuries sustained during planned urological interventions.

Recent Findings: The frequency of intraoperative vascular injuries is increasing. However, literature concerning the management of iatrogenic operative vascular injuries is scarce. Read More

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http://dx.doi.org/10.1007/s11934-019-0869-5DOI Listing
January 2019
2 Reads

A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma.

Curr Urol Rep 2019 Jan 15;20(1). Epub 2019 Jan 15.

Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain.

Purpose Of Review: Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life.

Recent Findings: Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. Read More

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http://link.springer.com/10.1007/s11934-019-0866-8
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http://dx.doi.org/10.1007/s11934-019-0866-8DOI Listing
January 2019
10 Reads

Use of Dynamic MRI of the Pelvic Floor in the Assessment of Anterior Compartment Disorders.

Curr Urol Rep 2018 Nov 13;19(12):112. Epub 2018 Nov 13.

Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 3140C, Baltimore, MD, 21287, USA.

Purpose Of Review: Approximately 25% of women in the USA suffer from pelvic floor disorders. Disorders of the anterior compartment of the pelvic floor, in particular, can cause symptoms such as incomplete urinary voiding, urinary incontinence, pelvic organ prolapse, dyspareunia, and pelvic pain, potentially negatively impacting a woman's quality of life. In some clinical situations, clinical exam alone may be insufficient, especially when patient's symptoms are in excess of their pelvic exam findings. Read More

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http://link.springer.com/10.1007/s11934-018-0862-4
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http://dx.doi.org/10.1007/s11934-018-0862-4DOI Listing
November 2018
25 Reads

Bladder Cancer Survivorship.

Curr Urol Rep 2018 Nov 9;19(12):111. Epub 2018 Nov 9.

USC/Norris Comprehensive Cancer Center, Keck School of Medicine, USC Institute of Urology, 1441 Eastlake Ave, Suite 7416, Los Angeles, CA, 90094, USA.

Purpose Of Review: Bladder cancer (BC) is the second most common genitourinary malignancy, with a growing population of survivors globally. Over the past two decades, there has been a growing awareness of not only the oncologic, but also the quality of life ramifications of a BC diagnosis, treatment, and surveillance. In the current review, the literature surrounding the many domains that encompass bladder cancer survivorship is summarized and analyzed. Read More

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http://link.springer.com/10.1007/s11934-018-0860-6
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http://dx.doi.org/10.1007/s11934-018-0860-6DOI Listing
November 2018
12 Reads

Molecular Imaging for Evaluation of Viable Testicular Cancer Nodal Metastases.

Curr Urol Rep 2018 Nov 9;19(12):110. Epub 2018 Nov 9.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Marburg 144, Baltimore, MD, 21287, USA.

Purpose Of Review: Determining the metastatic viability of suspicious retroperitoneal nodes in testicular cancer with conventional imaging is challenging. The aim of this report is to review recent evidence in the utilization of novel imaging modalities to assess viable testicular cancer nodal metastases.

Recent Evidence: Testicular germ cell tumors (TCGTs) follow a predictable lymphatic metastatic spread to the retroperitoneum. Read More

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http://link.springer.com/10.1007/s11934-018-0863-3
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http://dx.doi.org/10.1007/s11934-018-0863-3DOI Listing
November 2018
20 Reads

Immunotherapy for Urothelial Carcinoma: Current Evidence and Future Directions.

Curr Urol Rep 2018 Nov 7;19(12):109. Epub 2018 Nov 7.

Division of Genitourinary Medical Oncology, Department of Hematology/Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111-2497, USA.

Purpose Of Review: Until recently, effective treatment options for patients with advanced urothelial carcinoma were limited to platinum-based chemotherapy. In the post-platinum setting and for patients ineligible for cisplatin, minimally effective second-line chemotherapy was used and outcomes were poor. The approval of immune checkpoint inhibitors has significantly changed the treatment landscape of urothelial carcinoma. Read More

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http://link.springer.com/10.1007/s11934-018-0851-7
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http://dx.doi.org/10.1007/s11934-018-0851-7DOI Listing
November 2018
15 Reads

Bladder Preservation Therapy: Review of Literature and Future Directions of Trimodal Therapy.

Curr Urol Rep 2018 Nov 3;19(12):108. Epub 2018 Nov 3.

Department of Surgery, McGill University Health Center, McGill University, 1001 Decarie Blvd, D02.7210, Montreal, QC, H4A 3J1, Canada.

Purpose Of The Review: This review targets the latest literature on bladder preservation therapy with emphasis on trimodal therapy (TMT), highlighting its role in the management of muscle invasive bladder cancer (MIBC) and outlining future directions in bladder preservation research.

Recent Findings: TMT is the most promising bladder preservation treatment modality. Comparable results to contemporary radical cystectomy series are seen in properly selected patients. Read More

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http://link.springer.com/10.1007/s11934-018-0859-z
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http://dx.doi.org/10.1007/s11934-018-0859-zDOI Listing
November 2018
12 Reads

Molecular Characterization of Bladder Cancer.

Curr Urol Rep 2018 Nov 3;19(12):107. Epub 2018 Nov 3.

Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University of Toronto and University Health Network, Toronto, ON, Canada.

Purpose Of Review: Bladder cancer (BCa) management had remained unchanged for 20+ years with clinicians, in contrast to many other cancer types, rarely relying on molecular characteristics to guide management. The past 5 years have yielded significant advances in our knowledge of the molecular basis of BCa and concurrent advances in systemic therapy. We aim to highlight the key developments and potential future direction of BCa management. Read More

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http://link.springer.com/10.1007/s11934-018-0853-5
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http://dx.doi.org/10.1007/s11934-018-0853-5DOI Listing
November 2018
18 Reads

Management of Lower Urinary Tract Symptoms After Pelvic Radiation in Females.

Authors:
Laura S Leddy

Curr Urol Rep 2018 Oct 31;19(12):106. Epub 2018 Oct 31.

Memorial Sloan-Kettering Cancer Center, 353 East 68th Street, New York, NY, 10065, USA.

Purpose Of Review: To present the available literature pertaining to the management of lower urinary tract symptoms (LUTS) after pelvic radiation (RT) in female patients treated for pelvic malignancy.

Recent Findings: Recent publications have focused on isolating de novo RT-induced LUTS in women from other contributors to urinary symptoms such as pelvic surgery and chemotherapy. There is a paucity of literature on the treatment of RT-related changes to urinary function. Read More

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http://dx.doi.org/10.1007/s11934-018-0848-2DOI Listing
October 2018
2 Reads

Patient-Centered Outcomes in Bladder Cancer.

Authors:
John L Gore

Curr Urol Rep 2018 Oct 29;19(12):105. Epub 2018 Oct 29.

Department of Urology, Seattle Cancer Care Alliance, University of Washington, 1959 NE Pacific St, Box 356510, Seattle, WA, 98195, USA.

Purpose Of Review: To summarize current knowledge on patient-prioritized outcomes for their bladder cancer care.

Recent Findings: Patient-centered outcomes research seeks to help patients identify the right treatment for the right patient at the right time in their care. As such, patient-centered outcomes research relies on studying a treatment's impact on patient-centered outcomes. Read More

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http://link.springer.com/10.1007/s11934-018-0858-0
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http://dx.doi.org/10.1007/s11934-018-0858-0DOI Listing
October 2018
3 Reads

Preventing Lethal Prostate Cancer with Diet, Supplements, and Rx: Heart Healthy Continues to Be Prostate Healthy and "First Do No Harm" Part I.

Authors:
Mark A Moyad

Curr Urol Rep 2018 Oct 27;19(12):104. Epub 2018 Oct 27.

University of Michigan Medical Center, Ann Arbor, MI, USA.

Purpose Of Review: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention.

Recent Findings: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, but heart unhealthy is prostate unhealthy. Read More

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http://link.springer.com/10.1007/s11934-018-0846-4
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http://dx.doi.org/10.1007/s11934-018-0846-4DOI Listing
October 2018
4 Reads

Management of High-grade T1 Urothelial Carcinoma.

Curr Urol Rep 2018 Oct 26;19(12):103. Epub 2018 Oct 26.

Department of Urology, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, TN, 37232, USA.

Purpose Of Review: The optimal management of high-grade T1 (HGT1) urothelial carcinoma (UC) is complex given its high rate of recurrence, progression, and cancer-specific mortality as well as its clinical variability. Our current treatment paradigm has been supplemented by recent data describing the expanding options for salvage intravesical therapy, bladder preservation, and the promising role of molecular epidemiology. In the current review, we attempt to summarize and critically analyze these studies. Read More

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http://link.springer.com/10.1007/s11934-018-0850-8
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http://dx.doi.org/10.1007/s11934-018-0850-8DOI Listing
October 2018
20 Reads

Performance Measurement and Quality Improvement Initiatives for Bladder Cancer Care.

Curr Urol Rep 2018 Oct 24;19(12):100. Epub 2018 Oct 24.

Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Purpose Of Review: Bladder cancer care is costly due to long surveillance periods for non-muscle-invasive bladder cancer (NMIBC) and comorbidities associated with the surgical treatment of muscle-invasive bladder cancer (MIBC). We reviewed current evidence-based practices and propose quality metrics for NMIBC and MIBC.

Recent Findings: For patients with NMIBC, we propose four categories of candidate quality metrics: (1) appropriate use of imaging, (2) re-staging transurethral resection of bladder tumor, (3) perioperative intravesical chemotherapy, and (4) induction and maintenance BCG in high-risk NMIBC. Read More

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http://link.springer.com/10.1007/s11934-018-0856-2
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http://dx.doi.org/10.1007/s11934-018-0856-2DOI Listing
October 2018
17 Reads

Current Clinical Trials in Non-muscle Invasive Bladder Cancer.

Curr Urol Rep 2018 Oct 24;19(12):101. Epub 2018 Oct 24.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Level 6, 2775 Laurel St, Vancouver, BC, V6N 2W6, Canada.

Purpose Of Review: As our molecular understanding of bladder cancer continues to advance, more and more novel agents are entering clinical trials across the spectrum of bladder cancer stages. The clinical trial activity for non-muscle invasive bladder cancer (NMIBC) has been boosted further by the evolution of specific disease states that set more uniform inclusion criteria for clinical trial design. Here, we aimed to review the current clinical trials landscape in non-muscle invasive bladder cancer with respect to these disease states. Read More

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http://link.springer.com/10.1007/s11934-018-0852-6
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http://dx.doi.org/10.1007/s11934-018-0852-6DOI Listing
October 2018
18 Reads

Epigenetic Alterations in Bladder Cancer.

Authors:
Sima P Porten

Curr Urol Rep 2018 Oct 24;19(12):102. Epub 2018 Oct 24.

Department of Urology, University of California San Francisco (UCSF), Mailbox Code 1695, 550 16th Street, 6th Floor, San Francisco, CA, 94143, USA.

Purpose Of Review: Epigenetics refers to processes that alter gene expression without altering primary DNA. Over that past decade, there is a growing focus on epigenetic mechanisms in cancer research and its importance in cancer biology. This review summarizes epigenetic dysregulation in bladder cancer. Read More

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http://link.springer.com/10.1007/s11934-018-0861-5
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http://dx.doi.org/10.1007/s11934-018-0861-5DOI Listing
October 2018
14 Reads

Optimizing Nutrition Prior to Radical Cystectomy.

Curr Urol Rep 2018 Oct 18;19(12):99. Epub 2018 Oct 18.

Department of Urology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr., 3RCP, Iowa City, IA, 52243-1089, USA.

Purpose Of Review: Malnutrition in a prevalent problem in patients undergoing radical cystectomy. Preoperative malnutrition has been shown to contribute to increased rates of postoperative complications. Given the significant morbidity and mortality of the procedure of radical cystectomy, there is potential for improvement in patient outcomes by nutritional intervention. Read More

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http://link.springer.com/10.1007/s11934-018-0854-4
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http://dx.doi.org/10.1007/s11934-018-0854-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329587PMC
October 2018
5 Reads

An Update in Enhanced Recovery Following Radical Cystectomy.

Curr Urol Rep 2018 Oct 18;19(12):98. Epub 2018 Oct 18.

Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089, USA.

Purpose Of Review: The purpose of the study is to review and summarize major additions to the literature as pertains to enhanced recovery protocols after radical cystectomy in the past year.

Recent Findings: Enhanced recovery after surgery protocols is multimodal pathways that include elements to optimize all stages of care including preoperative, intraoperative and postoperative measures. Several authors have recently presented their results with initial implementation of an enhanced recovery protocol after radical cystectomy, while others have begun to examine outcomes beyond the index admission and to refine the various targeted components of the protocol. Read More

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http://dx.doi.org/10.1007/s11934-018-0855-3DOI Listing
October 2018
1 Read

Patient Distress in Women with Recurrent Urinary Tract Infections: How Can Physicians Better Meet Patients Needs?

Curr Urol Rep 2018 Oct 18;19(12):97. Epub 2018 Oct 18.

Section of Urology and Renal Transplantation, Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Recurrent urinary tract infections are a common condition that can impact patients' quality of life. The purpose of this review is to summarize and analyze the literature regarding the distress that these infections can cause to patients and provide guidance to clinicians on how to improve care of these patients.

Recent Findings: The current literature on patient perspectives in urinary tract infections shows an emotional symptom experience that is not consistent with the typical symptoms expected by clinicians. Read More

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http://dx.doi.org/10.1007/s11934-018-0849-1DOI Listing
October 2018
1 Read

Current Use and Promise of Urinary Markers for Urothelial Cancer.

Curr Urol Rep 2018 Oct 17;19(12):96. Epub 2018 Oct 17.

The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1373, Houston, TX, 77030, USA.

Purpose Of Review: We summarize the current literature regarding the available urinary biomarkers for the detection and surveillance of bladder cancer.

Recent Findings: Four urinary biomarkers have FDA approval for the detection of bladder cancer; however, they have not supplanted cystoscopy and urine cytology as the gold standard. Recent technological advances in next-generation sequencing have allowed the field of urinary biomarker research to move beyond protein biomarkers and now include genomic, transcriptomic, and epigenetic panels. Read More

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http://link.springer.com/10.1007/s11934-018-0857-1
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http://dx.doi.org/10.1007/s11934-018-0857-1DOI Listing
October 2018
11 Reads

Management of Overactive Bladder Symptoms After Radical Prostatectomy.

Curr Urol Rep 2018 Oct 10;19(12):95. Epub 2018 Oct 10.

Department of Urology, New York University, New York, NY, USA.

Purpose Of Review: Post-prostatectomy overactive bladder (OAB) is a common and challenging condition to manage. The aim of the present report was to review the recent evidences regarding OAB symptoms that develop in men after prostatectomy and how to manage them.

Recent Findings: The prevalence of OAB after radical prostatectomy may range from 15. Read More

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http://link.springer.com/10.1007/s11934-018-0847-3
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http://dx.doi.org/10.1007/s11934-018-0847-3DOI Listing
October 2018
4 Reads

Recurrent Urinary Tract Infections in Females and the Overlap with Overactive Bladder.

Curr Urol Rep 2018 Sep 13;19(11):94. Epub 2018 Sep 13.

Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Purpose Of Review: There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Read More

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http://link.springer.com/10.1007/s11934-018-0839-3
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http://dx.doi.org/10.1007/s11934-018-0839-3DOI Listing
September 2018
45 Reads

Use of MR Urography in Pediatric Patients.

Curr Urol Rep 2018 Sep 11;19(11):93. Epub 2018 Sep 11.

Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Purpose Of Review: In this article, we describe the basics of how magnetic resonance urography (MRU) is performed in the pediatric population as well as the common indications and relative performance compared to standard imaging modalities.

Recent Findings: Although MRU is still largely performed in major academic or specialty imaging centers, more and more applications in the pediatric setting have been described in the literature. MRU is a comprehensive imaging modality for evaluating multiple pediatric urologic conditions combining excellent anatomic detail with functional information previously only available via renal scintigraphy. Read More

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http://dx.doi.org/10.1007/s11934-018-0843-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132788PMC
September 2018
2 Reads

Management of Overactive Bladder in Older Women.

Curr Urol Rep 2018 Sep 10;19(11):92. Epub 2018 Sep 10.

University of California, San Francisco, 400 Parnassus Avenue, Box 0738, San Francisco, CA, 94143, USA.

Purpose Of Review: This review will highlight our current understanding of age-related changes in bladder function and propose important clinical considerations in the management of overactive bladder (OAB) specific to older women.

Recent Findings: Frailty, functional and cognitive impairment, multimorbidity, polypharmacy, estrogen deficiency, and remaining life expectancy are important clinical factors to consider and may impact OAB symptom management in older women. Third-line therapies, particularly PTNS, may be preferable over second-line therapy in some cases. Read More

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http://dx.doi.org/10.1007/s11934-018-0845-5DOI Listing
September 2018
5 Reads