1,025 results match your criteria Current Treatment Options in Neurology[Journal]


Status Epilepticus in the Neonate: Updates in Treatment Strategies.

Curr Treat Options Neurol 2019 Feb 18;21(2). Epub 2019 Feb 18.

Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, 611 E Livingston Avenue FB4, Columbus, OH, 43205, USA.

Purpose Of Review: The purpose of this review is to report recent advances in treatment of neonatal seizures, with a specific focus on new literature since a 2013 systematic review performed by this author (Slaughter) and others. There is a paucity of data with regard to well-defined status epilepticus (SE) in neonates, so treatment of recurrent seizures was also included in this inquiry. We aimed to summarize the efficacy and safety profiles of current therapeutic options as well as describe trends in medication selection in the neonatal intensive care unit (NICU) setting. Read More

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http://dx.doi.org/10.1007/s11940-019-0546-5DOI Listing
February 2019

Risk Factors for Sudden Unexpected Death in Epilepsy (SUDEP) and Their Mitigation.

Curr Treat Options Neurol 2019 Feb 13;21(2). Epub 2019 Feb 13.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

Purpose Of Review: People with epilepsy have an increased risk of mortality when compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related death in children and adults. The purpose of this review is to discuss SUDEP, with an emphasis on SUDEP risk factors, their mitigation and prevention. Read More

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http://link.springer.com/10.1007/s11940-019-0547-4
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http://dx.doi.org/10.1007/s11940-019-0547-4DOI Listing
February 2019
4 Reads

Stereotactic Radiosurgery for Multiple Brain Metastases.

Curr Treat Options Neurol 2019 Feb 13;21(2). Epub 2019 Feb 13.

Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Purpose Of Review: To give an overview on the current evidence for stereotactic radiosurgery of brain metastases with a special focus on multiple brain metastases.

Recent Findings: While the use of stereotactic radiosurgery in patients with limited brain metastases has been clearly defined, its role in patients with multiple lesions (> 4) is still a matter of controversy. Whole-brain radiation therapy (WBRT) has been the standard treatment approach for patients with multiple brain lesions and is still the most commonly used treatment approach worldwide. Read More

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http://dx.doi.org/10.1007/s11940-019-0548-3DOI Listing
February 2019

Treatment and Outcomes in Nutritional Optic Neuropathy.

Curr Treat Options Neurol 2019 Feb 7;21(1). Epub 2019 Feb 7.

Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.

Purpose Of Review: Nutritional optic neuropathy is a potential cause of severe visual loss; however, appropriate and timely management can result in excellent visual outcomes. The purpose of this review is to outline our current understanding of the treatment and outcomes for nutritional optic neuropathy.

Recent Findings: Current understanding of nutritional optic neuropathy has been greatly aided by some well-reported and investigated epidemics of the condition, most notably the Cuban epidemic optic neuropathy of the early 1990s. Read More

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http://dx.doi.org/10.1007/s11940-019-0542-9DOI Listing
February 2019
1 Read

Sleep Abnormalities in Multiple Sclerosis.

Curr Treat Options Neurol 2019 Jan 31;21(1). Epub 2019 Jan 31.

Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.

Purpose Of Review: This review summarizes the most well-documented sleep disorders seen in patients with multiple sclerosis (MS), with a special focus on the impact on quality of life.

Recent Findings: Sleep abnormalities in patients with MS are a multifactorial and relatively complex issue affecting approximately 60% of the patients while the pathophysiology of these symptoms is not fully understood. Circadian rhythm disorders and increased levels of pro-inflammatory cytokines have been recognized as potential players in affecting sleep homeostasis in MS patients. Read More

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http://dx.doi.org/10.1007/s11940-019-0544-7DOI Listing
January 2019
1 Read

Advances in Management of Psychosis in Neurodegenerative Diseases.

Curr Treat Options Neurol 2019 Jan 23;21(1). Epub 2019 Jan 23.

Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 901, New Haven, CT, 06511, USA.

Purpose Of The Review: Psychosis is broadly defined as a disengagement from reality. It describes syndromes that impair both thought content and thought process. Psychosis negatively impacts an individual's quality of life, in addition to the families caring for them. Read More

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http://dx.doi.org/10.1007/s11940-019-0545-6DOI Listing
January 2019
4 Reads

Treatment Approaches for MOG-Ab-Associated Demyelination in Children.

Curr Treat Options Neurol 2019 Jan 22;21(1). Epub 2019 Jan 22.

Department of Neurology and Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Purpose Of Review: The purpose of this review is to summarize current understanding regarding the treatment of myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated demyelination in children. Emphasis is placed on the unique obstacles we face when predicting the risk of relapse and the important implications of such challenges when planning treatment protocols.

Recent Findings: MOG-Abs are consistently identified in a range of acquired demyelinating syndromes (ADS) in adults and children with a clinical phenotype distinct of MS and AQP4-Ab neuromyelitis optica spectrum disorder. Read More

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http://dx.doi.org/10.1007/s11940-019-0541-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342853PMC
January 2019

Diagnostic Criteria, Differential Diagnosis, and Treatment of Minor Motor Activity and Less Well-Known Movement Disorders of Sleep.

Curr Treat Options Neurol 2019 Jan 19;21(1). Epub 2019 Jan 19.

Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose Of Review: Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify their pathogenesis and clinical relevance. This review will focus on those minor sleep-related movement disorders. Read More

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http://dx.doi.org/10.1007/s11940-019-0543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339673PMC
January 2019
2 Reads

Restless Legs Syndrome and Other Movement Disorders of Sleep-Treatment Update.

Curr Treat Options Neurol 2018 Nov 9;20(12):55. Epub 2018 Nov 9.

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

Purpose Of Review: The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well as REM sleep behavior disorder (RBD), and periodic leg movement disorder (PLMD).

Recent Findings: Traditionally, dopaminergic therapy has been considered the sole option for first-line treatment of RLS due to their impressive acute efficacy. Dopamine agonists such as oral pramipexole and ropinirole, as well as transdermal rotigotine are all effective treatment options. Read More

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http://link.springer.com/10.1007/s11940-018-0540-3
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http://dx.doi.org/10.1007/s11940-018-0540-3DOI Listing
November 2018
16 Reads

Gastrointestinal Dysfunction in Parkinson's Disease.

Curr Treat Options Neurol 2018 Oct 25;20(12):54. Epub 2018 Oct 25.

Department of Neurology, Oregon Health and Science University, Portland, OR, USA.

Purpose Of Review: During the past 25 years, there has been an explosion of information regarding the occurrence of gastrointestinal dysfunction in Parkinson's disease. In this review, the clinical features of gastrointestinal dysfunction in Parkinson's disease will be described and information regarding the potential role of the enteric nervous system and the gut microbiome in the genesis of Parkinson's disease will be addressed.

Recent Findings: Recognition is growing regarding the role that gastroparesis and small intestinal dysfunction may play in Parkinson's disease, especially with regard to erratic responses to anti-Parkinson medication. Read More

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http://dx.doi.org/10.1007/s11940-018-0539-9DOI Listing
October 2018
2 Reads

Cognitive Deficits in Multiple Sclerosis: Recent Advances in Treatment and Neurorehabilitation.

Curr Treat Options Neurol 2018 Oct 22;20(12):53. Epub 2018 Oct 22.

Neuroscape Center, Weill Institute for the Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Purpose Of Review: This article highlights recent progress in research on treatment and neurorehabilitation of cognitive impairment in multiple sclerosis (MS) including pharmacological interventions, physical exercise, and neuropsychological rehabilitation, both in conventional and technology-assisted settings.

Recent Findings: The most consistent evidence in terms of improvement or preservation of circumscribed cognitive scores in MS patients comes from moderately sampled randomized clinical trials on multimodal approaches that combine conventional or computerized neuropsychological training with psychoeducation or cognitive behavioral therapy. Disease-modifying treatments also appear to have beneficial effects in preventing or attenuating cognitive decline, whereas there is little evidence for agents such as donepezil or stimulants. Read More

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http://link.springer.com/10.1007/s11940-018-0538-x
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http://dx.doi.org/10.1007/s11940-018-0538-xDOI Listing
October 2018
15 Reads

Current Treatment Strategies and Future Treatment Options for Dravet Syndrome.

Curr Treat Options Neurol 2018 Oct 13;20(12):52. Epub 2018 Oct 13.

Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, 13123 E 16th Ave, Aurora, CO, 80045, USA.

Purpose Of Review: Dravet syndrome is a rare but severe genetic epilepsy that has unique treatment challenges. This is a review of current and future potential treatment options.

Recent Findings: Treatment for Dravet syndrome should encompass many aspects of the syndrome such as gait, behavior, and nutrition, as well as focus on seizure control. Read More

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http://link.springer.com/10.1007/s11940-018-0537-y
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http://dx.doi.org/10.1007/s11940-018-0537-yDOI Listing
October 2018
16 Reads

Neurotoxicity of Anesthesia in Children: Prevention and Treatment.

Curr Treat Options Neurol 2018 Oct 13;20(12):51. Epub 2018 Oct 13.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue - Bader 3, Boston, MA, 02115, USA.

Purpose Of Review: The purpose of this review is to summarize the current evidence regarding the impact of the exposure to anesthetic and sedative agents on neurodevelopment during the period of rapid brain growth in the first 3 years of life. Though much of the definitive data demonstrating anesthesia-induced neurotoxicity has come from studies in young animals, the focus of this review is on emerging human data.

Recent Findings: In 2016, the first prospective trials investigating the neurodevelopmental impact of early anesthetic exposure (GAS and PANDA studies) were published, both showing no significant impact on IQ from a single brief anesthetic. Read More

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http://dx.doi.org/10.1007/s11940-018-0536-zDOI Listing
October 2018
1 Read

Treatment of Persistent Postural-Perceptual Dizziness (PPPD) and Related Disorders.

Curr Treat Options Neurol 2018 Oct 13;20(12):50. Epub 2018 Oct 13.

Dizziness and Vertigo Center Essen and Department of Neurology, University of Duisburg-Essen, Essen, Germany.

Purpose Of Review: Persistent postural-perceptual dizziness (PPPD) is a newly defined disorder of functional dizziness that in the International Classification of Diseases in its 11th revision (ICD-11) supersedes phobic postural vertigo and chronic subjective dizziness. Despite efforts to unify the diagnosis of functional (somatoform) dizziness, patients will present with a variety of triggers, perpetuating factors, and comorbidities, requiring individualized treatment. This article will review different treatment strategies for this common functional neurological disorder and provide practical recommendations for tailored therapy. Read More

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http://link.springer.com/10.1007/s11940-018-0535-0
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http://dx.doi.org/10.1007/s11940-018-0535-0DOI Listing
October 2018
40 Reads

Stem Cell Therapy in Cerebrovascular Disease.

Curr Treat Options Neurol 2018 Oct 9;20(11):49. Epub 2018 Oct 9.

Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Purpose Of Review: The purpose of this article is to provide a review of state-of-the-art cellular therapy in cerebrovascular diseases by discussing published and ongoing clinical trials.

Recent Findings: In spite of the challenge in translating the success of cellular therapy in acute strokes from preclinical models to clinical trials, early phase clinical trial have recently shown promise in overcoming these challenges. Various stem cell types and doses are being studied, different routes of administration are under investigation, as well as defining the optimal time window to intervene. Read More

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http://link.springer.com/10.1007/s11940-018-0532-3
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http://dx.doi.org/10.1007/s11940-018-0532-3DOI Listing
October 2018
2 Reads

Sleep, Circadian Rhythms, and Epilepsy.

Curr Treat Options Neurol 2018 Sep 27;20(11):47. Epub 2018 Sep 27.

UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, 312 CIRC, Birmingham, AL, 35294, USA.

Purpose Of Review: There is a known interrelationship between sleep and epilepsy. This review highlights the recent findings regarding interactions between sleep and circadian rhythms and the manifestations of epilepsy and surgical treatments for refractory epilepsy.

Recent Findings: CLOCK gene expression may be reduced within the epileptogenic focus in patients with refractory epilepsy. Read More

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http://dx.doi.org/10.1007/s11940-018-0534-1DOI Listing
September 2018
3 Reads

Novel Systemic Treatments for Brain Metastases From Lung Cancer.

Curr Treat Options Neurol 2018 Sep 27;20(11):48. Epub 2018 Sep 27.

Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Purpose Of Review: Brain metastases are frequent complication of lung cancer and are associated with poor prognosis. Patients with brain metastases secondary to lung cancer have traditionally been managed with surgery and radiation with limited role for systemic chemotherapy. In the past decade, however, this paradigm has shifted largely due to the advent of targeted therapies and immunotherapies, both of which have demonstrated efficacy in the treatment of brain metastases and extracranial disease. Read More

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http://dx.doi.org/10.1007/s11940-018-0533-2DOI Listing
September 2018
8 Reads

Sleep Abnormalities in Wilson's Disease.

Curr Treat Options Neurol 2018 Sep 27;20(11):46. Epub 2018 Sep 27.

French National Reference Centre for Wilson's Disease, University Hospital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

Purpose Of Review: The aim of this article was to review the different sleep disorders associated with Wilson's disease (WD), their mechanisms and their treatments.

Recent Findings: Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder. Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD). Read More

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http://dx.doi.org/10.1007/s11940-018-0531-4DOI Listing
September 2018
3 Reads

Managing Antiepileptic Medication in Dialysis Patients.

Curr Treat Options Neurol 2018 Sep 27;20(11):45. Epub 2018 Sep 27.

Comprehensive Epilepsy Program University of South Florida, Department of Neurology, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA.

Purpose Of Review: The purpose of this review is to summarize and discuss available information on the management of epilepsy patients on renal replacement therapy. Older and newer antiepileptic drugs (AEDs) pharmacology will be reviewed, as well as the need to supplement dosages during or after hemodialysis, peritoneal dialysis, and continuous renal replacement treatment.

Recent Findings: The great majority of anticonvulsants have been studied in patients with renal failure. Read More

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http://link.springer.com/10.1007/s11940-018-0530-5
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http://dx.doi.org/10.1007/s11940-018-0530-5DOI Listing
September 2018
14 Reads

An Update on the Treatment of Chorea.

Curr Treat Options Neurol 2018 Sep 25;20(10):44. Epub 2018 Sep 25.

Veterans Affairs Medical Center, Department of Neurology, Bronx Mount Sinai School of Medicine, New York, NY, 10029, USA.

Purpose Of Review: There are many causes for chorea, including genetic, autoimmune, pharmacological, and structural lesions. Where appropriate, treatment is based on reversing the underlying cause of chorea; many cases are self-limited, resolving when the primary disorder is treated. This review focuses on the management of chorea due to untreatable causes. Read More

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http://dx.doi.org/10.1007/s11940-018-0529-yDOI Listing
September 2018
6 Reads

Cryopyrin-Associated Periodic Fever Syndrome and the Nervous System.

Curr Treat Options Neurol 2018 Sep 3;20(10):43. Epub 2018 Sep 3.

Institute of Neurology, UCL, London, UK.

Purpose Of Review: The purpose of this review is to highlight the molecular and clinical characteristics of the cryopyrin-associated periodic fever syndrome (CAPS) and its management. CAPS is an autosomal dominantly inherited autoinflammatory disorder associated with mutations in the NLRP3 gene, which ultimately lead to excessive production of interleukin-1β (IL-1β) and systemic inflammation. Typical systemic features include fever, urticarial rash and arthralgia, and ultimately amyloidosis. Read More

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http://dx.doi.org/10.1007/s11940-018-0526-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132776PMC
September 2018
7 Reads

Disorders of Vergence Eye Movements.

Curr Treat Options Neurol 2018 Aug 23;20(10):42. Epub 2018 Aug 23.

Departments of Ophthalmology and Neurology, Mayo Clinic Florida, 4500 San Pablo, Jacksonville, FL, 32224, USA.

Purpose Of Review: The purpose of this review is to summarize current understanding regarding disorders of gaze with comitant ocular misalignment at distance or near and a full range of extraocular movement. Emphasis is placed on clinical features that may be used to differentiate underlying neurologic disease from the more common benign causes. The approach to the diagnostic evaluation and treatment is discussed. Read More

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http://link.springer.com/10.1007/s11940-018-0528-z
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http://dx.doi.org/10.1007/s11940-018-0528-zDOI Listing
August 2018
4 Reads

Reducing the Risk of Sudden Unexpected Death in Epilepsy (SUDEP).

Curr Treat Options Neurol 2018 Aug 22;20(10):40. Epub 2018 Aug 22.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro, TR4 9LD, UK.

Purpose Of Review: Recent reports have highlighted an increase in the number of epilepsy-related deaths. Sudden unexpected death in epilepsy (SUDEP) is thought to be the number one cause of death in chronic epilepsy. This review provides a summary of the current evidence of how to communicate, stratify, and mitigate known risk factors for SUDEP. Read More

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http://dx.doi.org/10.1007/s11940-018-0527-0DOI Listing
August 2018
4 Reads
2.175 Impact Factor

Acute Symptomatic Seizures and Provoked Seizures: to Treat or Not to Treat?

Curr Treat Options Neurol 2018 Aug 23;20(10):41. Epub 2018 Aug 23.

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, New York, NY, 10029, USA.

Purpose Of Review: Acute symptomatic and provoked seizures by definition occur in close proximity to an event and are considered to be situational. The treatment implications and likelihood of recurrence of acute symptomatic and provoked seizures differ from unprovoked seizures. In this article, the authors review the literature on acute symptomatic and provoked seizures with regard to therapeutic approach and risk of recurrence. Read More

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http://dx.doi.org/10.1007/s11940-018-0525-2DOI Listing
August 2018
18 Reads

Acute Blood Pressure Management in Acute Ischemic Stroke and Spontaneous Cerebral Hemorrhage.

Curr Treat Options Neurol 2018 Aug 18;20(9):39. Epub 2018 Aug 18.

University of Michigan Stroke Program, Cardiovascular Center, 3rd Floor, Reception C, 1500 East Medical Center Drive, SPC 5855, Ann Arbor, MI, 48109-5855, USA.

Purpose Of Review: We discuss the evidence and guidelines for acute blood pressure (BP) management for patients presenting with acute ischemic stroke or spontaneous cerebral hemorrhage.

Recent Findings: Observational data suggest that the extremes of BP should be avoided in patients presenting with acute ischemic stroke. There is no convincing evidence that active BP reduction results in improved outcomes for ischemic stroke patients. Read More

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http://link.springer.com/10.1007/s11940-018-0523-4
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http://dx.doi.org/10.1007/s11940-018-0523-4DOI Listing
August 2018
24 Reads

Diagnosis and Treatment of Primary Central Nervous System Angiitis.

Curr Treat Options Neurol 2018 Aug 4;20(9):38. Epub 2018 Aug 4.

Neurology, University of Iowa, Iowa City, IA, USA.

Purpose Of Review: Primary central nervous system angiitis (PCNSA) is a rare disease. Varying clinical pictures coupled with lack of sensitive and specific diagnostic tests lead to challenges in management of these patients. This unfortunately may lead to both under- or over-diagnosis and unnecessary treatment. Read More

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http://dx.doi.org/10.1007/s11940-018-0522-5DOI Listing
August 2018
1 Read

Novel Therapeutic Options in Treatment of Idiopathic Inflammatory Myopathies.

Curr Treat Options Neurol 2018 Jul 23;20(9):37. Epub 2018 Jul 23.

Department of Neurology, University of California, Irvine, CA, USA.

Purpose Of Review: The purpose of this review is to update the audience on the recent progress in the treatment of idiopathic inflammatory myopathies, highlighting a myriad of treatment trials aimed at slowing down progression of muscle weakness and/or skin involvement in idiopathic inflammatory myopathies.

Recent Findings: Myositis continues to be an active area of clinical and translational research. Through the work of a number of investigators, we now have a much better understanding of the pathogenesis underlying the various myositides. Read More

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http://dx.doi.org/10.1007/s11940-018-0521-6DOI Listing
July 2018
14 Reads

Orthostatic Tremor: Pathophysiology Guiding Treatment.

Curr Treat Options Neurol 2018 Jul 21;20(9):35. Epub 2018 Jul 21.

Movement Disorders Section, Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.

Purpose Of Review: Orthostatic tremor (OT) is a rare disorder characterized by tremor and a feeling of unsteadiness while standing that resolve upon walking or sitting. A pathognomonic 13-18 Hz tremor is seen on surface EMG while standing. Though its clinical features have been better defined over time, much of its pathophysiology remains unknown and treatment options are limited. Read More

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http://dx.doi.org/10.1007/s11940-018-0524-3DOI Listing
July 2018
1 Read

Congenital Myasthenic Syndromes: a Clinical and Treatment Approach.

Curr Treat Options Neurol 2018 Jul 21;20(9):36. Epub 2018 Jul 21.

Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 2012, Kansas City, KS, 66160, USA.

Purpose Of Review: Congenital myasthenia syndromes are clinically and genetically heterogeneous but treatable conditions. Careful selection of drug therapy is paramount as the same drug can be effective, ineffective, and even harmful in different congenital myasthenia syndromes. The purpose of this article is to review current treatment options for these conditions. Read More

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http://dx.doi.org/10.1007/s11940-018-0520-7DOI Listing
July 2018
17 Reads

Management of Subdural Hematomas: Part II. Surgical Management of Subdural Hematomas.

Curr Treat Options Neurol 2018 Jul 18;20(8):34. Epub 2018 Jul 18.

Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Purpose Of Review: Management of patients with subdural hematomas starts with Emergency Neurological Life Support guidelines. Patients with acute or chronic subdural hematomas (SDHs) associated with rapidly deteriorating neurologic exam, unilaterally or bilaterally dilated nonreactive pupils, and extensor posturing are considered imminently surgical; likewise, SDHs more than 10 mm in size or those associated with more than 5-mm midline shift are deemed operative.

Recent Findings: While twist drill craniostomy and placement of subdural evacuating vport system (SEPS) are quick, bedside procedures completed under local anesthesia and appropriate for patients with chronic SDH or patients that cannot tolerate anesthesia, these techniques are not optimal for patients with acute SDH or chronic SDH with septations. Read More

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http://link.springer.com/10.1007/s11940-018-0518-1
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http://dx.doi.org/10.1007/s11940-018-0518-1DOI Listing
July 2018
22 Reads

What Have We Learned from Recent Clinical Studies in Low-Grade Gliomas?

Curr Treat Options Neurol 2018 Jul 4;20(8):33. Epub 2018 Jul 4.

Department of Neuro-Oncology, University and City of Health and Science, Via Cherasco 15, 10126, Turin, Italy.

Purpose Of Review: The management of low-grade gliomas (grade II WHO) is still controversial, due to the rarity of these tumors and continuous advances in molecular diagnosis and new technologies for treatment. This article reviews the current understanding of management of grade II gliomas in light of the recent clinical and translational studies.

Recent Findings: The role of an extensive surgery at onset is now fully recognized. Read More

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http://dx.doi.org/10.1007/s11940-018-0516-3DOI Listing
July 2018
4 Reads

Anti-IgLON 5 Disease.

Curr Treat Options Neurol 2018 Jun 23;20(8):29. Epub 2018 Jun 23.

Institute for Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Albert-Schweitzer- Campus 1, Building A1, 48149, Muenster, Germany.

Purpose Of Review: This review aims to give an overview about the current knowledge of this novel neurological disorder associated to IgLON-5 antibodies and its treatment.

Recent Findings: Anti-IgLON5 disease was first formally described in 2014. This newly discovered disorder recaps a complex neurological disorder with sleep, movement, and neuroimmunological and neurodegenerative aspects. Read More

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http://dx.doi.org/10.1007/s11940-018-0515-4DOI Listing
June 2018
35 Reads

Antiplatelet Agents in Secondary Stroke Prevention: Selection, Timing, and Dose.

Curr Treat Options Neurol 2018 Jun 23;20(8):32. Epub 2018 Jun 23.

Department of Neurology, Medical University of South Carolina, Charleston, SC, 29425, USA.

Purpose Of Review: This narrative review critically evaluated the published studies regarding the systematic use of antiplatelet agents for secondary stroke prevention.

Recent Findings: Stroke is a leading cause of morbidity and mortality around the world. Multimodal prevention is the most viable strategy for reducing the societal burden of stroke recurrence. Read More

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http://link.springer.com/10.1007/s11940-018-0514-5
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http://dx.doi.org/10.1007/s11940-018-0514-5DOI Listing
June 2018
23 Reads

Treatment of Visual Disorders in Parkinson Disease.

Curr Treat Options Neurol 2018 Jun 23;20(8):30. Epub 2018 Jun 23.

Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, MD, USA.

Purpose Of Review: This article discusses visual disorders in both Parkinson disease (PD) and other Parkinsonian disorders. It is organized largely by the anatomical site of pathology and emphasizes practical treatments. Targeted treatment options include medications, surgery, occupational, and physical therapies as well as optical aids. Read More

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http://dx.doi.org/10.1007/s11940-018-0519-0DOI Listing
June 2018
8 Reads

Current and Emerging Therapies for Duchenne Muscular Dystrophy.

Curr Treat Options Neurol 2018 Jun 23;20(8):31. Epub 2018 Jun 23.

Division of Neurology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Purpose Of Review: The purpose of this review is to summarize the current and emerging therapies for Duchenne muscular dystrophy (DMD).

Recent Findings: Coinciding with new standardized care guidelines, there are a growing number of therapeutic options to treat males with DMD. Treatment of the underlying pathobiology, such as micro-dystrophin gene replacement, exon skipping, stop codon read-through agents, and utrophin modulators showed variable success in animal and human studies. Read More

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http://link.springer.com/10.1007/s11940-018-0513-6
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http://dx.doi.org/10.1007/s11940-018-0513-6DOI Listing
June 2018
12 Reads

Management of Subdural Hematomas: Part I. Medical Management of Subdural Hematomas.

Curr Treat Options Neurol 2018 Jun 23;20(8):28. Epub 2018 Jun 23.

Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Purpose Of Review: Subdural hematomas (SDH) represent common neurosurgical problem associated with significant morbidity, mortality, and high recurrence rates. SDH incidence increases with age; numbers of patients affected by SDH continue to rise with our aging population and increasing number of people taking antiplatelet agents or anticoagulation. Medical and surgical SDH management remains a subject of investigation. Read More

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http://dx.doi.org/10.1007/s11940-018-0517-2DOI Listing
June 2018
8 Reads

Molecular Therapies for Muscular Dystrophies.

Curr Treat Options Neurol 2018 Jun 21;20(7):27. Epub 2018 Jun 21.

Department of Neurology, University of Washington, Box 356465, 1959 NE Pacific Street, Seattle, WA, 98195-6465, USA.

Purpose Of Review: To construct a framework to understand the different molecular interventions for muscular dystrophy.

Recent Findings: The recent approval of antisense oligonucleotides treatment for Duchenne muscular dystrophy and spinal muscular atrophy and current clinical trials using recombinant adeno-associated virus for the treatment of those diseases suggests that we are at a tipping point where we are able to treat and potentially cure muscular dystrophies. Understanding the basic molecular pathogenesis of muscular dystrophies and the molecular biology of the treatment allows for critical evaluation of the proposed therapies. Read More

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http://dx.doi.org/10.1007/s11940-018-0509-2DOI Listing
June 2018
16 Reads

Therapeutic Symptomatic Strategies in the Parasomnias.

Curr Treat Options Neurol 2018 Jun 5;20(7):26. Epub 2018 Jun 5.

Sleep Medicine and Epilepsy Unit, IRCCS Mondino Foundation, Via Mondino, 27100, Pavia, Italy.

Purpose Of Review: The purpose of this review was to discuss the currently available pharmacologic and non-pharmacologic treatment options for parasomnias.

Recent Findings: Recent pathophysiological findings about sleep structure in parasomnias helped understanding several drug mechanisms of action. Serotoninergic theory accounts for the effect of serotoninergic drugs. Read More

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http://dx.doi.org/10.1007/s11940-018-0508-3DOI Listing
June 2018
4 Reads

The Assessment and Management of Peripheral Nerve Trauma.

Authors:
Mark A Ferrante

Curr Treat Options Neurol 2018 Jun 1;20(7):25. Epub 2018 Jun 1.

University of Tennessee Health Science Center, Memphis, TN, USA.

Purpose Of Review: The purpose of this review is to discuss the therapeutic options available in the treatment of traumatic injuries involving peripheral nerves.

Recent Findings: For nerve gap repair, synthetic nerve tubes are limited to gaps below 3 cm in length and to small-diameter nerve repairs, whereas the dependency on proliferating host Schwann cell limits the size of acellularized autografts. Thus, in most situations, nerve autografts remain superior for nerve gap correction. Read More

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http://dx.doi.org/10.1007/s11940-018-0507-4DOI Listing
June 2018
3 Reads

Update on Idiopathic Intracranial Hypertension.

Curr Treat Options Neurol 2018 May 28;20(7):24. Epub 2018 May 28.

Department of Ophthalmology, School of Medicine, University of Colorado Anschutz Medical Campus, 1675 Aurora Court, Mailstop F-731, Aurora, CO, 80045, USA.

Purpose Of Review: This review presents a critical appraisal of current therapeutic strategies for patients with idiopathic intracranial hypertension (IIH). We present the reader with the most recent evidence to support medical and surgical interventions in patients with IIH and provide recommendations about treatment initiation and escalation. We also indicate areas where knowledge gaps exist regarding therapeutic efficacy and superiority of one intervention over another. Read More

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http://dx.doi.org/10.1007/s11940-018-0512-7DOI Listing
May 2018
9 Reads

Current Treatment Options for Peripheral Nerve Hyperexcitability Syndromes.

Curr Treat Options Neurol 2018 May 28;20(7):23. Epub 2018 May 28.

Department of Neurology, Penn State University, 30 Hope Drive, EC 037, Hershey, PA, 17033, USA.

Purpose Of Review: Peripheral nerve hyperexcitability (PNH) syndromes are divided into primary and secondary groups based on the presence or absence of demonstrable peripheral nerve disease. In this review, we systematically evaluate the evidence for current therapies and supportive managements based on autoimmune, paraneoplastic, and genetic components in pathophysiology reported in the literature.

Recent Findings: Current therapy options are based on symptomatic management as well as focusing the underlying immune/genetic/paraneoplastic pathology by immunosuppressants, chemotherapy, and surgery. Read More

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http://dx.doi.org/10.1007/s11940-018-0510-9DOI Listing
May 2018
3 Reads

Surgical Treatment of Adult Moyamoya Disease.

Curr Treat Options Neurol 2018 May 28;20(7):22. Epub 2018 May 28.

Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Purpose Of Review: Moyamoya disease (MMD) is being increasingly diagnosed with the development of radiological surveillance technology and increased accessibility to medical care. Accordingly, there have been several recent reports on treatment outcomes in MMD. In this review, we summarize recent advances in surgical treatment and outcomes of adult MMD, while addressing related controversies. Read More

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http://dx.doi.org/10.1007/s11940-018-0511-8DOI Listing
May 2018
2 Reads

Causes and Treatment of Acute Ischemic Stroke During Pregnancy.

Curr Treat Options Neurol 2018 May 21;20(6):21. Epub 2018 May 21.

Department of Neurology, North Shore University Hospital and Zucker School of Medicine at Hofstra/Northwell, and Feinstein Institute for Medical Research, 300 Community Drive, 9 Tower, Manhasset, NY, 11030, USA.

Purpose Of Review: Treatment recommendations for pregnancy associated ischemic stroke are scarce. This may be due to the fact that, in general, obstetricians tend not to make recommendations for stroke patients and neurologists are not commonly involved in the care of pregnant women. Herein, we review the multiple etiologies of ischemic stroke during pregnancy, considerations for diagnostic testing, and acute treatment and prevention options, including associated risks specific to the pregnant and puerperal state. Read More

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http://dx.doi.org/10.1007/s11940-018-0506-5DOI Listing
May 2018
5 Reads
2.170 Impact Factor

Autoregulation in the Neuro ICU.

Curr Treat Options Neurol 2018 May 17;20(6):20. Epub 2018 May 17.

Department of Neurology, Yale School of Medicine, PO Box 208018, New Haven, CT, 06520, USA.

Purpose Of Review: The purpose of this review is to briefly describe the concept of cerebral autoregulation, to detail several bedside techniques for measuring and assessing autoregulation, and to outline the impact of impaired autoregulation on clinical and functional outcomes in acute brain injury. Furthermore, we will review several autoregulation studies in select forms of acute brain injuries, discuss the potential for its use in patient management in the ICU, and suggest further avenues for research.

Recent Findings: Cerebral autoregulation plays a critical role in regulating cerebral blood flow, and impaired autoregulation has been associated with worse functional and clinical outcomes in various acute brain injuries. Read More

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http://dx.doi.org/10.1007/s11940-018-0501-xDOI Listing
May 2018
2 Reads

Pediatric Neuromyelitis Optica Spectrum Disorders.

Curr Treat Options Neurol 2018 May 2;20(6):19. Epub 2018 May 2.

Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, 55 Fruit Street, ACC708, Boston, MA, 02114, USA.

Purpose Of Review: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD. Read More

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http://link.springer.com/10.1007/s11940-018-0502-9
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http://dx.doi.org/10.1007/s11940-018-0502-9DOI Listing
May 2018
13 Reads

Genotype and Phenotype in Multiple Sclerosis-Potential for Disease Course Prediction?

Curr Treat Options Neurol 2018 Apr 24;20(6):18. Epub 2018 Apr 24.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Purpose Of Review: This review will examine the current evidence that genetic and/or epigenetic variation may influence the multiple sclerosis (MS) clinical course, phenotype, and measures of MS severity including disability progression and relapse rate.

Recent Findings: There is little evidence that MS clinical phenotype is under significant genetic control. There is increasing evidence that there may be genetic determinants of the rate of disability progression. Read More

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http://dx.doi.org/10.1007/s11940-018-0505-6DOI Listing
April 2018
3 Reads

Sleep Abnormalities in MultipleSystem Atrophy.

Curr Treat Options Neurol 2018 Apr 20;20(6):16. Epub 2018 Apr 20.

Pôle sommeil et neurologie, Clinique Beau Soleil, 119 avenue de Lodève, 34070, Montpellier, France.

Purpose Of Review: The purpose of this review was to explore the different sleep disorders associated with MSA, their mechanisms, and their treatments.

Recent Findings: Stridor is a red flag for the diagnosis of MSA. Recent findings show that its presence in early stage of the disease is associated with a reduction in life expectancy. Read More

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http://dx.doi.org/10.1007/s11940-018-0503-8DOI Listing
April 2018
8 Reads

Future Brain and Spinal Cord Volumetric Imaging in the Clinic for Monitoring Treatment Response in MS.

Curr Treat Options Neurol 2018 Apr 20;20(6):17. Epub 2018 Apr 20.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Purpose Of Review: Volumetric analysis of brain imaging has emerged as a standard approach used in clinical research, e.g., in the field of multiple sclerosis (MS), but its application in individual disease course monitoring is still hampered by biological and technical limitations. Read More

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http://dx.doi.org/10.1007/s11940-018-0504-7DOI Listing
April 2018
3 Reads

Ictal Interictal Continuum Patterns.

Curr Treat Options Neurol 2018 Apr 18;20(5):15. Epub 2018 Apr 18.

Department of Neurology. Neurocritical Care Division, Yale University School of Medicine, New Haven, CT, 06520, USA.

Purpose Of Review: To present data available on the epidemiology and significance of rhythmic and periodic patterns that lie on the ictal interictal continuum and propose an algorithm for the clinical approach to patients exhibiting these patterns.

Recent Findings: There is accumulating evidence on the prognostic implications of various rhythmic and periodic patterns in the critically ill population. These patterns are not only associated with increased seizure risk but have also been associated with worse outcome and increased long-term risk of epilepsy in recent studies. Read More

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http://dx.doi.org/10.1007/s11940-018-0500-yDOI Listing
April 2018
3 Reads

Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma?

Curr Treat Options Neurol 2018 Apr 18;20(5):14. Epub 2018 Apr 18.

Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.

Purpose Of Review: More effective therapies for glioblastoma are urgently needed. Immunotherapeutic strategies appear particularly promising and are therefore intensively studied. This article reviews the current understanding of the immunosuppressive glioblastoma microenvironment, discusses the rationale behind various immunotherapies, and outlines the findings of several recently published clinical studies. Read More

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http://dx.doi.org/10.1007/s11940-018-0499-0DOI Listing
April 2018
3 Reads