1,223 results match your criteria Current Treatment Options in Cardiovascular Medicine[Journal]


Virtual Care 2.0-a Vision for the Future of Data-Driven Technology-Enabled Healthcare.

Curr Treat Options Cardiovasc Med 2019 Apr 15;21(5):21. Epub 2019 Apr 15.

Department of Medicine, Divisions of General Internal Medicine and Biomedical Informatics, Chief Medical Information Officer of Population Health, University of California San Diego, 9560 Towne Centre Drive, San Diego, CA, 92121, USA.

A busy community cardiologist finished reading eight echocardiograms over lunch and started clinic at 1 pm. As three patients waited, "Jane," a 45-year-old graphic designer was seen for "skipped heart beat." She works about 50 h a week, exercises at the local gym, and enjoys eating a healthy diet. Read More

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http://link.springer.com/10.1007/s11936-019-0727-2
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http://dx.doi.org/10.1007/s11936-019-0727-2DOI Listing
April 2019
1 Read

Treatment of Heart Failure With Preserved Ejection Fraction (HFpEF): the Phenotype-Guided Approach.

Curr Treat Options Cardiovasc Med 2019 Apr 13;21(4):20. Epub 2019 Apr 13.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

The syndrome of heart failure with preserved ejection (HFpEF) continues to rise in prevalence without persuasive evidence of current pharmacologic interventions that can reduce mortality. Clinical trials thus far have generally enrolled "all-comers" with the clinical syndrome of heart failure and objective evidence of a preserved ejection fraction. However, HFpEF is increasingly understood to be a heterogeneous syndrome likely borne from the interplay of genetic predisposition, lifestyle factors, and high burden of associated comorbidities with each contributing to a variety of incompletely understood pathophysiologic abnormalities. Read More

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http://link.springer.com/10.1007/s11936-019-0709-4
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http://dx.doi.org/10.1007/s11936-019-0709-4DOI Listing
April 2019
3 Reads

Dual Antiplatelet Therapy: How Long Is Long Enough?

Curr Treat Options Cardiovasc Med 2019 Mar 30;21(4):17. Epub 2019 Mar 30.

Cardiology Division, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St GRB 800, Boston, MA, 02114, USA.

Purpose Of Review: The optimal duration of dual antiplatelet therapy (DAPT) has been a topic of considerable interest in recent years, as the risk of stent thrombosis has decreased with newer generation stents and the impact of significant bleeding events on clinical outcomes is increasingly apparent. The purpose of this review is to highlight the landmark studies examining short-duration (6 months or less) and extended-duration (greater than 12 months) DAPT as well as provide information about prediction tools to help guide individualized patient treatment decisions.

Recent Findings: Short-duration DAPT is acceptably safe when clinically necessary, though recent trials demonstrate non-significant trends towards increased risk of ischemic events with shorter durations. Read More

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http://dx.doi.org/10.1007/s11936-019-0721-8DOI Listing
March 2019
1 Read

Extended Reality in Medical Practice.

Curr Treat Options Cardiovasc Med 2019 Mar 30;21(4):18. Epub 2019 Mar 30.

Department of Biomedical Engineering, Washington University in St Louis School of Engineering and Applied Science, 1 Brookings Drive, Campus Box 1097, St. Louis, MO, 63130-4899, USA.

Purpose Of Review: Advances in display technology and computing have led to new devices capable of overlaying digital information onto the physical world or incorporating aspects of the physical world into virtual scenes. These combinations of digital and physical environments are referred to as extended realities. Extended reality (XR) devices offer many advantages for medical applications including realistic 3D visualization and touch-free interfaces that can be used in sterile environments. Read More

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http://dx.doi.org/10.1007/s11936-019-0722-7DOI Listing

Mitral Annular Calcification and Calcific Mitral Stenosis: Therapeutic Challenges and Considerations.

Curr Treat Options Cardiovasc Med 2019 Mar 30;21(4):19. Epub 2019 Mar 30.

Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Yawkey 5E, Boston, MA, 02114, USA.

Purpose Of Review: Mitral annular calcification (MAC) and associated calcific mitral stenosis (MS) are frequent in the aging population, although optimal management remains debated and outcomes are poor. This article summarizes challenges in the diagnosis and therapy of calcific MS, the indications for valve intervention, procedural concerns, and emerging treatment options.

Recent Findings: Surgical mitral valve replacement is the procedure of choice in symptomatic patients at acceptable surgical risk, with transcatheter mitral valve replacement (TMVR) being evaluated in clinical trials as an alternative for patients at prohibitive surgical risk. Read More

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http://link.springer.com/10.1007/s11936-019-0723-6
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http://dx.doi.org/10.1007/s11936-019-0723-6DOI Listing
March 2019
5 Reads

Diagnosis and Pathophysiological Mechanisms of Group 3 Hypoxia-Induced Pulmonary Hypertension.

Curr Treat Options Cardiovasc Med 2019 Mar 22;21(3):16. Epub 2019 Mar 22.

Department of Pediatrics, Washington University School of Medicine, One Children's place, Campus Box 8116-NWT, St. Louis, MO, 63132, USA.

Purpose Of Review: Group 3 hypoxia-induced pulmonary hypertension (PH) is an important and increasingly diagnosed condition in both the pediatric and adult population. The majority of pulmonary hypertension studies to date and all three classes of drug therapies were designed to focus on group 1 PH. There is a clear unmet medical need for understanding the molecular mechanisms of group 3 PH and a need for novel non-invasive methods of assessing PH in neonates. Read More

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http://link.springer.com/10.1007/s11936-019-0718-3
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http://dx.doi.org/10.1007/s11936-019-0718-3DOI Listing
March 2019
5 Reads

Cardiovascular Evaluation of Children With Malignancies.

Curr Treat Options Cardiovasc Med 2019 Mar 11;21(3):14. Epub 2019 Mar 11.

Division of Cardiology, The Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.

Purpose Of Review: The anthracycline (AC) group of drugs is widely used for cancer chemotherapy and has improved outcomes in many childhood malignancies. However, cardiovascular complications are major causes of morbidity and mortality in AC recipients, with the greatest risk factor being a higher cumulative dosage. The purpose of this review is to describe the etio-pathogenesis and risk factors of AC induced cardiotoxicity, with emphasis on currently available and emerging modalities of non-invasive imaging in its surveillance, and to review guidelines on its prevention and treatment. Read More

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http://dx.doi.org/10.1007/s11936-019-0719-2DOI Listing
March 2019
1 Read

Advances in Management of Stable Coronary Artery Disease: the Role of Revascularization?

Curr Treat Options Cardiovasc Med 2019 Mar 11;21(3):15. Epub 2019 Mar 11.

Division of Cardiology, Department of Medicine, Rush University Medical Center, 1717 West Congress Parkway, Suite 307, Kellogg Building, Chicago, IL, 60612, USA.

Purpose Of Review: Coronary artery disease remains the most common cause of death worldwide. In patients with biomarker-positive acute coronary syndrome, the combination of guideline-directed medical therapy with routine revascularization is associated with improved outcomes. However, the role of routine revascularization in stable ischemic heart disease, in addition to medical therapy, remains a matter of debate. Read More

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http://link.springer.com/10.1007/s11936-019-0720-9
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http://dx.doi.org/10.1007/s11936-019-0720-9DOI Listing
March 2019
3 Reads

Atherectomy and Specialty Balloons in Percutaneous Coronary Intervention.

Curr Treat Options Cardiovasc Med 2019 Mar 4;21(3):13. Epub 2019 Mar 4.

Cardiac Catheterization Laboratory, Piedmont Heart Institute, 95 Collier Road, Suite 2065, Atlanta, Georgia, 30309, USA.

Purpose Of Review: Interventional cardiologists are increasingly being called upon to perform complex revascularization in patients who are deemed not to be candidates for surgical revascularization and, until recently, many of these patients would have only been offered medical management. Further, changing demographics have resulted in an increasingly elderly and frail population with diabetes and chronic kidney disease being referred for revascularization. Owing to the increasing prevalence of coronary artery calcification and the importance of achieving complete revascularization, advanced tools and techniques are required to safely revascularize this patient population. Read More

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http://dx.doi.org/10.1007/s11936-019-0717-4DOI Listing

Management of Saphenous Vein Graft Disease in Patients with Prior Coronary Artery Bypass Surgery.

Curr Treat Options Cardiovasc Med 2019 Feb 28;21(2):12. Epub 2019 Feb 28.

Division of Cardiovascular Medicine, Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.

Purpose Of Review: In this review, we summarize the pathogenesis of saphenous venous graft (SVG) failure in patients following coronary artery bypass graft (CABG) surgery. We also provide an update on various aspects of prevention and management of SVG failure.

Recent Findings: Application of perioperative measures and medical therapies to promote SVG patency is crucial to optimize clinical outcomes in patients following CABG. Read More

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http://dx.doi.org/10.1007/s11936-019-0714-7DOI Listing
February 2019
4 Reads

Evaluation and Monitoring of Pulmonary Hypertension in Neonates With Congenital Diaphragmatic Hernia.

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2):11. Epub 2019 Feb 15.

Department of Pediatrics, University of Minnesota, 2450 Riverside Ave, East Building, 5th Floor, Minneapolis, MN, 55454, USA.

Purpose Of Review: This review aims to describe the assessment of pulmonary hypertension and ventricular function in neonates with congenital diaphragmatic hernia and the long-term follow-up of their pulmonary vascular disease.

Recent Findings: In 2015, the pediatric pulmonary hypertension guidelines from the American Heart Association and American Thoracic Society suggested class I level of evidence B guidelines for routine evaluation of patients with congenital diaphragmatic hernia, including longitudinal care in an interdisciplinary pulmonary hypertension program and following the recommendations offered for all children with pulmonary hypertension. Congenital diaphragmatic hernia causes compression of the lungs during critical stages of fetal development and results in lung hypoplasia. Read More

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http://dx.doi.org/10.1007/s11936-019-0711-xDOI Listing
February 2019

Comprehensive Evaluation of Right Heart Performance and Pulmonary Hemodynamics in Neonatal Pulmonary Hypertension : Evaluation of cardiopulmonary performance in neonatal pulmonary hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2):10. Epub 2019 Feb 15.

Section of Neonatology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Purpose Of Review: Pulmonary hypertension is characterized by an elevation of pulmonary artery pressures and prolonged exposure of the right ventricle to high afterload that collectively contribute to morbidity and mortality in both the term and preterm infants. This review summarizes the pathogenesis, etiologies, and hemodynamic profiles of the conditions that result in pulmonary hypertension in neonates. We explore the application of echocardiographic techniques for the assessment of right ventricular performance and pulmonary hemodynamics that enhance and guide the diagnosis and management strategies in neonates. Read More

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http://dx.doi.org/10.1007/s11936-019-0713-8DOI Listing
February 2019

Prelude to "Pediatric and Congenital Heart Disease".

Authors:
Gautam K Singh

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2). Epub 2019 Feb 15.

School of Medicine, Washington University in St. Louis, Box 8116-NWT One Children's Place, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11936-019-0716-5DOI Listing
February 2019

Preterm Birth Is a Novel, Independent Risk Factor for Altered Cardiac Remodeling and Early Heart Failure: Is it Time for a New Cardiomyopathy?

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Level 1, John Radcliffe Hospital, Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

Purpose Of Review: Around 10% of the global population is born preterm (< 37 weeks' gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies. Read More

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http://dx.doi.org/10.1007/s11936-019-0712-9DOI Listing
February 2019

Renal Artery Denervation for Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

Purpose Of Review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Read More

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http://dx.doi.org/10.1007/s11936-019-0715-6DOI Listing
February 2019

Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 9;21(1). Epub 2019 Feb 9.

Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO, 80045, USA.

Purpose Of Review: The purpose of this review is to detail the advanced echocardiographic studies that evaluated outcomes in pediatric PH using these advanced imaging techniques: (1) right heart size and function (using 2D and 3D echocardiography), (2) myocardial mechanics, and (3) right ventricular (RV) to pulmonary arterial coupling.

Recent Findings: Advanced echocardiographic imaging tools in pediatric PH include RV/left ventricular ratio, 3D echocardiographic assessment of RV volumes and ejection fraction, right atrial and RV strain, and RV-pulmonary arterial coupling ratio that allow for evaluation of clinical outcomes in this patient population. The right atrial to RV axis provides insights to RV diastolic function that has been poorly understood in pediatrics. Read More

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http://dx.doi.org/10.1007/s11936-019-0710-yDOI Listing
February 2019
1 Read

Coronary Revascularization in High-Risk Stable Patients With Significant Comorbidities: Challenges in Decision-Making.

Curr Treat Options Cardiovasc Med 2019 Feb 9;21(1). Epub 2019 Feb 9.

Division of Cardiology, Albany Medical Center, 47 New Scotland Ave, Albany, NY, 12208, USA.

Purpose Of Review: There is a growing cohort of complex high-risk patients with stable ischemic heart disease (SIHD) who present for coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). These patients are older, have complex coronary disease, and a substantial comorbidity burden including frailty. The procedural risks and outcomes of CABG and PCI in these patients are more difficult to assess based on the available literature, which has generally studied a younger population with a lower comorbidity burden. Read More

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http://dx.doi.org/10.1007/s11936-019-0706-7DOI Listing
February 2019

Revascularization in Cardiogenic Shock and Advanced Heart Failure.

Curr Treat Options Cardiovasc Med 2019 Feb 7;21(1). Epub 2019 Feb 7.

The Cardiovascular Center, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose Of Review: Ischemic heart disease is the most common cause of heart failure with systolic dysfunction. The progressive course of heart failure characterized by increasing levels of care and worsening quality of life often indicates an advanced stage. Similarly, cardiogenic shock remains a major clinical problem with prohibitively high mortality rates despite major advances in clinical care. Read More

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http://dx.doi.org/10.1007/s11936-019-0708-5DOI Listing
February 2019
5 Reads

Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.

Curr Treat Options Cardiovasc Med 2019 Feb 7;21(1). Epub 2019 Feb 7.

The Cardiovascular Center, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose Of Review: The choice of appropriate antithrombotic therapy in patients with atrial fibrillation (AF) undergoing percutaneous coronary interventions (PCI) should be approached prudently. Careful consideration is necessary, balancing the ischemic and bleeding risk. Traditionally, triple antithrombotic therapy comprising of aspirin, a P2Y12 inhibitor, and an oral anticoagulant is associated with high bleeding rates. Read More

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http://dx.doi.org/10.1007/s11936-019-0705-8DOI Listing
February 2019

Radial Percutaneous Coronary Intervention in Complex Arm and Chest Vasculature: Tips and Tricks.

Curr Treat Options Cardiovasc Med 2019 Jan 26;21(1). Epub 2019 Jan 26.

University of Illinois - Chicago, 840 S Wood St, MC 715, Chicago, IL, 60607, USA.

Purpose Of Review: The purpose of this review is to identify the anatomical difficulties an operator may encounter during the transradial approach for cardiac catheterization and to offer tips and tricks to overcome those challenges.

Recent Findings: With increasing implementation of the transradial approach for cardiac catheterization, many new techniques have been utilized to overcome anatomical challenges. This article also discusses the difficulties faced during transradial approach in patients with prior coronary artery bypass grafting (CABG). Read More

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http://dx.doi.org/10.1007/s11936-019-0707-6DOI Listing
January 2019
1 Read

Contemporary Approach to Chronic Total Occlusion Interventions.

Curr Treat Options Cardiovasc Med 2019 Jan 18;21(1). Epub 2019 Jan 18.

Minneapolis Heart Institute at Abbott Northwestern Hospital, 920 E 28th Street, Suite 300, Minneapolis, MN, 55407, USA.

Purpose Of Review: Chronic total occlusion (CTO) poses one of the greatest technical challenges to interventional cardiologists. Despite recent advancements in techniques and clinical trials showing significant benefits of CTO percutaneous coronary interventions (PCI), the proportion of patients with untreated CTOs remains high. We therefore aim to perform a comprehensive review of the various techniques available, recent advancements, benefits, and complications associated with CTO PCI. Read More

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http://link.springer.com/10.1007/s11936-019-0704-9
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http://dx.doi.org/10.1007/s11936-019-0704-9DOI Listing
January 2019
7 Reads

Interpreting the Athlete's ECG: Current State and Future Perspectives.

Curr Treat Options Cardiovasc Med 2018 Nov 19;20(12):104. Epub 2018 Nov 19.

Cardiology Clinical and Academic Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

Sudden cardiac death (SCD) is the leading cause of death in athletes. A large proportion of these deaths are associated with undiagnosed cardiovascular disease. Screening for high-risk individuals enables early detection of pathology, as well as permitting lifestyle modification or therapeutic intervention. Read More

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http://dx.doi.org/10.1007/s11936-018-0693-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244896PMC
November 2018
26 Reads

Vascular Genetics: Presentations, Testing, and Prognostics.

Curr Treat Options Cardiovasc Med 2018 Nov 13;20(12):103. Epub 2018 Nov 13.

Adult Congenital and Cardiovascular Genetics Center, Division of Cardiovascular Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose Of Review: Numerous studies have begun to unravel the genetic basis of not only aortic disease but also other forms of commonly encountered vascular diseases. The goal of this review is to provide clinicians a reference to help identify and diagnose different types of vascular disease with a genetic underpinning.

Recent Findings: Ongoing studies have identified numerous genes involved in the TGF-β signaling pathway that are also associated with thoracic aortic aneurysm and dissection, and it is possible to test for pathogenic variants in these genes in the clinical setting using commercially available genetic testing panels. Read More

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http://link.springer.com/10.1007/s11936-018-0703-2
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http://dx.doi.org/10.1007/s11936-018-0703-2DOI Listing
November 2018
13 Reads

State of the Art Management of Mechanical Heart Valves During Pregnancy.

Curr Treat Options Cardiovasc Med 2018 Nov 12;20(12):102. Epub 2018 Nov 12.

Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, BCH 3215, Boston, MA, 02115, USA.

Purpose Of The Review: To review the management of women with mechanical heart valves during pregnancy, from preconception counseling through delivery with a summary of the latest guidelines.

Recent Findings: The hypercoagulability of pregnancy combined with the imperfect choices of anticoagulant agents contribute to a high risk of complications in pregnant women with mechanical heart valves. Valve thrombosis remains a major concern, much of which occurs during the first trimester transition to heparin-based products. Read More

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http://dx.doi.org/10.1007/s11936-018-0702-3DOI Listing
November 2018
2 Reads

The Female Athlete's Heart: Facts and Fallacies.

Curr Treat Options Cardiovasc Med 2018 Nov 3;20(12):101. Epub 2018 Nov 3.

Cardiology Clinical Academic Group, St George's University of London, Cranmer Terrace, SW 17 0RE, London, UK.

Purpose Of The Review: For many years, competitive sport has been dominated by men. Recent times have witnessed a significant increase in women participating in elite sports. As most studies investigated male athletes, with few reports on female counterparts, it is crucial to have a better understanding on physiological cardiac adaptation to exercise in female athletes, to distinguish normal phenotypes from potentially fatal cardiac diseases. Read More

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http://dx.doi.org/10.1007/s11936-018-0699-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223714PMC
November 2018
11 Reads

Left Ventricular Hypertrophy in Athletes: Differentiating Physiology From Pathology.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):96. Epub 2018 Oct 26.

Cardiology Clinical Academic Group, St George's, University of London, London, UK.

Purpose Of Review: The changes that occur in athlete's heart are influenced by a number of factors including age, gender, ethnicity and the type of cardiovascular training. It is therefore important that the clinician is able to integrate all of these factors when assessing athletes to be able to guide investigations appropriately and to distinguish pathology from physiology. This review discusses the potential diagnostic conundrums when trying to differentiate physiological left ventricular hypertrophy from pathological hypertrophic cardiomyopathy in athletes. Read More

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http://link.springer.com/10.1007/s11936-018-0691-2
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http://dx.doi.org/10.1007/s11936-018-0691-2DOI Listing
October 2018
9 Reads

Visceral Artery Aneurysms: Diagnosis, Surveillance, and Treatment.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):97. Epub 2018 Oct 26.

Zucker School of Medicine at Hofstra Northwell, Northshore University Hospital, 300 Community Drive, Manhasset, NY, 11030, USA.

Visceral artery aneurysms (VAAs) are a rare, but serious clinical entity as rupture confers a high rate of mortality. Data regarding the prevalence, treatment, and prognosis of VAAs is largely from case series, as true randomized trials are lacking. The incidence of VAAs has risen over the decades with advances in imaging technology, availability, and utilization. Read More

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http://link.springer.com/10.1007/s11936-018-0696-x
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http://dx.doi.org/10.1007/s11936-018-0696-xDOI Listing
October 2018
17 Reads

Left Ventricular Trabeculations in Athletes: Epiphenomenon or Phenotype of Disease?

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):100. Epub 2018 Oct 26.

Cardiology Clinical Academic Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

Purpose Of Review: Excessive trabeculation attracting a diagnosis of left ventricular noncompaction cardiomyopathy (LVNC) has been reported in ostensibly healthy athletes. This review aims to explain why this occurs and whether this represents a spectrum of athletic physiological remodelling or unmasking of occult cardiomyopathy.

Recent Findings: Genetic studies have yet to identify a dominant mutation associated with the LVNC phenotype and reported gene mutations overlap with many distinct cardiomyopathies and ion channel disorders, implying that the phenotype is shared across different genetic conditions. Read More

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http://link.springer.com/10.1007/s11936-018-0698-8
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http://dx.doi.org/10.1007/s11936-018-0698-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209014PMC
October 2018
12 Reads

Transcatheter Mitral Valve Planning and the Neo-LVOT: Utilization of Virtual Simulation Models and 3D Printing.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):99. Epub 2018 Oct 26.

St. Paul's Hospital & University of British Columbia, Vancouver, Canada.

Purpose Of Review: Transcatheter mitral valve replacement (TMVR) is an emerging alternative for patients with severe mitral valve regurgitation who are considered at high risk for conventional surgical options. The early clinical experience with TMVR has shown that pre-procedural planning with computed tomography (CT) is needed to mitigate the risk of potentially lethal procedural complications such as left ventricular outflow tract (LVOT) obstruction. The goal of this review is to provide an overview of key concepts relating to TMVR pre-procedural planning, with particular emphasis on imaging-based methods for predicting TMVR-related LVOT obstruction. Read More

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http://link.springer.com/10.1007/s11936-018-0694-z
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http://dx.doi.org/10.1007/s11936-018-0694-zDOI Listing
October 2018
24 Reads

Atrial Fibrillation (AF) in Endurance Athletes: a Complicated Affair.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):98. Epub 2018 Oct 26.

MSc Sports Cardiology, Cardiology Clinical Academic Group, St George's, University of London, London, UK.

Purpose Of Review: A complex relationship exists between exercise and atrial fibrillation (AF). Moderate exercise reduces AF risk whereas intense strenuous exercise has been shown to increase AF burden. It remains unclear at which point exercise may become detrimental. Read More

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http://link.springer.com/10.1007/s11936-018-0697-9
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http://dx.doi.org/10.1007/s11936-018-0697-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209018PMC
October 2018
19 Reads

Manufacturing Better Outcomes in Cardiovascular Intervention: 3D Printing in Clinical Practice Today.

Curr Treat Options Cardiovasc Med 2018 Oct 25;20(12):95. Epub 2018 Oct 25.

Department of Radiology, Weill Cornell Medicine, New York City, USA.

Purpose Of Review: Describe and evaluate the integration of 3D printing-related innovations into current cardiovascular treatment paradigms and examine the state of regulatory and reimbursement hurdles ahead.

Recent Findings: Mounting years of clinical experience have established the utility of printed models of patient anatomy in numerous treatment and teaching scenarios, most notably as pre- and intra-procedural planning tools guiding decision-making for congenital heart disease and catheter-based interventions. In part due to a continued lack of reimbursement and under-defined (and slow to evolve) regulatory status, these use cases remain largely investigational even as they grow increasingly routine. Read More

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http://dx.doi.org/10.1007/s11936-018-0692-1DOI Listing
October 2018
3 Reads

Incidental Non-cardiac Findings in Cardiovascular Imaging.

Curr Treat Options Cardiovasc Med 2018 Oct 23;20(12):93. Epub 2018 Oct 23.

University of Edinburgh/BHF Centre for Cardiovascular Science, Chancellor's Building, SU305, 49 Little France Crescent, Edinburgh, EH16SUF, UK.

Improvements in imaging techniques have led to an expansion in the number of cross-sectional cardiac studies being performed. This means that incidental non-cardiac findings (INCF) identified on cardiac imaging have become an important clinical concern. The majority of INCF are not clinically significant. Read More

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http://link.springer.com/10.1007/s11936-018-0700-5
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http://dx.doi.org/10.1007/s11936-018-0700-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209026PMC
October 2018
20 Reads

Intracranial Aneurysm: Diagnostic Monitoring, Current Interventional Practices, and Advances.

Curr Treat Options Cardiovasc Med 2018 Oct 24;20(12):94. Epub 2018 Oct 24.

Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, 130 E 77th Street, 3rd Floor, New York, NY, 10075, USA.

Purpose Of Review: Cerebral aneurysms are commonly diagnosed incidentally with non-invasive neuro-imaging modalities (i.e., brain MRA and/or head CTA). Read More

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http://link.springer.com/10.1007/s11936-018-0695-y
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http://dx.doi.org/10.1007/s11936-018-0695-yDOI Listing
October 2018
23 Reads

Correction to: Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines.

Curr Treat Options Cardiovasc Med 2018 Oct 18;20(11):92. Epub 2018 Oct 18.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins Medical Institutions, Blalock 524D1, 600 N Wolfe St, Baltimore, MD, 21287, USA.

In the recently published review "Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines," the following author name was inadvertently misspelled as Alison Peng. The correct spelling of the author's name is: Allison Peng as shown above. Read More

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http://link.springer.com/10.1007/s11936-018-0701-4
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http://dx.doi.org/10.1007/s11936-018-0701-4DOI Listing
October 2018
6 Reads

Peripartum Cardiomyopathy: a Review for the Clinician.

Curr Treat Options Cardiovasc Med 2018 Sep 29;20(11):91. Epub 2018 Sep 29.

Knight Cardiovascular Institute, Oregon Health and Sciences University, 3181 Sam Jackson Park Road, UHN 62, Portland, OR, 97239, USA.

Purpose Of Review: This review summarizes the pathophysiology, diagnosis, and treatment of peripartum cardiomyopathy (PPCM), with a focus on recent discoveries of clinical relevance.

Recent Findings: An increase in oxidative stress and anti-angiogenic activity play key roles in the pathophysiology of peripartum cardiomyopathy. Therapies that target this dysregulation may have a future role in treatment. Read More

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http://dx.doi.org/10.1007/s11936-018-0690-3DOI Listing
September 2018
21 Reads

Imaging and Management of Heart Failure and Preserved Ejection Fraction.

Curr Treat Options Cardiovasc Med 2018 Sep 27;20(11):90. Epub 2018 Sep 27.

Cardiovascular Imaging Research Group, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria, 3004, Australia.

Purpose Of Review: The prevalence of heart failure with preserved ejection fraction (HFpEF) is rising and in some places, it is already the most prevalent form of heart failure. The usual treatments of HF do not improve mortality or outcomes in HFpEF, suggesting a distinct pathophysiology that remains poorly characterized. The neutrality of clinical trial results is also attributable to the heterogeneity of patient profiles, and by poor characterization offered by classical echocardiography parameters. Read More

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http://link.springer.com/10.1007/s11936-018-0689-9
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http://dx.doi.org/10.1007/s11936-018-0689-9DOI Listing
September 2018
30 Reads

Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines.

Curr Treat Options Cardiovasc Med 2018 Sep 26;20(11):89. Epub 2018 Sep 26.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins Medical Institutions, Blalock 524D1, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose Of Review: In this review, we evaluate the coronary artery calcium (CAC) score as a biomarker for advanced atherosclerotic cardiovascular disease (ASCVD) risk assessment.

Recent Findings: We summarize the evidence from multiple epidemiological studies, which show a clear advantage of CAC compared to traditional and non-traditional cardiovascular risk factors. We then compare the recommendations included in the 2013 American College of Cardiology/American Heart Association (ACC/AHA) and in the 2017 Society of Cardiovascular Computed Tomography (SCCT) guidelines for the use of CAC in ASCVD risk assessment, and examine the recent 2018 US Preventive Services Task Force (USPSTF) document. Read More

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http://dx.doi.org/10.1007/s11936-018-0685-0DOI Listing
September 2018
2 Reads

Disparities in Cardiac Care of Women: Current Data and Possible Solutions.

Curr Treat Options Cardiovasc Med 2018 Sep 21;20(11):87. Epub 2018 Sep 21.

Department of Cardiovascular Disease, 200 1st street SW, Rochester, MN, 55901, USA.

Purpose Of Review: Cardiovascular disease remains the leading cause of death in women. The goal of this review is to address known disparities in cardiovascular care with regard to diagnosis and treatment of heart disease in women.

Recent Findings: Gender-specific differences in regard to the incidence, treatment, and outcomes of common cardiovascular pathology are increasingly recognized. Read More

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http://dx.doi.org/10.1007/s11936-018-0688-xDOI Listing
September 2018
11 Reads

Sex Differences in the Management of Advanced Heart Failure.

Curr Treat Options Cardiovasc Med 2018 Sep 21;20(11):88. Epub 2018 Sep 21.

Massachusetts General Hospital, 55 Fruit Street GRB-800, Boston, MA, 02114, USA.

Purpose Of Review: Heart failure (HF) is prevalent among women and remains a leading cause of morbidity and mortality in the United States. Currently, 3 million women live with HF and the prevalence is projected to continue to increase. The purpose of this review is to highlight sex differences in the use and response to evidence-based pharmacological, device, and advanced HF therapies, as well as explore emerging areas of research in sex differences in the treatment of HF. Read More

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http://dx.doi.org/10.1007/s11936-018-0687-yDOI Listing
September 2018
1 Read

The Role of Cardiovascular Magnetic Resonance in Sports Cardiology; Current Utility and Future Perspectives.

Curr Treat Options Cardiovasc Med 2018 Aug 31;20(10):86. Epub 2018 Aug 31.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK.

Purpose Of Review: Cardiovascular magnetic resonance (CMR) is frequently used in the investigation of suspected cardiac disease in athletes. In this review, we discuss how CMR can be used in athletes with suspected cardiomyopathy with particular reference to volumetric analysis and tissue characterization. We also discuss the finding of non-ischaemic fibrosis in athletes describing its prevalence, distribution and clinical importance. Read More

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http://link.springer.com/10.1007/s11936-018-0679-y
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http://dx.doi.org/10.1007/s11936-018-0679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132733PMC
August 2018
11 Reads

The "Extreme Exercise Hypothesis": Recent Findings and Cardiovascular Health Implications.

Curr Treat Options Cardiovasc Med 2018 Aug 28;20(10):84. Epub 2018 Aug 28.

Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, MI, USA.

Purpose Of Review: The "Extreme Exercise Hypothesis" is characterized by a U-shaped or reverse J-shaped, dose-response curve between physical activity volumes and cardiovascular health outcomes. In this review, we summarize recent findings that may support or refute the "Extreme Exercise Hypothesis." Furthermore, we discuss potential cardiovascular health implications of the cardiac anatomical, structural, contractility, and biomarker abnormalities that have been reported in some veteran endurance athletes. Read More

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http://dx.doi.org/10.1007/s11936-018-0674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132728PMC
August 2018
18 Reads

Cardiac Screening of Young Athletes: a Practical Approach to Sudden Cardiac Death Prevention.

Curr Treat Options Cardiovasc Med 2018 Aug 28;20(10):85. Epub 2018 Aug 28.

Cardiovascular Sciences Research Centre, St George's University of London, London, UK.

Purpose Of Review: We aim to report on the current status of cardiovascular screening of athletes worldwide and review the up-to-date evidence for its efficacy in reducing sudden cardiac death in young athletes.

Recent Findings: A large proportion of sudden cardiac death in young individuals and athletes occurs during rest with sudden arrhythmic death syndrome being recognised as the leading cause. The international recommendations for ECG interpretation have reduced the false-positive ECG rate to 3% and reduced the cost of screening by 25% without compromising the sensitivity to identify serious disease. Read More

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http://dx.doi.org/10.1007/s11936-018-0681-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132782PMC
August 2018
1 Read

Sex Differences in Atrial Fibrillation-Update on Risk Assessment, Treatment, and Long-Term Risk.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):79. Epub 2018 Aug 27.

Rush Heart Center for Women, 1725 W. Harrison St. Suite 1159, Chicago, IL, 60612-3864, USA.

Purpose Of Review: Atrial fibrillation (AF) is a growing health problem worldwide. While the disease plagues both men and women, this arrhythmia does not affect both sexes equally. Women are more likely to have major adverse outcomes such as stroke and its sequela; however, recent data on stroke prevention show improving outcomes. Read More

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http://dx.doi.org/10.1007/s11936-018-0682-3DOI Listing
August 2018
2 Reads

Assessment of the QT Interval in Athletes: Red Flags and Pitfalls.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):82. Epub 2018 Aug 27.

MQ Health Cardiology, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia.

Purpose Of Review: Pre-participation athlete screening has led to the referral of asymptomatic athletes with a prolonged QT interval warranting their evaluation for long QT syndrome (LQTS). Establishing a diagnosis of LQTS can be difficult, particularly in asymptomatic athletes presenting with a prolonged QTc < 500 ms. This review examines the evaluatory pathway to ascertain the common pitfalls leading to mis- or overdiagnosis. Read More

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http://dx.doi.org/10.1007/s11936-018-0678-zDOI Listing
August 2018
1 Read

The Global Burden of Cardiovascular Disease in Women.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):81. Epub 2018 Aug 27.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Blake 256, Boston, MA, 02114-2696, USA.

Purpose Of Review: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for one third of all deaths in 2015. Alarmingly, there has been slowing of the decline in age-standardized CVD mortality over the last 5 years compared to the previous 25 years.

Recent Findings: Given the increasing global CVD burden, in 2011, the United Nations declared the goal to reduce premature mortality from the four main non-communicable diseases by 25% from 2010 to 2025, abbreviated as the 25 × 25 goal. Read More

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http://dx.doi.org/10.1007/s11936-018-0676-1DOI Listing
August 2018
3 Reads

Speckle Tracking Echocardiography for the Assessment of the Athlete's Heart: Is It Ready for Daily Practice?

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):83. Epub 2018 Aug 27.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Liverpool, L3 3AF, UK.

Purpose Of Review: To describe the use of speckle tracking echocardiography (STE) in the biventricular assessment of athletes' heart (AH). Can STE aid differential diagnosis during pre-participation cardiac screening (PCS) of athletes?

Recent Findings: Data from recent patient, population and athlete studies suggest potential discriminatory value of STE, alongside standard echocardiographic measurements, in the early detection of clinically relevant systolic dysfunction. STE can also contribute to subsequent prognosis and risk stratification. Read More

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http://dx.doi.org/10.1007/s11936-018-0677-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132779PMC
August 2018
2 Reads

Imaging of the Postsurgical Aorta in Marfan Syndrome.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):80. Epub 2018 Aug 27.

Department of Radiology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Box 141, New York, NY, 10065, USA.

Marfan syndrome is a heritable multisystem connective tissue disease and is the most common genetic cause of aortic disease. Guidelines for surgical repair and recommendations for surveillance imaging aim to prevent aneurysm rupture, aortic dissection, and death. Options for proximal aorta repair include the modified Bentall procedure and valve-sparing aortic root repairs. Read More

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http://dx.doi.org/10.1007/s11936-018-0675-2DOI Listing
August 2018
13 Reads

Cardiac Rehabilitation and Exercise Prescription in Symptomatic Patients with Non-Obstructive Coronary Artery Disease-a Systematic Review.

Curr Treat Options Cardiovasc Med 2018 Aug 18;20(9):78. Epub 2018 Aug 18.

Emergency, Cardiovascular and Critical Care Research Group, Faculty of Health, Social Care and Education (Joint Faculty), Kingston University & St George's University of London, London, UK.

Purpose Of Review: Non-obstructive coronary artery disease (NOCAD) on coronary angiography is a common finding in patients with stable angina. Angina in NOCAD patients is thought to be caused by endothelial dysfunction of the epicardial coronary arteries and/or the microvasculature. Treatment is empiric, and 30% of patients remain symptomatic in spite of therapy. Read More

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http://dx.doi.org/10.1007/s11936-018-0667-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105244PMC
August 2018
16 Reads

Multi-Modality Imaging in the Evaluation and Treatment of Tricuspid Regurgitation.

Curr Treat Options Cardiovasc Med 2018 Aug 9;20(9):77. Epub 2018 Aug 9.

Division of Cardiology, Department of Medicine, NewYork Presbyterian Hospital-Weill Cornell Medicine, 520 E 70th St, Starr 4, New York, NY, 10021, USA.

Purpose Of Review: The goal of this review is to cover the epidemiology of tricuspid regurgitation (TR), anatomy of the tricuspid valve (TV), and the mechanisms and modern treatment of TR. The focus will be on the role of echocardiography, cardiac CT, and MRI to determine the mechanism, severity, and management strategies of TR.

Recent Findings: The evaluation and management of TR is a rapidly growing field with significant advances in both imaging and interventions. Read More

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http://dx.doi.org/10.1007/s11936-018-0672-5DOI Listing
August 2018
8 Reads

Specialized Care for Women: the Impact of Women's Heart Centers.

Curr Treat Options Cardiovasc Med 2018 Aug 8;20(9):76. Epub 2018 Aug 8.

Rush Heart Center for Women, Rush University Medical Center, Chicago, IL, USA.

Purpose Of The Review: Cardiovascular disease (CVD) has been and remains the leading cause of mortality in women in the United States. For decades, more women died every year of CVD compared to men. Heart centers for women (HCW) are developed in response to the need for greater patient and physician awareness of CVD in women and to conduct sex-specific research in women. Read More

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http://dx.doi.org/10.1007/s11936-018-0656-5DOI Listing
August 2018
15 Reads