1,213 results match your criteria Current Treatment Options in Cardiovascular Medicine[Journal]


Evaluation and Monitoring of Pulmonary Hypertension in Neonates With Congenital Diaphragmatic Hernia.

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2):11. Epub 2019 Feb 15.

Department of Pediatrics, University of Minnesota, 2450 Riverside Ave, East Building, 5th Floor, Minneapolis, MN, 55454, USA.

Purpose Of Review: This review aims to describe the assessment of pulmonary hypertension and ventricular function in neonates with congenital diaphragmatic hernia and the long-term follow-up of their pulmonary vascular disease.

Recent Findings: In 2015, the pediatric pulmonary hypertension guidelines from the American Heart Association and American Thoracic Society suggested class I level of evidence B guidelines for routine evaluation of patients with congenital diaphragmatic hernia, including longitudinal care in an interdisciplinary pulmonary hypertension program and following the recommendations offered for all children with pulmonary hypertension. Congenital diaphragmatic hernia causes compression of the lungs during critical stages of fetal development and results in lung hypoplasia. Read More

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http://dx.doi.org/10.1007/s11936-019-0711-xDOI Listing
February 2019

Comprehensive Evaluation of Right Heart Performance and Pulmonary Hemodynamics in Neonatal Pulmonary Hypertension : Evaluation of cardiopulmonary performance in neonatal pulmonary hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2):10. Epub 2019 Feb 15.

Section of Neonatology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Purpose Of Review: Pulmonary hypertension is characterized by an elevation of pulmonary artery pressures and prolonged exposure of the right ventricle to high afterload that collectively contribute to morbidity and mortality in both the term and preterm infants. This review summarizes the pathogenesis, etiologies, and hemodynamic profiles of the conditions that result in pulmonary hypertension in neonates. We explore the application of echocardiographic techniques for the assessment of right ventricular performance and pulmonary hemodynamics that enhance and guide the diagnosis and management strategies in neonates. Read More

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http://dx.doi.org/10.1007/s11936-019-0713-8DOI Listing
February 2019

Prelude to "Pediatric and Congenital Heart Disease".

Authors:
Gautam K Singh

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2). Epub 2019 Feb 15.

School of Medicine, Washington University in St. Louis, Box 8116-NWT One Children's Place, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11936-019-0716-5DOI Listing
February 2019

Preterm Birth Is a Novel, Independent Risk Factor for Altered Cardiac Remodeling and Early Heart Failure: Is it Time for a New Cardiomyopathy?

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Level 1, John Radcliffe Hospital, Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

Purpose Of Review: Around 10% of the global population is born preterm (< 37 weeks' gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies. Read More

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http://dx.doi.org/10.1007/s11936-019-0712-9DOI Listing
February 2019

Renal Artery Denervation for Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

Purpose Of Review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Read More

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http://dx.doi.org/10.1007/s11936-019-0715-6DOI Listing
February 2019

Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 9;21(1). Epub 2019 Feb 9.

Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO, 80045, USA.

Purpose Of Review: The purpose of this review is to detail the advanced echocardiographic studies that evaluated outcomes in pediatric PH using these advanced imaging techniques: (1) right heart size and function (using 2D and 3D echocardiography), (2) myocardial mechanics, and (3) right ventricular (RV) to pulmonary arterial coupling.

Recent Findings: Advanced echocardiographic imaging tools in pediatric PH include RV/left ventricular ratio, 3D echocardiographic assessment of RV volumes and ejection fraction, right atrial and RV strain, and RV-pulmonary arterial coupling ratio that allow for evaluation of clinical outcomes in this patient population. The right atrial to RV axis provides insights to RV diastolic function that has been poorly understood in pediatrics. Read More

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http://dx.doi.org/10.1007/s11936-019-0710-yDOI Listing
February 2019

Coronary Revascularization in High-Risk Stable Patients With Significant Comorbidities: Challenges in Decision-Making.

Curr Treat Options Cardiovasc Med 2019 Feb 9;21(1). Epub 2019 Feb 9.

Division of Cardiology, Albany Medical Center, 47 New Scotland Ave, Albany, NY, 12208, USA.

Purpose Of Review: There is a growing cohort of complex high-risk patients with stable ischemic heart disease (SIHD) who present for coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). These patients are older, have complex coronary disease, and a substantial comorbidity burden including frailty. The procedural risks and outcomes of CABG and PCI in these patients are more difficult to assess based on the available literature, which has generally studied a younger population with a lower comorbidity burden. Read More

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http://dx.doi.org/10.1007/s11936-019-0706-7DOI Listing
February 2019

Revascularization in Cardiogenic Shock and Advanced Heart Failure.

Curr Treat Options Cardiovasc Med 2019 Feb 7;21(1). Epub 2019 Feb 7.

The Cardiovascular Center, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose Of Review: Ischemic heart disease is the most common cause of heart failure with systolic dysfunction. The progressive course of heart failure characterized by increasing levels of care and worsening quality of life often indicates an advanced stage. Similarly, cardiogenic shock remains a major clinical problem with prohibitively high mortality rates despite major advances in clinical care. Read More

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http://dx.doi.org/10.1007/s11936-019-0708-5DOI Listing
February 2019
1 Read

Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.

Curr Treat Options Cardiovasc Med 2019 Feb 7;21(1). Epub 2019 Feb 7.

The Cardiovascular Center, Tufts Medical Center, Boston, MA, 02111, USA.

Purpose Of Review: The choice of appropriate antithrombotic therapy in patients with atrial fibrillation (AF) undergoing percutaneous coronary interventions (PCI) should be approached prudently. Careful consideration is necessary, balancing the ischemic and bleeding risk. Traditionally, triple antithrombotic therapy comprising of aspirin, a P2Y12 inhibitor, and an oral anticoagulant is associated with high bleeding rates. Read More

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http://dx.doi.org/10.1007/s11936-019-0705-8DOI Listing
February 2019

Radial Percutaneous Coronary Intervention in Complex Arm and Chest Vasculature: Tips and Tricks.

Curr Treat Options Cardiovasc Med 2019 Jan 26;21(1). Epub 2019 Jan 26.

University of Illinois - Chicago, 840 S Wood St, MC 715, Chicago, IL, 60607, USA.

Purpose Of Review: The purpose of this review is to identify the anatomical difficulties an operator may encounter during the transradial approach for cardiac catheterization and to offer tips and tricks to overcome those challenges.

Recent Findings: With increasing implementation of the transradial approach for cardiac catheterization, many new techniques have been utilized to overcome anatomical challenges. This article also discusses the difficulties faced during transradial approach in patients with prior coronary artery bypass grafting (CABG). Read More

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http://dx.doi.org/10.1007/s11936-019-0707-6DOI Listing
January 2019
1 Read

Contemporary Approach to Chronic Total Occlusion Interventions.

Curr Treat Options Cardiovasc Med 2019 Jan 18;21(1). Epub 2019 Jan 18.

Minneapolis Heart Institute at Abbott Northwestern Hospital, 920 E 28th Street, Suite 300, Minneapolis, MN, 55407, USA.

Purpose Of Review: Chronic total occlusion (CTO) poses one of the greatest technical challenges to interventional cardiologists. Despite recent advancements in techniques and clinical trials showing significant benefits of CTO percutaneous coronary interventions (PCI), the proportion of patients with untreated CTOs remains high. We therefore aim to perform a comprehensive review of the various techniques available, recent advancements, benefits, and complications associated with CTO PCI. Read More

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http://link.springer.com/10.1007/s11936-019-0704-9
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http://dx.doi.org/10.1007/s11936-019-0704-9DOI Listing
January 2019
4 Reads

Interpreting the Athlete's ECG: Current State and Future Perspectives.

Curr Treat Options Cardiovasc Med 2018 Nov 19;20(12):104. Epub 2018 Nov 19.

Cardiology Clinical and Academic Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

Sudden cardiac death (SCD) is the leading cause of death in athletes. A large proportion of these deaths are associated with undiagnosed cardiovascular disease. Screening for high-risk individuals enables early detection of pathology, as well as permitting lifestyle modification or therapeutic intervention. Read More

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http://dx.doi.org/10.1007/s11936-018-0693-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244896PMC
November 2018
17 Reads

Vascular Genetics: Presentations, Testing, and Prognostics.

Curr Treat Options Cardiovasc Med 2018 Nov 13;20(12):103. Epub 2018 Nov 13.

Adult Congenital and Cardiovascular Genetics Center, Division of Cardiovascular Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose Of Review: Numerous studies have begun to unravel the genetic basis of not only aortic disease but also other forms of commonly encountered vascular diseases. The goal of this review is to provide clinicians a reference to help identify and diagnose different types of vascular disease with a genetic underpinning.

Recent Findings: Ongoing studies have identified numerous genes involved in the TGF-β signaling pathway that are also associated with thoracic aortic aneurysm and dissection, and it is possible to test for pathogenic variants in these genes in the clinical setting using commercially available genetic testing panels. Read More

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http://link.springer.com/10.1007/s11936-018-0703-2
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http://dx.doi.org/10.1007/s11936-018-0703-2DOI Listing
November 2018
9 Reads

State of the Art Management of Mechanical Heart Valves During Pregnancy.

Curr Treat Options Cardiovasc Med 2018 Nov 12;20(12):102. Epub 2018 Nov 12.

Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, BCH 3215, Boston, MA, 02115, USA.

Purpose Of The Review: To review the management of women with mechanical heart valves during pregnancy, from preconception counseling through delivery with a summary of the latest guidelines.

Recent Findings: The hypercoagulability of pregnancy combined with the imperfect choices of anticoagulant agents contribute to a high risk of complications in pregnant women with mechanical heart valves. Valve thrombosis remains a major concern, much of which occurs during the first trimester transition to heparin-based products. Read More

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http://dx.doi.org/10.1007/s11936-018-0702-3DOI Listing
November 2018
2 Reads

The Female Athlete's Heart: Facts and Fallacies.

Curr Treat Options Cardiovasc Med 2018 Nov 3;20(12):101. Epub 2018 Nov 3.

Cardiology Clinical Academic Group, St George's University of London, Cranmer Terrace, SW 17 0RE, London, UK.

Purpose Of The Review: For many years, competitive sport has been dominated by men. Recent times have witnessed a significant increase in women participating in elite sports. As most studies investigated male athletes, with few reports on female counterparts, it is crucial to have a better understanding on physiological cardiac adaptation to exercise in female athletes, to distinguish normal phenotypes from potentially fatal cardiac diseases. Read More

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http://dx.doi.org/10.1007/s11936-018-0699-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223714PMC
November 2018
8 Reads

Left Ventricular Hypertrophy in Athletes: Differentiating Physiology From Pathology.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):96. Epub 2018 Oct 26.

Cardiology Clinical Academic Group, St George's, University of London, London, UK.

Purpose Of Review: The changes that occur in athlete's heart are influenced by a number of factors including age, gender, ethnicity and the type of cardiovascular training. It is therefore important that the clinician is able to integrate all of these factors when assessing athletes to be able to guide investigations appropriately and to distinguish pathology from physiology. This review discusses the potential diagnostic conundrums when trying to differentiate physiological left ventricular hypertrophy from pathological hypertrophic cardiomyopathy in athletes. Read More

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http://link.springer.com/10.1007/s11936-018-0691-2
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http://dx.doi.org/10.1007/s11936-018-0691-2DOI Listing
October 2018
9 Reads

Visceral Artery Aneurysms: Diagnosis, Surveillance, and Treatment.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):97. Epub 2018 Oct 26.

Zucker School of Medicine at Hofstra Northwell, Northshore University Hospital, 300 Community Drive, Manhasset, NY, 11030, USA.

Visceral artery aneurysms (VAAs) are a rare, but serious clinical entity as rupture confers a high rate of mortality. Data regarding the prevalence, treatment, and prognosis of VAAs is largely from case series, as true randomized trials are lacking. The incidence of VAAs has risen over the decades with advances in imaging technology, availability, and utilization. Read More

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http://link.springer.com/10.1007/s11936-018-0696-x
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http://dx.doi.org/10.1007/s11936-018-0696-xDOI Listing
October 2018
14 Reads

Left Ventricular Trabeculations in Athletes: Epiphenomenon or Phenotype of Disease?

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):100. Epub 2018 Oct 26.

Cardiology Clinical Academic Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

Purpose Of Review: Excessive trabeculation attracting a diagnosis of left ventricular noncompaction cardiomyopathy (LVNC) has been reported in ostensibly healthy athletes. This review aims to explain why this occurs and whether this represents a spectrum of athletic physiological remodelling or unmasking of occult cardiomyopathy.

Recent Findings: Genetic studies have yet to identify a dominant mutation associated with the LVNC phenotype and reported gene mutations overlap with many distinct cardiomyopathies and ion channel disorders, implying that the phenotype is shared across different genetic conditions. Read More

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http://link.springer.com/10.1007/s11936-018-0698-8
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http://dx.doi.org/10.1007/s11936-018-0698-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209014PMC
October 2018
9 Reads

Transcatheter Mitral Valve Planning and the Neo-LVOT: Utilization of Virtual Simulation Models and 3D Printing.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):99. Epub 2018 Oct 26.

St. Paul's Hospital & University of British Columbia, Vancouver, Canada.

Purpose Of Review: Transcatheter mitral valve replacement (TMVR) is an emerging alternative for patients with severe mitral valve regurgitation who are considered at high risk for conventional surgical options. The early clinical experience with TMVR has shown that pre-procedural planning with computed tomography (CT) is needed to mitigate the risk of potentially lethal procedural complications such as left ventricular outflow tract (LVOT) obstruction. The goal of this review is to provide an overview of key concepts relating to TMVR pre-procedural planning, with particular emphasis on imaging-based methods for predicting TMVR-related LVOT obstruction. Read More

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http://link.springer.com/10.1007/s11936-018-0694-z
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http://dx.doi.org/10.1007/s11936-018-0694-zDOI Listing
October 2018
18 Reads

Atrial Fibrillation (AF) in Endurance Athletes: a Complicated Affair.

Curr Treat Options Cardiovasc Med 2018 Oct 26;20(12):98. Epub 2018 Oct 26.

MSc Sports Cardiology, Cardiology Clinical Academic Group, St George's, University of London, London, UK.

Purpose Of Review: A complex relationship exists between exercise and atrial fibrillation (AF). Moderate exercise reduces AF risk whereas intense strenuous exercise has been shown to increase AF burden. It remains unclear at which point exercise may become detrimental. Read More

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http://link.springer.com/10.1007/s11936-018-0697-9
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http://dx.doi.org/10.1007/s11936-018-0697-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209018PMC
October 2018
9 Reads

Manufacturing Better Outcomes in Cardiovascular Intervention: 3D Printing in Clinical Practice Today.

Curr Treat Options Cardiovasc Med 2018 Oct 25;20(12):95. Epub 2018 Oct 25.

Department of Radiology, Weill Cornell Medicine, New York City, USA.

Purpose Of Review: Describe and evaluate the integration of 3D printing-related innovations into current cardiovascular treatment paradigms and examine the state of regulatory and reimbursement hurdles ahead.

Recent Findings: Mounting years of clinical experience have established the utility of printed models of patient anatomy in numerous treatment and teaching scenarios, most notably as pre- and intra-procedural planning tools guiding decision-making for congenital heart disease and catheter-based interventions. In part due to a continued lack of reimbursement and under-defined (and slow to evolve) regulatory status, these use cases remain largely investigational even as they grow increasingly routine. Read More

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http://dx.doi.org/10.1007/s11936-018-0692-1DOI Listing
October 2018
3 Reads

Incidental Non-cardiac Findings in Cardiovascular Imaging.

Curr Treat Options Cardiovasc Med 2018 Oct 23;20(12):93. Epub 2018 Oct 23.

University of Edinburgh/BHF Centre for Cardiovascular Science, Chancellor's Building, SU305, 49 Little France Crescent, Edinburgh, EH16SUF, UK.

Improvements in imaging techniques have led to an expansion in the number of cross-sectional cardiac studies being performed. This means that incidental non-cardiac findings (INCF) identified on cardiac imaging have become an important clinical concern. The majority of INCF are not clinically significant. Read More

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http://link.springer.com/10.1007/s11936-018-0700-5
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http://dx.doi.org/10.1007/s11936-018-0700-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209026PMC
October 2018
13 Reads

Intracranial Aneurysm: Diagnostic Monitoring, Current Interventional Practices, and Advances.

Curr Treat Options Cardiovasc Med 2018 Oct 24;20(12):94. Epub 2018 Oct 24.

Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, 130 E 77th Street, 3rd Floor, New York, NY, 10075, USA.

Purpose Of Review: Cerebral aneurysms are commonly diagnosed incidentally with non-invasive neuro-imaging modalities (i.e., brain MRA and/or head CTA). Read More

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http://link.springer.com/10.1007/s11936-018-0695-y
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http://dx.doi.org/10.1007/s11936-018-0695-yDOI Listing
October 2018
19 Reads

Correction to: Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines.

Curr Treat Options Cardiovasc Med 2018 Oct 18;20(11):92. Epub 2018 Oct 18.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins Medical Institutions, Blalock 524D1, 600 N Wolfe St, Baltimore, MD, 21287, USA.

In the recently published review "Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines," the following author name was inadvertently misspelled as Alison Peng. The correct spelling of the author's name is: Allison Peng as shown above. Read More

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http://link.springer.com/10.1007/s11936-018-0701-4
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http://dx.doi.org/10.1007/s11936-018-0701-4DOI Listing
October 2018
5 Reads

Peripartum Cardiomyopathy: a Review for the Clinician.

Curr Treat Options Cardiovasc Med 2018 Sep 29;20(11):91. Epub 2018 Sep 29.

Knight Cardiovascular Institute, Oregon Health and Sciences University, 3181 Sam Jackson Park Road, UHN 62, Portland, OR, 97239, USA.

Purpose Of Review: This review summarizes the pathophysiology, diagnosis, and treatment of peripartum cardiomyopathy (PPCM), with a focus on recent discoveries of clinical relevance.

Recent Findings: An increase in oxidative stress and anti-angiogenic activity play key roles in the pathophysiology of peripartum cardiomyopathy. Therapies that target this dysregulation may have a future role in treatment. Read More

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http://dx.doi.org/10.1007/s11936-018-0690-3DOI Listing
September 2018
17 Reads

Imaging and Management of Heart Failure and Preserved Ejection Fraction.

Curr Treat Options Cardiovasc Med 2018 Sep 27;20(11):90. Epub 2018 Sep 27.

Cardiovascular Imaging Research Group, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria, 3004, Australia.

Purpose Of Review: The prevalence of heart failure with preserved ejection fraction (HFpEF) is rising and in some places, it is already the most prevalent form of heart failure. The usual treatments of HF do not improve mortality or outcomes in HFpEF, suggesting a distinct pathophysiology that remains poorly characterized. The neutrality of clinical trial results is also attributable to the heterogeneity of patient profiles, and by poor characterization offered by classical echocardiography parameters. Read More

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http://link.springer.com/10.1007/s11936-018-0689-9
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http://dx.doi.org/10.1007/s11936-018-0689-9DOI Listing
September 2018
19 Reads

Coronary Artery Calcium: Recommendations for Risk Assessment in Cardiovascular Prevention Guidelines.

Curr Treat Options Cardiovasc Med 2018 Sep 26;20(11):89. Epub 2018 Sep 26.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins Medical Institutions, Blalock 524D1, 600 N Wolfe St, Baltimore, MD, 21287, USA.

Purpose Of Review: In this review, we evaluate the coronary artery calcium (CAC) score as a biomarker for advanced atherosclerotic cardiovascular disease (ASCVD) risk assessment.

Recent Findings: We summarize the evidence from multiple epidemiological studies, which show a clear advantage of CAC compared to traditional and non-traditional cardiovascular risk factors. We then compare the recommendations included in the 2013 American College of Cardiology/American Heart Association (ACC/AHA) and in the 2017 Society of Cardiovascular Computed Tomography (SCCT) guidelines for the use of CAC in ASCVD risk assessment, and examine the recent 2018 US Preventive Services Task Force (USPSTF) document. Read More

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http://dx.doi.org/10.1007/s11936-018-0685-0DOI Listing
September 2018
1 Read

Disparities in Cardiac Care of Women: Current Data and Possible Solutions.

Curr Treat Options Cardiovasc Med 2018 Sep 21;20(11):87. Epub 2018 Sep 21.

Department of Cardiovascular Disease, 200 1st street SW, Rochester, MN, 55901, USA.

Purpose Of Review: Cardiovascular disease remains the leading cause of death in women. The goal of this review is to address known disparities in cardiovascular care with regard to diagnosis and treatment of heart disease in women.

Recent Findings: Gender-specific differences in regard to the incidence, treatment, and outcomes of common cardiovascular pathology are increasingly recognized. Read More

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http://dx.doi.org/10.1007/s11936-018-0688-xDOI Listing
September 2018
9 Reads

Sex Differences in the Management of Advanced Heart Failure.

Curr Treat Options Cardiovasc Med 2018 Sep 21;20(11):88. Epub 2018 Sep 21.

Massachusetts General Hospital, 55 Fruit Street GRB-800, Boston, MA, 02114, USA.

Purpose Of Review: Heart failure (HF) is prevalent among women and remains a leading cause of morbidity and mortality in the United States. Currently, 3 million women live with HF and the prevalence is projected to continue to increase. The purpose of this review is to highlight sex differences in the use and response to evidence-based pharmacological, device, and advanced HF therapies, as well as explore emerging areas of research in sex differences in the treatment of HF. Read More

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http://dx.doi.org/10.1007/s11936-018-0687-yDOI Listing
September 2018
1 Read

The Role of Cardiovascular Magnetic Resonance in Sports Cardiology; Current Utility and Future Perspectives.

Curr Treat Options Cardiovasc Med 2018 Aug 31;20(10):86. Epub 2018 Aug 31.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK.

Purpose Of Review: Cardiovascular magnetic resonance (CMR) is frequently used in the investigation of suspected cardiac disease in athletes. In this review, we discuss how CMR can be used in athletes with suspected cardiomyopathy with particular reference to volumetric analysis and tissue characterization. We also discuss the finding of non-ischaemic fibrosis in athletes describing its prevalence, distribution and clinical importance. Read More

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http://link.springer.com/10.1007/s11936-018-0679-y
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http://dx.doi.org/10.1007/s11936-018-0679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132733PMC
August 2018
11 Reads

The "Extreme Exercise Hypothesis": Recent Findings and Cardiovascular Health Implications.

Curr Treat Options Cardiovasc Med 2018 Aug 28;20(10):84. Epub 2018 Aug 28.

Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, MI, USA.

Purpose Of Review: The "Extreme Exercise Hypothesis" is characterized by a U-shaped or reverse J-shaped, dose-response curve between physical activity volumes and cardiovascular health outcomes. In this review, we summarize recent findings that may support or refute the "Extreme Exercise Hypothesis." Furthermore, we discuss potential cardiovascular health implications of the cardiac anatomical, structural, contractility, and biomarker abnormalities that have been reported in some veteran endurance athletes. Read More

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http://dx.doi.org/10.1007/s11936-018-0674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132728PMC
August 2018
12 Reads

Cardiac Screening of Young Athletes: a Practical Approach to Sudden Cardiac Death Prevention.

Curr Treat Options Cardiovasc Med 2018 Aug 28;20(10):85. Epub 2018 Aug 28.

Cardiovascular Sciences Research Centre, St George's University of London, London, UK.

Purpose Of Review: We aim to report on the current status of cardiovascular screening of athletes worldwide and review the up-to-date evidence for its efficacy in reducing sudden cardiac death in young athletes.

Recent Findings: A large proportion of sudden cardiac death in young individuals and athletes occurs during rest with sudden arrhythmic death syndrome being recognised as the leading cause. The international recommendations for ECG interpretation have reduced the false-positive ECG rate to 3% and reduced the cost of screening by 25% without compromising the sensitivity to identify serious disease. Read More

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http://dx.doi.org/10.1007/s11936-018-0681-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132782PMC
August 2018
1 Read

Sex Differences in Atrial Fibrillation-Update on Risk Assessment, Treatment, and Long-Term Risk.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):79. Epub 2018 Aug 27.

Rush Heart Center for Women, 1725 W. Harrison St. Suite 1159, Chicago, IL, 60612-3864, USA.

Purpose Of Review: Atrial fibrillation (AF) is a growing health problem worldwide. While the disease plagues both men and women, this arrhythmia does not affect both sexes equally. Women are more likely to have major adverse outcomes such as stroke and its sequela; however, recent data on stroke prevention show improving outcomes. Read More

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http://dx.doi.org/10.1007/s11936-018-0682-3DOI Listing
August 2018
1 Read

Assessment of the QT Interval in Athletes: Red Flags and Pitfalls.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):82. Epub 2018 Aug 27.

MQ Health Cardiology, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia.

Purpose Of Review: Pre-participation athlete screening has led to the referral of asymptomatic athletes with a prolonged QT interval warranting their evaluation for long QT syndrome (LQTS). Establishing a diagnosis of LQTS can be difficult, particularly in asymptomatic athletes presenting with a prolonged QTc < 500 ms. This review examines the evaluatory pathway to ascertain the common pitfalls leading to mis- or overdiagnosis. Read More

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http://dx.doi.org/10.1007/s11936-018-0678-zDOI Listing
August 2018
1 Read

The Global Burden of Cardiovascular Disease in Women.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):81. Epub 2018 Aug 27.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Blake 256, Boston, MA, 02114-2696, USA.

Purpose Of Review: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for one third of all deaths in 2015. Alarmingly, there has been slowing of the decline in age-standardized CVD mortality over the last 5 years compared to the previous 25 years.

Recent Findings: Given the increasing global CVD burden, in 2011, the United Nations declared the goal to reduce premature mortality from the four main non-communicable diseases by 25% from 2010 to 2025, abbreviated as the 25 × 25 goal. Read More

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http://dx.doi.org/10.1007/s11936-018-0676-1DOI Listing
August 2018
1 Read

Speckle Tracking Echocardiography for the Assessment of the Athlete's Heart: Is It Ready for Daily Practice?

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):83. Epub 2018 Aug 27.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Liverpool, L3 3AF, UK.

Purpose Of Review: To describe the use of speckle tracking echocardiography (STE) in the biventricular assessment of athletes' heart (AH). Can STE aid differential diagnosis during pre-participation cardiac screening (PCS) of athletes?

Recent Findings: Data from recent patient, population and athlete studies suggest potential discriminatory value of STE, alongside standard echocardiographic measurements, in the early detection of clinically relevant systolic dysfunction. STE can also contribute to subsequent prognosis and risk stratification. Read More

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http://dx.doi.org/10.1007/s11936-018-0677-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132779PMC
August 2018
2 Reads

Imaging of the Postsurgical Aorta in Marfan Syndrome.

Curr Treat Options Cardiovasc Med 2018 Aug 27;20(10):80. Epub 2018 Aug 27.

Department of Radiology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Box 141, New York, NY, 10065, USA.

Marfan syndrome is a heritable multisystem connective tissue disease and is the most common genetic cause of aortic disease. Guidelines for surgical repair and recommendations for surveillance imaging aim to prevent aneurysm rupture, aortic dissection, and death. Options for proximal aorta repair include the modified Bentall procedure and valve-sparing aortic root repairs. Read More

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http://dx.doi.org/10.1007/s11936-018-0675-2DOI Listing
August 2018
13 Reads

Cardiac Rehabilitation and Exercise Prescription in Symptomatic Patients with Non-Obstructive Coronary Artery Disease-a Systematic Review.

Curr Treat Options Cardiovasc Med 2018 Aug 18;20(9):78. Epub 2018 Aug 18.

Emergency, Cardiovascular and Critical Care Research Group, Faculty of Health, Social Care and Education (Joint Faculty), Kingston University & St George's University of London, London, UK.

Purpose Of Review: Non-obstructive coronary artery disease (NOCAD) on coronary angiography is a common finding in patients with stable angina. Angina in NOCAD patients is thought to be caused by endothelial dysfunction of the epicardial coronary arteries and/or the microvasculature. Treatment is empiric, and 30% of patients remain symptomatic in spite of therapy. Read More

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http://dx.doi.org/10.1007/s11936-018-0667-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105244PMC
August 2018
13 Reads

Multi-Modality Imaging in the Evaluation and Treatment of Tricuspid Regurgitation.

Curr Treat Options Cardiovasc Med 2018 Aug 9;20(9):77. Epub 2018 Aug 9.

Division of Cardiology, Department of Medicine, NewYork Presbyterian Hospital-Weill Cornell Medicine, 520 E 70th St, Starr 4, New York, NY, 10021, USA.

Purpose Of Review: The goal of this review is to cover the epidemiology of tricuspid regurgitation (TR), anatomy of the tricuspid valve (TV), and the mechanisms and modern treatment of TR. The focus will be on the role of echocardiography, cardiac CT, and MRI to determine the mechanism, severity, and management strategies of TR.

Recent Findings: The evaluation and management of TR is a rapidly growing field with significant advances in both imaging and interventions. Read More

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http://dx.doi.org/10.1007/s11936-018-0672-5DOI Listing
August 2018
8 Reads

Specialized Care for Women: the Impact of Women's Heart Centers.

Curr Treat Options Cardiovasc Med 2018 Aug 8;20(9):76. Epub 2018 Aug 8.

Rush Heart Center for Women, Rush University Medical Center, Chicago, IL, USA.

Purpose Of The Review: Cardiovascular disease (CVD) has been and remains the leading cause of mortality in women in the United States. For decades, more women died every year of CVD compared to men. Heart centers for women (HCW) are developed in response to the need for greater patient and physician awareness of CVD in women and to conduct sex-specific research in women. Read More

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http://dx.doi.org/10.1007/s11936-018-0656-5DOI Listing
August 2018
11 Reads

DVT Intervention in the Post-ATTRACT Era.

Curr Treat Options Cardiovasc Med 2018 Aug 6;20(9):70. Epub 2018 Aug 6.

Department of Radiology, Division of Interventional Radiology, New York University-Langone School of Medicine, 660 1st Avenue, Room 318, New York, NY, 10016, USA.

Purpose Of Review: Patients suffering from acute lower extremity deep vein thrombosis (DVT) are at risk for developing chronic limb pain, heaviness, and fatigue, known as the post-thrombotic syndrome (PTS).

Recent Findings: Although several studies have shown that catheter-directed therapy reduces clot burden and may improve clinical outcomes, the multicenter randomized controlled ATTRACT trial showed no difference in PTS or quality of life at 2 years between patients treated with pharmacomechanical catheter-directed thrombolysis (PCDT) and those treated with anticoagulation alone, and a higher major bleeding rate in the PCDT group. PCDT is not indicated for most patients diagnosed with lower extremity DVT. Read More

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http://dx.doi.org/10.1007/s11936-018-0663-6DOI Listing
August 2018
5 Reads

Updates on the Role of Imaging in Cardiac Sarcoidosis.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):74. Epub 2018 Aug 7.

Department of Internal Medicine, Kettering Medical Center, Dayton, OH, USA.

Purpose Of Review: The non-specific symptom profile and subclinical nature of disease along with variable region of cardiac involvement in systemic sarcoidosis make the diagnosis particularly challenging. The yield of endomyocardial biopsy, a gold standard for diagnosis, is not high unless coupled with additional imaging modalities to detect regional involvement. This review is focused on highlighting the major recent advances in imaging modalities and diagnosis of cardiac sarcoidosis. Read More

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http://dx.doi.org/10.1007/s11936-018-0670-7DOI Listing
August 2018
17 Reads

State-of-the-Art Imaging for the Evaluation of Pulmonary Embolism.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):71. Epub 2018 Aug 7.

Department of Radiology, Perelman School of Medicine of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Purpose Of Review: CT angiography has become the gold standard for evaluation of suspected pulmonary embolism; however, continuous evolution in radiology has led to new imaging approaches that offer improved options for detection and characterization of pulmonary embolism while exposing patients to lower contrast and radiation dose. The purpose of this review is to summarize state of the art imaging approaches for the evaluation of pulmonary embolism, focusing on technical innovations in this field.

Recent Findings: The introduction of dual-energy CT has resulted in the ability to add functional and prognostic information beyond the morphologic assessment of the pulmonary arteries and potentially offer improved image quality without additional radiation burden. Read More

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http://dx.doi.org/10.1007/s11936-018-0671-6DOI Listing
August 2018
1 Read

Stable Ischemic Heart Disease in Women.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):72. Epub 2018 Aug 7.

Division of Cardiovascular Medicine, Departments of Medicine and Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Avenue, Madison, WI, 53792-3248, USA.

Purpose Of The Review: Paradoxically, although women have a lower burden of coronary atherosclerosis, they experience more symptoms, more frequent hospitalizations, and a worse prognosis compared to men. This is in part due to biological variations in pathophysiology between the two sexes, and in part related to inadequate understanding of these differences, subconscious referral bias, and suboptimal application of existing women-specific guidelines. We sought to review the contemporary literature and provide an update on risk assessment, diagnosis, and management of IHD in women. Read More

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http://dx.doi.org/10.1007/s11936-018-0665-4DOI Listing
August 2018
5 Reads

Advances in Mitral Valve Surgery.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):75. Epub 2018 Aug 7.

Department of Cardiac Surgery, Leipzig Heart Center, University of Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany.

Mitral valve (MV) insufficiency, classified as primary and secondary mitral regurgitation (MR), is a common cause of morbidity and mortality. In industrialized countries, degenerative forms are the predominant cause of MR; however, an increasing number of patients present with secondary MR (Iung et al. EHJ 24:1231-1243, 2003). Read More

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http://dx.doi.org/10.1007/s11936-018-0666-3DOI Listing
August 2018
2 Reads

Workup and Management of Native and Prosthetic Valve Endocarditis.

Curr Treat Options Cardiovasc Med 2018 Aug 7;20(9):73. Epub 2018 Aug 7.

Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USA.

Infective endocarditis (IE) is associated with significant serious adverse outcomes including death. IE usually presents with diverse clinical picture and syndromic diagnoses including heart failure, stroke, and peripheral embolization. Given variable, vague, and syndromic presentations, the diagnosis of IE may be delayed for days to weeks. Read More

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http://dx.doi.org/10.1007/s11936-018-0668-1DOI Listing
August 2018
8 Reads

Management of Venous Thromboembolism in Pregnancy.

Curr Treat Options Cardiovasc Med 2018 Jul 23;20(8):69. Epub 2018 Jul 23.

Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.

Purpose Of Review: This manuscript addresses the risks for venous thromboembolism (VTE) during pregnancy and the associated challenges of both diagnosis and treatment.

Recent Findings: The obstacles to diagnosis given lack of specificity of typical biomarkers to predict VTE in pregnancy, as well as the unique fetal and bleeding risks introduced by managing massive pulmonary embolism (PE) with thrombolytics or thrombectomy are highlighted. VTE during pregnancy and the postpartum window occurs at a 6-10-fold higher rate compared with age-matched peers and is a major cause of morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s11936-018-0658-3DOI Listing
July 2018
6 Reads

Cardiac Adaption to Exercise Training: the Female Athlete.

Curr Treat Options Cardiovasc Med 2018 Jul 18;20(8):68. Epub 2018 Jul 18.

Massachusetts General Hospital Cardiovascular Performance Program, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5B, Boston, MA, 02114, USA.

Purpose Of Review: The number of female athletes participating in sports has increased exponentially over the past century. While cardiac adaptations to exercise have been well described, female athletes have been underrepresented in many prior studies. More recently, important research has embraced gender as an important biologic variable. Read More

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http://dx.doi.org/10.1007/s11936-018-0659-2DOI Listing
July 2018
12 Reads

Arteriovenous Malformations: Syndrome Identification and Vascular Management.

Curr Treat Options Cardiovasc Med 2018 Jul 18;20(8):67. Epub 2018 Jul 18.

The AVM Center at Lenox Hill, Lenox Hill Heart & Vascular Institute, New York, NY, USA.

Purpose Of Review: Vascular malformations represent a poorly understood set of conditions that create considerable diagnostic and therapeutic confusion. Historically, extensive surgical resections yielded poor results. More recently, the treatment paradigm has shifted to endovascular therapy such that embolization and sclerotherapy are now considered the first line of treatment. Read More

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http://dx.doi.org/10.1007/s11936-018-0662-7DOI Listing
July 2018
3 Reads

Iron Deficiency in Heart Failure: to Treat or Not to Treat?

Curr Treat Options Cardiovasc Med 2018 Jul 18;20(8):65. Epub 2018 Jul 18.

Portsmouth Hospitals NHS Trust, Portsmouth, UK.

Purpose Of Review: This review will highlight the frequency and prognostic importance of iron deficiency in patients with chronic heart failure. An overview of the evidence surrounding the use of both oral and intravenous iron will be presented together with discussion around what further data are required to establish what is the optimal long-term treatment strategy.

Recent Findings: Several recent randomised controlled studies have suggested that intravenous iron therapy in iron deficient patients with chronic heart failure and reduced ejection fraction can improve symptoms and quality of life, at least in the short term. Read More

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http://dx.doi.org/10.1007/s11936-018-0661-8DOI Listing
July 2018
4 Reads