3,131 results match your criteria Current Topics in Medicinal Chemistry [Journal]


Targeting Epigenetic Targets for Cancer Therapy.

Authors:
Bin Yu

Curr Top Med Chem 2018 ;18(28):2379

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases Children's Hospital Affiliated to Zhengzhou University Zhengzhou Children's Hospital. School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 45001, China.

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http://dx.doi.org/10.2174/156802661828190212093039DOI Listing
January 2018

Current Advances in Computational Approaches for Drug Discovery- Part II.

Authors:
Amit K Gupta

Curr Top Med Chem 2018 ;18(27):2267

Keck Computational Biology Fellow Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston TX 77030, United States.

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http://dx.doi.org/10.2174/156802661827190123105909DOI Listing
January 2018
3 Reads

Quinoline-based protein-protein interaction inhibitors of LEDGF/p75 and HIV integrase: An in silico study.

Curr Top Med Chem 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, 151001. India.

The failure of the Integrase Strand Transfer Inhibitors (INSTIs) due to the mutations occurring at catalytic site of HIV integrase (IN) has led to the design of allosteric integrase inhibitors (ALLINIs). Lens epithelium derived growth factor (LEDGF/p75) is the host cellular cofactor helps chaining IN to the chromatin. The protein-protein interactions (PPIs) were observed at allosteric site (LEDGF/p75 binding domain) between LEDGF/p75 of host cell and IN of virus. Read More

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http://dx.doi.org/10.2174/1568026619666190208164801DOI Listing
February 2019
3.402 Impact Factor

Novel pyrazolo [4, 3-c] quinolin-3-one derivatives as PDE5A inhibitors.

Curr Top Med Chem 2019 Feb 8. Epub 2019 Feb 8.

Discipline of Chemistry, Indian Institute of Technology Gandhinagar, Gujarat. India.

PDE5A is a phosphodiesterase which specifically hydrolyzes the cGMP to GMP. PDE5A takes part in several physiological and pathological pathways and is considered an important drug target. Currently, PDE5 inhibitors (ex; Sildenafil, Tadalafil) available in the market are not only being used for the treatment of erectile dysfunction but at the same time, they are also in the clinical trials being investigated as anticancer agents. Read More

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http://dx.doi.org/10.2174/1568026619666190208164402DOI Listing
February 2019

Mathematical and Computational Techniques for Drug Discovery: Promises and Developments.

Curr Top Med Chem 2019 Feb 8. Epub 2019 Feb 8.

School of Molecular Sciences , Arizona State University. United States.

We review various mathematical and computational techniques for drug discovery exemplifying some recent works pertinent to group theory of nested structures of relevance to phylogeny, topological, computational and combinatorial methods for drug discovery for multiple viral infections. We have reviewed techniques from topology, combinatorics, graph theory and knot theory that facilitate topological and mathematical characterizations of protein-protein interactions, molecular-target interactions, proteomics, genomics and statistical data reduction procedures for a large set of starting chemicals in drug discovery. We have provided an overview of group theoretical techniques pertinent to phylogeny, protein dynamics especially in intrinsically disordered proteins, DNA base permutations and related algorithms. Read More

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http://dx.doi.org/10.2174/1568026619666190208164005DOI Listing
February 2019
2 Reads

In-silico design, synthesis of hybrid combinations: Quercetin based MAO inhibitors with Antioxidant potential.

Curr Top Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Faculty of Pharmaceutical Sciences, M. D. University, Rohtak. India.

Background: Monoamine oxidase (MAO) is a critical target used for the cure of neuropsychological diseases.

Objective: A series of quercetin based derivatives was designed, synthesized, and evaluated as novel multifunctional agents against monoamine oxidase A and B with antioxidant potential.

Method: Hybrid derivatives based on quercetin were synthesized and screened for hMAO inhibition along with antioxidant activity. Read More

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http://dx.doi.org/10.2174/1568026619666190212122403DOI Listing
February 2019

In silico and 3D QSAR Studies of Natural Based Derivatives as Xanthine oxidase Inhibitors.

Curr Top Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Laboratory for Preservation Technology and Enzyme Inhibition Studies, Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana. India.

Background: A large number of disorders and their symptoms emerge from deficiency or overproduction of specific metabolites has drawn the attention for discovery of new therapeutic agents for the treatment of disorders. Various approaches such as computational drug design have provided the new methodology for the selection and evaluation of target protein and the lead compound mechanistically. For instance, the overproduction of xanthine oxidase causes the accumulation of uric acid which can prompted gout. Read More

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http://dx.doi.org/10.2174/1568026619666190206122640DOI Listing
February 2019
1 Read

Small molecule natural products and Alzheimer's disease.

Curr Top Med Chem 2019 Feb 1. Epub 2019 Feb 1.

PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut 06520. United States.

Alzheimer's disease (AD) is a progressive and deadly neurodegenerative disease that is characterized by memory loss, cognitive impairment and dementia. Several hypotheses have been proposed for the pathogenesis based on the pathological changes in brain of AD patients during last few decades. But unfortunately, there were no effective agents/therapies to prevent or control AD at present. Read More

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http://dx.doi.org/10.2174/1568026619666190201153257DOI Listing
February 2019
1 Read

PTP1B Inhibition, A Promissing Approach For The Treatment Of Diabetes Type Ii.

Curr Top Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmacy School of Health, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124. Greece.

Background: Diabetes mellitus (DM), is a metabolic disorder characterized by high blood glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes mellitus type II, gestational diabetes and Diabetes of other etiology. Diabetes type II, the non insulin dependent type (NIDDM) is the most common type, characterized by the impairment in activation of the intracellular mechanism leading to the insertion and usage of glucose after interaction of insulin with its receptor, known as insulin resistance. Read More

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http://dx.doi.org/10.2174/1568026619666190201152153DOI Listing
February 2019
3.402 Impact Factor

Current Advances in Computational Approaches for Drug Discovery- Part I.

Authors:
Amit K Gupta

Curr Top Med Chem 2018 ;18(26):2201

Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, United States.

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http://dx.doi.org/10.2174/156802661826190124120035DOI Listing
January 2018

Progress in Antiparasitic Drug Discovery: From the Laboratory Bench to the Collaborative Initiatives.

Curr Top Med Chem 2018 ;18(26):2199-2200

ARNA unit "RNA: Natural and Artificial Regulation", University of Bordeaux / INSERM U1212 / CNRS UMR5320, European Institute of Chemistry and Biology (IECB), 2, Rue Robert Escarpit, 33607, Pessac, France.

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http://dx.doi.org/10.2174/156802661826190124115834DOI Listing
January 2018

Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design.

Curr Top Med Chem 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036. Cyprus.

Background: The biotransformation of xenobiotics is a homeostatic defensive response of the body against bioactive invaders. Xenobiotic metabolizing enzymes, important for the metabolism, elimination and detoxification of exogenous agents, are found in most tissues and organs and are distinguished into phase I and phase II enzymes, as well as phase III transporters. The cytochrome P450 superfamily of enzymes plays a major role in the biotransformation of most xenobiotics as well as in the metabolism of important endogenous substrates such as steroids and fatty acids. Read More

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http://dx.doi.org/10.2174/1568026619666190129122727DOI Listing
January 2019

Design, synthesis, evaluation of antimicrobial activity and docking studies of thiazole-based chalcones.

Curr Top Med Chem 2019 01 29. Epub 2019 Jan 29.

Department of Biotechnology and Food Technology, Faculty of Applied Sciences, Durban University of Technology, Durban 4001. South Africa.

Background: Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial.

Objectives: The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones. Read More

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http://dx.doi.org/10.2174/1568026619666190129121933DOI Listing
January 2019
3.402 Impact Factor

Target Enzyme in Alzheimer's Disease:Acetylcholinesterase Inhibitors.

Curr Top Med Chem 2019 Jan 28. Epub 2019 Jan 28.

Amity School of Applied Sciences, Amity University, Lucknow-226010. India.

Alzheimer's disease (AD), affecting a large population worldwide is characterized by the loss of memory and learning ability in the old population. The enzyme acetylcholinesterase enzyme (AChE) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of AD but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. To review the development of different strategies targeting the AChE enzyme along with other targets like butyl cholinesterase (BChE), amyloid-β (Aβ), β-secretase-1 (BACE), metals antioxidant properties and free radical scavenging capacity focused in recent years. Read More

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http://dx.doi.org/10.2174/1568026619666190128125912DOI Listing
January 2019

Radionuclide-Labeled Peptides for Imaging and Treatment of CXCR4-Overexpressing Malignant Tumors.

Curr Top Med Chem 2019 Jan 31. Epub 2019 Jan 31.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University. No. 25, Taiping St, Luzhou, Sichuan 646000. China.

Malignant tumors are a major cause of death. The lack of methods that provide an early diagnosis and adequate treatment of cancers is the main obstacle to precision medicine. The C-X-C chemokine receptor 4 (CXCR4) is overexpressed in various tumors and plays a key role in tumor pathogenesis. Read More

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http://dx.doi.org/10.2174/1568026619666190201094952DOI Listing
January 2019

Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals.

Curr Top Med Chem 2019 Jan 31. Epub 2019 Jan 31.

Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, 610041, Chengdu. China.

Background: Prostate cancer (PCa) is the most common sex-related malignancy with high mortality in men worldwide. Prostate-specific membrane antigen (PSMA) is overexpressed on the surface of most prostate tumor cells and considered a valuable target for both the diagnosis and therapy of prostate cancer. A series of radiolabeled agents have been developed based on the featured PSMA ligands in the previous decade and have demonstrated promising outcomes in clinical research of primary and recurrent PCa. Read More

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http://dx.doi.org/10.2174/1568026619666190201100739DOI Listing
January 2019
10 Reads

High Throughput Metabolomics in Clinical Studies: Review and New Applications to Remote Ischemic Preconditioning.

Curr Top Med Chem 2018 ;18(25):2143-2153

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, United States.

Metabolomic analysis has made substantial contributions to the understanding of diverse pathological processes and has the potential to improve diagnosis and identify novel therapeutic targets. As early success in perinatal medicine, nutrition, chronic diseases, cancer and trauma demonstrates, metabolomics is approaching feasibility in terms of guiding improvement in population-level diagnosis and treatment. A key barrier to implementing metabolomics as a routine diagnostic tool is rapid sample extraction and data analysis along with the establishment of normal values for novel metabolic markers. Read More

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http://dx.doi.org/10.2174/1568026619666181130140937DOI Listing
January 2018

Therapeutics against Trypanosomiasis.

Curr Top Med Chem 2018 ;18(25):2138-2140

ICAR-National Research Centre on Equines, Sirsa Road, Hisar-125001, Haryana, India.

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http://dx.doi.org/10.2174/156802661825190118123359DOI Listing
January 2018
1 Read

HIV-Challenges for Human.

Curr Top Med Chem 2018 ;18(25):2136-2137

Member of Mediterranean and European, Academies of Science and Arts, School of Pharmacy, Aristotle University, of Thessaloniki, Thessaloniki 54124, Greece.

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http://dx.doi.org/10.2174/156802661825190118123243DOI Listing
January 2018

Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery.

Curr Top Med Chem 2019 Jan 25. Epub 2019 Jan 25.

Institute of Medical Engineering, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No.76 Yanta West Road, Xi'an, Shaanxi 710061. China.

Enzymatic dysregulation in tumor and intracellular microenvironments has made this property a tremendously promising responsive element for efficient diagnostics, carrier targeting, and drug release. When combined with nanotechnology, enzyme-responsive drug delivery systems (DDSs) have achieved substantial advancements. In the first part of this tutorial review, changes in tumor and intracellular microenvironmental factors, particularly the enzymatic index, are described. Read More

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http://dx.doi.org/10.2174/1568026619666190125144621DOI Listing
January 2019

Research advances in the use of histone deacetylase inhibitors for epigenetic targeting of cancer.

Curr Top Med Chem 2019 Jan 25. Epub 2019 Jan 25.

School of Pharmacy, Jilin Medical University, Jilin. China.

The causes and progression of cancer are controlled by epigenetic processes, and thus the mechanisms involved in epigenetic regulation of cancer development and gene expression, gene and signaling pathways have been studied. Histone deacetylases (HDACs) have a major impact on chromatin remodeling and epigenetics, making their inhibitors a very interesting area of research. This review is a comprehensive report on the literature published in the past few years. Read More

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http://dx.doi.org/10.2174/1568026619666190125145110DOI Listing
January 2019

Nanoparticle Therapy for Prostate Cancer: overview and perspectives.

Curr Top Med Chem 2019 Jan 25. Epub 2019 Jan 25.

Department of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107. China.

Traditional prostate cancer therapy and especially chemotherapy has faced many challenges. Low accumulation levels, rapid clearance or drug resistance at the tumor site have been central to why the effect of chemotherapy drugs has declined. Applications of nanotechnology to biomedicine have enabled the development of nanoparticle therapeutic carriers suited for the delivery of chemotherapeutics in cancer therapy. Read More

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http://dx.doi.org/10.2174/1568026619666190125145836DOI Listing
January 2019

Peptides as Potential Anticancer Agents.

Curr Top Med Chem 2019 Jan 25. Epub 2019 Jan 25.

School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi. India.

Cancer consists of heterogeneous multiple cell subpopulation which at a later stage develop resistant phenotypes, which include resistance to pro-apoptotic stimuli and/or cytotoxic resistance to anticancer compounds. The property of cancerous cells to affect almost any part of the body categorizes cancer to many anatomic and molecular subtypes, each requiring particular therapeutic intervention. As several modalities are hindered in a variety of cancers and as the cancer cells accrue varied types of oncogenic mutations during their progression the most likely benefit will be obtained by combination of therapeutic agents that might address the diverse hallmarks of cancer. Read More

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http://dx.doi.org/10.2174/1568026619666190125161517DOI Listing
January 2019
2 Reads

Recent Tools to Overcome Antibacterial Resistance.

Authors:
Ivana Cacciatore

Curr Top Med Chem 2018 ;18(24):2067

Department of Pharmacy University "G. d'Annunzio" of Chieti-Pescara Via dei Vestini 31 Chieti Scalo (CH), Italy.

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http://dx.doi.org/10.2174/156802661824190112120932DOI Listing
January 2018

Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes.

Curr Top Med Chem 2019 Jan 23. Epub 2019 Jan 23.

Institute of Biomedical Chemistry, Moscow. Russian Federation.

Drug-drug interaction (DDI) is a phenomenon of alteration of the pharmacological activity of a drug(s) when another drug(s) is co-administrated in case of so-called polypharmacy. There are three types of DDIs: pharmacokinetic (PK), pharmacodynamic, and pharmaceutical. PK is the most frequent type of DDI, and often it appears as a result of inhibition or induction of drug-metabolizing enzymes (DME). Read More

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http://dx.doi.org/10.2174/1568026619666190123160406DOI Listing
January 2019
1 Read

New caffeic acid derivatives as antimicrobial agents: design, synthesis, evaluation and docking.

Curr Top Med Chem 2019 Jan 22. Epub 2019 Jan 22.

Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade. Serbia.

Background: Phenolic acids (caffeic-, ferulic and p-coumaric acid) are widely distributed in the plant kingdom and exhibit broad spectrum of biological activities, including antimicrobial activity.

Objective: The goal of this paper is synthesis of some caffeic acid derivatives selected based on computer-aided predictions and evaluate their in vitro antimicrobial properties against Gram positive and Gram negative bacteria and also a series of fungi.

Methods: In silico prediction of biological activity was used to identify the most promising structures for synthesis and biological testing, and the putative mechanisms of their antimicrobial action. Read More

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http://dx.doi.org/10.2174/1568026619666190122152957DOI Listing
January 2019
1 Read
3.402 Impact Factor

Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery.

Curr Top Med Chem 2019 Jan 22. Epub 2019 Jan 22.

Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405. China.

Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and anti-inflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Read More

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http://dx.doi.org/10.2174/1568026619666190122151634DOI Listing
January 2019
4 Reads

Zinc-dependent deacetylase (HDAC) inhibitors with different ZBG groups.

Curr Top Med Chem 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004. China.

The state of histone acetylation plays a very crucial role in carcinogenesis and its development by chromatin remodeling and thus altering transcription of oncogenes and tumor suppressor genes. Such epigenetic regulation was controlled by zinc-dependent histone deacetylases (HDACs), one of major regulators. Due to the therapeutic potential of HDACs as one of promising drug targets in cancer, HDAC inhibitors have been intensively investigated over last few decades. Read More

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http://www.eurekaselect.com/169245/article
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http://dx.doi.org/10.2174/1568026619666190122144949DOI Listing
January 2019
3 Reads
3.402 Impact Factor

Biological Activities of Artemisinin Derivatives Beyond Malaria.

Curr Top Med Chem 2019 Jan 22. Epub 2019 Jan 22.

CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203. China.

Artemisinin is isolated from Artemisia annua L with peroxide-containing sesquiterpene lactone structure. Because of its unique structural characteristics and promising anticancer, antivirus activities, it has recently received increasing attention. The aim of this review is to summarize recent discoveries of artemisinin's novel derivatives with new pharmaceutical effects beyond malaria with a focus on its antitumor and antivirus activity, as well as potential results of combination therapy with other clinical drugs. Read More

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http://dx.doi.org/10.2174/1568026619666190122144217DOI Listing
January 2019

Combating Diseases with Computational Strategies used for Drug Design and Discovery.

Curr Top Med Chem 2019 Jan 21. Epub 2019 Jan 21.

Chemistry Department, Faculty of Sciences, University of Tehran, Tehran. Iran.

Computer-aided drug discovery (CADD) tools have provided an effective way in the drug discovery pipeline for expediting of this long process and economizing the cost of research and development. Because of the dramatic increase in the availability of human proteins as drug targets and small molecule information due to the advances in bioinformatics, cheminformatics, genomics, proteomics, and structural information, the applicability of in silico drug discovery has been extended. Computational approaches have been used at almost all stages in the drug discovery pipeline including target identification and validation, lead discovery and optimization, and pharmacokinetic and toxicity profiles prediction. Read More

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http://dx.doi.org/10.2174/1568026619666190121125106DOI Listing
January 2019
3 Reads

Acetate kinase (AcK) is essential for microbial growth and betel compounds potentially target AcK, PhoP, and MDR proteins in M. tuberculosis, V. cholerae, and pathogenic E. coli : An in silico and in vitro study.

Curr Top Med Chem 2019 01 20. Epub 2019 Jan 20.

PG program in Bioinformatics (LGCM), Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Mycobacterium tuberculosis, Vibrio cholerae, and pathogenic Escherichia coli are global concerns for public health. The emergence of multi-drug resistant (MDR) strains of these pathogens are creating additional challenges in controlling infections caused by these deadly bacteria. Recently, we reported that Acetate kinase (AcK) could be a broad-spectrum novel target in several bacteria including these pathogens. Read More

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http://dx.doi.org/10.2174/1568026619666190121105851DOI Listing
January 2019
4 Reads
3.402 Impact Factor

Drug Repurposing for Retinoblastoma: Recent Advances.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

CSIR- Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007. India.

Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortunately, these are associated with many side and late effects. Read More

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http://www.eurekaselect.com/169178/article
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http://dx.doi.org/10.2174/1568026619666190119152706DOI Listing
January 2019
5 Reads

Modern Computational Strategies for Designing Drugs to Curb Human Diseases: A Prospect.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Department of Biochemistry, University of Kashmir. India.

Drug discovery is an exhaustive and time consuming process involving numerous stages like target identification, validation, lead optimization, preclinical trials, clinical trials and finally post marketing vigilance for drug safety. The application of computer aided drug designing (CADD) is an indispensable approach for developing safe and effective drugs. Previous methods based on combinatorial chemistry (CC) and high throughput screening (HTS) consumed a lot of time as well as expenditure. Read More

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http://dx.doi.org/10.2174/1568026619666190119150741DOI Listing
January 2019
3 Reads
3.402 Impact Factor

Exploration of Novel 5α-Reductase Inhibitors for Benign prostatic Hyperplasia by 2D/3D QSAR, Cytotoxicity Pre-ADME and Docking Studies.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

University Institute of Pharmaceutical Sciences; Department of Pharmaceutical Chemistry Panjab University, Chandigarh -160014. India.

5α-Reductase (5AR) a NADPH dependent enzyme is expressed in most of the prostate epithelial cells. By converting testosterone (T) into more potent androgen dihydrotestosterone (DHT), it plays an important role in men physiology and represents an efficient therapeutic target for androgen dependent diseases. Over the last few years, significant efforts have been made in order to develop 5AR inhibitors (5ARI) to treat Benign Prostatic Hyperplasia because of excessive production of DHT. Read More

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http://dx.doi.org/10.2174/1568026619666190119145959DOI Listing
January 2019
1 Read

Screening of natural lead molecules against putative molecular targets of drug resistant Cryptococcus spp: an insight from computer aided molecular design.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Department of Biotechnology Engineering, Dayananda Sagar Institutions, Bengaluru, Karnataka, 560 078, Visvesvaraya Technological University. India.

Cryptococcosis is one of the major invasive fungal infections distributed worldwide with high mortality rate. C. neoformans and C. Read More

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http://dx.doi.org/10.2174/1568026619666190119145434DOI Listing
January 2019
3 Reads

Homology modeling and docking studies of Bcl-2 and Bcl-xL with small molecule inhibitors: identification and functional studies.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Department of Chemistry, Manipal Institute of Technology, Mainnipal Academy of Higher Education, Manipal-576104. India.

Apoptosis is a vital physiological process, which is observed in various biological events. The anti-apoptotic and pro-apoptotic members of Bcl-2 family are the most characterized proteins which are involved in the regulation of apoptotic cell death. The anti-apoptotic proteins such as Bcl-2 and Bcl-xL prevent apoptosis,whereas pro-apoptotic members like Bax and Bak, elicit the release of caspases from death antagonists inducing apoptosis. Read More

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http://dx.doi.org/10.2174/1568026619666190119144819DOI Listing
January 2019
3 Reads

Structure Based Drug Design: Clinically relevant HIV1 Integrase Inhibitors.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

ISF College of Pharmacy, Moga-142001, Punjab. India.

HIV-1 integrase, a member of a polynucleotidyl transferases superfamily, catalyze the insertion of the viral DNA into the genome of host cells. It has emerged as a potential target for developing anti-HIV agents. In last two decades, number of integrase inhibitors has been developed as potential anti-HIV therapeutics. Read More

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http://dx.doi.org/10.2174/1568026619666190119143239DOI Listing
January 2019
2 Reads

Role of 2-Dimensional autocorrelation descriptors in predicting Antimalarial Activity of Artemisinin and its analogues: A QSAR study.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Center for Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda. India.

Malaria one of the World's biggest billers' is on the schedule for biomedical research and public health policies. The introduction of the artemisinin, a Chinese traditional drug from Artemisia annua is a revolution in the treatment of malaria. Artemisinin-based combination treatment (ACT) is considered to be best strategy for uncomplicated Falciparum malaria. Read More

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http://dx.doi.org/10.2174/1568026619666190119143838DOI Listing
January 2019
1 Read
3.402 Impact Factor

Molecules Effective against Infectious Diseases - Part II.

Curr Top Med Chem 2019 ;18(23):2007

Department of Chemistry Miranda House, University of Delhi Delhi-110007, India.

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http://dx.doi.org/10.2174/156802661823190110114126DOI Listing
January 2019
1 Read

Perspective in Medicinal Chemistry.

Authors:
Dorina Lauritano

Curr Top Med Chem 2018 ;18(23):2000-2001

Department of Medicine and Surgery Universita degli Studi di Milano-Bicocca, UNIMIB Milan, Italy.

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http://dx.doi.org/10.2174/156802661823190110112258DOI Listing
January 2019
1 Read

Anti-infectious Drugs: Approaches and Achievements - Part I.

Curr Top Med Chem 2018 ;18(22):1925

Department of Chemistry Miranda House, University of Delhi Delhi-110007, India.

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http://dx.doi.org/10.2174/156802661822190110105011DOI Listing
January 2019
1 Read

Recent Therapeutic Advancements Using Bioinformatics and Chemoinformatics Approaches.

Curr Top Med Chem 2018 ;18(20):1717-1718

Department of Biotechnology Indian Institute of Technology Roorkee Roorkee -247667, Uttarakhand, India.

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http://www.eurekaselect.com/168644/article
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http://dx.doi.org/10.2174/156802661820181231102849DOI Listing
February 2019
2 Reads

SI Advances in Applied Neuroscience Research - Part II.

Curr Top Med Chem 2018 ;18(21):1856

Department of Psychiatry and Medical Psychology Head, Neuropsychiatry and Brain Imaging Group Medical University of Plovdiv Vice President, Bulgarian Academy of Sciences and Arts Vice Chair, PSIG, Royal College of Psychiatrists, Plovdiv, United Kingdom.

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http://dx.doi.org/10.2174/156802661821190104120707DOI Listing
January 2018
1 Read

From Darkness to Light: Pretargeted Radionuclide Imaging Driven by Tetrazine Bioorthogonal Chemistry.

Curr Top Med Chem 2018 ;18(21):1851-1855

Huaxi MR Research Center, Department of Radiology, West China Hospital and West China School of Medicine, Sichuan University, Chengdu (610041), China.

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http://dx.doi.org/10.2174/156802661821190104120031DOI Listing
January 2018
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GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications.

Curr Top Med Chem 2018 ;18(23):2002-2006

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

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http://dx.doi.org/10.2174/1568026619999190101151837DOI Listing
January 2019
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New Drugs and Therapeutic/Diagnostic Targets for Fungal and Parasitic Diseases - Part I.

Curr Top Med Chem 2018 ;18(15):1274

Departamento de Farmacia, Facultad de Ciencias de la Salud Universidad Cardenal Herrera-CEU, Moncada Valencia, 46113, Spain.

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http://dx.doi.org/10.2174/156802661815181101110430DOI Listing
January 2018
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Perspective: Striving Toward Reproducible Results in Blood-based Metabolomic Investigations for Brain Disorders.

Curr Top Med Chem 2018 ;18(15):1271-1273

Departments of Neurology, Neurological Surgery, and Anatomy & Neurobiology, University of California Irvine, School of Medicine, Irvine, CA 92697, United States.

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http://dx.doi.org/10.2174/156802661815181101110212DOI Listing
January 2018
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Perspectives in Applied Neuroscience Research - Part I.

Curr Top Med Chem 2018 ;18(19):1619-1620

Department of Psychiatry and Medical Psychology Head, Neuropsychiatry and Brain Imaging Group Medical University of Plovdiv Vice President, Bulgarian Academy of Sciences and Arts Vice Chair, PSIG, Royal College of Psychiatrists, United Kingdom.

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http://dx.doi.org/10.2174/156802661819181212120816DOI Listing
January 2018
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Epigenetic Targets and their Inhibitors in Cancer Therapy.

Curr Top Med Chem 2018 ;18(28):2395-2419

College of pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.

Epigenetics is defined as the stable and heritable alternations in gene expression without changing the DNA nucleotide sequence. The initiation and progression of cancer result from not only genetic mutation, but also aberrant epigenetic regulation, such as DNA methylation and histones acetylation. Although Genetic alternations cannot be reversed, epigenetic modification is a dynamic and reversible process. Read More

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http://dx.doi.org/10.2174/1568026619666181224095449DOI Listing
January 2018
26 Reads