19 results match your criteria Current Signal Transduction Therapy[Journal]

  • Page 1 of 1

Strategies of Functional Foods Promote Sleep in Human Being.

Curr Signal Transduct Ther 2014 Dec;9(3):148-155

Biotechnology and Genetic Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming 650205, P.R. China;

Sleep is a vital segment of life, however, the mechanisms of diet promoting sleep are unclear and are the focus of research. Insomnia is a general sleep disorder and functional foods are known to play a key role in the prevention of insomnia. A number of studies have demonstrated that major insomnia risk factors in human being are less functional foods in dietary. Read More

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http://dx.doi.org/10.2174/1574362410666150205165504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440346PMC
December 2014
13 Reads

Metastasis-Initiating Cells in Renal Cancer.

Curr Signal Transduct Ther 2014 Dec;8(3):240-246

Molecular Oncology Laboratory, Clinic of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.

Metastasis is a complex process that propagates cells from the primary or initial site of the cancer occurrence to distant parts of the body. Cancer cells break from the cancer site and circulate through the bloodstream or lymph vessels, allowing them to reach nearly all parts of the body. These circulating tumour cells (CTCs) contain specialized metastasis-initiating cells (MICs) that reside in the biological heterogeneous primary tumour. Read More

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http://dx.doi.org/10.2174/1574362409666140206222431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141324PMC
December 2014
11 Reads

Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC).

Curr Signal Transduct Ther 2014 Dec;8(3):218-228

Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine in Warsaw, Poland.

Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, overall response rate is still unsatisfactory. Read More

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http://dx.doi.org/10.2174/1574362409666140206223014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141325PMC
December 2014
22 Reads

Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma.

Curr Signal Transduct Ther 2014 Dec;8(3):210-218

Oncology Department, Laboratory of Molecular Oncology, Military nstitute of Medicine, Warsaw, Poland.

Mammalian target of rapamycin (mTOR) is a kinase protein involved in PI3K/AKT signaling with a central role in the processes of cell growth, survival and angiogenesis. Frequent mutations of this pathway make upstream and downstream components novel targets for tailored therapy design. Two mTOR inhibitors - everolimus and temsirolimus - enable an increase in overall survival (OS) or progression-free survival (PFS) time in a treatment of renal cancer. Read More

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http://dx.doi.org/10.2174/1574362409666140206222746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141323PMC
December 2014
17 Reads

Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops.

Curr Signal Transduct Ther 2013 Dec;8(3):193-202

Georg Speyer Haus, Institute for Biomedical Research, Frankfurt am Main, Germany.

The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and with duration of treatment. Intrinsic and acquired resistance against such drugs limits their efficacy. Read More

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http://dx.doi.org/10.2174/1574362409666140206221931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095943PMC
December 2013
14 Reads

Update on the Pathophysiological Role of Intracellular Signaling Pathways in Atherosclerotic Plaques and Ischemic Myocardium.

Curr Signal Transduct Ther 2012 May;7(2):104-110

Division of Cardiology, Foundation for Medical Researches, Department of Medical Specialties, University of Geneva, Geneva, Switzerland.

Acute atherosclerotic complications, such as myocardial infarction, are often provoked by the rupture of an atherosclerotic plaque and the subsequent thrombotic occlusion of the arterial lumen, which interrupts the blood flow and renders ischemic the downstream peripheral tissue. Several inflammatory mediators (including cytokines, chemokines and matrix metalloproteases) have been shown to orchestrate common pathophysiological mechanisms regulating both plaque vulnerability and myocardial injury. In particular, the selective activation of certain protective intracellular signaling pathways might represent a promising target to reduce the dramatic consequences of an ischemic cardiac event. Read More

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http://www.eurekaselect.com/openurl/content.php?genre=articl
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http://dx.doi.org/10.2174/157436212800376663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382259PMC
May 2012
10 Reads

Role of fibroblast growth factor receptors in astrocytic stem cells.

Curr Signal Transduct Ther 2012 Jan;7(1):81-86

Neuroscience Lab, Facultad de Psicologia, Universidad de Colima, Colima, Mexico 28040.

There are two well-defined neurogenic regions in the adult brain, the subventricular zone (SVZ) lining the lateral wall of the lateral ventricles and, the subgranular zone (SGZ) in the dentate gyrus at the hippocampus. Within these neurogenic regions, there are neural stem cells with astrocytic characteristics, which actively respond to the basic fibroblast growth factor (bFGF, FGF2 or FGF-β) by increasing their proliferation, survival and differentiation, both in vivo and in vitro. FGF2 binds to fibroblast growth factor receptors 1 to 4 (FGFR1, FGFR2, FGFR3, FGFR4). Read More

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http://dx.doi.org/10.2174/157436212799278205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279755PMC
January 2012
15 Reads

Neurogenesis in Alzheimer´s disease: a realistic alternative to neuronal degeneration?

Curr Signal Transduct Ther 2011 Sep;6(3):314-319

Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Guadalajara, Jalisco, México 44340.

Neural stem cells (NSC) are cells that have the capacity to generate multiple types of differentiated brain cells. In conditions in which there is a loss of key functional cell groups, such as neurons, inducing or introducing neural stem cells to replace the function of those cells that were lost during the disease has the greatest potential therapeutic applications. Indeed, the achievement of one of the main objectives of various investigations is already on the horizon for some conditions, such as Alzheimer's disease. Read More

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http://dx.doi.org/10.2174/157436211797483949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223938PMC
September 2011
8 Reads

Regulation of neural stem cell in the human SVZ by trophic and morphogenic factors.

Curr Signal Transduct Ther 2011 Sep;6(3):320-326

Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara ; Laboratory of Neuroscience, Facultad de Psicología, Universidad de Colima, Colima, Col, México.

The subventricular zone (SVZ), lining the lateral ventricular system, is the largest germinal region in mammals. In there, neural stem cells express markers related to astoglial lineage that give rise to new neurons and oligodendrocytes In the adult human brain, evidence has also shown that astrocytic cells isolated from the SVZ can generate new neurons and oligodendrocytes. These proliferative cells are strongly controlled by a number of signals and molecules that modulate, activate or repress the cell division, renewal, proliferation and fate of neural stem cells. Read More

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http://dx.doi.org/10.2174/157436211797483958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204663PMC
September 2011
11 Reads

Toll Like Receptors Signaling Pathways as a Target for Therapeutic Interventions.

Curr Signal Transduct Ther 2011 ;6(3):428-440

Vascular Biology Center, Medical College of Georgia, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Medical College of Georgia, USA.

This review summarizes the key role of Toll-Like Receptor (TLRs) molecules for igniting the immune system. Activated by a broad spectrum of pathogens, cytokines or other specific molecules, TLRs trigger innate immune responses. Published data demonstrate that the targeting and suppression of TLRs and TLR-related proteins with particular inhibitors may provide pivotal treatments for patients with cancer, asthma, sepsis, Crohn's disease and thrombosis. Read More

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http://dx.doi.org/10.2174/157436211797483930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376075PMC
January 2011
7 Reads

The Hepatocyte Growth Factor Receptor: Structure, Function and Pharmacological Targeting in Cancer.

Curr Signal Transduct Ther 2011 ;6(2):146-151

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor internalization and degradation. Despite these controls, HGF/Met signaling contributes to oncogenesis and tumor progression in several cancers and promotes aggressive cellular invasiveness that is strongly linked to tumor metastasis. The prevalence of HGF/Met pathway activation in human malignancies has driven rapid growth in cancer drug development programs. Read More

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http://dx.doi.org/10.2174/157436211795659955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156285PMC
January 2011
7 Reads

Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes.

Curr Signal Transduct Ther 2010 Jan;5(1):74-91

Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

The post-translational modification of nucleocytoplasmic proteins with O-linked 2-acetamido-2-deoxy-d-glucopyranose (O-GlcNAc) is a topic of considerable interest and attracts a great deal of research effort. O-GlcNAcylation is a dynamic process which can occur multiple times over the lifetime of a protein, sometimes in a reciprocal relationship with phosphorylation. Several hundred proteins, which are involved in a diverse range of cellular processes, have been identified as being modified with the monosaccharide. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854817PMC
January 2010
4 Reads

The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression.

Curr Signal Transduct Ther 2010 ;5(1):12-24

Complex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA 30602 ; Department of Chemistry, University of Georgia, Athens, GA, USA 30602.

O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins has been shown to be involved in many different cellular processes, such as cell cycle control, nutrient sensing, signal transduction, stress response and transcriptional regulation. Cells have developed complex regulatory systems in order to regulate gene expression appropriately in response to environmental and intracellular cues. Control of eukaryotic gene transcription often involves post-translational modification of a multitude of proteins including transcription factors, basal transcription machinery, and chromatin remodeling complexes to modulate their functions in a variety of manners. Read More

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http://dx.doi.org/10.2174/157436210790226465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255977PMC
January 2010
14 Reads

Protein O-GlcNAcylation: A critical regulator of the cellular response to stress.

Curr Signal Transduct Ther 2010 Jan;5(1):49-59

Department of Medicine, Division of Cardiovascular Disease, Center for Free Radical Biology, Center for Aging and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL.

The post-translational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide ß-N-acetyl-glucosamine (O-GlcNAc) is a highly dynamic and ubiquitous protein modification that plays a critical role in regulating numerous biological processes. Much of our understanding of the mechanisms underlying the role of O-GlcNAc on cellular function has been in the context of chronic disease processes. However, there is increasing evidence that O-GlcNAc levels are increased in response to stress and that acute augmentation of this response is cytoprotective, at least in the short term. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270492PMC
January 2010
5 Reads

The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response.

Curr Signal Transduct Ther 2009 Jan;4(1):46-50

University of Kansas, School of Pharmacy, Department of Pharmacology and Toxicology, Lawrence, KS 66045, USA.

Methionine oxidation by reactive oxygen species and reduction mediated by the methionine sulfoxide reductase (Msr) system may attenuate protein function in signal transduction pathways. This review will focus on two potential protein targets for methionine oxidation involved in signal transduction of the immune response: Ca(2+)/calmodulin-regulated phosphatase calcineurin (Cn) and inhibitor of kappa B-alpha (IkBα). The major known function of Cn is to regulate nuclear localization of the nuclear factor of activated T cells (NFAT), a family of transcription factors during immune stimulus. Read More

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http://dx.doi.org/10.2174/157436209787048748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759190PMC
January 2009
5 Reads

The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis.

Curr Signal Transduct Ther 2009 May;4(2):88-102

Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

High dose oestrogen therapy was used as a treatment for postmenopausal patients with breast cancer from the 1950s until the introduction of the safer antioestrogen, tamoxifen in the 1970s. The anti-tumour mechanism of high dose oestrogen therapy remained unknown. There was no enthusiasm to study these signal transduction pathways as oestrogen therapy has almost completely been eliminated from the treatment paradigm. Read More

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http://dx.doi.org/10.2174/157436209788167484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757321PMC
May 2009
6 Reads

Leptin signaling: A key pathway in immune responses.

Curr Signal Transduct Ther 2009 Jan;4(1):22-30

Department of Medicine, University of California Los Angeles, Los Angeles, California 90095.

Leptin is a hormone whose central role is to regulate endocrine functions and to control energy expenditure. After the discovery that leptin can also have pro-inflammatory effects, several studies have tried to address - at the molecular level - the pathways involved in leptin-induced modulation of the immune functions in normal and pathologic conditions. The signaling events influenced by leptin after its binding to the leptin receptor have been under scrutiny in the past few years, and considerable experimental work has elucidated the consequences of leptin effects on immune cells. Read More

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http://dx.doi.org/10.2174/157436209787048711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747760PMC
January 2009
39 Reads

Mediators of Tyrosine Phosphorylation in Innate Immunity: From Host Defense to Inflammation onto Oncogenesis.

Curr Signal Transduct Ther 2009 May;4(2):76-81

Biosciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

Cells respond to extracellular cues through a variety of receptors on the surface. These signals once transduced across the cell membrane, activate protein tyrosine kinases, which through phosphorylation of substrates on key tyrosine residues, are able to control cellular growth, activation and differentiation pathways. Recent data suggest that protein tyrosine kinases are critical in integrating signals from various cellular receptors, including pathogen detection receptors that mediate the host innate immune response. Read More

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http://dx.doi.org/10.2174/15743620978816750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123156PMC
May 2009
8 Reads

Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity.

Curr Signal Transduct Ther 2008 May;3(2):75-81

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.

Liver X Receptor-α (LXRα, also known as NR1H3) and LXRβ (NR1H2) are members of the nuclear receptor superfamily of ligand-activated transcription factors, a superfamily which includes the more widely known glucocorticoid receptor, estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptors. The LXRs are activated by physiologic sterol ligands (e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931522PMC
May 2008
8 Reads
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