1,125,467 results match your criteria Current Rheumatology Reports[Journal]


The Overview of Methods of Nanoparticle Exposure Assessment.

Methods Mol Biol 2019 ;1894:353-367

Key Laboratory of Occupational Safety and Health, Beijing Municipal Institute of Labour Protection, Beijing, People's Republic of China.

Nanotechnology is now widely used in industry as well as consumer products, such as electrical devices, cosmetics, medicine, and household appliances. In the life cycle of the nano-products, including production, use, and disposal, nanoparticles may be released to the environment. However, there is no current consensus on the best method for evaluating and characterizing nanoparticle exposure. Read More

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January 2019
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Tripartite Network-Based Repurposing Method Using Deep Learning to Compute Similarities for Drug-Target Prediction.

Methods Mol Biol 2019 ;1903:317-328

Betty Irene Moore School of Nursing, University of California Davis, Sacramento, CA, USA.

The drug discovery process is conventionally regarded as resource intensive and complex. Therefore, research effort has been put into a process called drug repositioning with the use of computational methods. Similarity-based methods are common in predicting drug-target association or the interaction between drugs and targets based on various features the drugs and targets have. Read More

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January 2019

A national survey on attitudes and barriers on recycling and environmental sustainability efforts among Canadian anesthesiologists: an opportunity for knowledge translation.

Can J Anaesth 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesia, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Anesthesia-related activities produce 25% of all operating room (OR) waste and contribute to environmental pollution and climate change. The aim of this study was to document Canadian anesthesiologists' current practice, attitudes towards, and perceived barriers regarding recycling of OR waste and environmental sustainability efforts.

Methods: With Research Ethics Board approval, members of the Canadian Anesthesiologists' Society (CAS) completed an online survey consisting of 25 questions assessing current environmentally sustainable practices in anesthesiology and gaps, barriers, and interest in gaining further knowledge on this topic. Read More

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December 2018

Randomized-controlled trial of parent-led exposure to anesthetic mask to prevent child preoperative anxiety.

Can J Anaesth 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology, Perioperative Medicine and Pain Management, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Purpose: To examine the efficacy of parent-directed anesthetic mask exposure and shaping practice to prevent child preoperative anxiety, with a specific focus on timing of exposure.

Methods: This randomized-controlled trial included 110 children ages four to seven years undergoing day surgery dental procedures and their parents. Families were randomly assigned to one of three groups: 1) parent-directed mask exposure/shaping practice at least three times in the week prior to surgery (Group 1); 2) parent-directed mask exposure/shaping practice at least once on the day of surgery (Group 2); 3) no exposure prior to induction (Group 3). Read More

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December 2018

Learning Differential Module Networks Across Multiple Experimental Conditions.

Methods Mol Biol 2019 ;1883:303-321

Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Midlothian, Scotland, UK.

Module network inference is a statistical method to reconstruct gene regulatory networks, which uses probabilistic graphical models to learn modules of coregulated genes and their upstream regulatory programs from genome-wide gene expression and other omics data. Here, we review the basic theory of module network inference, present protocols for common gene regulatory network reconstruction scenarios based on the Lemon-Tree software, and show, using human gene expression data, how the software can also be applied to learn differential module networks across multiple experimental conditions. Read More

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January 2019

Whole-Transcriptome Causal Network Inference with Genomic and Transcriptomic Data.

Methods Mol Biol 2019 ;1883:95-109

Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Midlothian, Scotland, UK.

Reconstruction of causal gene networks can distinguish regulators from targets and reduce false positives by integrating genetic variations. Its recent developments in speed and accuracy have enabled whole-transcriptome causal network inference on a personal computer. Here, we demonstrate this technique with program Findr on 3000 genes from the Geuvadis dataset. Read More

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January 2019

Overview and Evaluation of Recent Methods for Statistical Inference of Gene Regulatory Networks from Time Series Data.

Methods Mol Biol 2019 ;1883:49-94

School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.

A challenging problem in systems biology is the reconstruction of gene regulatory networks from postgenomic data. A variety of reverse engineering methods from machine learning and computational statistics have been proposed in the literature. However, deciding on the best method to adopt for a particular application or data set might be a confusing task. Read More

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January 2019

The content validity of the ANMS GCSI-DD in patients with idiopathic or diabetic gastroparesis.

J Patient Rep Outcomes 2018 Dec 13;2(1):61. Epub 2018 Dec 13.

Temple University Hospital, 3401 N Broad Street, #1003, Philadelphia, PA, 19140, USA.

Background: The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index-Daily Diary (ANMS GCSI-DD) was developed to meet Food and Drug Administration (FDA) recommendations for patient-reported outcome (PRO) endpoints in gastroparesis studies, including therapeutic trials. The current version of the ANMS GCSI-DD contains five items pertaining to nausea, early satiety, post-prandial fullness, upper abdominal pain, and vomiting. The specific aims of this study were to determine if the appropriate symptoms are included in the ANMS GCSI-DD and to assess the content validity in patients with idiopathic (IG) and diabetic gastroparesis (DG). Read More

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December 2018

Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals.

Paediatr Drugs 2018 Dec 13. Epub 2018 Dec 13.

Division of Rheumatology, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Background: Arthropathy of Down syndrome (DA) is largely under-recognized, with an average 2-year delay in diagnosis. Most patients present with polyarthritis, and treatment has historically been challenging.

Objectives: Our objective was to investigate the clinical features and treatment of DA in the largest cohort reported to date. Read More

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December 2018

"Approximate number system" training: A perceptual learning approach.

Atten Percept Psychophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53706, USA.

Recent research suggests that humans perceive quantity using a non-symbolic "number sense." This sense is then thought to provide a foundation for understanding symbolic numbers in formal education. Given this link, there has been interest in the extent to which the approximate number system (ANS) can be improved via dedicated training, as this could provide a route to improving performance in symbolic mathematics. Read More

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December 2018

Nerve grafting for peripheral nerve injuries with extended defect sizes.

Wien Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Artificial and non-artificial nerve grafts are the gold standard in peripheral nerve reconstruction in cases with extensive loss of nerve tissue, particularly where a direct end-to-end suture or an autologous nerve graft is inauspicious. Different materials are marketed and approved by the US Food and Drug Administration (FDA) for peripheral nerve graft reconstruction. The most frequently used materials are collagen and poly(DL-lactide-ε-caprolactone). Read More

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December 2018

A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at ambient temperature.

Mol Divers 2018 Dec 13. Epub 2018 Dec 13.

Chemistry Department, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, 61357-4-3169, Iran.

A facile, efficient and environmentally safe strategy for the synthesis of pyrazolopyranopyrimidines via one-pot, four-component reaction of hydrazine hydrate, barbituric acid, ethyl acetoacetate, and aromatic aldehydes in polyethylene glycol (PEG) as a safe solvent in the absence of catalyst at ambient temperature has been described. The advantages of the present protocol, such as simplicity, mild conditions, high yields of products, straightforward workup procedure, a green and biodegradable reaction medium, make this new process an attractive to current methodologies. Read More

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December 2018

Vaginoplasty and creating labia minora in children with disorders of sex development.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Visceral Surgery, Faculty of Medicine, Children's Hospital Canastel, University of Oran, Oran, Algeria.

Purpose: To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD).

Methods: In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovotesticular DSD. The assessment of the results of this technique of vaginoplasty was undertaken in several stages: (a) The evaluation of the cosmetic result. Read More

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December 2018

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University, Rawalpindi, PK-46300, Pakistan.

Cadmium and mercury are among the most toxic and dangerous environmental pollutants that may cause fatal implications. Vitamin C is an important chain-breaking antioxidant and enzyme co-factor against heavy metals. The objective of the present study was to evaluate the toxicological effects of cadmium chloride, mercuric chloride, and their co-administration on biochemical parameters of blood serum and metal bioaccumulation in kidneys and also to elucidate the protective effect of vitamin C in rabbits against these metals. Read More

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December 2018

Depression, ART Adherence, and Receipt of Case Management Services by Adults with HIV in North Carolina, Medical Monitoring Project, 2009-2013.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

North Carolina Department of Health and Human Services, Division of Public Health, Communicable Disease Branch, Raleigh, NC, 27603, USA.

Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009-2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with "probable current depression" and with 100% ART dose adherence. Read More

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December 2018

Inhibitory Control and Information Processing in ADHD: Comparing the Dual Task and Performance Adjustment Hypotheses.

J Abnorm Child Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Center for Advancement of Youth, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.

Inhibition is a key neurocognitive domain in ADHD that is commonly assessed with the stop-signal task. The stop-signal involves both "go" and "stop" trials; previous research indicates that response times are reliably slower to "go" trials during tasks with vs. without intermittent "stop" trials. Read More

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December 2018
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Undiagnosed cardiac deficits in non-small cell carcinoma patients in the candidate population for anti-cachexia clinical trials.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. Read More

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December 2018

Prevalence of geophagy and knowledge about its health effects among native Sub-Saharan Africa, Caribbean and South America healthy adults living in France.

Eat Weight Disord 2018 Dec 13. Epub 2018 Dec 13.

Service de Médecine Interne et des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Reims, 51092, Reims, France.

Geophagy is widespread among women from Sub-Saharan Africa, South America and the Caribbean and may persist in western countries. This practice may be associated with adverse effects such as anaemia, constipation or intestinal occlusion. We aimed to determine the prevalence of geophagy and the level of knowledge about its health effects among healthy adults originating from these countries and attending a travel medicine and international vaccination consultation in France. Read More

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December 2018

Early Hereditary Diffuse Gastric Cancer (eHDGC) is Characterized by Subtle Genomic Instability and Active DNA Damage Response.

Pathol Oncol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Biomedical Science and Biochemistry, Research School of Biology, ANU College of Medicine, Biology and Environment, Australian National University, P.O. Box: 2601, Canberra, Australia.

Diffuse gastric cancer (DGC) is one of the two primary types of stomach cancer. Carriers of germline mutations in the gene encoding E-cadherin are predisposed to DGC. The primary aim of the present study was to determine if genomic instability is an early event in DGC and how it may lead to disease progression. Read More

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December 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
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Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells.

In Vitro Cell Dev Biol Anim 2018 Dec 13. Epub 2018 Dec 13.

Department of Biophysics, Yeditepe University School of Medicine, Yeditepe University, Istanbul, Turkey.

There has been a controversy in the oncology field about the use of antioxidants along with chemotherapeutics in cancer treatment. This study aimed to investigate the effects of a potent antioxidant (astaxanthin) co-treatment with a promising anti-cancer drug (carbendazim), which is in phase I clinical trials, on MCF-7 breast cancer cell proliferation. MCF-7 cells were treated with carbendazim, astaxanthin, or their combinations and incubated for 24 h. Read More

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December 2018

Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1β release.

Purinergic Signal 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiology and Cell Biology, The Ohio State University, 473 W 12th Avenue, Columbus, OH, 43210, USA.

The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive mature IL-1β by activated immune cells. Microparticle (MP) shedding has also been recently recognized as a manner of cytokine IL-1β release. Read More

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December 2018

Psychometric validation of the work productivity and activity impairment questionnaire in ulcerative colitis: results from a systematic literature review.

J Patient Rep Outcomes 2018 Dec 13;2(1):62. Epub 2018 Dec 13.

Pfizer, 235 42nd Street, New York, NY, 10017, USA.

Patients with ulcerative colitis, a type of inflammatory bowel disease, report negative impacts of disease symptoms on work-related outcomes, including absenteeism and presenteeism. As a way to better understand the impact of this disease and its treatment on work-related outcomes, the current review examines the use of the Work Productivity and Activity Impairment Questionnaire (WPAI), a patient-reported outcomes measure of absenteeism, presenteeism, and impairment in other activities, in studies of patients with ulcerative colitis. This review assesses the measurement properties of the WPAI in this patient population: its reliability, construct validity, ability to detect change, and responsiveness to effective treatments. Read More

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December 2018
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Polyphenol-associated oxidative stress and inflammation in a model of LPS-induced inflammation in glial cells: do we know enough for responsible compounding?

Inflammopharmacology 2018 Dec 13. Epub 2018 Dec 13.

Department Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Cyanidin and chlorogenic acid are polyphenols from plant origin that are present in many common fruits, particularly in berries. To corroborate the protective or detrimental effects of both compounds from a neuro-inflammatory perspective, in vitro experiments were carried out in human astrocytes (U-373). Astrocytes were pre-treated with a range of concentrations of either cyanidin, chlorogenic acid or a combined treatment for a period of 30 min, before exposure to Escherichia coli lipopolysaccharide (LPS) challenge for 23. Read More

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December 2018

A systematic review of current methodology of high resolution pharyngeal manometry with and without impedance.

Eur Arch Otorhinolaryngol 2018 Dec 13. Epub 2018 Dec 13.

Department of Communication Disorders, University of Canterbury, Christchurch, New Zealand.

Purpose: This systematic review appraises and summaries methodology documented in studies using high resolution pharyngeal manometry (HRM) with and without impedance technology (HRIM) in adult populations.

Methods: Four electronic databases CINAHL, EMBASE, MEDLINE, and Cochrane Library were searched up to, and including March 2017. Studies reporting pharyngeal HRM/HRIM for swallowing and/or phonatory assessment, published in peer-reviewed journals in English, German, or Spanish were assessed for the inclusion criteria. Read More

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December 2018

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

Increases in cytosolic Ca induce dynamin- and calcineurin-dependent internalisation of CFTR.

Cell Mol Life Sci 2018 Dec 13. Epub 2018 Dec 13.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previously shown that cigarette smoke (CS) exposure to airway epithelia causes a reduction in plasma membrane CFTR expression which correlated with a decrease in airway surface hydration. The effect of CS on CFTR was dependent on an increase in cytosolic Ca. Read More

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December 2018

[Diagnosis and treatment of immune-related adverse events during checkpoint inhibitor therapy in intensive care medicine].

Med Klin Intensivmed Notfmed 2018 Dec 13. Epub 2018 Dec 13.

Klinik I für Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Background: Due to the use of checkpoint inhibitors, intensive care units will be confronted with an increasing number of patients with immune-related adverse events. A broad spectrum of symptoms and potentially lethal consequences make diagnosis and treatment challenging.

Objectives: Diagnosis and treatment of immune-related adverse events in the treatment with checkpoint inhibitors with a special focus on intensive care units. Read More

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December 2018

[CARs, CRS and neurotoxicity: severe complications after administration of immunotherapy : Essentials for intensivists].

Med Klin Intensivmed Notfmed 2018 Dec 13. Epub 2018 Dec 13.

Klinik I für Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Background: The development of chimeric antigen receptor (CAR) T‑cells has shown promising results in relapsed/refractory B‑cell acute lymphoblastic leukemia/lymphoma (B-ALL) and diffuse large cell B‑cell lymphoma. Complications, especially cytokine release syndrome (CRS) and CAR T‑cell related encephalopathy syndrome (CRES), can be life threatening. The management of both plays a key role in CAR T‑cell therapy. Read More

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December 2018

Anatomical variations of the subscapular pedicle and its terminal branches: an anatomical study and a reappraisal in the light of current surgical approaches.

Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic, Reconstructive and Aesthetic Surgery, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Université Paris Descartes, Paris V, 20 rue Leblanc, 75908, Paris Cedex 15, France.

Purpose: While anatomical variations of the subscapular vessels are frequently encountered during axillary dissection, little is found in the literature. The aim of this cadaveric study was to define arterial and venous anatomical variations and frequencies of the subscapular vascular pedicle and its terminal/afferent vessels in women.

Methods: We performed 80 dissections of the axillary region on forty female formalin-embalmed cadavers. Read More

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December 2018

Robotic versus freehand S2 alar iliac fixation: in-depth technical considerations.

J Spine Surg 2018 Sep;4(3):638-644

Department of Orthopedic Surgery, Norton Leatherman Spine Center, Louisville, KY, USA.

Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. Read More

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September 2018

Chronic obstructive pulmonary disease is an independent predictor for 30-day readmissions following 1- to 2-level posterior lumbar fusions.

J Spine Surg 2018 Sep;4(3):553-559

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality worldwide. Past literature has demonstrated that patients with COPD are at an increased risk of post-operative complications. We assessed the impact of COPD on 30-day outcomes following a 1- to 2-level posterior lumbar fusion (PLF). Read More

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September 2018

Trends in cervical disc arthroplasty and revisions in the Medicare database.

J Spine Surg 2018 Sep;4(3):522-528

East Coast Orthopedics, Pompano, FL, USA.

Background: Due to increased postoperative complications with anterior cervical discectomy and fusion (ACDF), there has been an increasing interest in the use of cervical disc arthroplasty (CDA). Advancements in prosthetic designs and techniques have improved patient reported outcome measurements and minimized revision rates. There is a paucity in the literature regarding recent trends in CDA utilization and revision rates. Read More

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September 2018

Providers' Involvement of Parents, Families, and Family Dynamics in Youth Weight Management Programs.

Glob Pediatr Health 2018 4;5:2333794X18817134. Epub 2018 Dec 4.

East Carolina University, Greenville, NC, USA.

Family-based interventions are the current standard for the treatment of pediatric obesity, yet the details of how providers are involving family members, and the barriers to family involvement, are largely unknown. The objective of this study is to describe how providers in pediatric weight management (PWM) involve family members, identify barriers to family involvement, and how they address challenging family dynamics. A cross-sectional survey was administered to PWM centers/clinics and their providers in the United States and Canada. Read More

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December 2018

Nurses' and Care Workers' Perception of Care Quality in Japanese Long-Term Care Wards: A Qualitative Descriptive Study.

Glob Qual Nurs Res 2018 Jan-Dec;5:2333393618812189. Epub 2018 Nov 30.

University of Tokyo, Tokyo, Japan.

Despite the growing importance of long-term care for older adults, there has been limited attention to its quality assurance issues in Japan. To start planning the initiation of continuous quality improvement in long-term care hospitals, we explored how nurses and care workers themselves perceived current approaches to quality assurance and improvement on their ward. We interviewed 16 licensed nurses and nine care workers, transcribed and analyzed data using qualitative content analysis techniques, and derived six categories: , and . Read More

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November 2018

Lentiviral Vector Purification Using Genetically Encoded Biotin Mimic in Packaging Cell.

Mol Ther Methods Clin Dev 2018 Dec 23;11:155-165. Epub 2018 Oct 23.

UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used are cumbersome and yield low recoveries. We aimed to develop a one-step method to specifically purify LVs, with high yields and reduced levels of impurities, using the biotin-streptavidin system. Read More

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December 2018

Clinical Application of Diagnostic Imaging of Chiari-Like Malformation and Syringomyelia.

Front Vet Sci 2018 28;5:280. Epub 2018 Nov 28.

School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom.

Chiari-like malformation (CM) and syringomyelia (SM) is a frequent diagnosis in predisposed brachycephalic toy breeds since increased availability of MRI. However, the relevance of that MRI diagnosis has been questioned as CM, defined as identification of a cerebellar herniation, is ubiquitous in some breeds and SM can be asymptomatic. This article reviews the current knowledge of neuroanatomical changes in symptomatic CM and SM and diagnostic imaging modalities used for the clinical diagnosis of CM-pain or myelopathy related to SM. Read More

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November 2018
1 Read

Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.

Front Surg 2018 27;5:70. Epub 2018 Nov 27.

Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has presented hope in overcoming the issues involved with current treatment strategies. Read More

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November 2018

Road Map for Nanocrystal Based Infrared Photodetectors.

Front Chem 2018 28;6:575. Epub 2018 Nov 28.

Sorbonne Université, CNRS, Institut des NanoSciences de Paris, INSP, Paris, France.

Infrared (IR) sensors based on epitaxially grown semiconductors face two main challenges which are their prohibitive cost and the difficulty to rise the operating temperature. The quest for alternative technologies which will tackle these two difficulties requires the development of new IR active materials. Over the past decade, significant progresses have been achieved. Read More

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November 2018

Emerging Prognostic Biomarkers in Testicular Germ Cell Tumors: Looking Beyond Established Practice.

Front Oncol 2018 28;8:571. Epub 2018 Nov 28.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.

Testicular germ cell tumors are unique among solid cancers. Historically, this disease was deadly if progressed beyond the stage I. The implementation of cisplatin-based chemotherapy regimens has drastically changed the clinical outcome of metastatic testicular cancer. Read More

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November 2018

A Dual Mode Propulsion System for Small Satellite Applications.

Aerospace (Basel) 2018 2;5(2):52. Epub 2018 May 2.

Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405, USA;

This study focused on the development of a chemical micropropulsion system suitable for primary propulsion and/or attitude control for a nanosatellite. Due to the limitations and expense of current micropropulsion technologies, few nanosatellites with propulsion have been launched to date; however, the availability of such a propulsion system would allow for new nanosatellite mission concepts, such as deep space exploration, maneuvering in low gravity environments and formation flying. This work describes the design of "dual mode" monopropellant/bipropellant microthruster prototype that employs a novel homogeneous catalysis scheme. Read More

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Study of particle number size distributions at Azadi terminal in Tehran, comparing high-traffic and no traffic area.

MethodsX 2018 27;5:1549-1555. Epub 2018 Nov 27.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Vehicle traffic is known as the anthropogenic aerosol source in megacities. Exposure to ambient air pollution, especially particulate matter has become the most environmental risk factor. The main aim of this study is to determine the particle number and their size distribution in Tehran at Azadi terminal (located in the West of Tehran), crossing of Nawab and Azadi streets the area with high traffic, and campus of Tehran University as an area without traffic. Read More

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November 2018

Novel vaccines targeting dendritic cells by coupling allergoids to mannan.

Allergo J Int 2018 18;27(8):256-262. Epub 2018 May 18.

1Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain.

Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems related to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoallergenic molecules. Read More

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Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

Jejunostomy with Enteroenterostomy for Enteral Nutrition in Critically Ill Trauma Patients. A Novel Technique.

Cureus 2018 Oct 9;10(10):e3431. Epub 2018 Oct 9.

General Surgery, Shiraz University of Medical Sciences, Shiraz, IRN.

Purpose The aim of the current study was to report the surgical outcome and complications of jejunostomy with enteroenterostomy for enteral nutrition (EN) in critically ill trauma patients with prolonged nasogastric (NG) nutrition. Methods This cross-sectional study was carried out in a level I trauma center in Shiraz, southern Iran during a one-year period from 2016 to 2017. We included a total number of 30 patients with severe trauma admitted to the intensive care unit (ICU) with more than three months NG nutrition and bowel atrophy. Read More

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October 2018

TGF-β enhances the cytotoxic activity of Vδ2 T cells.

Oncoimmunology 2019 26;8(1):e1522471. Epub 2018 Sep 26.

Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.

TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of induced regulatory T cells (iTreg) but also in the polarization of interleukin-9 (IL-9) producing T helper 9 (Th9) T cells. Human Vδ2 expressing γδ T cells exert potent cytotoxicity towards a variety of solid tumor and leukemia/lymphoma target cells and thus are in the focus of current strategies to develop cell-based immunotherapies. Read More

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September 2018

lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression.

Oncoimmunology 2019 16;8(1):e1518628. Epub 2018 Oct 16.

National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai China.

Hepatocellular carcinoma (HCC) is one type of cancers whose carcinogenesis and progression are closely related to chronic inflammation. Identifying the molecular mechanisms for inflammation-related HCC progression will contribute to improve the efficacy of current therapeutics for HCC patients. Many kinds of epigenetic factors, including long non-coding RNAs (lncRNAs), have been discovered to be important in HCC growth and metastasis. Read More

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October 2018

BRAF and MEK inhibitors differentially affect nivolumab-induced T cell activation by modulating the TCR and AKT signaling pathways.

Oncoimmunology 2019 29;8(1):e1512456. Epub 2018 Oct 29.

Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Immune checkpoint inhibitors (ICIs) such as the anti-PD-1 antibody Nivolumab, achieve remarkable clinical efficacy in patients with late stage cancers. However, only a small subset of patients benefit from this therapy. Numerous clinical trials are underway testing whether combining ICIs with other anti-cancer therapies can increase this response rate. Read More

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October 2018

Warming up the tumor microenvironment in order to enhance immunogenicity.

Oncoimmunology 2019 1;8(1):e1510710. Epub 2018 Oct 1.

Department of Pathology and Immunology, University of Geneva Medical School, Gemeva, Switzerland.

We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses. Read More

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October 2018

Utility of Magnetic Resonance Imaging Brain Epilepsy Protocol in New-Onset Seizures: How is it Different in Developing Countries?

J Clin Imaging Sci 2018 15;8:43. Epub 2018 Nov 15.

Department of Radiodiagnosis, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India.

Introduction: Magnetic resonance imaging (MRI) is the current imaging tool of choice in the investigation of patients with seizures. The advent of high-resolution MRI with a dedicated seizure protocol has significantly increased the chances of identifying a cause, resulting in a positive clinical impact on the management of these patients.

Aims: The aims of this study were to evaluate the diagnostic efficacy of standard MRI, identify whether there is an increase in the diagnostic yield with the addition of dedicated seizure protocol, and compare the diagnostic yields of MRI and electroencephalogram (EEG) individually and in combination. Read More

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November 2018
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