1,487 results match your criteria Current Rheumatology Reports[Journal]


Radiologic Manifestations of Musculoskeletal Sarcoidosis.

Curr Rheumatol Rep 2019 Feb 14;21(3). Epub 2019 Feb 14.

Department of Radiology, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.

Purpose Of Review: The purpose of this review article is to present the spectrum of abnormalities and multi-modality imaging evaluations in patients with musculoskeletal sarcoidosis.

Recent Findings: The articular manifestations of sarcoidosis are difficult to distinguish from those of the other inflammatory and degenerative arthropathies, and the muscular lesions in sarcoidosis are generally clinically silent and therefore often missed. Magnetic resonance imaging has shown these manifestations to be very common in active sarcoidosis, and should thus be included in the screening if musculoskeletal sarcoidosis is suspected. Read More

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http://dx.doi.org/10.1007/s11926-019-0806-0DOI Listing
February 2019

Diagnostic Imaging of Inflammatory Myopathies: New Concepts and a Radiological Approach.

Curr Rheumatol Rep 2019 Feb 14;21(3). Epub 2019 Feb 14.

Department of Radiology, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.

Purpose Of Review: The purpose of this review article is to highlight the current role of diagnostic imaging in the assessment of inflammatory myopathies.

Recent Findings: Recent research demonstrates that imaging plays an important role in evaluating patients with symptoms of an inflammatory myopathy. In general, MRI is the pivotal imaging modality for assessing inflammatory myopathies, revealing precise anatomic details because of changes in the signal intensity of the muscles. Read More

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http://dx.doi.org/10.1007/s11926-019-0807-zDOI Listing
February 2019

Brief Report on the 11th Meeting of the European Forum on Antiphospholipid Antibodies.

Curr Rheumatol Rep 2019 Feb 11;21(2). Epub 2019 Feb 11.

Synapse Research Institute, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s11926-019-0805-1DOI Listing
February 2019

The Invisible Burden of Chronic Fatigue in the Community: a Narrative Review.

Curr Rheumatol Rep 2019 Feb 11;21(2). Epub 2019 Feb 11.

Department of Human Behaviour, School of Psychiatry, University of New South Wales, Level 1 30 Botany Street, UNSW, Sydney, NSW, 2052, Australia.

Purpose Of Review: Unexplained fatigue is commonly reported in the general population, with varying severity. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) sits at the extreme of the fatigue continuum, yet more individuals experience unexplained prolonged fatigue (1-6-month duration) or chronic fatigue (> 6 months) that, although debilitating, does not fulfil ME/CFS criteria. This review examines the empirical literature comparing symptoms for those with prolonged fatigue, chronic fatigue and ME/CFS. Read More

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http://dx.doi.org/10.1007/s11926-019-0804-2DOI Listing
February 2019

SLE-associated risk factors affect DC function.

Authors:
Sun Jung Kim

Curr Rheumatol Rep 2019 Feb 2;21(1). Epub 2019 Feb 2.

Center for Autoimmune and Musculoskeletal Disease, Department of Molecular Medicine, The Feinstein Institute for Medical Research, School of Medicine at Northwell-Hofstra University, 350 Community Drive, Manhasset, NY, 11030, USA.

Purpose Of Review: Identification of function and potential pathogenic mechanisms of SLE risk genes in dendritic cells.

Recent Findings: Functional studies of individual SLE risk factors in dendritic cells were performed, and functional alterations of some risk genes in dendritic cells were observed. Recent studies confirmed the pathogenic function of known risk genes. Read More

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http://dx.doi.org/10.1007/s11926-019-0802-4DOI Listing
February 2019

The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus.

Curr Rheumatol Rep 2019 Jan 23;21(1). Epub 2019 Jan 23.

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, H107, 500 University Drive, Hershey, PA, 17033-0850, USA.

Purpose Of Review: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic associations. Here, we provide an update on recent advancements in validating SLE candidate genes and risk variants identified in genome-wide association studies (GWAS).

Recent Findings: A pairing of computational biology with new and emerging techniques has significantly increased our understanding of SLE associated variants. Read More

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http://dx.doi.org/10.1007/s11926-019-0801-5DOI Listing
January 2019
2 Reads

Genetic Versus Non-genetic Drivers of SLE: Implications of IRF5 Dysregulation in Both Roads Leading to SLE.

Authors:
Betsy J Barnes

Curr Rheumatol Rep 2019 Jan 15;21(1). Epub 2019 Jan 15.

Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Northwell Health, Feinstein Institute for Medical Research, Hofstra-Northwell School of Medicine, 350 Community Dr, Hempstead, NY, 11030, USA.

Purpose Of Review: Systemic lupus erythematosus (SLE) is characterized by a breakdown of immune tolerance, resulting in inflammation and tissue destruction. While the primary causes of SLE are still obscure, the disorder is highly heritable. Genetic risk variants, on their own, are rarely causal or fully explain disease pathogenesis. Read More

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http://link.springer.com/10.1007/s11926-019-0803-3
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http://dx.doi.org/10.1007/s11926-019-0803-3DOI Listing
January 2019
5 Reads

Cell Senescence in Lupus.

Curr Rheumatol Rep 2019 Jan 14;21(2). Epub 2019 Jan 14.

Allergy Immunology Rheumatology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Purpose Of Review: The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of oncogenes, metabolic derangements, and chronic inflammation. Read More

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http://link.springer.com/10.1007/s11926-019-0800-6
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http://dx.doi.org/10.1007/s11926-019-0800-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331499PMC
January 2019
6 Reads

Bone Microdamage in Acute Knee Injury.

Curr Rheumatol Rep 2018 Nov 21;20(12):89. Epub 2018 Nov 21.

Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.

Purpose Of Review: This review summarizes what is known about how bone tissue responds to microdamage, and how this applies to the subchondral region. This has significant relevance to acute joint injury, and is related to the occurrence of bone marrow lesions (BMLs) which are seen by MRI in 80% of acute knee joint injuries. Here, we review what is known about these phenomena (microcracks and BMLs) in the literature and discuss potential mechanisms by which they may be linked. Read More

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http://dx.doi.org/10.1007/s11926-018-0791-8DOI Listing
November 2018
9 Reads

Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review.

Curr Rheumatol Rep 2018 Nov 21;20(12):88. Epub 2018 Nov 21.

Boston Headache Institute, and Director, Clinical Research at Boston PainCare, 85 First Ave, Waltham, MA, 02451, USA.

Purpose Of Review: Osteoarthritis (OA) is the most common form of arthritis that is characterized by loss of articular cartilage and new formation of bone. Pain and functional disability are common features that lead to disability and poor quality of life. This review discusses the current state of knowledge concerning the treatment of pain in OA, with a focus on pharmacological treatments. Read More

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http://dx.doi.org/10.1007/s11926-018-0794-5DOI Listing
November 2018
11 Reads

Autoinflammatory Disease-Associated Vasculitis/Vasculopathy.

Authors:
Mansour Alghamdi

Curr Rheumatol Rep 2018 Nov 17;20(12):87. Epub 2018 Nov 17.

LSU Health Science Center, New Orleans, LA, USA.

Purpose Of Review: Autoinflammatory diseases (AIDs) constitute several disorders that share similar characteristics, clinical features, disease course, and prognosis. They are characterized by the presence of recurrent episodes of unprovoked inflammation due to dysregulated innate immune system in the absence of autoantibodies or infections. AIDs include periodic fever syndromes and other less commonly growing list of syndromes. Read More

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http://dx.doi.org/10.1007/s11926-018-0788-3DOI Listing
November 2018
2 Reads

Gout: Update on Dual-Energy Computed Tomography with Emphasis on Artifact Identification.

Curr Rheumatol Rep 2018 Nov 13;20(12):86. Epub 2018 Nov 13.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose Of Review: Gout is the most common inflammatory arthritis and is increasing in prevalence and incidence in many countries worldwide. Accurate diagnosis is important to direct treatment that may include chronic medication. Burden quantification and treatment monitoring are key in the effective care of patients with gout. Read More

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http://link.springer.com/10.1007/s11926-018-0783-8
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http://dx.doi.org/10.1007/s11926-018-0783-8DOI Listing
November 2018
6 Reads

Anxiety and Mood Disorders in Systemic Lupus Erythematosus: Current Insights and Future Directions.

Curr Rheumatol Rep 2018 Nov 12;20(12):85. Epub 2018 Nov 12.

Department of Internal Medicine, Section of Rheumatology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

Purpose Of Review: Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE, focusing on their etiology, assessment, and management.

Recent Findings: Along with psychosocial factors, there is growing evidence for a bidirectional interaction between inflammatory pathways and SLE-associated anxiety and mood disorders. Read More

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http://link.springer.com/10.1007/s11926-018-0797-2
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http://dx.doi.org/10.1007/s11926-018-0797-2DOI Listing
November 2018
12 Reads

Review of Biosimilar Trials and Data on Etanercept in Rheumatoid Arthritis.

Curr Rheumatol Rep 2018 Nov 9;20(12):84. Epub 2018 Nov 9.

Institute of Ageing and Chronic Disease, University of Liverpool, Aintree University Hospital, Longmoor Lane, Liverpool, L9 7AL, UK.

Purpose Of Review: Etanercept was the first tumour necrosis factor inhibitor approved to treat rheumatoid arthritis (RA) in the United States (US) and Europe. The recent patent expiration of the etanercept originator ENBREL in Europe has facilitated the development of biosimilar products, creating the prospect of reduced treatment costs. In this article, we review the original trials for etanercept in RA to facilitate critical appraisal of biosimilar trial data. Read More

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http://link.springer.com/10.1007/s11926-018-0799-0
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http://dx.doi.org/10.1007/s11926-018-0799-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244902PMC
November 2018
2 Reads

JAK Inhibitors in Rheumatology: Implications for Paediatric Syndromes?

Curr Rheumatol Rep 2018 Nov 8;20(12):83. Epub 2018 Nov 8.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UG12 8TA, UK.

Purpose Of Review: Given the recent increase in the profile and use of Janus kinase inhibitors (JAKinibs) in adult patients with rheumatic diseases, we aimed to review the current evidence accruing for use in paediatric rheumatology patients.

Recent Findings: Significant advances have been made in the management of rheumatic diseases in the past two decades. The introduction of biologic agents in both adults and children has provided significant improvements to patient outcomes and led to better quality of life. Read More

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http://link.springer.com/10.1007/s11926-018-0792-7
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http://dx.doi.org/10.1007/s11926-018-0792-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223710PMC
November 2018
13 Reads

Radiographic Progression in Ankylosing Spondylitis: From Prognostication to Disease Modification.

Curr Rheumatol Rep 2018 Nov 8;20(12):82. Epub 2018 Nov 8.

Division of Rheumatology, Toronto Western Hospital, University of Toronto, 399 Bathurst St, Toronto, ON, M5T2S8, Canada.

Purpose Of Review: Pain, functional limitation, and spinal damage are the three main domains that have significant impact on various aspects of axial spondyloarthritis (axSpA).

Recent Findings: Several randomized controlled trials (RCTs) showed a beneficial effect of non-steroid ant-inflammatory drugs (NSAIDs) and biologic treatments on pain and function. The effect of available treatments on spinal damage is still of interest and is being studied. Read More

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http://link.springer.com/10.1007/s11926-018-0795-4
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http://dx.doi.org/10.1007/s11926-018-0795-4DOI Listing
November 2018
12 Reads

Chronic Periaortitis: an Update.

Curr Rheumatol Rep 2018 Nov 5;20(12):80. Epub 2018 Nov 5.

Nephrology Unit, Parma University Hospital, Parma, Italy.

Purpose Of Review: We aim to review traditional concepts and recent developments on the nosology, pathophysiology, clinical phenotypes and treatment of chronic periaortitis (CP).

Recent Findings: CP is a rare disorder hallmarked by a periaortic fibro-inflammatory tissue. It can present as an isolated disease, but it can also be associated with other autoimmune and fibro-inflammatory lesions (e. Read More

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http://link.springer.com/10.1007/s11926-018-0789-2
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http://dx.doi.org/10.1007/s11926-018-0789-2DOI Listing
November 2018
7 Reads

Cardiovascular and Metabolic Comorbidities in Rheumatoid Arthritis.

Curr Rheumatol Rep 2018 Nov 5;20(12):81. Epub 2018 Nov 5.

Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100, L'Aquila, Italy.

Purpose Of The Review: An increased prevalence of cardiovascular risk factors in rheumatoid arthritis (RA) is reported. The absolute cardiovascular risk in RA patients is higher than in the general population, and although the RA prognosis has gradually improved, premature cardiovascular (CV) mortality remains a matter of fact. The purpose of this review is to shed light on CV and metabolic involvement in RA, with the aim of defining its best management. Read More

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http://link.springer.com/10.1007/s11926-018-0790-9
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http://dx.doi.org/10.1007/s11926-018-0790-9DOI Listing
November 2018
11 Reads

Anti-MDA5 Antibody Spectrum in Western World.

Curr Rheumatol Rep 2018 Oct 31;20(12):78. Epub 2018 Oct 31.

Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Purpose Of Review: Anti-melanoma differentiation-associated gene 5 (anti-MDA5) is a novel and highly specific myositis-associated autoantibody, which defines a unique phenotype among patients with dermatomyositis (DM).

Recent Findings: Anti-MDA5 was originally characterized in Japan in DM patients with hallmark cutaneous features and no proximal muscle weakness and termed clinically amyopathic DM (CADM). Anti-MDA5 has characteristic cutaneous manifestations which include tender palmar papules and cutaneous ulcerations, along with an increased frequency of interstitial lung disease (ILD) that can be rapidly progressive (RPILD) and fatal. Read More

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http://dx.doi.org/10.1007/s11926-018-0798-1DOI Listing
October 2018
3 Reads

Clinical Perspective on Pain and Pain Phenotypes in Osteoarthritis.

Curr Rheumatol Rep 2018 Oct 31;20(12):79. Epub 2018 Oct 31.

Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.

Purpose Of Review: Pain is the most prominent symptom in osteoarthritis. Pain experience is a complex and multifactorial phenomenon. This review, therefore, offers a brief overview of the literature on factors from main pain dimensions and summarizes current evidence for identifying pain phenotypes in knee osteoarthritis. Read More

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http://dx.doi.org/10.1007/s11926-018-0796-3DOI Listing
October 2018
1 Read

Imaging in Psoriatic Arthritis-Insights About Pathogenesis of the Disease.

Curr Rheumatol Rep 2018 Oct 29;20(12):77. Epub 2018 Oct 29.

Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.

Purpose Of Review: Heterogeneity is a hallmark of PsA as musculoskeletal inflammation can affect different tissues including the synovial joint, tendons, entheses, bursa, and bone.

Recent Findings: Relying on clinical examination for investigating underlying mechanisms in PsA is limited by the inherent inaccuracies of examination of the joints, enthesis, and spine. In addition, unlike synovial-centered diseases, histology is hard to obtain for the entheses and spine, limiting the knowledge for different manifestations of PsA. Read More

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http://dx.doi.org/10.1007/s11926-018-0793-6DOI Listing
October 2018
5 Reads

Bridging the Gaps in the Care of Psoriasis and Psoriatic Arthritis: the Role of Combined Clinics.

Curr Rheumatol Rep 2018 Oct 26;20(12):76. Epub 2018 Oct 26.

Department of Medicine, Division of Rheumatology, New York University Langone Health, New York, NY, USA.

Purpose Of Review: Despite a robust therapeutic landscape, significant gaps exist in the quality of care of psoriatic disease. Thus, an improved understanding of the challenges in providing quality care and the implementation of effective strategies to overcome them is needed. In this review, we summarize the burden of psoriatic disease, discuss the challenges in the care of psoriatic patients, and outline how combined dermatology-rheumatology clinics bridge many of these gaps. Read More

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http://link.springer.com/10.1007/s11926-018-0785-6
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http://dx.doi.org/10.1007/s11926-018-0785-6DOI Listing
October 2018
4 Reads

Systematic Review and Meta-analysis: Mindfulness-Based Interventions for Rheumatoid Arthritis.

Curr Rheumatol Rep 2018 Oct 18;20(12):75. Epub 2018 Oct 18.

Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building, Center Tower, Suite 4100, Baltimore, MD, 21224, USA.

Purpose Of Review: To determine the efficacy of mindfulness-based interventions (MBIs) on clinical and patient-reported outcomes in rheumatoid arthritis (RA).

Recent Findings: We identified randomized clinical trials from inception through April 2018 from MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, the Cochrane Library, and hand searches. After screening 338 references, we included five trials with one post-hoc analysis that evaluated MBIs and collectively included 399 participants. Read More

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http://link.springer.com/10.1007/s11926-018-0787-4
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http://dx.doi.org/10.1007/s11926-018-0787-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233984PMC
October 2018
16 Reads

Opportunistic Screening for Osteoporosis Using Computed Tomography: State of the Art and Argument for Paradigm Shift.

Curr Rheumatol Rep 2018 Oct 13;20(12):74. Epub 2018 Oct 13.

University of California Davis School of Medicine, 4860 Y Street, Suite 3100, Sacramento, CA, 95817, USA.

Purpose Of Review: Osteoporosis is disproportionately common in rheumatology patients. For the past three decades, the diagnosis of osteoporosis has benefited from well-established practice guidelines that emphasized the use of dual x-ray absorptiometry (DXA). Despite these guidelines and the wide availability of DXA, approximately two thirds of eligible patients do not undergo testing. Read More

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http://dx.doi.org/10.1007/s11926-018-0784-7DOI Listing
October 2018
1 Read

Use of Physical Activity Monitors in Rheumatic Populations.

Curr Rheumatol Rep 2018 Oct 6;20(12):73. Epub 2018 Oct 6.

Shirley Ryan Ability Laboratory, Center for Rehabilitation Outcomes Research, Chicago, IL, USA.

Purpose Of Review: The purpose of this review paper is to provide an overview of the recent research using physical activity monitors in rheumatic populations including those with osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia.

Recent Findings: Recent research demonstrates increased use of physical activity monitors in these populations, especially in those with osteoarthritis. Results from cross-sectional, longitudinal, and intervention studies highlight that physical activity levels are below recommended guidelines, yet evidence suggests benefits such as improving pain, fatigue, function, and overall well-being. Read More

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http://link.springer.com/10.1007/s11926-018-0786-5
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http://dx.doi.org/10.1007/s11926-018-0786-5DOI Listing
October 2018
8 Reads

Natural Products for Promoting Joint Health and Managing Osteoarthritis.

Curr Rheumatol Rep 2018 Sep 19;20(11):72. Epub 2018 Sep 19.

Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.

Purpose Of Review: Osteoarthritis, the most common joint disease, is associated with substantial medical costs, lost productivity, and reduced quality of life. However, available pharmaceutical treatments have limitations in terms of efficacy and long-term safety.

Recent Findings: In vitro evidence suggests that some natural products may possess anti-inflammatory and anti-oxidative properties and may inhibit the release of key osteoarthritis-related cytokines. Read More

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http://dx.doi.org/10.1007/s11926-018-0782-9DOI Listing
September 2018
6 Reads

Novel Concepts in Psoriatic Arthritis Management: Can We Treat to Target?

Curr Rheumatol Rep 2018 Sep 18;20(11):71. Epub 2018 Sep 18.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK.

Purpose Of Review: Psoriatic arthritis (PsA) is a chronic inflammatory spondyloarthritis that can cause progressive joint damage and irreversible disability. Advances in modern therapies, now mean a target of remission is an achievable goal in PsA. There is strong and consistent evidence that a treat-to-target (T2T) approach to PsA management results in better patient outcomes; however, the practicalities of incorporating this strategy into routine clinical practice remain a challenge. Read More

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http://dx.doi.org/10.1007/s11926-018-0781-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153572PMC
September 2018
6 Reads

Differentiating Disease Flare From Infection: A Common Problem in Rheumatology. Do 18F-FDG PET/CT Scans and Novel Biomarkers Hold The Answer?

Curr Rheumatol Rep 2018 Sep 17;20(11):70. Epub 2018 Sep 17.

Department of Inflammation Biology, King's College London, New Hunt's House, Great Maze Pond, London, SE1 1UL, UK.

Purpose Of Review: Fever is common within rheumatology but it is often challenging to identify its source. To do so correctly is paramount in patients with an underlying inflammatory condition receiving immunosuppressive therapy. This review article looks at the available evidence and merits of both 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans and new proposed biomarkers in determining the cause of fever within rheumatology. Read More

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http://link.springer.com/10.1007/s11926-018-0779-4
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http://dx.doi.org/10.1007/s11926-018-0779-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153569PMC
September 2018
3 Reads

Periprosthetic Joint Infection in Patients with Inflammatory Joint Disease: Prevention and Diagnosis.

Curr Rheumatol Rep 2018 Sep 10;20(11):68. Epub 2018 Sep 10.

Department of Academic Training, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA.

Purpose Of Review: Periprosthetic joint infection (PJI) is a devastating complication that can occur following total joint arthroplasty (TJA), causing significant morbidity and often requiring revision surgery. This goal of this manuscript is to review the current evidence for the prevention and diagnosis of PJI in patients with inflammatory arthritis.

Recent Findings: Patients with inflammatory arthritis have a higher risk of PJI after TJA; however, there are several preventive, diagnostic, and therapeutic measures that can be optimized to lower the burden of PJI in this population. Read More

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http://link.springer.com/10.1007/s11926-018-0777-6
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http://dx.doi.org/10.1007/s11926-018-0777-6DOI Listing
September 2018
23 Reads

Primary Thrombosis Prophylaxis in Persistently Antiphospholipid Antibody-Positive Individuals: Where Do We Stand in 2018?

Curr Rheumatol Rep 2018 Sep 10;20(11):66. Epub 2018 Sep 10.

Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, 535 E 70th Street, New York, NY, 10021, USA.

Purpose Of Review: To update our previous literature review and management recommendations on risk stratification and primary thrombosis prophylaxis in persistently antiphospholipid antibody (aPL)-positive individuals.

Recent Findings: The estimated annual thrombosis incident rate (ATIR) among aPL-positive individuals with or without systemic autoimmune disease (SAIDx) is 0 to 5.3%, probably very low (< 1%/year) in those with no other SAIDx and thrombosis risk factors. Read More

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http://link.springer.com/10.1007/s11926-018-0775-8
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http://dx.doi.org/10.1007/s11926-018-0775-8DOI Listing
September 2018
13 Reads

Hypophosphatasia: From Diagnosis to Treatment.

Curr Rheumatol Rep 2018 Sep 10;20(11):69. Epub 2018 Sep 10.

1st Medical Department, Hanusch Hospital, Heinrich Collin-Str. 30, 1140, Vienna, Austria.

Purpose Of Review: Hypophosphatasia (HPP) is a rare genetic disorder caused by mutations of the ALPL gene. ALPL encodes the tissue-non-specific isoenzyme of alkaline phosphatase (TNSALP). Consequently, bone mineralization is decreased leading to fractures, arthralgia, and extra-skeletal manifestations including tissue calcification, respiratory failure, and neurological complications. Read More

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http://dx.doi.org/10.1007/s11926-018-0778-5DOI Listing
September 2018
13 Reads

Evaluating the Current Literature on Treatments Containing Adipose-Derived Stem Cells for Osteoarthritis: a Progress Update.

Curr Rheumatol Rep 2018 Sep 10;20(11):67. Epub 2018 Sep 10.

University of Cambridge, Cambridge, UK.

Purpose Of Review: Recent studies have investigated the effect of treatments containing adipose-derived mesenchymal stem cells (ADMSCs) on human osteoarthritis. These have mostly used biologic adjuvants which may influence results. Thus, the purpose of this systematic review is to evaluate the current literature on these treatments when used in isolation. Read More

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http://dx.doi.org/10.1007/s11926-018-0776-7DOI Listing
September 2018
21 Reads
2.454 Impact Factor

Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.

Curr Rheumatol Rep 2018 Sep 6;20(10):65. Epub 2018 Sep 6.

Perlmutter Cancer Center, NYU School of Medicine, New York, NY, 10016, USA.

Purpose Of Review: With the advent of cancer immunotherapy and immune checkpoint inhibitors, patients with malignancies can now achieve durable remissions for conditions previously described as terminal. However, immune-related adverse events (irAEs) associated with cancer immunotherapy have become an anticipated consequence of enhanced T cell activation. Through an extensive literature review, we assess the most recent clinical and basic research data concerning immune checkpoint blockade and describe the spectrum of associated irAEs as well as their management. Read More

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http://link.springer.com/10.1007/s11926-018-0770-0
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http://dx.doi.org/10.1007/s11926-018-0770-0DOI Listing
September 2018
17 Reads

A Practical Approach to the Use of Conventional Synthetic, Biologic and Targeted Synthetic Disease Modifying Anti-Rheumatic Drugs for the Treatment of Inflammatory Arthritis in Patients with a History of Malignancy.

Curr Rheumatol Rep 2018 Sep 1;20(10):64. Epub 2018 Sep 1.

Redcliffe Hospital, Redcliffe, Queensland, Australia.

Purpose Of Review: Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) have been used in the treatment of inflammatory arthritis (IA) for many years. More recently, biologic (bDMARDs) and targeted synthetic (tsDMARDs) DMARDs have further improved treatment. Due to increased patient longevity and effective oncology treatment, rheumatologists often encounter patients with IA and previous malignancy. Read More

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http://link.springer.com/10.1007/s11926-018-0774-9
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http://dx.doi.org/10.1007/s11926-018-0774-9DOI Listing
September 2018
12 Reads

Brief Report on the 10th Meeting of the European Forum on Antiphospholipid Antibodies.

Curr Rheumatol Rep 2018 Aug 21;20(10):63. Epub 2018 Aug 21.

Vascular Medicine Division and Regional Competence Center for Rare Vascular and Systemic Autoimmune Diseases, CHRU de Nancy, F-54000, Nancy, France.

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http://dx.doi.org/10.1007/s11926-018-0767-8DOI Listing
August 2018
1 Read

Role of Infectious Diseases in the Antiphospholipid Syndrome (Including Its Catastrophic Variant).

Curr Rheumatol Rep 2018 Aug 20;20(10):62. Epub 2018 Aug 20.

Department of Autoimmune Diseases, Hospital Clinic, Villarroel, 170, 08036, Barcelona, Catalonia, Spain.

Purpose Of Review: The antiphospholipid syndrome (APS) is characterized by the development of thrombotic events and pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). An infectious etiology for this syndrome has been postulated. The present review is aimed to summarize recent evidence about the role of infections and vaccines in the pathogenesis of the APS (including its catastrophic variant). Read More

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http://dx.doi.org/10.1007/s11926-018-0773-xDOI Listing
August 2018
14 Reads

Rheumatic Manifestations of Haemoglobinopathies.

Authors:
Michael Hughes

Curr Rheumatol Rep 2018 Aug 14;20(10):61. Epub 2018 Aug 14.

Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, S10 2JF, Sheffield, UK.

Purpose Of The Review: To provide a clinically useful literature review on the rheumatic manifestations of haemoglobinopathies, critically analysing the literature from the past 5 years.

Recent Findings: There are limited new data to guide the management of rheumatic manifestations of haemoglobinopathies. Data further confirm the wide spectrum of potential rheumatic/MSK involvement in haemoglobinopathies, which poses both a diagnostic and therapeutic challenge. Read More

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http://dx.doi.org/10.1007/s11926-018-0768-7DOI Listing
August 2018
4 Reads

Induction Therapy for Lupus Nephritis: the Highlights.

Curr Rheumatol Rep 2018 Aug 14;20(10):60. Epub 2018 Aug 14.

Division of Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Purpose Of Review: Lupus nephritis is a frequent complication of systemic lupus erythematosus and is more common and severe in children. This is a disease of the immune system characterized by T cell, B cell, and complement activation, as well as immune complex formation and deposition. The introduction of steroids and later cyclophosphamide transformed lupus nephritis from a fatal to a treatable condition. Read More

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http://dx.doi.org/10.1007/s11926-018-0766-9DOI Listing
August 2018
15 Reads

Obstetric Anti-phospholipid Syndrome: State of the Art.

Curr Rheumatol Rep 2018 Aug 13;20(10):59. Epub 2018 Aug 13.

Rheumatology and Clinical Immunology Unit and Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy.

Purpose Of Review: This review focuses on new pathogenesis and clinical-therapeutic aspects of obstetric anti-phospholipid syndrome (ob-APS) in the last 5 years.

Recent Findings: The pathogenesis of ob-APS is multifactorial, including placental infarctions, infiltration of inflammatory cells that cause acute and chronic inflammation, leading to uncontrolled inflammation and poor pregnancy outcomes. A preconception counseling and a patient-tailored treatment are fundamental to improve maternal and fetal outcomes. Read More

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http://link.springer.com/10.1007/s11926-018-0772-y
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http://dx.doi.org/10.1007/s11926-018-0772-yDOI Listing
August 2018
6 Reads

Review of Biosimilar Trials and Data on Adalimumab in Rheumatoid Arthritis.

Curr Rheumatol Rep 2018 Aug 9;20(10):57. Epub 2018 Aug 9.

Department of Musculoskeletal Biology I, Clinical Sciences Centre, Institute of Ageing and Chronic Disease, University of Liverpool, Aintree University Hospital, Longmoor Lane, Liverpool, L9 7AL, UK.

Purpose Of Review: Adalimumab is one of the top-selling drugs worldwide. Its imminent patent expiration has seen the emergence of numerous biosimilar agents. In this article, we recap the evidence from bio-originator trials in rheumatoid arthritis (RA) to provide context for a critical review of biosimilar trial data. Read More

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http://link.springer.com/10.1007/s11926-018-0769-6
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http://dx.doi.org/10.1007/s11926-018-0769-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097048PMC
August 2018
6 Reads

The History of Psoriatic Arthritis (PsA): From Moll and Wright to Pathway-Specific Therapy.

Authors:
Luis R Espinoza

Curr Rheumatol Rep 2018 Aug 9;20(10):58. Epub 2018 Aug 9.

Section of Rheumatology, LSU Health Sciences Center, New Orleans, LA, 70112, USA.

Purpose Of Review: Psoriatic arthritis is a distinct disorder, separate from rheumatoid arthritis, and first recognized in a thirteenth century Saxon skeleton. It was, however, the monumental work of Verna Wright in the 1950s that led to the acceptance by the American Rheumatism Association (now American College of Rheumatology) in 1964 as a distinct entity. Wright's work provided the framework for a better understanding of the pathogenic mechanisms operating on this condition, and eventually led to the development of targeted therapy that has proven to be more effective and safe than conventional therapy. Read More

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http://dx.doi.org/10.1007/s11926-018-0771-zDOI Listing
August 2018
3 Reads

Potential Pathogenic Role of Anti-Signal Recognition Protein and Anti-3-hydroxy-3-methylglutaryl-CoA Reductase Antibodies in Immune-Mediated Necrotizing Myopathies.

Curr Rheumatol Rep 2018 Aug 3;20(9):56. Epub 2018 Aug 3.

UPMC Univ Paris 06, INSERM UMRS_974, Center of Research in Myology, AP-HP, Department of Internal Medicine & Clinical Immunology, DHU I2B, Pitié-Salpêtrière Hospital, Sorbonne Université, F-75013, Paris, France.

Purpose Of Review: This review provides an overview of the potential pathogenic roles of anti-SRP and anti-HMGCR in IMNM over the past 5 years.

Recent Findings: Idiopathic inflammatory myopathies (IIM) are a group of acquired autoimmune disorders that mainly affect the skeletal muscle tissue. Classification criteria of IIM are comprised of polymyositis, dermatomyositis, inclusion body myositis and immune-mediated necrotizing myopathies. Read More

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http://link.springer.com/10.1007/s11926-018-0763-z
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http://dx.doi.org/10.1007/s11926-018-0763-zDOI Listing
August 2018
11 Reads

Artemisinins-a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review.

Curr Rheumatol Rep 2018 Jul 28;20(9):55. Epub 2018 Jul 28.

Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center/Tufts University School of Medicine, Box 406, Boston, MA, 02111, USA.

Purpose Of Review: Systemic lupus erythematosus (SLE) is a complex, potentially fatal autoimmune disease with no complete cure. Current treatments for SLE are limited by suboptimal efficacy and increased risk of infections and malignancies, and cannot meet the clinical demands of patients with SLE. Artemisinin and its derivatives (artemisinins), a new class of anti-malarial drugs, have recently been reported to have an immunosuppressive effect on lupus patients. Read More

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http://dx.doi.org/10.1007/s11926-018-0764-yDOI Listing
July 2018
2 Reads

Current Concepts and Future Directions of Minimally Invasive Treatment for Knee Pain.

Curr Rheumatol Rep 2018 Jul 23;20(9):54. Epub 2018 Jul 23.

Vascular and Interventional Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Purpose Of Review: The purpose of this paper is to review the percutaneous interventions available for the treatment of osteoarthrosis of the knee that address pain and prolong the time to arthroplasty.

Recent Findings: Corticosteroid injection and viscosupplementation have been the most studied, but there is still no consensus about their value. Thermal nerve ablation, including both radiofrequency ablation and cryoneurolysis, is a promising new modality of therapy that may increase in clinical use given current data showing favorable outcomes. Read More

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http://dx.doi.org/10.1007/s11926-018-0765-xDOI Listing
July 2018
14 Reads

Proteomics in Chronic Arthritis-Will We Finally Have Useful Biomarkers?

Curr Rheumatol Rep 2018 Jul 14;20(9):53. Epub 2018 Jul 14.

Department of Paediatric Rheumatology and Immunology, University of Muenster, Domagkstraße 3, 48149, Muenster, Germany.

Purpose Of Review: Current technical advances enable the assessment of the complex changes in body fluid proteomes and thus allow for the discovery of biomarker signatures rather than just following differences of a single marker. In this review, we aim to summarize current approaches to discover and evaluate multi-biomarker panels for improved monitoring of chronic arthritis disease activity.

Recent Findings: Mass spectrometry and affinity proteomic methodologies have been used to identify biomarker panels in synovial fluid, serum, plasma, or urine of pediatric and adult chronic arthritis patients. Read More

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http://dx.doi.org/10.1007/s11926-018-0762-0DOI Listing
July 2018
16 Reads
2.454 Impact Factor

Update on Inclusion Body Myositis.

Curr Rheumatol Rep 2018 Jun 28;20(8):52. Epub 2018 Jun 28.

Neuromuscular Division, Department of Neurology and the Institute for Neurological Discoveries, The University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 2012, Kansas City, KS, 66160, USA.

Purpose Of Review: While sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease after age 50, the pathogenesis of this disease is still poorly understood. In this review, we discuss our current state of knowledge in sIBM and provide an update on our current understanding of its pathophysiology and management.

Recent Findings: Lines of evidence in support of an inflammatory pathogenesis include inflammatory infiltrates in the target organ, NFκB activation, cytokine response, MHC I upregulation, and cN1A antibody. Read More

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http://dx.doi.org/10.1007/s11926-018-0755-zDOI Listing
June 2018
10 Reads

Expression and Metabolomic Profiling in Axial Spondyloarthritis.

Curr Rheumatol Rep 2018 Jun 27;20(8):51. Epub 2018 Jun 27.

Faculty of Medicine and Genetics, Memorial University of Newfoundland, 154 LeMarchant Rd, St. John's, Newfoundland and Labrador, A1C 5B8, Canada.

Purpose Of Review: The purpose of this review is to highlight recent evidence with respect to expression and metabolomic profiling in axial spondyloarthritis (axSpA) that included ankylosing spondylitis (AS).

Recent Findings: AxSpA is not only characterized by the strongest genetic contribution for any complex rheumatic disease but is also influenced by environmental and immunological factors. Large-scale association-based studies have identified over 100 genetic variants contributing to 30% of the genetic risk of ankylosing spondylitis. Read More

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http://dx.doi.org/10.1007/s11926-018-0756-yDOI Listing
June 2018
3 Reads

Preclinical Rheumatoid Arthritis and Rheumatoid Arthritis Prevention.

Authors:
Kevin D Deane

Curr Rheumatol Rep 2018 Jun 26;20(8):50. Epub 2018 Jun 26.

Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court, Mail Stop B-115, Aurora, CO, 80045, USA.

Purpose Of Review: This review is to provide an update on the current understanding of rheumatoid arthritis (RA) development related to disease development prior to the onset clinically apparent synovitis and opportunities for disease prevention.

Recent Findings: A growing number of studies have demonstrated that serum elevations of autoantibodies rheumatoid factor and antibodies to citrullinated protein/peptide antigens (ACPA) are highly predictive of future development of IA/RA. This has underpinned the development of several prevention trials in RA. Read More

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http://dx.doi.org/10.1007/s11926-018-0754-0DOI Listing
June 2018
2 Reads

Update on the Gastrointestinal Microbiome in Systemic Sclerosis.

Curr Rheumatol Rep 2018 Jun 25;20(8):49. Epub 2018 Jun 25.

Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Ste 32-59, Los Angeles, CA, 90095, USA.

Purpose Of Review: Accumulating evidence suggests that gut microbiota affect the development and function of the immune system and may play a role in the pathogenesis of autoimmune diseases. The purpose of this review is to summarize recent studies reporting gastrointestinal microbiota aberrations associated with the systemic sclerosis disease state.

Recent Findings: The studies described herein have identified common changes in gut microbial composition. Read More

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http://dx.doi.org/10.1007/s11926-018-0758-9DOI Listing
June 2018
2 Reads

Optimizing Rheumatoid Arthritis Patients for Surgery.

Curr Rheumatol Rep 2018 Jun 25;20(8):48. Epub 2018 Jun 25.

Department of Medicine/Perioperative Medicine, Hospital for Special Surgery, Weill Cornell Medicine, 535 East 70th Street, 6th Floor, New York, NY, 10021, USA.

Purpose Of Review: The purpose of this review is to guide providers on how best to optimize the health of patients with rheumatoid arthritis (RA) planning surgery, to reduce risk and complications and achieve the best outcomes.

Recent Findings: The American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) have issued a recent guideline on perioperative management of antirheumatic medications in patients with RA. Patients with RA will continue to need surgery. Read More

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http://dx.doi.org/10.1007/s11926-018-0757-xDOI Listing
June 2018
2 Reads