254 results match your criteria Current Radiopharmaceuticals [Journal]


[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471012666181212101244DOI Listing
December 2018

Utility Of Molecular Imaging With 2-Deoxy-2-[Fluorine-18] Fluoro-D-Glucose Positron Emission Tomography (18f-Fdg Pet) For Small Cell Lung Cancer (Sclc): A Radiation Oncology Perspective.

Curr Radiopharm 2018 Nov 20. Epub 2018 Nov 20.

Department of Radiation Oncology; University of Health Sciences, Gulhane Medical Faculty, Ankara. Turkey.

Background And Objective: Although accounting for a relatively small proportion of all lung cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy (RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy. There has been considerable progress in RT of SCLC thanks to improved imaging techniques leading to accurate target localization for precise delivery of RT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471012666181120162434DOI Listing
November 2018
2 Reads

Biochemical and histopathological evaluation of the radioprotective effects of melatonin against Gamma ray-induced skin damage in rats.

Curr Radiopharm 2018 Nov 20. Epub 2018 Nov 20.

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran. Iran.

Background: Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471012666181120163250DOI Listing
November 2018
1 Read

The Evolving Clinical Role of Actinium-225 and Bismuth-213 for Targeted Alpha Therapy (TAT) - Production, Radiopharmaceutical Development and Clinical Applications.

Curr Radiopharm 2018 ;11(3):154-155

Emeritus, Prorgam Manager, Corporate Fellow Nuclear Medicine Program Isotope Development Group Nuclear Security and Isotope Technology Division Oak Ridge National Laboratory (ORNL) P. O. Box 2008, 1 Bethel Valley Road Oak Ridge, TN, 37831-6229, United States.

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165289/article
Publisher Site
http://dx.doi.org/10.2174/187447101103180911115600DOI Listing
January 2018
3 Reads

Synthesis of [18F]FAZA using Nosyl and Iodo Precursors for Nucleophilic Radiofluorination.

Curr Radiopharm 2018 Oct 18. Epub 2018 Oct 18.

Department of Oncology, University of Alberta, and Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta. Canada.

Background: 1-α-D-(5-Deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA) is manufactured by nucleophilic radiofluorination of 1-α-D-(2',3'-di-O-acetyl-5'-O-toluenesulfonylarabinofuranosyl)-2-nitroimidazole (DiAcTosAZA) and alkaline deprotection to afford [18F]FAZA. High yields (>60%) under optimized conditions frequently revert to low yields (<20%) in large scale, automated syntheses. Competing side reactions and concomitant complex reaction mixtures contribute to substantial loss of product during HPLC clean-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666181019105947DOI Listing
October 2018

Determination of gamma camera's calibration factors for quantitation of diagnostic radionuclides in simultaneous scattering and attenuation correction.

Curr Radiopharm 2018 Sep 13. Epub 2018 Sep 13.

Isfahan University of Medical Sciences, P.O. Box: 8174673461, Isfahan. Iran.

Objective: The characterization of cancerous tissue and bone metastasis can be distinguished by the accurate assessment of accumulated uptake and activity from different radioisotopes. The various parameters and phenomena such as calibration factor, Compton scattering, attenuation and penetration are influenced intrinsic this quantity, and the qualification of images as well.

Methods: The camera calibration factor (CF) translates reconstructed count map into absolute activity map, is determined by both planar and tomographic scans using different phantom geometries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180914095222DOI Listing
September 2018

Evaluating the radioprotective effect of curcumin on rat's heart tissues.

Curr Radiopharm 2018 Aug 30. Epub 2018 Aug 30.

Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (International Campus), Tehran. Iran.

Background: Heart injury is one of the most important concerns after exposure to a high dose of radiation in chest cancer radiotherapy or whole body exposure to a radiation disaster. Studies have proposed that increased level of inflammatory and pro-fibrotic cytokines following radiotherapy or radiation events play a key role in the development of several side effects such as cardiovascular disorders. In current study, we aimed to evaluate the expression of IL-4 and IL-13 cytokines as well as signaling pathways such as IL4Ra1, IL13Ra2, Duox1 and Duox2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180831101459DOI Listing
August 2018
1 Read

Dosimetry and Toxicity Studies of the Novel Sulfonamide Derivative of Sulforhodamine 101([18F]SRF101) at a Preclinical Level

Curr Radiopharm 2018 08 30. Epub 2018 Aug 30.

Uruguayan Centre of Molecular Imaging (CUDIM), Radiopharmacy Department, Montevideo. Uruguay.

Background: The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo.

Objective: The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180830145304DOI Listing

Choline-PET/CT in the differential diagnosis between cystic glioblastoma and intraparenchymal hemorrhage.

Curr Radiopharm 2018 Aug 17. Epub 2018 Aug 17.

Neurorehabilitation Unit, Department of Rehabilitation, Fondazione Istituto G. Giglio, Cefalu. Italy.

Objective: Glioblastoma multiforme (GBM) represents the most common and malignant glioma, accounting for 45%-50% of all gliomas . The median survival time for patients with glioblastoma is only 12-15 months after surgical, chemioterapic and radiotherapic treatment; a correct diagnosis is naturally fundamental to establish a rapid and correct therapy. Non-invasive imaging plays a pivotal role in each phase of the diagnostic workup of patients with suspected for diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180817122427DOI Listing
August 2018
9 Reads

Stability Study of [18F]Fludeoxyglucose and [18F]Fluorocholine in Different Medical Devices for Intravenous Administration.

Curr Radiopharm 2018 ;11(2):138-146

Pharmacy Department, Radiopharmacy Unit, Hospices Civils de Lyon, Lyon Sud Hospital, 165 Chemin du Grand Revoyet F-69310 Pierre-Benite, France.

Objective: The present study had determine the impact of prolonged storage in a cartridge or syringe on the quality of the [18F]-radiopharmaceuticals used in our center [18F]fludeoxyglucose and [18F]fluorocholine). [18F]-radiopharmaceuticals registered as ready-to-use drugs are prepared in multidose flasks. When the change of packaging must be made extemporaneously for the preparation of patient unit doses in a syringe or cartridge, this is under the responsibility of radiopharmacists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180703165639DOI Listing
October 2018
7 Reads

Final Outcome of 223Ra-therapy and the Role of 18F-fluoride-PET in Response Evaluation in Metastatic Castration-resistant Prostate Cancer-A Single Institution Experience.

Curr Radiopharm 2018 ;11(2):147-152

Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.

Background: 223Ra was the first therapeutic alpha-emitting radionuclide registered for clinical practice. This radionuclide is targeting actively bone-forming cells, and it is approved for treating metastatic skeletal disease in prostate cancer. 18F-PET is used to detect skeletal metastatic disease based on osteoblastic activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180629145030DOI Listing
October 2018
10 Reads

Evaluation of [Ac]Ac-DOTA for α-Therapy of Bone Metastases.

Curr Radiopharm 2018 ;11(3):223-230

Institute of Nuclear Chemistry, Johannes Gutenberg University, Mainz, Germany.

Background: Conjugates of bisphosphonates with macrocyclic chelators possess high potential in bone targeted radionuclide imaging and therapy. DOTAZOL, zoledronic acid conjugated to DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), demonstrated promising results in vivo in small animals as well as in first patient applications using 68Ga for diagnosis via PET and the lowenergy β-emitter 177Lu for therapy of painful bone metastases. In consideration of the fact that targeted α-therapy probably offers various advantages over the use of β--emitters, the 225Ac-labelled derivative [225Ac]Ac-DOTAZOL was synthesized and evaluated in vivo. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/162704/article
Publisher Site
http://dx.doi.org/10.2174/1874471011666180604083911DOI Listing
January 2018
7 Reads

Development and Evaluation of Liquid and Solid Lipid Based Drug Delivery Systems Containing Technetium-99m-Radiolabeled Alendronate Sodium.

Curr Radiopharm 2018 ;11(2):100-108

Ege University, Faculty of Pharmacy, Department of Radiopharmacy, 35100 Bornova, Izmir, Turkey.

Objective: The purpose of this study was to develop lipid-water based drug delivery system of Alendronate Sodium (ALD) in liquid and solid form obtained by using spray drying method and compare these two forms with radioactive cell culture studies.

Methods: This study included the development of liquid and solid form obtained by spray drying method, radiolabelling of ALD with 99mTc, preparation of formulations containing 99mTc -ALD and evaluation of their permeability with Caco-2 cell. The liquid formulations have been developed by using various surfactants, co-surfactants, oil and water phases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180529111914DOI Listing
October 2018
15 Reads

Radioprotective Effect of Cerium Oxide Nanoparticles Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes.

Curr Radiopharm 2018 ;11(2):109-115

Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Ionizing radiation induces DNA damage on normal cell results in apoptosis and cell deaths.

Objectives: The radioprotective effects of cerium oxide nanoparticles (CNPs) on genotoxicity, apoptosis and necrosis induced by Ionizing Radiation (IR) in human healthy lymphocytes as highly radiosensitive cells were investigated.

Materials And Methods: Lymphocytes were prepared from three volunteers and then treated with CNPs at different concentrations and exposed to IR at dose 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180528095203DOI Listing
October 2018
2 Reads

PET Evaluation of Late Cerebral Effect in Advanced Radiation Therapy Techniques for Cranial Base Tumors.

Curr Radiopharm 2018 ;11(2):86-91

Vita-Salute San Raffaele University and Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.

Background And Objective: Even though the benefits of radiation therapy are well established, it is important to recognize the broad spectrum of radiation-induced changes, particularly in the central nervous system. The possible damage to the brain parenchyma may have clinical consequences and in particular cognitive impairment might be one of the major complications of radiotherapy. To date, no studies have investigated the effects of focal radiation therapy on brain structure and function together with the assessment of their clinical outcomes at a long follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180525134301DOI Listing
October 2018

Clinical Studies with Bismuth-213 and Actinium-225 for Hematologic Malignancies.

Authors:
Joseph G Jurcic

Curr Radiopharm 2018 ;11(3):192-199

Division of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York- Presbyterian Hospital, Herbert Irving Comprehensive Cancer Center, New York, NY, United States.

Objectives: Due to the shorter range and higher linear energy transfer of α-particles compared to β-particles, targeted α-particle therapy may produce more efficient tumor killing while sparing neighboring healthy cells. We will review the clinical studies using α-particle therapy for Acute Myeloid Leukemia (AML).

Methods: A series of clinical trials were conducted to assess the safety, feasibility, and anti-leukemic effects of lintuzumab, an anti-CD33 humanized monoclonal antibody, labeled with the α-emitters bismuth- 213 (213Bi) and actinium-225 (225Ac). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180525102814DOI Listing
January 2018

NorthStar Perspectives for Actinium-225 Production at Commercial Scale.

Authors:
James T Harvey

Curr Radiopharm 2018 ;11(3):180-191

NorthStar Medical Technologies, LLC, Beloit, WI, United States.

Objective: Actinium-225, and its daughter Bismuth-213, have great promise in Alpha Immuno Therapy (AIT) for treatment of various disease modalities. Unfortunately, current production levels of actinium-225 do not support broad use of either actinium-225 or bismuth-213 in development or use for disease treatment. Further, the current cost per millicurie is much too high to be sustainable long term. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180515123848DOI Listing
January 2018
6 Reads

Automated Synthesis of 68Ga-DOTA-TOC with a Cationic Purification System: Evaluation of Methodological and Technical Aspects in Routine Preparations.

Curr Radiopharm 2018 ;11(2):130-137

Nuclear Medicine Unit, University Hospital, Ferrara (FE), Italy.

Background And Objective: Gallium-68 is a PET isotope available in each nuclear medicine departments, even those not equipped with a cyclotron, since it is easily obtained by eluting compact and transportable generator system. The preparation of Ga-68 DOTA-labeled compounds is performed by remotely controlled automated systems developed in order to ensure production efficiency, reproducibility of the results, fast reaction time, to facilitate the synthesis and minimize the radiation exposure. Many automatic synthesis systems are available on the radiopharmaceutical market, however, they requires some technical adaptations for routine use. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/161984/article
Publisher Site
http://dx.doi.org/10.2174/1874471011666180509101420DOI Listing
October 2018
16 Reads

An Overview of Targeted Alpha Therapy with Actinium and Bismuth.

Curr Radiopharm 2018 ;11(3):200-208

European Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany.

Background: Recent reports of the remarkable therapeutic efficacy of 225Ac-labeled PSMA- 617 for therapy of metastatic castration-resistant prostate cancer have underlined the clinical potential of targeted alpha therapy.

Objective And Conclusion: This review describes methods for the production of 225Ac and its daughter nuclide 213Bi and summarizes the current clinical experience with both alpha emitters with particular focus on recent studies of targeted alpha therapy of bladder cancer, brain tumors, neuroendocrine tumors and prostate cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180502104524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237921PMC
January 2018
9 Reads

Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides.

Curr Radiopharm 2018 ;11(3):209-214

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States.

Background: Radiopharmaceutical therapy is a cancer treatment modality by which radiation is delivered directly to targeted tumor cells or to their microenvironment. This makes it possible to deliver highly potent alpha-particle radiation. The short-range and highly potent nature of alpha-particles require a dosimetry methodology that considers microscale distributions of the alpha-emitting agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180426130058DOI Listing
January 2018
1 Read

Evaluation of Free and Chelated Accelerator-produced Actinium- 225 - Radiation Dosimetry and Toxicity Results.

Curr Radiopharm 2018 ;11(3):215-222

College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Rd, Health Sciences Bld, Box 3D01-11, Saskatoon, Saskatchewan, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.

Background And Objective: The demand for the alpha-emitting radionuclide Actinium-225 (225Ac) for use in radionuclide therapy is growing. Producing 225Ac using high energy linear accelerators, cyclotrons or photoinduction could increase its supply. One potential problem with accelerator produced 225Ac using Thorium-232 targets is the presence in final product of 0. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/161485/article
Publisher Site
http://dx.doi.org/10.2174/1874471011666180423120707DOI Listing
January 2018
6 Reads

Motion Management in PET/CT: Technological Solutions.

Curr Radiopharm 2018 ;11(2):79-85

Nuclear Medicine Department, San Gerardo Hospital, ASST-Monza, Italy.

Background And Objective: Motion due to patient's breathing can introduce heavy bias in PET/CT, both in image quality and quantitation. This paper is a review of the main technical solutions available to manage movement in PET/CT studies: a) Respiratory Gated (RG), b) Motion Free (MF), c) End Expiration (EE), d) Banana Artefact Management (BAM) and e) Data Driven Gating (DDG).

Methods: The most diffused solutions (RG, MF and EE) are based on LIST mode acquisition of a PET Field of View (4D FOV), centered on the anatomical region of interest; to link PET data not only to time and to spatial position but also to the corresponding breathing phase, the synchronized acquisition of the patient's breathing curve is performed by an external tracking device. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180419150440DOI Listing
October 2018
8 Reads

The Production of Ac-225.

Authors:
Jonathan W Engle

Curr Radiopharm 2018 ;11(3):173-179

Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, United States.

Background: The radionuclide 225Ac and its daughter 213Bi are among the most interesting alpha emitters being evaluated for incorporation into targeted therapeutic vectors. Global supply of 225Ac is presently insufficient to meet anticipated clinical demand, but the deficiency has been targeted by many research and development efforts, privately and publicly funded. From more than a decade of these endeavors, no single production technology has emerged as a complete solution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180418141357DOI Listing
January 2018
3 Reads

Ga-68 Nanoparticles and Ultra-small Nanoparticle: Next Generation of PET Radiopharmaceuticals?

Curr Radiopharm 2018 ;11(2):123-129

Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil.

Background And Objective: The future of medicine relies on the capability to forecast the future and in the development of new drugs. The same rationale is applied to radiopharmacy. In this direction the development of nano-radiopharmaceuticals represents the most effective glance of the future. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180418110206DOI Listing
October 2018
6 Reads

Development of Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences.

Curr Radiopharm 2018 ;11(3):156-172

Life Sciences Division, TRIUMF, Vancouver BC, Canada.

Background: The development of radiopharmaceuticals containing 225Ac for targeted alpha therapy is an active area of academic and commercial research worldwide.

Objectives: Despite promising results from recent clinical trials, 225Ac-radiopharmaceutical development still faces significant challenges that must be overcome to realize the widespread clinical use of 225Ac. Some of these challenges include the limited availability of the isotope, the challenging chemistry required to isolate 225Ac from any co-produced isotopes, and the need for stable targeting systems with high radiolabeling yields. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180416161908DOI Listing
January 2018
8 Reads

Preparation and Dosimetry Evaluation of a Carrier- Free 90Y Labeled DOTMP as a Promising Agent for Bone Marrow Ablation.

Curr Radiopharm 2018 ;11(2):116-122

Nuclear Science and Technology Research Institute (NSTRI), P.O. Box: 11365-8486, Tehran, Iran.

Background And Objective: Skeletal uptake of 90Y-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonate (DOTMP) is used to deliver high doses of this radiopharmaceutical to the bone marrow.

Methods: In this research, carrier-free (c.f. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180412165722DOI Listing
October 2018
4 Reads

Modeling of a Cyclotron Target for the Production of 11C with Geant4.

Curr Radiopharm 2018 ;11(2):92-99

Medical Physics Unit, University Hospital "S. Orsola-Malpighi", Via Massarenti 9, 40138, Bologna, Italy.

Background: In medical cyclotron facilities, 11C is produced according to the 14N(p,α)11C reaction and widely employed in studies of prostate and brain cancers by Positron Emission Tomography. It is known from literature that the 11C-target assembly shows a reduction in efficiency during time, meaning a decrease of activity produced at the end of bombardment. This effect might depend on aspects which are still not completely known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180412170219DOI Listing
October 2018
3 Reads

Preface.

Curr Radiopharm 2018 ;11(1):2-3

Department of Biocatalysis and Isotope Chemistry Almac Sciences Almac House Craigavon, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/187447101101180404093206DOI Listing
August 2018
3 Reads

Preliminary Human Radiation Dose Estimates of PET Renal Agents, Para-F-Fluorohippuric Acid and Ortho-I-Iodohippuric Acid from Rat Biodistribution Data.

Curr Radiopharm 2018 ;11(1):58-63

Department of Pharmaceutical Sciences, College of Pharmacy, the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.

Background: Para-18F-fluorohippuric acid (18F-PFH) and ortho-124I-iodohippuric acid (124IOIH) were recently identified as potential radiotracers suitable for conducting renography using positron emission tomography (PET). The aim of this work was to estimate preliminary human-equivalent internal radiation dose of 18F-PFH and 124I-OIH using the biodistribution data reported in healthy rats. The results were compared with the absorbed dose data of technetium-99m-mercaptoacetyltriglycine (99mTc- MAG3) as documented in the International Commission on Radiological Protection (ICRP) publication 80. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180212123534DOI Listing
August 2018
12 Reads

Quantification of Radiation Exposure of Non-Dominant Index for the Surgeon Performing Sentinel Lymph-Node Removal Procedure.

Curr Radiopharm 2018 ;11(1):64-68

Department of Nuclear Medicine, Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.

Background: Sentinel lymph-node scintigraphy is a useful method for accurate staging of different tumors and a helpful tool in personalized therapy for oncological patients. The radiation exposure for surgical staff has been a concern since the sentinel lymph-node detection method was developed.

Objective: The objective of the study was to determine and quantify the exposure to radiation of the non-dominant index for the surgeon performing sentinel lymph-node removal and to determine, if there is an irradiation risk imposed during the surgical procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666180206165744DOI Listing
August 2018
11 Reads

Mechanisms of Radiation Bystander and Non-Targeted Effects: Implications to Radiation Carcinogenesis and Radiotherapy.

Curr Radiopharm 2018 ;11(1):34-45

Scientific Research Department, Uniformed Services University of Health Sciences (USUHS), Armed Forces Radiobiology Research Institute (AFRRI), Bethesda, MD, 20889-5603, United States.

Background: Knowledge of radiobiology is of paramount importance to be able to grasp and have an in-depth understanding of the consequences of ionizing radiation. One of the most important effects of this physical stressor's interaction to targeted and non-targeted cells, tissues and organs is on the late effects on the development of primary and secondary cancers. Thus, an in-depth understanding of the mechanisms of radiation carcinogenesis remains to be elucidated, and some studies have demonstrated or proposed a role of non-targeted effect in excess risk of cancer incidence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666171229123130DOI Listing
August 2018
9 Reads

Review: The Role of Radiolabeled DOTA-Conjugated Peptides for Imaging and Treatment of Childhood Neuroblastoma.

Curr Radiopharm 2018 ;11(1):14-21

The Hospital for Sick Children, Division of Pediatric Hematology Oncology, University of Toronto, Toronto, Canada.

Background: Childhood neuroblastoma is a heterogenous disease with varied clinical presentation and biology requiring different approaches to investigation and management. Metaiodobenzylguanidine (MIBG) is an essential component of metastatic staging for neuroblastoma and has been used as a treatment strategy for relapsed and refractory neuroblastoma. However, as 10% of children with neuroblastoma will have 123I-MIBG non-avid imaging and up to 60% with relapsed and refractory neuroblastoma will require further treatment with 131I-MIBG, alternative radioisotopes have been investigated for imaging and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666171215093112DOI Listing
August 2018
15 Reads

Radiopharmaceuticals Labelled with Copper Radionuclides: Clinical Results in Human Beings.

Curr Radiopharm 2018 ;11(1):22-33

Sapienza University of Rome, Department of Radiology, Oncology and Human Pathology, Nuclear Medicine Unit, Rome, Italy.

Background: Positron emission tomography (PET) is an instrumental diagnostic modality developed around the positron-emitting radioisotopes of biologically important elements such as carbon, oxygen and nitrogen (11C, 15O, 13N). Among longer-lived PET radionuclides, 18F is by far the most commonly used radiotracer, extensively used for tumour imaging with FDG ([18F]-fluorodeoxyglucose) and also frequently investigated in the development of novel radiopharmaceuticals. Many other positron- emitting radionuclides with higher atomic numbers and longer half-lives have been investigated for both imaging and therapeutic purposes, including the halogens (124I, 120I, 76Br) and a number of metal radionuclides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666171211161851DOI Listing
August 2018
11 Reads

PET Radiopharmaceuticals in Brazil and Belarus: Economic Comparison Using the Case of FDG.

Curr Radiopharm 2018 ;11(1):69-72

Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rua Helio de Almeida, 75, Ilha do Fundao, 21941906, Rio de Janeiro, Brazil.

Background: The production of radiopharmaceuticals, especially the PET ones, is a complex combination of economic and social factors. Despite the social aspects, that are essential, the economic issue must be considered and play an important parameter for the implementation and maintenance of producer centers around the world, with especial regards for countries which face economic crisis and/or belongs to aegis of under development countries.

Objectives: In order to evaluate this scenario with carried out this study, comparing a well-established producer center in Brazil and a new on in Belarus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471011666171211164111DOI Listing
August 2018
9 Reads

18F-FAZA PET/CT in the Preoperative Evaluation of NSCLC: Comparison with 18F-FDG and Immunohistochemistry.

Curr Radiopharm 2018 ;11(1):50-57

Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Purpose: To assess the capability of 18F-FAZA PET/CT in identifying intratumoral hypoxic areas in early and locally advanced non-small cell lung cancer (NSCLC) patients and to compare 18FFAZA PET/CT with 18F-FDG PET/CT and histopathological biomarkers and to investigate whether the assessment of tumour to blood (T/B) and tumour to muscle (T/M) ratios provide comparable information regarding the hypoxic fractions of the tumour.

Materials And Methods: Seven patients with NSCLC were prospectively enrolled (3 men, 4 women; median age: 71 years; range 63-80). All patients underwent to 18F-FDG PET/CT and 18F-FAZA PET/CT before surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666171108162319DOI Listing
August 2018
42 Reads

PET/CT With Ga-PSMA in Prostate Cancer: Radiopharmaceutical Background and Clinical Implications.

Curr Radiopharm 2018 ;11(1):4-13

Nuclear Medicine Department, S. Andrea Hospital, La Spezia, Italy.

Background And Objective: In the last twenty years, positron emission tomography / computed tomography (PET/CT) with radiolabeled choline, represented the most powerful imaging modality for prostate cancer (PCa). However, the low positive detection rate of the technique for PSA < 1 ng/ml prompted the development of other tracers for imaging PCa.

Methods: We performed a critical review of 68Ga-PSMA, a receptor ligand tracer, which has been identified as the most promising radiopharmaceutical for imaging PCa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666171101121803DOI Listing
August 2018
16 Reads

Italian Tailored Assessment of Lung Indeterminate Accidental Nodule by Proposing a Segmental Pet/Computed Tomography (s-Pet/Ct): Rationale And Study Design of a Retrospective, Multicenter Trial.

Curr Radiopharm 2018 ;11(1):46-49

University of Naples Federico II, Naples, Italy.

Background: The Italian Tailored Assessment of Lung Indeterminate Accidental Nodule (ITALIAN) is a retrospective, multicenter trial designed to compare the diagnostic information provided by segmental positron emission tomography (PET)/computed tomography (CT) (s-PET/CT) with those of whole body (wb)-PET/CT in patients with single pulmonary nodules (SPN). This report describes the details and implications of the ITALIAN trial design.

Methods And Results: Between September 2016 and May 2017, 502 consecutive patients (302 men, mean age 67±12 years) with SPN undergoing 18F-fluorodeoxyglucose (FDG) PET/CT were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666171002113700DOI Listing
August 2018
16 Reads

Synthesis of [18F]2B-SRF101: A Sulfonamide Derivative of the Fluorescent Dye Sulforhodamine 101.

Curr Radiopharm 2017 Nov;10(3):212-220

Uruguayan Centre of Molecular Imaging (CUDIM) Radiopharmacy Department, Montevideo. Uruguay.

Background: The red fluorescent dye Sulforhodamine 101 (SR101) has been used in neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this work is to label SR101 with positron emission radionuclides, in order to provide a radiotracer to study its biological behavior. This is the first attempt to label SR101 by [18F], using a chemical derivatization via a sulfonamidelinker and a commercially available platform. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/155947/article
Publisher Site
http://dx.doi.org/10.2174/1874471010666170928112853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740491PMC
November 2017
12 Reads

Editorial Review 2017.

Curr Radiopharm 2017;10(1):2-5

Second University of Naples Naples. Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/187447101001170309162941DOI Listing
August 2018
6 Reads

11C-Choline PET/CT based Helical Tomotherapy as Treatment Approach for Bone Metastases in Recurrent Prostate Cancer Patients.

Curr Radiopharm 2017 Nov;10(3):195-202

Department of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: To evaluate the efficacy of 11C-choline PET/CT (CHO-PET/CT) based helical tomotherapy (HTT) as a therapeutic approach for bone metastases in recurrent prostate cancer (PCa) patients.

Methods: This retrospective study includes 20 PCa patients (median age: 67; range: 51-80 years) presenting biochemical relapse after primary treatment who underwent CHO-PET/CT based HTT on positive bone metastases from December 2007 to June 2014. The effectiveness of HTT has been assessed with biochemical response at 3/6/12 months, biochemical relapse free survival (bRFS) and overall survival (OS) at 2 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170919162517DOI Listing
November 2017
17 Reads

Radio-localization of Non-Palpable Breast Lesions Under Ultrasonographic Guidance: Current Status and Future Perspectives.

Curr Radiopharm 2017 Nov;10(3):178-183

Sapienza University of Rome, Department of Radiology, Oncology and Human Pathology, Nuclear Medicine Unit, Rome, Italy.

Background: Due to the spread of mammographic screening programs, a constant increase of clinically-occult breast cancer diagnosis has been registered. A correct approach to nonpalpable breast lesions requires an accurate intra-operative localization in order to achieve a complete surgical resection. The aim of this paper is to describe the state of the art of the US-guided procedures such as Radio-guided Occult Lesion Localization (ROLL) and Radio-guided Seed Localization (RSL) in comparison to the most widely adopted Wire-Guided Localization (WGL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170908122531DOI Listing
November 2017
31 Reads

PET/MR Tomographs: A Review with Technical, Radiochemical and Clinical Perspectives.

Curr Radiopharm 2017 Nov;10(3):184-194

Nuclear Medicine Department, S. Andrea Hospital, La Spezia, Italy.

Background And Objective: In the last decade, an increasing number of positron emission tomography / magnetic resonance (PET/MR) tomographs were installed and many clinical studies were performed in the neurological field.

Methods: Although PET/MR has many favorable properties to support the application in brain imaging, attenuation correction, and therefore accurate quantification, is a problem that still requires optimal solution.

Results: In this review we have summarized the three main methods that are currently used to correct attenuation in PET/MR, namely atlas- or template-based methods, segmentation-based methods, and reconstruction-based methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170816125051DOI Listing
November 2017
6 Reads

Bone Imaging in Metastatic Castration-resistant Prostate Cancer; Where do we Stand.

Curr Radiopharm 2017 Nov;10(3):171-177

The Pennine Acute Hospitals, NHS Trust - Urology, Manchester, United Kingdom.

Background And Objectives: We are witnessing an era of increased clinical interest in metastatic castration-resistant prostate cancer, both in terms of treatment and also in terms of imaging options. This surge of interest is attributed to the recent developments in treatments for metastatic prostate cancer that are able to confer a significant survival advantage. We are therefore, anticipating an increase in the number of patients that we need to treat at this disease stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170816125907DOI Listing
November 2017
12 Reads

The Role of Radiopharmaceuticals in Amiodarone-Induced Thyroid Pathology.

Curr Radiopharm 2017 Nov;10(3):146-154

Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.

Background And Objective: The use of amiodarone for the treatment of ventricular and supraventricular dysrhythmias brings in organism an increased amount of iodine, interfering with thyroid function. If the treatment needs to be interrupted, iodine remains at abnormal levels for months or even years. The aim of the study was to review the literature regarding the optimal tests for early diagnostic and to analyze the role of nuclear medicine tests in the differential and correct assessment of the amiodarone-induced thyroid pathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170816125402DOI Listing
November 2017
12 Reads

Personalized & Precision Medicine in Cancer: A Theranostic Approach.

Curr Radiopharm 2017 Nov;10(3):166-170

Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India.

Background And Objectives: There are many challenges in the execution of targeted therapy in cancer due to tumor heterogeneity between individuals. In case of solid tumors this is one of the reasons as to why genomic analysis from single tumor biopsy specimens underestimate the mutational burdens in such heterogeneous tumors thus contributing to treatment failure and drug resistance. Molecular characteristics redefine tumor classification for molecular targeted therapies ensuring the best patient specific therapies with better specificity and cost effective ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170728094008DOI Listing
November 2017
5 Reads

Automated One-pot Radiosynthesis of [11C]S-adenosyl Methionine.

Curr Radiopharm 2017 Nov;10(3):203-211

Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay.

Background: Glycine N-methyltransferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM or AdoMet) as substrate. SAM is involved in a great variety of biochemical processes, including transmethylation reactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170718171441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740492PMC
November 2017
11 Reads

Chemical Consequences of Radioactive Decay and their Biological Implications.

Authors:
Onofre T DeJesus

Curr Radiopharm 2017 Nov;10(3):155-165

School of Medicine and Public Health, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research B1147, 1111 Highland Avenue, Madison WI 53705, United States.

The chemical effects of radioactive decay arise from (1) transmutation, (2) formation of charged daughter nuclei, (3) recoil of the daughter nuclei, (4) electron "shakeoff" phenomenon and (5) vacancy cascade in decays via electron capture and internal conversion. This review aims to reiterate what has been known for a long time regarding the chemical consequences of radioactive decay and gives a historical perspective to the observations that led to their elucidation. The energetics of the recoil process in each decay mode is discussed in relation to the chemical bond between the decaying nucleus and the parent molecule. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170714163359DOI Listing
November 2017
9 Reads

Radiochemical Evaluation and In Vitro Assessment of the Targeting Ability of a Novel 99mTc-HYNIC-RGD for U87MG Human Brain Cancer Cells.

Curr Radiopharm 2017 Aug;10(2):139-144

Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari. Iran.

Background: Labeled RGD peptide that specifically targets ανβ3 integrin has great potential for the early diagnosis of malignant tumors.αvβ3 integrin receptors appear specifically more on the surface of glioblastoma (malignant glioma) cells rather than normal cells.

Objective: The aim of this study was to identify a novel RGD that can be radiolabeled with99mTc with in vitro assessment of its targeting ability for U87MG human brain cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170706164016DOI Listing
August 2017
20 Reads

Effect of Treatment with Caspofungin on the Diagnosis of Fungal Infections by Gamma Scintigraphy.

Curr Radiopharm 2017 Aug;10(2):131-138

Cátedra de Radioquímica, Departamento Estrella Campos, Facultad de Química, Universidad de la República-Uruguay, Montevideo. Uruguay.

The aim of this work was to assess the influence of treatment with U-Caspofungin, on the quality of diagnostic scintigraphic images of induced lesions in nude mice undergoing both bacterial and fungal infections and to determine the level of specificity of 99mTc-tricarbonyl-Caspofungin to discriminate between fungal or bacterial infections. In vitro studies on the behaviour of the 99mTc-tricarbonyl-Caspofungin complex binding percentage at different yeast concentrations of Candida albicans or Staphyolococcus aureus were determined. The incubation was performed with and without U-Caspofungin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1874471010666170703125709DOI Listing
August 2017
7 Reads