7,773 results match your criteria Current Pharmaceutical Design[Journal]


Organ-on-A-Chip for Drug Screening and Personalized Medicine.

Curr Pharm Des 2019 ;24(45):5352-5353

Department of Chemical Engineering Feng Chia University Taichung 40724, Taiwan.

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http://dx.doi.org/10.2174/138161282445190416155151DOI Listing
January 2019

Update on Mechanisms of Adaptive Resistance to Immune Check Point Blockers in Malignancies: A Short Commentary.

Curr Pharm Des 2019 ;24(45):5349-5351

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari, Bari, Italy.

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http://dx.doi.org/10.2174/138161282445190416154917DOI Listing
January 2019
1 Read

Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.

Curr Pharm Des 2019 Apr 10. Epub 2019 Apr 10.

Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems, University of Salamanca, Salamanca. Spain.

Background: Major depression is a frequent psychiatric disease. A third of depressive patients remain treatment-resistant; thus, it is urgent to find novel antidepressant drugs.

Objective: In major depression, we up-date in several brain areas the neural networks involved and the alterations of neurotransmitters and neuropeptides. Read More

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http://dx.doi.org/10.2174/1381612825666190410165243DOI Listing

Preventive role of Resveratrol against inflammatory cytokines and related diseases

Curr Pharm Des 2019 04 10. Epub 2019 Apr 10.

Department of Pharmaceutical Sciences, School of Life Sciences, North South University, Dhaka-1229, Bangladesh.

Background: Immunity is the ultimate barrier between foreign stimuli and a host cell. Unwanted immune responses can threaten the host cells and may eventually damage a vital organ. Overproduction of inflammatory cytokines may also lead to autoimmune diseases. Read More

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http://dx.doi.org/10.2174/1381612825666190410153307DOI Listing
April 2019
3 Reads
3.452 Impact Factor

Hyperuricemia and Cardiovascular Disease.

Curr Pharm Des 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmacy, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang. China.

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. Read More

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http://dx.doi.org/10.2174/1381612825666190408122557DOI Listing
April 2019
2 Reads

Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia.

Curr Pharm Des 2019 Apr 5. Epub 2019 Apr 5.

Department of Internal Medicine; Division of Pharmacology and Vascular Medicine, Erasmus MC University Medical Center, Rotterdam. Netherlands.

Background: Adequate development of the placenta is essential for optimal pregnancy outcome. Pre-eclampsia (PE) is increasingly recognized to be a consequence of placental dysfunction and can cause serious maternal and fetal complications during pregnancy. Furthermore, PE increases the risk of neonatal problems and has been shown to be a risk factor for cardiovascular disease of the mother later in life. Read More

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http://dx.doi.org/10.2174/1381612825666190405145228DOI Listing
April 2019
2 Reads

Inhibitors of DNA methylation and histone deacetylation as epigenetically active drugs for anticancer therapy.

Curr Pharm Des 2019 Apr 5. Epub 2019 Apr 5.

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow 125315. Russian Federation.

Gene expression is regulated and tightly controlled by epigenetic mechanisms. Alterations of these mechanisms are frequently observed in various diseases, in particular, in various types of cancer. Malignant transformation is caused by the impairment of the mechanisms of cell differentiation and cell cycle control associated with epigenetic changes. Read More

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http://dx.doi.org/10.2174/1381612825666190405144026DOI Listing
April 2019
2 Reads

JAK inhibition: the most promising agents in the IBD pipeline?

Curr Pharm Des 2019 Apr 5. Epub 2019 Apr 5.

Inflammatory Bowel Disease Group, Institut d'Investigacions Biomètiques August Pi I Sunyer (IDIBAPS), Barcelona. Spain.

Under current therapeutic algorithms, half of the patients with moderate-severe ulcerative colitis or Crohn's disease fail in achieving a sustained remission. New drugs with different mechanisms of action are needed. After two decades of new drug avenues in inflammatory bowel disease dominated by the development of monoclonal antibodies, in recent years we are witnessing promising developments of small molecules for these conditions. Read More

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http://dx.doi.org/10.2174/1381612825666190405141410DOI Listing
April 2019
4 Reads

Synthetic optimization of ellipticine and antitumor activity of novel hexacyclic derivatives of ellipticine.

Curr Pharm Des 2019 04 4. Epub 2019 Apr 4.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050. China.

A high-yield synthetic procedure of ellipticine has been optimized, and the total yield was up to 50% without silica gel column chromatography. Novel hexacyclic ellipticine derivatives were synthesized by coupling ellipticine with o-aminobenzoic acid. Their cytotoxicities against HCT116, MGC803, HT29 and MCF-7 tumor cells were evaluated. Read More

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http://dx.doi.org/10.2174/1381612825666190404122650DOI Listing
April 2019
4 Reads

The regulation roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer.

Curr Pharm Des 2019 Apr 4. Epub 2019 Apr 4.

Department of Biochemistry, China Three Gorges University, Yichang 443002. China.

Background: Ovarian cancer is the highest malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most paints are found late.), relapse, and resistance to existing chemotherapy drugs. Read More

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http://dx.doi.org/10.2174/1381612825666190404122154DOI Listing
April 2019
5 Reads

Limitations and Opportunities in Topical Drug Delivery: Interaction between Silica Nanoparticles and Skin Barrier.

Curr Pharm Des 2019 Apr 4. Epub 2019 Apr 4.

Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile. Chile.

The first limiting barrier for the transport in the skin is the stratum corneum; different strategies have been developed to overcome this barrier, including chemical enhancers. However, these penetration enhancers have limitations, including toxic adverse effects. In this context, research into nanomaterials has provided new tools to increase the residence time of drugs by generating a reservoir, increasing the specificity of drugs and reducing their adverse effects, and improving the penetration of drugs that are difficult to formulate. Read More

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http://dx.doi.org/10.2174/1381612825666190404121507DOI Listing
April 2019
2 Reads

Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review.

Curr Pharm Des 2019 Apr 2. Epub 2019 Apr 2.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad. Iran.

Ethnopharmacological Relevance: The genus Curcuma, which is the most important source of curcumin, has been widely used in different traditional medicines. Various species of Curcuma have long been used for several purposes such as healing wounds, liver disorders, jaundice and also as a blood purifier.

Aim Of The Study: This review focused on the ethnopharmacological uses and phytochemical aspects of Curcuma. Read More

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http://dx.doi.org/10.2174/1381612825666190402163940DOI Listing
April 2019
3.452 Impact Factor

Laponite-based nanomaterials for biomedical applications: A review.

Curr Pharm Des 2019 Apr 2. Epub 2019 Apr 2.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science, Donghua University. China.

Laponite based nanomaterials (LBNMs) are highly diverse regarding their mechanical, chemical, and structural properties, coupled with shape, size, mass, biodegradability and biocompatibility. These ubiquitous properties of LBNMs make them an appropriate material for extensive applications. These have enormous potential for effective and targeted drug delivery comprised of numerous biodegradable materials which results into enhanced bioavailability. Read More

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http://dx.doi.org/10.2174/1381612825666190402165845DOI Listing
April 2019
1 Read

Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments.

Curr Pharm Des 2019 Apr 3. Epub 2019 Apr 3.

Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples. Italy.

Background: Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in a variety of diseases such as inflammatory diseases, Alzheimer's disease and cancer.

Methods: This review reports the recent advancement in the research of SphKs inhibitors. Read More

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http://dx.doi.org/10.2174/1381612825666190404115424DOI Listing
April 2019
1 Read

GDF-15 is a multifunctional modulator and potential therapeutic target in cancer.

Curr Pharm Des 2019 Apr 1. Epub 2019 Apr 1.

Department of Thoracic surgeryThe First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011. China.

Various pathological processes are associated with the aberrant expression and function of cytokines, especially those belonging to the transforming growth factor-β (TGF-β) family. Nevertheless, the functions of members of the TGF-β family in cancer progression and therapy are still uncertain. Growth differentiation factor- 15, which exists in intracellular and extracellular forms, is classified as a divergent member of the TGF-β superfamily. Read More

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http://dx.doi.org/10.2174/1381612825666190402101143DOI Listing
April 2019
2 Reads

Depression and treatment with effective herbs.

Curr Pharm Des 2019 Apr 1. Epub 2019 Apr 1.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord. Iran.

Depression is one of the common psychiatric diseases and one of the main causes of disability worldwide. In spite of certain developments in this field, chemical and synthetic drugs used for treatment of depression disrupt the treatment process due to the numerous side effects and high cost. Today, the goal of using a potential method for treating depression involves the use of medicinal and phytochemical plants, which has many therapeutic benefits. Read More

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http://dx.doi.org/10.2174/1381612825666190402105803DOI Listing
April 2019
1 Read

Cellular and molecular basis of osteoblastic and vascular niches in the processes of hematopoiesis and bone remodeling (A short review of modern views).

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Basic Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad. Russian Federation.

In evolutionary processes, human bone marrow has formed as an organ depot of various types of cells that arise from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Vital HSC activity is controlled through molecular interactions with the niche microenvironment. The review describes current views on the formation of key molecular and cellular components of the HSC niche, which ensure maintenance of homeostasis in stem cell niches, obtained from studies of their role in regulating the proliferation and differentiation of HSCs, including the physiological, reparative and pathological remodeling of bone tissue. Read More

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http://dx.doi.org/10.2174/1381612825666190329153626DOI Listing
March 2019
2 Reads

A novel DKL [LKlLKlLlkKLLkLL-NH2; K is Lys, L is Leu, k is D-Lys, l is D-Leu] modified probe for positron emission tomography imaging.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Department of Nuclear Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032. China.

Peptides containing the asparagine-glycine-arginine (NGR) motif can target the tumor neovascular biomarker CD13/aminopeptidase N receptor. D-K6L9 is a tumor-selective anti-cancer peptide. To improve the capacity of NGR peptides to target tumors, we joined the NGR and D-K6L9 peptides to form NKL. Read More

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http://dx.doi.org/10.2174/1381612825666190329151326DOI Listing

Evaluation and exploitation of bioactive compounds of walnut, Juglans regia.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh Polizu St 1-7, 011061 Bucharest. Romania.

In the last few years, a great importance has been given to natural materials (such as walnuts, peanuts, chestnuts) due to their medicinal and pharmaceutical uses induced by the presence of natural agents, including polyphenols. Juglans regia is a traditional plant that has been used since ancient times in traditional medicine for the treatment of various diseases like microbial infections, stomach ache, thyroid dysfunctions, cancer, heart diseases and sinusitis. Recently, scientific attention for phytochemical profile of walnut by-products is increasing due to their valuable active constituents. Read More

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http://dx.doi.org/10.2174/1381612825666190329150825DOI Listing
March 2019
4 Reads

Valproic Acid and the Liver Injury in Patients with Epilepsy: An update.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN. United States.

Background: Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity. Long-term VPA therapy is also related to increased risk for the development of non-alcoholic fatty liver disease (NAFLD). In this review, metabolic elimination pathways of VPA in the liver and underlying mechanisms of VPA-induced hepatotoxicity are discussed. Read More

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http://dx.doi.org/10.2174/1381612825666190329145428DOI Listing
March 2019
5 Reads

A review of the most important medicinal plants effective on cardiac ischemia-reperfusion injury.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord. Iran.

Introduction: Ischemia, referring to reduction and restriction of perfusion to myocardial tissue which involves coronary artery through the formation of misplaced clots and thrombosis, is one of the most important cardiovascular diseases. Plant-based compounds help to improve or prevent disease through affecting the factors involved in the disease. This review was conducted to report the medicinal plants and factors effective on cardiac ischemia-reperfusion (I/R) injury to supplement the knowledge about this disease and its prevention and treatment using certain medicinal plants and their active compounds. Read More

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http://dx.doi.org/10.2174/1381612825666190329144016DOI Listing
March 2019
1 Read

Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What We Have Learned On the Genetic Variants of Drug Transporters.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing. China.

Background: Methotrexate (MTX) is one of the leading chemotherapeutic agents with the best demonstrated efficacies against childhood acute lymphoblastic leukemia (ALL). Due to the narrow therapeutic range, significant inter- and intra-patient variabilities of MTX, non-effectiveness and/or toxicity occur abruptly to cause chemotherapeutic interruption or discontinuation. The relationship between clinical outcome and the systemic concentration of MTX has been well established, making the monitor of plasma MTX levels critical in the treatment of ALL. Read More

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http://dx.doi.org/10.2174/1381612825666190329141003DOI Listing
March 2019
2 Reads
3.452 Impact Factor

Safety and Efficacy of Tocolytics for the Treatment of Spontaneous Preterm Labour.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Research Unit of Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense. Denmark.

Background: Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Attempts to reduce the burden may be proactive using biochemical or biophysical prediction and preventative measures. If these efforts fail, then the approach may have to be reactive using tocolytics to inhibit spontaneous preterm labour. Read More

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http://dx.doi.org/10.2174/1381612825666190329124214DOI Listing
March 2019
2 Reads

The significance of heat shock protein 70 kDa in the development of acute focal myocardial and cerebral ischemia.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry. Russian Federation.

In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. This review presents a contemporary view of involvement of heat shock proteins (HSPs) in the process of ischemic injury of the heart and brain and summarizes new clinical studies related to the role of HSP70 in patients with atherosclerosis. The main types of these proteins, their receptors, mechanisms of their functioning and the sources of circulating HSP70 are described. Read More

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http://dx.doi.org/10.2174/1381612825666190329123924DOI Listing
March 2019
2 Reads

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062. China.

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. Read More

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http://dx.doi.org/10.2174/1381612825666190329123436DOI Listing
March 2019
2 Reads

The Low Molecular Weight Brain Derived Neurotrophic Factor Mimetics With Antidepressant-Like Activity.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmacogenetics, V.V. Zakusov Research Institute of Pharmacology, ul. Baltijskaya, 8, 124315 Moscow. Russian Federation.

The search for new highly-effective, fast-acting antidepressant drugs is extremely relevant. Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression. BDNF is a key regulator of neuroplasticity in the hippocampus and the prefrontal cortex, the dysfunction of which is considered to be the main pathophysiological hallmark of this disorder. Read More

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http://dx.doi.org/10.2174/1381612825666190329122852DOI Listing
March 2019
2 Reads

Recent advances in knowledge of natural-derived bioactive as modulating agents of the renin-angiotensin-aldosterone system: therapeutic benefit in cardiovascular diseases.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Laboratório de Eletrofisiologia e Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS. Brazil.

Background: One of the biggest challenges of public health worldwide is reducing the number of events and deaths related to the cardiovascular system. Numerous approaches have been applied to reach this goal, and drug treatment intervention has been indispensable and an effective strategy for reducing both cardiovascular morbidity and mortality. Renin-angiotensin-aldosterone system (RAAS) blockade is currently one of the most important targets for cardiovascular drug therapy. Read More

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http://dx.doi.org/10.2174/1381612825666190329122443DOI Listing
March 2019
2 Reads

Visit-to-visit blood pressure variability and arterial stiffness: Which came first: the chicken or the egg?

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Shobara City Soryo Clinic, Shobara. Japan.

Earlier studies have shown that visit-to-visit blood pressure (BP) variability (VVV) was served as a significant independent risk factor of stroke, specifically, in the high-risk elderly of cardiovascular disease (CVD). Although the mechanism is not clearly understood, arterial remodeling such as carotid artery, coronary artery and large aortic artery would be a strong moderator in the relationship between VVV and CVD incidence. Recent studies have provided the evidence that VVV predicted the progression of arterial stiffness. Read More

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http://dx.doi.org/10.2174/1381612825666190329122024DOI Listing
March 2019
13 Reads

Creation Of Cultures Containing Mutations Linked With Cardiovascular Diseases Using Transfection And Genome Editing.

Curr Pharm Des 2019 Mar 29. Epub 2019 Mar 29.

Laboratory of Medical Genetics, National Medical Research Center of Cardiology, Moscow. Russian Federation.

Objective: In this review article, we analyzed the literature on the creation of cultures containing mutations associated with cardiovascular diseases (CVD) using transfection, transduction and editing of the human genome.

Methods: We described different methods of transfection, transduction and editing of the human genome, used in the literature.

Results: We reviewed the researches in which the creation of сell cultures containing mutations was described. Read More

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http://dx.doi.org/10.2174/1381612825666190329121532DOI Listing
March 2019
2 Reads

Long Noncoding RNAs as Diagnostic and Therapeutic Targets for Ischemic Stroke.

Curr Pharm Des 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001. China.

LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity, which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Read More

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http://dx.doi.org/10.2174/1381612825666190328112844DOI Listing
March 2019
1 Read

Collaboration in Regulatory Science to Facilitate Therapeutic Development for Pregnant Women.

Curr Pharm Des 2019 Mar 27. Epub 2019 Mar 27.

Food and Drug Administration: 10903 New Hampshire Ave, Silver Spring, MD. United States.

Background: Therapeutic tragedies of the past, ethical concerns, legal risks, among other factors have led to a conservative approach to clinical research during pregnancy, resulting in a de facto exclusion of pregnant women from most clinical therapeutics trials. As a result, there is a deficit of knowledge regarding the safety and proper dosing of medications during pregnancy, leaving prescribers with limited information available to support clinical decision-making. Additionally, there is little development of treatments for pregnancy-specific conditions. Read More

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http://dx.doi.org/10.2174/1381612825666190328112202DOI Listing
March 2019
1 Read

Antenatal Corticosteroids for Fetal Lung Maturity - Too Much of a Good Thing?

Curr Pharm Des 2019 Mar 26. Epub 2019 Mar 26.

Tommy's Centre for Maternal and Fetal Health at the MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh. United Kingdom.

Background: Between 5-15% of babies are born prematurely worldwide, with preterm birth defined as delivery before 37 completed weeks of pregnancy (term is at 40 weeks of gestation). Women at risk of preterm birth receive antenatal corticosteroids as part of standard care to accelerate fetal lung maturation and thus improve neonatal outcomes in the event of delivery. As a consequence of this treatment, the entire fetal organ system is exposed to the administered corticosteroids. Read More

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http://dx.doi.org/10.2174/1381612825666190326143814DOI Listing
March 2019
2 Reads

Expression profile of MicroRNA: An Emerging Hallmark of Cancer.

Curr Pharm Des 2019 Mar 25. Epub 2019 Mar 25.

Biomedical Research Center, Qatar University, Doha. Qatar.

MicroRNA (miRNAs), a class of small, endogenous non-coding RNA molecules of about 21-24 nucleotides in length, have unraveled a new modulatory network of RNAs that form an additional level of post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). These miRNAs possess the ability to regulate gene expression by modulating the stability of mRNAs, controlling their translation rates, and consequently regulating protein synthesis. Substantial experimental evidence established the involvement of miRNAs in most biological processes like growth, differentiation, development, and metabolism in mammals including humans. Read More

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http://dx.doi.org/10.2174/1386207322666190325122821DOI Listing
March 2019
1 Read

Women's Beliefs about Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists?

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Clinical Pharmacology and Pharmacotherapy Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven. Belgium.

Background: During pregnancy women might weigh benefits of treatment against potential risks to the unborn child. However, non-adherence to necessary treatment can adversely affect both mother and child. To optimize pregnant women's beliefs and medication adherence, community pharmacists are ideally positioned to play an important role in primary care. Read More

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http://dx.doi.org/10.2174/1381612825666190321110420DOI Listing

Stimuli-responsive Drug Delivery Systems as an Emerging Platform for Treatment of Rheumatoid Arthritis.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058. China.

Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied by chronic inflammation. Due to the long-term infiltration in inflammatory sites, joints were steadily deteriorated, eventually resulting in functional incapacitation and disability. Despite of the considerable effect, RA sufferers treated with current drug therapeutic efficacy were exposed to severe side effects. Read More

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http://dx.doi.org/10.2174/1381612825666190321104424DOI Listing
March 2019
2 Reads

Non-clinical Models to Determine Drug Passage into Human Breast Milk.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Herestraat 49-box 921, 3000 Leuven . Belgium.

Background: Successful practice of clinical perinatal pharmacology requires a thorough understanding of the pronounced physiological changes during lactation and how these changes affect various drug disposition processes. In addition, pharmacokinetic processes unique to lactation have remained understudied. Hence, determination of drug disposition mechanisms in lactating women and their babies remains a domain with important knowledge gaps. Read More

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http://dx.doi.org/10.2174/1381612825666190320165904DOI Listing
March 2019
1 Read

Pharmacokinetics, Placental and Breastmilk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatrics, The George Washington University, School of Medicine & Health Sciences, Washington, DC. United States.

Background: Remarkable progress has been achieved in the identification of HIV infection in pregnant women and prevention of vertical HIV transmission through maternal antiretroviral treatment (ART) and neonatal antiretroviral drug (ARV) prophylaxis in the last two decades. Millions of women globally are receiving combination ART throughout pregnancy and breastfeeding, periods associated with significant biological and physiological changes affecting the pharmacokinetics (PK) and pharmacodynamics (PD) of ARVs. The objective of this review was to summarize currently available knowledge on the PK of ARVs during pregnancy and transport of maternal ARVs through the placenta and into the breastmilk. Read More

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http://dx.doi.org/10.2174/1381612825666190320162507DOI Listing

Next Generation Medical Management of Postpartum Hemorrhage.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

The George Washington University, School of Medicine and Health Sciences, Washington, DC. United States.

Background: Postpartum hemorrhage remains a significant contributor to morbidity and mortality of women of childbearing age worldwide. Trends in both incidence and severity of postpartum hemorrhage are increasing which has resulted in an imperative to identify drugs that could target prevention and/or treatment of these postpartum hemorrhages in women living in high, middle and low-income countries.

Method: We have reviewed current advances in the medical management of postpartum hemorrhage focusing on non-uterotonic therapy. Read More

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http://dx.doi.org/10.2174/1381612825666190320155337DOI Listing
March 2019
2 Reads

Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: from Bench to Bedside.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Cluster Woman and Child, Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven. Belgium.

Background: Persistent pulmonary hypertension (PPH) is one of the main causes of mortality and morbidity in infants affected by congenital diaphragmatic hernia (CDH). Since the structural changes that lead to PPH take place already in utero, a treatment starting in the prenatal phase may prevent the occurrence of this complication.

Objective: To summarize the development process of antenatal sildenafil for CDH. Read More

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http://dx.doi.org/10.2174/1381612825666190320151856DOI Listing
March 2019
3 Reads

Mobile health applications for prenatal assessment and monitoring.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE. United Kingdom.

Background: Mobile health is an exciting, fast-paced domain that is likely to improve prenatal care.

Methods: In this narrative review, we summarise the use of mobile health applications in this setting with special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of their use, highlighting the need for robust regulations and guidelines before their widespread introduction into prenatal care.

Results: Remote monitoring devices for four areas of prenatal care are reported: (1) (cardio)-tocography; (2) blood glucose levels; (3) blood pressure; and (4) prenatal ultrasound. Read More

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http://dx.doi.org/10.2174/1381612825666190320140659DOI Listing
March 2019
1 Read

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.

Curr Pharm Des 2019 03 20. Epub 2019 Mar 20.

Organ Systems, KU Leuven, Department of Development and Regeneration, Leuven. Belgium.

Background: In clinical pharmacokinetic (PK) studies, pregnant women are significantly underrepresented because of ethical and legal reasons which leads to a paucity of information on potential PK changes in this population. As a consequence, pharmacometric tools became instrumental to explore and quantify the impact of PK changes during pregnancy.

Methods: we explore and discuss the typical characteristics of population PK and physiologically based pharmacokinetic (PBPK) models with specific focus on pregnancy and postpartum. Read More

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http://dx.doi.org/10.2174/1381612825666190320135137DOI Listing

Retinal and Choroidal Changes after Anti Vascular Endothelial Growth Factor Therapy for Neovascular Age-related Macular Degeneration.

Curr Pharm Des 2019 Mar 19. Epub 2019 Mar 19.

Department of Ophthalmology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan. Korea.

Objective: To investigate changes in retinal nerve fiber layer, ganglion cell-inner plexiform layer, and choroidal thickness in the macular area in patients with neovascular age-related macular degeneration who received repeated intravitreal ranibizumab and aflibercept treatments.

Methods: This retrospective study included 90 eyes of 90 treatment-naive patients. Fifty eyes were treated with intravitreal injections of aflibercept, and 40 were treated with intravitreal injections of ranibizumab. Read More

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http://dx.doi.org/10.2174/1381612825666190319165824DOI Listing

Methodological Approaches To Evaluate Fetal Drug Exposure.

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

Université Paris Descartes, EA7323, Sorbonne Paris Cité. France.

Background: Drug prescriptions are usual during pregnancy, however women and their fetuses still remain an orphan population with regard to drugs efficacy and safety. Most xenobiotics diffuse through the placenta and some of them can alter fetus development resulting in structural abnormalities, growth or functional deficiencies.

Methods: Summarize the different methodologies developed towards the prediction of fetal drug exposure. Read More

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http://dx.doi.org/10.2174/1381612825666190319102812DOI Listing
March 2019
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Treatments for iron deficiency (ID): Prospective organic iron fortification.

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047. China.

Iron deficiency, one of the most common nutritional deficient disorders, frequently affects infants, adolescents and pregnant women and impairs growth, development and immune responses. Iron deficiency may also be secondary to gastrointestinal conditions such as gastrectomy and inflammatory bowel disease, as well as cancer and chronic uremia. Iron supplementation is the most commonly selected treatment option for iron deficiency. Read More

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http://dx.doi.org/10.2174/1381612825666190319111437DOI Listing
March 2019
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Therapeutic potential of pigment epithelium-derived factor in cancer.

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatric Surgery, Kurume University School of Medicine, Kurume 830-0011. Japan.

Pigment epithelium-derived factor (PEDF) is one of the serine protease inhibitors with multifunctional properties, which is produced by various types of organs and tissues. There is an accumulating body of evidence that PEDF plays an important role in the maintenance of tissue homeostasis. Indeed, PEDF not only works as an endogenous inhibitor of angiogenesis, but also suppresses oxidative stress, inflammatory and thrombotic reactions in cell culture systems, animal models, and humans. Read More

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http://dx.doi.org/10.2174/1381612825666190319112106DOI Listing
March 2019
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Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy. Japan.

Background: Thromboembolic ischemic stroke, which is mainly caused by hypertension, as well as plasma dyslipidemia, arterial fibrillation and diabetes, is a leading cause of death in the US and other countries. Numerous clinical trials for thrombolytic drugs, which aimed to pharmacologically dissolve thrombi, were conducted from the 1950s, when the first thrombolytic therapy was performed.

Method: We will summarize the pathophysiologic features of ischemic stroke, and the history of thrombolytic therapy, and discuss the recent progress that has been made in the ongoing development of thrombolytic drugs. Read More

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http://dx.doi.org/10.2174/1381612825666190319115018DOI Listing
March 2019
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Transcriptional characteristics of activated macrophages.

Curr Pharm Des 2019 Mar 19. Epub 2019 Mar 19.

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow. Russian Federation.

Macrophages are key players in human innate immunity that protect the organism from pathologic agents, including infection and malignant cells. The spectrum of their functions includes initiation and maintaining on inflammation, cleaning of pathogens and cell debris, as well as inflammation resolution and tissue remodeling and repair. Such wide spectrum is reflected by the great variety of macrophage phenotypes based on activation of distinct transcription patterns in response to different stimuli. Read More

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http://dx.doi.org/10.2174/1381612825666190319120132DOI Listing
March 2019
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Neural Networks in Generalized Epilepsy and Novel Antiepileptic Drugs.

Curr Pharm Des 2019 Mar 19. Epub 2019 Mar 19.

Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems, University of Salamanca, Salamanca. Spain.

Background: In previous works, alterations of neurotransmitters and neuropeptides in the brain areas involved in generalized epilepsy have been reported.

Objective: We reviewed the alterations of these neurotransmitters and neuropeptides in the following brain areas involved in generalized epilepsy: hippocampus, hypothalamus, thalamus and cerebral cortex. In these brain areas, the neural networks are also actualized. Read More

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http://dx.doi.org/10.2174/1381612825666190319121505DOI Listing
March 2019
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Circulating Insulin-like Growth Factor-1 Levels in Patients with Rheumatoid Arthritis : A Meta-analysis.

Curr Pharm Des 2019 Mar 19. Epub 2019 Mar 19.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui. China.

Background And Objectives: Insulin-like growth factor-1 (IGF-1) levels have been investigated in rheumatoid arthritis (RA), however, produced inconsistent results. The purpose of this meta-analysis was to derive a more precise conclusion about serum/plasma IGF-1 levels in RA patients.

Methods: PubMed, Embase and the Cochrane Library databases were searched up to December 2018 in English, and the studies comparing serum/plasma IGF-1 levels between RA group and healthy control group were what we are interested in. Read More

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http://www.eurekaselect.com/170831/article
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http://dx.doi.org/10.2174/1381612825666190319124009DOI Listing
March 2019
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Emerging Research Paradigm for Infant Drug Exposure Through Breast Milk.

Authors:
Shinya Ito

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

Division of Clinical Pharmacology & Toxicology Hospital for Sick Children University of Toronto. Canada.

Background: Information on drug secretion into milk is insufficient due to exclusion of lactating women from clinical trials and drug development processes. As a result, non-adherence to necessary drug therapy and discontinuation of breastfeeding occur, even if the predicted level of infant exposure is low. In contrast, inadvertent infant exposure to drugs in breast milk continues to happen due to lack of rational risk assessment, resulting in serious toxicity cases including death. Read More

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http://dx.doi.org/10.2174/1381612825666190318165932DOI Listing
March 2019
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