7,667 results match your criteria Current Pharmaceutical Design[Journal]


Nanocrystals: An Overview of Fabrication, Characterization and Therapeutic Applications in Drug Delivery.

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER, Raebareli), Raebareli (U.P). India.

Approximately 40 % drugs in the market are having poor aqueous solubility related problems and 70 % molecules in discovery pipeline are being practically insoluble in water. Nanocrystals is a prominent tool to solve the issue related to poor aqueous solubility and helps in improving the bioavailability of many drugs as reported in literature. Nanocrystals can be prepared by top down methods, bottom up methods and combination methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190215121148DOI Listing
February 2019

3D Printing In Personalized Drug Delivery.

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

Centre of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi. India.

Background: Personalized medicines are becoming more popular as they enables the use of patient's genomics and hence help in better drug design with fewer side effects. In fact several doses can be combined into one dosage form which suits the patient's demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190215122208DOI Listing
February 2019
3.452 Impact Factor

The Mechanisms of Actions of Aldosterone and its Antagonists in Cardiovascular Disease.

Curr Pharm Des 2019 Feb 14. Epub 2019 Feb 14.

Clinic for Internal Disease Intermedica, University of Nis, Institute Niska Banja, Nis. Serbia.

Background: Aldosterone, through its actions on Mineralcorticosteroid Receptors (MR), controls fluid and electrolyte balance, but also exerts various direct deleterious actions on the vasculature. A number of aldosterone antagonists have been manufactured to reverse these effects.

Objective: A comprehensive review of the underlying mechanisms of the actions of aldosterone and its antagonists in cardiovascular disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190215100502DOI Listing
February 2019

The Relationship between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-Analysis study.

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord. Iran.

Introduction: Prostate cancer is the most common malignant cancer in men worldwide and after lung cancer is the second leading cause of cancer deaths in men. The purpose of this study was to investigate the relationship between prostate cancer and metformin consumption in men.

Method: The current study is a systematic and meta-analysis review based on the PRISMA statement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190215123759DOI Listing
February 2019

Oxidative Stress and Cancer.

Authors:
James E Klaunig

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

School of Public Health Indiana University Bloomington, Indiana . United States.

Background: Cancer is a major cause death in the worldwide. The etiology of cancer is linked environmental and genetic inheritance causes. Approximately 90 percent of all human cancers have an environmental cause (non-genetic inheritance) predominantly through lifestyle choices (smoking, diet, UV radiation) with the remainder infections and chemical exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190215121712DOI Listing
February 2019

Advances in Ultrasound Mediated Transdermal Drug Delivery.

Curr Pharm Des 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614. United States.

Low frequency ultrasound-assisted drug delivery has been widely investigated as a non-invasive method to enhance the transdermal penetration of drugs. Using this technique, a brief application of ultrasound is used to permeabilize skin for a prolonged time. In this review, an overview on ultrasound is detailed to help explain the parameters that could be modulated to obtain the desired ultrasound parameters for enhanced transdermal drug delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190211163948DOI Listing
February 2019

Lung on a Chip for drug screening and design.

Curr Pharm Des 2019 Feb 8. Epub 2019 Feb 8.

Department of Bioengineering, Gebze Technical University, 41400, Kocaeli . Turkey.

Lung-on-a-chip is a micro device that combines the techniques of bioengineering, microbiology, polymer science and microfluidics disciplines in order to mimic physicochemical features and microenvironments, multicellular constructions, cell-cell interfaces of a human lung. Specifically, most novel lung on a chip designs consist of two micro-channeled outer parts, flexible and porous Polydimethylsiloxane (PDMS) membrane to create separation of air-blood chamber and subsidiary vacuum channels which enable stretching of the PDMS membrane to mimic movement mechanisms of the lung. Therefore, studies aim to emulate both tissue and organ functionality since it shall be creating great potential for advancing the studies about drug discovery, disease etiology and organ physiology compared with 2D (two dimensional) and 3D (three dimensional) cell culture models and current organoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190208122204DOI Listing
February 2019
1 Read

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology.

Curr Pharm Des 2019 02 8. Epub 2019 Feb 8.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge. United States.

The role of endovascular interventions has progressed rapidly over the past several decades. While animal models have long served as the mainstay for the advancement of this field, the use of in vitro models has become increasingly widely adopted with recent advances in engineering technologies. Here we review the strategies, mainly including bioprinting and microfabrication, that allow for fabrication of biomimetic vascular models that will potentially serve to supplement the conventional animal models for convenient investigations of endovascular interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612824666180416114325DOI Listing
February 2019

Sensor-free and sensor-based heart-on-a-chip platform: A review of design and applications.

Curr Pharm Des 2019 Feb 7. Epub 2019 Feb 7.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027. China.

Drug efficacy and toxicity are key factors of drug development. Conventional 2D cell models or animal models have their limitations for the efficacy or toxicity assessment in preclinical assays, which induce the failure of candidate drugs or withdrawal of approved drugs. Human organs-on-chips (OOCs) emerged to present human-specific properties based on their 3D bioinspired structures and functions in the recent decade. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190207170004DOI Listing
February 2019

Recent advances in high-throughput platforms with engineered biomaterial microarrays for screening of cell and tissue behavior.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of. Korea.

For the last decades, bioengineers have developed myriad biomaterials for the regenerative medicine. Developments of screening techniques is essential in understanding complex behavior of cells in the biological microenvironments. Conventional approaches to screening of cellular behavior in vitro have limitations in terms of accuracy, reusability, labor-intensive screening, and versatility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190207093438DOI Listing
February 2019

Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, 34668, Haydarpaşa, Istanbul. Turkey.

The skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant end point for the application of pharmaceuticals. The area of in vitro skin tissue engineering has been progressing extensively in the recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206195304DOI Listing
February 2019

Cancer-on-a-chip for drug screening.

Authors:
I-Chi Lee

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan. Taiwan.

The oncology pharmaceutical research spent a shocking amount of money on target validation and drug optimization in preclinical models because many oncology drugs fail during clinical trial III. One of the most important reason of oncology drug failures in clinical trials may due to the poor predictive tool of existing preclinical models. Therefore, in cancer research and personalized medicine field, it is critical to improve the effectiveness of preclinical predictions of the drug response of patients to therapies and to reduce costly failures in clinical trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206235233DOI Listing
February 2019

The role of Steroids and NSAIDs in prevention and treatment of postsurgical cystoid macular edema.

Curr Pharm Des 2019 Feb 5. Epub 2019 Feb 5.

Private Practice, Gdańsk. Poland.

Background: Pseudophakic cystoid macular edema (PCME) remains one of the most common vision threatening complications of phacoemulsification cataract surgery (PCS). Pharmacological therapy is the current mainstay of both prophylaxis, and treatment of patients undergoing PCS. We aimed to review of pharmacological treatment options for PCME, which primarily includes topical steroids, topical nonsteroidal anti-inflammatory drugs (NSAIDS), periocular and intravitreal steroids, as well as anti-vascular endothelial growth factor therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206104524DOI Listing
February 2019

Pharmacotherapy for choroidal neovascularization due to uncommon causes.

Curr Pharm Des 2019 Feb 5. Epub 2019 Feb 5.

Department of Ophthalmology & Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong. Hong Kong.

Background: Choroidal neovascularization (CNV) in adults is most commonly associated with neovascular age-related macular degeneration (AMD) and pathologic myopia. Though less common, CNV can also develop from other conditions such as uveitis, central serous chorioretinopathy, angioid streaks, intraocular tumors, hereditary chorioretinal dystrophies, or can be idiopathic in origin. If left untreated, CNV may cause visual loss because of exudation of intraretinal or subretinal fluid, retinal or subretinal hemorrhage, or fibrosis involving the macula. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206105943DOI Listing
February 2019

Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Department of chemistry, Ben-Gurion University of the Negev, Beer-Sheva, -84105. Israel.

Despite the fact that protein and peptide therapeutics are widely employed in the treatment of various diseases, their delivery is posing an unembellished challenge to the scientists. It was discovered that delivery of these therapeutic systems through oral route is easy with high patient compliance. However, proteolytic degradation and absorption through the mucosal epithelium are the barriers in this route. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206211458DOI Listing
February 2019

Nanotechnology: Revolutionizing the Science of Drug Delivery.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, 58102. United States.

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206222415DOI Listing
February 2019
5 Reads
3.452 Impact Factor

Pharmaceutical product development exploiting 3D printing technology: Conventional to novel drug delivery system.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Research and Development, Jamjoom Pharmaceuticals, Jeddah 21442. Saudi Arabia.

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206195808DOI Listing
February 2019

Design, synthesis, pharmacological evaluation and vascular effects of delphinidin analogues.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

MINT, UNIV Angers, INSERM 1066, CNRS 6021, IRIS-IBS-CHU, 4 rue Larrey, 49100, Angers. France.

Background: Among polyphenolic compounds suggested to prevent cardiovascular diseases (CVDs) and to explain the "French paradox", the anthocyanidin delphinidin (Dp) has been reported to support at least partly the vascular beneficial effects of dietary polyphenolic compounds including those from fruits and related products as red wine. It has also been highlighted that Dp interacts directly with the active site of estrogen receptor α (ERα), leading to an activation of endothelial NO synthase (eNOS) pathway thus contributing to the prevention of endothelial dysfunction in mice aorta. However, anthocyanidins have a very low bioavailability and despite a well described in vitro efficacy, the very high hydrophilicity and the physicochemical instability of Dp might explain the lack of in vivo reported effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206144913DOI Listing
February 2019
1 Read

A Combination of Ulinastatin and Xuebijing Amplifies Neuroprotection after Transient Cerebral Ischemia via Attenuating Apoptosis Signal Pathways in Hippocampus.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology and Neuroscience Center First Hospital of Jilin University. China.

Background: Ulinastatin (UTI) plays the beneficial roles in modifying cerebral ischemic injury evoked by cardiac arrest (CA). XueBiJing (XBJ), comprised of extracts from Chinese herbals, has been used for the treatment of sepsis and ischemic disorders linked to multiple organ dysfunction syndromes. The current study was to find interventions that can enhance effectiveness of these drugs and further to provide a fundamental for their rational application in clinical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206224134DOI Listing
February 2019
1 Read

Recent advances in half-life extension strategies for therapeutic peptides and proteins.

Curr Pharm Des 2019 Feb 5. Epub 2019 Feb 5.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin. China.

Peptides and proteins are two classes of molecules with attractive possibilities for therapeutic applications. However, the bottleneck for the therapeutic application of many peptides and proteins is their short half-lives in vivo, typically just a few minutes to hours. Half-life extension strategies have been extensively studied and many of them have been proved to be effective in generation of long-acting therapeutics with improved pharmacokinetic and pharmacodynamic properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206105232DOI Listing
February 2019

Predictive Value of Methods Measuring Platelet Activation for Ischemic Events in Patients Receiving Clopidogrel: A Meta-analysis.

Curr Pharm Des 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacy, Peking University First Hospital, Beijing. China.

This study investigates the efficiency and predictive value of light-transmission aggregometry (LTA), vasodilator-stimulated phosphoprotein (VASP) and VerifyNow for ischemia in patients undergoing percutaneous coronary intervention (PCI). Studies that used LTA, VASP or VerifyNow to predict ischemia were included, and their quality and efficiency were analyzed using Review Manager 5.3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206114724DOI Listing
February 2019
1 Read

Testosterone Replacement Therapy Has Limited Effect on Increasing Bone Mass Density in Older Men: a Meta-analysis.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Changzhi Medical College, address: No. 161, Jiefangdong Street, Changzhi, Shanxi. China.

Background: Testosterone insufficiency may play a role in age-related decreases in bone mass density (BMD) and osteoporosis in aging men. Testosterone replacement therapy (T therapy) seems to be a simple and convenient way to increase BMD and improve the condition of osteoporosis.

Objective: To evaluate the effects of T therapy in increasing BMD among older men with low serum testosterone concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206223244DOI Listing
February 2019

Influence of Hormones on Sjögren's Syndrome.

Curr Pharm Des 2018 ;24(35):4167-4176

Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021, China.

Sjögren's syndrome (SS) is an immune system oral disorder that is characterized generally by dry mouth and eyes. In this review, SS classification, presentation and pathogenesis are briefly discussed. Moreover, the epidemiology of SS regarding sex, age and association with other complications are also presented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612824666181010153536DOI Listing
January 2018
1 Read

Complementary and Integrative Medicine: Personalized Health Care for Cancer and Chronic Inflammatory Diseases.

Curr Pharm Des 2018 ;24(35):4091-4092

King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138161282435190117102756DOI Listing
January 2018

Precision Medicine on Chronic Disease Incorporating Experimental and Computational Biology.

Authors:
Bing Niu

Curr Pharm Des 2018 ;24(34):3989

School of Life Sciences Shanghai University Shanghai 200444, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138161282434190117093652DOI Listing
January 2018

Role of Advanced Glycation End-products in Carcinogenesis and their Therapeutic Implications.

Curr Pharm Des 2019 Jan 30. Epub 2019 Jan 30.

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal. Germany.

Aging is one of the biggest risk factors for the major prevalent diseases such as cardiovascular diseases, neurodegeneration and cancer, but due to the complex and multifactorial nature of the aging process, the molecular mechanisms underlying age-related diseases are not yet fully understood. Research has been intensive in the last years aiming to characterize the pathophysiology of aging and develop therapies to fight age-related diseases. In this context advanced glycation end products (AGEs) have received attention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130145549DOI Listing
January 2019

Safety of new oral anticoagulants for patients with chronic kidney disease".

Curr Pharm Des 2019 Jan 30. Epub 2019 Jan 30.

Department of Vascular and Endovascular Surgery, Angiology and Phlebology Poznan University of Medical Sciences . Poland.

Background: The objective of this review was to assess whether direct oral anticoagulants (DOACs) are the alternative for vitamin K antagonists (VKA) in patients with mild-to-moderate chronic kidney disease (CKD).

Methods: An analysis of current DOAC trials and studies was performed focusing on subjects with CKD.

Results: This review concludes that although DOACS are not recommended for patients with advanced CKD (CrCl<30mL/min) and patients on dialysis, this group of drugs is a reasonable choice for patients with mild to moderate CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130144051DOI Listing
January 2019

Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges.

Curr Pharm Des 2019 Jan 30. Epub 2019 Jan 30.

Early Clinical Development, Pfizer, Inc., Cambridge, MA. United States.

The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130141310DOI Listing
January 2019

Current and future pharmacologic therapies for diabetic retinopathy.

Curr Pharm Des 2019 Jan 30. Epub 2019 Jan 30.

Bascom Palmer Eye Institute, Miami, FL. United States.

Background: Currently, diabetic retinopathy is the leading cause of permanent visual loss in working-age adults in industrialized nations. The chronic microangiopathic changes associated with diabetic retinopathy lead to the most common causes of severe permanent visual loss: diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR). Multiple studies have evaluated different pharmacotherapies for different levels of retinopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130140717DOI Listing
January 2019
1 Read

Pharmacological adjuncts to vitrectomy surgery.

Curr Pharm Des 2019 Jan 30. Epub 2019 Jan 30.

Florence University, Florence . Italy.

Pharmacological adjuncts to vitrectomy surgery are useful tools to better deal with surgery. Their introduction has enriched the therapeutic choice before, during and after operations. Although several classifications could be made to frame adjuncts to vitrectomy, we preferred to divide the pharmacological adjuncts to vitrectomy surgery for therapeutic use in the pre-operatory procedure (neo-adjuvant), for intraoperative use and for post-operatory practice (adjuvant). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130125136DOI Listing
January 2019

Bioavailability enhancement of poorly soluble drugs: The holy grail in pharma industry.

Curr Pharm Des 2019 Jan 29. Epub 2019 Jan 29.

Pharmaceutics and Pharmacokinetics Division, CSIR-CDRI, Lucknow. India.

Background: Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe the systemic availability of a drug. Bioavailability assessment is imperative in order to demonstrate whether the drug attains the desirable systemic exposure for an effective therapy. Bioavailability has become a subject of importance in drug discovery and development studies in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130110653DOI Listing
January 2019

Why Polycystic Ovary Syndrome (PCOS) needs long-term management?

Curr Pharm Des 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing. China.

Background: Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with numerous severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169465/article
Publisher Site
http://dx.doi.org/10.2174/1381612825666190130104922DOI Listing
January 2019
4 Reads

Current therapy and nutraceuticals for the treatment of patients with dyslipidemias.

Curr Pharm Des 2019 Jan 29. Epub 2019 Jan 29.

U.O.C. Division of Immunohematology, Transfusion Medicine and Transplant Immunology, Clinical Department of Internal Medicine and Specialistics, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, University of Campania "L. Vanvitelli", Naples. Italy.

Coronary heart disease (CHD) remain the leading cause of disability and death in industrialized Countries. Among many conditions that contribute to the etiology and progression of CHD, the presence of high LDL-C levels represent the major risk factor. Therefore, the reduction of LDL-C levels play a key role in the management of patients with high or very high cardiovascular risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190130101108DOI Listing
January 2019

Proteasome Inhibitors In Cancer Therapy And Their Relation To Redox Regulation.

Curr Pharm Des 2019 Feb 1. Epub 2019 Feb 1.

Department of Biochemistry, Faculty of Medicine / Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, 34854 Maltepe, Istanbul. Turkey.

Redox homeostasis is important for the maintenance of cell survival. Under physiological conditions, redox system works in a balance and involves activation of many signaling molecules. Regulation of redox balance via signaling molecules is achieved by different pathways and proteasomal system is a key pathway in this process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190201120013DOI Listing
February 2019

Baicalin Promotes Osteogenic Differentiation of Human Cementoblast Lineage Cells Via the Wnt/β Catenin Signaling Pathway.

Curr Pharm Des 2018 ;24(33):3980-3987

Department of Orthodontics and Craniofacial Development Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: Baicalin constitutes a natural bioactive flavonoid extracted from Scutellaria baicalensis Georgi that mediates bone formation. However, the biological functions of baicalin in cementoblasts remain unclear. The purpose of this study was to examine the effects of baicalin on osteogenic differentiation of human cementoblast (HCEM) cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612824666181116103514DOI Listing
January 2018

Neuropeptides: From Bench to Bedside.

Curr Pharm Des 2018 ;24(33):3867

The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138161282433190109122611DOI Listing
January 2018

Computational Perspective on the Current State of the Methods and New Challenges in Cancer Drug Discovery.

Curr Pharm Des 2018 ;24(32):3725-3726

The State Key Laboratory of Microbial Metabolism, College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, No: 800 Dongchuan Road, Minhang, Shanghai, 200240, China.

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/168805/article
Publisher Site
http://dx.doi.org/10.2174/138161282432190109105339DOI Listing
January 2018
4 Reads

Pharmacotherapy of vitreomacular traction.

Curr Pharm Des 2019 Jan 23. Epub 2019 Jan 23.

Sydney Retina Clinic & Day Surgery, (Lvl 13) 187 Macquarie St, Sydney, NSW. Australia.

Vitreomacular traction occurs due to incomplete or anomalous posterior vitreous detachment. Over time, the vitreous pulls anteriorly and causes retinal distortion and eventually reduced vision. Traditionally, vitreomacular traction was treated with vitrectomy surgery. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169302/article
Publisher Site
http://dx.doi.org/10.2174/1381612825666190124102148DOI Listing
January 2019
5 Reads

Pharmacotherapy of Myopic Choroidal Neovascularization.

Curr Pharm Des 2019 Jan 23. Epub 2019 Jan 23.

Bascom Palmer Eye Institute, Miami, FL. United States.

Background: Myopic choroidal neovascularization (CNV) is a common cause of central visual loss in patients with high myopia, and the most common form of CNV in younger individuals. Pharmacologic therapy is the current mainstay of treatment of these patients.

Methods: Review of pharmacological treatment options for myopic CNV, which primarily involves intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF) agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190124102641DOI Listing
January 2019

Pharmacotherapy of central serous chorioretinopathy: review of the current treatments.

Curr Pharm Des 2019 Jan 23. Epub 2019 Jan 23.

IRCCS - Fondazione Bietti, Rome. Italy.

Background: Central serous chorioretinopathy (CSC) is the fourth most frequent retinal disorder in terms of prevalence. It typically occurs in young subjects and affects men more often than women. CSC is characterized by serous retinal detachment (SRD) involving mainly the macular area. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169299/article
Publisher Site
http://dx.doi.org/10.2174/1381612825666190123165914DOI Listing
January 2019
3 Reads

Novel Long-Acting Pharmacotherapy for Exudative Age Related Macular Degeneration.

Curr Pharm Des 2019 Jan 23. Epub 2019 Jan 23.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv. Israel.

Exudative age-related macular degeneration (AMD) is a major indication for the administration of intravitreal injections of anti-VEGF agents, which have been established as a very effective pharmacotherapy for this disease. However, treatment with anti-VEGF agents requires a very large number of patient visits for monitoring and treatment. Strategies for achieving a longer duration of pharmacological action are currently being developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190123165216DOI Listing
January 2019

Photo- and Sono-dynamic therapy: A review of mechanisms and considerations for pharmacological agents used in therapy incorporating light and sound.

Curr Pharm Des 2019 Jan 22. Epub 2019 Jan 22.

Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093. China.

As irreplaceable energy sources of minimally invasive treatment, light and sound have, separately, laid solid foundations in their clinic applications. Limited by relatively shallow penetration depth of light, traditional therapeutic modality of photodynamic therapy (PDT) usually involves superficial targets such as shallow seated skin conditions, head and neck cancers, eye disorders, early stage cancer of esophagus, etc. For ultrasound-driven sonodynamic therapy (SDT), however, accessibility to various organs is permitted by superior transmission and focusing ability of ultrasound in biological tissues, enabling multiple therapeutic applications including treating glioma, breast cancer, hematologic tumor and opening blood-brain-barrier (BBB), etc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190123114107DOI Listing
January 2019
1 Read

The role of antioxidants in cancer, friends or foes?

Authors:
B Poljsak I Milisav

Curr Pharm Des 2019 Jan 22. Epub 2019 Jan 22.

Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana. Slovenia.

Consumption of dietary supplements by millions of people is increasing [1]. Between 64 to 81% of cancer patients and survivors use multivitamin supplements after the cancer diagnosis [2]. The use of antioxidants during cancer therapy has been a hot topic in medical science for the last 20 years without clear answers and recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190123112647DOI Listing
January 2019

Emerging Therapeutic Targets in Oncologic Photodynamic Therapy.

Curr Pharm Des 2019 Jan 22. Epub 2019 Jan 22.

"Victor Babes" National Institute of Pathology, Bucharest. Romania.

Background: Reactive oxygen species sustain tumorigenesis and cancer progression through deregulated redox signalling which also sensitize cancer cells to therapy. Photodynamic therapy (PDT) is a promising anti-cancer therapy based on a provoked singlet oxygen burst, exhibiting a better toxicological profile than chemo-and radiotherapy. Important gaps in the knowledge on underlining molecular mechanisms impede on its translation towards clinical applications. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169257/article
Publisher Site
http://dx.doi.org/10.2174/1381612825666190122163832DOI Listing
January 2019
2 Reads

Recent Advances on Cytotoxic Sesquiterpene Lactones.

Curr Pharm Des 2019 Jan 18. Epub 2019 Jan 18.

Department of Biochemistry and Molecular Biology, Research Institute in Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria. Spain.

Sesquiterpene lactones are naturally occurring compounds that have attracted considerable attention because to their vast array of biological activities. These plant-derived compounds contain the α-methylene-γ-butyrolactone functional group, which is the structural requirement for their pharmacological activities. Many of them exhibit cancer cell cytotoxicity and are promising anticancer agents through multiple mechanisms of action. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190119114323DOI Listing
January 2019
1 Read

Genetics of Nonalcoholic Fatty Liver Disease: a 2018 Update.

Curr Pharm Des 2019 Jan 18. Epub 2019 Jan 18.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. Italy.

Nonalcoholic fatty liver disease (NAFLD), now the leading cause of liver damage worldwide, is epidemiologically associated with obesity, insulin resistance and type 2 diabetes, and is a potentially progressive condition to advanced liver fibrosis and hepatocellular carcinoma. However, there is a huge interindividual variability in liver disease susceptibility. Inherited factors play also an important role in determining disease predisposition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190119113836DOI Listing
January 2019
2 Reads

Noncoding RNAs emerging as novel biomarkers in pancreatic cancer.

Curr Pharm Des 2019 Jan 19. Epub 2019 Jan 19.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam. Netherlands.

Noncoding RNAs play important regulatory roles in diverse biological processes and their misregulation might lead to different diseases, including cancer. Previous studies have reported the evolving role of miRNAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190119125804DOI Listing
January 2019
1 Read

Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy.

Curr Pharm Des 2019 Jan 19. Epub 2019 Jan 19.

Cardiovascular Research Institute, National University Health System. Singapore.

Background: Human mesenchymal stem cell-derived exosomes (hMSC-Exo) have been shown to reduce ischemia/reperfusion injury (I/R) in multiple models. I/R-induced apoptosis or autophagy play important roles in cell death. However, little or no reports demonstrate any roles of hMSC-Exo in this regards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190119130441DOI Listing
January 2019
1 Read

Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids.

Curr Pharm Des 2019 Jan 17. Epub 2019 Jan 17.

Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT. United States.

Background: Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA makes them the reagent of choice for gene therapy-based applications.

Objective: To review important gene therapy based applications of regular and chemically modified peptide nucleic acids in combination with nanotechnology Method: Selective research of the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190117164901DOI Listing
January 2019
5 Reads

Topical Drug Delivery of anti-infectives employing Lipid-Based Nanocarriers: Dermatokinetics as an important tool.

Curr Pharm Des 2019 Jan 18. Epub 2019 Jan 18.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh. India.

Background: The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The major challenge in the management of topical infections lies in antibiotic resistance which leads to severe complications and hospitalizations resulting in economic burden and high mortality rates.

Methods: Topical delivery employing lipid-based carriers has been a promising strategy to overcome the challenges of poor skin permeation and retention along with large doses which need to be administered systemically. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/169145/article
Publisher Site
http://dx.doi.org/10.2174/1381612825666190118155843DOI Listing
January 2019
2 Reads