1,880 results match your criteria Current Pharmaceutical Biotechnology [Journal]


Corticosteroid Catabolism by Klebsiella pneumoniae as a Possible Mechanism for Increased Pneumonia Risk.

Curr Pharm Biotechnol 2019 Mar 13. Epub 2019 Mar 13.

Department of Biochemistry, University of Calcutta, Kolkata, West Bengal, 700019. India.

Background: Several strains of Klebsiella pneumoniae are responsible for causing pneumonia in lung and thereby causing death in immune-suppressed patients. In recent year, few investigations have reported the enhancement of K. pneumoniae population in patients using corticosteroid containing inhaler. Read More

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http://dx.doi.org/10.2174/1389201020666190313153841DOI Listing

Effect of pre-analytical conditions on prothrombin time and partial activated thromboplastin time.

Curr Pharm Biotechnol 2019 Mar 14. Epub 2019 Mar 14.

INSA, National Institute of Health Dr. Ricardo Jorge, Department of Health Promotion and Chronic Diseases, Rua Alexandre Herculano, 321, 4000-055 Porto. Portugal.

Background: Clinical analysis often involves clotting assays. Although the guidelines suggest the storing and freezing of samples before these assays, there are contradictory results in the literature. The objective of this study was to analyse the effect of the temperature and the storage of plasma sample on Prothrombin Time (PT) and Activated Partial Thromboplastin Time (aPTT) in clinical samples for 65 healthy patients. Read More

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http://dx.doi.org/10.2174/1389201020666190314125918DOI Listing

Microorganisms Isolated from Stored Meat in India, with Potential Antimicrobial Activity against Food Pathogens.

Curr Pharm Biotechnol 2019 Mar 14. Epub 2019 Mar 14.

Department of Biotechnology, Rajalakshmi Engineering College, Chennai. India.

Background: World Health Organization has estimated that 1 in 10 people fall ill and 4, 20, 000 die every year from eating contaminated food. Food pathogen like Escherichia, Salmonella, Staphylococcus and Listeria poses a serious threat to human health.

Objective: The objective was to isolate microbes from meat stored at refrigerated conditions and evaluate the antimicrobial activity of the cell-free supernatant against food pathogens. Read More

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http://dx.doi.org/10.2174/1389201020666190314125534DOI Listing

Medicinal plant compounds for combating the multi-drug resistant pathogenic bacteria: A review.

Curr Pharm Biotechnol 2019 Mar 8. Epub 2019 Mar 8.

Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida-201306, U.P. . India.

Background: Globally, people utilize plants as a main source of remedy to heal various ailments. Medicinal plants have been utilized to treat ailments since the invention of modern scientific systems of medicine. The common remedy of infectious diseases, mainly depends on the inhibition capacity of compounds or killing potential. Read More

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http://dx.doi.org/10.2174/1872210513666190308133429DOI Listing
March 2019
1 Read

Evaluation of polyphenolic profile and antibacterial activity of pomegranate juice in combination with rifampin (R) against MDR-TB clinical isolates.

Curr Pharm Biotechnol 2019 03 8. Epub 2019 Mar 8.

Department of Medical Microbiology, Faculty of Medicine, Çukurova University, Adana. Turkey.

Background: The global rise of multi-drug resistant M. tuberculosis demands unconventional treatment to enhance the efficiency of current drugs. Punica granatum, which is known as pomegranate, is considered as a member of the Punicaceae family. Read More

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http://dx.doi.org/10.2174/1389201020666190308130343DOI Listing
March 2019
1 Read

Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-Alcoholic Fatty Liver Disease.

Curr Pharm Biotechnol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pathology, Gangneung Asan Hospital, University of ulsan College of medicine, Gangneung. Korea.

Red ginseng is a traditional medicine that has been used to treat numerous metabolic and inflammatory diseases. Probiotic administration has been established to have beneficial effects in non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to determine whether a combination of Korean red ginseng (KRG) and probiotics could synergistically reduce NAFLD and liver inflammation compared with the effects reported for each individual product. Read More

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http://dx.doi.org/10.2174/1389201020666190311143554DOI Listing

The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus.

Curr Pharm Biotechnol 2019 Mar 7. Epub 2019 Mar 7.

Departamento de Microbiologia, Universidade Estadual de Londrina, CEP 86051-990, Londrina, Paraná. Brazil.

Background: Herpes simplex virus (HSV) and poliovirus (PV) are both agents of major concern in the public health system. It has been shown that Dimorphandra gardneriana galactomannans can be used as solubilizer vehicles in medicine manufacture. Mangiferin is the major constituent of Mangifera indica and presents multiple medicinal and biological activities. Read More

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http://dx.doi.org/10.2174/1389201020666190307130431DOI Listing
March 2019
1 Read

Role of Probiotics in Prophylaxis of Helicobacter Pylori Infection.

Curr Pharm Biotechnol 2019 Feb 27. Epub 2019 Feb 27.

Department of Biotechnology, Jaypee Institute of Information Technology, Sector - 62, Noida, U.P., . India.

Helicobacter pylori, a pathogenic bacterium, has been known to be the root cause of numerous gastrointestinal disorders. In patients showing symptoms of its infection, antibiotic therapy is a likely treatment. However, the high cost of antibiotic therapy, associated antibiotic resistance along with other adverse effects has led to the use of probiotics for Helicobacter pylori treatment. Read More

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http://dx.doi.org/10.2174/1389201020666190227203107DOI Listing
February 2019

Osteoarthritis: Prognosis and Emerging Therapeutic Approach for Disease Management.

Curr Pharm Biotechnol 2019 Feb 27. Epub 2019 Feb 27.

Assam University Biotech-Hub, Assam University, Silchar, Assam-788011. India.

Background: Osteoarthritis, a disorder of joints is incredibly prevalent in older age. The contemporary cure handy against the osteoarthritis is to confer superficial relief, which consists of the comfort from pain and swelling temporarily.

Methods: we will discuss various type of factor responsible for onset of OA and its severity. Read More

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http://dx.doi.org/10.2174/1389201020666190227225349DOI Listing
February 2019

Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules.

Curr Pharm Biotechnol 2019 Feb 22. Epub 2019 Feb 22.

Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V. M. Gorbatov's Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow. Russian Federation.

Background: The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals.

Methods: In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency and studied the features of the gender impact of the complex extract of immunocompetent organs (thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular weight less than 30 kDa administered to male and female rats. Results and Conslusion: The gender differences in impact of tissue-specific biomolecules (30 kDa fraction) on hematological parameters (leukocytes, erythrocytes, platelets), functional activity of immune system (IL-2, IL-4, IL-6, complement system, IgG, IgM), biochemical parameters of hepatocytes functioning (activity of ALP and LDG), carbohydrate metabolism (glucose), lipid metabolism (triglycerides). Read More

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http://dx.doi.org/10.2174/1389201020666190222184814DOI Listing
February 2019
2 Reads

Comparative evaluation of conventional and novel extracts of stem bark of Terminalia arjuna for antihypertensive activity in BSO induced oxidative stress based rat model.

Curr Pharm Biotechnol 2019 Feb 22. Epub 2019 Feb 22.

Faculty of Pharmacy, Jamia Hamdard, New Delhi. India.

Background: Terminalia arjuna (TA) has been reported and explored traditionally for its cardiotonic properties while the mechanism of antihypertensive effect of TA has not been clearly reported.

Methods: The oxidative stress is a major cause for hypertension, hence different extracts of TA having variable marker yield were evaluated for its antihypertensive effect in buthionine sulfoxamine (BSO) induced oxidative stress based model. Soxhlet extraction (SE), room temperature extraction (RTE), microwave assisted extraction (MAE), ultrasound assisted extraction (USAE) were quantitatively estimated for marker compounds arjunolic acid and arjunic acid through HPTLC. Read More

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http://dx.doi.org/10.2174/1389201020666190222185209DOI Listing
February 2019

Sodium Oleate Increases Ampicillin Sensitivity in Methylophilus quaylei Biofilms on Teflon and Polypropylene

Curr Pharm Biotechnol 2019 02 22. Epub 2019 Feb 22.

Department of biotechnology and industrial pharmacy, M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow. Russian Federation.

Background: Drug combination is a new therapy to improve antibiotic deficiency treatment towards biofilm resistance.

Objective: This study was conducted to determine the potential effect of sodium oleate to inhibit established biofilms of two strains, methylotrophic bacteria Methylophilus quaylei in combination with ampicillin. Minimum inhibitory concentration (MIC) of ampicillin was determined and added in combination with sodium oleate and examined on planktonic and established biofilms of two strains M. Read More

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http://dx.doi.org/10.2174/1389201020666190222191656DOI Listing
February 2019
1 Read

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic- related Liver Diseases and Hepatocellular Carcinoma.

Curr Pharm Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

Superior School of Medicine, Nacional Polytechnic Institute. Mexico.

Background: Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause non-alcoholic fatty liver disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. Read More

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http://www.eurekaselect.com/170090/article
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http://dx.doi.org/10.2174/1389201020666190219122357DOI Listing
February 2019
7 Reads

Expression of NRP-1 and NRP-2 in Endometrial Cancer.

Curr Pharm Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

Department of Histology and Embryology, Medical University of Silesia. Poland.

Background: Neuropilins (NRPs) participate in many processes related to the cancer development such as angiogenesis, lymphangiogenesis and metastasis. Although endometrial cancer is one of the most common gynecological cancers, it has not been studied in terms of NRPs expression.

Objective: The aim of this study was to investigate the potential utility of NRPs as important factors in the diagnosis and treatment of endometrial cancer. Read More

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http://dx.doi.org/10.2174/1389201020666190219121602DOI Listing
February 2019
2 Reads

Erratum to Cytotoxic Effects and Production of Cytokines Induced by the Endophytic Paenibacillus polymyxa RNC-D In Vitro.

Authors:

Curr Pharm Biotechnol 2018 ;19(14):1177

CORRIGENDUM Corrigendum to Manuscript entitled Cytotoxic Effects and Production of Cytokines Induced by the Endophytic Paenibacillus polymyxa RNC-D In Vitro by Débora M. Neris1,3,*, Genoveva L.F. Read More

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http://dx.doi.org/10.2174/138920101914190111105915DOI Listing
January 2018
1 Read

A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Acute Asthma in Guinea Pigs.

Curr Pharm Biotechnol 2019 Feb 14. Epub 2019 Feb 14.

PHARMENTERPRISES LLC, Moscow. Russian Federation.

Background: Corticosteroids are the best drug to treat asthma, however, 10% of cases are resistant to corticosteroids. Thus, new therapeutic approaches for asthma treatment are required.

Objective: To test the efficacy of a novel glutarimide derivative XC8 in a sephadex-induced lung inflammation in rats and in acute ovalbumin induced allergic asthma in guinea pigs. Read More

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http://dx.doi.org/10.2174/1389201020666190215103505DOI Listing
February 2019
1 Read

Separation, Characterization and Discriminant Analysis of Subvisible Particles in Biologics Formulations.

Curr Pharm Biotechnol 2019 Feb 13. Epub 2019 Feb 13.

BMS Research & Development, GRS&B, Princeton, New Jersey 08543. United States.

The presence of subvisible particles (SVPs) in parenteral formulations of biologics is a major challenge in the development of therapeutic protein formulations. Distinction between proteinaceous and non-proteinaceous SVPs is vital in monitoring formulation stability. The current compendial method based on light obscuration (LO) has limitations in the analysis of translucent/low refractive index particles. Read More

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http://dx.doi.org/10.2174/1389201020666190214100840DOI Listing
February 2019

Current Advances in Food Science & Health Promotion (Part I).

Curr Pharm Biotechnol 2018 ;19(13):1017-1018

Department of Food Science and Nutrition, School of Environment, University of the Aegean, Lemnos, Greece.

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http://dx.doi.org/10.2174/138920101913190108104855DOI Listing
January 2018

Higher Anti-angiogenesis Activity, Better Cellular Uptake and Longer Half-life of a Novel Glyco-modified Endostatin by Polysulfated Heparin.

Curr Pharm Biotechnol 2018 ;19(12):996-1004

National Glycoengineering Research Center, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.

Background: Endostatin (ES) is a promising anti-angiogenesis protein and has been approved for the treatment of non-small cell lung cancer, but short half-life, poor stability and nonspecific delivery caused great pain to patients and produced unsatisfactory treatment effectiveness.

Objective: In this work, in order to overcome these disadvantages, ES was covalently modified by polysulfated heparin (PSH) with the expectancy of longer half-life, higher anti-angiogenesis activity and better cellular uptake.

Methods: To characterize the cellular uptake, flow cytometry and confocal laser scanning microscopy were used to study the intracellular localization of fluorescein isothiocyanate-labeled ES and PSH-ES in EAhy926 endothelial cells. Read More

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http://dx.doi.org/10.2174/1389201020666181120164753DOI Listing
January 2018
2 Reads

Improve Healthcare quality through Mortality Committee: Retrospective analysis of Bambino Gesù Children Hospital's ten years' experience 2008-2017.

Curr Pharm Biotechnol 2019 Feb 11. Epub 2019 Feb 11.

Medical Direction, Bambino Gesù Children's Hospital, Piazza di Sant'Onofrio 4, 00165, Rome. Italy.

Introduction: Healthcare quality improvements are one of the most important goals to reach a better and safer healthcare system. Reviewing in-hospital mortality data is useful to identify areas for improvement, and to monitor the impact of actions taken to avoid preventable cases, such as those related to healthcare associated infections (HAI).

Methods: In this paper, we present the experience of the Mortality Committee of Bambino Gesù Children Hospital (OPBG). Read More

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http://dx.doi.org/10.2174/1389201020666190211124436DOI Listing
February 2019

Antitumoral and anticholinesterasic activity of the seven species from Rubiaceae.

Curr Pharm Biotechnol 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Health Sciences, Federal University of Grande Dourados, Dourados-MS. Brazil.

Background: The genus Psychotria and Palicourea are reported as a source of alkaloids and iridoids, which exhibit biological activities. This study aimed to evaluate the antiproliferative, anticholinesterase and LC/MS potential of the methanolic extract of seven species among the genus found in Mato Grosso do Sul region in Brazil.

Methods: The extracts were submitted to antiproliferative activity against ten human tumor cell lines. Read More

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http://dx.doi.org/10.2174/1389201020666190211154550DOI Listing
February 2019
2 Reads

Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest.

Curr Pharm Biotechnol 2019 Feb 11. Epub 2019 Feb 11.

Department of Food Science & Human Nutrition, Agricultural University of Athens, Athens. Greece.

Crude glycerol (Glol), used as substrate for screening eleven natural Yarrowia lipolytica strains in shake-flask experiments. Aim of this study was to assess the ability of the screened strains to produce biomass (dry cell weight; X), lipid (L), citric acid (Cit), mannitol (Man), arabitol (Ara) and erythritol (Ery), compounds presenting pharmaceutical and biotechnological interest, in glycerol-based nitrogen-limited media, in which initial glycerol concentration had been adjusted to 40 g/L. Citric acid may find use in biomedical engineering (i. Read More

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http://dx.doi.org/10.2174/1389201020666190211145215DOI Listing
February 2019
1 Read

Nutritional culturomics and big data: Macroscopic patterns of change in food, nutrition and diet choices.

Curr Pharm Biotechnol 2019 Feb 11. Epub 2019 Feb 11.

Department of Food Science and Nutrition; School of the Environment, University of the Aegean. Greece.

Nutritional culturomics (NCs) is a specific focus area of culturomics epistemology developing digital humanities and computational linguistics approaches to search for macro-patterns of public interest in food, nutrition and diet choice as a major component of cultural evolution. Cultural evolution is considered as driver at the interface of environmental and food science, economy and policy. The paper presents an epistemic programme that builds on the use of big data from web-based services such as Google Trends, Google Adwords or Google Ngram Viewer. Read More

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http://dx.doi.org/10.2174/1389201020666190211125550DOI Listing
February 2019

Evaluation of Activity Kinetic Parameters of SK319cys, As a New Cysteine Variant of Streptokinase: A Comparative Study.

Curr Pharm Biotechnol 2019 Feb 8. Epub 2019 Feb 8.

R&D department, Research and production complex, Pasteur Institute of Iran, Karaj. Iran.

Background: Despite the extensive use of streptokinase in thrombolytic therapy, its administration may have some shortcomings like allergic reactions and relatively low half life. Specific PEGylation on cysteine at desired sites of streptokinase may alleviate these deficiencies and improve the quality of treatment.

Objective: This study was carried out to create a new cystein variant of streptokinase and compare its activity with formerly mutated SK263cys, SK45cys and intact streptokinase (Ski) to introduce superior candidates for specific PEGylation. Read More

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http://dx.doi.org/10.2174/1389201020666190208155808DOI Listing
February 2019
1 Read

Theoretical investigation of design space for multi layer drug eluting bioresorbable suture threads.

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Institute of Mechanical Engineering and Material Engineering, Department of Innovative Technologies, SUPSI, 6928 Manno. Switzerland.

The here presented work is focused on the development of a comprehensive model for the description of drug release from a double - layer bioresorbable suture thread and the therapeutic efficacy of the active compounds delivered in the surrounding tissue. In particular, the system under investigation is composed by a core of slow-degrading poly-lactic-acid-co-ε-caprolactone (PLCL), where an antibiotic compound (Vancomycin) is loaded, surrounded by a shell of a fast-degrading polylactic-co-glycolic acid (PLGA) which contains an anesthetic drug (Lidocaine hydrochloride) for the post-surgical pain relief. This system is of potential interest for the combined effects provided by the different active molecules, but the different release and polymer degradation dynamics, as well as their mutual influence, do not allow an intuitive a priori evualuation of device behavior, which can be rationalized through mathematical modeling. Read More

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http://dx.doi.org/10.2174/1389201020666190206200411DOI Listing
February 2019

Regulation of Vaginal Microbiome by Nitric Oxide.

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO, 64108. United States.

In this review, the composition and regulation of vaginal microbiome that displays an apparent microbial diversity and interacts with other microbiota in the body were presented. The role of nitric oxide (NO) in the regulation of vaginal microflora in which lactobacillus species typically dominate has been delineated from the perspective of maintaining gynecologic ecosystem and prevention of onset of bacteriostatic vaginosis (BV) and/or sexually transmitted diseases (STD) including HIV-1 transmission. The interactions between NO and vaginal microbiome and its influence on the levels of Lactobacillus, hormones and other components were described. Read More

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http://dx.doi.org/10.2174/1389201020666190207092850DOI Listing
February 2019
1 Read

In vivo evaluation and Alzheimer's disease treatment outcome of siRNA loaded dual targeting drug delivery system.

Curr Pharm Biotechnol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127. China.

To deliver drugs to treat Alzheimer's disease (AD), nanoparticles should firstly penetrate through blood brain barrier, and then target neurons. Recently, we developed an Apo A-I and NL4 dual modified nanoparticle (ANNP) to deliver beta-amyloid converting enzyme 1 (BACE1) siRNA. Although promising in vitro results were obtained, the in vivo performance was not clear. Read More

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http://dx.doi.org/10.2174/1389201020666190204141046DOI Listing
February 2019
3 Reads

Functional Biomolecule Delivery Systems and Bioengineering in Cartilage Regeneration.

Curr Pharm Biotechnol 2019 02 6. Epub 2019 Feb 6.

Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, Catania. Italy.

Osteoarthritis (OA) is a common degenerative disease which involves articular cartilage, and leads to total joint disability in the advanced stages. Due to its avascular and aneural nature, damaged cartilage cannot regenerate itself. Stem cell therapy and tissue engineering represent a promising route in OA therapy, in which cooperation of mesenchymal stem cells (MSCs) and three-dimensional (3D) scaffolds contribute to cartilage regeneration. Read More

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http://dx.doi.org/10.2174/1389201020666190206202048DOI Listing
February 2019
1 Read
2.511 Impact Factor

Establishment of novel cells stably secreting various human IL-18 recombinant proteins.

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Center for Therapeutic Innovation, Gene Research Center for Frontiers Life Sciences, Nagasaki University, Graduate School of Biomedical Sciences, 1-12-14 Sakamoto, Nagasaki 852-8523. Japan.

The immunotherapies against cancer, autoinmmune diseases or infection are remarkable development. These days programmed cell death (PD)-1 antibody-induced immune checkpoint blockade or chimeric antigen recpetor-T cells (CAR-T) have been shown to have eminent therapeutic effects on tumor development. We have focused on adoptive transfer with human gamma delta T cells for novel immunotherapies. Read More

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http://dx.doi.org/10.2174/1389201020666190206203640DOI Listing
February 2019
14 Reads

Effect of powdered activated carbon as advanced step in wastewater treatments on antibiotic resistant microorganisms.

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Laboratory of applied microbiology, Department of Environment, Construction and Design, University of Applied Sciences and Arts of Southern Switzerland, Via Mirasole 22a, 6501 Bellinzona. Switzerland.

Conventional wastewater treatment plants discharge important amounts of antibiotic resistant bacteria and antibiotic resistance genes into natural water bodies contributing to the spread of antibiotic resistance. Some advanced wastewater treatment technologies have been shown to effectively decrease the number of bacteria. Nevertheless, there is still a lack of knowledge about the effectiveness of these treatments on antibiotic resistant bacteria and antibiotic resistant genes. Read More

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http://dx.doi.org/10.2174/1389201020666190207095556DOI Listing
February 2019
1 Read

Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA).

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz. Iran.

Background And Objective: Antisense oligonucleotides are able to modulate splicing patterns and offer therapeutic intervention for cancer and other diseases. Considering TdT potential as a target in cancer therapy, the present study aimed to investigate splicing alteration of TdT pre-mRNA in Molt-4 cells using peptide nucleic acid (PNA) octaarginine and cholic acid conjugates.

Methods: We examined 16 mer PNAs targeting 5' and 3' junctions of intron 7 and addressed their mRNA splicing modulation effects using RT-PCR analysis. Read More

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http://dx.doi.org/10.2174/1389201020666190206202650DOI Listing
February 2019

Chemical composition, antioxidant and anti-inflammatory activity evaluation of the Lebanese propolis extract.

Curr Pharm Biotechnol 2019 Feb 6. Epub 2019 Feb 6.

Environmental Health Research Lab (EHRL), Faculty of Sciences V, Lebanese University, Nabatieh. Lebanon.

Background: Propolis is a resinous substance produced by bees and known to possess antioxidant, antimicrobial, antiproliferative and anti-inflammatory activities.

Objective: this study is aimed at evaluating the in vivo and in vitro anti-inflammatory potential of the crude ethanolic extract (CE) of Lebanese propolis and its ethyl acetate fraction (EAF).

Method: Chemical content of propolis was characterized using high-performance liquid chromatography and LC-MS/MS. Read More

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http://dx.doi.org/10.2174/1389201020666190206201241DOI Listing
February 2019
2 Reads

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways.

Curr Pharm Biotechnol 2019 Jan 19. Epub 2019 Jan 19.

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah. Saudi Arabia.

Numerous studies have been performed in understanding the development of cancer. Though, the mechanism of action of genes in the development of cancer remains to be explained. The current mode of treatment of cancer shows adverse effect on normal cells and also alter the cell signalling pathways. Read More

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http://www.eurekaselect.com/169171/article
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http://dx.doi.org/10.2174/1389201020666190119142331DOI Listing
January 2019
7 Reads

The Capability to Forecast Response to Therapy with Regard to The Time and Intensity of The Inflammatory Process in vitro in Dermal Fibroblasts Induced by IL-12.

Curr Pharm Biotechnol 2018 ;19(15):1232-1240

Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, ul. Francuska 20/24, 40-027 Katowice, Poland.

Background: The aim of the study was to evaluate the changes in the expression of genes - TNF-α, IFN-γ, depending on the time and concentration of IL-12 used to expose the Normal Human Dermal Fibroblast (NHDF) cells.

Methods: The material for the study included NHDF exposed to IL-12 in various IL-12 concentrations (1/10/100 ng/ml) and exposure time 0.5h, 1h, 2h, 4h, 8h, 24h, compared to the control. Read More

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http://dx.doi.org/10.2174/1389201020666190111163312DOI Listing
January 2018
1 Read

Pattern Recognition Receptors and Control of Innate Immunity: Role of Nucleic Acids.

Authors:
Silvia Fischer

Curr Pharm Biotechnol 2018 ;19(15):1203-1209

Institute of Biochemistry, Medical School, Justus-Liebig-University, Giessen 35392, Germany.

The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protein-1-like receptors, mannose-receptor, or retinoic acid-inducible gene-1- like receptors that initiate proper host defense mechanisms. In addition to pathogen-associated molecular patterns, a series of endogenous danger-associated molecular patterns, such as nucleic acids, are recognized by pattern recognition receptors, which serve as body´s own alarm signals under sterile conditions, such as ischemic injuries, trauma, tumors, tissue transplants, or autoimmune diseases. Thus, exogenous as well as endogenous nucleic acids can function as "alarmins" to alert the body about danger or disease by triggering inflammation, dendritic cell maturation, and stimulate the immune response resulting in the release of cytokines, which in turn can augment the local inflammatory environment. Read More

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http://www.eurekaselect.com/168881/article
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http://dx.doi.org/10.2174/138920112804583087DOI Listing
January 2018
7 Reads

Neutrophil Extracellular Traps as a Drug Target to Counteract Chronic and Acute Inflammation.

Authors:
Mona Saffarzadeh

Curr Pharm Biotechnol 2018 ;19(15):1196-1202

Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Neutrophil extracellular traps (NET), extruded decondensated chromatin entangled with neutrophil proteases, have been first identified in neutrophils stimulated with bacteria or phorbol myristate acetate (PMA) via activation of NADPH oxidase and the generation of reactive oxygen species. Although the first findings demonstrated the beneficial role of NET formation by trapping the bacteria and limiting their dissemination, numerous studies in the recent decade revealed the multifunctional aspects of NET formation which manifests itself not only in the context of anti-microbial effect but also as a pathological trigger. Uncontrolled and exaggerated NET formation or inability to digest and remove NET have been reported in thrombosis, auto-immune diseases, cancer or even in infertility. Read More

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http://dx.doi.org/10.2174/1389201020666190111164145DOI Listing
January 2018
4 Reads

Molecular Identification and Antimicrobial Activity of Vaginal Lactobacillus sp.

Curr Pharm Biotechnol 2018 ;19(15):1241-1247

Cebeci Hospital Central Laboratory, Faculty of Medicine, Ankara University, Ankara, Turkey.

Background: The genus Lactobacillus has recently been the focal point of researchers due to their ability to produce secondary metabolites with antimicrobial effects.

Objective: The aim of this study was to identify vaginal Lactobacillus sp. by analyzing 16S rRNA gene sequence, to investigate into antimicrobial activities of secondary metabolites produced by these isolates and to determine the quantities of lactic acid, acetic acid and hydrogen peroxide in secondary metabolites using High-Performance Liquid Chromatography. Read More

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http://dx.doi.org/10.2174/1389201020666190110164123DOI Listing
January 2018
1 Read

Comparison of Anti-HCV Activity of Multiple Punica granatum Extracts and Fractions in Virus-infected Human Hepatocytes.

Curr Pharm Biotechnol 2018 ;19(15):1221-1231

Dean Post Graduate Study, Allama Iqbal Medical College, Lahore, Pakistan.

Background: Plants extracts and their bioactive constituents can provide an alternative approach for new treatment. Pakistani flora reveals a huge, largely untapped source of potential antiviral constituents.

Objective: High-cost concerns of direct-acting anti-HCV drugs limit their employment specifically in developing countries like Pakistan. Read More

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http://dx.doi.org/10.2174/1389201020666190104141900DOI Listing
January 2018
2 Reads

The Role of Extracellular Nucleic Acids in Rheumatoid Arthritis.

Curr Pharm Biotechnol 2018 ;19(15):1182-1188

Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Benekestr, 2-8, 61231 Bad Nauheim, Germany.

Chronic inflammation, synovial hyperplasia, and local hypoxia lead to synovial cell activation causing severe joint damage in chronic-inflammatory rheumatoid arthritis (RA). The proinflammatory and joint-destructive property of the increased release of extracellular nucleic acids has been demonstrated for extracellular mitochondrial DNA and oxidized DNA using an arthritis model. Microparticles derived from different cells are able to transport nucleic acids to distant cells and promote cellular activation in RA. Read More

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http://dx.doi.org/10.2174/1389201020666190102150216DOI Listing
January 2018
7 Reads

Hyperglycemia and Diabetes Induced by Glucocorticoids in Nondiabetic and Diabetic Patients: Revision of Literature and Personal Considerations.

Curr Pharm Biotechnol 2018 ;19(15):1210-1220

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

Background: Glucocorticoids are powerful and effective anti-inflammatory and immunosuppressive drugs. They have extensive use in the treatment of different diseases, even though their side effects, such as hypertension, osteoporosis and, in particular, diabetes, are well known. They can exacerbate hyperglycemia in patients with diabetes mellitus or facilitate the development of metabolic disease in apparently healthy subjects, the so-called steroid-induced diabetes mellitus. Read More

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http://dx.doi.org/10.2174/1389201020666190102145305DOI Listing
January 2018
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Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, Ischemia/Reperfusion Injury and Organ Transplantation.

Curr Pharm Biotechnol 2018 ;19(15):1189-1195

Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Munich, Germany.

Extracellular RNA (eRNA), composed of mainly rRNA e.g. released upon cell injury, has previously been shown to have three main detrimental functions in the context of cardiovascular disease: (1) to promote tissue edema by activating the VEGF signal transduction cascade, disrupting endothelial tight junctions and increasing intercellular permeability; (2) to induce thrombus formation by activating the contact phase system of intrinsic blood coagulation; and (3) to increase inflammation by stimulating leukocyte adhesion and transmigration and the mobilization of pro-inflammatory cytokines. Read More

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http://www.eurekaselect.com/168718/article
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http://dx.doi.org/10.2174/1389201020666190102150610DOI Listing
January 2018
4 Reads

Preeclampsia - Aetiopathogenesis and Clinical Management.

Curr Pharm Biotechnol 2018 ;19(10):762-763

Chair and Department of Obstetrics and Perinatology, II Faculty of Medicine with English Language Division Medical University of Lublin Lublin, Poland.

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http://dx.doi.org/10.2174/138920101910181112114656DOI Listing
January 2018
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Novel Therapeutic Approaches and Targets for the Treatment of Cardiovascular and Immunological Diseases.

Curr Pharm Biotechnol 2018 ;19(9):684-685

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.2174/138920101909181024112720DOI Listing
February 2019
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Status of Selinum spp. L. a Himalayan Medicinal Plant in India: A Review of Its Pharmacology, Phytochemistry and Traditional Uses.

Curr Pharm Biotechnol 2018 ;19(14):1122-1134

Department of Botany, University of Lucknow, Uttar Pradesh 226007, India.

There is a growing trend of herbal medicines in India as well as other parts of the world. The use of herbal medicines alone or alongside prescription drugs for disease management is quite common now. We hereby carry out a review of dominant species of Selinum mainly S. Read More

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http://dx.doi.org/10.2174/1389201020666181227150829DOI Listing
January 2018
1 Read

A Recombinant Fab Antibody Against Kwakhurin as a Tool for Sensitive Indirect Competitive ELISA.

Curr Pharm Biotechnol 2018 ;19(14):1170-1176

Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Background: Pueraria candollei var. mirifica (P. candollei), known as White Kwao Krua in Thai, has long been used in traditional Thai medicine for the symptoms of menopause due to the potent estrogenic activity exhibited by the isoflavonoids and chromenes it contains. Read More

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http://www.eurekaselect.com/168573/article
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http://dx.doi.org/10.2174/1389201020666181226105223DOI Listing
January 2018
6 Reads
2.511 Impact Factor

Clinical Trials of Novel Targeted Therapies in Ovarian Cancer: Moving Beyond Poly ADP Ribose Polymerase (PARP) Inhibitors.

Curr Pharm Biotechnol 2018 ;19(14):1114-1121

RD Center, Pacificbio Inc. Irvine, CA 92602, United States.

Background: Epithelial ovarian cancer (EOC) is one of the most common cancers in the female reproductive system and deadliest gynecological cancer in the United States. Standard treatments by surgery and platinum-based chemotherapy are not satisfied for the patients with high risk of relapse. Advances in molecular biology for EOC development have brought several targeted therapies to benefit recurrent patients. Read More

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http://dx.doi.org/10.2174/1389201020666181226123054DOI Listing
January 2018
1 Read
2.511 Impact Factor

Colorectal Cancer: Causes and Evidence of Chemopreventive Treatments.

Curr Pharm Biotechnol 2018 ;19(14):1135-1155

Department of Engineering in Biomedical Systems, Faculty of Engineering, National Autonomous University of Mexico, Exterior Circuit, University City, 04510, Mexico City, Mexico.

Background: Colorectal cancer (CRC) is the second and third most frequent cancer in women and men, respectively; indeed, CRC is placed as the fourth world's most deadly cancer (after lung, liver, and stomach cancer). The incidence of CRC is strongly influenced by nutrition and the high fat/high carbohydrate Western-style diet. CRC is one of the most intensively studied cancer types, partly because of its high prevalence, but also because of the existence of its precursor lesions, tubular or villous adenomas, and more recently serrated adenomas. Read More

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http://www.eurekaselect.com/168575/article
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http://dx.doi.org/10.2174/1389201020666181226112712DOI Listing
January 2018
4 Reads

Phenolic Acids Derivatives - Biotechnological Methods of Synthesis and Bioactivity.

Curr Pharm Biotechnol 2018 ;19(14):1098-1113

Department of Chemistry, Faculty of Food Sciences, Warsaw University of Life Sciences, Warsaw, Poland.

Phenolic acids are secondary plant metabolites belonging to polyphenol classes, widely spread throughout the plant kingdom. The name "phenolic acids", in general, describes phenols that possess one carboxylic acid functionality and they could be divided into three major subclasses: hydroxybenzoic, hydroxycinnamic and hydroxyphenylacetic acids. The great interest in phenolic acids is associated with their high potential for food preservation (antioxidant and antimicrobial activity) and, last but not least, high therapeutic potential. Read More

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http://dx.doi.org/10.2174/1389201020666181217142051DOI Listing
January 2018
3 Reads

Suppressive Effects of the Standardized Extract of Phyllanthus amarus on Type II Collagen-induced Rheumatoid Arthritis in Sprague Dawley Rats.

Curr Pharm Biotechnol 2018 ;19(14):1156-1169

Faculty of Medicine,University of Tabuk, Tabuk 71491, Saudi Arabia.

Background: Standardized extract of Phyllanthus amarus has been shown to possess inhibitory effects on cellular and humoral immune responses in Wistar-Kyoto rats and Balb/c mice.

Objective: In the present study, the standardized extract of P. amarus was investigated for its suppressive effects on type II collagen-induced rheumatoid arthritis (TCIA) in Sprague Dawley rats. Read More

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http://dx.doi.org/10.2174/1389201020666181211124954DOI Listing
January 2018
3 Reads

Optimization of Silver Nanoparticle Synthesis by Banana Peel Extract Using Statistical Experimental Design, and testing of their Antibacterial and Antioxidant Properties.

Curr Pharm Biotechnol 2018 Dec 9. Epub 2018 Dec 9.

Department of Food Science and Nutrition, School of the Environment, University of the Aegean, Mitropoliti Ioakim 2, Myrina Lemnos, 81400. Greece.

In this study, silver nanoparticles (AgNPs) were synthesized using Banana Peel Extract (BPE), and characterized using UV- Vis absorbance spectroscopy, X-Ray Powder Diffraction (XRD), Atomic Force Microscopy (AFM), and Fourier Transform Infrared Spectroscopy (FTIR). UV - Vis absorbance spectroscopy showed the characteristic plasmon resonance of AgNPs at 433 nm. Nanoparticle size (between 5 and 9 nm) was measured using AFM, whereas their crystallinity was shown by XRD. Read More

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http://dx.doi.org/10.2174/1389201020666181210113654DOI Listing
December 2018
3 Reads