216 results match your criteria Current Pediatric Reviews[Journal]


Tinea Imbricata: An Overview.

Curr Pediatr Rev 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics and Department of Dermatology and Skin Sciences, The University of British Columbia, Vancouver, British Columbia. Canada.

Background: Tinea imbricata is a chronic superficial mycosis caused exclusively by Trichophyton concentricum. The condition mainly affects individuals living in primitive and isolated environment in developing countries and is rarely seen in developed countries. Physicians in nonendemic areas might not be aware of this fungal infection. Read More

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http://dx.doi.org/10.2174/1573396315666190207151941DOI Listing
February 2019

Role of Breathing Exercises And Yoga/Pranayam In Childhood Asthma: A Systematic Review.

Curr Pediatr Rev 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi. India.

Background: Various complementary or alternative medicines (including breathing exercises and yoga/pranayama) have been tried as an attractive option to pharmacotherapy in childhood asthma.

Objective: To evaluate the role of breathing exercise and yoga/pranayama as add on therapy to the "pharmacologically recommended treatment" of childhood asthma.

Methods: We searched the published literature through the major databases: Medline via Ovid, PubMed, CENTRAL, Embase, and Google Scholar till June 2018. Read More

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http://dx.doi.org/10.2174/1573396315666190121122452DOI Listing
January 2019
3 Reads

Antimicrobial Stewardship in the Neonatal Intensive Care Unit: an update.

Curr Pediatr Rev 2019 Jan 17. Epub 2019 Jan 17.

Department of Paediatrics, Patras Medical School. Greece.

Neonates represent a vulnerable population for infections and neonatal sepsis is a major cause of mortality and morbidity worldwide. Therefore, antimicrobials are the most commonly prescribed drugs in the Neonatal Intensive Care Unit Setting but unfortunately are quite often used inappropriately with various short and long-term effects. The rational use of antimicrobials is of paramount importance in this population and structured antimicrobial stewardship interventions should be in place. Read More

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http://dx.doi.org/10.2174/1573396315666190118101953DOI Listing
January 2019
2 Reads

"The Compromised Fetal and Neonatal Lives and their Possible Long-term Consequences".

Authors:
Oreste Battisti

Curr Pediatr Rev 2018 ;14(4):211

Emeritus Academic Professor Oreste Battisti, University of Liege (Belgium) And Catholic University of Bukavu, Congo.

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http://dx.doi.org/10.2174/157339631404181221092046DOI Listing
January 2019
1 Read

The role of probiotics in the prevention of necrotizing enterocolitis.

Curr Pediatr Rev 2018 Dec 24. Epub 2018 Dec 24.

Children's Hospital Zagreb, Zagreb. Croatia.

Necrotizing enterocolitis (NEC) is a frequent and severe life-threatening disease affecting the gastrointestinal tract of preterm infants. Given that NEC occurs in a well-defined population of patients, there might be a considerable benefit in identifying specific pharmacological and nutritional preventive strategies, that could reduce the incidence of NEC. Amongst nutritional strategies emphasis has been put on the use of probiotics. Read More

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http://dx.doi.org/10.2174/1573396315666181224123223DOI Listing
December 2018
1 Read

Non-transplant surgical management of short bowel syndrome in children: an overview.

Curr Pediatr Rev 2018 Nov 29. Epub 2018 Nov 29.

University of Florence, Meyer Children's Hospital, Florence. Italy.

Management of severe Short Bowel Syndrome (SBS) is still one of the largest challenges of the medicine. Vast majority of the short bowel patients are children, the conditions that lead to this possible outcome most often are necrotizing enterocolitis (NEC), small intestinal volvulus as a result of intestinal malrotation, gastroschisis and the "apple peel" syndrome. Therefore paediatricians and paediatric surgeons face this challenge most often. Read More

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http://dx.doi.org/10.2174/1573396315666181129164112DOI Listing
November 2018
8 Reads

Long Term Outcome Of Infants With Nec.

Curr Pediatr Rev 2018 Nov 30. Epub 2018 Nov 30.

Pediatric surgery Unit - INFERMI Hospital- Rimini. Italy.

Necrotizing enterocolitis (NEC) is a significant complication for premature newborns. Infants who survive NEC are at increased risk of having poor long-term physiological and neurodevelopmental growth. The objective of this paper is to give a comprehensive description of the long-term consequences of NEC. Read More

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http://dx.doi.org/10.2174/1573396315666181130144925DOI Listing
November 2018
9 Reads

Human Breast Milk-Acquired Cytomegalovirus Infection: Certainties, Doubts And Perspectives.

Curr Pediatr Rev 2018 11 25. Epub 2018 Nov 25.

Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, AOU and University of Cagliari. Italy.

Breast Milk (BM) is the best source of nutrition for newborns, especially if premature. In fact, its beneficial impact on short- and long-term neonatal outcome was deeply described. Unfortunately, BM could not be always so safe, especially due to the possible presence of maternal viruses that can be shed and transferred to the breastfed neonate. Read More

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http://www.eurekaselect.com/167722/article
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http://dx.doi.org/10.2174/1573396315666181126105812DOI Listing
November 2018
12 Reads

Bone manifestation of faulty perinatal hormonal imprinting: a review.

Authors:
G Csaba

Curr Pediatr Rev 2018 Nov 25. Epub 2018 Nov 25.

Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest. Hungary.

Hormonal imprinting takes place at the first encounter between the developing receptor and its target hormone and the encounter determines the receptor's binding capacity for life. In the critical period of development, when the window for imprinting is open, the receptor can be misdirected by related hormones, synthetic hormones, and industrial or communal endocrine disruptors which cause faulty hormonal imprinting with life-long consequences. Considering these facts, the hormonal imprinting is a functional teratogen provoking alterations in the perinatal (early postnatal) period. Read More

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http://dx.doi.org/10.2174/1573396315666181126110110DOI Listing
November 2018
1 Read

Childhood solitary cutaneous mastocytoma: clinical manifestations, diagnosis, evaluation, and management.

Curr Pediatr Rev 2018 Nov 20. Epub 2018 Nov 20.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based on lesion morphology, the presence of a positive Darier sign, and absence of systemic involvement. Knowledge of this condition is important so that an accurate diagnosis can be made.

Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of a solitary cutaneous mastocytoma. Read More

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http://dx.doi.org/10.2174/1573396315666181120163952DOI Listing
November 2018
10 Reads

What is New in Food Allergy?

Curr Pediatr Rev 2018 ;14(3):138

Associate Professor of Pediatric Allergy Food Immunotherapy Program Director Immunology, Allergy and Rheumatology Texas Children's Hospital Baylor College of Medicine Houston, Texas, United States.

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http://dx.doi.org/10.2174/157339631403181107154212DOI Listing
December 2018
7 Reads

The Unlicensed and Off-label Prescription of Medications in General Paediatric Ward: an Observational Study.

Curr Pediatr Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Paediatrics, Hospital De Clínicas De Porto Alegre. Brazil.

Background: The unlicensed (UL) and off-label (OL) prescription of medications is common in paediatrics and does not constitute negligent practice, since there is often no approved alternative.

Aim: to determine the current frequency of UL and OL prescriptions in children from one month to 12 years of age in a paediatric inpatient unit (PIU).

Methods: Observational, prospective study, reviewing the prescriptions of all patients admitted to the PIU in a university hospital in a single week in August 2014 and a single week in January 2015. Read More

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http://dx.doi.org/10.2174/1573396314666181113101506DOI Listing
November 2018
14 Reads

Breath-Holding Spells in Pediatrics: A Narrative Review of the Current Evidence.

Curr Pediatr Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Breath-holding spells are common, frightening, but fortunately benign events. Familiarity with this condition is important so that an accurate diagnosis can be made.

Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of children with breath-holding spells. Read More

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http://dx.doi.org/10.2174/1573396314666181113094047DOI Listing
November 2018
2 Reads

Alpha1-Antitrypsin Deficiency: Transition of Care for the Child With AAT Deficiency into Adulthood.

Curr Pediatr Rev 2018 Nov 12. Epub 2018 Nov 12.

Division of Pediatric Gastroenterology, Hepatology and Nutrition MUSC Children's Hospital, South Carolina. United States.

IMPORTANCE Alpha1-antitrypsin (AAT) deficiency is a common, but underdiagnosed genetic condition, affecting 1 in 1500 individuals, which can present insidiously with liver disease in children. Although clinical practice guidelines exist for the management of AAT deficiency, especially with regards to pulmonary involvement, there are no published recommendations that specifically relate to the management of the liver disease and monitoring for lung disease associated with this condition, particularly in children. OBJECTIVE To review the literature on the management of AAT deficiency-associated liver disease in adults and children. Read More

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http://dx.doi.org/10.2174/1573396314666181113094517DOI Listing
November 2018
12 Reads

Tall stature: a challenge for clinicians.

Curr Pediatr Rev 2018 Nov 4. Epub 2018 Nov 4.

Department of Internal Medicine and Therapeutics, Pediatrics and Adolescent Care Unit, University of Pavia, Strada Nuova 65, 27100 Pavia. Italy.

Clinician generally use the term "tall stature" to define a height more than two standard deviations above the mean for age and sex. In most cases, these subjects present with familial tall stature or a constitutional advance of growth which is diagnosed by excluding the other conditions associated with overgrowth. Nevertheless, it is critical to be able to identify situations in which tall stature or an accelerated growth rate indicate an underlying disorder. Read More

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http://dx.doi.org/10.2174/1573396314666181105092917DOI Listing
November 2018
1 Read

Pathophysiology of Necrotizing Enterocolitis: An Update.

Curr Pediatr Rev 2018 Nov 2. Epub 2018 Nov 2.

University of Florida Department of Pediatrics Division of Neonatology Address: 1600 SW Archer Road Gainesville, Florida. United States.

NEC is a devastating disease that, once present, is very difficult to treat. In the absence of an etiologic treatment, preventive measures are required. Advances in decoding the pathophysiology of NEC are being made but a more comprehensive understanding is needed for the targeting of preventative strategies. Read More

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http://dx.doi.org/10.2174/1573396314666181102123030DOI Listing
November 2018
11 Reads

Management of NEC: surgical treatment and role of traditional X-ray versus Ultrasound imaging, experience of a single centre.

Curr Pediatr Rev 2018 Nov 2. Epub 2018 Nov 2.

Department of Surgery, Santobono-Pausilipon Children Hospital, Napoli. Italy.

Necrotizing enterocolitis is the most common cause of the postnatal critical conditions and remains one of the dominant cause of newborns' death in Neonatal Intensive Care. The morbidity and mortality associated with necrotizing enterocolitis remains largely unchanged and the incidence of necrotizing enterocolitis continues to increase. There is no general agreement regarding the surgical treatment of the necrotizing enterocolitis. Read More

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http://dx.doi.org/10.2174/1573396314666181102122626DOI Listing
November 2018
2 Reads

A Cross-sectional Study of Two Chemotherapy Protocols on Long Term Neurocognitive Functions in Egyptian Children Surviving Acute Lymphoblastic Leukemia.

Curr Pediatr Rev 2018 ;14(4):253-260

Pediatric Oncology Unit, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Introduction: Subtle neurocognitive deficits have been recently observed in Acute Lymphoblastic Leukemia (ALL) survivors.

Aim: We aim to assess the neurocognitive functions of ALL survivors who had been treated with chemotherapy only using two different protocols, and to identify treatment-related risk factors.

Patients And Methods: We carried a multicenter study involving 3 pediatric oncology centers on 100 children who were treated for ALL. Read More

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http://www.eurekaselect.com/166816/article
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http://dx.doi.org/10.2174/1573396314666181031134919DOI Listing
January 2019
15 Reads

Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.

Curr Pediatr Rev 2018 ;14(4):261-268

Kilyos Assessoria, Consultoria, Cursos e Palestras, Sao Paulo, 01311-100, Brazil.

Background: Iron Deficiency Anemia (IDA) is a major public health problem worldwide. Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used for the treatment of IDA and exhibit good tolerability with a low incidence of adverse effects. However, these compounds have important differences in their structures and bioavailability. Read More

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http://www.eurekaselect.com/165885/article
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http://dx.doi.org/10.2174/1573396314666181002170040DOI Listing
January 2019
5 Reads

The Therapeutic Potential of Stem Cells for Bronchopulmonary Dysplasia: "It's About Time" or "Not so Fast" ?

Curr Pediatr Rev 2018 ;14(4):227-238

Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, ON, Canada.

Objective: While the survival of extremely premature infants has improved over the past decades, the rate of complications - especially for bronchopulmonary dysplasia (BPD) - remains unacceptably high. Over the past 50 years, no safe therapy has had a substantial impact on the incidence and severity of BPD.

Methods: This may stem from the multifactorial disease pathogenesis and the increasing lung immaturity. Read More

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http://dx.doi.org/10.2174/1573396314666180911100503DOI Listing
January 2019
9 Reads

Hydrops Fetalis and THE Parvovirus B-19.

Curr Pediatr Rev 2018 ;14(4):239-252

Department of Obstetrics and Gynecology, Democritus University of Medicine in Thrace, Konotin, Greece.

Definition: Hydrops Fetalis (HF) or fetal hydrops is identified as an abnormal interstitial collection of fluid in at least 2 or more compartments of the fetal torso (peritoneal cavity, pleura, and pericardium). An alternative definition discusses about liquor accumulation in two fetal anatomical areas or an effusion in one site and anasarca.

Background: Parvovirus B-19 is a common childhood illness; the virus can cause fetal anemia, non-immune fetal hydrops, and spontaneous abortion and might lead to fetal demise. Read More

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http://dx.doi.org/10.2174/1573396314666180820154340DOI Listing
January 2019
16 Reads

Preterm Birth: Long Term Cardiovascular and Renal Consequences.

Curr Pediatr Rev 2018 ;14(4):219-226

Medecine Neonatale, Hopital La Conception, APHM, Aix-Marseille Universite, Marseille, France.

Background: Cardiovascular and chronic kidney diseases are a part of noncommunicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is such an adverse factor. Read More

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http://www.eurekaselect.com/164626/article
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http://dx.doi.org/10.2174/1573396314666180813121652DOI Listing
January 2019
8 Reads

The Acutely Traumatized Child: Advances and Opportunities.

Authors:
Rodrick Lim

Curr Pediatr Rev 2018 ;14(1)

Associate Professor of Pediatrics Department of Pediatric and Medicine Site Chief Children`s Hospital Emergency Department at LHSC Schulich School of Medicine & Dentistry London, Ontario, Canada.

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http://dx.doi.org/10.2174/157339631401180718111811DOI Listing
January 2018
1 Read

Preface.

Curr Pediatr Rev 2018 ;14(1)

Department of Molecular and Developmental Medicine University of Siena Siena, Italy.

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http://dx.doi.org/10.2174/157339631401180718111554DOI Listing
January 2018
2 Reads

Neonatal and Long-Term Consequences of Fetal Growth Restriction.

Curr Pediatr Rev 2018 ;14(4):212-218

University Paris Diderot, Sorbone Paris-Cite, Inserm U1141, Neonatal intensive care unit, Assistance Publique- Hopitaux de Paris, Robert Debre Children's hospital, Paris, France.

Background: Fetal Growth Restriction (FGR) is one of the most common noxious antenatal conditions in humans, inducing a substantial proportion of preterm delivery and leading to a significant increase in perinatal mortality, neurological handicaps and chronic diseases in adulthood. This review summarizes the current knowledge about the postnatal consequences of FGR, with a particular emphasis on the long-term consequences on respiratory, cardiovascular and neurological structures and functions.

Result And Conclusion: FGR represents a global health challenge, and efforts are urgently needed to improve our understanding of the critical factors leading to FGR and subsequent insults to the developing organs. Read More

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http://dx.doi.org/10.2174/1573396314666180712114531DOI Listing
January 2019
8 Reads

Atopic Dermatitis and Food Allergy: A Paediatric Approach.

Curr Pediatr Rev 2018 ;14(3):171-179

Guy's and St. Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, United Kingdom.

Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, delayed or non-IgEmediated eczematous flares, or a combination of the two. A detailed history is very important when approaching such patients. Read More

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http://dx.doi.org/10.2174/1573396314666180613083616DOI Listing
December 2018
18 Reads

Special Traumatized Populations: Burns Injuries.

Curr Pediatr Rev 2018 ;14(1):64-69

Department of Pediatrics, Schulich School of Medicine, Western University, London, Ontario, Canada.

Background: It is important for physicians treating children to be aware of unique presentations that require expertise and knowledge. One area of importance when caring for traumatized children is Thermal Burn Injuries. Burns commonly result in morbidity in children; as such, the appropriate identification of the severity of the burn and appropriate management are integral to minimize the complications of burns during the acute phase. Read More

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http://dx.doi.org/10.2174/1573396314666180608095033DOI Listing
September 2018
18 Reads

A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome.

Curr Pediatr Rev 2018 ;14(3):196-203

Department of Pediatrics, Hospital Ostallgau-Kaufbeuren, Kaufbeuren, Germany.

Background And Objective: Melkersson Rosenthal syndrome (MRS) is a rare disorder of unknown etiology and comprises the triad: orofacial edema, recurrent facial paralysis and lingua plicata. In the current literature confusing heterogeneity exists, mixing together the historically grown terms cheilitis granulomatosa or granulomatous cheilitis, Melkersson Rosenthal syndrome and the umbrella term Orofacial Granulomatosis (OFG).

Methods: We provide a systematic review comprising all three disease entities of orofacial granulomatosis using the computerized database "Pubmed Medline" entering the keywords "orofacial granulomatosis" (141 references), "Melkersson-Rosenthal syndrome" (207 references), "granulomatous cheilitis" or "cheilitis granulomatosa" (102 references) back to 1956. Read More

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http://dx.doi.org/10.2174/1573396314666180515113941DOI Listing
December 2018
2 Reads

Old and New Treatments for Pediatric Autoimmune Hepatitis.

Curr Pediatr Rev 2018 ;14(3):187-195

Pediatric Hepatology and Liver Transplantation, ISMETT UPMC Palermo, Palermo, Italy.

Background: Autoimmune hepatitis is a rare inflammatory disease of the liver that most frequently affects children and young adults. It is a multifactorial disease of unknown etiology, characteristically progressive in nature, and if left untreated, may lead to cirrhosis and terminal liver failure. It has been known for several decades now that immunosuppressive treatment convincingly alters the outcome of most patients with autoimmune hepatitis and as such it should be started as soon as diagnosis is made. Read More

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http://dx.doi.org/10.2174/1573396314666180516130314DOI Listing
December 2018
3 Reads

Recent changes in the management of patients with food allergy in a tertiary referral centre: A Dietitian's perspective.

Curr Pediatr Rev 2018 May 14. Epub 2018 May 14.

Guys and St Thomas' NHS Foundation Trust. United Kingdom.

It is has been suggested that the prevalence of food allergy has increased over the last few decades with estimates now suggesting between 3.9-8% of children are food allergic (Kattan, 2016). Studies also suggest that rates of food allergy resolution are slowing, meaning more children are remaining allergic for longer (Sicherer et al, 2014). Read More

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http://dx.doi.org/10.2174/1573396314666180514141131DOI Listing
May 2018
2 Reads

Advances in the Management of Food Allergy in Children.

Curr Pediatr Rev 2018 ;14(3):150-155

Childrens Allergy Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Food allergy is common in children. An accurate diagnosis remains a key element in order to instigate an effective management plan. Traditional management strategies have relied on a reactive approach, with allergen avoidance, management of accidental ingestion and monitoring for resolution. Read More

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http://dx.doi.org/10.2174/1573396314666180508164224DOI Listing
December 2018
2 Reads

Febrile Neutropenia in Children with Cancer: Approach to Diagnosis and Treatment.

Curr Pediatr Rev 2018 ;14(3):204-209

Cerrahpasa Faculty of Medicine, Pediatric Hematology-Oncology, Istanbul University, Istanbul, Turkey.

Background: Febrile neutropenia is one of the major acute side effects of intensive treatment in pediatric cancer, necessitating prompt initiation of empirical broad-spectrum antibiotics. Patients may be classified as low or high risk according some risk factors (duration of neutropenia, depth of neutropenia, type of cancer, state of disease, bone marrow involvement, type of treatment, additional health problems). Initial evaluation of the febrile neutropenic child should include the history of the child, a detailed physical examination, blood culture (peripheral and catheter), urinalysis and culture, cultures of lesions. Read More

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http://dx.doi.org/10.2174/1573396314666180508121625DOI Listing
December 2018
1 Read

Anaphylaxis in Children: Epidemiology, Risk Factors and Management.

Curr Pediatr Rev 2018 ;14(3):180-186

Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Feigin Center, 1102 Bates Avenue, Suite 330, MS: BCM320, Houston, Texas, 77030, United States.

Background: Anaphylaxis is defined as a serious, generalized or systemic allergic reaction that is rapid in onset and may cause death. It is unpredictable and can be the result of various allergic triggers including food, insect venom and medication. The European Anaphylaxis Registry confirmed food as the major elicitor of anaphylaxis in children, specifically hen's egg, cow's milk and nuts. Read More

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http://dx.doi.org/10.2174/1573396314666180507115115DOI Listing
December 2018
4 Reads

Demystifying Dysbiosis: Can the Gut Microbiome Promote Oral Tolerance Over IgE-mediated Food Allergy?

Curr Pediatr Rev 2018 ;14(3):156-163

Department of Medicine, Section of Paediatrics, Imperial College London, St. Mary's Hospital Campus, Norfolk Place, United Kingdom.

The growing burden of food allergy is being driven by environmental exposures and the potential role of gut micro-organisms (or 'microbiota') is hotly debated. Early culture-based studies outlined that imbalances between commensal gut constituents ('dysbiosis') early in life may raise the risk of developing allergic disease. A number of studies using animal models describe mechanisms by which specific bacterial taxa within the gut microbiota, their diversity and dietary substrates such as fibre may promote oral tolerance. Read More

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http://dx.doi.org/10.2174/1573396314666180507120424DOI Listing
December 2018
2 Reads

Mini Review - Asthma and Food Allergy.

Curr Pediatr Rev 2018 ;14(3):164-170

Division of Asthma, Allergy and Lung Biology, Department of Paediatric Allergy, King's College London and Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, United Kingdom.

Background: It is well known that there is a common interplay between atopic conditions and that having one atopic condition can predispose to the development of others. The link between asthma and food allergy has been well researched over the years; although the exact interplay between the two atopic conditions is yet to be fully described. Research suggests that children who have both asthma and food allergy are at greater risk of more severe asthmatic episodes. Read More

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http://dx.doi.org/10.2174/1573396314666180507121136DOI Listing
December 2018
3 Reads

Advances in Food Allergy Diagnosis.

Curr Pediatr Rev 2018 ;14(3):139-149

Children's Allergy Service, Evelina Children's Hospital, Guy's and St Thomas' Hospital, London, United Kingdom.

An accurate diagnosis of food allergy is extremely important to guide safe and yet not overly restrictive dietary management. The cornerstone of the diagnosis of food allergy is the clinical history; it allows appropriate selection of the allergens to be tested and interpretation of the results of allergy tests, namely Skin Prick Test (SPT), Specific IgE (sIgE) to allergen extracts and, more recently, specific IgE to allergen components and the Basophil Activation Test (BAT). SPT and sIgE to allergen extracts are very sensitive methods to detect IgE sensitization to a specific food and assess the possibility of spontaneous resolution. Read More

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http://dx.doi.org/10.2174/1573396314666180423105842DOI Listing
December 2018
2 Reads

Special Traumatized Populations: Accidental Hypothermia in Children.

Curr Pediatr Rev 2018 ;14(1):28-33

Department of Pediatrics, Schulich School of Medicine, Western University, London, Ontario, ON, Canada.

Physicians caring for children in trauma settings must consider and treat hypothermia as a cause for morbidity and mortality. Knowledge of treatment of accidental hypothermia with and without an asphyxial event is paramount. Clinicians need to identify hypothermia immediately and be aware of the overall management utilizing aggressive rewarming and cardiopulmonary resuscitation to help improve the survival of these critically ill children. Read More

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http://dx.doi.org/10.2174/1573396314666180412090930DOI Listing
September 2018
4 Reads

Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Novel Therapy for Multidrug Resistant Gram Negative Infections in Children.

Curr Pediatr Rev 2018 ;14(2):97-109

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT 06102, United States.

The rise in Multidrug-resistant (MDR) infections has become a significant problem in both the developing countries and in the United States (U.S.). Read More

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http://www.eurekaselect.com/160327/article
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http://dx.doi.org/10.2174/1573396314666180308150908DOI Listing
September 2018
9 Reads

The Prevalence of Dyslipidemia and Other Cardiovascular Risk Factors in Youth with Diabetes.

Curr Pediatr Rev 2017 ;13(4):277-280

Pediatric Endocrinology and Diabetes, Cook Children's Medical Center, Fort Worth, Texas, United States.

Background: Individuals diagnosed with diabetes mellitus have an increased risk of cardiovascular disease, often leading to premature morbidity and mortality. As the number of youth developing T1D and T2D continues to grow, early onset predisposes patients to a longer burden of disease and earlier onset of cardiovascular complications. Early identification and effective management and treatment of risk factors can lead to decreased cardiovascular events and improved quality of life. Read More

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http://dx.doi.org/10.2174/1573396314666180221163924DOI Listing
April 2018
2 Reads

The Essential Role of Primary Caregiver in Early Detection of Familial Hypercholesterolemia and Cardiovascular Prevention.

Curr Pediatr Rev 2017 ;13(4):260-264

Department of Medicine, McGill University, Montreal, Quebec, Canada.

Familial hypercholesterolemia (FH) is a worldwide common autosomal inherited condition associated with premature cardiovascular diseases, both in men and in women (World frequency has been recently estimated to be as high as 1:250). Identifying FH cases early in life could represent a cornerstone to prevent fatal events in adult's life. Pediatricians are well positioned to evaluate the familial cardiovascular risk factors among their young patients, to make a diagnosis and to perform familial screening. Read More

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http://dx.doi.org/10.2174/1573396314666180221162556DOI Listing
April 2018
12 Reads

The Role of Point of Care Ultrasound in the Injured Paediatric Patient.

Curr Pediatr Rev 2018 ;14(1):41-47

Department of Pediatrics, Schulich School of Medicine, Western University, Ontario, ON, Canada.

The focus of this review is to examine the current state of paediatric Point of Care Ultrasound (POCUS) in the injured patient. POCUS has become useful across various medical specialties owing to its ease of use, reproducibility and non-ionizing qualities. Point of care ultrasound has advanced over the past years and has proven to be an extremely useful adjunct in the injured child. Read More

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http://www.eurekaselect.com/159570/article
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http://dx.doi.org/10.2174/1573396314666180202102853DOI Listing
September 2018
7 Reads

Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.

Authors:
Nevim Aygun

Curr Pediatr Rev 2018 ;14(2):73-90

Department of Medical Biology, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey.

Neuroblastoma derived from primitive cells of the sympathetic nervous system typically develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs sporadically, but familial cases are also observed. ALK and PHOX2B germline mutations can cause hereditary neuroblastoma, while a common genetic variation in chromosome 6p22 is associated to sporadic neuroblastoma. Read More

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http://www.eurekaselect.com/159447/article
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http://dx.doi.org/10.2174/1573396314666180129101627DOI Listing
September 2018
12 Reads

Radial Polydactyly. What's New?

Curr Pediatr Rev 2018 ;14(2):91-96

Department of Pediatric Orthopaedic Surgery, Sant Joan de Deu Chidlren's Hospital, Barcelona, Spain.

Background: Thumb duplication, also called radial or preaxial polydactyly, is classified as an alteration of the radio-ulnar axis in the formation and differentiation of the hand plate, according to the Oberg, Manske and Tonkin classification.

Objective: Radial polydactyly is a common upper limb malformation. This paper is a comprehensive analysis of radial polydactyly, its genetic explanation, classification, surgical techniques, functional results, as well as present and future scientific evidence on this congenital pathology. Read More

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http://dx.doi.org/10.2174/1573396314666180124102012DOI Listing
September 2018
6 Reads

Predictors of Non-Alcoholic Liver Disease in Ethnically Diverse Overweight Children and Adolescents.

Curr Pediatr Rev 2018 ;14(2):130-135

Department of Public Health Sciences, University of Miami Miller School of Medicine, United States.

Objectives: To study the relationship between Non-Alcoholic Fatty Liver Disease (NAFLD) and sleep, Physical Activity (PA), and screen-time habits/behaviors among a multiethnic sample of overweight children/adolescents.

Methods: A retrospective medical chart review (6/2013-7/2014) identified 209 patients (7-21 years old) who were overweight/obese (BMI > 85th% for age/sex). A follow-up telephone survey was completed among 130 of these patients' parents to obtain information on sleep, screen-time, PA habits, and socio-demographics. Read More

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http://dx.doi.org/10.2174/1573396314666180124101521DOI Listing
September 2018
2 Reads

Efficacy of Supplementation with Iron Sulfate Compared to Iron Bisglycinate Chelate in Preterm Infants.

Curr Pediatr Rev 2018 ;14(2):123-129

Neonatology and Neonatal Intensive Care Unit, University Hospital, Citta della Salute e della Scienza, Turin, Italy.

Background: Strategies to prevent anaemia in preterm infants include drawing fewer blood samples, the use of recombinant human erythropoietin and iron supplementation. Although iron sulfate is the most commonly used pharmaceutical formulation for iron supplementation, there are few studies comparing different iron salts in infants.

Objective: This is a study of retrospective data comparison of two groups of preterm infants receiving erythropoietin to evaluate the efficacy of iron bisglycinate chelate to iron sulfate. Read More

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http://dx.doi.org/10.2174/1573396314666180124101059DOI Listing
September 2018
6 Reads

Editorial: Neonatal Hyperbilirubinemia.

Authors:
Jon F Watchko

Curr Pediatr Rev 2017 ;13(3):158

Division of Newborn Medicine Department of Pediatrics University of Pittsburgh School of Medicine Magee-Womens Research Institute Pittsburgh, Pennsylvania 15213. 0.

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http://dx.doi.org/10.2174/157339631303180115173857DOI Listing
April 2018
4 Reads

Preface.

Curr Pediatr Rev 2017;13(3):157

Department of Molecular and Developmental Medicine University of Siena Siena. Italy.

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http://dx.doi.org/10.2174/157339631303180115173517DOI Listing
April 2018
4 Reads

Pediatric Markers of Adult Cardiovascular Disease.

Curr Pediatr Rev 2017 ;13(4):255-259

Division of Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, AZ, United States.

Background: Cardiovascular diseases are the leading cause of death worldwide. While cardiovascular disease typically does not occur until adulthood, the pathogenesis of atherosclerotic cardiovascular disease starts in early childhood.

Objective: The purpose of this review is to describe the evidence that the process of atherosclerosis begins in childhood, as well as identify the risk factors present in childhood that are associated with the presence of atherosclerotic cardiovascular disease in childhood as well as future cardiovascular events in adulthood. Read More

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http://dx.doi.org/10.2174/1573396314666180117092010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882498PMC
April 2018
4 Reads

The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project: An 18 Year Review.

Curr Pediatr Rev 2017 ;13(4):265-276

Department of Pediatrics, West Virginia University School of Medicine, WV, United States.

Background: The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project is a chronic disease risk factor surveillance, intervention, and research initiative aimed at combating the unacceptably high prevalence of heart disease, diabetes, and other chronic illnesses in West Virginia.

Objectives And Methods: The school-based public health project identifies health risk factors in children, educates families, informs primary care physicians, and provides resources to schools to help improve population health, beginning with children.

Results And Conclusion: Details regarding methodology, results, and conclusions derived from this unique public health initiative that has screened over 200,000 children are the subject of this 18- year review. Read More

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http://dx.doi.org/10.2174/1573400514666180117093652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944838PMC
April 2018
2 Reads

Hospital Management of Severe Hypertriglyceridemia in Children.

Curr Pediatr Rev 2017 ;13(4):225-231

Department of Pediatrics/Division of Pediatric Endocrinology and Metabolism, Children's of Alabama, University of Alabama at Birmingham, Alabama, United States.

Background: Severe Hypertriglyceridemia (HTG), i.e., plasma triglyceride levels exceeding 1000 mg/dL, is one of the established causes of acute pancreatitis and severe abdominal pain. Read More

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http://dx.doi.org/10.2174/1573400514666180117092707DOI Listing
April 2018
9 Reads