12 results match your criteria Current Organic Synthesis[Journal]

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The Cyanation of Prochiral Aldehydes with Chiral Copper Complexes of R-(+)/S-(-) -α-Ethylphenyl Amine in Methanol.

Authors:
Luo Mei

Curr Org Synth 2016 Jun;13(3):476-482

Department of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P.R. China.

Interesting and unexpected results on the cyanation of prochiral aldehydes catalyzed by chiral copper complexes of R-(+)/(S)-(-) α-ethylphenyl amine () in anhydrous methanol are presented. The cyanation reaction with chiral copper complexes of R-(+)/S-(-) α-ethylphenyl amines, acetols in methanol perform to afford a series of chiral products such as amines and acetonitriles (compounds , , and ). The obtained products are fully characterized by NMR, IR and X-ray analysis. Read More

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http://dx.doi.org/10.2174/157017941303160407000300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427771PMC
June 2016
19 Reads

New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline 
Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities.

Curr Org Synth 2016 Jun;13(3):466-475

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo,Egypt.

A series of new 5-imino-4-thioxo-2-imidazolidinone derivatives with various halogenated and alkylated aromatic substituents at and was synthesized. Imidazolidineiminothione derivatives were prepared from the reaction of arylcyanothioformamide derivatives with aryl isocyanates. These compounds were used as key synthons for the preparation of wide variety of new substituted imidazole compounds. Read More

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http://dx.doi.org/10.2174/1570179412666150817221755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997951PMC
June 2016
15 Reads

The Synthesis of Novel Oxazolinylphosphinic Esters and Amides and Application to the Cyanosilylation of Aldehydes.

Authors:
Mei Luo

Curr Org Synth 2015 Oct;12(5):660-672

Hefei University of Technology, Hefei, Anhui, China, 230009.

A new class of modular functionalized oxazolines are synthesized using a simple, novel one-pot method under inert moisture-free conditions. Then the oxazolines can be further elaborated to phosphine-containing oxazolines. The first step is to synthesize intermediates the reaction of 2 - hydroxybenzonitrile or 2-aminobenzonitrile with chiral amino alcohols, subsequent reactions with phosphine chlorides, providing products in moderate yields. Read More

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http://dx.doi.org/10.2174/157017941205150821153905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388797PMC
October 2015
14 Reads

Syntheses and Functionalizations of Porphyrin Macrocycles.

Curr Org Synth 2014 Feb;11(1):3-28

Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Porphyrin macrocycles have been the subject of intense study in the last century because they are widely distributed in nature, usually as metal complexes of either iron or magnesium. As such, they serve as the prosthetic groups in a wide variety of primary metabolites, such as hemoglobins, myoglobins, cytochromes, catalases, peroxidases, chlorophylls, and bacteriochlorophylls; these compounds have multiple applications in materials science, biology and medicine. This article describes current methodology for preparation of simple, symmetrical model porphyrins, as well as more complex protocols for preparation of unsymmetrically substituted porphyrin macrocycles similar to those found in nature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251786PMC
February 2014
35 Reads

Synthetic Studies of Glycosylphosphatidylinositol (GPI) Anchors and GPI-Anchored Peptides, Glycopeptides, and Proteins.

Authors:
Zhongwu Guo

Curr Org Synth 2013 Jun;10(3):366-383

Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA

Glycosylphosphatidylinositol (GPI) anchorage of proteins and glycoproteins onto the cell surface is ubiquitous in eukaryotes, and GPI-anchored proteins and glycoproteins play an important role in many biological processes. To study GPI anchorage and explore the functions of GPIs and GPI-anchored proteins and glycoproteins, it is essential to have access to these molecules in homogeneous and structurally defined forms. This review is focused on the progress that our laboratory has made towards the chemical and chemoenzymatic synthesis of structurally defined GPI anchors and GPI-anchored peptides, glycopeptides, and proteins. Read More

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http://dx.doi.org/10.2174/1570179411310030003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063365PMC
June 2013
22 Reads

Molecular Imaging Probe Development using Microfluidics.

Curr Org Synth 2011 Aug;8(4):473-487

College of Electronics and Information Engineering, Wuhan Textile University, Wuhan, 430073, China.

In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidic-based probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Read More

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http://dx.doi.org/10.2174/157017911796117205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439210PMC
August 2011
30 Reads

Strategies for the preparation of bifunctional gadolinium(III) chelators.

Curr Org Synth 2011 Aug;8(4):535-565

Case Western Reserve University. 11100 Euclid Ave Cleveland, OH 44106.

The development of gadolinium chelators that can be easily and readily linked to various substrates is of primary importance for the development high relaxation efficiency and/or targeted magnetic resonance imaging (MRI) contrast agents. Over the last 25 years a large number of bifunctional chelators have been prepared. For the most part, these compounds are based on ligands that are already used in clinically approved contrast agents. Read More

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http://dx.doi.org/10.2174/157017911796117250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286626PMC
August 2011
11 Reads

Molecular Imaging of Hypoxia: Strategies for Probe Design and Application.

Curr Org Synth 2011 Aug;8(4):593-603

Molecular Imaging Program at Stanford (MIPS), Department of Radiation of Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed. Read More

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http://dx.doi.org/10.2174/157017911796117179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279754PMC
August 2011
10 Reads

Radiolabeled oligonucleotides for antisense imaging.

Curr Org Synth 2011 Aug;8(4):604-614

Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143.

Oligonucleotides radiolabeled with isotopes emitting γ-rays (for SPECT imaging) or positrons (for PET imaging) can be useful for targeting messenger RNA (mRNA) thereby serving as non-invasive imaging tools for detection of gene expression in vivo (antisense imaging). Radiolabeled oligonucleotides may also be used for monitoring their in vivo fate, thereby helping us better understand the barriers to its delivery for antisense targeting. These developments have led to a new area of molecular imaging and targeting, utilizing radiolabeled antisense oligonucleotides. Read More

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http://dx.doi.org/10.2174/157017911796117241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148791PMC
August 2011
10 Reads

NEAR-INFRARED DYES: Probe Development and Applications in Optical Molecular Imaging.

Curr Org Synth 2011 Aug;8(4):521-534

Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21 Avenue South, Medical Center North, AA-1105, Nashville, TN 37232-2310.

The recent emergence of optical imaging has brought forth a unique challenge for chemists: development of new biocompatible dyes that fluoresce in the near-infrared (NIR) region for optimal use in biomedical applications. This review describes the synthesis of NIR dyes and the design of probes capable of noninvasively imaging molecular events in small animal models. Read More

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http://dx.doi.org/10.2174/157017911796117223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150548PMC
August 2011
10 Reads

Activatable Optical Probes for the Detection of Enzymes.

Curr Org Synth 2011 Aug;8(4):498-520

Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA, 94107, USA.

The early detection of many human diseases is crucial if they are to be treated successfully. Therefore, the development of imaging techniques that can facilitate early detection of disease is of high importance. Changes in the levels of enzyme expression are known to occur in many diseases, making their accurate detection at low concentrations an area of considerable active research. Read More

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http://dx.doi.org/10.2174/157017911796117232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601828PMC
August 2011
17 Reads

Aza-[3 + 3] Annulations: A New Unified Strategy in Alkaloid Synthesis.

Curr Org Synth 2010 Aug;7(4):363-401

Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705.

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http://dx.doi.org/10.2174/157017910791414490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949981PMC
August 2010
10 Reads
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