754 results match your criteria Current Opinion in Supportive and Palliative Care[Journal]


Mindfulness-based interventions for cancer-related pain and depression: a narrative review of current evidence and future potential.

Curr Opin Support Palliat Care 2019 Apr 9. Epub 2019 Apr 9.

Adult Psychological Support Service, Royal Marsden Hospital, Downs Road, Sutton, UK.

Purpose Of Review: People with cancer commonly experience persistent pain and psychological distress. Interventions are needed which address the multifactorial nature of pain and depression, yet few studies have examined the impact of mindfulness-based interventions (MBIs) for cancer-related pain and depression.

Recent Findings: MBIs for cancer-related pain and depression can be effectively delivered across a range of modalities and show promise for alleviating mood and some physical health symptoms, although not always pain. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9939
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http://dx.doi.org/10.1097/SPC.0000000000000428DOI Listing
April 2019
4 Reads

Opioids and breast cancer recurrence.

Curr Opin Support Palliat Care 2019 Mar 28. Epub 2019 Mar 28.

Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.

Purpose Of Review: Breast cancer survival has improved motivating the need for better understanding of the sequelae of the disease and its treatments. Lab studies suggest opioids modify cancer cell growth but the association of opioids with cancer progression in humans is not clear. This review aims to summarize recent findings related to opioid use and breast cancer progression. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000426DOI Listing
March 2019
1 Read

Methods of assessing late radiotherapy effects on bowel function.

Curr Opin Support Palliat Care 2019 Mar 28. Epub 2019 Mar 28.

Division of Cancer and Genetics, School of Medicine, Cardiff University and Velindre University NHS Trust, Cardiff, UK.

Purpose Of Review: Pelvic radiation disease in the form of chronic radiation-induced consequences of treatment is under recognized by healthcare professionals and under reported by patients. Gastrointestinal symptoms are not routinely assessed, and may not be causally associated with previous radiotherapy. These symptoms are therefore often under treated. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000422DOI Listing

Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets.

Curr Opin Support Palliat Care 2019 Mar 28. Epub 2019 Mar 28.

NNF Center of Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Purpose Of Review: Mucositis remains a prevalent, yet poorly managed side effect of anticancer therapies. Mucositis affecting both the oral cavity and gastrointestinal tract predispose to infection and require extensive supportive management, contributing to the growing economic burden associated with cancer care. Animal models remain a critical aspect of mucositis research, providing novel insights into its pathogenesis and revealing therapeutic targets. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000421DOI Listing

Intrathecal therapy for pain in cancer patients.

Authors:
Denis Dupoiron

Curr Opin Support Palliat Care 2019 Mar 20. Epub 2019 Mar 20.

Anesthesiology and Pain Department, Institut de Cancérologie de l'Ouest, Paul Papin, Angers Cedex, France.

Purpose Of Review: Intrathecal drug delivery systems (IDDS) for cancer pain remain little employed despite a high level of efficiency even though the technique is widely recommended. This review aims to summarize recent advances in IDDS for cancer patients.

Recent Findings: The respective roles of catheter positioning, volume and flow rate in diffusion of intrathecal treatments, as well as the individual roles of blood pressure, heart rate, and amplitude of the respiratory movements in cerebrospinal fluid (CSF) treatment dispersion, are now well established. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000427DOI Listing
March 2019
1 Read

The role of mucins in mucositis.

Authors:
Daniel Thorpe

Curr Opin Support Palliat Care 2019 Mar 18. Epub 2019 Mar 18.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.

Purpose Of Review: Alimentary mucositis is a severe dose limiting side effect of chemotherapy and radiotherapy. Mucin expression and secretion are associated with mucositis. This article aims to review current studies involving mucin and mucositis. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000423DOI Listing
March 2019
5 Reads

Where has the 'bio' in bio-psycho-social gone?

Curr Opin Support Palliat Care 2019 Mar 18. Epub 2019 Mar 18.

Integrative Spinal Research Group, Department of Chiropractic Medicine, University Hospital Balgrist and University of Zurich, Zurich, Switzerland.

Purpose Of Review: Current definitions of pain do not necessitate tissue damage. This is important because it does justice to the pain patient in whom a nociceptive source is not detectable. However, in conjunction with exciting findings regarding supraspinal pain modulation and a (perceived) failure of identifying nociceptive sources in individual patients, this might have led to a devaluation of the role of nociception for chronic pain. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000420DOI Listing
March 2019
6 Reads

Knowledge of gastrointestinal toxicity mechanisms is paving the way for improved assessment and management of patient supportive care.

Curr Opin Support Palliat Care 2019 Mar 14. Epub 2019 Mar 14.

Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SPC.0000000000000424DOI Listing

Issues in the future development of new analgesic drugs.

Curr Opin Support Palliat Care 2019 Mar 14. Epub 2019 Mar 14.

Biosciences Division, Department of Neuroscience, Pharmacology and Physiology, University College London, London, UK.

Purpose Of Review: There is a clear unmet need for either the development of new drugs for the treatment of painful pathologies or the better use of the existing agents denoted by the lack of efficacy of many existing drugs in a number of patients, limitations of their use due to severity of side effects, and by the high number of drugs that fail to reach clinical efficacy from preclinical development. This account considers the efforts being made to better validate new analgesic components and to improve translational efficacy of existing drugs.

Recent Findings: A better use of the available models and tools can improve the predictive validity of new analgesic drugs, as well as using intermediate steps when translating drugs to clinical context such as characterizing drugs using stem cell-sensory derived neurones. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000425DOI Listing

Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression.

Curr Opin Support Palliat Care 2019 Mar 6. Epub 2019 Mar 6.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.

Purpose Of Review: The purpose of this review is to summarize recent findings on conditioned pain modulation (CPM) in humans with a focus on methodology, factors modulating CPM, and the potential for CPM as a clinical marker for pain progression.

Recent Findings: CPM can be evoked by combining different stimulus modalities with good reliability; sequential CPM effects are stable over time with limited carryover effects. Optimism and pain catastrophizing might influence pain inhibition. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000419DOI Listing
March 2019
1 Read

Best practices on team communication: interprofessional practice in oncology.

Curr Opin Support Palliat Care 2019 03;13(1):69-74

Practice Based Research and Innovation, Sunnybrook Health Sciences Centre.

Purpose Of Review: Good communication is the cornerstone of interprofessional care teams providing optimized quality patient care. Over the last decade, advances in technology have provided tools to improve communication; however, opportunities still exist for innovation and implementation.

Recent Findings: The literature suggests that interprofessional education and assessment of team communication are fundamental in supporting collaborative care. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000412DOI Listing
March 2019
6 Reads

The role of splanchnic congestion and the intestinal microenvironment in the pathogenesis of advanced heart failure.

Curr Opin Support Palliat Care 2019 03;13(1):24-30

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose Of Review: Right-sided heart failure, which is often present in the setting of advanced heart failure, is associated with cardiac cachexia, the cardiorenal syndrome, and adverse outcomes. Improved understanding of venous congestion of the splanchnic circulation, which may play a key role in the pathogenesis of right-sided heart failure, could lead to novel therapeutics to ameliorate heart failure. Here we provide an overview of right-sided heart failure, splanchnic hemodynamics, fluid homeostasis, and the intestinal microenvironment. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366455PMC
March 2019
1 Read

Communication in cancer: its impact on the experience of cancer care: communicating with the angry patient and the patient in denial.

Curr Opin Support Palliat Care 2019 03;13(1):46-52

Sacred Heart Health Service, St Vincent's Hospital, Sydney.

Purpose Of Review: This review aims to describe the recent literature on communication between cancer care clinicians and angry patients and patients in denial.

Recent Findings: Clinicians had improved perceived self-efficacy in responding to patient anger after completing anger management training, with a focus on reframing anger as a normative response to unmet needs. Psychosocial and mindfulness programmes for cancer patients were found to be useful for modifying anger response to stressors. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000410DOI Listing
March 2019
2 Reads

Cancer and fertility: optimizing communication between patients and healthcare providers.

Curr Opin Support Palliat Care 2019 03;13(1):53-58

Lady Davis Institute for Medical Research, Jewish General Hospital and McGill University, Montreal, Quebec, Canada.

Purpose Of Review: This article reviews the status of guidelines and recommendations for communication between patients with cancer and healthcare providers (HCPs) concerning fertility issues.

Recent Findings: The timing, the type of information provided, and the openness of HCPs can all affect how patients with cancer perceive discussions regarding fertility concerns and preservation. In addition, whether such discussions occur is associated with intrinsic factors, such as age and sex of the patients as well as HCP's knowledge level. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000413DOI Listing
March 2019
12 Reads

Editorial: Communication in cancer.

Curr Opin Support Palliat Care 2019 03;13(1):31-32

Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/SPC.0000000000000416DOI Listing
March 2019
1 Read

Editorial: Culture, treatment paradigms, and advanced heart failure.

Authors:
James M Beattie

Curr Opin Support Palliat Care 2019 03;13(1):1-2

Cicely Saunders Institute, King's College London, London, UK.

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http://dx.doi.org/10.1097/SPC.0000000000000415DOI Listing
March 2019
2 Reads

Oncologists communicating with patients about assisted dying.

Curr Opin Support Palliat Care 2019 03;13(1):59-63

Sunnybrook Health Sciences Centre.

Purpose Of Review: Across all jurisdictions in which assisted dying is legally permissible, cancer is the primary reported underlying diagnosis. Therefore, oncologists are likely to be asked about assisted dying and should be equipped to respond to inquiries or requests for assisted dying. Because Medical Assistance in Dying was legalized in Canada in 2016, it is a relatively new end-of-life practice and has prompted the need to revisit the academic literature to inform communication with patients about assisted dying. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000411DOI Listing
March 2019
1 Read

Communication involving special populations: older adults with cancer.

Curr Opin Support Palliat Care 2019 03;13(1):64-68

Division of Geriatrics and Palliative Medicine, Weill Medical College of Cornell University, New York.

Purpose Of Review: Cancer has a high incidence and death rate among older adults. The objective of this article is to summarize current literature about communication between older adults and medical professionals in cancer care. Our article addresses four categories related to communication: first, ageism; second, screening; third, treatment; and fourth, end of life (EoL) care. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000408DOI Listing
March 2019
2 Reads

Communication skills training for healthcare professionals in oncology over the past decade: a systematic review of reviews.

Curr Opin Support Palliat Care 2019 03;13(1):33-45

Amsterdam UMC, University of Amsterdam, Medical Psychology.

Purpose Of Review: Effective communication in cancer care requires complex communication skills of healthcare professionals (HCPs), which can be advanced by communication skills training (CST). The number of empirical studies on CST has grown steadily over the last decade. However, controversies on CST abound. Read More

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http://Insights.ovid.com/crossref?an=01263393-201903000-0000
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http://dx.doi.org/10.1097/SPC.0000000000000409DOI Listing
March 2019
2 Reads

Can a complex adaptive systems perspective support the resiliency of the heart failure patient - informal caregiver dyad?

Curr Opin Support Palliat Care 2019 03;13(1):9-13

Centre for Health Education Scholarship, Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.

Purpose Of Review: A holistic palliative approach for heart failure care emphasizes supporting nonprofessional informal caregivers. Informal caregivers play a vital role caring for heart failure patients. However, caregiving negatively affects informal caregivers' well being, and in turn heart failure patients' health outcomes. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000406DOI Listing
March 2019
3 Reads

Structural heart disease: one valve does not fit all.

Curr Opin Support Palliat Care 2019 03;13(1):14-17

University Hospitals Cleveland Medical Center/Harrington Heart & Vascular Institute, Cleveland, Ohio, USA.

Purpose Of Review: Highlight the difficulties patients, physicians, and the global economy face in relation to treatment of structural heart diseases. It is easy to be carried away by the excitement of medical advancement; however, it is difficult to demonstrate restraint. Transcatheter aortic valve replacement (TAVR) is a modern marvel that can help many patients when utilized appropriately. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000407DOI Listing
March 2019
21 Reads

The lived experience of breathlessness for people diagnosed with heart failure: a qualitative synthesis of the literature.

Curr Opin Support Palliat Care 2019 03;13(1):18-23

College of Nursing, East Carolina University, Greenville, North Carolina, USA.

Purpose Of Review: The experience of breathlessness in patients with heart failure is understudied. This review was aimed at evaluating the most recent qualitative findings regarding the experience of breathlessness in persons diagnosed with heart failure.

Recent Findings: A literature search was conducted using Pubmed, Psycinfo, BNI, Cinahl and Google Scholar including studies on breathlessness experience in patients with heart failure, published between 2017 and 2018. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000405DOI Listing
March 2019
1 Read

Māori: living and dying with cardiovascular disease in Aotearoa New Zealand.

Curr Opin Support Palliat Care 2019 03;13(1):3-8

School of Nursing, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Purpose Of Review: This article provides an informed perspective on cardiovascular disease (CVD) and palliative care need among Māori New Zealanders. High Māori CVD risk factors will contribute to a sharp increase in older Māori deaths which has implications for health and palliative care service provision.

Recent Findings: CVD is New Zealand's leading cause of premature deaths and disability among Māori. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9941
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http://dx.doi.org/10.1097/SPC.0000000000000404DOI Listing
March 2019
10 Reads

Nutrition support for treating cancer-associated weight loss: an update.

Curr Opin Support Palliat Care 2018 12;12(4):434-438

Department of Clinical Medicine, Sapienza University of Rome, Italy.

Purpose Of Review: Patients with cancer present high risk for involuntary body weight loss and reduced food intake, which, contributing to progressive tissue wasting and affecting the nutritional status, are often under-estimated in the clinical practice. In this article, we aimed at focusing on cancer-associated weight loss and investigating recent evidences on the indications of nutritional interventions to treat this condition.

Recent Findings: During the last few years, increased emphasis has been addressed on the mechanisms underlying body weight loss in cancer that can be induced by either cancer metabolism and inflammation, either several side-effects of the anticancer treatments. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000383DOI Listing
December 2018
7 Reads

Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes.

Curr Opin Support Palliat Care 2018 12;12(4):404-409

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW, Australia.

Purpose Of Review: To review recent finding on MIC-1/GDF15 and re-evaluate it as a potential target for the therapy of anorexia/cachexia syndromes.

Recent Findings: MIC-1/GDF15 consistently induces anorexia/cachexia in animal models. Its actions on brainstem feeding centers leads to anorexia, inducing prolonged undernutrition and consequent loss of both lean and fat mass. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000384DOI Listing
December 2018
4 Reads

Hemato-oncology and palliative care teams: is it time for an integrated approach to patient care?

Curr Opin Support Palliat Care 2018 12;12(4):530-537

Massachusetts General Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Integrated palliative care for those with advanced solid tumors yields significant benefits in patient and caregiver outcomes. However, most palliative care clinical trials have excluded patients with hematologic malignancies. There is growing interest in whether integrated palliative care may yield similar benefits in hematologic malignancy patients and caregivers, but there has been little direct evidence of benefit in this population. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000385DOI Listing
December 2018
1 Read

Instruments to evaluate complexity in end-of-life care.

Curr Opin Support Palliat Care 2018 12;12(4):480-488

Palliative Care Department, University of Munich, Munich, Germany.

Purpose Of Review: The growing number of patients with terminal and chronic conditions and co-morbidities constitutes a challenge for any healthcare system, to provide effective and efficient patient-centred care at the end of life. Resources are limited, and complexity is rising within patients' situations and healthcare professionals interventions. This review presents the state of art of the role of complexity in specialist palliative care provision. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000403DOI Listing
December 2018
26 Reads

'The shoulders, clavicles, chest and thighs melt away': a compilation of reviews on cachexia.

Curr Opin Support Palliat Care 2018 12;12(4):393

Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1097/SPC.0000000000000399DOI Listing
December 2018
5 Reads

Targeting IL-1α in cancer cachexia: a narrative review.

Curr Opin Support Palliat Care 2018 12;12(4):453-459

Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh.

Purpose Of Review: Cachexia is defined as ongoing loss of skeletal muscle mass, with or without depletion of adipose tissue and is a common syndrome in cancer patients, affecting 50% of those diagnosed. Cachexia, which cannot be fully reversed and causes significant functional impairment is caused by various mechanisms such as an altered energy balance and disruption of homeostatic control by the central nervous system. This central nervous system deregulation involves hypothalamic pituitary adrenal (HPA) axis stimulation, which can be triggered by IL-1R1 engagement on neuronal processes and endothelium in the microvasculature of the hypothalamus. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9942
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http://dx.doi.org/10.1097/SPC.0000000000000398DOI Listing
December 2018
2 Reads

The role of day care in supporting older people living with long-term conditions.

Curr Opin Support Palliat Care 2018 12;12(4):510-515

Academic Palliative and Supportive Care Studies Group (APSCSG), University of Liverpool, Brownlow Hill, Liverpool, England.

Purpose Of Review: For older people with long-term conditions, regular structured activities within a community setting meeting others are thought to improve well being and quality of life. Historically local authority-run day care centres were widely available, but austerity measures have meant that in many areas, such provision has been markedly reduced and different models of day care services are being developed. There is little known about outcomes of day care provision for older people with long-term conditions. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9942
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http://dx.doi.org/10.1097/SPC.0000000000000391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221434PMC
December 2018
2 Reads

Palliative care teaching shapes medical undergraduate students' professional development: a scoping review.

Curr Opin Support Palliat Care 2018 12;12(4):495-503

ATLANTES Research Programme, Institute for Culture and Society (ICS), University of Navarra.

Purpose Of Review: The aim of this review is to understand how palliative care teaching (PCT) as a patient-centered learning model, influences medical undergraduate students' professional development.

Recent Findings: To study PCT medical undergraduate students' learning experiences, we have employed the medical teaching concept, 'hidden curriculum,' as a way of describing attitudes and behavior conveyed implicitly by palliative care educators. Fifteen studies were selected: ten of those studies used a qualitative approach; two are theoretical explanations of the topic explored, one guideline, one review and just one quantitative study, made up the review. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000402DOI Listing
December 2018
2 Reads

Compassion in palliative care: a review.

Curr Opin Support Palliat Care 2018 12;12(4):472-479

New Health Foundation, Sevilla, Spain.

Purpose Of Review: Compassion has been recognized as a key aspect of high-quality healthcare, particularly in palliative care. This article provides a general review of the current understanding of compassion in palliative care and summarizes emergent compassionate initiatives in palliative care at three interdependent levels: compassion for patients, compassion in healthcare professionals, and compassionate communities at the end of life.

Recent Findings: Compassion is a constructive response to suffering that enhances treatment outcomes, fosters the dignity of the recipient, and provides self-care for the giver. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9941
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http://dx.doi.org/10.1097/SPC.0000000000000393DOI Listing
December 2018
3 Reads

Technology for improving accessibility of end-of-life care: Extension for Community Healthcare Outcomes Project.

Curr Opin Support Palliat Care 2018 12;12(4):466-471

Hospital Maciel Palliative Care Service - Medical School, Universidad de la República, Montevideo, Uruguay.

Purpose Of Review: To describe how Project ECHO works and to analyze what has been published on Project ECHO Palliative Care (Project ECHO PC) over the last 18 months.

Recent Findings: Only two articles on Project ECHO PC have been published over the last 18 months: a descriptive study of experiences in seven health centers of the United States, the United Kingdom, Uruguay and India; and a quantitative and qualitative study of the impact of the teleECHO clinic on physicians and nurses in Northern Ireland, which reports a significant boost in knowledge acquisition and self-efficacy.

Summary: Project ECHO is an innovative telemedicine strategy, which creates learning communities, which use a standardized methodology and benefits healthcare professionals, particularly primary care providers or practitioners based on remote or rural areas. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9941
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http://dx.doi.org/10.1097/SPC.0000000000000390DOI Listing
December 2018
3 Reads

Predictors of reliably high-value end-of-life care.

Curr Opin Support Palliat Care 2018 12;12(4):460-465

Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai.

Purpose Of Review: Care near the end of life is expensive and frequently not aligned with the expressed preferences of decedents, creating an opportunity to improve value, or increase quality while lowering cost. This review examines publications from 2017 and 2018 on interventions and policies associated with high-value end-of-life care. Innovations in video and web-based advance care planning are promising to improve preference-congruent care at low cost. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9941
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http://dx.doi.org/10.1097/SPC.0000000000000392DOI Listing
December 2018
2 Reads

Managing anaemia in bone marrow failure syndromes.

Curr Opin Support Palliat Care 2018 12;12(4):538-541

Department of Haematology, University Hospital Southampton NHSFT, Shirley, Southampton, England.

Purpose Of Review: Anaemia is a common haematological presentation in patients with bone marrow failure, yet a challenging condition to treat. As anaemia has a direct impact on the patient's symptoms, managing anaemia in the common bone marrow failure conditions, such as myelodysplastic syndrome will help to improve the quality of life. This review discusses the available treatment options and the benefit of improving the haemoglobin level. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000397DOI Listing
December 2018
7 Reads

Endpoints in clinical trials in cancer cachexia: where to start?

Curr Opin Support Palliat Care 2018 12;12(4):445-452

European Palliative Care Research Centre (PRC), Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology.

Purpose Of Review: The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and mortality. An endpoint should both be sensitive enough to detect change and specific enough not to be influenced by other conditions or treatments.

Recent Findings: There is a wealth of potential and applied endpoints in trials investigating cachexia. Read More

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http://Insights.ovid.com/crossref?an=01263393-900000000-9942
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http://dx.doi.org/10.1097/SPC.0000000000000387DOI Listing
December 2018
2 Reads

Psychological burden of haematological cancer on patient and family: is it time for a multisystem approach?

Curr Opin Support Palliat Care 2018 12;12(4):518-521

Hospital Palliative Care Team, University Hospital Southampton, Southampton, UK.

Purpose Of Review: Literature addressing the psychological impact of haematological cancers on patients and their families is sparse. New evidence might prompt a change in approach to the assessment and management of psychological burden.

Recent Findings: The diagnosis, treatment and surveillance of haematological cancers often have a profound psychological impact on patients and their families and can result in clinically significant problems and increased carer stress. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000396DOI Listing
December 2018
18 Reads

We all need support but can our patients help us to help them?

Curr Opin Support Palliat Care 2018 12;12(4):516-517

Department of Haematology, University Hospital Southampton (NHS Foundation Trust), Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1097/SPC.0000000000000389DOI Listing
December 2018
2 Reads

How should we assess patient-reported outcomes in the onco-hematology clinic?

Curr Opin Support Palliat Care 2018 12;12(4):522-529

Innsbruck Institute of Patient-centered Outcome Research (IIPCOR), Innsbruck, Austria.

Purpose Of Review: The improvement of clinical outcomes in hematologic malignancies has paved the way for a more systematic patient-reported outcomes (PROs) assessment in routine clinical practice. PROs help to narrow the gap between patients' and healthcare professionals' view of patient health and treatment success. This review outlines key aspects of planning and performing PRO assessments in daily routine such as the selection of PRO instruments, electronic PRO data collection, and the presentation and interpretation of PRO results. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000386DOI Listing
December 2018
1 Read

Palliative care for all? How can Brazil develop a palliative care service founded on principles of equity and access for all?

Curr Opin Support Palliat Care 2018 12;12(4):504-509

Compassionate Communities.

Purpose Of Review: Despite the historical international development of palliative care over the last 50 years, provision of equity of care and access to appropriate medication remains a major problem in many countries across the world. Interest in the public health approach to end-of-life care has grown over the last 20 years. Models of palliative care, which are affordable and provide equity of care are changing through these new concepts. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000394DOI Listing
December 2018
11 Reads

What's next in using CT scans to better understand cachexia?

Curr Opin Support Palliat Care 2018 12;12(4):427-433

Biostatistics and Epidemiology Unit, Gustave Roussy Cancer Campus.

Purpose Of Review: Cachexia (CAX), a protein metabolism disorder commonly associated with cancer, can be evaluated by computed tomography (CT) scan assessment of skeletal muscle mass (SMM), a parameter associated with patient outcome. This review analyzes current barriers for using CT scans of SMM in routine management for defining prognostic risk groups, and proposes new areas of research to reach a better understanding of CAX mechanisms.

Recent Findings: Current research is focused on establishing a robust and relevant CAX staging system to reach a consensual definition. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000388DOI Listing
December 2018
26 Reads

Benzodiazepines for agitation in patients with delirium: selecting the right patient, right time, and right indication.

Authors:
David Hui

Curr Opin Support Palliat Care 2018 12;12(4):489-494

Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, USA.

Purpose Of Review: To provide an evidence-based synopsis on the role of benzodiazepines in patients with agitated delirium.

Recent Findings: Existing evidence supports the use of benzodiazepines in two specific delirium settings: persistent agitation in patients with terminal delirium and delirium tremens. In the setting of terminal delirium, the goal of care is to maximize comfort, recognizing that patients are unlikely to recover from their delirium. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261485PMC
December 2018
5 Reads

The relationship between muscle mass and function in cancer cachexia: smoke and mirrors?

Curr Opin Support Palliat Care 2018 12;12(4):439-444

Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Purpose Of Review: Randomized clinical trials of cancer cachexia interventions are based on the premise that an increase in the muscle mass of patients is associated with consequent improvements in muscle function, and ultimately, quality of life. However, recent trials that have succeeded in demonstrating increases in lean body mass have been unable to show associated increases in patient physical function. In this review, we examine the potential causes for this lack of association between muscle mass and function in cancer cachexia, paying particular attention to those factors that may be at play when using body composition analysis techniques involving cross-sectional imaging. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000381DOI Listing
December 2018
1 Read

How much does reduced food intake contribute to cancer-associated weight loss?

Curr Opin Support Palliat Care 2018 12;12(4):410-419

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

Purpose Of Review: An international consensus group defined cancer cachexia as a syndrome of involuntary weight loss, characterized by loss of skeletal muscle (with or without fat loss), which is driven by a variable combination of reduced food intake and altered metabolism.This review presents recent studies that evaluated the contribution of reduced food intake to cancer-associated weight loss.

Recent Findings: Four studies examined food intake in relation to weight loss. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000379DOI Listing
December 2018
1 Read

Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition.

Curr Opin Support Palliat Care 2018 12;12(4):420-426

Department of Anatomy and Cell Biology.

Purpose Of Review: Cancer patients undergoing chemotherapy often experience very debilitating side effects, including unintentional weight loss, nausea, and vomiting. Changes in body composition, specifically lean body mass (LBM), are known to have important implications for anticancer drug toxicity and cancer prognosis. Currently, chemotherapy dosing is based on calculation of body surface area, although this approximation does not take into consideration the variability in lean and adipose tissue mass. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221433PMC
December 2018
16 Reads

Understanding sex differences in the regulation of cancer-induced muscle wasting.

Curr Opin Support Palliat Care 2018 12;12(4):394-403

Department of Exercise Science, University of South Carolina, Public Health Research Center, Columbia, USA.

Purpose Of Review: We highlight evidence for sexual dimorphism in preclinical and clinical studies investigating the cause and treatment of cancer cachexia.

Recent Findings: Cancer cachexia is unintended bodyweight loss occurring with cancer, and skeletal muscle wasting is a critical predictor of negative outcomes in the cancer patient. Skeletal muscle exhibits sexual dimorphism in fiber type, function, and regeneration capacity. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239206PMC
December 2018
3 Reads

Improving outcome in patients with prostate and kidney cancer: heading in the right direction?

Authors:
Fred Saad

Curr Opin Support Palliat Care 2018 09;12(3):323-324

Centre Hospitalier de l'Université de Montreal, Montreal Cancer Institute/CRCHUM, Montreal, Canada.

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http://dx.doi.org/10.1097/SPC.0000000000000368DOI Listing
September 2018
2 Reads

Psychological support for patients with cancer: evidence review and suggestions for future directions.

Curr Opin Support Palliat Care 2018 09;12(3):276-292

Centre for Medical Psychology & Evidence-based Decision Making, School of Psychology, University of Sydney, Sydney, New South Wales, Australia.

Purpose Of Review: Psychological distress and mental health comorbidity are common in cancer. Various therapeutic frameworks have been used for interventions to improve psychological wellbeing and quality of life in cancer patients with mixed results. This article reviews contributions to that literature published since January 2017. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000360DOI Listing
September 2018
9 Reads

The role of primary care in supporting patients living with and beyond cancer.

Curr Opin Support Palliat Care 2018 09;12(3):261-267

School of Nursing and Midwifery, Faculty Health and Life Sciences, University of Oxford, Oxford, UK.

Purpose Of Review: The prevalence of cancer survivors is increasing. Those living with and beyond a cancer diagnosis have a range of physical, psychosocial and practical needs. This review aims to discuss the role of primary care in meeting these needs. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000369DOI Listing
September 2018
25 Reads

Pathophysiological mechanisms of exertional breathlessness in chronic obstructive pulmonary disease and interstitial lung disease.

Curr Opin Support Palliat Care 2018 09;12(3):237-245

Department of Physical Therapy, University of British Columbia.

Purpose Of Review: Breathlessness is a common and distressing symptom in patients with chronic obstructive pulmonary disease (COPD) and fibrotic interstitial lung disease (ILD), particularly during exercise. Effective medical management of exertional breathlessness in people living with COPD and fibrotic ILD is challenging for healthcare providers and requires an understanding of its mechanisms. Thus, in this brief review we summarize recent advances in our understanding of the pathophysiological mechanisms of exertional breathlessness in COPD and fibrotic ILD. Read More

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http://dx.doi.org/10.1097/SPC.0000000000000377DOI Listing
September 2018
20 Reads