3,130 results match your criteria Current Opinion in Rheumatology[Journal]


Cryptic conspirators: a conversation about thrombocytopenia and antiphospholipid syndrome.

Curr Opin Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Purpose Of Review: Although antiphospholipid syndrome (APS) is best known for conveying increased risk of thrombotic events and pregnancy morbidity, thrombocytopenia is also recognized as a common association. In this review, we will explore the relationship between thrombocytopenia and APS, highlighting our evolving understanding - and persistent knowledge gaps - through clinically oriented questions and answers.

Recent Findings: A history of thrombocytopenia likely portends a more severe APS phenotype (including increased risk of thrombosis). Read More

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http://dx.doi.org/10.1097/BOR.0000000000000595DOI Listing
February 2019
1 Read

Patient preferences for rheumatoid arthritis treatment.

Curr Opin Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Yale University School of Medicine, New Haven.

Purpose Of Review: To provide an overview of recent articles discussing patient preferences for rheumatoid arthritis (RA) treatment.

Recent Findings: Recent studies examined patient preferences for RA treatment in several populations, finding that most participants were willing to accept certain risks of adverse effects to gain potential benefits. Perspectives regarding cannabis were studied, with patients describing medical marijuana as an alternative therapy to be used with prescription medications or as means of tapering off these medications. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000591DOI Listing
February 2019
1 Read

Gene-function studies in systemic lupus erythematosus.

Curr Opin Rheumatol 2019 Mar;31(2):185-192

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.

Purpose Of Review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

Recent Findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000572DOI Listing
March 2019
1 Read

The microbiome in systemic autoimmune disease: mechanistic insights from recent studies.

Curr Opin Rheumatol 2019 Mar;31(2):201-207

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: The resident bacterial communities and the host immune system have coevolved for millennia. However, recent changes in modern societies have disrupted this coevolutionary homeostasis and contributed to a rise in immune-mediated conditions. The purpose of this review is to provide an overview of recently elucidated mechanisms of how certain taxa within the bacterial microbiome propagate autoimmunity. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000574DOI Listing
March 2019
9 Reads

Measuring outcomes in ankylosing spondylitis: pearls and pitfalls.

Curr Opin Rheumatol 2019 Mar;31(2):109-117

Allergy, Immunology Division, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.

Purpose Of Review: Patients with ankylosing spondylitis (AS) warrant a comprehensive clinical assessment because of the lack of biomarkers of disease activity, prognosis and response to biologic therapy. Multiple AS-related questionnaires have been developed to assess the disease status accurately, but feasibility remains a problem in clinical practice. The purpose of this review is to assess the pearls and pitfalls of AS-related outcome measures. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000588DOI Listing
March 2019
3 Reads

Methods for measuring patient preferences: an update and future directions.

Curr Opin Rheumatol 2019 Mar;31(2):125-131

Department of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Purpose Of Review: The current review highlights the growing number of available methods used to measure patient preferences and discusses how this impacts preference research in rheumatology. Spurred by the growing role of preferences in regulatory decisions and drug development, researchers have begun applying preference methods to study questions beyond the clinical context. We explore these trends, provide case studies highlighting changes in measuring patient preferences, compare strengths and weaknesses of common stated-preference methods, and discuss considerations for the future use of these methods. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000587DOI Listing
March 2019
1 Read

Quality improvement initiatives in rheumatology: an integrative review of the last 5 years.

Curr Opin Rheumatol 2019 Mar;31(2):98-108

Division of Rheumatology, Department of Medicine, University of California, San Francisco, California, USA.

Purpose Of Review: We reviewed recent quality improvement initiatives in the field of rheumatology to identify common strategies and themes leading to measurable change.

Recent Findings: Efforts to improve quality of care in rheumatology have accelerated in the last 5 years. Most studies in this area have focused on interventions to improve process measures such as increasing the collection of patient-reported outcomes and vaccination rates, but some studies have examined interventions to improve health outcomes. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000586DOI Listing
March 2019
8 Reads

Editorial: Updates in crystal deposition diseases.

Authors:
Sara K Tedeschi

Curr Opin Rheumatol 2019 Mar;31(2):132-133

Brigham and Women's Hospital, Division of Rheumatology, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000581DOI Listing
March 2019
1 Read

The vitamin D and calcium controversy: an update.

Curr Opin Rheumatol 2019 Mar;31(2):91-97

Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Melbourne, Australia.

Purpose Of Review: Calcium and vitamin D supplementation is widely recommended for prevention of falls and fracture, particularly in the elderly where calcium intakes and vitamin D levels are often inadequate. A number of meta-analyses have questioned the benefits of untargeted or 'holistic' supplementation for falls and fracture, and raised the possibility of adverse cardiovascular effects. This review provides an update on these controversies. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000584DOI Listing
March 2019
9 Reads

Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.

Curr Opin Rheumatol 2019 Mar;31(2):134-143

Purpose Of Review: The present review addresses diagnostic methods for crystalline arthritis including synovial fluid analysis, ultrasound, and dual energy CT scan (DECT).

Recent Findings: There are new technologies on the horizon to improve the ease, sensitivity, and specificity of synovial fluid analysis. Raman spectroscopy uses the spectral signature that results from a material's unique energy absorption and scatter for crystal identification. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377265PMC
March 2019
2 Reads

Gout and cardiovascular disease: crystallized confusion.

Curr Opin Rheumatol 2019 Mar;31(2):118-124

Crystal Diseases Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.

Purpose Of Review: Gout is associated with the risk of cardiovascular morbidity and mortality, but the biological relationship between the two remains uncertain. The demonstration of reduction of cardiovascular risk with appropriate gout treatment would argue for a causal role for gout in cardiovascular disease. We reviewed recent studies that address the relationship between gout and cardiovascular disease. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000585DOI Listing
March 2019
2 Reads

The role of febuxostat in gout.

Curr Opin Rheumatol 2019 Mar;31(2):152-158

Department of Rheumatology, Hôpital Lariboisière, APHP.

Purpose Of Review: Concerns about the cardiovascular safety of febuxostat lead to reconsideration of the place of febuxostat in the management of gout.

Recent Findings: The CARES trial is a randomized controlled trial mandated by the FDA to compare the cardiovascular safety of febuxostat and allopurinol in the management of gout. About 6190 patients with gout and major cardiovascular disease, randomly assigned to allopurinol or febuxostat, were prospectively followed up for a median of 32 months. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000573DOI Listing
March 2019
4 Reads

Patient perspectives in gout: a review.

Curr Opin Rheumatol 2019 Mar;31(2):159-166

Medicine Service, VA Medical Center.

Purpose Of Review: Recent studies have produced evidence regarding the patient perspectives in gout including from disease experience to disease outcomes. Therefore, an overview on the topic can help improve our understanding of the patient experience.

Recent Findings: This article explores several aspects of the patient perspective including the impact of gout on a patient's life, patient knowledge and beliefs regarding gout and its treatments, patient-perceived barriers to optimal medication adherence in gout and patient's perception of their gout. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000583DOI Listing
March 2019
5 Reads

Genetic advances in gout: potential applications in clinical practice.

Curr Opin Rheumatol 2019 Mar;31(2):144-151

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland.

Purpose Of Review: Many novel genetic associations in the field of hyperuricaemia and gout have been described recently. This review discusses advances in gout genetics and their potential clinical applications.

Recent Findings: Genome-wide association studies have identified approximately 30 serum urate-associated loci, some of which represent targets for drug development in gout. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000571DOI Listing
March 2019
4 Reads

The immune podocyte.

Curr Opin Rheumatol 2019 Mar;31(2):167-174

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction. It is often debated whether these cells are innocent bystanders or active participants in the pathogenesis of glomerulonephritis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000578DOI Listing
March 2019
3 Reads

Low-dose interleukin-2 therapy for the treatment of systemic lupus erythematosus.

Curr Opin Rheumatol 2019 Mar;31(2):208-212

Department of Rheumatology and Clinical Immunology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany.

Purpose Of Review: To provide an overview behind the concept and recent advances of low-dose interleukin-2 (IL-2) therapy in systemic lupus erythematosus (SLE).

Recent Findings: A disruption of regulatory T cell homeostasis caused by an acquired deficiency of IL-2 is a crucial event in the pathogenesis of SLE. Here, we highlight the key rationales for the clinical translation of low-dose IL-2 therapy in SLE and summarize the main findings from two independent, early phase uncontrolled clinical studies that investigated the immunological and clinical responses to low-dose IL-2 therapy in patients with active SLE. Read More

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http://Insights.ovid.com/crossref?an=00002281-201903000-0001
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http://dx.doi.org/10.1097/BOR.0000000000000575DOI Listing
March 2019
4 Reads

Neutrophils in lupus nephritis.

Curr Opin Rheumatol 2019 Mar;31(2):193-200

Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital & Harvard Medical School, Boston, USA.

Purpose Of Review: Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a subset of granulocytes, called low-density granulocytes (LDG) may contribute to lupus nephritis pathogenesis. Here, we will discuss recent studies implicating neutrophils in the pathogenesis of human SLE nephritis and then examine studies that provide mechanistic insights into how these cells are recruited to the glomerulus following immune complex deposition and how their products may promote lupus nephritis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000577DOI Listing
March 2019
2 Reads

Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations.

Curr Opin Rheumatol 2019 Mar;31(2):175-184

Department of Medicine/Rheumatology and Clinical Immunology.

Purpose Of Review: This review summarizes recent insights and current understanding of the role of postactivated B cells in SLE and related pathogenic and potential therapeutic implications.

Recent Finding: B cells are considered key players in SLE and experience from various B-cell-targeted therapies underlines their clinical relevance. In the last years, new insights have been obtained on B-cell abnormalities within the complex pathophysiology of SLE. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000576DOI Listing
March 2019
3 Reads

Gene-function studies in SLE.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.

Purpose Of Review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

Recent Findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9909
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http://dx.doi.org/10.1097/BOR.0000000000000572DOI Listing
December 2018
16 Reads

Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes.

Curr Opin Rheumatol 2019 Jan;31(1):80-89

The D-BOARD FP7 Consortium.

Purpose Of Review: This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease pathogenesis and progression and define molecular endotypes of osteoarthritis and how these correspond to clinical phenotypes.

Recent Findings: Emerging evidence suggests that osteoarthritis is a heterogeneous and multifaceted disease with multiple causes, molecular endotypes and corresponding clinical phenotypes. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000567DOI Listing
January 2019
14 Reads

Vasculitis and peripheral neuropathy.

Curr Opin Rheumatol 2019 Jan;31(1):40-45

Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Purpose Of Review: Vasculitis of medium-sized and small vessels commonly affects peripheral nerves and can occur in context of a systemic vasculitis with multiorgan involvement or a nonsystemic vasculitis limited to the peripheral nervous system. This review summarizes the clinical and pathological features of systemic and nonsystemic vasculitis of the peripheral nervous system.

Recent Findings: Vasculitis of peripheral nerves is a diffuse process that affects the vasa nervorum along the entire length of affected nerves but appears to cause injury primarily in a zone in the proximal-middle of the nerve that is particularly susceptible to ischemic injury. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000559DOI Listing
January 2019
1 Read

Management of large-vessel vasculitis.

Curr Opin Rheumatol 2019 Jan;31(1):25-31

Department of Internal Medicine, Division of Rheumatology, School of Medicine, Istanbul University - Cerrahpasa, Istanbul, Turkey.

Purpose Of Review: Glucocorticoids are the mainstay of therapy for large-vessel vasculitis, but potential toxicity and frequent relapses led to studies with nonbiologic and biologic glucocorticoid-sparing agents. The aim of this review is to discuss the recent evidence for the management of giant cell arteritis (GCA) and Takayasu arteritis (TAK).

Recent Findings: Tocilizumab proved to be a powerful glucocorticoid-sparing agent for GCA in a randomized placebo-controlled trial, whereas the trials with tocilizumab and abatacept failed to show a significant difference from placebo in relapse-free survival rate in TAK. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000561DOI Listing
January 2019
14 Reads

The role of complement in antineutrophil cytoplasmic antibody-associated vasculitis.

Curr Opin Rheumatol 2019 Jan;31(1):3-8

Department of Pathology.

Purpose Of Review: To provide a comprehensive overview of the current insight into the role of complement activation in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). In addition, the therapeutic options targeting the complement system in AAV are discussed.

Recent Findings: It has become increasingly clear that complement, and more specifically signalling through the C5a receptor, contributes to the immunopathology of AAV. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000557DOI Listing
January 2019
15 Reads

New insights into IgG4-related disease: emerging new CD4+ T-cell subsets.

Curr Opin Rheumatol 2019 Jan;31(1):9-15

Department of Human Immunology, Research Institute for Frontier Medicine.

Purpose Of Review: New insights into IgG4-related disease (IgG4-RD) have recently been obtained. A better understanding of the mechanisms underlying this disease is important for identification of therapeutic targets, which will lead to the development of specific strategies for treatment.

Recent Findings: Infiltration of activated T follicular helper (Tfh) cells is observed in affected tissues of IgG4-RD. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9909
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http://dx.doi.org/10.1097/BOR.0000000000000558DOI Listing
January 2019
14 Reads

Editorial: A review of vasculitis 2019: an introduction.

Curr Opin Rheumatol 2019 Jan;31(1):1-2

Department of Medicine (Rheumatology), New York University School of Medicine.

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http://dx.doi.org/10.1097/BOR.0000000000000565DOI Listing
January 2019
1 Read

Nervous system involvement in Behçet's syndrome.

Curr Opin Rheumatol 2019 Jan;31(1):32-39

Department of Neurology, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey.

Purpose Of Review: Neurological involvement in Behçet's syndrome is defined as 'the occurrence of neurological symptoms and signs in a patient who meets the International Diagnostic Criteria for BS not otherwise explained by any other known systemic or neurological disease or treatment, and in whom objective abnormalities consistent with neuro-Behçet's syndrome (NBS) are detected either on neurological examination, neuroimaging studies (magnetic resonance imaging [MRI]), and/or on cerebrospinal fluid (CSF) examination'. Given that the neurological involvement of Behçet's syndrome carries a poor prognosis, we aimed to describe the differential diagnosis of NBS and highlight the different radiological patterns together with the treatment options.

Recent Findings: Two distinct MRI patterns of spinal cord involvement in Behçet's syndrome according to T2-weighted axial images were described: 'Bagel Sign' pattern: a central lesion with hypointense core and hyperintense rim with or without contrast enhancement; and 'Motor Neuron' pattern: a symmetric involvement of the anterior horn cells. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000562DOI Listing
January 2019
17 Reads

Cardiovascular magnetic resonance in the diagnosis and management of cardiac and vascular involvement in the systemic vasculitides.

Curr Opin Rheumatol 2019 Jan;31(1):16-24

Arthritis Research UK Centre for Epidemiology, Manchester University, Manchester, UK.

Purpose Of Review: Cardiac manifestations in systemic vasculitides, either primary or secondary due to infection, malignancy or autoimmune rheumatic diseases may be life-threatening. Cardiovascular (CVD) magnetic resonance (CMR) has been recently proposed as an ideal noninvasive tool to evaluate systemic vasculitides. In the present article, we present an overview of CMR in the diagnosis and follow-up of cardiac involvement in systemic vasculitides. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000560DOI Listing
January 2019
14 Reads

The ties that bind: skin, gut and spondyloarthritis.

Curr Opin Rheumatol 2019 Jan;31(1):62-69

Unit Molecular Immunology and Inflammation, Inflammation Research Institute VIB-Ghent University.

Purpose Of Review: This article aims to review recent literature linking epithelial barrier inflammation and arthritis in spondyloarthritis (SpA), with a critical view on how they are bound by genetic, immunological and environmental ties.

Recent Findings: The epithelia-joint axis has become an intense area of both basic and clinical SpA research. The penultimate goal is to understand the immunopathologic links between epithelial inflammation and arthritis in SpA. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000569DOI Listing
January 2019
16 Reads

Sex bias in autoimmunity.

Curr Opin Rheumatol 2019 Jan;31(1):53-61

Department of Dermatology.

Purpose Of Review: To give an overview of recently published articles addressing the mechanisms underlying sex bias in autoimmune disease.

Recent Findings: Recent studies investigating the origins of sex bias in autoimmune disease have revealed an extensive and interconnected network of genetic, hormonal, microbial, and environmental influences. Investigation of sex hormones has moved beyond profiling the effects of hormones on activity and prevalence of immune cell types to defining the specific immunity-related genes driving these changes. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9910
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http://dx.doi.org/10.1097/BOR.0000000000000564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296774PMC
January 2019
16 Reads

An update on the nomenclature for cutaneous vasculitis.

Curr Opin Rheumatol 2019 Jan;31(1):46-52

Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Purpose Of Review: Cutaneous vasculitis reflects a spectrum ranging from skin limited to severe systemic forms. To date, there is still no generally acknowledged nomenclature for cutaneous vasculitis. This review aims to summarize the recent advances in the nomenclature of cutaneous vasculitis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000563DOI Listing
January 2019
10 Reads

Osteoarthritis following meniscus and ligament injury: insights from translational studies and animal models.

Curr Opin Rheumatol 2019 Jan;31(1):70-79

Department of Orthopaedic Surgery, Musculoskeletal Research Center.

Purpose Of Review: The interaction between joint injuries and posttraumatic osteoarthritis (PTOA) is generally thought to be mechanical in nature, however, surgical intervention has little effect on the development of PTOA. Little is known about the biological underpinning of how meniscus and anterior cruciate ligament (ACL) tears lead to cartilage degeneration. This review summarizes the latest findings regarding biological factors that influence how the knee responds to meniscus and ligament injuries, how meniscus and/or ACL tears turn the joint in the direction of PTOA and whether patient risk for PTOA after meniscus/ACL injury can be predicted. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9910
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http://dx.doi.org/10.1097/BOR.0000000000000566DOI Listing
January 2019
13 Reads

Lung transplantation in scleroderma: recent advances and lessons.

Curr Opin Rheumatol 2018 Nov;30(6):562-569

Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose Of Review: The purpose of this review is to highlight recent data regarding feasibility and outcomes following lung transplantation for patients with systemic sclerosis related pulmonary disease as well as to emphasize areas of uncertainly in need of further study. We include a description of our centre's approach to lung transplant evaluation and posttransplant management in this complex patient population.

Recent Findings: Historical data have demonstrated that patients with scleroderma have an increased risk of complications following lung transplantation owing to the multisystem nature of disease, particularly concurrent gastrointestinal, cardiac and renal involvement. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000546DOI Listing
November 2018
12 Reads

Antisynthetase syndrome pathogenesis: knowledge and uncertainties.

Curr Opin Rheumatol 2018 Nov;30(6):664-673

Sorbonne Universités, Université Pierre et Marie Curie Université Paris 06, INSERM U1135, CNRS ERL8255, Centre d'Immunologie et des Maladies Infectieuses.

Purpose Of Review: Antisynthetase syndrome (ASyS) is an acquired myopathy characterized by the presence of myositis-specific autoantibodies directed against tRNA-synthetases. ASyS is potentially life threatening due to lung involvement and treatment remains a challenge to date. With symptoms not limited to muscles but also involving lung, skin and joints, ASyS appears specific and has a particular pathogenesis, different from the other inflammatory myopathies. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000555DOI Listing
November 2018
2 Reads

Peculiar clinicopathological features of immune-mediated necrotizing myopathies.

Curr Opin Rheumatol 2018 Nov;30(6):655-663

Sorbonne Universités, AP-HP, Hôpital Pitié Salpêtrière, Département de médecine Interne et Immunologie Clinique, Centre de Référence Maladies Neuro-Musculaires.

Purpose Of Review: In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, and until recently, the definition was based on muscular pathological features.

Recent Findings: It was shown that they are the most severe autoimmune myopathies in term of muscle damages. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000547DOI Listing
November 2018
12 Reads

Gastrointestinal involvement in systemic sclerosis: diagnosis and management.

Curr Opin Rheumatol 2018 Nov;30(6):533-540

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: This review provides important updates in systemic sclerosis (SSc)-related gastrointestinal disease, with a particular focus on the diagnosis and management of dysmotility.

Recent Findings: In the past 2 years, several studies were published that present interesting diagnostic insights into SSc and gastrointestinal dysmotility. Studies focusing on new therapies and the novel application of existing therapies, both in SSc and non-SSc-associated gastrointestinal dysmotility syndromes, demonstrate progress in the management of these challenging complications. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000545DOI Listing
November 2018
1 Read

Recent progress in systemic sclerosis-interstitial lung disease.

Curr Opin Rheumatol 2018 Nov;30(6):570-575

Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Systemic sclerosis is a systemic autoimmune disorder wherein interstitial lung disease (ILD) is the major source or morbidity and mortality. Research into mechanisms of fibrosis and its intersection with autoimmunity, specifically lung fibrosis, has accelerated and been applied to autoimmune disorders such as scleroderma. This review highlights important emerging insights and treatment trials. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9910
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http://dx.doi.org/10.1097/BOR.0000000000000544DOI Listing
November 2018
7 Reads

T cells and cytokines in systemic sclerosis.

Curr Opin Rheumatol 2018 Nov;30(6):594-599

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Purpose Of Review: Dysregulation of both the innate and the adaptive immune systems has been identified in systemic sclerosis (SSc). However, the mechanisms underlying aberrant immune cell function remain poorly understood. T cells represent a predominant cell type in the affected tissues of patients, particularly in the early inflammatory stage of the disease. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000553DOI Listing
November 2018
1 Read

New insights in myositis-specific autoantibodies.

Curr Opin Rheumatol 2018 Nov;30(6):614-622

Unit of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.

Purpose Of Review: The aim of this study was to provide the most recent evidence on clinical utility of myositis-specific autoantibodies (MSAs) in the management of patients with myositis.

Recent Findings: In the last few years, several evidences have emerged on the clinical and pathogenetic role of established and novel MSA. Antisynthetase antibodies represent a reliable biomarker for pulmonary involvement also in patients with connective tissue diseases other than myositis. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9910
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http://dx.doi.org/10.1097/BOR.0000000000000548DOI Listing
November 2018
10 Reads

Innate immunity and Toll-like receptor signaling in the pathogenesis of scleroderma: advances and opportunities for therapy.

Curr Opin Rheumatol 2018 Nov;30(6):600-605

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Purpose Of Review: Systemic sclerosis (SSc) is an autoimmune connective tissue disease in which inflammation and cytokine dysregulation leads to skin fibrosis. Toll-like receptors (TLRs) are conserved pattern recognition receptors, recognizing pathogens danger-associated molecular patterns (DAMPs) that elicit a cascade of proinflammatory signaling. Recently, TLRs have been found to be critically important in SSc pathogenesis, with increased levels of the TLRs and their ligands present in the disease. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000542DOI Listing
November 2018
3 Reads

Dermatomyositis etiopathogenesis: a rebel soldier in the muscle.

Curr Opin Rheumatol 2018 Nov;30(6):623-629

Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda.

Purpose Of Review: The purpose of this article is to review the etiopathogenesis of dermatomyositis, including the predisposing factors, triggers, inflammatory cells, pathways and target antigens associated with dermatomyositis.

Recent Findings: During the last few years, we have made considerable progress in unveiling the etiopathogenesis of dermatomyositis. In the first place, we have defined genes within the major histocompatibility complex locus as the greatest genetic risk factor for the disease. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000540DOI Listing
November 2018
22 Reads

Mortality and survival in systemic sclerosis: a review of recent literature.

Curr Opin Rheumatol 2018 Nov;30(6):588-593

Division of Rheumatology, University of Pennsylvania, Philadelphia, USA.

Purpose Of Review: Systemic sclerosis is a debilitating rheumatic disease with high morbidity and mortality. This review attempts to provide the most recent update on mortality and survival and their determinants in systemic sclerosis (SSc).

Recent Findings: SSc remains an uncommon rheumatic disease with high mortality. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000551DOI Listing
November 2018
13 Reads
4.890 Impact Factor

Muscle disease in scleroderma.

Authors:
Julie J Paik

Curr Opin Rheumatol 2018 Nov;30(6):576-580

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: This review discusses the most updated literature of muscle disease in scleroderma in the past year.

Recent Findings: In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microangiopathy was a common co-feature on muscle biopsies. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000552DOI Listing
November 2018
20 Reads

An update on autoantibodies in scleroderma.

Curr Opin Rheumatol 2018 Nov;30(6):548-553

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: New research continues to provide important insights into the utility of antibody specificities. This review provides an update of recent findings, and the important insights they provide into disease mechanism.

Recent Findings: A growing number of autoantibodies have been discovered in scleroderma patients with unique clinical associations. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000550DOI Listing
November 2018
2 Reads

Recent developments in classification criteria and diagnosis guidelines for idiopathic inflammatory myopathies.

Curr Opin Rheumatol 2018 Nov;30(6):606-613

NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre.

Purpose Of Review: The aim of this review was to summarize key developments in classification and diagnosis of the idiopathic inflammatory myopathies (IIMs).

Recent Findings: The recently published European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for the IIMs provide a comprehensive, accurate and data-driven approach to identification of IIM cases appropriate for inclusion in research studies. Further, recent studies have advanced understanding of clinical manifestations of the IIMs and delineated the role of imaging, particularly magnetic resonance. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170146PMC
November 2018
12 Reads

Calcinosis in scleroderma.

Curr Opin Rheumatol 2018 Nov;30(6):554-561

Stanford University School of Medicine and Palo Alto VA Healthcare System, Division of Immunology and Rheumatology, and Dermatology, Palo Alto, California, USA.

Purpose Of Review: To provide an update on the available literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc).

Recent Findings: We identified observational studies that describe the frequency of calcinosis in SSc and associated clinical features; molecular studies exploring potential pathogenic mechanisms; and case reports and case series describing new diagnostic approaches and treatments.

Summary: Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. Read More

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http://Insights.ovid.com/crossref?an=00002281-900000000-9911
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http://dx.doi.org/10.1097/BOR.0000000000000539DOI Listing
November 2018
28 Reads

Juvenile dermatomyositis: novel treatment approaches and outcomes.

Curr Opin Rheumatol 2018 Nov;30(6):650-654

Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Foundation Trust.

Purpose Of Review: The aim of this article is to provide a summary of the recent therapeutic advances and the latest research on outcome measures for juvenile dermatomyositis (JDM).

Recent Findings: Several new international studies have developed consensus-based guidelines on diagnosis, outcome measures and treatment of JDM to standardize and improve patient care. Myositis-specific antibodies together with muscle biopsy histopathology may help the clinician to predict disease outcome. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000538DOI Listing
November 2018
6 Reads

Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy?

Curr Opin Rheumatol 2018 Nov;30(6):581-587

Centre for Rheumatology and Connective Tissue Diseases, Research Department of Inflammation, Division of Medicine, University College London, London, UK.

Purpose Of Review: The persistence of myofibroblasts is a key feature of fibrosis and in fibrotic diseases including scleroderma. This review evaluates the emerging concepts of the origins and cell populations that contribute to myofibroblasts and the molecular mechanisms that govern phenotypic conversion and that highlight opportunities for new interventional treatments in scleroderma.

Recent Findings: Studies have defined heterogeneity in fibroblast-like cells that can develop into myofibroblast in normal wound healing, scarring and fibrosis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000543DOI Listing
November 2018
15 Reads

Advances in the early diagnosis and therapy of inclusion body myositis.

Authors:
James B Lilleker

Curr Opin Rheumatol 2018 Nov;30(6):644-649

Faculty of Biology Medicine and Health, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester.

Purpose Of Review: To describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM).

Recent Findings: Our understanding of the implications of anti-cytosolic 5'-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance techniques and ultrasound is increasingly being performed and characteristic patterns of muscle involvement may help with diagnosis. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000537DOI Listing
November 2018
17 Reads

The clinico-serological spectrum of overlap myositis.

Curr Opin Rheumatol 2018 Nov;30(6):637-643

Rheumatology and Clinical Immunology Unit, ASST-Spedali Civili of Brescia.

Purpose Of Review: To provide the most recent evidence on the overlap myositis.

Recent Findings: Several new evidences on the overlap myositides have recently emerged. Regarding the classical myositis associated antibodies, several contributions focused on a better definition of the clinical associations and the disease course associated with these autoantibodies. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000536DOI Listing
November 2018
2 Reads

Hematopoietic stem-cell transplantation in systemic sclerosis: an update.

Curr Opin Rheumatol 2018 Nov;30(6):541-547

Department of Rheumatology and Clinical Immunology.

Purpose Of Review: To provide an overview of recently published work on autologous hematopoietic stem-cell transplantation (HSCT) in patients with systemic sclerosis (SSc).

Recent Findings: Superiority of HSCT vs. intravenous cyclophosphamide pulses was demonstrated in the randomized controlled American Scleroderma: Cyclophosphamide or Transplantation (SCOT) Trial (n = 75), supporting the results from earlier studies. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000541DOI Listing
November 2018
16 Reads