1,125,999 results match your criteria Current Opinion in Pediatrics[Journal]


Quality of Bowel Preparation for Colonoscopy in Patients with a History of Abdomino-Pelvic Surgery: Retrospective Cohort Study.

Yonsei Med J 2019 Jan;60(1):73-78

Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. Read More

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January 2019

Characteristics of dietary intake among adult patients in hospitals in a lower middle-income country in Southeast Asia.

Nutr Diet 2018 Dec 16. Epub 2018 Dec 16.

School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology Australia, Kelvin Grove, Queensland, Australia.

Aim: Low-dietary intake is a common problem and cause of malnutrition during hospitalisation. This study aims to determine the current dietary intake and food sources of hospitalised adults in Ho Chi Minh City.

Methods: Participants were adult patients from six general public hospitals in a multi-site survey undertaken in 2016. Read More

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December 2018

A Multi-Model Framework to Estimate Perfusion Parameters Using Contrast-Enhanced Ultrasound Imaging.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Purpose: Contrast-enhanced ultrasound imaging (CEUS) has expanded the diagnostic potential of ultrasound by enabling real-time imaging and quantification of tissue perfusion. Several perfusion models and curve fitting methods have been developed to quantify the temporal behavior of tracer signal and standardize perfusion quantification. While the least-squares approach has traditionally been applied for curve-fitting, it can be inadequate for noisy and complex data. Read More

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December 2018

The Challenge to Search for New Nervous System Disease Biomarker Candidates: the Opportunity to Use the Proteogenomics Approach.

J Mol Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Functional Genomics and Bioinformatics, Oswaldo Cruz Institute, Fundação Oswaldo Cruz (Fiocruz), Manguinhos, Rio de Janeiro, Brazil.

Alzheimer's disease, Parkinson's disease, prion diseases, schizophrenia, and multiple sclerosis are the most common nervous system diseases, affecting millions of people worldwide. The current scientific literature associates these pathological conditions to abnormal expression levels of certain proteins, which in turn improved the knowledge concerning normal and affected brains. However, there is no available cure or preventive therapy for any of these disorders. Read More

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December 2018

Management of Cerebral Microbleeds in Clinical Practice.

Transl Stroke Res 2018 Dec 15. Epub 2018 Dec 15.

Stroke Program, Department of Medicine, University of Alberta, Edmonton, T6G 2G3, Canada.

Cerebral microbleeds (CMBs) are very frequent diagnoses with MRI imaging in the elderly or in patients with cerebral infarction, intracranial hemorrhage (ICH), and dementia. The mechanisms for CMBs are not fully understood but may be secondary to injury to the vascular wall from long-standing hypertension or amyloid deposition in the tissue. The presence of CMB increases the risk for stroke, dementia, and death. Read More

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December 2018

Autonomous self-fertilization in Linum sulcatum, a native annual with a previously unknown mating system.

J Plant Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Biology, University of Minnesota Duluth, 207A Swenson Science Building, Duluth, MN, 55812, USA.

The mating systems of wild plant populations have profound effects on their genetic structure and evolution, yet remain unknown or incompletely described for many species. One such species, the herbaceous native annual Linum sulcatum Riddell (Linaceae), is thought to be self-compatible, but there has been no experimental evidence to date to support this claim. To assess the breeding system of this species, seeds were collected from wild populations and reared in a controlled environment. Read More

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December 2018

Visualization technologies for 5-ALA-based fluorescence-guided surgeries.

J Neurooncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.

Introduction: 5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of malignant gliomas. However, it remains ineffective in guiding the resection of lower-grade, non-enhancing, and deep-seated tumors, mainly because these tumors do not produce detectable fluorescence with conventional visualization technologies, namely, wide-field (WF) surgical microscopy.

Methods: We describe some of the main factors that limit the sensitivity and accuracy of conventional WF surgical microscopy, and then provide a survey of commercial and research prototypes being developed to address these challenges, along with their principles, advantages and disadvantages, as well as the current status of clinical translation for each technology. Read More

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December 2018

Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer.

Breast Cancer Res Treat 2018 Dec 15. Epub 2018 Dec 15.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.

Purpose: CD133/ prominin 1 is a cancer stem cell marker associated with cancer progression and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) remains obscure. The current study aims to assess the prognostic value of CD133 expression in early invasive BC.

Methods: CD133 mRNA was assessed in the METABRIC cohort and at the proteomic level using immunohistochemistry utilising a large well-characterised BC cohort. Read More

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December 2018

Idiopathic Pulmonary Fibrosis for Cardiologists: Differential Diagnosis, Cardiovascular Comorbidities, and Patient Management.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Milan, Italy.

The presence of rare comorbidities in patients with cardiovascular disease (CVD) presents a diagnostic challenge to cardiologists. In evaluating these patients, cardiologists are faced with a unique opportunity to shorten diagnosis times and direct patients towards correct treatment pathways. Idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease (ILD), is an example of a rare disease where patients frequently demonstrate comorbid CVD. Read More

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December 2018

Novel flourescent spiroborate esters: potential therapeutic agents in in vitro cancer models.

Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.

The current treatment system in cancer therapy, which includes chemotherapy/radiotherapy is expensive and often deleterious to surrounding healthy tissue. Presently, several medicinal plants and their constituents are in use to manage the development and progression of these diseases.They have been found effective, safe, and less expensive. Read More

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December 2018

College Students' Perception of Current and Projected 30-Year Cardiovascular Disease Risk Using Cluster Analysis with Internal Validation.

Authors:
Dieu-My T Tran

J Community Health 2018 Dec 15. Epub 2018 Dec 15.

School of Nursing, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy, Box 453018, Las Vegas, NV, 89154-3018, USA.

Cardiovascular risk factors in young adults at a national level are less than ideal specifically for hypercholesterolemia, hypertension, and diabetes. Explore college students' perception of their 30-year cardiovascular disease (CVD) risk using cluster analysis technique with internal validation. This is a descriptive and cross-sectional study. Read More

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December 2018

Consensus Statement of the Italian Society of Colorectal Surgery (SICCR): management and treatment of complete rectal prolapse.

Tech Coloproctol 2018 Dec 15. Epub 2018 Dec 15.

Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy.

Rectal prolapse, rectal procidentia, "complete" prolapse or "third-degree" prolapse is the full-thickness prolapse of the rectal wall through the anal canal and has a significant impact on quality of life. The incidence of rectal prolapse has been estimated to be approximately 2.5 per 100,000 inhabitants with a clear predominance among elderly women. Read More

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December 2018

Breast cancer survivors' perspectives on a home-based physical activity intervention utilizing wearable technology.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, Alberta, Canada.

Purpose: To gain breast cancer survivors' perspectives on participation in a home-based physical activity intervention and the factors that contributed to their acceptance and adherence to physical activity.

Methods: Semi-structured interviews were conducted with six women who had participated in a 12-week, home-based physical activity intervention using Polar A360® activity trackers. Additionally, 22 participants from the physical activity interventions provided scaled responses to barriers of physical activity on weeks 3, 6, 9, and 12. Read More

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December 2018

Playing Super Mario increases oculomotor inhibition and frontal eye field grey matter in older adults.

Exp Brain Res 2018 Dec 15. Epub 2018 Dec 15.

Centre de Recherche en Neuropsychologie et Cogntion, University of Montreal, Pavillon Marie-Victorin 90, Avenue Vincent d'Indy, Montreal, QC, H2V 2S9, Canada.

Aging is associated with cognitive decline and decreased capacity to inhibit distracting information. Video game training holds promise to increase inhibitory mechanisms in older adults. In the current study, we tested the impact of 3D-platform video game training on performance in an antisaccade task and on related changes in grey matter within the frontal eye fields (FEFs) of older adults. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018

Current Status and Challenges of Endoscopic Treatments for Duodenal Tumors.

Digestion 2018 Dec 14;99(1):21-26. Epub 2018 Dec 14.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo,

Background: Superficial tumors of the duodenum, other than ampullary tumors, have been traditionally considered rare. However, reports of this kind of tumor have increased in recent times, and the demand for minimally invasive treatments have also increasing.

Summary: Adenomas and intramucosal carcinomas are target lesions for treatment. Read More

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December 2018

Ulipristal Acetate before Hysteroscopic and Laparoscopic Surgery for Uterine Myomas: Help or Hindrance?

Gynecol Obstet Invest 2018 Dec 14:1-13. Epub 2018 Dec 14.

Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Background/aims: Ulipristal acetate ([UPA], Esmya®) is an orally active selective progesterone-receptor modulator that has been approved as preoperative treatment for uterine myomas. This systematic review aims to summarize the available data on surgical outcomes of patients undergoing myomectomy by hysteroscopy or by laparoscopy after preoperative treatment with UPA.

Methods: this review was performed following PRISMA guidelines and was registered in PROSPERO (CRD42018092201). Read More

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December 2018

The Relationship between Weight Status and Depressive Symptoms in a Population Sample with Obesity: The Mediating Role of Appearance Evaluation.

Obes Facts 2018 Dec 14;11(6):514-523. Epub 2018 Dec 14.

Integrated Research and Treatment Center (IFB) AdiposityDiseases, University Hospital Leipzig, Leipzig, Germany.

Objectives: Identifying the underlying pathways between obesity and depression and which individuals with obesity are at risk for developing depressive symptoms is important for improving prevention and treatment efforts. The current study investigated appearance evaluation as a potential mediator of the relationship between obesity and depression.

Methods: A total of 1,000 participants with a self-reported BMI greater than 30 kg/m2 were interviewed about their experiences with an elevated body weight and completed measures on appearance evaluation and depression. Read More

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December 2018

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2018 Dec 14;99(1):66-71. Epub 2018 Dec 14.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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December 2018

Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Digestion 2018 Dec 14;99(1):86-94. Epub 2018 Dec 14.

Sino United Health Clinic, Gopher Medical Center, Rui Jing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: To elucidate the current management of ulcerative colitis (UC)-associated cancer, a questionnaire-based survey was conducted to gather current opinions on colitis-associated cancer in different East Asian countries.

Methods: The questionnaire, based on physicians, contains 9 questions focused on UC management and cancer surveillance. In addition, the questionnaire based on neoplastic cases, which contains 17 questions, was collected and analyzed. Read More

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December 2018

Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet.

Digestion 2018 Dec 14:1-7. Epub 2018 Dec 14.

Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila,

Background And Aim: Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients with CD, before and after a GFD.

Methods: One hundred eighty-five coeliac adult patients were enrolled in the study. Read More

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December 2018

Topical vancomycin for neurosurgery wound prophylaxis: an interim report of a randomized clinical trial on drug safety in a diverse neurosurgical population.

Authors:

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

OBJECTIVEPostoperative surgical site infections (SSIs) in neurosurgical patients carry a significant risk of increased morbidity and mortality. With SSIs accounting for approximately 20% of nosocomial infections and costing approximately $1.6 billion USD annually, there is a need for additional prophylaxis to improve current standards of care. Read More

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December 2018

Screening and surgery for foramen magnum stenosis in children with achondroplasia: a large, national database analysis.

Authors:

J Neurosurg Pediatr 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVEThe goal of this study was to determine the rates of screening and surgery for foramen magnum stenosis in children with achondroplasia in a large, privately insured healthcare network.METHODSRates of screening and surgery for foramen magnum stenosis in children with achondroplasia were determined using de-identified insurance claims data from a large, privately insured healthcare network of over 58 million beneficiaries across the United States between 2001 and 2014. Cases of achondroplasia and screening and surgery claims were identified using a combination of International Classification of Diseases diagnosis codes and Current Procedural Terminology codes. Read More

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December 2018

Use of supplemental oxygen in emergency patients: a systematic review and recommendations for military clinical practice.

J R Army Med Corps 2018 Dec 15. Epub 2018 Dec 15.

Emergency Department, University Hospitals Plymouth NHS Trust, Plymouth, UK.

Introduction: Supplemental oxygen is a key element of emergency treatment algorithms. However, in the operational environment, oxygen supply poses a challenge. The lack of high-quality evidence alongside emerging technologies provides the opportunity to challenge current guidelines. Read More

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December 2018

Cohort effects of tobacco control policy: evidence to support a tobacco-free norm through smoke-free policy.

Tob Control 2018 Dec 15. Epub 2018 Dec 15.

Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea.

Background: The prevalence of cigarette smoking among South Korean adolescents has decreased markedly over the past decade, which may indicate a norm shift between generations of adolescents. The present study aims to identify the effect of banning smoking in public places and increasing cigarette prices on current adolescent smoking, and to determine whether these policies additionally resulted in cohort effects.

Methods: Repeated cross-sectional survey data, nationally representative of South Korean adolescents, were used. Read More

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December 2018

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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December 2018

SMART-CPT for veterans with comorbid post-traumatic stress disorder and history of traumatic brain injury: a randomised controlled trial.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA.

Objective: To better concurrently address emotional and neuropsychological symptoms common in veterans with comorbid post-traumatic stress disorder (PTSD) and history of traumatic brain injury (TBI), we integrated components of compensatory cognitive training from the Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) programme into cognitive processing therapy (CPT) for PTSD to create a hybrid treatment, SMART-CPT (CogSMART+CPT). This study compared the efficacy of standard CPT with SMART-CPT for treatment of veterans with comorbid PTSD and history of TBI reporting cognitive symptoms.

Methods: One hundred veterans with PTSD, a history of mild to moderate TBI and current cognitive complaints were randomised and received individually delivered CPT or SMART-CPT for 12 weeks. Read More

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December 2018

Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

Objective: Many studies examining stroke outcomes focus on more severe strokes or have short follow-up periods, so the long-term outcomes post-minor ischaemic stroke are unclear.

Methods: We recruited participants from inpatient and outpatient services with a lacunar or minor cortical ischaemic stroke (National Institutes of Health Stroke Scale score <8) and assessed current and premorbid cognitive functioning (Addenbrooke's Cognitive Examination-Revised (ACE-R), National Adult Reading Test (NART)), physical functioning (Timed Get Up and Go (TUG), 9-Hole Peg Test (9HPT)), dependency (modified Rankin Scale (mRS)), depression (Beck's Depression Inventory) in-person and remotely (Stroke Impact Scale).

Results: We followed up 224/264 participants at 3 years (mean age at index stroke=67, 126 (56%) men, 25 non-contactable, 15 declined): 66/151 (44%) had cognitive impairment, mean ACE-R 88 (SD 9, range 54-100/100), 61/156 (39%) had depression and 26/223 (12%) were dependent (mRS=3-5). Read More

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December 2018

Exchanges of nitrogen and phosphorus across the sediment-water interface influenced by the external suspended particulate matter and the residual matter after dredging.

Environ Pollut 2018 Dec 5;246:207-216. Epub 2018 Dec 5.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, PR China; Jiangsu Provincial Key Laboratory of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, PR China.

Dredging is frequently implemented for the reduction of internal nitrogen (N) and phosphorus (P) loadings and the control of eutrophication. Residuals during dredging activities and external pollution loadings after dredging both commonly contribute to influence the effectiveness of dredging and have been widely discussed. In the current study, the exchanges of N and P across the sediment-water interface (SWI) to these two factors were compared in a six-month field incubation experiment. Read More

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December 2018

Public stigma of obsessive compulsive disorder and schizophrenic disorder: Is there really any difference?

Psychiatry Res 2018 Dec 10;271:559-564. Epub 2018 Dec 10.

Department of Psychology, Faculty of Arts, Dokuz Eylül University, Buca, İzmir, Turkey.

A substantial delay for help-seeking is a serious problem for people with obsessive-compulsive disorder (OCD), a heterogeneous and debilitating mental health condition. Stigma is a major barrier to treatment seeking and further cause social and occupational impairment. Lack of comprehensive research led us to examine the public's stigmatizing attitudes towards checking, contamination, sexuality, aggression, and religion-related OCD symptoms, compared to schizophrenia. Read More

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December 2018

Simultaneous detection of ATP metabolites in human plasma and urine based on palladium nanoparticle and poly(bromocresol green) composite sensor.

Biosens Bioelectron 2018 Dec 8;126:758-766. Epub 2018 Dec 8.

Department of Chemistry and Institute of BioPhysio Sensor Technology (IBST), Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes. The linear calibration curves were obtained in the concentration range of 0. Read More

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December 2018

Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 8;1105:15-25. Epub 2018 Dec 8.

Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:

A simple, sensitive and selective high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated for simultaneous determination and pharmacokinetic study of 15 active compounds (Saikosaponin A, Baicalin, Wogonin, Glycyrrhizic acid, Glycyrrhetinic acid, Albiflorin, Paeoniflorin, Liquiritin, Isoliquiritin, Liquiritigenin, Isoliquiritigenin, Cinnamic acid, Gallic acid, Wogonoside and Oroxylin A) in rat plasma. After a feasible protein precipitation using methanol for sample preparation, chromatographic separation was carried out with a Halo® C column (2.1 × 100 mm, 2. Read More

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December 2018

"It's about bloody time": Perceptions of people who use drugs regarding drug law reform.

Int J Drug Policy 2018 Dec 13;64:40-46. Epub 2018 Dec 13.

Drug Policy Modelling Program, University of New South Wales, 22-32 King Street, Randwick NSW 2031, Australia.

Background: In Australia and elsewhere, the impacts of drug prohibition have sparked a critical dialogue about the state of current drug laws. While a range of 'experts' have offered their opinion and participation in these deliberations, the voices of the affected community have largely been excluded. This study aimed to gather the opinions and preferences of people who use drugs about the current or alternative models of drug laws, in addition to how they think drug laws could be changed Author Conflict of Interest Declaration. Read More

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December 2018

Tough decisions in medical specialty camps: Relationships between camp dosage, outcomes, and camper attendance.

Soc Sci Med 2018 Dec 10;221:49-57. Epub 2018 Dec 10.

Department of Parks, Recreation and Tourism, Clemson University, Clemson, USA.

Rationale: Medical specialty camps play a significant role in the lives of the youth they serve. These camps have been found to improve self-determination in campers, to develop camper skills in managing a disability or coping with a diagnosis, and to provide campers with respite/escape from the challenges associated with their disability or diagnosis. Youth attending medical specialty camps are often funded through full or partial scholarships, mitigating a significant constraint to their participation. Read More

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December 2018

Recent advances in metalloporphyrins for environmental and energy applications.

Chemosphere 2018 Dec 4;219:617-635. Epub 2018 Dec 4.

School of Environmental Science and Engineering, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China; Hubei Provincial Engineering Laboratory of Solid Waste Treatment, Disposal and Recycling, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China. Electronic address:

Porphyrin-based chemistry has reached an unprecedented period of rapid development after decades of study. Due to attractive multifunctional properties, porphyrins and their analogues have emerged as multifunctional organometals for environmental and energy purposes. In particular, pioneer works have been conducted to explore their application in pollution abatement, energy conversion and storage and molecule recognition. Read More

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December 2018

Auspicious or suspicious - Does religiosity really promote elder well-being? Examining the belief-as-benefit effect among older Japanese.

Arch Gerontol Geriatr 2018 Dec 7;81:129-135. Epub 2018 Dec 7.

Charles Sturt University, Bathurst, NSW, Australia. Electronic address:

Recent findings suggest that the belief-as-benefit effect (BABE) - the positive association between religiosity and health/well-being - is a spurious correlation voided by personality traits. The current paper investigates the cross-sectional relationships among personality, religiosity and psychological well-being in an older adult sample randomly-selected from Tokyo, Japan. Correlation and Hierarchical Regression Modelling (HRM)-with a two one-sided test (TOST) of equivalence-is utilized. Read More

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December 2018

Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells.

Biomaterials 2018 Dec 10;193:47-57. Epub 2018 Dec 10.

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, 04103, Germany. Electronic address:

Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase mediated crosslinking has been observed in advanced tumor stages. Many current reports suggest that the local mechanical properties of single fibrillar components dominantly regulate cancer cell behavior. Read More

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December 2018

Five financial incentives to revive the Gulf of Mexico dead zone and Mississippi basin soils.

J Environ Manage 2018 Dec 13;233:30-38. Epub 2018 Dec 13.

The Nature Conservancy, Arlington, VA, USA.

A central challenge in the Mississippi River Basin is how to continue to support profitable agricultural production, provide water supply, flood control, transportation, and other benefits, while reducing the current burden of environmental degradation. Several practices have been shown to reduce nutrient runoff and water pollution, and improve soil fertility, while often yielding profits for farmers. Yet many of these beneficial practices remain underutilized. Read More

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December 2018

Using virtual reality for forensic examinations of injuries.

Forensic Sci Int 2018 Nov 16;295:30-35. Epub 2018 Nov 16.

Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland; 3D Zentrum Zürich, Winterthurerstrasse 190/52, CH-8057 Zürich, Switzerland. Electronic address:

The ability to accurately determine injury dimensions is an essential property of forensic documentation. The current standard for injury documentation is photography using a scale to approximate the injury dimensions in the image. The technical qualities of the photograph, such as orthogonality, depth of the field and sharpness of the desired area, are vital to obtaining a correct measurement. Read More

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November 2018

Predictive validity of hypodensities on non-contrast computed tomography for hematoma growth in intracerebral hemorrhage: a meta-analysis.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Objective: Intracerebral hemorrhage (ICH) is a kind of stroke which leads to high mortality. Hematoma growth (HG) happens in about one third of all ICH patients and independently related to poor outcome. Previous studies have shown that an indicator on non-contrast computed tomography (NCCT), called hypodensities, can predict HG in ICH patients. Read More

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December 2018

Lipidomic analysis reveals the efficiency of Eclipta prostrata on diet-induced nonalcoholic fatty liver disease in rats.

J Pharm Biomed Anal 2018 Nov 30;165:224-232. Epub 2018 Nov 30.

Department of Therapeutic Chemistry, National Research Centre, Cairo, Egypt.

Non-alcoholic fatty liver disease is a leading cause of chronic liver disease in western countries. The current study aimed to detect and evaluate lipidomic biomarkers for early detection of NAFLD as well as the potential efficiency of methanolic extract of Eclipta prostrata (E. prostrata) on disease management. Read More

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November 2018

Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.

Int J Pharm 2018 Dec 13. Epub 2018 Dec 13.

Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P.R. China. Electronic address:

Controlled drug-delivery systems have potential as substitutes for traditional medication systems due to the advantages in safety, efficacy, and patient compliance that these long-acting dosage forms provide. In this context, the present study focus on the development of self-implanted hyaluronicacid (HA) tiny needles that encapsulate ivermectin (IVM)-poly (lactic-co-glycolic acid) (PLGA) microparticles for controlled transdermal IVM release to treat parasitic diseases. The fabricated tiny needles involved matching portable applicator have potentially able for self-administration by patients without intense pain or complexity of current controlled-release devices. Read More

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December 2018

Proteomics turns functional.

J Proteomics 2018 Dec 13. Epub 2018 Dec 13.

Department of Science and High Technology, Center of Bioinformatics, University of Insubria, Busto Arsizio, Italy. Electronic address:

Proteomics is acquiring a pivotal role in the comprehensive understanding of human biology. Biochemical processes involved in complex diseases, such as neurodegenerative diseases, diabetes and cancer, can be identified by combining proteomics analysis and bioinformatics tools. In the last ten years, the main output of differential proteomics investigations evolved from long lists of proteins to the generation of new hypotheses and their functional verification. Read More

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December 2018

Typology of cannabis use among adults: A latent class approach to risk and protective factors.

Addict Behav 2018 Dec 10;92:6-13. Epub 2018 Dec 10.

University of Houston, Department of Psychology, Houston, TX, United States; The University of Texas MD Anderson Cancer Center, Department of Behavioral Science, Houston, TX, United States. Electronic address:

Background: Cannabis is among the most widely used substances worldwide. The United States has seen an increase in the number of adult daily cannabis users and in the number of adults diagnosed with cannabis use disorder. However, little work has examined patterns of use or unique subgroups of adult cannabis users, which may be useful in developing targeted treatment interventions for problematic cannabis users. Read More

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December 2018

Iron Deficiency in Heart Failure: An Overview.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Iron deficiency is an extremely common co-morbidity in patients with heart failure, affecting up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and physical well-being and reduced quality of life. Cutoff values have been identified for diagnosing iron deficiency in heart failure with reduced ejection fraction as serum ferritin, <100 μg/l, or ferritin, 100 to 300 μg/l, with transferrin saturation of <20%. Read More

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December 2018

NMDA receptors of blood lymphocytes anticipate cognitive performance variations in healthy volunteers.

Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.

Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Working memory (WM) system, temporarily stores information and uses this information for complex cognitive tasks. WM connects memory, emotional feelings and perception. Evidence compelling that N-methyl d-aspartate receptor (NMDAR) expression relatively affect WM performance in animal models. Read More

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December 2018

Effects of parity and litter size on cortisol measures in commercially housed sows and their offspring.

Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.

Behavior & Welfare Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus, Utrecht University, Utrecht, The Netherlands.

Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. Read More

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December 2018

Effects of high-soy diet on S100 gene expression in liver and intestine of rainbow trout (Oncorhynchus mykiss).

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Aquaculture Research Institute, University of Idaho, 3059F National Fish Hatchery Rd, Hagerman, ID, 83332, USA.

The current study examines expression of S100 genes, a group of calcium-sensing proteins poorly characterized in fishes. In mammals, these proteins are known to play roles beyond calcium-signaling, including mediation of inflammatory processes. Some S100 proteins also serve as biomarkers for a variety of autoinflammatory conditions. Read More

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December 2018

Imprinted genes influencing the quality of maternal care.

Front Neuroendocrinol 2018 Dec 13. Epub 2018 Dec 13.

Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, UK, CF10 3AX, UK. Electronic address:

In mammals successful rearing imposes a cost on later reproductive fitness specifically on the mother creating the potential for parental conflict. Loss of function of three imprinted genes in the dam result in deficits in maternal care suggesting that, like maternal nutrients, maternal care is a resource over which the parental genomes are in conflict. However, the induction of maternal care is a complex and highly regulated process. Read More

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December 2018

Endoplasmic reticulum stress triggered by Soyasapogenol B promotes apoptosis and autophagy in colorectal cancer.

Life Sci 2018 Dec 13. Epub 2018 Dec 13.

The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Aim: Colorectal cancer (CRC) is a common human malignancy which accounts for 600,000 deaths annually at the global level. Soyasapogenol B (Soy B), an ingredient of soybean, has been found to exert anti-proliferative activities in vitro in human breast cancer cells. The current study aimed to evaluate the efficacy of Soy B in suppressing CRC. Read More

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December 2018
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