2,200 results match your criteria Current Opinion in Ophthalmology[Journal]


Small gauge vitrectomy: operative techniques.

Curr Opin Ophthalmol 2019 May;30(3):159-164

Illinois Retina Associates, Rush University Medical Center, Chicago, IL USA.

Purpose Of Review: This article reviews operative techniques and risks associated with microincision vitrectomy surgery.

Recent Findings: All three microincision vitrectomy surgery platforms (23, 25, and 27 gauge) are associated with both advantages and disadvantages, combined with similarly low rates of hypotony, endophthalmitis, corneal astigmatism, and postoperative inflammation.

Summary: Hybrid-gauge vitrectomy, utilizing larger gauge MIVS cannulas, preserves surgeon access to benefits of both larger and smaller gauge MIVS platforms without compromising safety, efficacy, or efficiency. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000568DOI Listing

Editorial: Translational research.

Curr Opin Ophthalmol 2019 May;30(3):165

MidAtlantic Retina, The Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvanial.

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http://dx.doi.org/10.1097/ICU.0000000000000565DOI Listing

Advances in dry eye disease treatment.

Curr Opin Ophthalmol 2019 May;30(3):166-178

Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.

Purpose Of Review: The prevalence and burden of dry eye disease continues to grow at a rapid pace, creating an increased need for new therapies. In a sector once limited to only a handful of treatments, clinicians now have multiple options available for patients who fail traditional therapies. This review summarizes the various treatment options available to clinicians treating complex dry eye disease patients. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000569DOI Listing

Precision medicine to prevent glaucoma-related blindness.

Curr Opin Ophthalmol 2019 May;30(3):187-198

Department of Ophthalmology and Visual Sciences, WK Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Purpose Of Review: Approximately 10% of patients become blind despite using evidence-based guidelines developed from clinical trials and epidemiology studies. Our purpose is to review opportunities to decrease glaucoma-related blindness using the emerging principles of precision medicine.

Recent Findings: The current review focuses on three topics: first, candidate biomarkers for angle-based surgeries, second, head-mounted display (HMD) technology for vision and testing, and third, glaucoma risk alleles discovered by genome-wide association studies. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000564DOI Listing

Endoresection utilizing pars plana vitrectomy for benign and malignant intraocular tumors.

Curr Opin Ophthalmol 2019 May;30(3):151-158

Tennessee Retina, Nashville, TN, USA.

Purpose Of Review: Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors.

Recent Findings: Endoresection has been utilized in some form for the last three decades, but recent advances in vitreoretinal surgery have improved the technique. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000561DOI Listing
May 2019
1 Read

Introduction to hypersonic vitrectomy.

Curr Opin Ophthalmol 2019 May;30(3):133-137

Bausch & Lomb, Rochester, New York, USA.

Purpose Of Review: To review the development of hypersonic vitrectomy and present the first case series in the United States.

Recent Findings: From 27 September 2017 to 4 December 2017, 64 patients underwent hypersonic vitrectomy with 20 patients having conventional 23-ga vitrectomy for comparison. The preoperative diagnoses ranged from vitreous opacities to rhegmatogenous retinal detachments. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000563DOI Listing

Biologics for the treatment of noninfectious uveitis: current concepts and emerging therapeutics.

Authors:
Akshay S Thomas

Curr Opin Ophthalmol 2019 May;30(3):138-150

Tennessee Retina, Nashville, USA.

Purpose Of Review: There is mounting evidence supporting the use of biologic therapeutics for the management of noninfectious uveitis (NIU). This review highlights: biologics with documented efficacy in NIU; agents with ongoing evaluation for efficacy in uveitis; and therapeutics for which investigation for efficacy in NIU is warranted.

Recent Findings: The tumor necrosis factor-alpha (TNF-α) inhibitor adalimumab has recently gained approval by the Food and Drug Administration for the treatment of noninfectious intermediate, posterior, and panuveitis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000562DOI Listing
May 2019
12 Reads

Small choroidal melanoma: detection with multimodal imaging and management with plaque radiotherapy or AU-011 nanoparticle therapy.

Curr Opin Ophthalmol 2019 May;30(3):206-214

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose Of Review: To explore risk factors for choroidal nevus transformation into melanoma using multimodal imaging and review current treatment options.

Recent Findings: A recently published longitudinal study of 3806 choroidal nevi, imaged with optical coherence tomography (OCT), ultrasonography, and standard wavelength autofluorescence, revealed transformation into melanoma in 5.8% at 5 years and 13. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000560DOI Listing

Therapeutic advances in juvenile idiopathic arthritis - associated uveitis.

Curr Opin Ophthalmol 2019 May;30(3):179-186

Department of Ophthalmology, IHU FORESIGHT, Pitié-Salpêtrière Hospital, APHP, Sorbonne-University.

Purpose Of Review: The aim of this review is to highlight recent changes in the treatment of juvenile idiopathic arthritis (JIA) - associated uveitis in the era of biologics.

Recent Findings: Early introduction of steroid-sparing therapies is paramount for appropriate management. Biologic therapies have improved the therapeutic management of JIA-uveitis and adalimumab is currently approved for pediatric-onset noninfectious chronic anterior uveitis with an inadequate response to topical steroids and methotrexate. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000559DOI Listing

Retinal neuroprotection: current strategies and future directions.

Curr Opin Ophthalmol 2019 May;30(3):199-205

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

Purpose Of Review: Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders. Currently, there are no commercially available treatments to prevent photoreceptor cell loss and preserve vision, and there is a critical unmet need for neuroprotective modalities to improve photoreceptor survival in a multitude of retinal disorders. This review summarizes the literature published on this topic in the last 18 months. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000558DOI Listing
May 2019
4 Reads

Editorial introduction.

Authors:

Curr Opin Ophthalmol 2019 03;30(2)

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http://dx.doi.org/10.1097/ICU.0000000000000556DOI Listing
March 2019
7 Reads

Current opinion in ophthalmology: novel glaucoma devices in the pipeline.

Curr Opin Ophthalmol 2019 Mar;30(2):117-124

University of Colorado School of Medicine, Aurora, Colorado, USA.

Purpose Of Review: Adherence to chronic use of topical intraocular pressure (IOP) lowering medications is a fundamental barrier to successful, long-term control in patients suffering from glaucoma. This has fueled innovation to create new vehicles for drug administration, new drug formulations with enhanced bioavailability, and minimally invasive glaucoma surgeries (MIGS) with improved risk-benefit profiles to enhance sustained IOP control. The present article is an overview of novel devices in the pipeline. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000555DOI Listing
March 2019
3 Reads

Optical coherence tomography angiography in glaucoma.

Curr Opin Ophthalmol 2019 Mar;30(2):110-116

Department of Ophthalmology, University of Washington, Seattle, Washington, USA.

Purpose Of Review: Optical coherence tomography angiography (OCTA) studies have demonstrated reduced microcirculation in the superficial optic nerve, peripapillary retina, and the macula of glaucoma patients. The scope of this review is to outline recent studies using OCTA in glaucoma and highlight how OCTA may help improve diagnosis and follow-up in glaucoma patients.

Recent Findings: OCTA studies have provided evidence of vascular changes in the optic nerve head, peripapillary, and macula region in glaucoma in comparison to glaucoma suspects and normal eyes. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000554DOI Listing
March 2019
1 Read

New developments in tube shunt surgery.

Curr Opin Ophthalmol 2019 Mar;30(2):125-131

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Purpose Of Review: This article reviews recent studies related to tube shunt surgery.

Recent Findings: Medical claims data and surveys of glaucoma surgeons demonstrate that tube shunts are being selected with increasing frequency as an alternative to trabeculectomy. A 5-year pooled analysis of the Ahmed Baerveldt comparison study and Ahmed versus Baerveldt study found a higher rate of surgical success with the Baerveldt glaucoma implant compared with the Ahmed glaucoma valve, but Baerveldt implantation carried a higher risk of hypotony. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000549DOI Listing
March 2019
3 Reads

Myopic optic disc changes and its role in glaucoma.

Curr Opin Ophthalmol 2019 Mar;30(2):89-96

Singapore Eye Research Institute.

Purpose Of Review: Optic nerve head (ONH) changes such as tilt and torsion are associated with the progression of myopia, and may in turn predispose toward glaucoma. At the same time, these ONH deformations also make the structural assessment for glaucoma difficult. Here, we review the mechanisms and changes to the myopic optic disc, and the advances in structural imaging to better evaluate the ONH in myopia. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000548DOI Listing
March 2019
1 Read
2.500 Impact Factor

Artificial intelligence in glaucoma.

Curr Opin Ophthalmol 2019 Mar;30(2):97-103

Wilmer Eye Institute.

Purpose Of Review: The use of computers has become increasingly relevant to medical decision-making, and artificial intelligence methods have recently demonstrated significant advances in medicine. We therefore provide an overview of current artificial intelligence methods and their applications, to help the practicing ophthalmologist understand their potential impact on glaucoma care.

Recent Findings: Techniques used in artificial intelligence can successfully analyze and categorize data from visual fields, optic nerve structure [e. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000552DOI Listing
March 2019
13 Reads

Relationship of lifestyle, exercise, and nutrition with glaucoma.

Curr Opin Ophthalmol 2019 Mar;30(2):82-88

Glaucoma Center of San Francisco, San Francisco, California, USA.

Purpose Of Review: Although reducing the intraocular pressure (IOP) through medications, laser or surgery remains the primary means of glaucoma treatment, there is increasing evidence during the last decade that environmentally modifiable factors may help to prevent glaucoma or its progression through different mechanisms that may or may not involve lowering IOP. Additionally, patients are increasingly interested in maintaining a healthy lifestyle and taking an active role in the management of their disease. Therefore, the aim of this review is to summarize the current evidence regarding environmentally modifiable factors such as lifestyle, exercise, and nutrition in the pathogenesis of glaucoma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000553DOI Listing
March 2019
1 Read

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
12 Reads

Influence of new treatment modalities on adherence in glaucoma.

Curr Opin Ophthalmol 2019 Mar;30(2):104-109

Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.

Purpose Of Review: It is well known that glaucoma patients are not adherent to their therapeutic regimens. The issue of nonadherence is multifactorial and includes inadequate communication between doctors and patients, resulting in significant costs associated with enhanced disease progression. Therapeutic regimens are risk factors which often influences adherence rates. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000551DOI Listing
March 2019
2 Reads

Early postoperative intraocular pressure elevation following cataract surgery.

Curr Opin Ophthalmol 2019 Jan;30(1):56-62

Private Practice, Gdańsk, Poland.

Purpose Of Review: The aim of this review was to assess the risk factors and course of postoperative intraocular pressure (IOP) increase in order to determine the optimal the treatment.

Recent Findings: Early postoperative IOP elevation following cataract surgery is a frequent adverse event, and might represent 88% early postoperative complications. The risk factors for IOP elevation following phacoemulsification cataract surgery include residual viscoelastic material, resident performed surgery, glaucoma, pseudoexfoliation syndrome, axial length over 25 mm, tamsulosin intake, topical steroid application in steroid responders. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000545DOI Listing
January 2019
14 Reads

The evolution of toxic anterior segment syndrome.

Curr Opin Ophthalmol 2019 Jan;30(1):50-55

Department of Ophthalmology, Rabin Medical Center, Petach Tikva.

Purpose Of Review: Toxic anterior segment syndrome (TASS) is a surgical complication resulting from a noninfectious inflammatory reaction to substances used during intraocular ophthalmic surgery. Continuous reporting of new information concerning risk factors and possible causes is critical for preventing this condition.

Recent Findings: The diagnosis of TASS is clinical and its main features are well known. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000540DOI Listing
January 2019
17 Reads

Cataract grading systems: a review of past and present.

Curr Opin Ophthalmol 2019 Jan;30(1):13-18

Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, San Diego, California, USA.

Purpose Of Review: To provide a comprehensive summary of past cataract grading systems, how they have shaped current grading systems, and the developing technologies that are being used to assess and grade cataracts.

Recent Findings: This summary of cataract grading systems examines the development and limitations that existed in past grading systems and how they have shaped the grading systems of present time. The Lens Opacities Classification System III (LOCS III) system is currently used both clinically and for research purposes. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000542DOI Listing
January 2019
4 Reads

Preoperative evaluation for cataract surgery.

Curr Opin Ophthalmol 2019 Jan;30(1):3-8

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: To provide a consolidated update regarding preoperative evaluation for cataract surgery.

Recent Findings: Visual acuity alone is a poor gauge of cataract disability. Modalities such as wave front aberrometry, lens densitometry, and light-scatter assessments can quantify optical aspects of cataract and may prove clinically useful in surgical evaluation. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000535DOI Listing
January 2019
2 Reads
2.500 Impact Factor

Editorial: Improvements in cataract surgery planning, technique, and outcomes.

Curr Opin Ophthalmol 2019 01;30(1):1-2

Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1097/ICU.0000000000000543DOI Listing
January 2019
9 Reads

Advances in capsulorhexis.

Curr Opin Ophthalmol 2019 Jan;30(1):19-24

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

Purpose Of Review: Continuous curvilinear manual capsulorhexis is currently the standard of cataract surgery. In the past several years, new technologies have been developed to improve the consistency and safety of capsulorhexis creation. This article reviews the most recent technologies in capsulotomy formation and their advantages and disadvantages. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000539DOI Listing
January 2019
11 Reads

Biometry in cataract surgery: a review of the current literature.

Curr Opin Ophthalmol 2019 Jan;30(1):9-12

Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri, USA.

Purpose Of Review: To review the literature in 2017 and 2018 pertaining to biometry for cataract surgery and report pertinent findings.

Recent Findings: New devices using swept-source ocular coherence tomography can measure axial length in dense cataracts more frequently than common biometers. Computer-assisted registration may be superior to intraoperative aberrometry for toric intraocular lens (IOL) placement. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000536DOI Listing
January 2019
23 Reads

The role of perioperative nonsteroidal anti-inflammatory drugs use in cataract surgery.

Curr Opin Ophthalmol 2019 Jan;30(1):44-49

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.

Purpose Of Review: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used and studied by cataract surgeons for varied benefits in the perioperative period, but optimal medication formulae and dosing have yet to be established. In this article, we perform a literature review of articles published between 1 January 2016 and 30 June 2018 concerning perioperative NSAID use for patients undergoing cataract surgery.

Recent Findings: Literature review revealed five areas of recent study including preoperative NSAID use for iatrogenic inflammation, intraoperative NSAID use for pupillary mydriasis, postoperative NSAID use for prevention of cystoid macular edema (CME), for prevention of pain/inflammation, and for improvement in patient quality of life. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000541DOI Listing
January 2019
1 Read

Cataract surgery and lens implantation.

Authors:
Siyuan Li Ying Jie

Curr Opin Ophthalmol 2019 Jan;30(1):39-43

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose Of Review: This review aims to introduce recent updates in cataract surgery and lens implantation.

Recent Findings: Compared to phacoemulsification, femtosecond laser-assisted cataract surgery (FLACS) may offer benefit for cataract patients with other complicated ocular diseases, such as corneal disease and vitreous abnormalities. Meanwhile, several types of novel intraocular lenses (IOLs) have been introduced to the market, and each of them has particular features in improving patients' visual acuity. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000547DOI Listing
January 2019
13 Reads

Different methods of chopping in cataract surgery.

Authors:
Soosan Jacob

Curr Opin Ophthalmol 2019 Jan;30(1):25-38

Dr Agarwal's Eye Hospital and Eye Research Centre, Chennai, India.

Purpose Of Review: To review the different methods of chopping in cataract surgery.

Recent Findings: Chop techniques are of advantage in reducing the amount of phaco energy, endothelial damage as well as zonular stress to the eye. Various methods have been described including the classical horizontal and vertical chops as well as newer chop techniques for all grades of cataract. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000538DOI Listing
January 2019
1 Read

Nutritional effect on age-related cataract formation and progression.

Curr Opin Ophthalmol 2019 Jan;30(1):63-69

Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.

Purpose Of Review: To provide a comprehensive summary of the latest evidence-based data on nutrients linked to the pathogenesis of cataract formation and progression.

Recent Findings: This summary of peer-reviewed publications emphasizes the ongoing effort to modulate the cataractogenous process through nutrition, and points at an only weak evidence for the contribution of a specific nutrient to this process. Although observational studies successfully demonstrated a positive correlation between specific nutrients intake and age-related cataract, such evidence was usually lacking in following interventional studies. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000537DOI Listing
January 2019
33 Reads

Multimodal imaging of diabetic retinopathy.

Curr Opin Ophthalmol 2018 Nov;29(6):566-575

Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose Of Review: Diabetic retinopathy is the most common microvascular complication of diabetes mellitus and a leading cause of blindness throughout the world. Ocular imaging continues to play a vital role in the diagnosis, management and monitoring of diabetic retinopathy. Major technological advancements in imaging over the past decade have improved our understanding and knowledge of diabetic retinopathy and therefore a multimodal approach to imaging has become the standard of care. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000524DOI Listing
November 2018
11 Reads
2.500 Impact Factor

Ocular manifestations of cytomegalovirus in immunocompetent hosts.

Curr Opin Ophthalmol 2018 Nov;29(6):535-542

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, USA.

Purpose Of Review: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts.

Recent Findings: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000521DOI Listing
November 2018
6 Reads

Myelin oligodendrocyte glycoprotein-IgG-associated optic neuritis.

Curr Opin Ophthalmol 2018 Nov;29(6):508-513

Neuro-Ophthalmology Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Myelin oligodendrocyte glycoprotein (MOG)-IgG-associated optic neuritis has been established as a new entity of optic neuropathy. We will review recent advances in pathophysiology, diagnosis, and clinical manifestations of MOG-IgG-associated optic neuritis to better understand its distinctive characteristics.

Recent Findings: MOG is expressed on the surface of myelin sheaths and oligodendrocytes. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000520DOI Listing
November 2018
2 Reads

Ocular myasthenia gravis: an update on diagnosis and treatment.

Curr Opin Ophthalmol 2018 Nov;29(6):477-484

Department of Neurology, St Elizabeth's Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: Myasthenia gravis is an autoimmune disease that commonly affects the palpebral and extraocular muscles. Ocular myasthenia gravis (OMG) is a variant of the disease that is confined to the ocular muscles but frequently becomes generalized over time. The diagnosis of OMG is often challenging but both clinical and laboratory findings are helpful in confirming the clinical suspicion. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000526DOI Listing
November 2018
1 Read

Drug-induced uveitis.

Curr Opin Ophthalmol 2018 Nov;29(6):588-603

The Department of Ophthalmology, California Pacific Medical Center, San Francisco.

Purpose Of Review: Nearly one-half of all uveitis cases seen at tertiary referral centers have no identifiable cause. Many systemic, paraocular, intraocular, topical medications, and even vaccines can induce intraocular inflammation, scleritis, and rarely orbititis and are often overlooked as causes of uveitis. This review was undertaken to elucidate the strength of association of these medications with uveitis and to make clinicians aware of these associations, especially among newer medications. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000530DOI Listing
November 2018
26 Reads

Ocular involvement in atopic disease: a review.

Curr Opin Ophthalmol 2018 Nov;29(6):576-581

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami.

Purpose Of Review: To provide a review of the potential sight-threatening sequelae associated with ocular involvement of atopic disease and to discuss the management of this chronic condition.

Recent Findings: There has been a recognition that atopic keratoconjunctivitis (AKC) is a chronic, inflammatory and potentially blinding disease. Recent efforts have focused on steroid sparing, systemic T cell and calcineurin inhibitor medications for the treatment of severe disease. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000532DOI Listing
November 2018
10 Reads

Ocular cicatricial pemphigoid.

Curr Opin Ophthalmol 2018 Nov;29(6):543-551

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California, USA.

Purpose Of Review: This review offers recommendations for monitoring disease status in ocular cicatricial pemphigoid as well therapeutic options including local and systemic therapies.

Recent Findings: A negative biopsy on direct immunofluorescence does not preclude a diagnosis of OCP. If a patient's cicatrization is active and/or progressive, systemic immunosuppression should be commenced. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000517DOI Listing
November 2018
5 Reads

Neuro-ophthalmic complications of IgG4-related disease.

Curr Opin Ophthalmol 2018 Nov;29(6):485-494

Department of Neuro-Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA.

Purpose Of Review: IgG4-related disease (IgG4-RD) is increasingly recognized as a fibroinflammatory disease with a plethora of organ-specific manifestations but a particular predilection for head and neck tissues, including the nervous system. This review discusses general features and organ-specific presentations of IgG4-RD as well as treatment considerations, particularly emphasizing features of neuro-ophthalmic interest.

Recent Findings: IgG4-RD is emerging as a common cause of several fibroinflammatory disorders in the head and neck that were previously considered idiopathic, such as sclerosing orbital pseudotumor, orbital myositis, hypophysitis, and hypertrophic pachymeningitis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000523DOI Listing
November 2018
19 Reads

An update of idiopathic intracranial hypertension.

Curr Opin Ophthalmol 2018 Nov;29(6):495-502

Department of Neuro-ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

Purpose Of Review: We aim to provide a comprehensive and updated review on idiopathic intracranial hypertension (IIH), including the most current studies and treatment options. Special focus will be put on recent theories about the pathophysiology, and on newer prospective studies on treatment modalities.

Recent Findings: The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) provided evidence supporting acetazolamide as a well tolerated first-line therapy in IIH patients with mild vision loss. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000518DOI Listing
November 2018
22 Reads

Opportunistic ocular infections in the setting of HIV.

Curr Opin Ophthalmol 2018 Nov;29(6):558-565

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.

Purpose Of Review: The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients.

Recent Findings: Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000531DOI Listing
November 2018
21 Reads

Neuroretinitis: a review.

Curr Opin Ophthalmol 2018 Nov;29(6):514-519

Department of Ophthalmology, Edward Harkness Eye Institute, Columbia University, New York, New York, USA.

Purpose Of Review: Neuroretinitis is an inflammatory disorder of the eye presenting with optic disc edema and the delayed development of a macular star secondary to optic nerve swelling toward the macular structures. Neuroretinitis can be divided into idiopathic, infectious (including neuroretinitis associated with cat scratch disease) and recurrent.

Recent Findings: The clinical presentation of neuroretinitis includes impaired visual acuity, dyschromatopsia, relative afferent pupillary defects and visual field abnormalities - particularly cecocentral and central scotomas. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000527DOI Listing
November 2018
8 Reads

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies.

Curr Opin Ophthalmol 2018 Nov;29(6):552-557

Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin, USA.

Purpose Of Review: The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations. It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000525DOI Listing
November 2018
21 Reads

Update on giant cell arteritis.

Curr Opin Ophthalmol 2018 Nov;29(6):520-527

Save Sight Institute, University of Sydney.

Purpose Of Review: Giant cell arteritis (GCA) is a challenging condition to manage because of the potential for acute irreversible vision loss and corticosteroid-related morbidity. Recent developments offer the potential to improve both the assessment and treatment of patients.

Recent Findings: Vascular imaging is increasingly being used in the diagnostic algorithm for GCA. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000528DOI Listing
November 2018
18 Reads

Thyroid eye disease: what is new to know?

Curr Opin Ophthalmol 2018 Nov;29(6):528-534

Neuro-Ophthalmology Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The pathophysiology of thyroid eye disease (TED) is still not fully understood. However, recently described risk factors and molecular findings have brought new insights into the mechanisms of TED and could lead to the emerging use of more targeted therapies. This article aims to review the clinical findings of TED, and the most recent advances in our understanding of the risk factors and therapeutic options for TED. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000529DOI Listing
November 2018
34 Reads

Ocular manifestations of bartonellosis.

Curr Opin Ophthalmol 2018 Nov;29(6):582-587

Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: To review the systemic and ocular complications of Bartonella spp. infections specifically cat scratch disease, encompassing epidemiology, laboratory diagnostics, ophthalmic imagining, and treatment.

Recent Findings: Recent studies have shown that ocular manifestations occur in approximately 4. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000522DOI Listing
November 2018
20 Reads

Imaging in neuro-ophthalmology in the context of value-based care.

Curr Opin Ophthalmol 2018 Nov;29(6):503-507

Massachusetts Eye and Ear Infirmary, Boston, USA.

Purpose Of Review: Neuro-ophthalmic imaging is an invaluable tool for clinical decision-making and has evolved rapidly. At the same time, both imaging utilization and healthcare costs have skyrocketed, and concern for imaging overuse has become a salient topic. This article gives an overview of the current state of neuro-ophthalmic imaging from a value-based medicine lens and discusses recent neuro-ophthalmic advancements in OCT with these considerations in mind. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000519DOI Listing
November 2018
18 Reads

Pediatric optic neuritis.

Curr Opin Ophthalmol 2018 Sep;29(5):419-422

Department of Pediatric Ophthalmology and Adult Strabismus, Wills Eye Hospital, Philadephia, PA.

Purpose Of Review: Pediatric optic neuritis may be challenging to diagnose and treat. Significant clinical investigation of optic neuritis occurring in adults guides current clinical practices. Differences in presentation and prognosis exist for pediatric patients with optic neuritis when compared with adults including the risk of developing multiple sclerosis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000509DOI Listing
September 2018
16 Reads

Current management of childhood ptosis.

Authors:
Daniel T Weaver

Curr Opin Ophthalmol 2018 Sep;29(5):395-400

Billings Clinic, Billings, Montana, USA.

Purpose Of Review: Blepharoptosis is a common problem encountered in the pediatric ophthalmology clinic. The presentation is obvious to both parents and referring physicians and often prompts urgent consultation. The current classification and management of childhood ptosis will be reviewed. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000508DOI Listing
September 2018
1 Read

New classification system for pediatric glaucoma: implications for clinical care and a research registry.

Curr Opin Ophthalmol 2018 Sep;29(5):385-394

Sidney Kimmel Medical College at Thomas Jefferson University.

Purpose Of Review: The Childhood Glaucoma Research Network (CGRN) has created a new classification system for childhood glaucoma that has become the first International Consensus Classification. The purpose of this review is to present this classification system and share its use to date.

Recent Findings: The diagnoses of the classification system include glaucoma and glaucoma suspect. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000516DOI Listing
September 2018
44 Reads

Nonsurgical treatment of diplopia.

Curr Opin Ophthalmol 2018 Sep;29(5):381-384

Family Eye Care of the Carolinas, Aberdeen, North Carolina, USA.

Purpose Of Review: As the population ages, the number of patients presenting to ophthalmologists with complaints of double vision is increasing.

Recent Findings: Diplopia is known to occur for optical, neuroophthalmological, strabismological and even iatrogenic reasons following various ophthalmic surgical procedures. The mainstays of the nonsurgical treatment of diplopia including no treatment, partial or total occlusion, press-on or ground in prisms and vergence exercises (to increase fusional vergence amplitudes) have been utilized for some time. Read More

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http://Insights.ovid.com/crossref?an=00055735-900000000-9924
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http://dx.doi.org/10.1097/ICU.0000000000000513DOI Listing
September 2018
5 Reads