5 results match your criteria Current Opinion in Internal Medicine[Journal]

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Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the CLCN5 gene.

Intern Med 2018 Dec 10;57(24):3603-3610. Epub 2018 Aug 10.

Department of Nephrology, Osaka University Graduate School of Medicine, Japan.

We present a case of Dent disease caused by a novel intronic mutation, 1348-1G>A, of the chloride voltage-gated channel 5 (CLCN5) gene. Cultured proximal tubule cells obtained from the patient showed impaired acidification of the endosome and/or lysosome, indicating that the 1348-1G>A mutation was indeed the cause of Dent disease. Although the prevalence of osteomalacia in Dent disease is low in Japan, several factors-including poor medication adherence-caused severe osteomalacia in the current case. Read More

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http://dx.doi.org/10.2169/internalmedicine.1272-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355425PMC
December 2018
8 Reads

Medical Attitudes Survey for Female Dystrophinopathy Carriers in Japan.

Intern Med 2018 Aug 9;57(16):2325-2332. Epub 2018 Mar 9.

Translational Medical Center, National Center of Neurology and Psychiatry, Japan.

Objective This study attempted to clarify the current status of female dystrophinopathy carriers, including the numbers of patients, the status of genetic screening, the status of counseling, physicians' understanding, and barriers to registration. Methods We sent out questionnaires to 402 physicians registered in the Remudy dystrophinopathy registry. The total number of responses received was 130 (response rate: 32%). Read More

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http://dx.doi.org/10.2169/internalmedicine.0163-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148176PMC
August 2018
9 Reads

Patient Perspectives on Combination Therapy of a Once-weekly Oral Medication Plus Daily Medication for Lifestyle-related Chronic Diseases.

Intern Med 2017 17;56(6):615-620. Epub 2017 Mar 17.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.

Objective The current study investigated whether or not patients taking multiple daily oral medications for lifestyle-related chronic diseases would have positive perspectives on changing one of their medications to a once-weekly one. Methods A total of 1,071 Japanese outpatients participated in the current study. We performed a questionnaire-based survey and compared the current satisfaction with the ongoing daily oral treatment (current daily-only treatment) and an expected satisfaction with an imaginary oral treatment changing one of their daily oral medications to a once-weekly oral medication (imaginary daily-and-weekly treatment). Read More

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http://dx.doi.org/10.2169/internalmedicine.56.7583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410468PMC
May 2017
19 Reads

Recruitment of patients for a clinical trial: factors on the physician side and reasons on the patient side.

Intern Med 2006 15;45(8):511-4. Epub 2006 May 15.

Clinical Practice Evaluation and Research Center, St. Luke's Life Science Institute, St. Luke's International Hospital, Tokyo.

Objectives: To examine the factors related to actual patient recruiters among the physicians who initially agreed to collaborate in a randomized control trial.

Methods: We conducted a questionnaire survey of 679 physicians (512 actual recruiter and 167 non-recruiters) who had initially agreed to recruit patients for a clinical trial to determine factors to predict who would actually do so.

Results: Response rates among recruiters and non-recruiters were 87. Read More

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September 2006
12 Reads

Awareness of the harmful effects of smoking and views on smoking cessation intervention among Japanese medical students.

Authors:
M Kawakami

Intern Med 2000 Sep;39(9):720-6

Department of Internal Medicine, Tokyo Metropolitan Ohtsuka General Hospital.

Objective: To clarify attitudes toward smoking, and views on smoking intervention among medical students, as well as to teach them the harmful effects of smoking.

Subjects And Methods: We carried out an anonymous questionnaire among 2nd and 5th year Japanese medical students and 1,137 of them responded.

Results: Smoking prevalence was 25. Read More

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September 2000
11 Reads
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