1,821 results match your criteria Current Opinion in Gastroenterology[Journal]


Positioning biologics and new therapies in the management of inflammatory bowel disease.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

IBD Centre, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.

Purpose Of Review: Since the advent of anti-tumour necrosis factor agents, knowledge of their optimal use and their pitfalls has grown exponentially. However, the range of therapeutic agents available to clinicians and patients is expanding, creating challenging decisions about which drugs to use at any given time point. The present review aims to provide a framework within which positioning decisions can be made in the context of limited comparative effectiveness data. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000546DOI Listing

Diagnosis and treatment of dermatologic diseases in inflammatory bowel disease.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose Of Review: Dermatologic manifestations in patients with inflammatory bowel disease (IBD) are increasingly recognized as related disorders, secondary to specific therapies used to treat IBD, or complications of IBD itself. These dermatologic manifestations can be difficult to manage.

Recent Findings: We summarize three categories of dermatologic manifestations in this review: extraintestinal cutaneous disorders, paradoxical manifestations to biologic therapies, and other drug-induced cutaneous manifestations. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000538DOI Listing
April 2019
1 Read

Pediatric inflammatory bowel disease: continuous lessons for adult inflammatory bowel disease.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

Division of Pediatric Gastroentology, Department of Pediatrics, Atlanta, Georgia, USA.

Purpose Of Review: Prospective and inception inflammatory bowel disease (IBD) cohorts offer excellent opportunities to develop risk stratification strategies, use relevant tissue to explore the biology of IBD progression, and study the natural history of IBD in the era of biological therapy. Adult IBD care can learn important lessons from recent pediatric IBD studies.

Recent Findings: A recent multicenter inception cohort of pediatric IBD patients examining genetic, serologic, and microbiome data at diagnosis has been able to create a model for prediction of disease complications, describe compositional changes in gut microbiota associated with disease severity, identify markers of intestinal fibrosis, and confirm how important early life environmental exposures affect disease severity and phenotype. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000548DOI Listing

The cyclical hit model: how paligenosis might establish the mutational landscape in Barrett's esophagus and esophageal adenocarcinoma.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology, Department of Internal Medicine.

Purpose Of Review: In this review, we explore a paligenosis-based model to explain Barrett's esophagus development and progression: 'the cyclical hit model.'

Recent Findings: Genomic analyses have highlighted the high mutational burden of esophageal adenocarcinoma, Barrett's esophagus, and even normal esophageal epithelium. Somatic mutations in key genes including TP53 occur early in the neoplastic progression sequence of Barrett's esophagus, whereas chromosomal amplification resulting in oncogene activation occurs as a critical late event. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000540DOI Listing

Inflammatory bowel disease during pregnancy: management of a disease flare or remission.

Authors:
Anita Afzali

Curr Opin Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Purpose Of Review: Roughly half of the nearly 1.6 million people with inflammatory bowel disease (IBD) are women of reproductive age. Caring for women with IBD who are also pregnant can be challenging, particularly if with a disease flare or in remission, as there are special considerations needed. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000541DOI Listing
April 2019
1 Read

The role of the transition clinic from pediatric to adult inflammatory bowel disease care.

Curr Opin Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: The transition of patients from pediatric to adult centered care represents not only the means to transfer medical care to a group of providers who specialize in adult care but also is part of the process of the transfer of healthcare responsibility from the family to a patient. The intent of this review is to provide a summary of some of the important studies published in the past 2 years that advance this knowledge.

Recent Findings: Progress has been made in the recognition of the process of transition, including developing tools to assess transition readiness, improving routes of communication along with patient education. Read More

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http://Insights.ovid.com/crossref?an=00001574-900000000-9920
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http://dx.doi.org/10.1097/MOG.0000000000000535DOI Listing
April 2019
2 Reads

The globalization of inflammatory bowel disease: the incidence and prevalence of inflammatory bowel disease in Brazil.

Curr Opin Gastroenterol 2019 Apr 9. Epub 2019 Apr 9.

Catholic University of Paraná (PUCPR), Curitiba, Brazil.

Purpose Of Review: Epidemiological studies of inflammatory bowel disease (IBD) in newly industrialized countries are limited, due to a lack of medical surveillance systems and reliable and unified registries and databases. In Brazil, reliable data on the incidence and prevalence of Crohn's disease and ulcerative colitis is scarce. The objective of the present review is to describe in detail the available data on the incidence and prevalence of Crohn's disease and ulcerative colitis in Brazil. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000534DOI Listing
April 2019
1 Read

Therapeutic drug monitoring in inflammatory bowel disease: for every patient and every drug?

Curr Opin Gastroenterol 2019 Apr 9. Epub 2019 Apr 9.

Division of Gastroenterology, Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The current review provides an updated overview on the role of therapeutic drug monitoring (TDM) of biological therapies in inflammatory bowel disease (IBD). We examine the data behind TDM for the antitumor necrosis factor agents, vedolizumab and ustekinumab, in patients with IBD. In addition, we discuss reactive vs. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000536DOI Listing
April 2019
1 Read

The ABC's of re-do ileoanal pouches, what every gastroenterologist should know.

Curr Opin Gastroenterol 2019 Apr 9. Epub 2019 Apr 9.

The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Purpose Of Review: To describe the development of re-do pouch surgery, what it entails, its indications and role in the management of patients with inflammatory bowel disease.

Recent Findings: Re-do pouch surgery has very good outcomes and excellent patient satisfaction when performed on carefully selected patients in specialized centers.

Summary: The ileal pouch anal anastomosis (IPAA) procedure, which was developed 40 years ago, is a mainstay in the reconstruction of patients who undergo a proctoclectomy for ulcerative colitis and familial adenomatous polyposis (FAP). Read More

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http://dx.doi.org/10.1097/MOG.0000000000000537DOI Listing
April 2019
3 Reads

Editorial: Delving deeper: every day small bowel diseases to difficult to treat entities.

Authors:
Reena Sidhu

Curr Opin Gastroenterol 2019 May;35(3):197-198

Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1097/MOG.0000000000000521DOI Listing
May 2019
1 Read

Palliative care and end-stage liver disease: a critical review of current knowledge.

Curr Opin Gastroenterol 2019 May;35(3):155-160

Division of Gastroenterology and Hepatology, Loma Linda University Health, Loma Linda, California, USA.

Purpose Of Review: End-stage liver disease (ESLD) is associated with high symptom burden, poor quality of life, and significant healthcare costs. Palliative care, which is not synonymous with hospice or end-of-life care, is a multidisciplinary model of care that focuses on patient-centered goals with the intent of improving quality of life and reducing suffering. This review will summarize current literature supporting the benefits of early integration of palliative care in patients in this population. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000530DOI Listing
May 2019
1 Read

Updates on the pathophysiology and therapeutic targets for hepatic encephalopathy.

Curr Opin Gastroenterol 2019 May;35(3):145-154

Division of Hepatology, Baylor University Medical Center, Dallas, USA.

Purpose Of Review: Hepatic encephalopathy is one of the most debilitating clinical manifestations of cirrhosis and associated with increased morbidity and mortality. Treatment modalities available include the nonabsorbable disaccharides (lactulose) and the nonabsorbable antibiotics (rifaximin).

Recent Findings: Newer therapeutic targets under evaluation include ammonia scavengers (ornithine phenylacetate) and modulation of gut microbiota (fecal microbiota transplantation). Read More

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http://dx.doi.org/10.1097/MOG.0000000000000527DOI Listing
May 2019
4 Reads
4.289 Impact Factor

Chronic diarrhoea in adults: what not to miss.

Curr Opin Gastroenterol 2019 May;35(3):206-212

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust.

Purpose Of Review: Chronic diarrhoea remains a diagnostic challenge, with numerous causes and few effective symptomatic treatments. This review focuses on new methods for diagnosis of common disorders and alerts readers to rarer causes through a systematic approach to the underlying mechanisms.

Recent Findings: New strategies are emerging to stratify the need for endoscopic investigation. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000516DOI Listing
May 2019
2 Reads

Editorial: Advances in Hepatology: 2019.

Authors:
Don C Rockey

Curr Opin Gastroenterol 2019 May;35(3):135-136

Department of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000529DOI Listing
May 2019
1 Read

Fibrosis reversal after hepatitis C virus elimination.

Authors:
Don C Rockey

Curr Opin Gastroenterol 2019 May;35(3):137-144

Department of Internal Medicine, The Medical University of South Carolina, Charleston, USA.

Purpose Of Review: Hepatitis C virus (HCV) infection has been the leading cause of cirrhosis in the United States now for the last several decades. With the introduction of highly effective direct acting antiviral (DAA) drugs, cure rates are now almost 100%. With this explosion of effective therapy, it is possible that many patients with HCV may have reversion in fibrosis. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000524DOI Listing
May 2019
1 Read

Tools for causality assessment in drug-induced liver disease.

Curr Opin Gastroenterol 2019 May;35(3):183-190

Department of Medicine, Medical University South Carolina, Charleston, USA.

Purpose Of Review: There are three liver-specific causality assessment tools currently available to guide clinical diagnosis of Drug-Induced Liver Injury (DILI): Roussel-Uclaf Causality Assessment Method (RUCAM), Digestive-Disease-Week Japan 2004 scale (DDW-J), and Clinical Diagnostic Scale (CDS). The purpose of this review is to assess these tools and discuss how to improve the causality assessment process as a whole.

Recent Findings: Existing DILI-specific causality assessment tools are surprisingly similar and exhibit only minor differences in point allocation. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452904PMC

Small bowel strictures.

Curr Opin Gastroenterol 2019 May;35(3):235-242

AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, RPA Medical Centre, Camperdown, Sydney, New South Wales, Australia.

Purpose Of Review: Strictures of the small bowel are an underdiagnosed entity with significant morbidity because of obstruction and risk of perforation and penetrating disease.

Recent Findings: Recent advances in imaging, enteroscopy, and therapeutic advances particularly in Crohn's disease have enabled gastroenterologists to target and individualize management of small bowel strictures, preventing untimely surgery and complications.

Summary: All patients with obstructive symptoms, suspected small bowel disease, and negative panendoscopy should be evaluated for small intestinal strictures with cross-sectional imaging and considered for capsule endoscopy. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000531DOI Listing
May 2019
6 Reads

Small bowel ulcers: when is it not inflammatory bowel disease ?

Curr Opin Gastroenterol 2019 May;35(3):213-222

Klinik für Innere Medizin, Bethesda Krankenhaus Bergedorf, Akademisches Lehrkrankenhaus der Universität Hamburg, Hamburg, Germany.

Purpose Of Review: Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnosis of small bowel ulcers. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000522DOI Listing
May 2019
10 Reads

Delving deeper: every day small bowel diseases to difficult to treat entities.

Authors:
Reena Sidhu

Curr Opin Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1097/MOG.0000000000000521DOI Listing
February 2019

Management of small bowel polyps: from small to big.

Curr Opin Gastroenterol 2019 May;35(3):250-256

Gastroenterology Unit, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, France.

Purpose Of Review: Benign small bowel polyps or mass are clinically poorly distinguishable from malignant small bowel masses, and the diagnostic conditions are almost the same. The important point for clinicians is first to take advantage of the different available diagnostic tools to optimize the diagnostic algorithm of a small bowel polyp or mass. Next, according to the clinical situation, associated disease or sporadic situation, the difficulty is to adapt the treatment decision to the patient situation. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000518DOI Listing

The role of small bowel endoscopy for Crohn's disease.

Curr Opin Gastroenterol 2019 May;35(3):223-234

Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.

Purpose Of Review: The review discusses the roles of small bowel capsule endoscopy and deep enteroscopy in patients with Crohn's disease. It highlights recent advances in the field and identifies areas where evidence is lacking.

Recent Findings: Small bowel capsule endoscopy has an important role in the follow-up of patients with Crohn's disease after escalation of therapy and in the postoperative assessment period following surgical resection. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000519DOI Listing
May 2019
1 Read

Obeticholic acid in primary biliary cholangitis: where we stand.

Curr Opin Gastroenterol 2019 May;35(3):191-196

Liver Care Network, Swedish Medical Center, Seattle, Washington, USA.

Purpose Of Review: This review will summarize the use of obeticholic acid (OCA) in treatment of primary biliary cholangitis (PBC). It seeks to discuss the mechanism of action, evidence for use, appropriate clinical use, and common adverse effects of OCA.

Recent Findings: PBC is a chronic, progressive cholestatic liver disease that is a chronic progressive that may lead to end-stage liver disease and need for liver transplantation. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000525DOI Listing
May 2019
1 Read

Controversies in anticoagulation therapy in patients with cirrhosis.

Curr Opin Gastroenterol 2019 May;35(3):161-167

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose Of Review: This article aims to review the latest literature on prophylactic and therapeutic anticoagulation and the safety profile of anticoagulants in patients with cirrhosis.

Recent Findings: The understanding of hematological hemostasis is cirrhotic patients has changed drastically in recent years. Although in the past, cirrhotic patients were often considered to be 'auto-anticoagulated' and at higher risk of bleeding, recent studies have demonstrated that there may be a rebalance in procoagulation and anticoagulation factors in patients with cirrhosis. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000523DOI Listing
May 2019
1 Read

Current treatment options for nonalcoholic fatty liver disease.

Curr Opin Gastroenterol 2019 May;35(3):168-176

Section of Gastroenterology, Ralph H Johnson, VAMC.

Purpose Of Review: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States and is strongly associated to the metabolic syndrome. In this review, we will discuss the evidence behind the current recommendations on lifestyle modifications and available treatment options for NAFLD.

Recent Findings: The unrelenting rise in obesity and diabetes epidemic has led to a large healthcare burden from NAFLD and it is projected to continue to grow over the next two decades. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000528DOI Listing
May 2019
4 Reads
4.289 Impact Factor

Population-based screening of hepatitis C virus in the United States.

Curr Opin Gastroenterol 2019 May;35(3):177-182

Department of Medicine, Medical University of South Carolina, Charleston, USA.

Purpose Of Review: This review summarized the recent evidence on the performance of population-based hepatitis C virus (HCV) screening, published and indexed to PubMed, in the Unite States during the 2-year window from 1 January 2017 to 31 December 2018.

Recent Findings: A majority of the selected articles in this review focused on the birth cohort 1945-1965 because of the HCV screening recommendations released after August 2012. However, the articles for the high-risk population applied to all ages because the recommendations for this specific population have remained largely unchanged since 1998. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450713PMC
May 2019
6 Reads

The overlap of irritable bowel syndrome and noncoeliac gluten sensitivity.

Curr Opin Gastroenterol 2019 May;35(3):199-205

Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospital NHS Foundation Trust.

Purpose Of Review: There has been significant interest in gluten over the last decade, with an increase in interest of gluten-related disorders outside coeliac disease. Particularly, there has been a focus on the role of gluten in noncoeliac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS). There is significant overlap between both of these conditions, with the aim of this review to explore their complex relationship. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000517DOI Listing

Demystifying autoimmune small bowel enteropathy.

Curr Opin Gastroenterol 2019 May;35(3):243-249

Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Purpose Of Review: We reviewed the current 'state of the art' on autoimmune enteropathy and small-bowel mucosal atrophy, with the aim of supporting clinicians in a frequently challenging diagnosis through different therapeutic options and prognosis.

Recent Findings: The diagnosis of small-bowel diseases has radically changed over the last 10 years. The possibility to 'easily' obtain bioptic samples from the jejunum and ileum by means of the enteroscopic techniques (particularly, device-assisted enteroscopy) and the novel cross-sectional imaging studies have opened the window to new insights on intestinal disorders. Read More

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http://Insights.ovid.com/crossref?an=00001574-900000000-9922
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http://dx.doi.org/10.1097/MOG.0000000000000515DOI Listing
May 2019
6 Reads

Genetics of polycystic liver diseases.

Curr Opin Gastroenterol 2019 Mar;35(2):65-72

Department of Gastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

Purpose Of Review: This review provides an outline of the most recent insights and significant discoveries regarding the genetic mechanisms involved in polycystic liver disease.

Recent Findings: Polycystic liver disease includes a heterogeneous group of genetic disorders characterized by multiple hepatic cysts. Isolated liver cysts are caused by mutations in Protein Kinase C Substrate 80K-H (PRKCSH), SEC63, and LDL Receptor Related Protein 5 (LRP5), whereas Polycystic Kidney Disease (PKD)1, PKD2, and PKHD1 mutations cause kidney cysts often accompanied by liver cysts. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000514DOI Listing
March 2019
4 Reads

Monitoring long-term parenteral nutrition.

Curr Opin Gastroenterol 2019 Mar;35(2):119-125

Salford Royal Hospital, Salford, England, UK.

Purpose Of Review: This review discusses the monitoring aimed at achieving good long-term outcomes in people dependent on home parenteral nutrition (HPN).

Recent Findings: There have been recent studies highlighting the importance of treating low bone mineral density in HPN-dependent patients, methods of screening for liver disease, assessment of quality of life (QoL) and the need for early assessment for intestinal transplantation and growth factor therapy.

Summary: High-quality HPN services require expert multidisciplinary teams with a focus on strict aseptic catheter care protocols alongside regular monitoring and management of clinical, laboratory and patient-related factors. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000504DOI Listing
March 2019
23 Reads

Editorial: Genetics of cholangiopathies.

Curr Opin Gastroenterol 2019 Mar;35(2):63-64

Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Assistance Publique-Hôpitaux de Paris, Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis (CRMR, MIVB-H), Paris, France.

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http://Insights.ovid.com/crossref?an=00001574-201903000-0000
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http://dx.doi.org/10.1097/MOG.0000000000000510DOI Listing
March 2019
9 Reads

Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.

Curr Opin Gastroenterol 2019 Mar;35(2):82-87

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Purpose Of Review: Gallstone disease is one of the most frequent diseases in gastroenterology and treatment by endoscopy and surgery causes high costs in our health-care systems. Family and twin studies have demonstrated that gallstones are, in part, genetically determined. Here we review all recent genome-wide and phenome-wide studies of gallstones in humans and provide an updated 'inventory of human lithogenic genes. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000511DOI Listing
March 2019
4 Reads

The genetics of primary biliary cholangitis.

Curr Opin Gastroenterol 2019 Mar;35(2):93-98

Division of Rheumatology Allergy and Clinical Immunology, University of California Davis School of Medicine, Davis, California, USA.

Purpose Of Review: Primary biliary cholangitis (PBC) is a female predominant chronic autoimmune disease of the intrahepatic bile ducts and with a long latent period. It is crucial to understand how genetics contribute to the disease.

Recent Findings: Geo-epidemiological studies in PBC have provided evidence of familial risk; case-control studies and genome wide association studies have identified various human leukocyte antigen (HLA) and non-HLA alleles that are associated with PBC. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000507DOI Listing
March 2019
2 Reads

Intestinal failure-associated liver disease: causes, manifestations and therapies.

Curr Opin Gastroenterol 2019 Mar;35(2):126-133

Department of Clinical Nutrition, 981200 Nebraska Medicine, Omaha, Nebraska, USA.

Purpose Of Review: The goal of this review is to provide updates on the causes, manifestations and therapies IFALD in adults with an emphasis on recent discoveries on pathways of pathogenesis and interventions to reduce the incidence of IFALD.

Recent Findings: IFALD is a multifactorial complication of long-term home parenteral therapy. Although exact pathways are unknown, altered bile acid metabolism, microbiome dysbiosis impact on the gut-liver axis and soybean-based lipid formulations are major drivers of IFALD development. Read More

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http://Insights.ovid.com/crossref?an=00001574-201903000-0001
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http://dx.doi.org/10.1097/MOG.0000000000000503DOI Listing
March 2019
2 Reads

Genetics in biliary atresia.

Curr Opin Gastroenterol 2019 Mar;35(2):73-81

INSERM U1151/CNRS UMR 8253, Institut Necker-Enfants Malades (INEM), Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Purpose Of Review: Biliary atresia is a poorly understood deadly disease. Genetic predisposition factors are suspected albeit not firmly established. This review summarizes recent evidence of genetic alterations in biliary atresia. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000509DOI Listing
March 2019
4 Reads

Editorial: Thought for food: diet and gut health.

Curr Opin Gastroenterol 2019 Mar;35(2):99-100

Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000505DOI Listing
March 2019
1 Read

Modifier genes in cystic fibrosis-related liver disease.

Curr Opin Gastroenterol 2019 Mar;35(2):88-92

INSERM, Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université.

Purpose Of Review: Cystic fibrosis (CF; OMIM 219700) is caused by variations in the cystic fibrosis transmembrane conductance regulator gene. CF-related liver disease (CFLD) affects approximately one-third of patients with CF, but the severity of CFLD is highly variable. This review provides the latest knowledge in the pathophysiology and CF genetic modifier research in CFLD. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000508DOI Listing
March 2019
5 Reads

Food allergy: what it is and what it is not?

Authors:
Chen Hsing Lin

Curr Opin Gastroenterol 2019 Mar;35(2):114-118

Division of Allergy and Immunology, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Purpose Of Review: Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food intolerance, certain gastrointestinal or systemic diseases are often confused with or mislabeled as food allergy because of symptomatic similarity and general improvement from food avoidance. The differences between these diseases are crucial. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000506DOI Listing
March 2019
16 Reads

Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2019 Mar;35(2):107-113

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000502DOI Listing
March 2019
4 Reads

Diet and colon: what matters?

Curr Opin Gastroenterol 2019 Mar;35(2):101-106

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Purpose Of Review: Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. This review focuses on dietary patterns to describe the complexity of dietary diversity and overall food consumption and to examine the relationship between dietary patterns and risk of CRC. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349481PMC
March 2019
11 Reads

Bowel preparation for colonoscopy: what is best and necessary for quality?

Curr Opin Gastroenterol 2019 Jan;35(1):51-57

Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Purpose Of Review: Colonoscopy is recognizably, the best colon cancer prevention test, provided the quality of the preparation is adequate for detection of precancerous polyps but also allowing for accurate identification of margins, thereby facilitating complete endoscopic resection. As there are many aspects effecting colon prep outcomes, it is timely to review new standards for optimizing outcomes, including product selection based on patient demographics.

Recent Findings: New national guidelines have set a minimum quality threshold for adequacy and also defined a split day delivery for oral options as the "standard of care". Read More

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http://dx.doi.org/10.1097/MOG.0000000000000494DOI Listing
January 2019
1 Read
4.289 Impact Factor

Editorial: From eosinophils to serrated adenomas and beyond: late breaking news from the dark continent.

Curr Opin Gastroenterol 2019 Jan;35(1):25-26

Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000496DOI Listing
January 2019
1 Read

Helicobacter pylori resistance to current therapies.

Curr Opin Gastroenterol 2019 Jan;35(1):6-13

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Purpose Of Review: Helicobacter pylori eradication rates have fallen in recent years, mainly because of the emergence of antibiotic-resistant infections. Indeed the WHO has recently designated clarithromycin-resistant H. pylori infection a high priority for antibiotic resistance research and development. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000497DOI Listing
January 2019
18 Reads

Eosinophilic colitis and colonic eosinophilia.

Curr Opin Gastroenterol 2019 Jan;35(1):42-50

Faculty of Health and Medicine, School of Medicine & Public Health, University of Newcastle, Callaghan, Australia.

Purpose Of Review: Eosinophilic colitis is a rare condition, with a prevalence rate in the USA of 2-3/100 000 persons (0.003%), but diagnosed in 0.1% of biopsies in those colonoscoped for diarrhoea. Read More

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http://Insights.ovid.com/crossref?an=00001574-900000000-9923
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http://dx.doi.org/10.1097/MOG.0000000000000492DOI Listing
January 2019
35 Reads

The dark side of the colon: current issues surrounding the significance, prevalence, detection, diagnosis and management of serrated polyps.

Curr Opin Gastroenterol 2019 Jan;35(1):34-41

Brigham and Women's Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Hyperplastic polyps, once considered to have no malignant potential, are now recognized to be part of a larger group of polyps known as serrated polyps. Serrated polyps can progress to CRC through an epigenetic pathway known as CpG Island Methylator Phenotype (CIMP), characterized by hypermethylation of specific DNA regions such as the promoter regions of the DNA mismatch repair genes like MLH1. The CIMP pathway is tightly linked with mutations of the oncogene BRAF. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000495DOI Listing
January 2019
4 Reads

Excluding irritable bowel syndrome in the inflammatory bowel disease patient: how far to go?

Curr Opin Gastroenterol 2019 Jan;35(1):58-62

Division of Gastroenterology, Hepatology, and Nutrition, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Purpose Of Review: Irritable bowel syndrome (IBS) is among the most commonly encountered conditions in primary care and gastroenterology. There is ample evidence that an IBS diagnosis based on symptom-based criteria and exclusion of alarm features that would otherwise support diagnostic testing is accurate and durable. For many clinicians, however, IBS remains a diagnosis of exclusion because of concern surrounding missed diagnoses of inflammatory bowel disease (IBD) or other organic gastrointestinal diseases. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000493DOI Listing
January 2019
11 Reads

Irritable bowel syndrome and colonic diverticular disease: overlapping symptoms and overlapping therapeutic approaches.

Curr Opin Gastroenterol 2019 Jan;35(1):27-33

Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.

Purpose Of Review: Irritable bowel syndrome (IBS) is a common symptomatic disorder in the Western world and colonic diverticula are also prevalent; however, relationships between IBS-type symptoms and diverticula have been a source of much debate. Our goal was to reassess these relationships in the light of new data.

Recent Findings: On removing from consideration clinical scenarios which are directly related to diverticula (i. Read More

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http://Insights.ovid.com/crossref?an=00001574-900000000-9923
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http://dx.doi.org/10.1097/MOG.0000000000000499DOI Listing
January 2019
13 Reads

Comparison of the 2010 and 2017 Infectious Diseases Society of America guidelines on the diagnosis and treatment of Clostridium difficile infection.

Curr Opin Gastroenterol 2019 Jan;35(1):20-24

Microbiology, Leeds Teaching Hospitals NHS Trust & University of Leeds, Leeds, UK.

Purpose Of Review: To highlights the key changes in the updated Infectious Diseases Society of America and Society for Healthcare Epidemiology of America guidelines with respect to the diagnosis and treatment of Clostridium difficile infection (CDI).

Recent Findings: CDI continues as a major threat to healthcare institutions and as a community-associated infection related primarily to antibiotic exposure. Infectious Diseases Society of America/Society for Healthcare Epidemiology of America produced extensive CDI guidelines in 2010; in 2018, updated guidance has been published. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000489DOI Listing
January 2019
8 Reads

Control of norovirus infection.

Curr Opin Gastroenterol 2019 Jan;35(1):14-19

Modelling, Evidence and Policy Research Group, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne.

Purpose Of Review: The purpose of the review is to provide an update on control measures for norovirus (NoV), which is the most commonly implicated pathogen in acute gastroenteritis and outbreaks, causing major disruption in nurseries, schools, hospitals and care homes.

Recent Findings: Important developments include the discovery that virus particles, previously considered to be the infectious unit, also occur in clusters, which appear to be more virulent than individual virus particles; a working culture system using human stem-cell derived enteroids; promising results from early phase clinical trials of candidate NoV vaccines, which appear to be safe and immunogenic; chronic NoV affects patients with primary and secondary immune deficiencies. Although several treatments have been used none are supported by well designed clinical trials; infection control procedures are effective if properly implemented. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000491DOI Listing
January 2019
31 Reads

Irritable bowel syndrome following Clostridium difficile infection.

Curr Opin Gastroenterol 2019 Jan;35(1):1-5

Microbiology, Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, UK.

Purpose Of Review: The aim of this review was to provide an overview of the current understanding of the diagnosis, pathophysiology, and the role of the gut microbiome in Clostridium difficile infection (CDI)-related postinfectious irritable bowel syndrome (PI-IBS).

Recent Findings: PI-IBS is a recognized pathological entity and was estimated to affect 1 in 10 patients with infectious enteritis. CDI remains a major healthcare burden worldwide with a one in four chance of recurrence of symptoms following treatment. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000490DOI Listing
January 2019
13 Reads

Stomach and duodenum.

Curr Opin Gastroenterol 2018 11;34(6):420-421

Gastroenterology Section, Department of Medicine, McGuire VAMC and Virginia Commonwealth University's Medical College of Virginia, Richmond, Virginia, USA.

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http://Insights.ovid.com/crossref?an=00001574-900000000-9925
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http://dx.doi.org/10.1097/MOG.0000000000000477DOI Listing
November 2018
2 Reads