1,140,815 results match your criteria Current Opinion in CPNS Investigational Drugs[Journal]


In vitro genotoxicity assessment of nickel(II) oxide nanoparticles on lymphocytes of human peripheral blood.

J Appl Toxicol 2019 Feb 14. Epub 2019 Feb 14.

Toxicology Lab, Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.

The current study was intended to elucidate the cytotoxicity, genotoxicity ability of nickel oxide (NiO) nanoparticles (NPs) and assessment of preliminary mechanism of the toxicity. Characterization studies showed that NiO-NPs have a particle size of 17.94 (±3. Read More

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http://doi.wiley.com/10.1002/jat.3784
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http://dx.doi.org/10.1002/jat.3784DOI Listing
February 2019
3 Reads

[Involvement of an extralymphatic organ in Hodgkin's lymphoma].

Authors:
Pierre Einwaller

Aktuelle Urol 2019 Feb 14. Epub 2019 Feb 14.

Alexianer Krefeld GmbH, Klinik für Urologie und Kinderurologie, Krefeld.

This case report describes the rare entity of Hodgkin's lymphoma manifesting itself in an extralymphatic organ. To rule out a second malignancy, we performed a transurethral resection of the urinary bladder (TUR-B) in our urology department, confirming the histological findings. After that, the patient received oncological treatment based on the current guidelines. Read More

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http://dx.doi.org/10.1055/a-0834-6027DOI Listing
February 2019

Health Technology Assessments in Radiology in Germany: Lack of Demand, Lack of Supply.

Rofo 2019 Feb 14. Epub 2019 Feb 14.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.

Background:  Health technology assessments (HTAs) are an interdisciplinary method to support sustainable, evidence-based healthcare decisions. They systematically assess medical products, procedures, and technologies with respect to medical, economic, legal, social, and ethical aspects.

Method:  This review analyzes the current use of HTAs in radiology in Germany and discusses challenges associated with HTAs. Read More

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http://dx.doi.org/10.1055/a-0838-6253DOI Listing
February 2019

Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

Int Arch Allergy Immunol 2019 Feb 14:1-6. Epub 2019 Feb 14.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Republic of

Background: We conducted a meta-analysis to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Methods: A systematic literature search identified studies on adult patients with anaphylaxis and a subsequent biphasic reaction due to various causes that contained sufficient data to extract outcomes. The outcomes were pooled using a random-effects model. Read More

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http://dx.doi.org/10.1159/000496092DOI Listing
February 2019

The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease.

Neuroimage Clin 2019 Feb 3;22:101708. Epub 2019 Feb 3.

Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain. Electronic address:

The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101708DOI Listing
February 2019

Nickel molybdate nanorods supported on three-dimensional, porous nickel film coated on copper wire as an advanced binder-free electrode for flexible wire-type asymmetric micro-supercapacitors with enhanced electrochemical performances.

J Colloid Interface Sci 2019 Feb 7;542:325-338. Epub 2019 Feb 7.

Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran; Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, Iran. Electronic address:

Wire-shaped micro-supercapacitors attracted extensive attentions in next-generation portable and wearable electronics, due to advantages of miniature size, lightweight and flexibility. Herein, NiMoO nanorods supported on Ni film coated Cu wire are successfully fabricated thorough direct deposition of Ni film onto Cu wire as the conductive substrate, followed by growth of the NiMoO nanorods on Ni film coated Cu wire substrate by means a hydrothermal annealing process. The prepared 3D, porous electrode demonstrates extremely high areal specific capacitance of 12. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.02.019DOI Listing
February 2019

In vitro metabolic profiles of motolimod by using liquid chromatography tandem mass spectrometry: Metabolic stability, metabolite characterization and species comparison.

J Pharm Biomed Anal 2019 Feb 7;167:90-99. Epub 2019 Feb 7.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Motolimod (VTX-2337) is an agonist of toll-like receptor 8 (TLR8) with potential immune-stimulating and antineoplastic activities. The purpose of this study was to investigate the in vitro metabolic profiles of VTX-2337. The average in vitro T values were 6. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.009DOI Listing
February 2019

Climate-growth relationships in a Larix decidua Mill. network in the French Alps.

Sci Total Environ 2019 Feb 5;664:554-566. Epub 2019 Feb 5.

Retired from Aix Marseille Université, CNRS, Ministère de la Culture et de la Communication, CCJ UMR 7299, 13094 Aix en Provence, France.

A better understanding of the respective role of key climatic variables on tree growth is crucial for an accurate assessment of how ongoing global changes may affect both dynamics and distribution of forest tree species in the future. The aim of this study was (i) to explore growth patterns of European larch (Larix decidua Mill.) through a network of tree-ring chronologies developed for the French Alps and (ii) to identify the main climatic drivers explaining radial growth. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.404DOI Listing
February 2019

Experimental and Monte Carlo characterization of radionuclidic impurities originated from proton irradiation of [O]HO in a modern medical cyclotron.

Appl Radiat Isot 2019 Jan 31;146:84-89. Epub 2019 Jan 31.

INSTM, Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, Unità di Pavia, Via Taramelli 12, I-27100, Pavia, Italy.

In this work we present a characterization of the radionuclidic impurities originated by proton irradiation of enriched water [O]HO in a medical cyclotron through Monte Carlo simulations and experimental measurements. A set of standard samples of enriched water loaded in the cyclotron target cell have been irradiated at 30 μA proton current for 1 h each and, after an appropriate cooling time, measured by HPGe gamma spectrometry. In this way it was possible to study the direct release of radionuclidic impurities from target components as well as the release as a function of target ageing. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.01.026DOI Listing
January 2019

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey.

J Proteomics 2019 Feb 11. Epub 2019 Feb 11.

Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany. Electronic address:

We report on the variable venom composition of a population of the Caucasus viper (Vipera kaznakovi) in Northeastern Turkey. We applied a combination of venom gland transcriptomics, and de-complexing bottom-up and top-down venomics. In contrast to sole bottom-up venomics approaches and gel or chromatography based venom comparison, our combined approach enables a faster and more detailed comparison of venom proteomes from multiple individuals. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.02.004DOI Listing
February 2019

G1P[8] Rotavirus in children with severe diarrhea in the post-vaccine introduction era in Brazil: Evidence of reassortments and structural modifications of the antigenic VP7 and VP4 regions.

Infect Genet Evol 2019 Feb 11. Epub 2019 Feb 11.

Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brazil. Electronic address:

Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P[8] remains associated with >50% of gastroenteritis cases in this age group. The aim of this study was to assess the genetic variability of G1P[8] strains detected in children with severe diarrhea in Belém, Pará, Brazil, during the post-rotavirus vaccine introduction era. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.009DOI Listing
February 2019

Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, 90741, Taiwan. Electronic address:

Erianin is the major bibenzyl compound found in Dendrobium chrysotoxum Lindl. The current study was designed to investigate the protective effects of erianin on high glucose-induced injury in cultured renal tubular epithelial cells (NRK-52E cells) and determine the possible mechanisms for its effects. NRK-52E cells were pretreated with erianin (5, 10, 25 or 50 nmol/L) for 1 h followed by further exposure to high glucose (30 mmol/L, HG) for 48 h. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.021DOI Listing
February 2019

High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan. Electronic address:

Clinical evidence indicates that major depression is a common comorbidity of chronic pain, including neuropathic pain. However, the cellular basis for chronic pain-mediated major depression remains unclear. High-mobility group box 1 protein (HMGB1) has a key role in innate immune responses and appears to be have a role in mediating diverse disorders, including neuropathic pain and depression. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.005DOI Listing
February 2019

The predictive value of neural reward processing in exposure therapy outcome: Results from a randomized controlled trial.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, the Netherlands; Faculty of Psychology, Center for Experimental and Learning Psychology, University of Leuven, Leuven, Belgium.

Background: Exposure is the gold standard treatment for phobic anxiety and is thought to represent the clinical application of extinction learning. Reward sensitivity might however also represent a predictive factor for exposure therapy outcome, as this therapy promotes positive experiences and involves positive comments by the therapist. We hypothesized that high reward sensitivity, as expressed by elevated reward expectancy and reward value, can be associated with better outcome to exposure therapy specifically. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.002DOI Listing
February 2019

Measles outbreaks in Italy: A paradigm of the re-emergence of vaccine-preventable diseases in developed countries.

Authors:
Alessandro Siani

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

School of Biological Sciences, University of Portsmouth, Portsmouth, UK. Electronic address:

Over the last decade, outbreaks of vaccine-preventable diseases have been reported in developed countries around the world. In particular, measles outbreaks have been ongoing in the European Union since 2017, with the majority of cases concentrated in Romania and Italy. Measles has been identified as a powerful indicator of the status of vaccination programs in a region, as outbreaks have been reported to quickly emerge as a result of underlying problems in the immunisation routine. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.011DOI Listing
February 2019

Identification and transformation difficulty in problem solving: Electrophysiological evidence from chunk decomposition.

Biol Psychol 2019 Feb 11. Epub 2019 Feb 11.

Research Centre for Brain Function and Psychological Science, Shenzhen University, Shenzhen, China; Shenzhen Institute of Neuroscience, Shenzhen, China; Institute of Affective and Social Neuroscience, Shenzhen University, Shenzhen, China.

A wealth of studies have investigated how to overcome experience-based constraints in creative problem solving. One such experience-based constraint is the tendency for people to view tightly organized visual stimuli as single, unified percepts, even when decomposition of those stimuli into component parts (termed chunk decomposition) would facilitate problem solving. The current study investigates the neural underpinnings of chunk decomposition in creative problem solving by analyzing event-related potentials. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2019.02.004DOI Listing
February 2019
3.403 Impact Factor

Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells.

Exp Cell Res 2019 Feb 11. Epub 2019 Feb 11.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

Extracellular vesicles (EVs) and their interactions with recipient cells constitute a rapidly growing research area. However, due to the limitations in current methodologies, the mechanisms of these interactions are still unclear. Microscopic studies of EVs are challenging, because their typical diameter is near the resolution limit of light microscopy, and electron microscopy has restricted possibilities for protein labelling. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.004DOI Listing
February 2019

Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

J Mol Biol 2019 Feb 11. Epub 2019 Feb 11.

Group of Stem Cells and Modeling of Neurodegeneration, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Grønnegårdsvej 7, 1870C. Electronic address:

Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD) are neurodegenerative disorders with clear similarities regarding their clinical, genetic and pathological features. Both are progressive, lethal disorders, with no current curative treatment available. Several genes correlated with ALS and FTD are implicated in the same molecular pathways. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.02.004DOI Listing
February 2019

Insecticide resistance in Aedes albopictus Skuse from sub-Himalayan districts of West Bengal, India.

Acta Trop 2019 Feb 11. Epub 2019 Feb 11.

Insect Biochemistry and Molecular Biology Laboratory, Department of Zoology, University of North Bengal, Raja Ramohunpur, P.O. North Bengal University, Siliguri, 734013, District - Darjeeling, West Bengal, India. Electronic address:

Dengue is one of the most rapidly spreading infectious diseases prevalent throughout the tropical and sub-tropical regions of the world. In absence of specific medications and vaccines, the sole method of disease prevention relies on vector control mainly using insecticides. But with the advent of Insecticide resistance, worldwide vector control programs are facing failure. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.007DOI Listing
February 2019

Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

Chem Biol Interact 2019 Feb 7. Epub 2019 Feb 7.

Ramboll US Corporation, Research Triangle Park, NC, USA.

Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy. Initial discovery that DNA mutation was the root of cancer led quickly to regulatory processes that assumed such a simple relationship could be described with a linear approach. This linear, no threshold approach has since become the default approach to risk assessment of chemicals with carcinogenic potential. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.025DOI Listing
February 2019

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019

The importance of early peanut ingestion in the prevention of peanut allergy.

Expert Rev Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

a Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai , One Gustave Levy Pl, New York , NY 10128 , USA.

Introduction: Peanut allergy appears to have increased in prevalence, is often severe and is typically life-long. Therefore, reducing its incidence through a primary prevention strategy is a priority. Guidelines on peanut introduction have evolved with time and given evidence of peanut allergy risk reduction with early infant ingestion exposure, the current US advice promotes early introduction for infants, particularly targeting those at highest risk. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1582331DOI Listing
February 2019

Update on central precocious puberty: from etiologies to outcomes.

Expert Rev Endocrinol Metab 2019 Feb 12:1-8. Epub 2019 Feb 12.

b Department of Pediatrics/Division of Pediatric Endocrinology and Diabetology , Riley Hospital for Children, Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: Precocious puberty (PP) is one of the most common reasons for referral to pediatric endocrinologists. Gonadotropin-releasing hormone analogs (GnRHas) are the gold standard for the treatment of central precocious puberty (CPP) and have an impressive record of safety and efficacy. However, ongoing refinements in diagnosis and management continue to lead to important advancements in clinical care. Read More

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http://dx.doi.org/10.1080/17446651.2019.1575726DOI Listing
February 2019

[Sandflies Fauna of the Focus of Keur Moussa: Current Data on Diversity and Seasonal Variations (Thies, Senegal)].

Bull Soc Pathol Exot 2018 ;111(1):38-45

Laboratoire de zoologie des invertébrés terrestres, Institut fondamental d'Afrique noire Cheikh-Anta-Diop, université Cheikh-Anta-Diop, B.P. 206, Dakar, Sénégal.

An inter-epidemic oversight was conducted in the cutaneous leishmaniasis focus of Keur Moussa (Thies region) between June 2015 and October 2016, more than 20 years after the last epidemic. The three sampling methods (adhesive traps, CDC light traps, and indoor pyrethroids sprays) allowed the capture of 1,746 sand flies belonging to 2 genera and 24 species, those involved in the transmission of leishmaniasis in Senegal, as well as 11 new species for the focus. The vector of human cutaneous leishmaniasis in Senegal, Neveu-Lemaire, 1906, represents 10. Read More

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http://dx.doi.org/10.3166/bspe-2018-0012DOI Listing
January 2018

A 65-Year Follow-up of a Judet Prosthesis.

Orthopedics 2019 Feb 14:1-3. Epub 2019 Feb 14.

The Judet polymethylmethacrylate hip hemiarthroplasty can be considered a major step in the development of the current total hip replacement. It was designed by the Judet brothers and first implanted in 1946. Although initial results were encouraging, the procedure was abandoned years later because of breakages and wear of the acrylic material. Read More

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http://dx.doi.org/10.3928/01477447-20190211-06DOI Listing
February 2019

Reevaluating a Standardized Sedation Weaning Protocol for Pediatric Laryngotracheal Reconstruction for Continuous Quality Improvement.

JAMA Otolaryngol Head Neck Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye & Ear Infirmary, Boston, Masschusetts.

Importance: Health care organizations are complex and evolving systems. To date, longitudinal evaluation to ensure the sustainability of quality improvement (QI) initiatives has been missing from the otolaryngology literature. We sought to reassess perioperative management of laryngotracheal reconstruction, which requires adequate sedation. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.4348DOI Listing
February 2019

Integrating genetic and physical positions of the anthracnose resistance genes described in bean chromosomes Pv01 and Pv04.

PLoS One 2019 14;14(2):e0212298. Epub 2019 Feb 14.

Plant Genetic Group, Area of Horticultural and Forest Crops, SERIDA, Villaviciosa Asturias, Spain.

A complex landscape of anthracnose resistance genes (Co-) located at the telomeric regions of the bean chromosomes Pv01 and Pv04 has been reported. The aim of this work was to investigate the genetic and physical positions of genes conferring resistance to races 6, 38, 39, 357, 65, and 73 as well as the relationships among the resistance genes identified herein and the previously described Co- genes in these telomeric regions. The linkage analysis using a genetic map of 497 SNPs from the recombinant inbred line population Xana/BAT93 revealed that the gene conferring resistance to race 65 in cultivar Xana (Co-165-X) was located in the Co-1 cluster, at the distal end of chromosome Pv01. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212298PLOS
February 2019

A natural history model for planning prostate cancer testing: Calibration and validation using Swedish registry data.

PLoS One 2019 14;14(2):e0211918. Epub 2019 Feb 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Recent prostate cancer screening trials have given conflicting results and it is unclear how to reduce prostate cancer mortality while minimising overdiagnosis and overtreatment. Prostate cancer testing is a partially observable process, and planning for testing requires either extrapolation from randomised controlled trials or, more flexibly, modelling of the cancer natural history. An existing US prostate cancer natural history model (Gulati et al, Biostatistics 2010;11:707-719) did not model for differences in survival between Gleason 6 and 7 cancers and predicted too few Gleason 7 cancers for contemporary Sweden. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211918PLOS
February 2019

Effect of transcranial direct current stimulation on the number of smoked cigarettes in tobacco smokers.

PLoS One 2019 14;14(2):e0212312. Epub 2019 Feb 14.

Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia.

Background: Recent studies reported that transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) reduced craving and cigarette smoking. We aimed to evaluate whether 3 sessions of tDCS over the DLPFC modulate cigarette smoking which is a critical factor in tobacco smokers.

Methods: In a double-blinded, sham-controlled, parallel experimental study, 22 participants who wished to quit smoking received tDCS with the cathodal over the right DLPFC and anodal over the left DLPFC based on the 10-20 EEG international system (F4, F3) at an intensity of 1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212312PLOS
February 2019

The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.

PLoS One 2019 14;14(2):e0212283. Epub 2019 Feb 14.

Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.

Objective: To investigate the association between current CD4+ T-cell count and CD4/CD8+ ratio with severity of frailty among people aging with HIV.

Methods: Cross-sectional observational study analysing data from all study visits in the ongoing prospective Modena HIV Metabolic Clinic Cohort between 2006 and 2015. Frailty severity was assessed using a frailty index (FI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212283PLOS
February 2019
1 Read

Linking childhood emotional abuse and depressive symptoms: The role of emotion dysregulation and interpersonal problems.

PLoS One 2019 14;14(2):e0211882. Epub 2019 Feb 14.

Department of Psychology, Miami University, Oxford, Ohio, United States of America.

Childhood abuse is a major public health problem that has been linked to depression in adulthood. Although different types of childhood abuse often co-occur, few studies have examined their unique impact on negative mental health outcomes. Most studies have focused solely on the consequences of childhood physical or sexual abuse; however, it has been suggested that childhood emotional abuse is more strongly related to depression. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211882PLOS
February 2019

Generation and characterization of D-dimer specific monoclonal antibodies for use in latex agglutination test.

PLoS One 2019 14;14(2):e0212104. Epub 2019 Feb 14.

Laboratory of Immunology, Veterinary Diagnostic Directorate of the National Food Chain Safety Office, Budapest, Hungary.

The commercially available D-dimer assays used in the clinical practice often show differences in the results, and their specificity and sensitivity are rather unsatisfactory. Our aim was to develop a new monoclonal antibody against D-dimer with a proper specificity, and estimating its suitability using in a latex agglutination diagnostic test. Monoclonal antibodies were generated using hybridoma technology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212104PLOS
February 2019

An O(n) method of calculating Kendall correlations of spike trains.

Authors:
William Redman

PLoS One 2019 14;14(2):e0212190. Epub 2019 Feb 14.

Dynamical Neuroscience Program, UC Santa Barbara, Santa Barbara, CA, United States of America.

The ability to record from increasingly large numbers of neurons, and the increasing attention being paid to large scale neural network simulations, demands computationally fast algorithms to compute relevant statistical measures. We present an O(n) algorithm for calculating the Kendall correlation of spike trains, a correlation measure that is becoming especially recognized as an important tool in neuroscience. We show that our method is around 50 times faster than the O (n ln n) method which is a current standard for quickly computing the Kendall correlation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212190PLOS
February 2019

Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans.

PLoS Genet 2019 Feb 14;15(2):e1007975. Epub 2019 Feb 14.

Department of Genetics, Harvard Medical School, Boston, MA, United States of America.

Chemicals that are highly prevalent in our environment, such as phthalates and pesticides, have been linked to problems associated with reproductive health. However, rapid assessment of their impact on reproductive health and understanding how they cause such deleterious effects, remain challenging due to their fast-growing numbers and the limitations of various current toxicity assessment model systems. Here, we performed a high-throughput screen in C. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007975DOI Listing
February 2019

Vital Signs: Tobacco Product Use Among Middle and High School Students - United States, 2011-2018.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):157-164. Epub 2019 Feb 15.

Introduction: Tobacco use is the leading cause of preventable disease and death in the United States; nearly all tobacco product use begins during youth and young adulthood.

Methods: CDC, the Food and Drug Administration, and the National Cancer Institute analyzed data from the 2011-2018 National Youth Tobacco Surveys to estimate tobacco product use among U.S. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806e1DOI Listing
February 2019

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
January 2019

Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

H Teede, Monash Centre for Health Research and Implementation, Monash University, Clayton, Australia.

Objective: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-050
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http://dx.doi.org/10.1530/EC-18-0502DOI Listing
February 2019
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Google Trends predicts present and future plague cases during the plague outbreak in Madagascar: insights and implications from an infodemiological study.

JMIR Public Health Surveill 2019 Jan 18. Epub 2019 Jan 18.

Tel Aviv University, Tel Aviv, IL.

Background: Plague is a highly infectious zoonotic disease caused by the bacillus Yersinia pestis. Three major forms of the disease are known: bubonic, septicemic, and pneumonic plague. Though being strictly related to past history, plague still represents a global public health concern. Read More

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http://dx.doi.org/10.2196/13142DOI Listing
January 2019

Pharmacologic Management of Aneurysms.

Circ Res 2019 Feb;124(4):631-646

Division of Vascular Surgery, School of Medicine and Public Health, University of Wisconsin, Madison (J.S.M.).

Current management of aortic aneurysms relies exclusively on prophylactic operative repair of larger aneurysms. Great potential exists for successful medical therapy that halts or reduces aneurysm progression and hence alleviates or postpones the need for surgical repair. Preclinical studies in the context of abdominal aortic aneurysm identified hundreds of candidate strategies for stabilization, and data from preoperative clinical intervention studies show that interventions in the pathways of the activated inflammatory and proteolytic cascades in enlarging abdominal aortic aneurysm are feasible. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312439DOI Listing
February 2019

Genetics of Thoracic and Abdominal Aortic Diseases.

Circ Res 2019 Feb;124(4):588-606

From the Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School; University of Texas Health Science Center at Houston (A.P., D.M.M.).

Dissections or ruptures of aortic aneurysms remain a leading cause of death in the developed world, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Genetic variants predispose individuals to these aortic diseases. In the case of thoracic aortic aneurysm and dissections (thoracic aortic disease), genetic data can be used to identify some at-risk individuals and dictate management of the associated vascular disease. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312436DOI Listing
February 2019

Inspiratory Muscle Activation via Ventral Lower Thoracic High Frequency Spinal Cord Stimulation.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Department of Physical Medicine and Rehabilitation, MetroHealth Medical Center, Case Western Reserve University, United States.

In animals, high frequency spinal cord stimulation (HF-SCS) applied on the ventral epidural surface at T2 level results in negative airway pressure generation consistent with inspiratory muscle activation. In the present study, in anesthetized dogs, we found that ventral HF-SCS (500Hz) applied at all thoracic levels resulted in negative airway pressure generation. In the region of the lower thoracic spinal cord, negative airway pressure generation was most pronounced at the T9 level. Read More

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http://dx.doi.org/10.1152/japplphysiol.01054.2018DOI Listing
February 2019

Traditional materials from new sources - conflicts in analytical methods for calcium carbonate.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Feb 14:1-8. Epub 2019 Feb 14.

a Biomolecular and Materials Interface Research Group, School of Science and Technology , Nottingham Trent University , Nottingham , UK.

Calcium carbonate (E170) is a common food and pharmaceutical additive/ingredient. In addition to a source of calcium, the carbonate has uses including as a colour, acidity regulator and bulking agent. Globally, a range of regulatory agencies and pharmacopoeia control the analyses and specification of additives in food, supplements, pharmaceutical substances and excipients. Read More

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http://dx.doi.org/10.1080/19440049.2019.1571288DOI Listing
February 2019

DYSGLYCEMIA-BASED CHRONIC DISEASE: AN AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS POSITION STATEMENT.

Endocr Pract 2018 Nov;24(11):995-1011

The American Association of Clinical Endocrinologists (AACE) has created a dysglycemia-based chronic disease (DBCD) multimorbidity care model consisting of four distinct stages along the insulin resistance-prediabetes-type 2 diabetes (T2D) spectrum that are actionable in a preventive care paradigm to reduce the potential impact of T2D, cardiometabolic risk, and cardiovascular events. The controversy of whether there is value, cost-effectiveness, or clinical benefit of diagnosing and/or managing the prediabetes state is resolved by regarding the problem, not in isolation, but as an intermediate stage in the continuum of a progressive chronic disease with opportunities for multiple concurrent prevention strategies. In this context, stage 1 represents "insulin resistance," stage 2 "prediabetes," stage 3 "type 2 diabetes," and stage 4 "vascular complications. Read More

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http://dx.doi.org/10.4158/PS-2018-0139DOI Listing
November 2018

Biological therapies in lung cancer treatment: using our immune system as an ally to defeat the malignancy.

Expert Opin Biol Ther 2019 Feb 14. Epub 2019 Feb 14.

a Institute for Health Science Research Germans Trias i Pujol (IGTP) , Badalona , Spain.

Introduction: Biological therapies, with immunotherapy leading the field, have arisen as one of the quickest expanding areas of research for cancer treatment in the last few years. The clear benefits for patients are undeniable, satisfying the long-awaited necessity of a target-specific therapy. However, its full potential remains still unexploited due to a lack of response in a majority of patients and pending reliable biomarkers. Read More

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http://dx.doi.org/10.1080/14712598.2019.1582635DOI Listing
February 2019

Current and Common Definitions of Treatment-Resistant Depression: Findings from a Systematic Review and Qualitative Interviews.

Can J Psychiatry 2019 Feb 14:706743719828965. Epub 2019 Feb 14.

1 University of Calgary, Calgary, Alberta.

Objective:: No universal definition for treatment-resistant depression (TRD) exists. This lack of consensus reduces the generalizability of study findings and limits the ability to study TRD. In addition, anecdotally, there may be a difference between the definitions of TRD within research and those applied in practice. Read More

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http://dx.doi.org/10.1177/0706743719828965DOI Listing
February 2019

Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model.

J Med Chem 2019 Feb 14. Epub 2019 Feb 14.

Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa due to its huge impact on livestock health. Existing therapies including those based upon Minor Groove Binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy in some places due to the emergence of resistant parasites. Consequently, the need for new chemotherapies is urgent. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01847DOI Listing
February 2019

A Practical ELISA for Azaspiracids in Shellfish via Development of a New Plate-Coating Antigen.

J Agric Food Chem 2019 Feb 14. Epub 2019 Feb 14.

Norwegian Veterinary Institute , P.O. Box 750 Sentrum, N-0106 Oslo , Norway.

Azaspiracids (AZAs) are a group of biotoxins that appear periodically in shellfish and can cause food poisoning in humans. Current methods for quantifying the regulated AZAs are restricted to LC-MS but are not well suited to detecting novel and unregulated AZAs. An ELISA method for total AZAs in shellfish was reported recently, but unfortunately, it used relatively large amounts of the AZA-1-containing plate-coating conjugate, consuming significant amounts of pure AZA-1 per assay. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b05652DOI Listing
February 2019

Identifying new AMP-activated protein kinase inhibitors that protect against ischemic brain injury.

ACS Chem Neurosci 2019 Feb 14. Epub 2019 Feb 14.

We recently reported that AMP-activated protein kinase (AMPK) contributes to zinc-induced neuronal death by inducing Bim, a pro-apoptotic Bcl-2 homology domain 3-only protein, in a liver kinase B1 (LKB1)-dependent manner. Current data suggest AMPK plays key roles in excitotoxicity and ischemic brain injury, with zinc neurotoxicity representing at least one mechanism of ischemic neuronal death. Inhibition of AMPK could be a viable therapeutic strategy to prevent ischemic brain injury following stroke. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00654DOI Listing
February 2019

Iodinated contrast-induced sialadenitis: a review of the literature and sonographic findings in a clinical case.

J Ultrason 2018 ;18(75):359-364

Department of Radiology, University Hospital of Verona, Polo Chirurgico "Confortini" , Verona , Italy.

Swelling of the salivary glands, also known as iodide or iodine mumps, is a rare adverse reaction to administration of iodine, a component steadily present in current contrast media and in a variety of medications. We report and compare with published literature the clinical and sonographic findings in a case of iodide mumps that developed after the intravenous administration of iodine-based contrast media for a contrast-enhanced computed tomography scan. The exact pathogenesis is unknown to date: based on sonographic appearance, we support the hypothesis of an acute inflammatory condition elicited by iodine accumulation in the salivary glands. Read More

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http://dx.doi.org/10.15557/JoU.2018.0053DOI Listing
January 2018
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