1,158,697 results match your criteria Current Opinion in CPNS Investigational Drugs[Journal]


Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

School-level factors associated with obesity: A systematic review of longitudinal studies.

Obes Rev 2019 Apr 23. Epub 2019 Apr 23.

Department of Child & Family Studies, College of Behavioral & Community Sciences, University of South Florida, Tampa, Florida.

Although school has been an important intervention venue for obesity prevention, the role of school-level factors in obesity development or prevention has not been well-documented. This study aimed to systematically examine the current evidence on school-level factors associated with obesity outcomes in longitudinal studies. The literature search was performed in PubMed, EMBASE, CINHAL, and PsycINFO. Read More

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http://dx.doi.org/10.1111/obr.12852DOI Listing

Understanding the Heterogeneity of Labor and Delivery Units: Using Design Thinking Methodology to Assess Environmental Factors that Contribute to Safety in Childbirth.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California.

Objective:  There is limited research exploring the relationship between design and patient safety outcomes, especially in maternal and neonatal care. We employed design thinking methodology to understand how the design of labor and delivery units impacts safety and identified spaces and systems where improvements are needed.

Study Design:  Site visits were conducted at 10 labor and delivery units in California. Read More

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http://dx.doi.org/10.1055/s-0039-1685494DOI Listing

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

Hull York Medical School, Centre for Atherothrombotic and Metabolic Disease, Hull, United Kingdom of Great Britain and Northern Ireland.

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as platelet-rich plasma and platelet releasate exhibit beneficial biological effects after a sports injury or trauma when administered locally by intramuscular injections. At present, treatment of the public, patients and athletes with platelet-based applications is permitted and regulated by the Food and Drug Administration and the World Anti-Doping Agency. Read More

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http://dx.doi.org/10.1055/a-0884-0734DOI Listing

A scalable database of organ doses for common diagnostic fluoroscopy examinations of children: procedures of current practice at the University of Florida.

Phys Med Biol 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Engineering, University of Florida, PO Box 116131, 1275 Center Drive, Gainesville, Florida, 32611-6131, UNITED STATES.

Of all the medical imaging modalities that utilize ionizing radiation, fluoroscopy proves to be the most difficult to assess values of patient organ dose owing to the dynamic and patient-specific nature of the irradiation geometry and its associated x-ray beam characteristics. With the introduction of the radiation dose structured report (RDSR) in the mid-2000s, however, computational tools have been developed to extract patient and procedure-specific data for each irradiation event of the study, and when coupled to a computational phantom of the patient, values of skin and internal organ dose may be assessed. Unfortunately, many legacy and even current diagnostic fluoroscopy units do not have RDSR reporting capabilities, thus limiting these dosimetry reporting advances. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1badDOI Listing

Innate Immune Responses to in the Airway.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey.

is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Read More

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http://dx.doi.org/10.1089/jir.2019.0008DOI Listing

Quality of Lactation Studies Investigating Antidepressants.

Breastfeed Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Pharmacy, Isala, Zwolle, the Netherlands.

The aim of this study was to determine the quality of lactation studies investigating antidepressants in breast milk according to the Food and Drug Administration (FDA) draft guidelines and the article of Begg, published in the official journal of the International Lactation Consultant Association (ILCA). We used PubMed and LactMed for the literature search. Furthermore, cross references were searched for additional studies. Read More

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http://dx.doi.org/10.1089/bfm.2019.0021DOI Listing

Mechanism of Selective Ion Removal in Membrane Capacitive Deionization for Water Softening.

Authors:
Li Wang Shihong Lin

Environ Sci Technol 2019 Apr 23. Epub 2019 Apr 23.

Capacitive deionization (CDI) is an emerging technology selective removal of ions from water. While many studies have reported chemically tailored electrodes for selective ion removal, the selective removal of divalent cations (i.e. Read More

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http://dx.doi.org/10.1021/acs.est.9b00655DOI Listing

High-Temperature and All-Solid-State Flexible Supercapacitors with Excellent Long-Term Stability Based on Porous Polybenzimidazole/Functional Ionic Liquid Electrolyte.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

A high-performance solid-state electrolyte was obtained based on porous polybenzimidazole (pPBI) and ionic liquid (1-(3-trimethoxysilylpropyl)-3 methylimidazole). IL is hydrolyzed to form Si-O-Si networks under acidic conditions, which guarantee the enhanced mechanical properties. The porous structure and Si-O-Si networks improve the acid retention capacity and conductivity simultaneously. Read More

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http://dx.doi.org/10.1021/acsami.9b00452DOI Listing

Synthesis and Electrochemical Study of Mesoporous Nickel-Cobalt Oxides for Efficient Oxygen Reduction.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Development of a cost-effective and efficient electrocatalyst for the sluggish oxygen reduction reaction (ORR) is a crucial challenge for clean energy technologies. In this study, we have synthesized various Ni and Co oxide (NCO) nanomaterials via a facile co-precipitation followed by the calcination method. The morphology of the formed NCO nanomaterials was controlled by varying the percentage of the Ni and Co precursors, leading to the formation of template-free mesoporous spinel phase structure of NixCo3-xO4. Read More

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http://dx.doi.org/10.1021/acsami.8b22351DOI Listing

[Risk factors for uncontrolled asthma in adults].

Rev Alerg Mex 2019 Jan-Mar;66(1):65-75

Secretaría de Salud, Hospital General de México, Servicio de Alergia e Inmunología Clínica, Ciudad de México, México.

Background: Many studies in children had identified risk factors associated with partly or uncontrolled asthma. In adults, factors related to asthma control were not well defined.

Objective: To find the factors related to partly or uncontrolled asthma in adults. Read More

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http://dx.doi.org/10.29262/ram.v66i1.557DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing

The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation.

Liver Transpl 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.

The evolution of nurse practitioners (NP) and physician assistants (PA) in the United States continues to progress. NPs and PAs have expanded from primary care practices, to medical and surgical specialties, provide acute care in hospitals and intensive care units, and serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice. Read More

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http://dx.doi.org/10.1002/lt.25474DOI Listing

The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions.

Transfusion 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. Read More

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http://dx.doi.org/10.1111/trf.15317DOI Listing

Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing

Look at me when I'm talking to you: Selective attention at a multisensory cocktail party can be decoded using stimulus reconstruction and alpha power modulations.

Eur J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

School of Engineering, Trinity Centre for Bioengineering and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.

Recent work using EEG has applied stimulus reconstruction techniques to identify the attended speaker in a cocktail party environment. The success of these approaches has been primarily based on the ability to detect cortical tracking of the acoustic envelope at the scalp level. However, most studies have ignored the effects of visual input, which is almost always present in naturalistic scenarios. Read More

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http://dx.doi.org/10.1111/ejn.14425DOI Listing

Entrustable Professional Activity Utilization: A CERA Study of Family Medicine Residency Program Directors.

Fam Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Family Medicine, College of Medicine, University of Illinois, Chicago, IL.

Background And Objectives: Entrustable professional activities (EPAs) is a novel assessment framework in competency-based medical education. While there are published pilot reports about utilization and validation of EPAs within undergraduate medical education (UME), there is a paucity of research within graduate medical education (GME). This study aimed to explore the landscape of EPAs within family medicine GME, particularly related to the understanding of EPAs, extent of utilization, and benefits and challenges of EPAs implementation as an assessment framework within family medicine residency programs (FMRPs) in the United States. Read More

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http://dx.doi.org/10.22454/FamMed.2019.876961DOI Listing

Coding Family Medicine Residency Clinic Visits, 99213 or 99214? A Residency Research Network of Texas Study.

Fam Med 2019 Apr 23. Epub 2019 Apr 23.

University of Texas Health Science Center at San Antonio, Department of Family and Community Medicine.

Background And Objectives: The purpose of this study was to characterize Current Procedural Terminology (CPT) coding patterns for professional services in family physician (FP) residency clinics.

Methods: Trained assistants directly observed during every other FP-patient encounter in 10 clinics affiliated with eight residencies of the Residency Research Network of Texas. Three investigators later independently coded each visit for the highest code level reasonably allowed. Read More

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http://dx.doi.org/10.22454/FamMed.2019.862757DOI Listing

Trends in Cigar Use in the United States, 2002 to 2016: Diverging Trends by Race/Ethnicity.

Nicotine Tob Res 2019 Apr 23. Epub 2019 Apr 23.

Institute for Implementation Science in Population Health, The City University of New York, New York, NY USA.

Introduction: While there are racial/ethnic differences in cigarette use, little is known about how non-cigarette tobacco use differs among racial/ethnic groups. The current study investigated trends in cigar use from 2002 to 2016, by racial/ethnic group, in nationally representative United States (US) data.

Methods: Data were drawn from the 2002-2016 National Survey on Drug Use and Health (NSDUH) public use data files (total analytic sample n=630,547 including 54,060 past-month cigar users). Read More

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http://dx.doi.org/10.1093/ntr/ntz060DOI Listing

Pregnancy intention and contraceptive use among HIV-positive Malawian women at 4-26 weeks post-partum: A nested cross-sectional study.

PLoS One 2019 23;14(4):e0215947. Epub 2019 Apr 23.

Centers for Disease Control and Prevention, Lilongwe, Malawi.

Background: Avoiding unintended pregnancies through family planning is a WHO strategy for preventing mother to child transmission of HIV (PMTCT) and maternal morbidity/mortality. We investigated factors associated with unintended index pregnancy, unmet contraceptive need, future pregnancy intention and current contraceptive use among Malawian women living with HIV in the Option B+ era.

Methods: Women who tested HIV positive at 4-26 weeks postpartum were enrolled into a cross-sectional study at high-volume Under-5 clinics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215947PLOS
April 2019
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In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.

PLoS One 2019 23;14(4):e0215960. Epub 2019 Apr 23.

Department of Biology, Memorial University of Newfoundland, St. John's, NL, Canada.

In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain. The cpe gene is essential for clavulanic acid production, and the recent crystal structure of its product (Cpe) was shown to also contain an N-terminal isomerase/cyclase-like domain, but the function of the protein remains unknown. In the current study, we show that Cpe is a cytoplasmic protein and that both its N- and C-terminal domains are required for in vivo clavulanic acid production in S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215960PLOS

The association between neck adiposity and long-term outcome.

PLoS One 2019 23;14(4):e0215538. Epub 2019 Apr 23.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Anthropometric indices of obesity (e.g. body mass index, waist circumference and neck circumference) are associated with poor long-term cardiovascular outcome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215538PLOS

MergedTrie: Efficient textual indexing.

PLoS One 2019 23;14(4):e0215288. Epub 2019 Apr 23.

Lucentia Research Group, Department of Software and Computing Systems, University of Alicante, Alicante, Spain.

The accessing and processing of textual information (i.e. the storing and querying of a set of strings) is especially important for many current applications (e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215288PLOS

Out of Africa by spontaneous migration waves.

PLoS One 2019 23;14(4):e0201998. Epub 2019 Apr 23.

Department of Geosciences, Eberhard Karls University Tübingen, Tübingen, Germany.

Hominin evolution is characterized by progressive regional differentiation, as well as migration waves, leading to anatomically modern humans that are assumed to have emerged in Africa and spread over the whole world. Why or whether Africa was the source region of modern humans and what caused their spread remains subject of ongoing debate. We present a spatially explicit, stochastic numerical model that includes ongoing mutations, demic diffusion, assortative mating and migration waves. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201998PLOS

Transcranial direct current stimulation treatment in chronic after-stroke dysphagia: A clinical case.

Psicothema 2019 May;31(2):179-183

Universidad de Almería, Instituto de Neurorehabilitación InPaula.

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that has shown positive effects in a variety of motor diseases including dysphagia. However, its clinical application and underlying microstructural effects are still being researched. We tested whether tDCS applied together with swallowing training could benefit a treatment-resistent patient with dysphagia after a stroke. Read More

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http://dx.doi.org/10.7334/psicothema2018.310DOI Listing

Elevated Swelling-Activated Chloride Current Densities in Hypertrophied Ventricular Myocytes in a Rabbit Heart Failure Model.

Heart Surg Forum 2019 Mar 7;22(2):E107-E111. Epub 2019 Mar 7.

Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: The status of the swelling-activated chloride channel (ICl, swell) during heart failure remains unclear. This study aimed to investigate whether the ICl, swell activity is altered during heart failure and to determine how the ICl, swell influences atrial arrhythmias of the failing heart.

Methods: We established a heart failure rabbit model and analyzed the hemodynamic indicators 8 weeks after myocardial infarction, which include left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVDEP). Read More

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http://dx.doi.org/10.1532/hsf.2255DOI Listing

Is GRADE the Right Choice for Clinical Practice Guidelines Developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation?

Otolaryngol Head Neck Surg 2019 Apr 23:194599819846458. Epub 2019 Apr 23.

2 SUNY Downstate Medical Center, Brooklyn, New York, USA.

Clinical practice guidelines (CPGs), developed to inform clinicians, patients, and policy makers about what constitutes optimal clinical care, are one way of increasing implementation of evidence into clinical practice. Many factors must be considered by multidisciplinary guideline panels, including strength of available evidence, limitations of current knowledge, risks/benefits of interventions, patient values, and limited resources. Grading of Recommendations Assessment, Development and Evaluation (GRADE) is a framework for summarizing evidence that has been endorsed by many national and international organizations for developing CPGs. Read More

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http://dx.doi.org/10.1177/0194599819846458DOI Listing

The effect of acute caffeine ingestion on upper and lower body anaerobic exercise performance.

Eur J Sport Sci 2019 Apr 23:1-8. Epub 2019 Apr 23.

a Centre for Sport, Exercise and Life Sciences , Coventry University , Coventry , UK.

The current study examined the effect of acute caffeine ingestion on mean and peak power production, fatigue index and rating of perceived exertion (RPE) during upper body and lower body Wingate anaerobic test (WANT) performance. Using a double-blind design, 22 males undertook one upper body and one lower body WANT, 60 min following ingestion of caffeine (5 mg*kg) and one upper body and one lower body WANT following ingestion of placebo (5 mg*kg Dextrose). Peak power was significantly higher (P = . Read More

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http://dx.doi.org/10.1080/17461391.2019.1601261DOI Listing

Feasibility of Intensive Ecological Sampling of Tinnitus in Intervention Research.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844968. Epub 2019 Apr 23.

1 Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.

Objective: To assess whether adults with bothersome tinnitus will complete multiple ecological momentary assessments (EMAs) per day, including those during a therapeutic intervention trial. EMA is defined as repeated sampling of subjects' current behaviors and experiences in real time.

Study Design: Twelve-week longitudinal cohort study conducted from August 28, 2017, to December 14, 2017. Read More

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http://dx.doi.org/10.1177/0194599819844968DOI Listing

Hip and Groin Injuries in Professional Basketball Players: Impact on Playing Career and Quality of Life After Retirement.

Sports Health 2019 Apr 23:1941738119838274. Epub 2019 Apr 23.

MedSport, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan.

Background: Professional basketball players are at increased risk of hip and groin pain. Epidemiologic data exist on the prevalence of hip and groin issues among players in the National Basketball Association (NBA), but little is known about how these injuries affect athletes after retirement.

Hypothesis: A high proportion of retired NBA athletes would have hip and/or groin pain. Read More

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http://dx.doi.org/10.1177/1941738119838274DOI Listing

Psychotropic substance abuse and fitness to hold a driving license in Italy.

Traffic Inj Prev 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Forensic Toxicology Division, Department of Health Sciences , University of Florence , Florence , Italy.

Objective: Driving under the influence (DUI) of psychotropic substances is a serious and widespread problem in road safety. All countries try to reduce the impact with legislative controls over the criteria to regain a driver's license after suspension. In many European countries there are mandatory clinical and toxicological examinations required before a license is regranted. Read More

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http://dx.doi.org/10.1080/15389588.2019.1579320DOI Listing

COMPARATIVE EFFICACY AND SAFETY OF THREE CURRENT CLINICAL TREATMENTS FOR GIRLS WITH CENTRAL PRECOCIOUS PUBERTY: A NETWORK META-ANALYSIS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Department of Nutrition, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

: The optimal treatment for girls with central precocious puberty (CPP) is unknown. We conducted a network meta-analysis to evaluate the efficacy and safety of existing treatments to provide credible clinical guidelines. We compared gonadotropin-releasing hormone analogue (GnRHa) therapy, GnRHa plus growth hormone (GH) combination therapy, and no-treatment therapy to treat girls with CPP by performing an electronic search for studies in PubMed, Embase, Chinese National Knowledge Infrastructure databases, and Wanfang Data from their inception until 30 September 2018. Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0008
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http://dx.doi.org/10.4158/EP-2019-0008DOI Listing
April 2019
1 Read

Repetitive hypoglycaemia reduces the activation of glucose responsive neurons in the C1 and C3 medullary brain regions to subsequent hypoglycaemia.

Am J Physiol Endocrinol Metab 2019 Apr 23. Epub 2019 Apr 23.

Department of Physiology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.

The impaired ability of the autonomic nervous system to respond to hypoglycaemia is termed 'hypoglycaemia-associated autonomic failure' (HAAF). This life-threatening phenomenon results from at least two recent episodes of hypoglycaemia, but the pathology underpinning HAAF remains largely unknown. Although naloxone appears to improve hypoglycaemia counter-regulation under controlled conditions, hypoglycaemia prevention remains the current mainstay therapy for HAAF. Read More

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http://dx.doi.org/10.1152/ajpendo.00051.2019DOI Listing

Current Workload Recommendations in Baseball Pitchers: A Systematic Review.

Am J Sports Med 2019 Apr 23:363546519831010. Epub 2019 Apr 23.

Department of Orthopedic Surgery, University of Michigan, Ypsilanti, Michigan, USA.

Background: Several recommendations have been made regarding pitch counts and workload for baseball players of different levels, including Little League, high school, collegiate, and professional baseball. However, little consensus is found in the literature regarding the scientific basis for many of these recommendations.

Purpose: The primary purpose of this study was to summarize the evidence regarding immediate and long-term musculoskeletal responses to increasing pitching workload in baseball pitchers of all levels. Read More

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http://dx.doi.org/10.1177/0363546519831010DOI Listing

Horizontal Instability of the Acromioclavicular Joint: A Systematic Review.

Am J Sports Med 2019 Apr 23:363546519831013. Epub 2019 Apr 23.

Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Background: Injuries to the acromioclavicular (AC) joint are common and should be suspected in patients who have shoulder pain in the region of the acromion and clavicle. Injuries to the AC ligament can cause horizontal instability and are often neglected or underdiagnosed, which can lead to poor patient outcomes.

Purpose: To perform a systematic review of the literature on the diagnosis and treatment of horizontal instability of the AC joint. Read More

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http://dx.doi.org/10.1177/0363546519831013DOI Listing

Correlation between Environmental Monitoring and Product Bioburden.

Biomed Instrum Technol 2019 Jun;53(s2):32-37

Environmental monitoring (EM) has long been used by manufacturers to evaluate the potential microbiological impact from the manufacturing environment on the product produced therein. In the 1890s, Fred B. Kilmer pioneered the principles of asepsis and the need to institute policies to protect a product from environmental particulates and/or microorganisms. Read More

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http://dx.doi.org/10.2345/0899-8205-53.s2.32DOI Listing

One-step in situ synthesis of reduced graphene oxide/Zn-Al layered double hydroxide film for enhanced corrosion protection of magnesium alloys.

Langmuir 2019 Apr 23. Epub 2019 Apr 23.

As an effective and environmentally friendly material for corrosion prevention, layered double hydroxide (LDH) films have usually been degraded due to their inherent microporous structure. In this study, graphene derivatives were employed to enhance the corrosion resistance of LDH films. After ultrasonic treatment of a reaction solution mixture containing graphene oxide (GO) powder, a reduced graphene oxide/zinc-aluminum LDH (RGO/Zn-Al LDH) film was in situ synthesized on a magnesium alloy substrate by a one-step facile hydrothermal crystallization process. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00529DOI Listing

Mechanically Strong Silica-Silk Fibroin Bioaerogel: A Hybrid Scaffold with Ordered Honeycomb Micromorphology and Multiscale Porosity for Bone Regeneration.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Due to the synergic feature of individual components in hybrid (nano)biomaterials, their application in regenerative medicine has drawn a significant attention. Aiming to address all the current challenges of aerogel as a potent scaffold in bone tissue engineering application, we adopted a novel synthesis approach to synergistically improve the pore size regime and mechanical strength in the aerogel. The 3D aerogel scaffold in this study has been synthesized through a versatile one-pot aqueous based sol-gel hybridization/ assembly of organosilane (tetraethylorthosilicate, TEOS) and silk fibroin (SF) biopolymer followed by unidirectional freeze casting the as-prepared hybrid gel and supercritical drying. Read More

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http://dx.doi.org/10.1021/acsami.9b04283DOI Listing

Magnetotransport Properties of Layered Topological Material ZrTe2 Thin Film.

ACS Nano 2019 Apr 23. Epub 2019 Apr 23.

ZrTe2 is a candidate of topological materials from the layered two-dimensional transition-metal dichalcogenides family, and thus the material may show exotic electrical transport properties and be promising for quantum device applications. In this work, we report the successful growth of layered ZrTe2 thin film by pulsed-laser deposition and the experimental results of its magnetotransport properties. In the presence of a perpendicular magnetic field, the 60 nm-thick ZrTe2 film shows a large magnetoresistance of 3000% at 2 K and 9 T. Read More

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http://dx.doi.org/10.1021/acsnano.9b02196DOI Listing

Co-deposition modification of cation exchange membranes with dopamine and crown ether to achieve high K+ electrodialysis selectivity.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Surface modification has been proven as an effective approach for ion exchange membrane to achieve separation of counter-ions with different valences by altering interfacial construction of membrane to improve ion transfer performance. In this work, we have fabricated a series of novel cation exchange membranes (CEMs) by modifying sulfonated polysulfone (SPSF) membrane via co-deposition of mussel-inspired dopamine (DA) and 4'-aminobenzo-15-crown-5 (ACE), followed by glutaraldehyde cross-linking, aiming at achieving selective separation of specific cations. The as-prepared membranes before and after modification were systematically characterized in terms of their structural, physicochemical, electrochemical and electrodialytic properties. Read More

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http://dx.doi.org/10.1021/acsami.8b21031DOI Listing

Concerns and Treatment Satisfaction in Patients Being Treated With Azelaic Acid Foam for Rosacea

J Drugs Dermatol 2019 Apr;18(4):381-386

Objective: To describe patient characteristics, concerns, side effects, treatment satisfaction, and quality of life (QoL) of rosacea patients currently being treated with monotherapy azelaic acid foam based on patient-reported data. Methods: The study utilized a non-interventional, prospective, observational design. Patients were recruited in the United States and were eligible if the following criteria were met: diagnosed with rosacea by a medical professional, ≥18 years of age, currently receiving monotherapy with azelaic acid foam, and able to provide informed consent. Read More

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Evaluation of Pertussis Toxin Expression in B2 and THIJS Media.

Arch Razi Inst 2019 Mar 1;74(1):59-67. Epub 2019 Mar 1.

Department of Microbiology and Virology, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.

Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi Vaccine and Serum Research Institute is according to bioreactor culture of B. Read More

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http://dx.doi.org/10.22092/ari.2018.110249.1124DOI Listing

Multifunctional Organic Emitters for High-performance and Low-cost Organic Light-emitting Didoes.

Chem Rec 2019 Apr 23. Epub 2019 Apr 23.

Microelectronic R&D Center, School of Mechatronic Engineering and Automation, Shanghai University, 149 Yanchang Road, Shanghai, 200072, P. R. China.

Organic light-emitting diodes (OLEDs) have great potential applications in display and solid-state lighting. Stability, cost and high operational efficiency are key issues governing the future commercial application of OLEDs. In this context, searching for multifunctional emitting materials with acceptable light-emitting and charge-transporting characteristics has gained increasing attention. Read More

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http://dx.doi.org/10.1002/tcr.201900005DOI Listing

Incidence and outcome after first molecular versus overt recurrence in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia included in the ALL Ph08 trial from the Spanish PETHEMA Group.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Hematology, ICO Badalona-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Autonomous University of Barcelona, Badalona, Spain.

Background: Disease recurrence occurs in 20% to 40% of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who are treated with chemotherapy and tyrosine kinase inhibitors (TKIs). In the current study, the authors report the incidence, treatment, and outcome after first disease recurrence in young and older adults treated in the ALL Ph08 trial (ClinicalTrials.gov identifier NCT01491763). Read More

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http://dx.doi.org/10.1002/cncr.32156DOI Listing
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