15,183 results match your criteria Current Obstetrics & Gynaecology[Journal]


Adjunctive Agents for Cervical Preparation in Second Trimester Surgical Abortion.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

Section of Family Planning, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Late second trimester dilation and evacuation is a challenging subset of surgical abortion. Among the reasons for this is the degree of cervical dilation required to safely extricate fetal parts. Cervical dilation is traditionally achieved by placing multiple sets of osmotic dilators over two or more days prior to the evacuation procedure; however, there is interest in shortening cervical preparation time. Read More

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http://link.springer.com/10.1007/s12325-019-00953-2
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http://dx.doi.org/10.1007/s12325-019-00953-2DOI Listing
April 2019
1 Read

Acceptance of apitherapeutic methods in patients consulting general physicians or gynaecologists.

Complement Ther Clin Pract 2019 May 7;35:154-157. Epub 2019 Feb 7.

Department of Hematology and Internal Oncology, University of Jena, Am Klinikum 1, 07747, Jena, Germany.

Background: and purpose: Apitherapists promote the medical use of products from the beehive (bee venom, propolis, pollen, honey, royal jelly, dead bees, apilarnil, wax, wax moths), the use of beehive air or therapeutic sleep on a beehive. However, little is known about how far such treatment options are perceived as acceptable by patients.

Methods: Patients visiting either a family doctor in Kehl or a gynecologist in Weilburg (both in Germany) were asked to rate their knowledge of apitherapy as well as their readiness to use apitherapeutic measures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183074
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http://dx.doi.org/10.1016/j.ctcp.2019.02.005DOI Listing
May 2019
1 Read

Memory T Cells in Pregnancy.

Front Immunol 2019 2;10:625. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Adaptations of the maternal immune response are necessary for pregnancy success. Insufficient immune adaption is associated with pregnancy pathologies such as infertility, recurrent miscarriage, fetal growth restriction, spontaneous preterm birth, and preeclampsia. The maternal immune system is continuously exposed to paternal-fetal antigens; through semen exposure from before pregnancy, through fetal cell exposure in pregnancy, and through microchimerism after pregnancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00625
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http://dx.doi.org/10.3389/fimmu.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455355PMC
April 2019
1 Read

Postpartum Depressive Disorder - Psychosomatic Aspects.

Geburtshilfe Frauenheilkd 2019 Apr 12;79(4):375-381. Epub 2019 Apr 12.

Clinical Institute for Psychosomatic Medicine and Psychotherapy, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Postpartum depression (PPD) is the most common mental illness in mothers following the birth of a child. Since the symptoms of PPD are similar to the normal stress of healthy women following childbirth, it is often difficult for the attending gynaecologist or midwife to diagnose this illness in a timely manner and thus initiate adequate treatment and comprehensive support for the patient. Even if there are options for a screening using evaluated questionnaires and subsequent psychotherapy and/or drug therapy in the treatment of PPD which has proven effective, it is seen that, in most treatment approaches, little consideration is given to the affect-controlled interaction and the bonding behaviour between mother and child. Read More

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http://dx.doi.org/10.1055/a-0759-1981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461464PMC
April 2019
1 Read

Prevalence of health care-associated infections and antimicrobial resistance of the responsible pathogens in Ukraine: Results of a multicenter study (2014-2016).

Am J Infect Control 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy, Topographical Anatomy, and Operative Surgery, Private Higher Educational Establishment "Kyiv Medical University," Kyiv, Ukraine.

Background: The aim of this study was to obtain the first national estimates of the current prevalence and incidence and death of health care-associated infections (HAIs) of all types in acute care hospitals in Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in 17 hospitals. Surveillance case definitions were derived from the Centers for Disease Control and Prevention's National Healthcare Safety Network HAI case definitions. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.007DOI Listing

Effect of preconception low dose aspirin on pregnancy and live birth according to socioeconomic status: A secondary analysis of a randomized clinical trial.

PLoS One 2019 18;14(4):e0200533. Epub 2019 Apr 18.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.

Low socioeconomic status (SES) is associated with adverse pregnancy outcomes and infertility. Low-dose aspirin (LDA) was shown to improve livebirth rates in certain subsets of women, and therefore, may impact pregnancy rates differentially by SES status. Therefore, the aim of the current study was to examine whether daily preconception-initiated LDA affects rates of pregnancy, livebirth, and pregnancy loss differently across strata of socioeconomic status (SES). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200533PLOS
April 2019
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Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review.

Gynecol Oncol Rep 2019 May 27;28:109-115. Epub 2019 Mar 27.

Temple University Hospital, Department of Obstetrics, Gynecology, and Reproductive Sciences, 3401 North Broad Street, Philadelphia, PA 19140, United States of America.

True primary mucinous ovarian carcinomas are rarer than originally thought and their clinical behavior and treatment response are different than more common epithelial ovarian carcinomas. Secondary ovarian neoplasms often mimic the clinical and histological features of mucinous ovarian cancer making their diagnosis, and therefore treatment, more difficult. Misdiagnosis can have a significant impact on both treatment and prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789193003
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http://dx.doi.org/10.1016/j.gore.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453658PMC
May 2019
1 Read

The perceptions of gynecologic oncology fellows on readiness for subspecialty training following OB/GYNRESIDENCY.

Gynecol Oncol Rep 2019 May 20;28:104-108. Epub 2019 Mar 20.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Colorado School of Medicine, Denver, CO, United States of America.

A recent survey of fellowship program directors (PD) within gynecologic oncology (GO) noted concerns regarding the abilities of incoming fellows. The objective of this study was to evaluate the perceptions of current and former fellows in gynecologic oncology of their readiness for fellowship training. A previously used survey was modified and distributed in 2016 to current and former fellows in GO. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451191PMC

Advanced Evolution of Pathogenesis Concepts in Cardiomyopathies.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan.

Cardiomyopathy is a group of heterogeneous cardiac diseases that impair systolic and diastolic function, and can induce chronic heart failure and sudden cardiac death. Cardiomyopathy is prevalent in the general population, with high morbidity and mortality rates, and contributes to nearly 20% of sudden cardiac deaths in younger individuals. Genetic mutations associated with cardiomyopathy play a key role in disease formation, especially the mutation of sarcomere encoding genes and ATP kinase genes, such as titin, lamin A/C, myosin heavy chain 7, and troponin T1. Read More

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https://www.mdpi.com/2077-0383/8/4/520
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http://dx.doi.org/10.3390/jcm8040520DOI Listing
April 2019
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Breastfeeding with HIV: An Evidence-Based Case for New Policy.

J Law Med Ethics 2019 Mar;47(1):152-160

Marielle S. Gross, M.D., M.B.E., is a Hecht-Levi postdoctoral research fellow in the Berman Institute of Bioethics at Johns Hopkins University where she recently completed residency training in Gynecology & Obstetrics. She attended medical school at the University of Florida, and previously completed degrees in Philosophy, Jewish Ethics and Bioethics at Columbia University, the Jewish Theological Seminary, and New York University, respectively. Holly A. Taylor, Ph.D., M.P.H., is a Core Faculty member of the Johns Hopkins Berman Institute of Bioethics and Associate Professor in the Department of Health Policy and Management (HPM), Bloomberg School of Public Health. Dr. Taylor received her B.A. from Stanford University, her M.P.H. from the School of Public Health at the University of Michigan and her Ph.D. in health policy with a concentration in bioethics from the Bloomberg School of Public Health, Johns Hopkins University. Cecilia Tomori, Ph.D., studied biology and education at Swarthmore College and obtained her Ph.D. in Anthropology from the University of Michigan in 2011. She completed a postdoctoral fellowship at Johns Hopkins School of Public Health and served as faculty there between 2013-2017. Jenell S. Coleman, M.D., M.P.H., is associate professor in the Johns Hopkins School of Medicine Department of Gynecology and Obstetrics with a joint appointment in the Department of Medicine and is the medical director of the John's Hopkins Women's Health Center. Dr. Coleman earned her M.D. from the University of Pennsylvania School of Medicine and completed Ob/Gyn residency at the University of California, Los Angeles. She completed a fellowship in reproductive infectious diseases at the University of California, San Francisco and received an M.P.H. from the University of California, Berkeley.

To help eliminate perinatal HIV transmission, the US Department of Health and Human Services recommends against breastfeeding for women living with HIV, regardless of viral load or combined antiretroviral therapy (cART) status. However, cART radically improves HIV prognosis and virtually eliminates perinatal transmission, and breastfeeding's health benefits are well-established. In this setting, pregnancy is increasing among American women with HIV, and a harm reduction approach to those who breastfeed despite extensive counseling is suggested. Read More

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http://dx.doi.org/10.1177/1073110519840495DOI Listing

Female lower urinary tract microbiota do not associate with IC/PBS symptoms: a case-controlled study.

Int Urogynecol J 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology and Immunology, Loyola University Chicago, Health Sciences Division, Stritch School of Medicine, Maywood, IL, 60153, USA.

Introduction And Hypothesis: The current etiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is poorly understood and multifactorial. Recent studies suggest the female urinary microbiota (FUM) contribute to IC/PBS symptoms. This study was designed to determine if the FUM, analyzed using mid-stream voided urine samples, differs between IC/PBS patients and controls. Read More

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http://dx.doi.org/10.1007/s00192-019-03942-9DOI Listing

Role of human epididymis protein 4 (HE4) in detecting recurrence in CA125 negative ovarian cancer patients.

Int J Gynecol Cancer 2019 Apr 16. Epub 2019 Apr 16.

Obstetrics and Gynecology, Gynecology Oncology Unit. Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, Rome, Italy.

Objective: There are no current guidelines regarding evaluation of patients with normal CA125 at initial diagnosis during routine surveillance after completion of treatment. Thus, the purpose of this study was to evaluate the role of human epididymis protein 4 (HE4) in the detection of recurrence in patients with ovarian cancer and a negative CA125 at diagnosis.

Methods: All patients with ovarian cancer with a negative CA125 referred to the Division of Gynecologic Oncology of the University Campus Bio-Medico of Rome were included in the study. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000211DOI Listing

Clinical Features and Management of Women with Borderline Ovarian Tumors in a Single Center in Brazil.

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):176-182. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective:  The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym).

Methods:  The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018.

Results:  A total of 57 women were included, with a mean age of 48. Read More

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http://dx.doi.org/10.1055/s-0039-1683415DOI Listing
March 2019
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Prolactin and breast increase during pregnancy in PCOS - linked to long-term metabolic health?

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

E Vanky, Department of Obstetrics and Gynecology, Department of Women's and Childrens Health, Norwegian University of Technology and Science, Trondheim, United Kingdom of Great Britain and Northern Ireland.

Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (N=239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 participated in the current follow-up study, at mean 8 years after pregnancy. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-
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http://dx.doi.org/10.1530/EJE-19-0002DOI Listing
April 2019
5 Reads

Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis.

PLoS Med 2019 Apr 16;16(4):e1002778. Epub 2019 Apr 16.

Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.

Background: Despite the relative ease with which breech presentation can be identified through ultrasound screening, the assessment of foetal presentation at term is often based on clinical examination only. Due to limitations in this approach, many women present in labour with an undiagnosed breech presentation, with increased risk of foetal morbidity and mortality. This study sought to determine the cost effectiveness of universal ultrasound scanning for breech presentation near term (36 weeks of gestational age [wkGA]) in nulliparous women. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002778DOI Listing

Downregulation of microRNA-425-5p suppresses cervical cancer tumorigenesis by targeting AIFM1.

Exp Ther Med 2019 May 18;17(5):4032-4038. Epub 2019 Mar 18.

Department of Gynecology and Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei 050011, P.R. China.

Although microRNA-425-5p (miR-425-5p) has been previously revealed to be upregulated in cervical cancer, the cellular function of miR-425-5p in cervical cancer remains unknown. The aim of the current study was to investigate the cellular function of miR-425-5p and its underlying mechanism in cervical cancer. Reverse transcription-quantitative polymerase chain reaction was used to measure miR-425-5p expression in several cervical cancer cell lines. Read More

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http://dx.doi.org/10.3892/etm.2019.7408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447898PMC

Determination of the chemical components and phospholipids of velvet antler using UPLC/QTOF-MS coupled with UNIFI software.

Exp Ther Med 2019 May 12;17(5):3789-3799. Epub 2019 Mar 12.

Department of Natural Medicinal Chemistry, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.

Velvet antler, which exhibits immune and growth enhancing effects, is commonly used in a variety of Asian health care products, but its complex components remain unknown. The current study analyzed extracts using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry in the MS mode. Automated detection and data filtering were performed using UNIFI software and peaks were compared with a proprietary scientific library (Traditional Medicine Library; TML). Read More

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http://dx.doi.org/10.3892/etm.2019.7372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447902PMC

Effects of RNAi-induced Skp2 inhibition on cell cycle, apoptosis and proliferation of endometrial carcinoma cells.

Exp Ther Med 2019 May 13;17(5):3441-3450. Epub 2019 Mar 13.

Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

The aim of the current study was to investigate the underlying mechanism of S-phase kinase associated protein 2 (Skp2) gene inhibition by lentivirus-mediated RNA interference (RNAi) on the cell cycle, apoptosis and proliferation of endometrial carcinoma HEC-1-A cells. A lentivirus shRNA vector targeting Skp2 was constructed and transfected into HEC-1-A cells. HEC-1-A cells transfected with a scramble sequence were used as negative controls. Read More

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http://dx.doi.org/10.3892/etm.2019.7392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447788PMC
May 2019
1 Read

IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Placenta Lab, Department of Obstetrics, Jena University Hospital, 07740 Jena, Germany.

The IL-36 subfamily of cytokines has been recently described as part of the IL-1 superfamily. It comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), their receptor (IL-36R), and one antagonist (IL-36Ra). Although expressed in a variety of cells, the biological relevance of IL-36 cytokines is most evident in the communication between epithelial cells, dendritic cells, and neutrophils, which constitute the common triad responsible for the initiation, maintenance, and expansion of inflammation. Read More

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http://dx.doi.org/10.3390/ijms20071649DOI Listing
April 2019
1 Read

Embryology, Anatomy, and Radiology of Cervical Cysts and Cleft Lip/Palate: A Team-Based Learning Module for Medical Students.

MedEdPORTAL 2016 Oct 13;12:10484. Epub 2016 Oct 13.

Professor, Department of Radiology and the Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center Dallas.

Introduction: Current medical education promotes enhanced integration of various disciplines and early exposure to clinically relevant topics. Against this background, we have developed a team-based learning (TBL) module for medical students in the preclerkship period that integrates embryology, anatomy, and radiology of the head and neck region.

Methods: The module, which includes prereading assignments, readiness assurance tests, and an application exercise, focuses on the development of the head and neck region. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440433PMC
October 2016

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.

J Vis Exp 2019 Mar 29(145). Epub 2019 Mar 29.

Viral Vector Core, Duke University Medical Center;

The use of hiPSC-derived cells represents a valuable approach to study human neurodegenerative diseases. Here, we describe an optimized protocol for the differentiation of hiPSCs derived from a patient with the triplication of the alpha-synuclein gene (SNCA) locus into Parkinson's disease (PD)-relevant dopaminergic neuronal populations. Accumulating evidence has shown that high levels of SNCA are causative for the development of PD. Read More

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http://dx.doi.org/10.3791/59241DOI Listing
March 2019
1 Read

Hypothyroidism in Pregnancy.

Authors:
Scott A Sullivan

Clin Obstet Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Hypothyroidism in pregnancy is defined as the presence of an elevated thyroid stimulating hormone during gestation, affecting 2% to 3% of the population. Overt hypothyroidism is diagnosed by a decreased FT4, while patients with a normal FT4 are considered to have subclinical disease. Poorly controlled disease is associated with both pregnancy complications and developmental delays in the offspring. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000432DOI Listing
April 2019
2 Reads

Epidural test dose in obstetric patients: should we still use it?

Curr Opin Anaesthesiol 2019 Apr 9. Epub 2019 Apr 9.

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.

Purpose Of Review: As the application of a test dose after epidural catheter insertion in obstetrics has recurrently been associated with serious adverse events affecting both maternal and foetal outcomes, the question whether to test or not remains a controversial issue.

Recent Findings: Present guidelines do not provide clear recommendations in this regard and several recent surveys indicate a heterogeneity in clinical routine.

Summary: Physiological alterations during pregnancy and labour restrict the use and also the validity of traditional test agents. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000721DOI Listing
April 2019
7 Reads

Vaginal dryness: individualised patient profiles, risks and mitigating measures.

EPMA J 2019 Mar 2;10(1):73-79. Epub 2019 Mar 2.

9Radiological clinic, UKB, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

Vaginal dryness (VD) affects both pre- and postmenopausal women at any age. Since the hormonal regulation changes during the climacteric period are considered as being the main course of the VD, affected women prefer not to talk about the problem. However, the problem does exist, and unfortunately if any, relatively minor group in the population possesses the health literacy at sufficient level to understand that VD is a suboptimal health condition which carries a multi-factorial character. Read More

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http://link.springer.com/10.1007/s13167-019-00164-3
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http://dx.doi.org/10.1007/s13167-019-00164-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459457PMC
March 2019
6 Reads

Cord Blood Banking: Antenatal Care Provider's Roles and Responsibilities.

Stem Cells Int 2019 7;2019:3598404. Epub 2019 Mar 7.

Manipal Academy of Higher Education, Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal 576104, India.

Background: Umbilical Cord Blood (UCB) banking done either for private storage or for donation to public cord blood banks involves active participation of obstetricians. Counseling the expectant parents, providing them with unbiased and balanced information, and collecting the UCB with diligence confer a lot of social as well as moral responsibility upon obstetricians. This makes it even more important that the obstetricians in current practice stay well-informed and updated with UCB collection and its storage guidelines. Read More

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http://dx.doi.org/10.1155/2019/3598404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431514PMC
March 2019
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The Tumor Immune Contexture of Prostate Cancer.

Front Immunol 2019 28;10:603. Epub 2019 Mar 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

One in seven men in North America is expected to be diagnosed with prostate cancer (PCa) during their lifetime (1, 2). While a wide range of treatment options including surgery, radiation, androgen deprivation and chemotherapy have been in practice for the last few decades, there are limited treatment options for metastatic and treatment resistant disease. Immunotherapy targeting T-cell associated immune checkpoints such as CTLA-4, PD-L1, and PD-1 have not yet proven to be efficacious in PCa. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00603
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http://dx.doi.org/10.3389/fimmu.2019.00603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447686PMC
March 2019
2 Reads

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, the First Clinical Medical College of Jinan University, Guangzhou, Guangdong 510632, China.

Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0004DOI Listing
April 2019
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DNA Methylation Studies of Depression with Onset in the Peripartum: A Critical Systematic Review.

Neurosci Biobehav Rev 2019 Apr 11. Epub 2019 Apr 11.

School of Nursing, Virginia Commonwealth University, Richmond VA 23298, USA. Electronic address:

Objective: Major depression with peripartum onset (MDP) has been associated with multiple adverse offspring health outcomes. The biological mechanisms underlying this relationship remain unclear, but DNA methylation (DNAm) represents a plausible mechanism for mediating MDP exposures and changes in offspring development, behavior, and health. Advances in DNAm research necessitate reevaluating the MDP-DNAm literature to determine how well past studies conform with current best practices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497634183077
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http://dx.doi.org/10.1016/j.neubiorev.2019.04.005DOI Listing
April 2019
2 Reads

N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.

Cell Syst 2019 Apr 3. Epub 2019 Apr 3.

University of Toronto, Department of Medical Biophysics, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address:

High-grade serous ovarian carcinoma (HGSC) is the most common and lethal subtype of gynecologic malignancy in women. The current standard of treatment combines cytoreductive surgery and chemotherapy. Despite the efficacy of initial treatment, most patients develop cancer recurrence, and 70% of patients die within 5 years of initial diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193008
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http://dx.doi.org/10.1016/j.cels.2019.03.011DOI Listing
April 2019
2 Reads

Association between FOXP3 regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts.

Reprod Biomed Online 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

Research Question: Is there any relationship between numbers of FOXP3 regulatory T-cells (Treg) and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts?

Design: Retrospective and prospective case-controlled cohort study. Peritoneal lesions were collected from 27 women with ovarian endometrioma and 25 women with dermoid cysts. Peritoneal fluid was collected from 36 women with ovarian endometrioma and 42 women with dermoid cysts. Read More

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http://dx.doi.org/10.1016/j.rbmo.2019.01.011DOI Listing
January 2019
1 Read

Research of the impact of urinary infection teaching methods on the learning process.

Actas Urol Esp 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Urología, Hospital Nacional de Parapléjicos de Toledo, Toledo, España.

Introduction: The classical teaching methodology was based on passive transmission-based learning. The model has changed towards an orientation based on student-centred learning.

Objective: The objective of the study has been to evaluate the students' perception when learning about urinary tract infections, and their perspective about the teaching imparted on this pathology in the various subjects that include ITU in their syllabus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02104806193000
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http://dx.doi.org/10.1016/j.acuro.2018.11.001DOI Listing
April 2019
1 Read

Sentinel lymph node biopsies in endometrial cancer - practice patterns among Gynecologic Oncologists in the United States.

J Minim Invasive Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University School of Medicine. Electronic address:

Study Objective: To evaluate practice patterns among gynecologic oncologists with regards to sentinel lymph node injection and biopsy in endometrial cancer.

Design: Observational study with no control group.

Setting And Patients: Active members of the Society of Gynecologic Oncology. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.006DOI Listing
April 2019
1.575 Impact Factor

The pleiotropic effect of rs7903146 on type 2 diabetes and ischemic stroke: a family-based study in a Chinese population.

J Thromb Thrombolysis 2019 Apr 12. Epub 2019 Apr 12.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

The rs7903146, an established genetic variant susceptible to type 2 diabetes (T2D), is also reported to be related to ischemic stroke (IS), though conflicting. Furthermore, it remained unknown whether the genetic association with stroke is independent of T2D. In the current study, 1603 individuals across 986 families were included. Read More

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http://dx.doi.org/10.1007/s11239-019-01855-4DOI Listing

Cervical cancer screening among women living with HIV: a cross-sectional study using the baseline questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS).

CMAJ Open 2019 Apr-Jun;7(2):E217-E226. Epub 2019 Apr 12.

Chronic Viral Illness Service (de Pokomandy, Bakombo, Proulx-Boucher), McGill University Health Centre; Department of Family Medicine (de Pokomandy, O'Brien), McGill University, Montréal, Que.; Department of Family and Community Medicine (Burchell), St. Michael's Hospital; Department of Family and Community Medicine (Burchell), University of Toronto, Toronto, Ont.; Faculty of Health Sciences (Salters, Kaida), Simon Fraser University, Burnaby, BC; BC Centre for Excellence in HIV/AIDS (Salters, Ding, Kaida), Vancouver, BC; Department of Obstetrics and Gynecology (Boucoiran), Hôpital Sainte-Justine and Université de Montréal, Montréal, Que.; Oak Tree Clinic (Pick), BC Women's Hospital; Department of Family Practice (Ogilvie), School of Population and Public Health, University of British Columbia, Vancouver, BC; Women's College Research Institute (Loutfy), Women's College Hospital; Faculty of Medicine (Loutfy), University of Toronto, Toronto, Ont.

Background: Cisgender women with HIV experience an elevated risk of cervical cancer compared with HIV-negative women, but this cancer can be prevented through regular cervical cancer screening. Our study objective was to measure adherence to current national cervical cancer screening guidelines among women with HIV in 3 Canadian provinces and identify factors associated with delays.

Methods: We conducted a cross-sectional study using the baseline questionnaire of the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS). Read More

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http://dx.doi.org/10.9778/cmajo.20180151DOI Listing

Making cesarean delivery SAFE in low- and middle-income countries.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.

Cesarean birth (CB) rates are rising, globally. The global burden of CB is having a mixed effect on pregnancy outcomes and requires significant clinical and economic resources. The context of CB care in low- and middle-income countries is further complicated by barriers to facility-based care itself, followed by issues with quality and delivery of care in these resource-limited settings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193004
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http://dx.doi.org/10.1053/j.semperi.2019.03.015DOI Listing
March 2019
2 Reads

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.

PLoS One 2019 12;14(4):e0215326. Epub 2019 Apr 12.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215326PLOS
April 2019
2 Reads

Outcome of fetuses with lower urinary tract obstruction and normal amniotic fluid volume in the second trimester of pregnancy: a single center experience.

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Baylor College of Medicine, and Texas Children's Fetal Center, Houston, Texas, USA.

Objective: Congenital lower urinary tract obstruction (LUTO) is a rare condition with high perinatal mortality and morbidity when associated with severe oligohydramnios or anhydramnios in the second trimester of pregnancy. Severe pulmonary hypoplasia and end-stage renal disease are the underlying causes of poor neonatal outcomes in these cases. However, little is known about the subset of fetal LUTO with a normal amount of amniotic fluid at mid-gestation. Read More

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http://dx.doi.org/10.1002/uog.20288DOI Listing
April 2019
2 Reads

Mother-infant bonding is not associated with feeding type: a community study sample.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):125. Epub 2019 Apr 11.

Obstetrics & Gynecology, Edith Wolfson Medical Center, Ha-Lochamim 62, Holon, Israel.

Background: Bonding refers to emotions and cognitions towards one's infant. Breastfeeding is believed to facilitate bonding, yet only a handful of studies have empirically tested this assertion. This study aimed to confirm whether a positive association between breastfeeding and bonding exists and whether breastfeeding may be protective against the negative consequences of mood and sleep disturbances on bonding. Read More

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https://bmcpregnancychildbirth.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12884-019-2264-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458683PMC
April 2019
4 Reads

Postpartum endometritis and obstetrical sepsis associated with Eggerthella lenta. Case report and review of the literature.

J Matern Fetal Neonatal Med 2019 Apr 12:1-5. Epub 2019 Apr 12.

f International Cooperation Department , National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Health of the Russian Federation , Moscow , Russia.

Sepsis, associated with Eggerthella lenta is rarely reported, despite current possibilities for microorganisms isolation and identification. About 100 cases of bacteriemia associated with this pathogen have been reported so far. Postpartum infectious complications are mostly associated with bacterial inhabitants of gastrointestinal tract and vagina, including obligatory anaerobes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1602602DOI Listing
April 2019
1 Read

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.

Neonatology 2019 Apr 11;115(4):432-451. Epub 2019 Apr 11.

Department of Child Health, Queen's University Belfast and Royal Maternity Hospital, Belfast, United Kingdom.

As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update of "European Guidelines for the Management of RDS" by a European panel of experienced neonatologists and an expert perinatal obstetrician based on available literature up to the end of 2018. Optimising outcome for babies with RDS includes prediction of risk of preterm delivery, need for appropriate maternal transfer to a perinatal centre and timely use of antenatal steroids. Read More

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https://www.karger.com/Article/FullText/499361
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http://dx.doi.org/10.1159/000499361DOI Listing
April 2019
33 Reads

The Effect Of Sex And Menopause On Carotid Intima Media Thickness and Pulse Wave Velocity In Morbid Obesity.

Eur J Clin Invest 2019 Apr 11:e13118. Epub 2019 Apr 11.

Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

Background: Women are relatively protected from cardiovascular disease compared to men. Since morbid obesity is an independent risk factor for cardiovascular disease, the current study investigated whether the association between sex and cardiovascular risk factors and outcomes can be demonstrated in subjects suffering from morbid obesity.

Materials And Methods: 200 subjects enrolled in a study on cardiovascular risk factors in morbid obesity underwent extensive laboratory screening, carotid intima media thickness (cIMT) and pulse wave velocity (PWV) measurements. Read More

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http://dx.doi.org/10.1111/eci.13118DOI Listing
April 2019
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Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.

Front Endocrinol (Lausanne) 2019 26;10:179. Epub 2019 Mar 26.

Division of Obstetrics and Gynecology, Department of Women-Children-Teenagers, University Hospitals Geneva, Geneva, Switzerland.

The environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate the growth of the fetus and its metabolism during pregnancy by controlling the supply of nutrients crossing the placenta. In addition to fetal synthesis, hormones regulating fetal growth are also expressed and regulated in the placenta, and they play a key role in the vulnerability of the developing brain and its maturation. Read More

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http://dx.doi.org/10.3389/fendo.2019.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443724PMC

International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation.

Br J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Women's College Research Institute, Toronto, ON, Canada.

Background: Women with a BRCA1 or BRCA2 mutation face high risks of breast and ovarian cancer. In the current study, we report on uptake of cancer screening and risk-reduction options in a cohort of BRCA mutation carriers from ten countries over two time periods (1995 to 2008 and 2009 to 2017).

Methods: Eligible subjects were identified from an international database of female BRCA mutation carriers and included women from 59 centres from ten countries. Read More

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http://dx.doi.org/10.1038/s41416-019-0446-1DOI Listing

Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study.

J Clin Med 2019 04 9;8(4). Epub 2019 Apr 9.

Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their pregnancy (Group C), 123 women with vaginal bleeding but without PA (Group D), and 46 healthy pregnant women who had undergone a control laboratory evaluation in the second/third trimester for history of previous cytomegalovirus (additional control group) were included. Hemoglobin, leukocytes, thrombocytes, C-reactive protein (CRP), and fibrinogen were obtained within 48 hours before C-section and/or at the time of bleeding onset. Read More

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http://dx.doi.org/10.3390/jcm8040482DOI Listing
April 2019
1 Read

Mining Featured Biomarkers Linked with Epithelial Ovarian CancerBased on Bioinformatics.

Diagnostics (Basel) 2019 Apr 9;9(2). Epub 2019 Apr 9.

Biostatistics and Bioinformatics,Chanabasava Nilaya, Bharthinagar,Dharwad, Karanataka 580001, India.

Epithelial ovarian cancer (EOC) is the18th most common cancer worldwide and the 8th most common in women. The aim of this study was to diagnose the potential importance of, as well as novel genes linked with, EOC and to provide valid biological information for further research. The gene expression profiles of E-MTAB-3706 which contained four high-grade ovarian epithelial cancer samples, four normal fallopian tube samples and four normal ovarian epithelium samples were downloaded from the ArrayExpress database. Read More

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http://dx.doi.org/10.3390/diagnostics9020039DOI Listing
April 2019
3 Reads

Artificial intelligence in reproductive medicine.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Liao, Department of Obstetrics and Gynecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Artificial intelligence (AI) has experienced rapid growth over the past few years, moving from the experimental to the implementation phase in various fields, including medicine. Advances in learning algorithms and theories, the availability of large datasets, and improvements in computing power have contributed to breakthroughs in current AI applications. Machine learning (ML), a subset of AI, allows computers to detect patterns from large complex datasets automatically and uses these patterns to make predictions. Read More

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http://dx.doi.org/10.1530/REP-18-0523DOI Listing
April 2019
3 Reads

Accuracy of Micro-Computed Tomography in Post-mortem Evaluation of Fetal Congenital Heart Disease. Comparison Between Post-mortem Micro-CT and Conventional Autopsy.

Front Pediatr 2019 22;7:92. Epub 2019 Mar 22.

Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.

Early prenatal diagnosis of congenital heart disease is feasible. Conventional autopsy is the current gold standard method for post-mortem confirmation. Radiologic techniques alternative to conventional autopsy, such as post-mortem micro-computed tomography, have been proposed in case of limited diagnostic accuracy (i. Read More

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http://dx.doi.org/10.3389/fped.2019.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440368PMC
March 2019
1 Read

Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury.

Front Physiol 2019 22;10:283. Epub 2019 Mar 22.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Read More

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http://dx.doi.org/10.3389/fphys.2019.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440382PMC
March 2019
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Photonic Molecularly Imprinted Polymer Film for the Detection of Testosterone in Aqueous Samples.

Polymers (Basel) 2018 Mar 22;10(4). Epub 2018 Mar 22.

Department of Civil and Environmental Engineering, University of Missouri, Columbia, MO 65211, USA.

The detection of testosterone in aqueous solutions is a difficult task due to the low concentration levels that are relevant in environmental and physiological samples. Current analytical methods are expensive and/or complex. To address this issue, we fabricated a molecularly imprinted polymer (MIP) photonic film for the detection of testosterone in water. Read More

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http://dx.doi.org/10.3390/polym10040349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415058PMC

Combining conventional therapy with immunotherapy: A risky business?

Eur J Cancer 2019 Apr 6;113:41-44. Epub 2019 Apr 6.

Department of Gynaecology and Obstetrics, Leuven Cancer Institute, UZ Leuven, Leuven, Belgium; Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven, Belgium; Department of Oncology, Laboratory of Gynecologic Oncology, KU Leuven, Leuven, Belgium. Electronic address:

Because of the failure of immunotherapy as single agent in a number of cancers, current clinical trials are focusing on combining immunotherapy with other therapies. The most frequently chosen combination for immunotherapy is chemotherapy. However, almost no preclinical data on this combination is available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.02.014DOI Listing