14,893 results match your criteria Current Obstetrics & Gynaecology[Journal]


Endometriosis-associated ovarian cancer: What have we learned so far?

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan; Deparment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan; Deparment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan; Deparment of Nursing, Asia University, Taichung, Taiwan. Electronic address:

Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.016DOI Listing
February 2019
1 Read

Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):719-722

Department of Obstetrics and Gynecology, Infertility Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques.

Objective: Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject.

Materials And Methods: In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled. Read More

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November 2018

Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm SAMBA Study.

Biomed Res Int 2019 16;2019:5476350. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), School of Medical Sciences, Campinas, SP, Brazil.

Background: Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Read More

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http://dx.doi.org/10.1155/2019/5476350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354138PMC
January 2019

MicroRNA-505 suppresses gastric cancer cell proliferation and invasion by directly targeting Polo-like kinase-1.

Onco Targets Ther 2019 24;12:795-803. Epub 2019 Jan 24.

Department of Oncology, Zhenjiang Hospital of Traditional Chinese and Western Medicine, Zhenjiang, Jiangsu 212001, People's Republic of China,

Purpose: The expression of microRNA-505 (miR-505) has been investigated in various cancers; however, its effect and mechanism in relation to gastric cancer (GC) are yet to be determined. Thus, the current evaluation aimed to examine the expression and potential role of miR-505 in GC.

Materials And Methods: Quantitative real-time PCR was carried out to analyze miR-505 expression in GC cells and tissues. Read More

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http://dx.doi.org/10.2147/OTT.S189521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352865PMC
January 2019

Uterine fibroids: an update on current and emerging medical treatment options.

Ther Clin Risk Manag 2019 23;15:157-178. Epub 2019 Jan 23.

Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy,

Uterine fibroids are the most common gynecological disorder, classically requiring surgery when symptomatic. Although attempts at finding a nonsurgical cure date back to centuries, it is only around the middle of the last century that serious attempts at a medical treatment were carried out. Initially, both progestins and estrogen-progestin combinations have been utilized, although proof of their usefulness is lacking. Read More

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http://dx.doi.org/10.2147/TCRM.S147318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350833PMC
January 2019

By regulating miR-182-5p/BCL10/CYCS, sufentanil reduces the apoptosis of umbilical cord mesenchymal stem cells caused by ropivacaine.

Biosci Trends 2019 Feb 17. Epub 2019 Feb 17.

Obstetrics and Gynecology Hospital of Fudan University.

Sufentanil is a type of opioid analgesic and is usually used to facilitate painless labor in combination with the local anesthetic ropivacaine. One aim of the current study was to investigate the effects of sufentanil and ropivacaine on umbilical cord mesenchymal stem cells (UCMSCs). A second aim of this study was to determine whether sufentanil attenuated the cytotoxicity of ropivacaine in vitro. Read More

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http://dx.doi.org/10.5582/bst.2018.01291DOI Listing
February 2019

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.

Am J Hum Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

SPONASTRIME dysplasia is an autosomal-recessive spondyloepimetaphyseal dysplasia characterized by spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disproportionate short stature. Scoliosis, coxa vara, childhood cataracts, short dental roots, and hypogammaglobulinemia have also been reported in this disorder. Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic variants in a specific gene have not been discovered in individuals with SPONASTRIME dysplasia. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.01.007DOI Listing
February 2019

Human Papillomavirus Vaccine Interventions in the U.S.: A Systematic Review and Meta-analysis.

Am J Prev Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Preventive Medicine and Community Health, University of Texas Medical Branch at Galveston, Galveston, Texas.

Context: Despite current recommendations, human papillomavirus vaccine uptake remains low. A systematic review and meta-analysis assessed the effectiveness of interventions targeting human papillomavirus vaccine initiation and completion among children, adolescents, and young adults aged 9-26 years.

Evidence Acquisition: Three electronic databases (CINAHL, OVID, and Web of Science) were searched for articles published in English peer-reviewed journals between January 2006 and January 2017 of U. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.033DOI Listing
February 2019

Current treatments for female primary stress urinary incontinence.

Climacteric 2019 Feb 18:1-7. Epub 2019 Feb 18.

a Department of Obstetrics and Gynaecology, Helsinki University Hospital , Helsinki University , Helsinki , Finland.

Stress urinary incontinence (SUI) affects millions of women worldwide. Pelvic floor muscle training is the first-line treatment for SUI, and if this fails, midurethral sling surgery has become the gold-standard treatment. More recently, complications from midurethral mesh slings, particularly chronic pain and dyspareunia, have become a major concern. Read More

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http://dx.doi.org/10.1080/13697137.2019.1568404DOI Listing
February 2019
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Fertility preservation in Turkey: a global look for nationwide strategy development

J Turk Ger Gynecol Assoc 2019 Feb 18. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Acıbadem University Faculty of Medicine, İstanbul, Turkey

Objective: As the reproductive technology advanced along with the improved outcome in cancer treatment demands implementing new fertility preservation. Developing algorithms on fertility preservation requires tailoring for each society. Here authors attempts to modify the current medical literature on fertility preservation for Turkish population. Read More

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http://dx.doi.org/10.4274/jtgga.2018.0116DOI Listing
February 2019

Localized high grade endometrial stromal sarcoma and localized undifferentiated uterine sarcoma: a retrospective series of the French Sarcoma Group.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Oncology, CHU Timone, AP-HM, Marseille, France.

Objective: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear.

Methods: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000064DOI Listing
February 2019

Anesthesia for non-obstetric surgery during pregnancy in a tertiary referral center: a 16-year retrospective, matched case-control, cohort study.

Int J Obstet Anesth 2019 Jan 12. Epub 2019 Jan 12.

Department of Anesthesiology, University Hospitals of the KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

Introduction: This retrospective, matched case-control cohort study describes the incidence, indications, anesthesia techniques and outcomes of pregnancies complicated by surgery in a single tertiary-referral hospital.

Methods: Retrospective review of the hospital records of 171 patients who had non-obstetric surgery in the current pregnancy, between 2001 and 2016. Pregnancy outcomes of these women were firstly compared with all contemporary non-exposed patients (n=35 411), and secondly with 684 non-exposed control patients, matched for age, time of delivery and parity. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.006DOI Listing
January 2019

Primary and secondary prevention of preterm birth: a review of systematic reviews and ongoing randomized controlled trials.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Dalhousie University, Halifax Nova Scotia, Canada.

Background: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality. Interventions aimed at preventing PTB can be classified as primary, secondary, or tertiary prevention.

Objective: To conduct a review of systematic reviews on the effectiveness and safety of primary and secondary preterm birth prevention interventions. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.022DOI Listing
January 2019

Emergency Department Patients are Receptive to Prayer-Based Interventions to Reduce Alcohol Use.

J Relig Health 2019 Feb 15. Epub 2019 Feb 15.

Center for Policy & Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR, USA.

Previous studies show that elements of spirituality, including prayer and religious services, may contribute to reductions in harmful alcohol use. The objective of this study was to assess the acceptability of prayer as a component of emergency department (ED) interventions for risky alcohol use. A 12-question multiple-choice questionnaire was developed, piloted, and refined by the study team. Read More

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http://dx.doi.org/10.1007/s10943-019-00779-wDOI Listing
February 2019

Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center.

BMC Cancer 2019 Feb 15;19(1):154. Epub 2019 Feb 15.

Department of preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

Background: The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, what are the levels of the women's awareness /behavior toward available screening tools?

Methods: An individual cancer risk assessment questionnaire has been developed in the Department of Preventive Oncology, which questions the medical history, health behaviors and cancer awareness, as well as their behavior toward available cancer screening tools.

Results: The mean age of the study population was 45. Read More

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http://dx.doi.org/10.1186/s12885-019-5350-9DOI Listing
February 2019

Current Progress in Uterus Transplantation Research in Asia.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. Read More

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http://dx.doi.org/10.3390/jcm8020245DOI Listing
February 2019
1 Read

Cholecystectomy During the Third Trimester of Pregnancy: Proceed or Delay?

J Am Coll Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Surgery, Massachusetts General Hospital, Boston, MA.

Background: Current guidelines suggest that cholecystectomy during the third trimester of pregnancy is safe for both the women and the fetus. However, no population-based study has examined this issue. The aim of this analysis was to compare the results of cholecystectomy during the third trimester of pregnancy with outcomes in women operated on in the early postpartum period in a large population. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.024DOI Listing
January 2019

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Womens Midlife Health 2018 16;4. Epub 2018 Mar 16.

6Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 USA.

Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.

Methods: In a healthy, community-based sub-sample ( = 350) of reproductive age participants in the OVA Study (2006-2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Read More

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http://dx.doi.org/10.1186/s40695-018-0033-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297989PMC

Ultrasound-guided biodegradable subacromial spacer implantation in a patient with massive irreparable rotator cuff tears.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 8;14(1):145-148. Epub 2018 Aug 8.

National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

The aim of this manuscript is to present a modification of the current arthroscopic implantation technique of a biodegradable subacromial spacer. This modified ultrasound-guided technique was intended to maximally reduce the invasiveness of the procedure. The ultrasound technique was used to measure the subacromial space for an optimal fit and to verify subacromial spacer placement in the sagittal and frontal planes. Read More

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http://dx.doi.org/10.5114/wiitm.2018.77555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372862PMC
January 2019

Genitourinary syndrome of menopause - is the problem solved? State of the art 2018.

Prz Menopauzalny 2018 Dec 31;17(4):168-174. Epub 2018 Dec 31.

1 Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland.

Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. Read More

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http://dx.doi.org/10.5114/pm.2018.81741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372854PMC
December 2018

Uterine artery embolization in the treatment of symptomatic fibroids - state of the art 2018.

Authors:
Anna Stępniak

Prz Menopauzalny 2018 Dec 31;17(4):141-143. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Uterine fibroids are considered to be the most common benign tumours in females. The vast majority of these tumours are incidental findings and do not require any treatment. Symptomatic fibroids, with ailments such as abnormal uterine bleeding, dysmenorrhoea, pelvic pain, impaired urination, bowel dysfunction, infertility, and recurrent pregnancy loss, are indicated for medical treatment. Read More

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http://dx.doi.org/10.5114/pm.2018.81733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372851PMC
December 2018

Dissecting the current caesarean section rate in Shanghai, China.

Sci Rep 2019 Feb 14;9(1):2080. Epub 2019 Feb 14.

School of Public Health, Guilin Medical University, Guilin, Guangxi, 541004, China.

The high caesarean section (CS) rate has been of great public concern around the world. Yet, large-scale studies of dissecting such a high CS rate are few in the Chinese population. We carried out a cross-sectional survey randomly selecting 10,855 births from 20 hospitals in Shanghai from January to June, 2016. Read More

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http://dx.doi.org/10.1038/s41598-019-38606-7DOI Listing
February 2019

Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing.

J Craniomaxillofac Surg 2019 Jan 22. Epub 2019 Jan 22.

Dicle University, Diyarbakır Technical Sciences Vocational School, Diyarbakır, Turkey.

Aim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model.

Material And Methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.01.023DOI Listing
January 2019

Vaccination against HPV and view of new possibilities.

Ceska Gynekol 2018 ;83(3):218-225

Objective: Overview of available information on current vaccination options against HPV and possibilities for further development.

Design: Review article.

Settings: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava; Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

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January 2018
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Planned home births in the Czech Republic, 2018.

Ceska Gynekol 2018 ;83(3):204-211

Study Aim: A summary of the current situation regarding issues of planned home births in the Czech Republic.

Type Of Study: Review and summarization. Affiliations: Department of Obstetrics and Gynecology of the Liberec regional hospital, and the Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital in Prague. Read More

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January 2018

Effectiveness and safety of fluoxetine for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2019 Feb;98(7):e14481

Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men's self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men's health has gained more and more attention. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902150-0004
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http://dx.doi.org/10.1097/MD.0000000000014481DOI Listing
February 2019
3 Reads

Expanded genetic carrier screening in clinical practice: a current survey of patient impressions and attitudes.

J Assist Reprod Genet 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University, 128 Apple Street, Suite 3800 Weber CHE, Dayton, OH, 45409, USA.

Purpose: Expanded genetic carrier screening (ECS) is an important part of gynecological practice and preconception planning. We evaluated the awareness and attitudes among women regarding ECS and factors that may influence decision-making in a family planning context.

Methods: A 32-question survey in an academic university practice was given to 521 women who were either currently pregnant (n = 108), undergoing gynecologic care who were considering future fertility (n = 308), and considering or receiving fertility treatment (n = 105). Read More

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http://dx.doi.org/10.1007/s10815-019-01414-zDOI Listing
February 2019
2 Reads

High Ki-67 expression is significantly associated with poor prognosis of ovarian cancer patients: evidence from a meta-analysis.

Arch Gynecol Obstet 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, The Affiliated Chencun Hospital of Shunde Hospital of Southern Medical University, Shunde, 528300, Guangdong, People's Republic of China.

Objective: The prognostic significance of Ki-67 expression in patients with ovarian cancer was controversial in various studies. Therefore, we carried out a meta-analysis to determine the prognostic significance of Ki-67 in ovarian cancer patients.

Methods: We searched PubMed, Cochrane Library, EMBASE, Web of Knowledge, China National Knowledge Infrastructure database and WanFang digital database for eligible studies from January 1, 1990 to June 1, 2017. Read More

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http://dx.doi.org/10.1007/s00404-019-05082-3DOI Listing
February 2019

Comparative Assessment of Economic Burden of Disease in Relation to Out of Pocket Expenditure.

Front Public Health 2019 29;7. Epub 2019 Jan 29.

School of Humanities and Social Sciences, Indian Institute of Technology Mandi, Mandi, India.

The economic costs associated with morbidity pose a great financial risk on the population. Household's over-dependence on out-of-pocket (OOP) health expenditure and their inability to cope up with the economic costs associated with illness often push them into poverty. The current paper aims to measure the economic burden and resultant impoverishment associated with OOP health expenditure for a diverse set of ailments in India. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362399PMC
January 2019

Unresolved Trauma and Reorganization in Mothers: Attachment and Neuroscience Perspectives.

Front Psychol 2019 30;10:110. Epub 2019 Jan 30.

Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.

The onset of motherhood is characterized by significant psychological and neurobiological changes. These changes equip the mother to care for her new child. Although rewarding, motherhood is also an inherently stressful period, more so for mothers with unresolved trauma. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363675PMC
January 2019

Microvesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.

Mol Cell Proteomics 2019 Feb 13. Epub 2019 Feb 13.

Sheba Cancer Research Center, Chaim Sheba Medical Center, Israel.

High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tubal lavage (UtL), may identify localized lesions better than systemic approaches of serum/plasma analysis. Read More

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http://dx.doi.org/10.1074/mcp.RA119.001362DOI Listing
February 2019

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies.

Curr Stem Cell Res Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Gynaecology and Obstetrics, Geneva University Hospital, 30, bvd de la Cluse, 1205, Genève. Switzerland.

Asherman's Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman's syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman's Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. Read More

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http://dx.doi.org/10.2174/1574888X14666190213100528DOI Listing
February 2019

Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study.

J Matern Fetal Neonatal Med 2019 Feb 13:1-171. Epub 2019 Feb 13.

a Obstetrics and Gynecology Department , Graduate Entry Medical School , University of Limerick , Limerick , Ireland.

Introduction: Individual placental and umbilical cord morphometry have been previously identified to have an association with fetal growth. This study aims to identify which of the morphometric measurements in combination are associated with pregnancies with small for gestational age (SGA) infants using digital imaging of the delivered placenta.

Material And Methods: This study examined 1005 placentas from consecutively delivered singleton pregnancies in a tertiary center. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582628DOI Listing
February 2019

Toll-Like Receptor 9, maternal cell-free dna and myometrial cell response to cpg oligodeoxynucleotide stimulation.

Am J Reprod Immunol 2019 Feb 13:e13100. Epub 2019 Feb 13.

Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215.

Problem: Among mechanisms triggering onset of parturition, it has been recently postulated that Toll-Like Receptor (TLR)9 engagement by cell-free DNA (cfDNA) triggers inflammation, myometrial contractions and labor in absence of infection. The current study evaluated whether direct (myometrial) or indirect (decidual) TLR9 engagement enhances human myometrial contractility.

Method Of Study: TLR9 expression and cellular localization were surveyed by immunohistochemistry of placenta, fetal membranes, and myometrium in term (gestational age [GA]:>37 weeks) labor (TL, n=7) or term non-labor (TNL, n=7) tissues. Read More

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http://dx.doi.org/10.1111/aji.13100DOI Listing
February 2019

Time from referral to ovarian tissue cryopreservation in a cohort of Danish women.

Acta Obstet Gynecol Scand 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.

Introduction: Young women with a cancer diagnosis often have very little time to decide whether or not to commence on fertility preserving strategies before initiating potentially sterilizing cancer treatment. Minimizing the interval from opting for fertility preservation to completion of the procedure will reduce the potential risk of delaying cancer treatment. In the current study, we have evaluated the period of time from referral to ovarian tissue cryopreservation (OTC) to actual freezing of the tissue in a cohort of Danish women. Read More

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http://dx.doi.org/10.1111/aogs.13575DOI Listing
February 2019

Elective egg freezing without medical indications.

Acta Obstet Gynecol Scand 2019 Feb 13. Epub 2019 Feb 13.

Wales fertility Institute, Cardiff University, Cardiff, UK.

The aim of this review is to provide current knowledge on fertility preservation for nonmedical reasons in women willing to postpone childbearing. The topic is highly debatable starting from the disagreement about its terminology, the number of eggs necessary to predict chances of success, and the safety and socio/ethical point of view. Cost analysis and discrepancies among countries recommendations and regulations are described to confirm the controversies and unsolved issues around this very interesting topic. Read More

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http://dx.doi.org/10.1111/aogs.13573DOI Listing
February 2019

Prevention of Cesarean Delivery Surgical Site Infections.

Obstet Gynecol Surv 2019 Feb;74(2):99-110

Professor and Director, Division of Specialists in Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC.

Importance: Surgical site infection (SSI) is a common complication of cesarean delivery. Seen in up to 12% of cesarean deliveries, it is a major cause of prolonged hospital stay and a burden to the healthcare system. Interventions and techniques must be identified to decrease the risk of cesarean delivery SSIs. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000645DOI Listing
February 2019

The health of children conceived by ART: 'the chicken or the egg?'

Hum Reprod Update 2019 Feb 12. Epub 2019 Feb 12.

Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark.

Worldwide, more than 7 million children have now been born after ART: these delivery rates are steadily rising and now comprise 2-6% of births in the European countries. To achieve higher pregnancy rates, the transfer of two or more embryos was previously the gold standard in ART. However, recently the practise has moved towards a single embryo transfer policy to avoid multiple births. Read More

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http://dx.doi.org/10.1093/humupd/dmz001DOI Listing
February 2019
3 Reads

Advances in Biomarker Studies in Autism Spectrum Disorders.

Adv Exp Med Biol 2019 ;1118:207-233

College of Life Science and Oceanography, Shenzhen University, Shenzhen, People's Republic of China.

Autism spectrum disorder (ASD) is a neurological and developmental condition that begins early in childhood and lasts throughout life. The epidemiology of ASD is continuously increasing all over the world with huge social and economical burdens. As the etiology of autism is not completely understood, there is still no medication available for the treatment of this disorder. Read More

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http://dx.doi.org/10.1007/978-3-030-05542-4_11DOI Listing
January 2019

Emergent Prophylactic, Reparative and Restorative Brain Interventions for Infants Born Preterm With Cerebral Palsy.

Front Physiol 2019 28;10:15. Epub 2019 Jan 28.

The Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, The University of Sydney Medical School, Sydney, NSW, Australia.

Worldwide, an estimated 15 million babies are born preterm (<37 weeks' gestation) every year. Despite significant improvements in survival rates, preterm infants often face a lifetime of neurodevelopmental disability including cognitive, behavioral, and motor impairments. Indeed, prematurity remains the largest risk factor for the development of cerebral palsy. Read More

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http://dx.doi.org/10.3389/fphys.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360173PMC
January 2019
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Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches.

Placenta 2019 Jan 28. Epub 2019 Jan 28.

Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.

In the 1930s the "progestin" hormone produced by the corpus luteum was isolated and found to be a Δ-keto-steroid. It was aptly named progesterone (P4) and in the following 30 years the capacity of P4 and derivatives to prevent preterm birth (PTB) was examined. Outcomes of multiple small studies suggested that progestin prophylaxis beginning at mid-gestation decreases the risk for PTB. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.01.018DOI Listing
January 2019
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Reassessing the length of labour in healthy Turkish women: a retrospective and descriptive study.

J Obstet Gynaecol 2019 Feb 11:1-6. Epub 2019 Feb 11.

d Biometry and Genetics Unit, Faculty of Agriculture , Akdeniz University , Antalya , Turkey.

This study aims to use the partograph among Turkish women to (a) assess birth curves, (b) define the phase duration of labour, and (c) identify the factors that affect labour. This study was conducted with 496 women and features a retrospective descriptive analysis and a cross-sectional design. The mean duration for the active phase was 5. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1534811DOI Listing
February 2019
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Thromboprophylaxis in Patients with Acute Spinal Cord Injury: A Narrative Review.

Semin Thromb Hemost 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Patients with acute spinal cord injury (SCI) have the highest risk of venous thromboembolism (VTE) among hospitalized patients. The incidence of total deep vein thrombosis ranges from 50 to 100% in untreated patients and pulmonary embolism is the third most common cause of mortality in these patients. The pathophysiology of the increased risk of VTE is explained by venous stasis after injury, endothelial vessel wall injury from surgery, and a hypercoagulable state associated with trauma. Read More

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http://dx.doi.org/10.1055/s-0039-1678720DOI Listing
February 2019
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Impact of TP53 immunohistochemistry on the histological grading system for endometrial endometrioid carcinoma.

Mod Pathol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

Endometrial endometrioid carcinoma is usually divided into three histological subgroups: grade 1 (G1), grade 2 (G2), and grade 3 (G3). Most cases of endometrial endometrioid carcinoma G1/2 have a favorable prognosis, although some can have unfavorable outcomes, especially when they involve elderly patients, with similarities to endometrioid carcinoma G3 and serous carcinoma. This retrospective study evaluated whether TP53 abnormalities in endometrial endometrioid carcinoma could be used to supplement the current grading system and improve its ability to predict clinical outcomes. Read More

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http://dx.doi.org/10.1038/s41379-019-0220-1DOI Listing
February 2019

Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.

Int J Gynecol Pathol 2019 Feb 7. Epub 2019 Feb 7.

TeLinde Gynecologic Pathology Research Program, Department of Gynecology and Obstetrics (T.T.Y., T.L.W., I.M.S., S.G.) Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics (T.T.Y., A.N.F., S.G.) Department of Pathology (T.L.W.) Department of Oncology (S.G.), Johns Hopkins University School of Medicine, Baltimore, Maryland.

Recent advances in molecular studies, especially genome-wide analyses, have revealed the landscape of genomic alterations present in endometrial carcinomas, and have provided valuable insight into the pathogenesis of this disease. The current challenges are in developing a molecular-morphologic classification system to enhance traditional pathologic diagnosis and in determining the optimal approach to using this new information to guide clinical management. Molecular assays may be particularly beneficial in allowing the earlier detection of endometrial cancer or precursor lesions and in guiding personalized treatment approaches. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000585DOI Listing
February 2019

Current Realities of Childbearing in Residency: Room for Improvement.

Authors:
Marti D Soffer

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

From the Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1097/AOG.0000000000003120DOI Listing
February 2019

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.

J Inherit Metab Dis 2019 Jan;42(1):5-28

Department of Clinical Genomics, Mayo Clinic, Rochester, New York.

Phosphomannomutase 2 (PMM2-CDG) is the most common congenital disorder of N-glycosylation and is caused by a deficient PMM2 activity. The clinical presentation and the onset of PMM2-CDG vary among affected individuals ranging from a severe antenatal presentation with multisystem involvement to mild adulthood presentation limited to minor neurological involvement. Management of affected patients requires a multidisciplinary approach. Read More

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http://dx.doi.org/10.1002/jimd.12024DOI Listing
January 2019
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Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy.

J Anat 2019 Feb 10. Epub 2019 Feb 10.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.

Pelvic floor disorders negatively impact millions of women worldwide. Although there is a strong epidemiological association with childbirth, the mechanisms leading to the dysfunction of the integral constituents of the female pelvic floor, including pelvic floor skeletal muscles, are not well understood. This is in part due to the constraints associated with directly probing these muscles, which are located deep in the pelvis. Read More

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http://dx.doi.org/10.1111/joa.12943DOI Listing
February 2019
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Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics.

Cell Mol Gastroenterol Hepatol 2018 Oct 24;7(2):411-431. Epub 2018 Oct 24.

Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background & Aims: A generalized human pacemaking syndrome, chronic atrial and intestinal dysrhythmia (CAID) (OMIM 616201), is caused by a homozygous SGO1 mutation (K23E), leading to chronic intestinal pseudo-obstruction and arrhythmias. Because CAID patients do not show phenotypes consistent with perturbation of known roles of SGO1, we hypothesized that noncanonical roles of SGO1 drive the clinical manifestations observed.

Methods: To identify a molecular signature for CAID syndrome, we achieved unbiased screens in cell lines and gut tissues from CAID patients vs wild-type controls. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.011DOI Listing
October 2018

Management of early pregnancy loss, with a focus on patient centered care.

Semin Perinatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, University of Pennsylvania, 3400 Spruce Street, 1000 Courtyard, Philadelphia, PA 19104, USA.

Early pregnancy loss is the most common complication in pregnancy. Management options for miscarriage include expectant management, medical intervention, or surgical aspiration. Non-surgical and surgical management are all safe and acceptable options for medically uncomplicated patients. Read More

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http://dx.doi.org/10.1053/j.semperi.2018.12.005DOI Listing
December 2018