619 results match your criteria Current Neurovascular Research[Journal]


Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of mice models.

Curr Neurovasc Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Shanghai Eighth People's Hospital, Shanghai. China.

Introduction: The purpose of this investigation was to elucidate whether miR-125b targeting p38MAPK could relieve cognitive impairment of obstructive sleep apnea hypopnea syndrome (OSAHS) mice models.

Material And Methods: The mice models were categorized into untreated control (UC), 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (CIH) and 5% chronic intermittent hypoxia (CIH) groups. Morris Water Maze, spatial navigation test and spatial probe test were conducted to appraise the learning, memorizing and cognitive abilities of mice models. Read More

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http://dx.doi.org/10.2174/1567202616666190211155309DOI Listing
February 2019
1 Read

The U-shaped relationship between serum methylene tetrahydrofolate reductase and large-artery atherosclerotic stroke.

Curr Neurovasc Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA. United States.

Introduction: Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms has been suggested to be associated with ischemic stroke. However, the association between serum MTHFR level and ischemic stroke has not yet been studied. We aimed to examine the association between them in patients with large-artery atherosclerotic stroke and community-based healthy controls. Read More

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http://dx.doi.org/10.2174/1567202616666190207161818DOI Listing
February 2019
1 Read
2.253 Impact Factor

MicroRNAs for the Treatment of Dementia and Alzheimer's Disease.

Authors:
Kenneth Maiese

Curr Neurovasc Res 2019 Feb 7. Epub 2019 Feb 7.

Neurology and Neurosciences UMDNJ 205 South Orange Avenue, F1220 Newark, NJ 07101, United States.

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http://dx.doi.org/10.2174/1567202616666190208094159DOI Listing
February 2019

Long-term outcomes of cerebral venous sinus stenosis corrected by stenting

Curr Neurovasc Res 2019 02 6. Epub 2019 Feb 6.

Departments of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

Background And Purpose: Cerebral venous sinus stenosis (CVSS) usually results in severe intracranial hypertension (IH), which can be corrected by stenting immediately. However, there is a lack of evidence of the long-term good outcomes in patients with CVSS who underwent stenting.

Methods: A total of 62 patients with imaging confirmed non-thrombotic and non-external compression CVSS were enrolled into this single center real-world cohort study after undergoing stenting, and were continuously followed up for more than 12 years. Read More

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http://dx.doi.org/10.2174/1567202616666190206185133DOI Listing
February 2019
1 Read

Ameliorative effect of Phosphodiesterase-5 inhibitor in Rat model of Vascular Dementia.

Curr Neurovasc Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi university, Patiala- 147002, Punjab. India.

Cerebral hypoperfusion has been associated with increased risk of vascular dementia (VaD). The present study investigates the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced VaD. Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Read More

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http://dx.doi.org/10.2174/1567202616666190130153954DOI Listing
January 2019
1 Read

Alanine aminotransferase predicts outcomes in elderly patients with aneurysmal subarachnoid hemorrhage.

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, NO.1 of Youyi Rd, Yuzhong District, Chongqing. China.

Objective: With the aging of the world population, a growing number of elderly patients suffered from aneurysmal subarachnoid hemorrhage (aSAH). We aim to investigate the potential association between plasma ALT level and clinical complications of elderly aSAH patients, and explore its predictive value for clinical outcomes of elderly aSAH patients.

Patients And Methods: Between January 2013 and March 2018, 152 elderly aSAH patients were analyzed in this study. Read More

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http://www.eurekaselect.com/169459/article
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http://dx.doi.org/10.2174/1567202616666190130094631DOI Listing
January 2019
5 Reads

Elevated inflammatory parameter levels negatively correlate with populations of circulating stem cells (CD133+), early endothelial progenitor cells.

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Pomeranian Medical University, Szczecin. Poland.

Background: Endothelial progenitor cells (EPCs) are important players in neovascularization, mobilized through signalling by angiogenic growth factors (AGFs) such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). In vitro, inflammatory parameters impair the function and influence of EPCs on AGFs. However, this connection is not clear in vivo. Read More

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http://dx.doi.org/10.2174/1567202616666190129164906DOI Listing
January 2019
1 Read

Changes in Cognition, Depression and Quality of Life after Carotid Stenosis Treatment.

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Pauls Stradins Clinical University Hospital, Department of Neurology, Riga. Latvia.

Background: Although several studies have evaluated the change of cognitive performance after severe carotid artery stenosis (CAS), the results still remain elusive. The objective of this study was to assess changes in cognitive function, depressive symptoms and health-related quality of life (HRQoL) after CAS revascularisation and best medical treatment (BMT).

Methods: Study involved 213 patients with severe (≥70%) CAS who underwent assessment of cognitive function using Montreal Cognitive Assessment scale (MoCA), depressive symptoms - using Patient Health Questionnaire-9 (PHQ-9) and HRQoL - using Medical Outcome Survey Short Form version 2 (SF-36v2). Read More

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http://dx.doi.org/10.2174/1567202616666190129153409DOI Listing
January 2019
3 Reads

Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study.

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Departments of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, IL. United States.

Background: Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circulation, such as with CAS, increase compensatory flow demands via the Circle of Willis (COW) and may induce similar stress at the basilar apex.

Objective: We present a series of nine unruptured basilar apex aneurysms (BAA) with CAS and a comparative radiographic analysis to BAA without CAS. Read More

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http://dx.doi.org/10.2174/1567202616666190129150403DOI Listing
January 2019

Glucose levels and outcome after primary intraventricular hemorrhage.

Curr Neurovasc Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan. China.

Objectives: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous intracerebral hemorrhage (ICH), but the association between blood glucose level and outcomes in primary intraventricular hemorrhage (PIVH) remains unclear. We sought to identify the parameters associated with admission hyperglycemia and analyze the impact of hyperglycemia on clinical outcome in patients with PIVH.

Methods: Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between 2010 and 2016 were retrospectively included in our study. Read More

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http://dx.doi.org/10.2174/1567202616666190131164108DOI Listing
January 2019

Current medical and surgical stroke prevention therapies for patients with carotid artery stenosis.

Curr Neurovasc Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo. Norway.

Carotid artery stenosis (CAS) is a marker of systemic atherosclerosis and patients with CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains controversial. Read More

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http://dx.doi.org/10.2174/1567202616666190131162811DOI Listing
January 2019

Intracranial aneurysms in sickle cell disease: A systematic review and case-control study.

Curr Neurovasc Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurosurgery, University Hospital of Essen. Germany.

Background: The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs.

Objective: To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD). Read More

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http://dx.doi.org/10.2174/1567202616666190131160847DOI Listing
January 2019
1 Read

Autophagy-Inhibition potentiates cell death and its Activation by trehalose does not protect hippocampal HT22 neurons against cell death induced by ER-Stress.

Authors:
L Halbe A Rami

Curr Neurovasc Res 2019 Jan 31. Epub 2019 Jan 31.

Institut für Zelluläre und Molekulare Anatomie (Anatomie III), Klinikum der Johann Wolfgang von Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt/Main. Germany.

ER stress leads to the activation of two protein degradation pathways, the ubiquitin-proteasome via ER-associated degradation and lysosome-mediated protein degradation via autophagy. ER-associated degradation involves translocation of unfolded ER proteins to the cytosol where they are ubiquitinated and degraded by the proteasome. When the accumulation of misfolded or unfolded proteins excels the ER capacity, autophagy can be activated in order to degrade accumulated proteins and thus attenuate ER stress. Read More

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http://dx.doi.org/10.2174/1567202616666190131155834DOI Listing
January 2019

Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(4):326-335

Center of Cerebrovascular Disease, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background And Purpose: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS).

Methods: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission. Read More

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http://dx.doi.org/10.2174/1567202616666181204122457DOI Listing
January 2018
3 Reads

Combining Diffusion-Weighted Imaging Patterns with ABCD2 Score Predicts Stroke Risk after Transient Ischemic Attack.

Curr Neurovasc Res 2018 ;15(4):298-304

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Background: Recent studies indicated that multiple acute infarctions on Diffusion- Weighted Imaging (DWI) were associated with a higher risk of stroke.

Objective: The study aims to estimate the association of different infarction patterns and ABCD2 score with the prognosis of Transient Ischemic Attack (TIA).

Method: We prospectively analyzed the data from TIA database of the First Affiliated Hospital of Zhengzhou University. Read More

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http://dx.doi.org/10.2174/1567202616666181204121636DOI Listing
January 2018
2 Reads

Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.

Authors:
Kenneth Maiese

Curr Neurovasc Res 2018 Nov 28. Epub 2018 Nov 28.

Cellular and Molecular Signaling Newark, New Jersey 07101. United States.

The world's population continues to age at a rapid pace. By the year 2050, individuals over the age of 65 will account for sixteen percent of the world's population and life expectancy will increase well over eighty years of age. Accompanied with the aging of the global population is a significant rise in non-communicable diseases (NCDs). Read More

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http://dx.doi.org/10.2174/1567202616666181128120003DOI Listing
November 2018
1 Read

Gender-Specific Relationship Between Uric Acid Levels and Prognosis After Cerebral Venous Thrombosis.

Curr Neurovasc Res 2018 ;15(4):292-297

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Background: Uric Acid (UA) has been known to play a neuroprotective role in ischemic stroke patients. However, the relationship between UA levels and prognosis in patients with Cerebral Venous Thrombosis (CVT) has not been investigated.

Method: A total of 228 CVT patients were retrospectively identified and were divided into three groups according to UA levels. Read More

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http://dx.doi.org/10.2174/1567202616666181127163321DOI Listing
January 2018
4 Reads

Blood Pressure and the Risk of Dementia: A Dose-Response Meta-Analysis of Prospective Studies.

Curr Neurovasc Res 2018 ;15(4):345-358

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shadong, China.

Background: A number of epidemiological studies have revealed a controversial correlation between Blood Pressure (BP) and the risk of dementia, hindering translation of research into preventative practice.

Objective: To meta-analyze the dose-response relationship of dementia and its subtypes to BP.

Method: Relevant studies were identified via a systematic retrieval analysis in electronic databases from inception to May 1, 2017. Read More

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http://dx.doi.org/10.2174/1567202616666181128114523DOI Listing
January 2018
1 Read

9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics.

Curr Neurovasc Res 2018 ;15(4):312-325

Cannon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY 14260, United States.

Background: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW).

Method: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left Common Carotid Artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries. Read More

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http://dx.doi.org/10.2174/1567202616666181127165943DOI Listing
January 2018
2 Reads

Elevated Serum Human Cytomegalovirus IgM Levels in the Acute Phase of Ischemic Stroke are Associated with Increased Risk of Death and Major Disability.

Curr Neurovasc Res 2018 ;15(4):305-311

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China.

Background: There was a lack of studies on the association between Human Cytomegalovirus (HCMV) infection and prognosis of ischemic stroke, although it was indicated that human cytomegalovirus DNA has played a role in several cardiovascular disorders.

Objective: To examine the association between HCMV IgM levels in the acute phase and death and major disability after 2 weeks of acute ischemic stroke.

Methods: Serum HCMV IgM levels were measured in 1150 participants in China. Read More

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http://dx.doi.org/10.2174/1567202616666181123150917DOI Listing
January 2018
12 Reads
2.253 Impact Factor

Bradykinin Receptors in Ischemic Injury.

Curr Neurovasc Res 2018 ;15(4):359-366

Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003, China.

Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed. Read More

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http://dx.doi.org/10.2174/1567202616666181123151629DOI Listing
January 2018
10 Reads

NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis.

Curr Neurovasc Res 2018 ;15(4):276-281

Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China.

Background: While the NOD-Like Receptor Protein-3 (NLRP3) inflammasome is involved in a variety of nervous system diseases, its role in epilepsy still needs to be further investigated.

Methods: The expressions of NLRP3 inflammasome and apoptosis related proteins were examined by Western blot. MTT was used to assess cell viability. Read More

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http://dx.doi.org/10.2174/1567202616666181122165540DOI Listing
January 2018
9 Reads
2.253 Impact Factor

ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease.

Curr Neurovasc Res 2018 ;15(4):336-344

Division of Neurotoxicology National Center for Toxicological Research (NCTR), FDA, White Oak, MD-20993, United States.

Introduction: Parkinson's Disease (PD) is a debilitating, age-related disorder characterized by selective degeneration of dopaminergic neurons in the midbrain substantia nigra (SNc). Dopaminergic neurons originating in the midbrain project to the striatum (Caudate-putamen-CPU). Although studies have suggested that the extracellular signal-regulated kinase ½ (ERK ½) in the brain is activated after 1-Methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) exposure, to our knowledge no study has yet been done to demonstrate whether such activation occurs in neurons or in glia. Read More

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http://dx.doi.org/10.2174/1567202616666181123152601DOI Listing
January 2018
10 Reads
2.253 Impact Factor

Are Cerebral Perfusion and Atrophy Linked in Multiple Sclerosis? Evidence for a Multifactorial Approach to Assess Neurodegeneration.

Curr Neurovasc Res 2018 ;15(4):282-291

IRCCS, Fondazione Don Carlo Gnocchi ONLUS, via Capecelatro 66, 20148 Milan, Italy.

Background: Grey Matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages.

Objective: We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Read More

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http://dx.doi.org/10.2174/1567202616666181123164235DOI Listing
January 2018
7 Reads

A Piece of the ROCK: A Critical Role for Rho Kinases in the Nervous System.

Authors:
Kenneth Maiese

Curr Neurovasc Res 2018 Nov 22. Epub 2018 Nov 22.

Neurology and Neurosciences UMDNJ 205 South Orange Avenue, F1220 Newark, NJ 07101. United States.

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http://dx.doi.org/10.2174/1567202616999181122160902DOI Listing
November 2018
1 Read

MicroRNA-490-5P Targets CCND1 to Suppress Cellular Proliferation in Glioma Cells and Tissue Through Cell Cycle Arrest.

Curr Neurovasc Res 2018 ;15(3):246-255

Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.

Background: Glioma is a type of tumor that starts in the glial cells of brain and spine. However, the underlying molecular mechanisms of miRNAs dysregulation in glioma initiation and progression is largely unclear.

Objective: To further understand the molecular mechanism of miR-490-5P functions and how miR-490 regulated CCND1 function. Read More

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http://dx.doi.org/10.2174/1567202615666180813130143DOI Listing
January 2018
2 Reads

Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.

Curr Neurovasc Res 2018 ;15(3):234-245

Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala-147002, Punjab, India.

Aim: The aim of the present work was to explore the outcome of combination of Calcineurin (CaN) inhibitor and Protein Kinase A (PKA) activator, in mouse models of experimental dementia.

Methods: Cognitive deficits were induced in mice by injecting Streptozotocin (STZ) intracerebroventricularly (i.c. Read More

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http://dx.doi.org/10.2174/1567202615666180813125125DOI Listing
January 2018
2 Reads
2.253 Impact Factor

Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model.

Curr Neurovasc Res 2018 ;15(3):186-192

First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Background: Epilepsy is a chronic neurological disorder affecting an estimated 50 million people worldwide. Emerging evidences have accumulated over the past decades supporting the role of inflammation in the pathogenesis of epilepsy. Curcumin is a nature-derived active molecule demonstrating anti-inflammation efficacy. Read More

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http://dx.doi.org/10.2174/1567202615666180731100224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327116PMC
January 2018
13 Reads

Cerebral Inflow and Outflow Discrepancies in Severe Sudden Sensorineural Hearing Loss.

Curr Neurovasc Res 2018 ;15(3):220-225

Vascular Diseases Center, University Hospital of Ferrara, Ferrara, Italy.

The aim of this study is to evaluate whether cerebral inflow and outflow abnormalities, assessed by the means of a validated ultrasound model, could be associated with Sudden Sensorineural Hearing Loss (SSNHL). According to Clark, a total of 42 patients affected by severe SSNHL and 19 healthy volunteers matched by gender without any history of sudden hearing impairment have been included in this study. Patients and controls underwent EchocolorDoppler assessment of brain hemodynamics. Read More

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http://dx.doi.org/10.2174/1567202615666180727091955DOI Listing
January 2018
4 Reads

Reduced Hemoglobin Levels Combined with an Increased Plasma Concentration of Vasoconstrictive endothelin-1 are Strongly Associated with Poor Outcome During Acute Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(3):193-203

The Department of Neurology, Pomeranian Medical University, Szczecin, Poland.

The association of poor outcome and mortality with low levels of hemoglobin (Hb) and hematocrit (HcT) in patients admitted after acute Ischemic Stroke (IS) was recently demonstrated. The mechanisms behind this still remain unclear. Our study aims to find out whether mRNA expressions and plasma concentrations of endothelin-1 (ET-l), endothelin-2 (ET-2) and endothelin-3 (ET-3) remain different in IS sufferers with low HcT and Hb levels in comparison with those whose HcT i Hb levels during a severe IS episode remain within the norm. Read More

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http://dx.doi.org/10.2174/1567202615666180726101531DOI Listing
January 2018
2 Reads

Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases.

Authors:
Seidu A Richard

Curr Neurovasc Res 2018 ;15(3):262-273

Department of Surgery, Volta Regional Hospital, P.O. Box MA-374, Ho, Ghana, West Africa.

Chlamydia Pneumoniae (C. Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. Read More

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http://dx.doi.org/10.2174/1567202615666180717161807DOI Listing
January 2018
13 Reads
2.253 Impact Factor

Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patients Receiving Thrombectomy: Standard or Low Dose Therapy?

Curr Neurovasc Res 2018 ;15(3):204-210

Department of Neurology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: We compared the clinical outcomes of low and standard dose recombinant tissue Plasminogen Activator (rtPA) treatment in Acute Ischemic Stroke (AIS) patients receiving Endovascular Mechanical Thrombectomy (EVT).

Methods: Between April 01, 2015 and September 30, 2017, all AIS patients admitted to the Linkou and Chiayi Chang Gung Memorial Hospital were retrospectively reviewed. Patients with large vessel occlusions, who underwent bridging therapy with rtPA and EVT, were further enrolled. Read More

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http://dx.doi.org/10.2174/1567202615666180717113526DOI Listing
January 2018
5 Reads

"Micromanaging" Glioblastoma Multiforme: The Potential of MicroRNAs, Circular RNAs, and the Hippo Pathway as Novel Treatment Strategies.

Authors:
Kenneth Maiese

Curr Neurovasc Res 2018 ;15(3):173-174

Neurology and Neurosciences UMDNJ 205 South Orange Avenue, F1220 Newark, NJ 07101, United States.

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http://dx.doi.org/10.2174/1567202615999180711123907DOI Listing
January 2018
2 Reads

Genetic Determinants of Cerebral Arterial Adaptation to Flow-loading.

Curr Neurovasc Res 2018 ;15(3):175-185

Departments of Neurosurgery, University of Cincinnati, Cincinnati, OH, United States.

Background: In animal models, flow-loading is a necessary and sufficient hemodynamic factor to express the Cerebral Aneurysm (CA) phenotype. Using a rat model, this study characterizes the molecular events that comprise the cerebral arterial response to flow-loading and reveals their significance relating to the CA phenotype.

Objective: To characterize the molecular events that underlie expansive remodeling of cerebral arteries in two genetically distinct inbred rat strains with differential susceptibility to flow-dependent cerebrovascular pathology. Read More

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http://dx.doi.org/10.2174/1567202615666180712150143DOI Listing
January 2018
4 Reads

LncRNA MALAT1 is Neuroprotective in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury Through miR-204 Regulation.

Curr Neurovasc Res 2018 ;15(3):211-219

Department of Spinal Surgery, The Second Hospital of Shandong University, Ji`nan, China.

Background: This study was to investigate the neuroprotective effect of long noncoding RNAs Metastasis associated lung adenocarcinoma transcript-1 (lncRNA MALAT-1) in Spinal Cord Ischemic/Reperfusion Injury (SCIRI).

Methods: Quantitative real-time PCR (RT-qPCR) was used to examine the expressions of MALAT1, miR-204 and Bcl-2, while western blot was performed to examine Bcl-2. Besides, apoptosis was evaluated by the percentage of cell viability and apoptotic cells. Read More

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http://dx.doi.org/10.2174/1567202615666180712153150DOI Listing
January 2018
4 Reads

Extracranial-to-Intracranial Bypass for Pressor Dependent Cerebrovascular Insufficiency: Modified Classification and Representative Case.

Curr Neurovasc Res 2018 ;15(3):256-261

Department of Neurological Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, United States.

Background: While some randomized clinical trials have reduced the indications for cerebral revascularization in the secondary prevention of ischemic stroke, a distinct subset of patients with blood pressure augmentation dependent cerebrovascular insufficiency due to large vessel occlusions remains unaddressed. With the recent paradigm shifts in acute ischemic stroke care, the role of extracranial to intracranial (EC-IC) bypass must be re-addressed when endovascular intervention is not a feasible option. We submit a refined classification of cerebrovascular insufficiency with a category called Pressor-Dependent Cerebrovascular Insufficiency (PD-CVI) for whom EC-IC bypass may be indicated. Read More

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http://dx.doi.org/10.2174/1567202615666180712155028DOI Listing
January 2018
21 Reads

Elevated C-reactive Protein and Depressed High-density Lipoprotein Cholesterol are Associated with Poor Function Outcome After Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(3):226-233

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States.

Aims: C-reactive protein is an established marker of inflammation that can impair the protective function of High Density Lipoprotein Cholesterol (HDL-C). The combined effect of Creactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain.

Methods: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) were included in this analysis. Read More

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http://dx.doi.org/10.2174/1567202615666180712100440DOI Listing
January 2018
3 Reads
2.250 Impact Factor

Prognostic Value of White Blood Cell in Acute Ischemic Stroke Patients.

Curr Neurovasc Res 2018 ;15(2):151-157

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States.

Background And Aims: It is unclear whether white blood cell on admission has a prognosis value on ischemic stroke and whether its function is affected by other inflammation factors. We hypothesized that elevated white blood cell is associated with stroke severity and 3-month mortality after acute ischemic stroke.

Methods: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) were included in this analysis. Read More

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http://dx.doi.org/10.2174/1567202615666180626154857DOI Listing
January 2018
3 Reads

Statins Therapy is Associated with Increased Populations of Early Endothelial Progenitor (CD133+/VEGFR2+) and Endothelial (CD34-/CD133- /VEGFR2+) Cells in Patients with Acute Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(2):120-128

Department of Neurology, Pomeranian Medical University, Szczecin, Poland.

Background: Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients with AIS. Read More

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http://dx.doi.org/10.2174/1567202615666180611120546DOI Listing
January 2018
2 Reads

Safety and Efficiency of Low Dose Intra-arterial Tirofiban in Mechanical Thrombectomy During Acute Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(2):145-150

Department of Internal Neurology, Shanghai Tenth People's Hospital of Tongji University, Middle Yanchang Rd. 301#, Zhabei District, Shanghai 200072, China.

Objective: In this study, we aimed to evaluate the safety and efficiency of low dose intra- arterial tirofiban in mechanical thrombectomy of acute ischemic stroke patients to facilitate the reperfusion of distal vessel.

Methods: We retrospectively analyzed 54 consecutive acute ischemic patients who underwent mechanical thrombectomy for large-vessel occlusion. Patients were divided into two groups based on whether intra-arterial tirofiban was used during mechanical thrombectomy to facilitate the reperfusion of distal vessel. Read More

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http://dx.doi.org/10.2174/1567202615666180605104931DOI Listing
January 2018
17 Reads

MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy.

Curr Neurovasc Res 2018 ;15(2):103-110

Department of Neurology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory for Neurology, Hebei, 050000, China.

Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Read More

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http://dx.doi.org/10.2174/1567202615666180601081409DOI Listing
January 2018
3 Reads

Intracranial Fluid Dynamics Changes in Idiopathic Intracranial Hypertension: Pre and Post Therapy.

Curr Neurovasc Res 2018 ;15(2):164-172

Laboratory of Applied Mathematics, University of Trento, Trento, TN, Italy.

Objective: Idiopathic Intracranial Hypertension (IIH) is a condition of unknown etiology frequently associated with dural sinus stenosis. There is emerging evidence that venous sinus stenting is an effective treatment. We use phase contrast cine MRI to observe changes in flow dynamics of multiple intracranial fluids and their response to different treatments in a patient with IIH. Read More

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http://dx.doi.org/10.2174/1567202615666180528113616DOI Listing
January 2018
6 Reads

Bradykinin B2 receptors play a neuroprotective role in Hypoxia/reoxygenation injury related to pyroptosis pathway.

Curr Neurovasc Res 2018 ;15(2):138-144

Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, China.

Background: Kinins are pro-inflammatory peptides that mediate numerous vascular and pain responses in tissue injury. Kinins exert their biological functions via two G-protein-coupled receptors: Bradykinin 1 Receptor (B1R) and Bradykinin 2 Receptor (B2R). We previously demonstrated the up-regulation of B2R after Hypoxia/Reoxygenation (H/R) injury in primary cultured cortical neurons. Read More

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http://www.eurekaselect.com/162473/article
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http://dx.doi.org/10.2174/1567202615666180528073141DOI Listing
January 2018
11 Reads

Onjisaponin B (OB) is Neuroprotective During Cognitive Loss Through Immune-mediated and SIRT1 Pathways.

Curr Neurovasc Res 2018 ;15(2):94-102

Department of Neurology, Heilongjiang Provincial Hospital, Harbin, China.

Background: The purpose of the present study was to investigate the effects of Onjisaponin B (OB) in lipopolysaccharide (LPS)-induced cognitive deficits.

Methods: The rats were divided into four groups: sham group, LPS group (the model group), LPS + OB (1 mg/kg) group and LPS + OB (2 mg/kg) group. OB was treated three days before surgery and thereafter continuously for 7 days. Read More

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http://dx.doi.org/10.2174/1567202615666180528071520DOI Listing
January 2018
3 Reads

Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage.

Curr Neurovasc Res 2018 ;15(2):158-163

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

Background: The impact of Total Bile Acids (TBA) level on clinical outcomes after acute Intracerebral Hemorrhage (ICH) is still not understood.

Objective: We investigated whether admission TBA level is associated with hematoma volume, stroke clinical severity, and 3-month outcomes in acute ICH patients.

Methods: A total of 335 ICH patients were prospectively enrolled. Read More

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http://dx.doi.org/10.2174/1567202615666180516114211DOI Listing
January 2018
6 Reads

A Novel Neuroimaging Model to Predict Early Neurological Deterioration After Acute Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(2):129-137

Department of Neurology, Chang Gung Memorial Hospital at Chiayi, Chang-Gung University, College of Medicine, Putz, Taiwan.

Objective: In acute ischemic stroke, early neurological deterioration (END) may occur in up to one-third of patients. However, there is still no satisfying or comprehensive predictive model for all the stroke subtypes. We propose a practical model to predict END using magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.2174/1567202615666180516120022DOI Listing
January 2018
4 Reads

Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke.

Curr Neurovasc Res 2018 ;15(2):111-119

Department of Neurology, Changhua Christian Hospital, Changhua 500, Taiwan.

Background: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke.

Method: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Read More

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http://dx.doi.org/10.2174/1567202615666180516120959DOI Listing
January 2018
4 Reads

Dampening the Progression of Dementia.

Authors:
Kenneth Maiese

Curr Neurovasc Res 2018 ;15(2):93

Neurology and Neurosciences UMDNJ 205 South Orange Avenue, F1220 Newark, NJ 07101, United States.

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http://dx.doi.org/10.2174/1567202615666180510165839DOI Listing
January 2018
1 Read

MiR-29 Targets PUMA to Suppress Oxygen and Glucose Deprivation/Reperfusion (OGD/R)-induced Cell Death in Hippocampal Neurons.

Curr Neurovasc Res 2018 ;15(1):47-54

Department of Urologic Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, NO. 355, Luding Road, Shanghai, 200062, China.

Introduction: We previously demonstrated that microRNAs (miRNA) play an important role in Hypothermic Circulatory Arrest (DHCA)-associated neural injury. However, the specific role of miRNAs in the pathogenesis of DHCA-induced neuron death is still unclear.

Material And Methods: Thus, in the present study, we investigated miR-29 expression and roles in neuronal HT-22 cells with Oxygen-glucose Deprivation/reoxygenation (OGD/R). Read More

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http://dx.doi.org/10.2174/1567202615666180403170902DOI Listing
January 2018
9 Reads

Levosimendan Reduces Prostaglandin F2a-dependent Vasoconstriction in Physiological Vessels and After Experimentally Induced Subarachnoid Hemorrhage.

Curr Neurovasc Res 2018 ;15(1):72-80

Department of Neurosurgery, Goethe-University Hospital, Frankfurt am Main, Germany.

Background: Delayed cerebral vasospasm (dCVS) following aneurysmal subarachnoid hemorrhage (aSAH) is (next to possible aneurysm rebleeding, cortical spreading depression and early brain injury) one of the main factors contributing to poor overall patient outcome. Since decades, intensive research has been ongoing with the goal of improving our understanding of the pathophysiological principles underlying dCVS. Endothelin-1 (ET-1) and prostaglandin F2 alpha (PGF2a) seem to play a major role during dCVS. Read More

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http://dx.doi.org/10.2174/1567202615666180328121025DOI Listing
January 2018
38 Reads