838 results match your criteria Current Neuropharmacology[Journal]


The Forgotten Cells: Role of Astrocytes in Mood Disorders During the Aging.

Curr Neuropharmacol 2019 ;17(5):404-405

Instituto de Investigacion Biomedica de Malaga-IBIMA. Departamento de Psicobiologia y Metodologia de las Ciencias del Comportamiento, Facultad de Psicologia, Universidad de Malaga, Spain.

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http://dx.doi.org/10.2174/1570159X1705190405151808DOI Listing
January 2019

Monoamines and their derivatives on GPCRs: potential therapy for Alzheimer's Disease.

Curr Neuropharmacol 2019 Apr 9. Epub 2019 Apr 9.

Departamentos de Fisiología y Bioquímica. Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina. Instituto Politécnico Nacional. Plan de San Luis y Diaz Mirón s/n, 11340, Mexico City. Mexico.

Albeit cholinergic depletion remains the key event in Alzheimer's Disease (AD), recent information describes stronger links between monoamines (trace amines, catecholamines, histamine, serotonin, and melatonin) and AD than those known in the past century. Therefore, new drug design strategies focus efforts to translate the scope on these topics and to offer new drugs which can be applied as therapeutic tools in AD. In the present work, we reviewed the state-of-art regarding genetic, neuropathology and neurochemistry of AD involving monoamine systems. Read More

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http://dx.doi.org/10.2174/1570159X17666190409144558DOI Listing
April 2019
1 Read
3.049 Impact Factor

Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review.

Curr Neuropharmacol 2019 Apr 9. Epub 2019 Apr 9.

Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University; "Sant'Andrea" University Hospital, Rome. Italy.

Background: Obsessive-compulsive disorder (OCD) is highly prevalent, severe, chronic, and disabling. There is need for alternative strategies for treatment-resistant OCD.

Objective: This review aims to assess the effect of brain stimulation techniques in OCD. Read More

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http://dx.doi.org/10.2174/1570159X17666190409142555DOI Listing
April 2019
1 Read

Drug Treatment Of Trichotillomania (Hair-Pulling Disorder), Excoriation (Skin-Picking) Disorder, And Nail-Biting (Onychophagia).

Curr Neuropharmacol 2019 Mar 20. Epub 2019 Mar 20.

Universita degli Studi di Roma La Sapienza Facolta di Medicina e Psicologia Ringgold standard institution - NeSMOS Piazzale Aldo Moro , Roma 00185. Italy.

Background: Trichotillomania (TTM), excoriation (or skin-picking) disorder and some severe forms of onychophagia are classified under obsessive-compulsive and related disorders. There are different interacting neurotransmitter systems involved in the pathophysiology of impulse-control disorders, implicating noradrenaline, serotonin, dopamine, opioid peptides and glutamate, hence investigators focused on drugs able to act on these transmitters. Our aim was to critically review the efficacy of the drugs employed in impulse-control disorders. Read More

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http://dx.doi.org/10.2174/1570159X17666190320164223DOI Listing
March 2019
4 Reads

Far-infrared ray-mediated antioxidant potentials are important for attenuating psychotoxic disorders.

Curr Neuropharmacol 2019 Feb 27. Epub 2019 Feb 27.

Neuropsychopharmacology and Toxicology Program, BK21 PLUS Project, College of Pharmacy, Kangwon National University, Chunchon 24341. Korea.

Far-infrared ray (FIR) is an electromagnetic wave that produces various health benefits against pathophysiological conditions, such as diabetes mellitus, renocardiovascular disorders, stress, and depression etc. However, the therapeutic application on the FIR-mediated protective potentials remains to be further extended. To achieve the better understanding on FIR-mediated therapeutic potentials, we summarized additional findings in the present study that exposure to FIR ameliorates stressful condition, memory impairments, drug dependence, and mitochondrial dysfunction in the central nervous system. Read More

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http://dx.doi.org/10.2174/1570159X17666190228114318DOI Listing
February 2019

Association between serum lipids and antipsychotic response in schizophrenia.

Curr Neuropharmacol 2019 Feb 27. Epub 2019 Feb 27.

Department of Psychiatry, University of British Columbia, Vancouver, BC. Canada.

Metabolic abnormalities are serious health problems in individuals with schizophrenia. Paradoxically, studies have noted an association where individuals who gained body weight or who have increases in their serum lipids demonstrated better antipsychotic response. As serum lipids serve as more specific physiological markers than body weight, the objective of this study was to review studies that examined the association between changes in serum lipids and changes in symptoms during antipsychotic treatment in individuals with schizophrenia. Read More

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http://dx.doi.org/10.2174/1570159X17666190228113348DOI Listing
February 2019
3.049 Impact Factor

Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde?

Authors:
Michel Baudry

Curr Neuropharmacol 2019 Feb 27. Epub 2019 Feb 27.

Graduate College of Biomedical Sciences Western University of Health Sciences Pomona, CA 91766. United States.

While the calpain system has now been discovered for over 50 years, there is still a paucity of information regarding the organization and functions of the signaling pathways regulated by these proteases, although calpains play critical roles in many cell functions. Moreover, calpain overactivation has been shown to be involved in numerous diseases. Among the 15 calpain isoforms identified, calpain-1 (aka µ-calpain) and calpain-2 (aka m-calpain) are ubiquitously distributed in most tissues and organs, including the brain. Read More

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http://dx.doi.org/10.2174/1570159X17666190228112451DOI Listing
February 2019
1 Read

Pharmacotherapy for hoarding disorder: How did the picture change since its excision from OCD?

Curr Neuropharmacol 2019 Jan 24. Epub 2019 Jan 24.

Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, School of Medicine and Psychology, Sapienza University, Rome. Italy.

This brief review deals with the various issues that contributed to the creation of the new Diagnostic and Statistical Manual condition of hoarding disorder (HD) and attempts at reviewing its pharmacotherapy. It appears that after the newly founded diagnosis appeared in the literature as an autonomous entity, distinct from obsessive-compulsive disorder, drug trials are not being conducted and the disorder is left in the hands of psychotherapists, who on their part, report fair results in some core dimensions of HD. The few trials on HD specifically regard the serotonin-noradrenaline reuptake inhibitor venlafaxine, and, possibly due to the suggestion of a common biological background of HD with attention deficit/hyperactivity disorder, the psychostimulant methylphenidate and the noradrenaline reuptake inhibitor atomoxetine. Read More

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http://dx.doi.org/10.2174/1570159X17666190124153048DOI Listing
January 2019
1 Read

Why Should Psychiatrists and Neuroscientists Worry about Paraoxonase 1?

Curr Neuropharmacol 2018 12 27. Epub 2018 Dec 27.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Background: Nitro-oxidative stress (NOS) has been implicated in the pathophysiology of psychiatric disorders. The activity of the polymorphic antioxidant enzyme paraoxonase 1 (PON1) is altered in diseases where NOS is involved. PON1 activity may be estimated using different substrates some of which are influenced by PON1 polymorphisms. Read More

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http://dx.doi.org/10.2174/1570159X17666181227164947DOI Listing
December 2018
20 Reads

NLRP3 inflammasome in the pathophysiology of hemorrhagic stroke: A Review.

Curr Neuropharmacol 2018 Dec 27. Epub 2018 Dec 27.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang. China.

Hemorrhagic stroke is a devastating disease with high morbidity and mortality. There is still a lack of effective therapeutic approach. The recent studies have shown that the innate immune system plays a significant role in hemorrhagic stroke. Read More

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http://dx.doi.org/10.2174/1570159X17666181227170053DOI Listing
December 2018
12 Reads
3.049 Impact Factor

Pharmacological Approaches Targeting Brain Cell Survival in the Context of Neurodegeneration and Potential Treatment Strategies.

Authors:
Gjumrakch Aliev

Curr Neuropharmacol 2019 ;17(3):198-200

President "GALLY" International Biomedical Research Institute San Antonio, TX, United States.

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http://dx.doi.org/10.2174/1570159X17666181227163039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425073PMC
January 2019
1 Read

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences.

Curr Neuropharmacol 2018 Dec 27. Epub 2018 Dec 27.

Neurology Clinic, University of Perugia - S. Maria della Misericordia Hospital, Perugia. Italy.

After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regulation of ionic currents and the facilitation of GABAergic over glutamatergic transmission. As a result, VPA indirectly modulates neurotransmitter release and strengthens the threshold for seizure activity. Read More

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http://dx.doi.org/10.2174/1570159X17666181227165722DOI Listing
December 2018
25 Reads

The Era of Cerebellar Therapy.

Curr Neuropharmacol 2019 ;17(1):3-6

Service de Neurologie, CHUCharleroi, Charleroi, Belgium.

Major advances in our understanding of the neurology/pathology, anatomy/physiology, and molecular biology of the cerebellum have opened a new door for cerebellar ataxias (CAs). We have now entered in the 'era of therapies'. Cures are knocking at the door. Read More

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http://dx.doi.org/10.2174/1570159X1701181129111212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341497PMC
April 2019
12 Reads

Preface.

Authors:
Thomas E Salt

Curr Neuropharmacol 2019 ;17(1)

Institute of Ophthalmology University College London London EC1V 9EL, United Kingdom.

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http://dx.doi.org/10.2174/1570159X1701181129110951DOI Listing
April 2019
1 Read

Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Department of Applied Science, Indian Institute of Information Technology, Allahabad, Uttar Pradesh. India.

Olfaction, the sense of smell detects and discriminate odors as well as social cues which influence our innate responses. The olfactory system in human beings is found to be weak as compare to other animals; however, it seems to be very precise. It can detect and discriminate millions of chemical moieties (odorants) even in minuscule quantities. Read More

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http://dx.doi.org/10.2174/1570159X17666181206095626DOI Listing
December 2018
12 Reads
3.049 Impact Factor

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires. Argentina.

Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Read More

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http://dx.doi.org/10.2174/1570159X17666181206101314DOI Listing
December 2018
15 Reads

Application of the Co-Agonist Concerted Transition Model to Analysis of GABAA Receptor Properties.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO. United States.

The co-agonist concerted transition model is a simple and practical solution to analyzing various aspects of GABAA receptor function. Several model-based predictions have been verified experimentally in previous reports. We review here the practical implications of the model and demonstrate how it enables simplification of the experimental procedure and data analysis to characterize the effects of mutations or properties of novel ligands. Read More

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http://dx.doi.org/10.2174/1570159X17666181206092418DOI Listing
December 2018
2 Reads

Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease.

Curr Neuropharmacol 2019 ;17(3):295-306

EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine, Corunna 15166, Spain.

The research progress of understanding the etiology and pathogenesis of Parkinson's disease (PD) has yet lead to the development of some clinical approaches intended to treat cognitive and behavioral symptoms, such as memory and perception disorders. Despite the major advances in different genetic causes and risk factors for PD, which share common pathways to cell dysfunction and death, there is not yet a complete model of PD that can be used to accurately predict the effect of drugs on disease progression. Clinical trials are also important to test any novel neuro-protective agent, and recently there have been great advances in the use of anti-inflammatory drugs and plant flavonoid antioxidants to protect against specific neuronal degeneration and its interference with lipid and cholesterol metabolism. Read More

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http://dx.doi.org/10.2174/1570159X17666181127125704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425078PMC
January 2019
13 Reads

Evolving Mechanistic Concepts Of Epileptiform Synchronization And Their Relevance In Curing Focal Epileptic Disorders.

Curr Neuropharmacol 2018 Nov 27. Epub 2018 Nov 27.

Montreal Neurological Institute of Physiology, McGill University, Montréal, H3A 2B4 Québec. Canada.

The synchronized activity of neuronal networks under physiological conditions is mirrored by specific oscillatory patterns of the EEG that are associated with different behavioral states and cognitive functions. Excessive synchronization can however lead to focal epileptiform activity characterized by interictal and ictal discharges in epileptic patients and animal models. This review focusses on studies that have addressed epileptiform synchronization in temporal lobe regions by employing in vitro and in vivo recording techniques. Read More

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http://dx.doi.org/10.2174/1570159X17666181127124803DOI Listing
November 2018
5 Reads

Systematic Review of Food Addiction as Measured With the Yale Food Addiction Scale: Implications for the Food Addiction Construct.

Curr Neuropharmacol 2018 Nov 7. Epub 2018 Nov 7.

Geneva University Hospitals, Geneva. Switzerland.

Background: The concept of food addiction attracts much interest by the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. Read More

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http://dx.doi.org/10.2174/1570159X16666181108093520DOI Listing
November 2018
7 Reads

Placebo effect in Obsessive-Compulsive Disorder (OCD). Placebo response and placebo responders in OCD: The trend over time.

Curr Neuropharmacol 2018 10 26. Epub 2018 Oct 26.

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Background: Placebo response appears to be increasing in antidepressant, antipsychotic and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999. Placebo response is generally considered as the extent to which placebo treatment is associated with core symptom improvement. Read More

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http://www.eurekaselect.com/166688/article
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http://dx.doi.org/10.2174/1570159X16666181026163922DOI Listing
October 2018
33 Reads
3.050 Impact Factor

Special Issue on Programmed Cell Death in Stroke.

Authors:
Qin Hu

Curr Neuropharmacol 2018 ;16(9):1254

Discipline of Neuroscience Department of Physiology and Anatomy Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.

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http://dx.doi.org/10.2174/1570159X1609181005102948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251053PMC
November 2018
1 Read

Omics-based biomarkers for the early Alzheimer Disease diagnosis and reliable therapeutic targets development.

Curr Neuropharmacol 2018 Sep 26. Epub 2018 Sep 26.

Neonatal Research Unit, Health Research Institute La Fe, Valencia. Spain.

Background: Alzheimer's disease (AD), the most common cause of dementia in adulthood, has a great medical, social, and economic impact worldwide. Available treatments result in symptomatic relief, and most of them are indicated from early stages of the disease. Therefore, there is an increasing body of research developing accurate and early diagnoses, as well as disease-modifying therapies. Read More

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http://dx.doi.org/10.2174/1570159X16666180926123722DOI Listing
September 2018
2 Reads

Alzheimer's Disease - Future Therapy Based on Dendrimers.

Curr Neuropharmacol 2019 ;17(3):288-294

Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow Region, Chernogolovka, 142432, Russian Federation.

Alzheimer's disease (AD) is characterized by the loss of neurons. It is the most common cause of dementia in the elderly population accompanied by pathological degeneration of neurofibrillary tangles. Senile plaques are formed with beta-amyloid, hyperphosphoryled tau protein, apolipoprotein E and presenilin associated with protease activity [amyloid beta (Aβ), gamma-secretase (γS)]. Read More

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http://dx.doi.org/10.2174/1570159X16666180918164623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425077PMC
January 2019
12 Reads
3.049 Impact Factor

Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.

Curr Neuropharmacol 2019 ;17(1):33-58

University of Washington, School of Medicine, Seattle, WA 98109, United States.

Immune-mediated cerebellar ataxias (IMCAs), a clinical entity reported for the first time in the 1980s, include gluten ataxia (GA), paraneoplastic cerebellar degenerations (PCDs), antiglutamate decarboxylase 65 (GAD) antibody-associated cerebellar ataxia, post-infectious cerebellitis, and opsoclonus myoclonus syndrome (OMS). These IMCAs share common features with regard to therapeutic approaches. When certain factors trigger immune processes, elimination of the antigen( s) becomes a priority: e. Read More

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http://dx.doi.org/10.2174/1570159X16666180917105033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341499PMC
April 2019
4 Reads

Traumatic Brain Injury altered Normal Brain Signaling Pathways: Implications for Novel Therapeutics approaches.

Curr Neuropharmacol 2018 Sep 11. Epub 2018 Sep 11.

Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga, Punjab. India.

Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide. In the United state alone, 1.7 million traumatic events occur yearly, out of which 50,000 results in deaths. Read More

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http://dx.doi.org/10.2174/1570159X16666180911121847DOI Listing
September 2018
4 Reads
3.050 Impact Factor

Astragaloside IV supplementation promotes a neuroprotective effect in experimental models of neurological disorders: a systematic review.

Curr Neuropharmacol 2018 09 11. Epub 2018 Sep 11.

Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte (UERN), Mossoró/RN. Brazil.

Background: Neurological disorders constitute a growing worldwide concern due to the progressive aging of the population and the risky behavior they represent. Herbal medicines have scientific relevance in the treatment of these pathologies. One of these substances, Astragaloside IV (AS-IV), is the main active compound present in the root of Astragalus membranaceus (Fisch. Read More

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http://dx.doi.org/10.2174/1570159X16666180911123341DOI Listing
September 2018
2 Reads

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update.

Curr Neuropharmacol 2019 ;17(3):247-267

Department of Nano-Therapeutics, Institute of Nano Science & Technology, Habitat Centre, Phase X, Mohali-160062, Punjab, India.

Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. Read More

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http://www.eurekaselect.com/165303/article
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http://dx.doi.org/10.2174/1570159X16666180911124605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425075PMC
January 2019
21 Reads
3.050 Impact Factor

Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules.

Curr Neuropharmacol 2019 ;17(3):268-287

Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russian Federation.

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic symptoms of PD are caused by degeneration of nigrostriatal dopamine neurons. Read More

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http://dx.doi.org/10.2174/1570159X16666180905094123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425072PMC
January 2019
2 Reads

Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders.

Curr Neuropharmacol 2019 ;17(1):7-13

Department of Neurology, German Center for Vertigo and Balance Disorders, and Institute for Clinical Neurosciences, University Hospital Munich, Campus Grosshadern, Munich, Germany.

Cerebellar ataxia is a frequent and often disabling syndrome severely impairing motor functioning and quality of life. Patients suffer from reduced mobility, and restricted autonomy, experiencing an even lower quality of life than, e.g. Read More

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http://dx.doi.org/10.2174/1570159X16666180905093535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341500PMC
April 2019
6 Reads

Psychobiology of Eating Disorders - a Gateway to Precision Medicine.

Curr Neuropharmacol 2018;16(8):1100-1101

Department of Psychological Medicine Section of Eating Disorders King's College London London, United Kingdom.

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http://dx.doi.org/10.2174/1570159X1608180821144325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187756PMC
January 2018
12 Reads

Different generations of type-B monoamine oxidase inhibitors in Parkinson's disease: from bench to bedside.

Curr Neuropharmacol 2018 Aug 29. Epub 2018 Aug 29.

Department of Physiology and Pharmacolofy University Sapienza of Rome Piazzale Aldo Moro, 5, 00185, Rome. Italy.

Three inhibitors of type-B monoamine oxidase (MAOB), selegiline, rasagiline, and safinamide, are used for the treatment of Parkinson's disease (PD). All three drugs improve motor signs of PD, and are effective in reducing motor fluctuations in patients undergoing long-term L-DOPA treatment. Their effect of MAOB inhibitors on non-motor symptoms is not uniform and may not be class-related. Read More

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http://dx.doi.org/10.2174/1570159X16666180830100754DOI Listing
August 2018
9 Reads

Towards a Dynamic Exploration of Vision, Cognition and Emotion in Alcohol-Use Disorders.

Curr Neuropharmacol 2018 08 27. Epub 2018 Aug 27.

Laboratory for Experimental Psychopathology, Psychological Science Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium

Visuoperceptive impairments are among the most frequently reported deficits in alcohol-use disorders, but only very few studies have investigated their origin and interactions with other categories of dysfunctions. Besides, these deficits have generally been interpreted in a linear bottom-up perspective, which appears very restrictive with respect to the new models of vision developed in healthy populations. Indeed, new theories highlight the predictive nature of the visual system and demonstrate that it interacts with higher-level cognitive functions to generate top-down predictions. Read More

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http://dx.doi.org/10.2174/1570159X16666180828100441DOI Listing
August 2018
2 Reads

Current Progress on Peroxisome Proliferator-activated Receptor Gamma Agonist as an Emerging Therapeutic Approach for the Treatment of Alzheimer's Disease: An Update.

Curr Neuropharmacol 2019 ;17(3):232-246

Department of Biochemistry, Hind Institute of Medical Sciences, Sitapur-2613013, India.

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder, characterized by the deposition of amyloid-β within the brain parenchyma resulting in a significant decline in cognitive functions. The pathophysiological conditions of the disease are recognized by the perturbation of synaptic function, energy and lipid metabolism. In Addition deposition of amyloid plaques also triggers inflammation upon the induction of microglia. Read More

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http://dx.doi.org/10.2174/1570159X16666180828100002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425074PMC
January 2019
10 Reads

Psychopharmacotherapy of obsessive-compulsive symptoms within the framework of Tourette syndrome.

Curr Neuropharmacol 2018 Aug 27. Epub 2018 Aug 27.

Department of Child and Adolescent Psychiatry and Psychotherapy TU Dresden. Germany.

While Behavioral Therapy (BT) should be recommended as the first step in the treatment of OCD as well as TS, medication can be added for augmentation and in certain situations (e.g. family preference, BT not available or feasible) the priority may even reverse. Read More

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http://dx.doi.org/10.2174/1570159X16666180828095131DOI Listing
August 2018
15 Reads

School-based Prevention for Adolescent Internet Addiction: Prevention is the Key. A Systematic Literature Review.

Curr Neuropharmacol 2018 Aug 13. Epub 2018 Aug 13.

Psychology Department, Nottingham Trent University, Nottingham. United Kingdom.

Adolescents' media use represents a normative need for information, communication, recreation and functionality, yet problematic Internet use has increased. Given the arguably alarming prevalence rates worldwide and the increasingly problematic use of gaming and social media, the need for an integration of prevention efforts appears to be timely. The aim of this systematic literature review is (i) to identify school-based prevention programmes or protocols for Internet Addiction targeting adolescents within the school context and to examine the programmes' effectiveness, and (ii) to highlight strengths, limitations, and best practices to inform the design of new initiatives, by capitalizing on these studies' recommendations. Read More

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http://dx.doi.org/10.2174/1570159X16666180813153806DOI Listing
August 2018
2 Reads

Psychopharmacological treatment of Obsessive-Compulsive Disorder (OCD).

Curr Neuropharmacol 2018 08 13. Epub 2018 Aug 13.

Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University; Unit of Psychiatry, Sant'Andrea University Hospital, Rome. Italy.

Background: Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.

Objective: Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field. Read More

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http://dx.doi.org/10.2174/1570159X16666180813155017DOI Listing
August 2018
43 Reads

The action of polyphenols in Diabetes Mellitus and Alzheimer's disease: a common agent for overlapping pathologies.

Curr Neuropharmacol 2018 Aug 3. Epub 2018 Aug 3.

University of Beira Interior, Rua Marques d'Avila e Bolama, 6201-001 Covilha. Portugal.

Diabetes Mellitus (DM) and Alzheimer's disease (AD) are two prevalent diseases in modern societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has already been demonstrated that these two diseases are associated since individuals suffering from DM are prone to develop AD. Conversely, it is also known that individuals with AD are more susceptible to DM, namely type 2 diabetes (T2DM). Read More

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http://dx.doi.org/10.2174/1570159X16666180803162059DOI Listing
August 2018
2 Reads

Molecular Mechanism of Aniline Induced Spleen Toxicity and Neuron Toxicity in Experimental Rat Exposure: A Review.

Curr Neuropharmacol 2019 ;17(3):201-213

Research Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. However, the molecular mechanism(s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and DNA subsequently, in the spleen. Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. Read More

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http://dx.doi.org/10.2174/1570159X16666180803164238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425079PMC
January 2019
2 Reads

Glaucoma: In Search of Better Neurotherapeutics.

Curr Neuropharmacol 2018;16(7):902

Department of Pharmacy, Health and Nutritional Sciences University of Calabria 87036 Arcavacata di Rende, Italy.

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http://dx.doi.org/10.2174/1570159X1607180712164222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120107PMC
January 2018
1 Read

Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer's Disease.

Curr Neuropharmacol 2019 ;17(2):176-183

Department of Human Neuroscience, Sapienza, University of Rome, Rome, Italy.

The pathogenesis of Alzheimer's disease (AD) is somewhat complex and has yet to be fully understood. As the effectiveness of the therapy currently available for AD has proved to be limited, the need for new drugs has become increasingly urgent. The modulation of the endogenous cannabinoid system (ECBS) is one of the potential therapeutic approaches that is attracting a growing amount of interest. Read More

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http://dx.doi.org/10.2174/1570159X16666180702144644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343203PMC
January 2019
4 Reads

Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression.

Curr Neuropharmacol 2019 ;17(5):459-471

Laboratorio de Farmacologia Conductual, Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz, Calzada Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Delegacion Tlalpan, 14370, Ciudad de Mexico, Mexico.

Background: In women, changes in estrogen levels may increase the incidence and/or symptomatology of depression and affect the response to antidepressant treatments. Estrogen therapy in females may provide some mood benefits as a single treatment or might augment clinical response to antidepressants that inhibit serotonin reuptake.

Objective: We analyzed the mechanisms of estradiol action involved in the regulation of gene expression that modulates serotonin neurotransmission implicated in depression. Read More

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http://dx.doi.org/10.2174/1570159X16666180628165107DOI Listing
January 2019
4 Reads

Estrogen and Serotonin: Complexity of Interactions and Implications for Epileptic Seizures and Epileptogenesis.

Curr Neuropharmacol 2019 ;17(3):214-231

Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.

A burgeoning literature documents the confluence of ovarian steroids and central serotonergic systems in the injunction of epileptic seizures and epileptogenesis. Estrogen administration in animals reduces neuronal death from seizures by up-regulation of the prosurvival molecule i.e. Read More

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http://dx.doi.org/10.2174/1570159X16666180628164432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425080PMC
January 2019
6 Reads
3.050 Impact Factor

Editorial: In Silico Studies in Drug Research Against Neurodegenerative Diseases.

Curr Neuropharmacol 2018;16(6):647-648

Federal University of Paraiba Campus I, 58051-900 Joao Pessoa-PB, Brazil.

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http://dx.doi.org/10.2174/1570159X1606180608103840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080093PMC
January 2018
1 Read

Functional and structural neural changes in obsessive-compulsive disorder after pharmacotherapy.

Authors:
Murad Atmaca

Curr Neuropharmacol 2018 Jun 12. Epub 2018 Jun 12.

Firat University, School of Medicine, Department of Psychiatry, Elazig. Turkey.

Obsessive-compulsive disorder (OCD) is a disorder which is important and disturbing the quality of life and is characterized by repetitive thoughts and behaviors, now in a different category in the Diagnostic and Statistical Manual for Mental Disorders Fifth Edition (DSM 5). Neuroimaging investigations are very useful to reveal a neurobiological model of the OCD. Studies conducted in the last quarter century have shown clear results and revealed that specific cortico-subcortical circuits could be involved in the occurrence of OCD symptomatology. Read More

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http://dx.doi.org/10.2174/1570159X16666180613074059DOI Listing
June 2018
3 Reads

P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke.

Curr Neuropharmacol 2018 ;16(9):1282-1295

Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.

Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and cell death is widely believed to occur after exposure to blood metabolites or subsequently damaged cells. Recently, programmed cell death, such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, has been demonstrated to play crucial roles in the pathophysiology of stroke. However, the detailed mechanisms of these novel kinds of cell death are still unclear. Read More

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http://www.eurekaselect.com/162179/article
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http://dx.doi.org/10.2174/1570159X16666180516094500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251042PMC
November 2018
5 Reads

Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury.

Curr Neuropharmacol 2018 ;16(9):1358-1364

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lot of evidence that Mst1 plays an important role in cell death which results from tissue injury. Previous studies have shown that Mst1 is not only a target for some apoptosis- related molecules such as caspase 3 and P53, but also act as an activator of these proteinases to magnify apoptosis signal pathways. Read More

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http://www.eurekaselect.com/162182/article
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http://dx.doi.org/10.2174/1570159X16666180516095949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251045PMC
November 2018
4 Reads

Editorial: The Role of Ca2+-activated K+ Channels of Intermediate Conductance in Glioblastoma Malignancy.

Curr Neuropharmacol 2018;16(5):607

Department of Chemistry, Biology and Biotechnology University of Perugia, via Pascoli 8, 06123 Perugia, Italy.

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http://dx.doi.org/10.2174/1570159X1605180510154222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997871PMC
October 2018
1 Read

Editorial: Glia-Neuron Crosstalk and its Therapeutic Implication in Neuropsychiatric Disorders.

Authors:
Yong-Ku Kim

Curr Neuropharmacol 2018;16(5):506-507

Department of Psychiatry, College of Medicine Korea University, Seoul, Korea.

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http://dx.doi.org/10.2174/1570159X1605180510145459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997863PMC
October 2018
2 Reads