306 results match your criteria Current Molecular Pharmacology [Journal]


Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro.

Curr Mol Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut. Lebanon.

Background: Colorectal cancer (CRC) is a common cause of oncological deaths worldwide. Alterations of the epigenetic landscape constitute are a well-documented hallmark of CRC phenotype. Accumulation of aberrant DNA methylation and histone acetylation plays a major role in altering gene activity and driving tumor onset, progression and metastasis. Read More

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http://dx.doi.org/10.2174/1874467212666190313154531DOI Listing
March 2019
1 Read

Bafilomycin-A1 and ML9 exert different lysosomal actions to induce cell death.

Curr Mol Pharmacol 2019 Mar 8. Epub 2019 Mar 8.

Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas &Facultad de Medicina, Universidad de Chile, Santiago. Chile.

Objective: Bafilomycin-A1 and ML9 are lysosomotropic agents, irrespective of cell types. However, the mechanisms of lysosome targeting of either bafilomycin-A1 or ML9 are unclear.

Methods: The present research has been carried out by different molecular and biochemical analyses like western blot, confocal imaging and FACS studies, as well as molecular docking. Read More

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http://dx.doi.org/10.2174/1874467212666190308131250DOI Listing

Mesalazine activates adenosine monophosphate-activated protein kinase: Implication in the anti-inflammatory activity of this anti-colitic drug.

Curr Mol Pharmacol 2019 Mar 7. Epub 2019 Mar 7.

College of Pharmacy, Pusan National University, Busan 609-735. Korea.

Objective: Mesalazine, 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug that is most widely used for the treatment of inflammatory bowel disease (IBD). Despite extensive clinical use, the exact pharmacological mechanism underlying the anti-colitic effects of 5-ASA has not yet been elucidated. A potential molecular mechanism underlying 5-ASA-mediated anti-colitic activity was investigated. Read More

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http://dx.doi.org/10.2174/1874467212666190308103448DOI Listing

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy.

Curr Mol Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah. United Arab Emirates.

Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA migrates from food and beverage containers into the contents when heated or even under normal conditions of use. BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERα and ERβ. Read More

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http://dx.doi.org/10.2174/1874467212666190306164507DOI Listing
March 2019
1 Read

In-vitro pre-treatment of cancer cells with TGF-β1: A novel approach of Tail vein lung cancer metastasis mouse model for anti-metastatic studies.

Curr Mol Pharmacol 2019 03 6. Epub 2019 Mar 6.

Jiangsu key laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009. China.

Background: Aggressive behavior of tumor metastasis comes from certain mutations, changes in cellular metabolic and signaling pathways that are majorly altered by tumor microenvironment (TME), its other components and growth factors like transforming growth factor-β1 (TGF-β1) which is chiefly known for its epithelial to mesenchymal transformation (EMT). EMT is a critical step of metastasis cascade in actual human lung cancer scenario.

Objective: Our present study is focused to unveil the in-vivo metastatic behavior of TGF-β1 treated lung cancer cells that undergone EMT. Read More

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http://dx.doi.org/10.2174/1874467212666190306165703DOI Listing
March 2019
2 Reads

Assessment of Genotoxicity of Levosimendan in Human Cultured Lymphocytes.

Curr Mol Pharmacol 2019 ;12(2):160-165

Department of Clinical Pharmacy; College of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Background And Objective: Levosimendan is a positive inotropic and a vasodilator agent with pleotropic characteristics that include antioxidation, anti-inflammation and smooth muscle vasodilation.

Methods: In this study, the effects of levosimendan (0, 0.1, 1, 10, and 20 µg/ml) on oxidative DNA damage and sister-chromatid exchanges (SCEs) were evaluated in human cultured lymphocytes. Read More

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http://dx.doi.org/10.2174/1874467212666190306164926DOI Listing
January 2019

Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.

Curr Mol Pharmacol 2019 Mar 4. Epub 2019 Mar 4.

Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California. United States.

The ancient and highly evolutionarily conserved Wnt signaling pathway is critical in nearly all tissues and organs for an organism to develop normally from embryo through adult. Wnt signaling is generally parsed into "canonical" or Wnt-β catenin-dependent or "non-canonical" β catenin-independent signaling. Even though designating Wnt signaling as either canonical or non-canonical allows for easier conceptual discourse about this signaling pathway, in fact canonical and non-canonical Wnt crosstalk regulates complex nonlinear networks. Read More

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http://dx.doi.org/10.2174/1874467212666190304121131DOI Listing

Targeting Chromatin Remodeling for Cancer Therapy.

Curr Mol Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina. United States.

Background: Epigenetic alterations comprise key regulatory events that dynamically alter gene expression and their deregulation is commonly linked to the pathogenesis of various diseases, including cancer. Unlike DNA mutations, epigenetic alterations involve modifications to proteins and nucleic acids that regulate chromatin structure without affecting the underlying DNA sequence, altering the accessibility of the transcriptional machinery to the DNA, thus modulating gene expression. In cancer cells, this often involves the silencing of tumor suppressor genes or the increased expression of genes involved in oncogenesis. Read More

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http://dx.doi.org/10.2174/1874467212666190215112915DOI Listing
February 2019
1 Read

New Insights in Cannabinoid Receptor Structure and Signaling.

Curr Mol Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Biochemistry and Molecular Biology, College of Life Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang. China.

Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic targets for treating pain, addiction, obesity, inflammation, and other diseases. Recent studies have suggested that in addition to CB1 and CB2, there are non-CB1 and non-CB2 cannabinoid-related orphan GPCRs including GPR18, GPR55, and GPR119. Read More

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http://dx.doi.org/10.2174/1874467212666190215112036DOI Listing
February 2019

Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone.

Curr Mol Pharmacol 2019 ;12(2):139-146

Zydus Research Centre, Cadila Healthcare Limited, Sarkhej-Bavla N.H.No.8A, Moraiya, Ahmedabad, 382210, India.

Background: Balanced coagonists of glucagon-like peptide-1 (GLP-1) and glucagon receptors are emerging therapies for the treatment of obesity and diabetes. Such coagonists also regulate lipid metabolism, independent of their body weight lowering effects. Many actions of the coagonists are partly mediated by fibroblast growth factor 21 (FGF21) signaling, with the major exception of bile homeostasis. Read More

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http://dx.doi.org/10.2174/1874467212666190212112402DOI Listing
January 2019
1 Read

Alterations of RNA Metabolism by Proteomic Analysis of Breast Cancer Cells Exposed to Marycin: A New Optically Active Porphyrin.

Curr Mol Pharmacol 2019 ;12(2):147-159

Molecular Mechanism Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Objective: Marycin is a porphyrin-type compound synthetically modified to spontaneously release fluorescence. This study is aimed at understanding possible mechanisms that could account for the antiproliferative effects observed in marycin. A proteomic approach was used to identify molecular effects. Read More

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http://dx.doi.org/10.2174/1874467212666190204102112DOI Listing
January 2019

Preface.

Authors:
Michael Kahn

Curr Mol Pharmacol 2019 ;12(1)

Beckman Research Institute City of Hope Duarte, CA 91010-3000, United States.

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http://dx.doi.org/10.2174/187446721201190103111612DOI Listing
January 2019
1 Read

Mephedrone Impact on Matrix Metalloproteinases Activity - Do they Influence the Memory Processes?

Curr Mol Pharmacol 2019 ;12(2):115-121

Laboratory of Behavioral Research, Jaczewskiego 8d Str., Medical University of Lublin, Lublin, Poland.

Background: The use of drugs of addiction, as mephedrone, is associated with functional neuronal disorders due to remodeling of the nervous tissue. Key enzymes in remodeling are extracellular matrix (ECM) proteases like matrix metalloproteases (MMPs). Recently, MMPs have been of great interest as some studies point to a fact that the alterations in structural remodeling of synaptic connections modify learning-dependent changes, which remain active even after a prolonged period of abstinence. Read More

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http://dx.doi.org/10.2174/1874467212666190114154307DOI Listing
January 2019
11 Reads

A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia.

Curr Mol Pharmacol 2019 Jan 11. Epub 2019 Jan 11.

J.K.K. Nattraja College of Pharmacy, Kumarapalayam 638183. India.

Background: Diabetes mellitus and concomitant dyslipidemia, being referred to as 'diabetic dyslipidemia', are the foremost detrimental factors documented to play a pivotal role in cardiovascular illness. Diabetic dyslipidemia is associated with insulin resistance, high plasma triglyceride levels, low HDL-cholesterol concentration and elevated small dense LDL-cholesterol particles. Maintaining an optimal glucose and lipid levels in patients afflicted with diabetic dyslipidemia could be a major task that might require a well-planned diet-management system and regular physical activity, or otherwise an intake of a combined antidiabetic and antihyperlipidemic medications. Read More

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http://www.eurekaselect.com/168923/article
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http://dx.doi.org/10.2174/1874467212666190111165015DOI Listing
January 2019
11 Reads

Therapeutic Potential of Morin in Ovalbumin-induced Allergic Asthma Via Modulation of SUMF2/IL-13 and BLT2/NF-kB Signaling Pathway.

Curr Mol Pharmacol 2019 ;12(2):122-138

Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune-411 038, India.

Background: Allergic asthma is a chronic immune-inflammatory disorder, characterized by airway inflammation and airway hyperresponsiveness (AHR). Morin is a natural flavonoid reported to exhibit inhibitory action against IgE-mediated allergic response.

Aim: To determine the efficacy of murine model of ovalbumin (OVA)-induced AHR inhibition by morin and decipher the molecular mechanism involved. Read More

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http://dx.doi.org/10.2174/1874467212666190102105052DOI Listing
January 2019
2 Reads

MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells.

Curr Mol Pharmacol 2019 ;12(2):105-114

Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang 421001, Hunan Province, China.

Background: Alterations in microRNAs (miRNAs) are related to the occurrence of nasopharyngeal carcinoma (NPC) and play an important role in the molecular mechanism of NPC. Our previous studies show low expression of 14-3-3σ (SFN) is related to the metastasis and differentiation of NPC, but the underlying molecular mechanisms remain unclear.

Methods: Through bioinformatics analysis, we find miR-597 is the preferred target miRNA of 14-3-3σ. Read More

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http://www.eurekaselect.com/168418/article
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http://dx.doi.org/10.2174/1874467212666181218113930DOI Listing
January 2019
10 Reads

Mitochondria-Targeted Drugs.

Curr Mol Pharmacol 2018 Nov 27. Epub 2018 Nov 27.

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow. Russian Federation.

Background: Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs. A number of pathologies are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory and metabolic conditions. Read More

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http://www.eurekaselect.com/167790/article
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http://dx.doi.org/10.2174/1874467212666181127151059DOI Listing
November 2018
22 Reads

Does the Development of Vaccines Advance Solutions for Tuberculosis?

Curr Mol Pharmacol 2019 ;12(2):83-104

Department of Medical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Background: Mycobacterium tuberculosis (Mtb) is considered as one of the most efficacious human pathogens. The global mortality rate of TB stands at approximately 2 million, while about 8 to 10 million active new cases are documented yearly. It is, therefore, a priority to develop vaccines that will prevent active TB. Read More

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http://dx.doi.org/10.2174/1874467212666181126151948DOI Listing
January 2019
25 Reads

Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy.

Curr Mol Pharmacol 2019 ;12(1):61-71

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan-333031, India.

Background: Natriuretic peptide system (NPS) alterations are involved in pathogenesis of diabetic cardiomyopathy (DCM) and nephropathy (DN), however its epigenetic regulation is still unclear. Interestingly, histone acetylation epigenetically regulates neprilysin expression in Alzheimer's disease.

Objectives: The present study was aimed at delineating role of histone acetylation in regulation of NPS in DCM and DN. Read More

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http://dx.doi.org/10.2174/1874467212666181122092300DOI Listing
January 2019
18 Reads

Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis.

Curr Mol Pharmacol 2019 ;12(1):27-49

School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia.

Background: Mycolic acids (MAs) are the characteristic, integral building blocks for the mycomembrane belonging to the insidious bacterial pathogen Mycobacterium tuberculosis (M.tb). These C60-C90 long α-alkyl-β-hydroxylated fatty acids provide protection to the tubercle bacilli against the outside threats, thus allowing its survival, virulence and resistance to the current antibacterial agents. Read More

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http://dx.doi.org/10.2174/1874467211666181025141114DOI Listing
January 2019
10 Reads

Curcuminoids and Novel Opportunities for the Treatment of Alzheimer's Disease: Which Molecules are Actually Effective?

Curr Mol Pharmacol 2019 ;12(1):12-26

A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, 4 Bogomoletz Street, Kiev 01024, Ukraine.

Background: Millions of people worldwide are suffering from Alzheimer's disease (AD), and there are only symptomatic treatments available for this disease. Thus, there is a great need to identify drugs capable of arresting or reversing AD. Constituents of the spice turmeric, in particular, curcuminoids, seem to be very promising, as evident from in vitro experiments and tests using animal models of AD. Read More

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http://dx.doi.org/10.2174/1874467211666181012150847DOI Listing
January 2019
3 Reads

Pharmacokinetic And Pharmacodynamic Aspects Of Peyote And Mescaline: Clinical And Forensic Repercussions.

Curr Mol Pharmacol 2018 Oct 10. Epub 2018 Oct 10.

IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, Rua Central de Gandra, 1317, 4585-116 Gandra PRD. Portugal.

Background: Mescaline (3,4,5-trimethoxyphenethylamine), mainly found in the Peyote cactus (Lophophora williamsii), is one of the oldest known hallucinogenic agents that influence human and animal behavior, but its psychoactive mechanisms remain poorly understood.

Objectives: This article aims to fully review pharmacokinetics and pharmacodynamics of mescaline, focusing on the in vivo and in vitro metabolic profile of the drug and its implications for the variability of response.

Methods: Mescaline pharmacokinetic and pharmacodynamic aspects were searched in books and in PubMed (U. Read More

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http://www.eurekaselect.com/166140/article
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http://dx.doi.org/10.2174/1874467211666181010154139DOI Listing
October 2018
7 Reads

NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy.

Curr Mol Pharmacol 2019 ;12(1):50-60

Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Background: Radiotherapy is a treatment modality for cancer. For better therapeutic efficiency, it could be used in combination with surgery, chemotherapy or immunotherapy. In addition to its beneficial therapeutic effects, exposure to radiation leads to several toxic effects on normal tissues. Read More

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http://www.eurekaselect.com/166141/article
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http://dx.doi.org/10.2174/1874467211666181010154709DOI Listing
January 2019
11 Reads

Combination Treatment of p53-Null HL-60 cells with Histone Deacetylase Inhibitors and Chlorambucil Augments Apoptosis and Increases BCL6 and p21 Gene Expression.

Curr Mol Pharmacol 2019 ;12(1):72-81

Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria 3053, Australia.

Background: Treatment of hematological malignancies with conventional DNA-damaging drugs, such as chlorambucil (CLB), commonly results in p53-dependent chemo-resistance. Chromatin modifying agents, such as histone deacetylase inhibitors (HDACIs), sodium butyrate (NaBu) and trichostatin A (TSA), may reverse chemo-resistance by modulating the activity of chromatin remodeling enzymes and/or genes that control cell proliferation, differentiation and survival.

Objective: This study examined the potential use of HDACIs and CLB combination therapies in an in vitro chemo-resistant leukemia model. Read More

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http://dx.doi.org/10.2174/1874467211666181010161836DOI Listing
January 2019
3 Reads

The Role of SAPK/JNK Pathway in the Synergistic Effects of Metformin and Dacarbazine on Apoptosis in Raji and Ramos Lymphoma Cells.

Curr Mol Pharmacol 2018 ;11(4):336-342

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Besides the first-line medication for the treatment of type 2 diabetes, the growth inhibitory activity of metformin alone or in combination with conventional chemotherapeutics has been addressed on a panel of cell lines. In this study, we investigated the cytotoxicity and apoptosis of the metformin alone and in combination with dacarbazine in Raji and Ramos lymphoma cell lines.

Methods: Cell viability and apoptosis measured using resazurin assay, flow cytometry of PI stained cells and western blot analysis. Read More

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http://www.eurekaselect.com/165010/article
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http://dx.doi.org/10.2174/1874467211666180830150546DOI Listing
April 2019
13 Reads

The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer.

Curr Mol Pharmacol 2018 ;11(4):326-335

Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Radiation causes damage to irradiated tissues and also tissues that do not receive direct irradiation through a phenomenon called bystander effects. Melatonin as a potent antioxidant and anti-inflammatory agent is known for protection of normal tissues against ionizing irradiation. In addition, some studies have suggested that Melatonin may have some anti-cancer properties. Read More

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http://dx.doi.org/10.2174/1874467211666180830150154DOI Listing
April 2019
12 Reads

Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review.

Curr Mol Pharmacol 2018 ;11(4):270-278

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, IFTM University, Moradabad - 244102, India.

Background: The brain is a vital part of the central nervous system (CNS), characterized by the presence of soft tissue in its internal structure which protects itself. Research on design of drugs for CNS disorders is in progress and up to date information is required for further investigation.

Objective: The present paper is written with the objective to compile all the available data and information on CNS disorders and CNS acting drugs. Read More

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http://www.eurekaselect.com/164815/article
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http://dx.doi.org/10.2174/1874467211666180821101158DOI Listing
April 2019
7 Reads

Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer.

Curr Mol Pharmacol 2018 ;11(4):316-325

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.

Objective: To explore the mechanism by which lobaplatin, as monotherapy and in combination with paclitaxel, inhibits the proliferation of human gastric cancer SGC-7901 cells.

Methods: After treatment, the MTT assay was used to assess cell viability; cell cycle distribution was evaluated flow-cytometrically. Western blot was used to quantitate cyclin D1, E1, B1, and Cdk2/4 protein levels. Read More

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http://dx.doi.org/10.2174/1874467211666180813095050DOI Listing
April 2019
3 Reads

Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?

Curr Mol Pharmacol 2019 ;12(1):2-11

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Melatonin is a natural body product that has shown potent antioxidant property against various toxic agents. For more than two decades, the abilities of melatonin as a potent radioprotector against toxic effects of ionizing radiation (IR) have been proved. However, in the recent years, several studies have been conducted to illustrate how melatonin protects normal cells against IR. Read More

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http://dx.doi.org/10.2174/1874467211666180802164449DOI Listing
January 2019
10 Reads

Sepsis: The Involvement of Platelets and the Current Treatments.

Curr Mol Pharmacol 2018 ;11(4):261-269

Department of Biomedical and Forensic Sciences, Anglia Ruskin University, Cambridge, United Kingdom.

Objective: Sepsis, a serious and life threatening complication arising from infection caused by lipopolysaccharide, is a complex inflammatory syndrome, and one of the main causes of death in intensive care units (ICU). It is characterized as an over-response of pro-coagulant agents promotes coagulopathy and thrombus formation, resulting in disseminated intravascular coagulation (DIC). Furthermore, it can cause multiple organ dysfunction and hypotension (septic shock) resulting in death. Read More

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http://dx.doi.org/10.2174/1874467211666180619124531DOI Listing
April 2019
5 Reads

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters.

Curr Mol Pharmacol 2018 ;11(4):285-304

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Nowadays, ionizing radiations are used for various medical and terroristic aims. These purposes involve exposure to ionizing radiations. Hence, people are at risk for acute or late effects. Read More

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http://dx.doi.org/10.2174/1874467211666180619125653DOI Listing
April 2019
10 Reads

Phagocytosis and Motility in Human Neutrophils is Competent but Compromised by Pharmacological Inhibition of Ezrin Phosphorylation.

Curr Mol Pharmacol 2018 ;11(4):305-315

Neutrophil Signalling Group, Sir Geraint Evans Building, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom.

Background And Objective: Ezrin links the cortical cytoskeleton to the plasma membrane and plays a role in regulating changes in cell shape. Recently, NSC668394 has been shown to inhibit a key step for its activity, i.e. Read More

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http://www.eurekaselect.com/162184/article
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http://dx.doi.org/10.2174/1874467211666180516100613DOI Listing
April 2019
4 Reads

Impact of Sphingolipid Mediators on the Determination of Cochlear Survival in Ototoxicity.

Curr Mol Pharmacol 2018 ;11(4):279-284

Department of Otolaryngology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8576, Japan.

Background And Objective: Sphingolipid metabolites, including ceramide, sphingosine, and their phosphorylates (ceramide-1-phosphonate [C1P] and sphingosine-1-phosphate [S1P]), regulate diverse cellular processes including apoptosis, the cell cycle, and cellular differentiation. Recent studies have shown that these sphingolipid metabolites are generated in response to ototoxic agents and play important roles in determining the fate of cochlear hair cells in ototoxic injury.

Methods: This review summarizes the current knowledge on the roles of sphingolipid mediators in cochlear ototoxicity. Read More

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http://www.eurekaselect.com/162187/article
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http://dx.doi.org/10.2174/1874467211666180516101111DOI Listing
April 2019
6 Reads

Tandem Mass Spectrometric Cell Wall Proteome Profiling of a Candida albicans hwp2 Mutant Strain.

Curr Mol Pharmacol 2018 ;11(3):211-225

Department of Natural Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon.

Background: Candida albicans is present as part of the normal gut flora and detected in the oral cavities and GI tracts of around fifty percent of adults. Benign colonization can turn pathogenic causing a variety of mild to severe infections. In a pathogen, the cell wall and cell surface proteins are major antigenic determinants and drug targets as they are the primary structures that contact the host. Read More

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http://dx.doi.org/10.2174/1874467211666180509153228DOI Listing
December 2018
2 Reads

Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.

Curr Mol Pharmacol 2018 ;11(3):226-236

Department of Chemistry, University of Patras, Patras, 26500, Greece.

Background: The Renin Angiotensin System (RAS) is pharmacologically targeted to reduce blood pressure, and patient compliance to oral medications is a clinical issue. The mechanisms of action of angiotensin receptor blockers (ARBs) in reducing blood pressure are not well understood and are purported to be via a reduction of angiotensin II signaling.

Objective: We aimed to develop a transdermal delivery method for ARBs (losartan potassium and valsartan) and to determine if ARBs reveal a vasodilatory effect of the novel RAS peptide, alamandine. Read More

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http://www.eurekaselect.com/161423/article
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http://dx.doi.org/10.2174/1874467211666180419152036DOI Listing
December 2018
28 Reads

Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.

Curr Mol Pharmacol 2018 ;11(3):191-202

Department of Pharmacology, School of Pharmaceutical and Allied Medical Sciences, CT University, Ferozepur Road, Ludhiana, Punjab, India.

Background: Tyrosine-protein phosphatase is an enzyme that functions in a unit with tyrosine kinases to regulate signaling pathways. Several members of the PTP family link to human disease predisposition such as PTP1B, SH2, DEP1, and inhibition of these enzymes may represent an effective palliative therapy.

Objective: This review aims to summarize the rapidly developing role of the PTPs in various physiological and pathological states. Read More

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http://www.eurekaselect.com/160122/article
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http://dx.doi.org/10.2174/1874467211666180226161846DOI Listing
December 2018
10 Reads

COX-2 in Radiotherapy: A Potential Target for Radioprotection and Radiosensitization.

Curr Mol Pharmacol 2018 ;11(3):173-183

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah, Iran.

Background: Each year, millions of people die from cancer. Radiotherapy is one of the main treatment strategies for cancer patients. Despite the beneficial roles of treatment with radiation, several side effects may threaten normal tissues of patients in the years after treatment. Read More

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http://dx.doi.org/10.2174/1874467211666180219102520DOI Listing
December 2018
20 Reads

L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration.

Curr Mol Pharmacol 2018 ;11(3):237-253

Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.

Background: In age-related macular degeneration, oxidative damage and abnormal neovascularization in the retina are caused by the upregulation of vascular endothelium growth factor and reduced expression of Glutathione-S-transferase genes. Current treatments are only palliative. Compounds from cruciferous vegetables (e. Read More

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http://www.eurekaselect.com/159396/article
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http://dx.doi.org/10.2174/1874467211666180125163009DOI Listing
December 2018
19 Reads

Editorial: Corticotropin Releasing Factor (CRF) and Its Receptors: From Structure to Function in Health and Disease (Part II).

Authors:
George Liapakis

Curr Mol Pharmacol 2018 ;11(1):2-3

Department of Pharmacology School of Medicine University of Crete Voutes, Heraklion 71003. Greece.

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http://dx.doi.org/10.2174/187446721101180103122730DOI Listing
December 2018
4 Reads

Preface.

Authors:
Michael Kahn

Curr Mol Pharmacol 2018 ;11(1)

Beckman Research Institute City of Hope Duarte, CA 91010-3000. United States.

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http://www.eurekaselect.com/158790/article
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http://dx.doi.org/10.2174/187446721101180103122445DOI Listing
December 2018
7 Reads

Targeting M3 Muscarinic Receptors for Colon Cancer Therapy.

Curr Mol Pharmacol 2018 ;11(3):184-190

Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.

Background: Expression and activation of subtype-3 muscarinic receptors (M3R) plays an important role in the progression of colorectal neoplasia.

Method: Herein, we describe the role of muscarinic receptors in colon cancer, focusing specifically on M3R, illustrate how M3R over-expression and activation of post-receptor signaling pathways potentiates tumor progression, and explore the efficacy and safety of a variety of therapeutic approaches that can target the molecules involved.

Results: Colon cancers overexpress M3R mRNA (CHRM3) and protein, and post-M3R signaling stimulates cell proliferation. Read More

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http://dx.doi.org/10.2174/1874467211666180119115828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371400PMC
December 2018
6 Reads

Targeting of Inflammation for Radiation Protection and Mitigation.

Curr Mol Pharmacol 2018 ;11(3):203-210

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah, Iran.

Background: Inflammation is the response of the immune system that guards the body against several harmful stimuli in normal conditions. However, in response to ionizing radiation that leads to a massive cell death and DNA aberrations, this phenomenon causes various side effects in normal tissues. Inflammation is involved in various side effects such as gastrointestinal toxicity, mucositis, skin reactions, nervous system damage, pneumonitis, fibrosis and so on. Read More

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http://dx.doi.org/10.2174/1874467210666171108165641DOI Listing
December 2018
16 Reads

MicroRNAs, Cancer and Diet: Facts and New Exciting Perspectives.

Curr Mol Pharmacol 2018 ;11(2):90-96

Dipartimento di Scienze Motorie e del Benessere, Universita di Napoli Parthenope, Naples, Italy.

Background: MicroRNAs (miRNAs) are small non-coding RNAs able to regulate gene expression at multiple levels. They are detected in tissues, blood, and other body fluids with high stability and have a recognized role in maintaining of tissue homeostasis. Aberrant expression profile of miRNAs has been observed in several diseases, primarily cancer. Read More

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http://www.eurekaselect.com/156380/article
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http://dx.doi.org/10.2174/1874467210666171013123733DOI Listing
January 2019
12 Reads

Editorial: Corticotropin Releasing Factor (CRF) and its Receptors: From Structure to Function in Health and Disease (Part I).

Authors:
George Liapakis

Curr Mol Pharmacol 2017 ;10(4):257-258

Associate Professor of Pharmacology Department of Pharmacology School of Medicine University of Crete Voutes, Heraklion 71003. Greece.

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http://dx.doi.org/10.2174/187446721004171004092955DOI Listing
October 2018
6 Reads

Gamma-Decanolactone Improves Biochemical Parameters Associated with Pilocarpine-Induced Seizures in Male Mice.

Curr Mol Pharmacol 2018 ;11(2):162-169

Laboratory of Neuropharmacology and Preclinical Toxicology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background And Objective: Gamma-decanolactone (GD) is a monoterpene effective against seizures induced by pentylenetetrazole. The mechanism of action of GD is likely to be via glutamate antagonism. GD also inhibits intracellular reactive oxygen species (ROS) generation and the lipopolysaccharide-induced expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in vitro. Read More

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http://dx.doi.org/10.2174/1874467210666171002114954DOI Listing
January 2019
48 Reads

Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists.

Curr Mol Pharmacol 2018 ;11(2):113-121

Center for Molecular Pathways and Drug Discovery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Background And Objective: The development of the tyrosine kinase inhibitor Imatinib (IM) represents a milestone in CML (Chronic Myeloid Leukemia) treatment. However, it is not curative and patients develop IM resistance. IM resistance has been previously correlated with the emergence of drug-resistant LIC/LSC (Leukemia Initiating Cell/Leukemia Stem Cell) and increased nuclear catenin levels and enhanced Wnt signaling. Read More

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http://dx.doi.org/10.2174/1874467210666170919155739DOI Listing
January 2019
47 Reads

MG17, A Novel Triazole Derivative Abrogated Neuroinflammation and Related Neurodegenerative Symptoms in Rodents.

Curr Mol Pharmacol 2018 ;11(2):122-132

Neuropathic Pain Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Telangana, India.

Background And Objective: The objective of present study is to explore multiple effects of the compound MG17 and relate them to achieve better therapeutic potential against neuroinflammation related disorders. We examined whether our compound is acting through regulating neuroinflammatory mediators.

Methods: We have done some preliminary behavioral studies to shortlist the derivatives using rodent models of peripheral nerve injury in our earlier publication and now we extended our screening studies to explore the test compounds efficacy on other related peripheral neurological disorders such as Streptozotocin- induced diabetic peripheral neuropathy (DPN) and methyl mercury (MeHg) induced neurodegeneration in rats. Read More

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http://dx.doi.org/10.2174/1874467210666170919160245DOI Listing
January 2019
38 Reads

Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats.

Curr Mol Pharmacol 2018 ;11(3):254-259

Tehran University of Medical Science, Tehran, Iran.

Introduction: Addiction is a compulsive drug-seeking and drug-taking behavior. Reduction of high-risk behaviors can reduce the burden of addiction in society and can improve the overall prognosis of drug addiction. The aim of this study is to show that reduction of oxidative stress with socialization will reduce occurrence of high-risk behavior during addiction period. Read More

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http://dx.doi.org/10.2174/1874467210666170919161045DOI Listing
December 2018
79 Reads
1 Citation

The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity.

Curr Mol Pharmacol 2018 ;11(2):155-161

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

Background And Objective: Imipenem has played an important role in the treatment of broad-spectrum bacterial infection. However, nephrotoxicity due to imipenem remains an important clinical challenge. The aim of this study is to test the hypothesis stating that N-acetyl-L-cysteine (NAC) and atorvastatin possess a nephroprotective effect against imipenem-induced nephrotoxicity. Read More

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http://dx.doi.org/10.2174/1874467210666170731115928DOI Listing
January 2019
45 Reads

Opioids in the Frame of New Psychoactive Substances Network: A Complex Pharmacological and Toxicological Issue.

Curr Mol Pharmacol 2018 ;11(2):97-108

Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: New psychoactive substances (NPS), often referred to as "legal highs" or "designer drugs", are derivatives and analogues of existing psychoactive drugs that are introduced in the recreational market to circumvent existing legislation on drugs of abuse.

Objective: This systematic review aims to gather the state of the art regarding chemical, molecular pharmacology and toxicological information of opioid class of NPS.

Methods: Chemical, pharmacological, toxicological and clinical effects of opioid class of NPS were searched in books and in PubMed (U. Read More

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http://dx.doi.org/10.2174/1874467210666170704110146DOI Listing
January 2019
15 Reads