1,513 results match your criteria Current Molecular Medicine[Journal]


Gentianella turkestanerum showed protective effects on hepatic injury by modulating the endoplasmic reticulum stress and NF-κB signaling pathway.

Curr Mol Med 2019 Apr 15. Epub 2019 Apr 15.

College of Pharmacy, Xinjiang Medical University, Urumqi 830011. China.

Objective: To investigate the protective effects of Gentianella turkestanerum extraction by butanol (designated as GBA) on hepatic cell line L02 injury induced by carbon tetrachloride (CCl4) and hydrogen peroxide (H2O2).

Methods: L02 cells were incubated with 5 μg/mL, 10 μg/mL, 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL and 100 μg/mL GBA for 24 hours, and then MTT assay was used to screen the cytotoxicity for GBA. Cells were divided into blank control group, CCl4/H2O2 model group, treated by CCl4 (20 mmol/L) or H2O2 (100 μmol/L); silymarin+CCl4/H2O2 group, treated by CCl4 (20 mmol/L) or H2O2 (100 μmol/L) and 5 μg/mL silymarin; GBA+CCl4/H2O2 group, treated by CCl4 (20 mmol/L) or H2O2 (100 μmol/L) and GBA (5 μg/mL, 10 μg/mL and 20 μg/mL). Read More

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http://dx.doi.org/10.2174/1566524019666190415124838DOI Listing
April 2019
1 Read

Occurrence of Interleukin-2 (330 G/T) Promoter Polymorphism in ARV associated hepatotoxicity.

Curr Mol Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Clinical Sciences, National AIDS Research Institute Pune- 411026. India.

Background: IL-2 cytokine is involved in HIV replication and is also known to cause the hepatic injury. Polymorphisms in IL-2 gene is associated with altered interleukin-2 production.

Method: Hence we assessed the prevalence of IL-2-303G/T polymorphism in 165 HIV patients (34 with and 131without hepatotoxicity) and 155 healthy controls using PCR-RFLP method. Read More

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http://dx.doi.org/10.2174/1566524019666190411093451DOI Listing

Association of Vitamin D Gene Polymorphisms and Bone Mineral Density in Healthy young Saudi Females.

Curr Mol Med 2019 Apr 9. Epub 2019 Apr 9.

Medical Biochemistry department , College of Medicine, Taibah University, KSA and Zagazig University. Egypt.

Background: Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology Objectives: To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers of bone turnover, in a healthy Saudi female population, Methods: A cross-sectional study was carried out at Taibah University, Madinah Region, Kingdom of Saudi Arabia. After receiving informed consent, blood samples from 300 subjects were collected to measure calcium, phosphorus, alkaline phosphatase, parathyroid hormone osteocalcin, and 1,25-OHD and perform genetic analysis of SNPs in vitamin D receptors (VDR) rs2228570, rs731236, and rs11568820. Read More

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http://dx.doi.org/10.2174/1566524019666190409122155DOI Listing
April 2019
2 Reads

Axonopathy likely initiates neuropathological processes via a mechanism of axonal leakage in Alzheimer's mouse models.

Curr Mol Med 2019 Apr 5. Epub 2019 Apr 5.

Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan, Hubei. China.

Background: The formation of hyperphosphorylated tau and the production of β-amyloid are thought to be critical steps contributing to the pathological mechanisms in Alzheimer's disease (AD). However, there has been a long-lasting debate over their importance in the onset of AD. Recent studies have demonstrated that axonopathy is considered as an early neuropathological change of AD. Read More

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http://dx.doi.org/10.2174/1566524019666190405174908DOI Listing
April 2019
1 Read

Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel.

Curr Mol Med 2019 Apr 5. Epub 2019 Apr 5.

Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan. China.

SOX15 is a crucial transcription factor involved in the regulation of embryonic development and in the cell fate determination. It is also an important mediator of tumorigenesis in cancer. Here, we sought to explore the expression patterns and biological functions of SOX15 in esophageal squamous cell carcinomas (ESCC). Read More

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http://dx.doi.org/10.2174/1566524019666190405121139DOI Listing
April 2019
1 Read
3.621 Impact Factor

Human Papillomavirus Genome based Detection and Typing: A Holistic Molecular Approach.

Curr Mol Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005. India.

Human Papillomavirus (HPV) is a species specific double-stranded DNA virus infecting human cutaneous or mucosal tissues. The genome structure of HPV is extremely polymorphic hence making it difficult to discriminate between them. HPV exhibits numerous dissimilar types that can be subdivided into high-risk (HR), probably high-risk and low-risk (LR), causing numerous types of cancers and warts around the genital organs in humans. Read More

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http://dx.doi.org/10.2174/1566524019666190405120441DOI Listing

Serum IL-33 level and IL-33, IL1RL1 gene polymorphisms in asthma and multiple sclerosis patients.

Curr Mol Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan. Iran.

Background: Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Against this background, IL-33 and IL1RL1 play a critical part in autoimmune and inflammatory disorders. Read More

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http://dx.doi.org/10.2174/1566524019666190405120137DOI Listing
April 2019
1 Read

FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium.

Curr Mol Med 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, Chongqing University. China.

Background: In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to associate with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Read More

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http://dx.doi.org/10.2174/1566524019666190405115420DOI Listing
April 2019
1 Read

Assessment of the effect of baicalin on duck virus hepatitis.

Curr Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Institute of Traditional Chinese Veterinary Medicine and MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095. China.

Background: Duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1) is a malignant disease in ducklings, causing economic losses in the duck industry. However, there is still no antiviral drug against DHAV-1 in the clinic.

Objective: Our aim is to investigate the anti-DHAV-1 effect of baicalin, which is a flavonoid derived from the Chinese medicinal herb huang qin (Scutellaria baicalensis Georgi). Read More

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http://dx.doi.org/10.2174/1566524019666190405095301DOI Listing
April 2019
1 Read

Revealing synergistic mechanism of multiple components in compound Fengshiding capsule for rheumatoid arthritis therapeutics by network pharmacology.

Curr Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000. China.

Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet. Read More

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http://dx.doi.org/10.2174/1566524019666190405094125DOI Listing
April 2019
3 Reads
3.621 Impact Factor

Intricate Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Isoforms in Normal Physiology and Disease.

Curr Mol Med 2019 Apr 4. Epub 2019 Apr 4.

School of Life Sciences, Manipal Academy of Higher Education, Manipal - 576104. India.

Background: The phosphoenolpyruvate carboxykinase (PEPCK) isoforms are considered as rate limiting enzymes for gluconeogenesis and glyceroneogenesis pathways. PEPCK exhibits several interesting features such as a) organelle-specific isoforms (cytosolic and a mitochondrial) in vertebrate clade, b) tissue-specific expression of isoforms and c) organism-specific requirement of ATP or GTP as a cofactor. In higher organisms, PEPCK isoforms are intricately regulated and activated through several physiological and pathological stimuli such as corticoids, hormones, nutrient starvation and hypoxia. Read More

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http://dx.doi.org/10.2174/1566524019666190404155801DOI Listing
April 2019
1 Read
3.621 Impact Factor

Molecular chaperone HSP70 and key regulators of apoptosis.

Curr Mol Med 2019 03 25. Epub 2019 Mar 25.

Department of Biostatistics, Beirut Arab University, Lebanon

Identified as a molecular chaperone constitutively being synthesized due to enhanced elevated temperature change, this heat shock protein HSP70 has shown to be intimately involved in many protein biogenesis, facilitating the synthesis and folding of proteins and trafficking of nascent peptides during cell growth. HSP70 also plays a vital role in protein assembly, regulation and interaction with a wide variety of proteins. Stress-induced cell death is under the control of the Bcl-2 family of apoptotic regulators and display either pro-apoptotic or anti-apoptotic activities. Read More

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http://dx.doi.org/10.2174/1566524019666190326114720DOI Listing

Identifying the potential substrates of the depalmitoylation enzyme Acyl-protein thioesterase 1.

Curr Mol Med 2019 Mar 25. Epub 2019 Mar 25.

Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang. China.

Background: The homeostasis of palmitoylation and depalmitoylation is involved in various cellular processes, the disruption of which induced severe physiological consequences. Acyl-protein thioesterase (APT) and palmitoyl-protein thioesterases (PPT) catalyze the depalmitoylation process. The natural mutation in human PPT1 caused neurodegenerative disease, yet the understanding of APT1 remains to be elucidated. Read More

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http://dx.doi.org/10.2174/1566524019666190325143412DOI Listing
March 2019
7 Reads

A Revolution in Reprogramming: Small Molecules.

Authors:
Jin Zhou Jie Sun

Curr Mol Med 2019 Mar 24. Epub 2019 Mar 24.

Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai. China.

Transplantation of reprogrammed cells from accessible sources and in vivo reprogramming are potential therapies for regenerative medicine. During the last decade, genetic approaches, which mostly involved transcription factors and microRNAs, have been shown to affect cell fates. However, their potential carcinogenicity and other unexpected effects limit their translation into clinical applications. Read More

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http://dx.doi.org/10.2174/1566524019666190325113945DOI Listing

Attenuation of cardiac ischaemia-reperfusion injury by treatment with hydrogen-rich water.

Curr Mol Med 2019 Mar 20. Epub 2019 Mar 20.

School of Medicine, Hebei University, Baoding 071000. China.

Hydrogen has been shown to exert a bioactive effect on myocardium. This study examined the signalling pathways for hydrogen attenuating ischaemia-reperfusion injury. In total, 20 male Wistar rats were evaluated for the effects of hydrogen-rich water on ischaemia-reperfusion in hearts. Read More

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http://dx.doi.org/10.2174/1566524019666190321113544DOI Listing
March 2019
1 Read

Integrons and antiseptic resistance genes mediate resistance of Acinetobacter baumannii and Pseudomonas aeruginosa isolates from intensive care unit patients with wound infections.

Curr Mol Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Biological Sciences, College of Arts and Sciences, University of South Florida St. Petersburg, St. Petersburg, Florida. United States.

Acinetobacter baumannii and Pseudomonas aeruginosa are of major concern for hospitalized patients. We evaluated antibiotic and antiseptic resistance of A. baumannii (n = 29) and P. Read More

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http://dx.doi.org/10.2174/1566524019666190321113008DOI Listing

Berberine alleviates amyloid-beta pathogenesis via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice.

Curr Mol Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Pathology, Chongqing Medical University, Chongqing, 400010, Chongqing. China.

Background: Liver kinase B1 (Background: LKB1)/5'-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer's disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine (BBR) activates LKB1/AMPK signaling and ameliorates Aβ pathology. Read More

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http://dx.doi.org/10.2174/1566524019666190315164120DOI Listing
March 2019
3.621 Impact Factor

Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles.

Curr Mol Med 2019 Mar 14. Epub 2019 Mar 14.

Laboratory of Molecular Medicine, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk. Russian Federation.

Background: Considering exosomes as intercellular transporters, thus inevitably interacting with plasma membrane and large available surface of blood cells, we wonder if a fraction of circulating exosomes is associated with the surface of blood cells.

Objective: The aim of this study was to develop an efficient protocol for isolating exosomes associated with the surface of blood cells and to further investigate the characteristics of this fraction in healthy state and during the development of breast cancer, as well as its possible implication for use in diagnostic applications.

Methods: Blood samples were collected from healthy females (HFs) and breast cancer patients (BCPs). Read More

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http://dx.doi.org/10.2174/1566524019666190314120532DOI Listing

Bone Metabolism Markers in Thalassemia Major-Induced Osteoporosis: Results from a Cross-Sectional Observational Study.

Curr Mol Med 2019 Mar 13. Epub 2019 Mar 13.

Hematology/Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias, 11527, Goudi, Athens. Greece.

Background: Thalassemia major (TM) patients eventually face many new health conditions, including endocrinopathies and low bone mineral density, usually observed in the aging general population.

Objective: The aim of the current study was to evaluate biomarkers of bone remodeling in TM patients and to compare them with both osteoporotic and healthy population, in order to investigate new therapeutic paths.

Method: Sixty-four patients with TM (32 men and 32 women) participated in the study. Read More

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http://dx.doi.org/10.2174/1566524019666190314114447DOI Listing
March 2019
1 Read

Diagnostic Value of MiR-125b as a Potential Biomarker for Stage I Lung Adenocarcinoma Lung Adenocarcinoma.

Curr Mol Med 2019 Mar 13. Epub 2019 Mar 13.

Mersin University, School of Medicine, Department of Medical Biology, Mersin . Turkey.

Background: We aimed to explore biological functions of differentially expressed miRNAs during carcinogenesis, to identify miRNAs dysegulations involved in DNA repair mechanisms, and to evaluate potential of miRNAs as prognostic and diagnostic biomarkers for early lung adenocarcinomas (LAC).

Methods: We obtained 21 LAC and paired adjacent normal formalin-fixed, paraffin-embedded lung tissues from patients who underwent curative resection for stage I LAC. We compared expression levels of eight miRNAs involved in DNA repair mechanism between LAC and adjacent tissues. Read More

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http://dx.doi.org/10.2174/1566524019666190314113800DOI Listing
March 2019
2 Reads

Adeno-associated virus 9-mediated small RNA interference of TLR4 alleviates myocardial ischemia and reperfusion injury by inhibition of the NF-κB and MAPK signaling pathways in rats.

Curr Mol Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin. China.

Background Despite intensive investigation, effective therapeutic procedures for myocardial I/R injury are still in demand.

Objective: To explore the effect of adeno-associated virus 9 (AAV9)-mediated small interfering RNA targeting TLR4 in the treatment of myocardial ischemia and reperfusion (I/R) injury and its influence on the NF-κB and MAPK signaling pathways.

Method: Rats were divided into 3 groups, namely, the sham, AAV9-siRNA control, and AAV9-TLR4 siRNA groups. Read More

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http://dx.doi.org/10.2174/1566524019666190311122521DOI Listing
March 2019
1 Read

Glucose Oxidase- and UVA-Induced Changes in the Expression Patterns of Seven De-sumoylation Enzymes (SENPs) Are Associated with Cataract Development.

Curr Mol Med 2019 Mar 10. Epub 2019 Mar 10.

Key Laboratory of Protein Chemistry and Developmental Biology, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081. China.

Purpose: It has been well established that sumoylation acts as an important regulatory mechanism that controls many different cellular processes. In the eye, we and others have shown that sumoylation plays an indispensable role during mouse eye development. Whether sumoylation is implicated in ocular pathogenesis remains to be further studied. Read More

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http://dx.doi.org/10.2174/1566524019666190311094313DOI Listing

The Prognostic and Clinicopathologic Characteristics of OCT4 and Lung Cancer: a Meta-Analysis.

Curr Mol Med 2019 Mar 8. Epub 2019 Mar 8.

Reproductive Department, Xiangya Hospital, Central South University, Changsha. China.

Objective: The relationship between OCT4 and clinicopathological features in lung cancer is controversial from the recently publications. Therefore, we conducted this meta-analysis to quantitatively investigate the prognostic and clinicopathologic characteristics of OCT4 in lung cancer.

Methods: A comprehensive literature search of the PubMed, EMBASE, Cochrane Library, WOS, CNKI and Wanfang databases was performed to identify studies. Read More

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http://dx.doi.org/10.2174/1566524019666190308163315DOI Listing
March 2019
2 Reads

Knockdown of Kinase family 15 inhibits cancer cell proliferation in vitro and its Clinical relevance in Triple-Negative Breast Cancer.

Curr Mol Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai. China.

Purpose: Breast cancer is the most prevalent malignancy and the leading cause of death among women. Triple-negative breast cancer (TNBC) is a subtype of breast cancer and shows a distinctly aggressive nature with higher rates of relapse and shorter overall survival in the metastatic setting compared to other subtypes of breast cancer. This study aimed to assess the effect of KIF15 on various clinicopathological characteristics, survival analysis, and cell proliferation in triple-negative breast cancer, which has not been reported to our knowledge. Read More

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http://dx.doi.org/10.2174/1566524019666190308122108DOI Listing

The Mitochondrial tRNAHis G12192A Mutation May Modulate the Clinical Expression of Deafness-Associated tRNAThr G15927A Mutation in a Chinese Pedigree.

Curr Mol Med 2019 Mar 8. Epub 2019 Mar 8.

Central Laboratory, Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Hangzhou. China.

Background: Mutations in mitochondrial tRNA (mt-tRNA) genes have been found to be associated with both syndromic and non-syndromic hearing impairment. However, the pathophysiology underlying mt-tRNA mutations in clinical expression of hearing loss remains poorly understood.

Objective: The aim of this study was to explore the potential association between mt-tRNA mutations and hearing loss. Read More

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http://dx.doi.org/10.2174/1566524019666190308121552DOI Listing

Negative correlation between serum levels of homocysteine and apolipoprotein M.

Curr Mol Med 2019 Mar 7. Epub 2019 Mar 7.

Department of Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou 213003. China.

Background: Homocysteine (Hcy) has been suggested as an independent risk factor for atherosclerosis. Apolipoprotein M (apoM) is a constituent of the HDL particles. The goal of this study was to examine the serum levels of homocysteine and apoM and to determine whether homocysteine influences apoM synthesis. Read More

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http://dx.doi.org/10.2174/1566524019666190308115624DOI Listing

Novel GLI3 mutations in Chinese patients with non-syndromic post-axial polydactyly.

Curr Mol Med 2019 Mar 7. Epub 2019 Mar 7.

Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha. China.

Background: Polydactyly, characterized by supernumerary digits in the upper or lower extremities, is the most common congenital digital abnormalities. It derives from the defective patterning of anteroposterior axis of the developing limb, with various etiology and clinical heterogeneity. The patients with post-axial polydactyly type A (PAPA) have the typical symptom of a well-formed supernumerary digit outside the fifth digit. Read More

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http://dx.doi.org/10.2174/1566524019666190308110122DOI Listing

Stew in its own juice: Protein homeostasis machinery inhibition reduces cell viability in multiple myeloma cell lines.

Curr Mol Med 2019 Mar 5. Epub 2019 Mar 5.

Clinical and Experimental Oncology Department, Universidade Federal de São Paulo, UNIFESP. Brazil.

Multiple myeloma (MM) cells accumulate in the bone marrow and produce enormous quantities of immunoglobulins, causing endoplasmatic reticulum stress and activation of protein handling machinery, such as heat shock protein response, autophagy and unfolded protein response (UPR). We evaluated cell lines viability after treatment with bortezomib (B) in combination with HSP70 (VER-15508) and autophagy (SBI-0206965) or UPR (STF-083010) inhibitors. For RPMI-8226, after 72 hours of treatment with B+VER+STF or B+VER+SBI, we observed 15% of viable cells, but treatment with B alone was better (90% of cell death). Read More

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http://dx.doi.org/10.2174/1566524019666190305134441DOI Listing
March 2019
5 Reads

Association of ATG7 Polymorphisms and Clear Cell Renal Cell Carcinoma Risk.

Curr Mol Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004,. China.

Background: Kidney cancer is one of the most common cancers worldwide. Recent studies have suggested that single nucleotide polymorphisms (SNPs) in autophagy-related gene are associated with the risk of kidney cancer.

Objective: This study was undertaken to investigate the association of autophagy-related gene 7 (ATG7) polymorphisms with the risk of clear cell renal cell carcinoma (ccRCC) in the Chinese Han population. Read More

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http://dx.doi.org/10.2174/1566524019666190227202003DOI Listing
February 2019

Treatment with Radix Euphorbiae Ebracteolatae significantly decreases the expression of E6 and L1, and increases the expression of p53 and Rb in HPV18-infected human foreskin keratinocytes.

Curr Mol Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Dermatology, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, 528 Zhang Heng Road, Pudong New Area District, Shanghai 201203. China.

Background: Radix Euphorbiae Ebracteolatae (REE) was recently reported to be significantly superior to vitamin A acid ointment in treating multiple plantar warts. However, effects of REE on HPV18 remain unclear. Therefore, the current study aimed to investigate effects of REE on the proliferation of HPV18, and explore possible molecular mechanisms underlying the effects. Read More

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http://dx.doi.org/10.2174/1566524019666190226102713DOI Listing
February 2019
1 Read
3.621 Impact Factor

Chemotherapy resistance molecular mechanism in small cell lung cancer.

Curr Mol Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

The malignancy of small cell lung cancer (SCLC) is the highest of all lung cancer types. It is characterized by rapid growth, early occurrence of distant sites metastasis, poor survival rates and initially sensitive to chemotherapy and radiotherapy. However, most patients eventually relapse or disease progression because of chemotherapy resistance. Read More

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http://dx.doi.org/10.2174/1566524019666190226104909DOI Listing
February 2019
3.621 Impact Factor

Investigation of Adsorption Tyrphostin AG528 anticancer drug upon the CNT(6,6-6) nanotube: A DFT study.

Curr Mol Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Chemistry, Ferdowsi University of Mashhad, Mashhad. Iran.

In the present study, the interaction between drug Tyrphostin AG528 and CNT(6,6-6) nanotube by Density Functional Theory (DFT) calculations in an solvent water has been investigated for the first time. According to the calculations, intermolecular hydrogen bonds take place between active position of the molecule Tyrphostin AG528 and hydrogen atoms of the nanotube which plays an important role in the stability of complex CNT(6,6-6)/Tyrphostin AG528. The non-bonded interaction effects of the molecule Tyrphostin AG528 with CNT(6,6-6) nanotube on the electronic properties, chemical shift tensors and natural charge have been also detected. Read More

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http://dx.doi.org/10.2174/1566524019666190226111823DOI Listing
February 2019

Diagnostic Value of Non-Invasive Prenatal Screening of Β-Thalassemia by Cell Free Fetal DNA and Fetal NRBC.

Curr Mol Med 2019 Feb 26. Epub 2019 Feb 26.

Medical biochemistry, Tarbiat Modares University. Iran.

Background: Beta thalassemia is a common disorder with autosomal recessive inheritance. The most reliable diagnostic method is invasive techniques have the risk of miscarriage. Now the non-invasive methods will be gradually alternative for these invasive techniques. Read More

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http://dx.doi.org/10.2174/1566524019666190226124135DOI Listing
February 2019
7 Reads

Impact of Active Antihyperglycemic Components as herbal therapy for Preventive Health Care Management of Diabetes.

Curr Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan. India.

Diabetes is a metabolic hyperglycemic condition that progressively develops, effect small and large sensory fibers in affected population. It has various complications as hypertension, coronary artery disease, stroke, blindness, kidney disease as well as peripheral neuropathy. Sulfonylureas, thiazolidinediones, metformin, biguanidine, acarbose and insulin are commonly used drugs by diabetic patients, but these all have certain side effects. Read More

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http://dx.doi.org/10.2174/1566524019666190219124301DOI Listing
February 2019
6 Reads

The genetic variants of IKZF1 gene linked with the growing risk of childhood acute lymphoblastic leukaemia.

Curr Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Pediatric Medicine Departments, Faculty of Medicine, Menoufia University. Egypt.

Background: The zinc finger protein IKAROS (IKZF1) is an essential transcription factor in haematopoiesis that is involved primarily in lymphoid tissue differentiation. Many studies have indicated that IKZF1 alterations may be associated with acute lymphoblastic leukaemia, but the results remain controversial.

Objective: We aimed to investigate the association of the rs4132601 T/G and rs10272724 T/C IKZF1 gene polymorphisms with the risk of childhood acute lymphoblastic leukaemia and to determine whether these genetic variants affect the clinical parameters and the iron profiles of these children cohort. Read More

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http://dx.doi.org/10.2174/1566524019666190219123900DOI Listing
February 2019
5 Reads

Sumoylation Plays Fundamental Roles During Eye Development and Pathogenesis.

Curr Mol Med 2018 ;18(8):507-508

One-Hundred Talent Professor of Ophthalmology Section Director, Eye Development & Molecular Pathogenesis The State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University, China.

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http://dx.doi.org/10.2174/156652401808190130160225DOI Listing
January 2018

Potential Mutations in Chinese Pathologic Myopic Patients and Contributions to Phenotype.

Curr Mol Med 2018 ;18(10):689-697

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: Pathologic myopia is a leading cause of visual impairment in East Asia. The aim of this study was to investigate the potential mutations in Chinese pathologic myopic patients and to analyze the correlations between genotype and clinical phenotype.

Methods: One hundred and three patients with pathologic myopia and one hundred and nine unrelated healthy controls were recruited from Zhongshan Ophthalmic Center. Read More

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http://dx.doi.org/10.2174/1566524019666190211120016DOI Listing
January 2018
10 Reads

Estriol Inhibits Dermcidin Isoform-2 Induced Inflammatory Cytokine Expression Via Nitric Oxide Synthesis in Human Neutrophil.

Curr Mol Med 2018 ;18(10):672-678

Post Graduate Department of Biochemistry, Cell & Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Rangamati, Midnapore, WB, 721102, India.

Background: An increase in the level of cytokines like TNF-α and IL-6 causes the inflammatory surge in acute ischemic heart disease (AIHD).

Objective: A high-level dermcidin isoform-2 (DCN-2) occurrence in AIHD was subjected to determine a possible regulation of cytokines expression. The effect of estrogen to counteract the inflammatory response was determined. Read More

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http://dx.doi.org/10.2174/1566524019666190208095754DOI Listing
January 2018
4 Reads

Histone Deacetylase Inhibition Attenuates Cardiomyocyte Hypoxia-Reoxygenation Injury.

Curr Mol Med 2018 ;18(10):711-718

Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan, United States.

Background: Cardiac reperfusion injury can have devastating consequences. Histone deacetylase (HDAC) inhibitors are potent cytoprotective agents, but their role in the prevention of cardiac injury remains ill-defined.

Objective: We sought to determine the therapeutic potential of HDAC inhibitors in an in vitro model of cardiomyocyte hypoxia-reoxygenation (H/R). Read More

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http://dx.doi.org/10.2174/1566524019666190208102729DOI Listing
January 2018

Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway.

Curr Mol Med 2018 ;18(10):698-710

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Backgrounds: We recently reported that Naoxintong (NXT), a China Food and Drug Administration (FDA)-approved cardiac medicine, could reduce the plaque size, but the underlying mechanism remains elusive now.

Objective: In this study, we investigated the effects of NXT on foam cell accumulation both in vivo and in vitro and explored related mechanisms.

Method: THP-1 cells and bone marrow-derived macrophages were incubated with oxidized low-density lipoprotein (ox-LDL) with/without Naoxintong. Read More

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http://dx.doi.org/10.2174/1566524019666190207143207DOI Listing
January 2018
1 Read

Human Disease Modelling Techniques: Current Progress.

Curr Mol Med 2018 ;18(10):655-660

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russian Federation.

Advances in genetic engineering and genomic studies facilitated the development of animal models of human diseases. To date, numerous models based on different animal species are available for the most socially significant human diseases, such as cardiovascular disorders, cancer, neurodegenerative and metabolic disorders. Modern genetic methods allow creating animals with certain genes up- or downregulated, as well as bearing specific mutations. Read More

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http://dx.doi.org/10.2174/1566524019666190206204357DOI Listing
January 2018
4 Reads

GDF11 Attenuated ANG II-Induced Hypertrophic Cardiomyopathy and Expression of ANP, BNP and Beta-MHC Through Down- Regulating CCL11 in Mice.

Curr Mol Med 2018 ;18(10):661-671

Department of Cardiology, Gong Li Hospital, 219 Miao Pu Road, Pu Dong New Area, Shanghai 200135, China.

Background: Growth differentiation factor 11 (GDF11) decreases with age, and increased C-C motif chemokine 11 (CCL11) is involved in aging. However, the effects of GDF11 on Angiotensin II (ANG II)-induced hypertrophic cardiomyopathy and expression of markers for volume overload and hypertrophy such as ANP, BNP and beta-MHC, as well as the relationship between GDF11 and CCL11 in hypertrophic cardiomyopathy are unclear. Therefore, the current study aimed to examine the effects of GDF11 on ANG II-induced hypertrophic cardiomyopathy and expression of ANP, BNP and beta-MHC in mice, and explore possible molecular mechanisms. Read More

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http://dx.doi.org/10.2174/1566524019666190204112753DOI Listing
January 2018
11 Reads

New approach for cancer immunotherapy based on the cancer stem cell antigens properties.

Curr Mol Med 2019 Feb 3. Epub 2019 Feb 3.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz. Iran.

Background: Cancer stem cells (CSCs) are a rare population of tumor cells, which play an important role in tumor initiation, progression, and maintenance. The concept that cancer cells arise from stem cells was presented about 150 years ago. Nowadays, because of the heterogeneity of tumor cells, this hypothesis has been renewed. Read More

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http://www.eurekaselect.com/169602/article
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http://dx.doi.org/10.2174/1566524019666190204114721DOI Listing
February 2019
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Th1/Th17 Cytokine Profile is Induced by Macrophage Migration Inhibitory Factor in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.

Curr Mol Med 2018 ;18(10):679-688

Instituto de Investigacion en Ciencias Biomedicas, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.

Background: Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine that plays a crucial role as a regulator of the innate and adaptive immune responses and takes part in the destructive process of the joint in rheumatoid arthritis (RA) by promoting angiogenesis and inducing proinflammatory cytokines and matrix metalloproteinases (MMP). We evaluated if recombinant human MIF (rhMIF) induces the production of TNF-α, IFN-γ, IL-1β, IL-6, IL-10, IL-17A, and IL- 17F in peripheral blood mononuclear cells (PBMC) from RA patients and control subjects (CS).

Methods: The PBMC from RA patients and CS were stimulated for 24 hours with combinations of LPS, rhMIF or the MIF antagonist ISO-1. Read More

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http://dx.doi.org/10.2174/1566524019666190129123240DOI Listing
January 2018
1 Read
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Small Incision Femtosecond Laser-assisted X-ray-irradiated Corneal Intrastromal Xenotransplantation in Rhesus Monkeys: A Preliminary Study.

Curr Mol Med 2018 ;18(9):612-621

Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University. Guangzhou 510060, China.

Background: Gamma-ray irradiation could significantly induce widespread apoptosis in corneas and reduced the allogenicity of donor cornea. And the X-rays may have similar biological effects. The feasibility and effects of X-ray-irradiated corneal lamellae have not been assessed yet. Read More

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http://dx.doi.org/10.2174/1566524019666190129123935DOI Listing
January 2018
1 Read

The Bromodomain and Extra-Terminal Protein Inhibitor OTX015 Suppresses T Helper Cell Proliferation and Differentiation.

Curr Mol Med 2018 ;18(9):594-601

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.

Background: Dynamic epigenetic alterations accompanying CD4+ T helper cell differentiation have been implicated in multiple autoimmune diseases. The bromodomain and extra-terminal (BET) proteins are epigenetic regulators that recognize and bind to acetylated histones in chromatin and are targets for pharmacological inhibition. In this study we tested a new BET inhibitor under clinical development, OTX015, to interrogate its effects on key CD4+ T cell subsets associated with autoimmunity. Read More

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http://dx.doi.org/10.2174/1566524019666190126112238DOI Listing
January 2018
2 Reads

Localization Patterns of Sumoylation Enzymes E1, E2 and E3 in Ocular Cell Lines Predict Their Functional Importance.

Curr Mol Med 2018 ;18(8):516-522

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #7 Jinsui Road, Guangzhou, Guangdong 510230, China.

Purpose: It is well established now that protein sumoylation acts as an important regulatory mechanism mediating control of ocular development through regulation of multiple transcription factors. Yet the functional mechanisms of each factor modulated remain to be further explored using the available in vitro systems. In this regard, various ocular cell lines including HLE, FHL124, αTN4-1, N/N1003A and ARPE-19 have been demonstrated to be useful for biochemical and molecular analyses of normal physiology and pathogenesis. Read More

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http://dx.doi.org/10.2174/1566524019666190112144436DOI Listing
January 2018
2 Reads

Analysis of the Differential Expression Patterns of Sumoylation Enzymes E1, E2 and E3 in Ocular Cell Lines.

Curr Mol Med 2018 ;18(8):509-515

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #7 Jinsui Road, Guangzhou, Guangdong 510230, China.

Purpose: Protein sumoylation is a well established regulatory mechanism to control many cellular processes such as chromatin structure dynamics, transcriptional regulation of gene expression, cell proliferation and differentiation, cell transformation and carcinogenesis, autophagy and senescence. In the vertebrate vision system, we and others have revealed that sumoylation plays important roles in regulating differentiation of several ocular tissues during eye development. To further elucidate the functional mechanisms of sumoylation, in vitro assay systems are needed. Read More

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http://dx.doi.org/10.2174/1566524019666190112143636DOI Listing
January 2018
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Localization Analysis of Seven De-sumoylation Enzymes (SENPs) in Ocular Cell Lines.

Curr Mol Med 2018 ;18(8):523-532

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #7 Jinsui Road, Guangzhou, Guangdong 510230, China.

Purpose: It is now well established that protein sumoylation acts as an important regulatory mechanism modulating functions over three thousand proteins. In the vision system, protein conjugation with SUMO peptides can regulate differentiation of multiple ocular tissues. Such regulation is often explored through analysis of biochemical and physiological changes with various cell lines in vitro. Read More

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http://dx.doi.org/10.2174/1566524019666190112142025DOI Listing
January 2018
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Comparative Analysis of the Interphotoreceptor Retinoid Binding ProteinInduced Models of Experimental Autoimmune Uveitis in B10.RIII versus C57BL/6 Mice.

Curr Mol Med 2018 ;18(9):602-611

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University (SYSU), Guangzhou, 510060, China.

Objective: Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans, among which B10.RIII and C57BL/6 are the frequently used strains in mice, but to date, no study has been reported to compare EAU disease between the two strains. Here we compared the differences in morphology, pathology, visual function of the retinal inflammation and Th1/Th17 immune responses in the EAU models induced by the interphotoreceptor retinoid binding protein (IRBP) between the B10. Read More

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http://dx.doi.org/10.2174/1566524019666190112132610DOI Listing
January 2018
2 Reads