5,766 results match your criteria Current Medicinal Chemistry[Journal]


Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis.

Curr Med Chem 2018 Dec 17. Epub 2018 Dec 17.

Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201. China.

Osteoarthritis (OA) is an age-related degenerative disease, which is characterized by the chronic joint pain, inflammation and the damage of joint cartilage. At present, steroidal drugs and nonsteroidal anti-inflammatory drugs (NSAIDS), selective cyclooxygenase-2 (COX-2) inhibitors, are the first-line drugs for the treatment of OA. However, these drugs could lead to some cardiovascular side effects. Read More

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http://dx.doi.org/10.2174/0929867326666181217153118DOI Listing
December 2018

Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structures.

Curr Med Chem 2018 Dec 17. Epub 2018 Dec 17.

Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka. Japan.

In mammals, catabolism of the heme group is indispensable for life. Heme is first cleaved by the enzyme heme oxygenase (HO) to the linear tetrapyrrole biliverdin IXα (BV), and BV is then converted to bilirubin by biliverdin reductase (BVR). HO utilizes three oxygen molecules (O2) and seven electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR) to open the heme ring and BVR reduces BV through the use of NAD(P)H. Read More

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http://dx.doi.org/10.2174/0929867326666181217142715DOI Listing
December 2018

Unlocking the potential of HK2 in cancer metabolism and therapeutics.

Curr Med Chem 2018 Dec 12. Epub 2018 Dec 12.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa. Portugal.

Glycolysis is a tightly regulated process in which several enzymes, such as hexokinases (HKs), play crucial roles. Cancer cells are characterized by specific expression levels of several isoenzymes in different metabolic pathways and these fea-tures offer possibilities for therapeutic interventions. Overexpression of HKs (mostly of the HK2 isoform) has been con-sistently reported in numerous types of cancer. Read More

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http://dx.doi.org/10.2174/0929867326666181213092652DOI Listing
December 2018

The potential of fucose-containing sulfated polysaccharides as scaffolds for biomedical applications.

Curr Med Chem 2018 Dec 12. Epub 2018 Dec 12.

University of Aveiro - QOPNA, Department of Chemistry Aveiro. Portugal.

Marine environments have a high quantity and diversity of sulfated polysaccharides. In coastal regions brown algae are the most abundant biomass producers and their cell walls have fucose-containing sulfated polysaccharides (FCSP), known as fucans and/or fucoidans. These sulfated compounds have been widely researched for their biomedical properties, namely the immunomodulatory, haemostasis, pathogen inhibition, anti-inflammatory capacity, and antitumoral. Read More

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http://dx.doi.org/10.2174/0929867326666181213093718DOI Listing
December 2018

Nanocrystals as effective delivery systems of poorly water soluble natural molecules.

Curr Med Chem 2018 Dec 12. Epub 2018 Dec 12.

Dept. Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, via Ospedale 72, 09124 Cagliari. Italy.

Natural products are an important source of therapeutically effective compounds throughout the world. Since ancient times, a huge amount of both plant extracts and isolated compoundshave been largely employed in treatment and prevention of human disordersand, currently, more than 60% of the world's population trusts on plant medicamentsas demonstrated by the increasing quantityof herbal therapeutics in the market. Unfortunately, several promising natural molecules for the treatment of the most diverse ailments are characterized by extremely unfavourable features, such as low water solubility and poor/irregular bioavailability, which hinder their clinical use. Read More

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http://dx.doi.org/10.2174/0929867326666181213095809DOI Listing
December 2018

Nitric Oxide in Life and Death of Neutrophils.

Curr Med Chem 2018 Dec 12. Epub 2018 Dec 12.

Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow 119234`. Russian Federation.

Background: Nitric oxide (NO) is a key signalling molecule that has an important role in inflammation. It can be secreted by endothelial cells, neutrophils, and other cells, and once in circulation, NO plays important roles in regulating various neutrophil cellular activities and fate.

Objective: To describe neutrophil cellular responses influenced by NO and its concomitant compound peroxynitrite and signalling mechanisms for neutrophil apoptosis. Read More

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http://dx.doi.org/10.2174/0929867326666181213093152DOI Listing
December 2018

Mechanistic insights of soluble uric acid-related kidney disease.

Curr Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041. China.

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Read More

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http://dx.doi.org/10.2174/0929867326666181211094421DOI Listing
December 2018

Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875. China.

Ruthenium complexes have stood out by several mononuclear complexes which have entered into clinical trials, such as imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) and ([Ru(II)(4,4'-dimethyl-2, '-bipyridine)2-(2(2 '-,2 ' ':5 ' ',2 ' ' ' - terthiophene)-imidazo[4,5-f][1,10]phenanthroline)]2+) (TLD-1433), opening a new avenue for developing promising ruthenium-based anticancer drugs alternative to Cisplatin. Polynuclear ruthenium complexes were reported to exhibit synergistic and/or complementary effects: the enhanced DNA structural recognition and DNA binding as well as in vitro anticancer activities. This review overviews some representative polynuclear ruthenium complexes acting as DNA structural probes, DNA binders and in vitro anticancer agents, which were developed during last decades. Read More

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http://dx.doi.org/10.2174/0929867326666181203143422DOI Listing
December 2018
1 Read

Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology VU University Medical Center De Boelelaan 1118, 1081 HV Amsterdam. Netherlands.

Background: Inherent or acquired chemo resistance in cancer patients has been a perpetual limitation in cancer treatment. Expanding knowledge on essential cellular processes opens a new window for therapeutic targeting. Ribosome biogenesis is a process that shows potential due to its fundamental role in cell development and contribution to tumorigenesis as a result of its upregulation. Read More

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http://dx.doi.org/10.2174/0929867326666181203133332DOI Listing
December 2018
1 Read

Tansition Metal-Based Prodrugs for Anticancer Drug Delivery.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa. Av. Rovisco Pais, 1049-001 Lisboa. Portugal.

Transition metal complexes, of which the platinum(II) cisplatin complex is an example, have been used in medicine to treat cancer for more than 40 years. Although many successes have been achieved, there are problems associated with the use of these drugs, such as side effects and drug resistance. Converting them into prodrugs, to make them more inert, so that they can travel to the tumour site unchanged and release the drug in its active form only there, is a strategy which is the subject of much research nowadays. Read More

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http://dx.doi.org/10.2174/0929867326666181203141122DOI Listing
December 2018
4 Reads

Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Computational Systems Biology, School of Sciences - Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6681, Porto Alegre-RS 90619-900. Brazil.

Background: The enzyme trans-enoyl-[acyl carrier protein] reductase (InhA) is a central protein for the development of antitubercular drugs. This enzyme is the target for the pro-drug isoniazid, which is catalyzed by the enzyme catalase-peroxidase (KatG) to become active.

Objective: Our goal here is to review the studies on InhA, starting with general aspects and focusing on the recent structural studies, with emphasis on the crystallographic structures of complexes involving InhA and inhibitors. Read More

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http://dx.doi.org/10.2174/0929867326666181203125229DOI Listing
December 2018
8 Reads

Recent advances in multi-target anti-Alzheimer disease compounds (2013 up to present).

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211. China.

Since the last century, when scientists proposed the lock-and-key model, the discovery of drugs has focused on the development of drugs acting on single target. However, single-target drug therapies are not effective to complex diseases with multi-factorial pathogenesis. Moreover, the combination of single-target drugs readily causes drug resistance and side effects. Read More

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http://dx.doi.org/10.2174/0929867326666181203124102DOI Listing
December 2018
1 Read

Oxazole-based compounds as anticancer agents.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Dipartimento di Chimica, University of Pavia, Via Taramelli 12, 27100 Pavia. Italy.

Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various type of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the new discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. Read More

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http://dx.doi.org/10.2174/0929867326666181203130402DOI Listing
December 2018
1 Read

Discovery of Dengue Virus Inhibitors.

Curr Med Chem 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur. Malaysia.

To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4. Moreover, according to WHO, the risk of being hospitalized and having severe dengue increased in seronegative individuals after they received Dengvaxia vaccination. Read More

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http://dx.doi.org/10.2174/0929867326666181204155336DOI Listing
December 2018

Structure and function of L,D- and D,D-transpeptidase family enzymes from Mycobacterium tuberculosis.

Curr Med Chem 2018 12 3. Epub 2018 Dec 3.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001. South Africa.

Peptidoglycan, the exoskeleton of bacterial cell and an essential barrier that protects the cell, is synthesized by a pathway whose final steps are catalysed by transpeptidases, including M.tuberculosis. Knowledge of the structure and function of these vital enzymes that generate this macromolecule in M. Read More

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http://dx.doi.org/10.2174/0929867326666181203150231DOI Listing
December 2018

Role of Pro-inflammatory cytokines in regulation of skeletal muscle metabolism: A systematic review.

Curr Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana-124001. India.

Background: Metabolic pathways perturbations lead to skeletal muscular atrophy in the cachexia and sarcopenia due to increased catabolism. Pro-inflammatory cytokines induce the catabolic pathways that impair the muscle integrity and function. Hence, this review primarily concentrates on the effects of pro-inflammatory cytokines in regulation of skeletal muscle metabolism. Read More

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http://dx.doi.org/10.2174/0929867326666181129095309DOI Listing
November 2018
3 Reads

How to fluorescently label the potassium channel: A case in hERG.

Curr Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012. China.

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and drug-induced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. Read More

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http://dx.doi.org/10.2174/0929867326666181129094455DOI Listing
November 2018
4 Reads

The role of mitochondria in systemic lupus erythematosus: A glimpse of various pathogenetic mechanisms.

Curr Med Chem 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology and rheumatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan. China.

Background: Systemic lupus erythematosus (SLE) is a polysystem autoimmune disease that adversely affects human health. Various organ can be affected, including the kidney or brain. Traditional treatment methods for SLE primarily rely on glucocorticoids and immunosuppressors. Read More

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http://dx.doi.org/10.2174/0929867326666181126165139DOI Listing
November 2018
2 Reads
3.853 Impact Factor

The role of TRP channels in allergic inflammation and its clinical relevance.

Curr Med Chem 2018 Nov 25. Epub 2018 Nov 25.

Department of Physiology, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066. Korea.

Allergy refers to an abnormal adaptive immune response to non-infectious environmental substances (allergen) that can induce various diseases such as asthma, atopic dermatitis, and allergic rhinitis. In this allergic inflammation, various immune cells, such as B cells, T cells, and mast cells, are involved and undergo complex interactions that cause a variety of pathophysiological conditions. In immune cells, calcium ions play a crucial role in controlling intracellular Ca2+ signaling pathways. Read More

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http://dx.doi.org/10.2174/0929867326666181126113015DOI Listing
November 2018
1 Read

Novel Vaccine Candidates against Tuberculosis.

Curr Med Chem 2018 Nov 25. Epub 2018 Nov 25.

Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (UMR 8232), 4 Place Jussieu, 75005 Paris. France.

Ranking above AIDS, tuberculosis (TB) is the ninth leading cause of death affecting and killing many individuals every year. Drugs' efficacy is limited by serials of problems such as multi-drug resistance (MDR) and extensively-drug resistance (XDR). Meanwhile, the only licensed vaccine BCG (Bacillus Calmette-Guérin) existing for over 90 years is not effective enough. Read More

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http://dx.doi.org/10.2174/0929867326666181126112124DOI Listing
November 2018
5 Reads

Carbon nano-onions: a valuable class of carbon nanomaterials in biomedicine.

Curr Med Chem 2018 Nov 25. Epub 2018 Nov 25.

Nano Carbon Materials, Istituto Italiano di Tecnologia (IIT), via Livorno 60, 10144 Torino. Italy.

The development of nanoscale materials is an important area of research as it provides access to materials with unique properties that can be applied to improve quality of life. Multi-layer fullerenes, also known as carbon nano-onions (CNOs) are an exciting class of nanostructures which show great versatility and applicability. They find applications in several fields of technology and biomedicine. Read More

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http://dx.doi.org/10.2174/0929867326666181126113957DOI Listing
November 2018
5 Reads

Advances in carbon based nanomaterials for bio-medical applications.

Curr Med Chem 2018 Nov 25. Epub 2018 Nov 25.

Universit´e du Luxembourg, Maison du Nombre, 6, Avenue de la Fonte, L-4364 Esch-sur-Alzette. Luxembourg.

The unique mechanical, electrical, thermal, chemical and optical properties of carbon based nanomaterials (CBNs) like: Fullerenes, Graphene, Carbon nanotubes, and their derivatives made them widely used materials for various applications including biomedicine. Few recent applications of the CBNs in biomedicine include: cancer therapy, targeted drug delivery, bio-sensing, cell and tissue imaging and regenerative medicine. However, functionalization renders the toxicity of CBNs and makes them soluble in several solvents including water, which is required for biomedical applications. Read More

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http://dx.doi.org/10.2174/0929867326666181126113605DOI Listing
November 2018
2 Reads

Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies.

Curr Med Chem 2018 Nov 19. Epub 2018 Nov 19.

Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana 70125. United States.

Glycosaminoglycans (GAGs) are very complex, natural anionic polysaccharides. They are polymers of repeating disaccharide units of uronic acid and hexosamine residues. Owing to their template-free, spatiotemporally controlled, and enzyme-mediated biosyntheses, GAGs possess enormous polydispersity, heterogeneity, and structural diversity which often translate into multiple biological roles. Read More

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http://dx.doi.org/10.2174/0929867325666181120101147DOI Listing
November 2018
6 Reads

Tuberculosis - present medication and therapeutic prospects.

Curr Med Chem 2018 Nov 19. Epub 2018 Nov 19.

Poznan University of Medicinal Sciences, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Grunwaldzka Str. 6, 60-780, Poznañ. Poland.

Background: Tuberculosis (TB) has been present in the history of human civilization since time immemorial and has caused more deaths than any other infectious disease. It is still considered one of the ten most common epidemiologic causes of death in the world. As a transmissible disease, it is initiated by rod-shaped (bacillus) mycobacteria. Read More

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http://dx.doi.org/10.2174/0929867325666181120100025DOI Listing
November 2018
2 Reads

Molecular Basis of Memory: A Grand Orchestra of Pattern Formation by Hydrogen Bonds?

Authors:
Atta-Ur Rahman

Curr Med Chem 2018 Nov 19. Epub 2018 Nov 19.

Kings College, University of Cambridge, Cambridge. United Kingdom.

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http://dx.doi.org/10.2174/0929867325666181120113707DOI Listing
November 2018

Small Molecules Targeting Mutant P53: A Promising Approach For Cancer Treatment.

Curr Med Chem 2018 Nov 16. Epub 2018 Nov 16.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon. Portugal.

More than half of all human tumors express mutant forms of p53, with ovary, lung, pancreas, and colorectal cancers among the tumor types that display the highest prevalence of p53 mutations. In addition, the expression of mutant forms of p53 in tumors is associated with poor prognosis due to increased chemoresistance and invasiveness. Therefore, the pharmacological restoration of wild-type-like activity to mutant p53 arises as a promising therapeutic strategy against cancer. Read More

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http://dx.doi.org/10.2174/0929867325666181116124308DOI Listing
November 2018
2 Reads

Development of topical nanocarriers for skin cancer treatment using Quality by Design approach.

Curr Med Chem 2018 Nov 16. Epub 2018 Nov 16.

Department of Pharmaceutical Technology - University of Szeged, Szeged, H-6720, Hungary Szeged. Hungary.

Background: One of the most compelling medical challenges of this century is the treatment of cancer and among them, skin cancer is the most common type. Thus, current treatments need to be renewed continuously to handle this challenge.

Objective: This review presents considerations which can be employed during the development of nanosized formulations dedicated to the topical treatment of skin cancer. Read More

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http://dx.doi.org/10.2174/0929867325666181116143713DOI Listing
November 2018
5 Reads

Antioxidant components of Brassica vegetables including turnip and the influence of processing and storage on their anti-oxidative properties.

Curr Med Chem 2018 Nov 14. Epub 2018 Nov 14.

Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Science and Natural Resources, Gorgan. Iran.

Brassica vegetables, particularly turnip, are a rich source of natural antioxidants. This review focuses on antioxidant components and the effect of processing and storage conditions on antioxidant activities of some Brassica vegetables including turnip. Long storage times had an adverse effect on antioxidant value of turnip. Read More

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http://dx.doi.org/10.2174/0929867325666181115111040DOI Listing
November 2018

Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications.

Curr Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto. Japan.

Carbon monoxide (CO), at low concentrations, can have a variety of positive effects on the body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects. Although CO has great potential for use as a potent medical bioactive gas, for it to exist in the body in stable form, it must be associated with a carrier. Hemoglobin (Hb) represents a promising material for use as a CO carrier because most of the total CO in the body is stored associated with Hb in red blood cells (RBC). Read More

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http://www.eurekaselect.com/167311/article
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http://dx.doi.org/10.2174/0929867325666181113122340DOI Listing
November 2018
6 Reads

From recognition to reaction mechanism: an overview on the interactions between HIV-1 protease and its natural targets.

Curr Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4041. South Africa.

Current investigations of the human immunodeficiency virus protease (HIV-1 PR) as a druggable target towards the treatment of AIDS require an update to facilitate further development of promising inhibitors with improved inhibitory activities. For the past two decades, up to 100 scholarly reports appeared annually on the inhibition and catalytic mechanism of HIV-1 PR. A fundamental literature review on the prerequisite of HIV-1 PR action leading to the release of infectious virion is absent. Read More

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http://www.eurekaselect.com/167313/article
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http://dx.doi.org/10.2174/0929867325666181113122900DOI Listing
November 2018
5 Reads

An Update On The Neurochemistry Of Essential Tremor.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

University Institute of Molecular Pathology Biomarkers, UNEx. ARADyAL Instituto de Salud Carlos III, Cáceres. Spain.

Background: The pathophysiology and neurochemical mechanisms of essential tremor (ET) are not fully understood, because only a few post-mortem studies have been reported, and the lack of a good experimental model for this disease.

Objective: The main aim of this review is to update data regarding the neurochemical features of ET. Alterations of certain catecholamine systems, the dopaminergic, serotonergic, GABAergic, noradrenergic, and adrenergic systems have been described, and are the object of this revision. Read More

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http://www.eurekaselect.com/167229/article
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http://dx.doi.org/10.2174/0929867325666181112094330DOI Listing
November 2018
3 Reads

Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina. Italy.

Chronic noncommunicable diseases (NCDs), mostly represented by cardiovascular diseases, diabetes, chronic pulmonary diseases, cancers, and several chronic pathologies, are one of the main causes of morbidity and mortality, and are mainly related to the occurrence of metabolic risk factors. Anthocyanins (ACNs) posses a wide spectrum of biological activities, such as anti-inflammatory, antioxidant, cardioprotective, and chemopreventive properties, which are able to promote human health. Although ACNs present an apparent low bioavailability, their metabolites may play an important role in the in vivo protective effects observed. Read More

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http://dx.doi.org/10.2174/0929867325666181112093336DOI Listing
November 2018
5 Reads

Structural and Bioactive Studies of Halogenated Constituents from Sponges.

Authors:
Chao Li Dayong Shi

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071. China.

Marine organisms are abundant sources of bioactive natural products. Among metabolites produced by sponges and their associated microbial communities, halogenated natural compounds accounted for an important part due to their potent biological activities. The present review updates and compiles a total of 258 halogenated organic compounds isolated in the past three decades, especially brominated derivatives derived from 31 genera of marine sponges. Read More

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http://www.eurekaselect.com/167227/article
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http://dx.doi.org/10.2174/0929867325666181112092159DOI Listing
November 2018
8 Reads

Isoliquiritigenin (ISL) and its formulations: potential antitumor agents.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023. China.

Isoliquiritigenin (2',4',4-trihydroxychalcone, ISL) is one of the most important chalcone compound which mainly derived from licorice root and many other plants. It exhibits a remarkable range of potent biological and pharmacological activities such as antioxidative, antitumor, antiaging, anti-inflammatory, anti-diabetic activities, etc. Numerous research teams have demonstrated that ISL process the ability to antigrowth and proliferation in various cancer cells in vitro and in vivo. Read More

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http://dx.doi.org/10.2174/0929867325666181112091700DOI Listing
November 2018
3 Reads

Nanoparticle-Plasma Membrane interactions: thermodynamics, toxicity and cellular response.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México. Km 107 Carretera Tijuana-Ensenada, Pedregal Playitas, 22860 Ensenada, B.C. . Mexico.

Nanomaterials have become part of our daily lives, particularly nanoparticles contained in food, water, cosmetics, additives and textiles. Nanoparticles interact with organisms at the cellular level. The cell membrane is the first protective barrier against the potential toxic effect of nanoparticles. Read More

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http://dx.doi.org/10.2174/0929867325666181112090648DOI Listing
November 2018
5 Reads

Pharmaceutical Mixtures: Still A Concern For Human And Environmental Health.

Curr Med Chem 2018 Nov 7. Epub 2018 Nov 7.

University of Medicine and Pharmacy "Victor Babeș" Timișoara, Faculty of Pharmacy, 2 Eftimie Murgu, 300041, Timișoara. Romania.

In the present work, recent data onto the sources, occurrence and fate of human-use pharmaceutical active compounds (PhACs) in the aquatic environment have been reviewed. Since PhACs and their metabolites are usually present as mixtures in the environment at very low concentrations, , a particular emphasis was placed onto the PhACs mixtures, as well as on their short-term and long-term effects against human and environmental health. Moreover, a general overview of the main conventional as well as of the latest trends in wastewaters decontaminant technologies was outlined. Read More

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http://dx.doi.org/10.2174/0929867325666181108094222DOI Listing
November 2018

Manipulation of the immune system for cancer defeat: a focus on the T cell inhibitory checkpoint molecules.

Curr Med Chem 2018 11 5. Epub 2018 Nov 5.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.

The immune system actively counteracts the tumorigenesis process; a breakout of the immune system function, or its ability to recognize transformed cells, can favor cancer development. Cancer becomes able to escape from immune system control by using multiple mechanisms, which are only in part known at a cellular and molecular level. Among these mechanisms, in the last decade, the role played by the so-called "inhibitory immune checkpoints" is emerging as pivotal in preventing the tumor attack by the immune system. Read More

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http://dx.doi.org/10.2174/0929867325666181106114421DOI Listing
November 2018
7 Reads

Use of anticancer platinum compounds in combination therapies and challenges in drug delivery.

Curr Med Chem 2018 Nov 4. Epub 2018 Nov 4.

School of Pharmacy, Jilin Medical University, Jilin, 132013. China.

As one of the leading and most important metal-based drugs, platinum based pharmaceuticals are widely used in the treatment of solid malignancies. However, significant side effects and acquired drug resistance have limited their clinical applications, despite this, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nano-compositions, all show promise for the safe delivery of platinum based compounds. Read More

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November 2018
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Development of Pin1 inhibitors and their potential as therapeutic agents.

Curr Med Chem 2018 Nov 5. Epub 2018 Nov 5.

From the Department of Medical Science, Graduate School of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551. Japan.

The prolyl isomerase Pin1 is a unique enzyme, which isomerizes the cis-trans conformation between pSer/pThr and proline, and thereby regulates the function, stability and/or subcellular distribution of its target proteins. Such regulations by Pin1 are involved in numerous physiological functions as well as the pathogenic mechanisms underlying various diseases. Notably, Pin1 deficiency or inactivation is a potential cause of Alzheimer disease, since Pin1 induces the degradation of Tau. Read More

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http://dx.doi.org/10.2174/0929867325666181105120911DOI Listing
November 2018
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Current challenges in the development of vaccines and drugs against emerging vector-borne diseases.

Authors:
Kwang-Sun Kim

Curr Med Chem 2018 Nov 5. Epub 2018 Nov 5.

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241. Korea.

Vectors are living organisms that transmit infectious diseases from an infected animal to humans or another animal. Biological vectors such as mosquitoes, ticks, and sand flies carry pathogens that multiply within their bodies prior to delivery to a new host. The increased prevalence of vector-borne diseases (VBDs) such as Aedes-borne dengue, Chikungunya (CHIKV), Zika (ZIKV), malaria, tick-borne disease (TBD), and scrub typhus has a huge impact on the health of both humans and livestock worldwide. Read More

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http://dx.doi.org/10.2174/0929867325666181105121146DOI Listing
November 2018
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The Structural Details of Aspirin Molecules and Crystals.

Curr Med Chem 2018 Oct 31. Epub 2018 Oct 31.

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest. Romania.

We revisit in the key of structural chemistry one of the most known and important drugs: the aspirin. Although apparently simple, the factors determining the molecular structure and supramolecular association in crystals are not trivial. We addressed the problem from experimental and theoretical sides, considering issues from X-ray measurements and results of first-principle reconstruction of molecule and lattices by ab initio calculations. Read More

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http://dx.doi.org/10.2174/0929867325666181031132823DOI Listing
October 2018

Autophagy Modulators and Neuroinflammation.

Curr Med Chem 2018 Oct 31. Epub 2018 Oct 31.

Department of Medical Science Catholic Kwandong University International St. Mary's Hospital Incheon 22711. Korea.

Background: Neuroinflammation plays a critical role in the development and progression of various neurological disorders. Therefore, various studies have focused on the development of neuroinflammation inhibitors as potential therapeutic tools. Recently, the involvement of autophagy in the regulation of neuroinflammation has drawn substantial scientific interest, and a growing number of studies support a role of impaired autophagy in the pathogenesis of common neurodegenerative disorders. Read More

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http://dx.doi.org/10.2174/0929867325666181031144605DOI Listing
October 2018
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Onion-like carbon nanostructures: An overview of bio-applications.

Curr Med Chem 2018 10 31. Epub 2018 Oct 31.

Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok. Poland.

This article presents a brief review of the knowledge concerning onion-like carbons (OLCs). These nanostructures are some of the most fascinating carbon forms due to their unusual structure and physico-chemical properties. Generally, OLCs consist of a hollow-spherical fullerene core surrounded by concentric graphitic layers with increasing diameter. Read More

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http://dx.doi.org/10.2174/0929867325666181101105535DOI Listing
October 2018
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Nanocarriers: A Successful Tool to Increase Solubility, Stability and Optimise Bioefficacy of Natural Constituents.

Curr Med Chem 2018 11 1. Epub 2018 Nov 1.

Department of Chemistry "Ugo Schiff", University of Florence, via Ugo Schiff 6, 50121, Sesto Fiorentino, Florence. Italy.

Natural products are fascinating molecules in drug discovery for their exciting structure variability and also for their interaction with various targets. Drugs multi-targeting effect represents a more realistic approach to develop successful medications for many diseases. However, besides a large number of successful in vitro and in vivo studies, mostly of clinical trials fail. Read More

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November 2018
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Can antidiabetic drugs improve male reproductive (dys)function associated with diabetes?

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Biology of Reproduction and Stem Cell Group, CNC- Center for Neuroscience and Cell Biology, University of Coimbra 3004-504 Coimbra. Portugal.

The alarming increase in the number of diabetic patients worldwide raises concerns regarding its impact on global health, not to mention on social and economic aspects. Furthermore, the association of this complex metabolic disease with male reproductive impairment is worrying, mainly due to the increasing chances that young individuals, at the acme of their reproductive window, could be affected by the disease, further contributing to the disturbing decline in male fertility worldwide. The cornerstone of Diabetes management is glycemic control, proven to be effective in avoiding, minimizing or preventing the appearance or development of disease-related complications. Read More

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http://dx.doi.org/10.2174/0929867325666181101111404DOI Listing
November 2018
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Dynamics of T cells repertoire during Trypanosoma cruzi infection and its post-treatment modulation.

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada. Spain.

Chagas disease courses with different clinical phases and has a variable clinical presentation and progression. The acute infection phase mostly exhibits a non-specific symptomatology. In the absence of treatment, the acute phase is followed by a chronic phase, which is initially asymptomatic. Read More

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http://dx.doi.org/10.2174/0929867325666181101111819DOI Listing
November 2018
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Can we extrapolate data from one immune-mediated inflammatory disease to another one?

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar São João, Porto. Portugal.

Immune-mediated inflammatory diseases share several pathogenic pathways and this pushes sometimes to extrapolate from one disease or indication to others. A biosimilar can be defined as a biotherapeutic product which is similar in terms of quality, safety, and efficacy to an already licensed reference biotherapeutic product. We review the substrate for extrapolation, the current approval process for biosimilars and the pioneering studies on biosimilars performed in rheumatoid arthritis patients. Read More

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November 2018
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Survey of Similarity-based Prediction of Drug-protein Interactions.

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284. United States.

Therapeutic activity of a significant majority of drugs is determined by their interactions with proteins. Databases of drug-protein interactions (DPIs) primarily focus on the therapeutic protein targets while the knowledge of the off-targets is fragmented and partial. One way to bridge this knowledge gap is to employ computational methods to predict protein targets for a given drug molecule, or interacting drugs for given protein targets. Read More

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http://dx.doi.org/10.2174/0929867325666181101115314DOI Listing
November 2018

A review of drug repositioning based chemical-induced cell line expression data.

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Department of Mechanical Engineering, Department of Computer Science, University of Saskatchewan, Saskatoon. Canada.

Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. Read More

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http://www.eurekaselect.com/166913/article
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http://dx.doi.org/10.2174/0929867325666181101115801DOI Listing
November 2018
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How Often are Orphan Drugs Orphaned by the Thermochemical Community?

Curr Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250 . United States.

Orphan drug products (e.g., drugs and biologics) in the United States are those that treat people with rare chronic diseases, often cancer or metabolic disease. Read More

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http://dx.doi.org/10.2174/0929867325666181101120058DOI Listing
November 2018