5,851 results match your criteria Current Medicinal Chemistry[Journal]


Targeting n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease.

Curr Med Chem 2019 Apr 10. Epub 2019 Apr 10.

Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Av. Independencia 1027, Independencia, Santiago 8380453. Chile.

Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with oxidative stress (OS), a pro-inflammatory state and insulin resistance (IR), which are attenuated by n-3 long-chain polyunsaturated fatty acids (FAs) C20-C22 (LCPUFAs) supplementation. Main causes of NAFLD comprise high caloric intake and a sedentary lifestyle, with high intakes of saturated FAs.

Methods: The review includes several searches considering the effects of n-3 LCPUFAs in NAFLD in vivo and in vitro models, using the PubMed database from the National Library of Medicine-National Institutes of Health. Read More

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http://dx.doi.org/10.2174/0929867326666190410121716DOI Listing
April 2019
7 Reads

Role of Metal Ions Complexes and their Ligands in Medicine, Pharmacy and Cosmetology.

Authors:
Elzbieta Budzisz

Curr Med Chem 2019 ;26(4):578-579

Cosmetic Raw Materials Chemistry Faculty of Pharmacy Medical University of Lodz, Poland.

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http://dx.doi.org/10.2174/092986732604190401100950DOI Listing
January 2019
3 Reads

Role of antioxidant molecules and polymers in prevention of bacterial growth and biofilm formation.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry, Sapienza University of Rome. Italy.

Background: Antioxidants are multifaceted molecules playing a crucial role in several cellular functions. There is by now a well-established knowledge about their involvement in numerous processes associated with aging, including vascular damage, neurodegenerative diseases and cancer. An emerging area of application has been lately identified for these compounds in relation to the recent findings indicating their ability to affect biofilm formation by some microbial pathogens, including Staphylococcus aureus, Streptococcus mutans, and Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.2174/0929867326666190409120409DOI Listing
April 2019
1 Read

Role of dietary gluten in development of celiac disease and type I diabetes: management beyond gluten-free diet.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Hainan Province Key Laboratory for Sustainable Utilization of Tropical Bioresources, Hainan University, Hainan, 570228. China.

Gluten triggers celiac disease (CD) and type I diabetes in genetically predisposed population of human leukocyte antigen DQ2/DQ8+ and associates with disorders such as schizophrenia and autism. Application of a strict gluten-free diet is the only well-established treatment for patients with CD, whereas the treatment for patients with celiac type I diabetes may be depend on the timing and frequency of the diet. The application of a gluten-free diet in patients with CD may contribute to the development of metabolic syndrome and nonalcoholic fatty liver disease and may also lead to a high glycemic index, low fiber diet and micronutrient deficiencies. Read More

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http://dx.doi.org/10.2174/0929867326666190409120716DOI Listing

Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Institute of Applied Ophthalmobiology (IOBA)-University of Valladolid, Valladolid. Spain.

Background: numerous studies have analysed the effect of using different contact lenses (CLs) or care solutions, and suffering discomfort or diseases associated with CL wear on the inflammatory mediator release into the tears.

Objective: to summarize the published data on tear inflammatory molecules related to CL use.

Method: a PubMed-NCBI search has been conducted and those publications which carried out original investigations including the analysis of tear inflammatory mediators in CL wearers were selected. Read More

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http://dx.doi.org/10.2174/0929867326666190409152921DOI Listing
April 2019
1 Read

Ligand- and Structure-Based Drug Design and Optimization using KNIME.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Modeling&Informatics, Vertex Pharmaceuticals (Europe) Ltd., 86-88 Jubilee Ave, Milton Park, Abingdon-on-Thames, OX14 4RW. United Kingdom.

In recent years there has been a paradigm shift in how data is being used to progress early drug discovery campaigns from hit identification to candidate selection. Significant developments in data mining methods and the accessibility of tools for research scientists have been instrumental in reducing drug discovery timelines and in increasing the likelihood of a chemical entity achieving drug development milestones. KNIME, the Konstanz Information Miner, is a leading open source data analytics platform and has supported drug discovery endeavours for over a decade. Read More

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http://dx.doi.org/10.2174/0929867326666190409141016DOI Listing

Recent advance in polymer based microspheric systems for controlled protein and peptide delivery.

Curr Med Chem 2019 Apr 9. Epub 2019 Apr 9.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515. China.

Sustained-release systems made by biodegradable polymers for protein and peptide drug delivery have received considerable attention by academic researchers and major pharmaceutical companies around the world. Various types of biodegradable materials, including natural and synthetic polymers, have been applied to form protein and peptide drug carriers. Among these material candidates, poly lactic acid (PLA) and poly lactic-co-glycolic acid (PLGA) are the most commonly used biodegradable materials in the development of protein and peptide microspheres. Read More

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http://dx.doi.org/10.2174/0929867326666190409130207DOI Listing

Recent Advances of Chitosan and Its Derivatives in Biomedical Applications.

Curr Med Chem 2019 Apr 5. Epub 2019 Apr 5.

Institut Parisien de Chimie Moléculaire, CNRS UMR 8232, Sorbonne Université, 4 Place Jussieu, 75005 Paris. France.

Chitosan is the second-most abundant natural polysaccharide. It has unique characteristics, such as biodegradability, biocompatibility, and non-toxicity. Due to the existence of its free amine group and hydroxyl groups on its backbone chain, chitosan can undergo further chemical modifications to generate chitosan derivatives (CDs) that permit additional biomedical functionality. Read More

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http://dx.doi.org/10.2174/0929867326666190405151538DOI Listing
April 2019
1 Read

Proteins in Pharmacology: Restrictions, Challenges and Opportunities.

Curr Med Chem 2019 ;26(3):362-364

Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation.

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http://dx.doi.org/10.2174/092986732603190326151415DOI Listing
January 2019

Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.

Curr Med Chem 2019 Apr 4. Epub 2019 Apr 4.

Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001. China.

Systemic lupus erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could reveal important therapeutic approaches. Read More

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http://dx.doi.org/10.2174/0929867326666190404140658DOI Listing
April 2019
2 Reads

Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors.

Curr Med Chem 2019 Apr 1. Epub 2019 Apr 1.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009. China.

Cyclin-dependent kinase 8 (CDK8), a member of the CDKs family, has been widely focused owing to investigations of its critical roles in transcription and oncogenesis in recent years. Selective inhibition of CDK8 and its paralog CDK19 offers a novel therapeutic strategy for the treatment of some cancers. Up to now, though many small molecules against CDK8 have been discovered, most of them are discontinued in the preclinical trials due to the low selectivity and poor physicochemical properties. Read More

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http://dx.doi.org/10.2174/0929867326666190402110528DOI Listing
April 2019
4 Reads

Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy.

Curr Med Chem 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Medical school of Shiraz University,Shiraz University of Medical Sciences,Shiraz. Iran.

Autoimmune hepatitis is a necroinflammatory process of liver, featuring interface hepatitis by T cells, macrophages and plasma cells that invade to periportal parenchyma. In this process a variety of cytokines is secreted and liver tissue undergoes fibrogenesis, that cause apoptosis of hepatocytes. Autophagy is a complementary mechanism for restraining intracellular pathogens to which the innate immune system does not provide an efficient endocytosis. Read More

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http://dx.doi.org/10.2174/0929867326666190402120231DOI Listing
April 2019
2 Reads
3.853 Impact Factor

Turning fear of boron toxicity into boron-containing drug design.

Curr Med Chem 2019 Mar 27. Epub 2019 Mar 27.

Universita di Torino - Biotecnologie Molecolari Torino, Torino. Italy.

Background: Despite the historical employment of boron-containing compounds (BCCs) with medicinal purposes, the reported cases of BCC toxicity in humans during the twentieth century were driving us towards an "boron-withdrawal" period. Fortunately, the use of boric acid for specific purposes remains, and the discovery of natural BCCs with biological action attractive for therapeutic purposes as well as the introduction of some new BCCs for clinical use have reactivated the interest in studying the properties of these BCCs.

Methods: We carried out a structured search of bibliographic databases for scientific peer-reviewed research literature regarding boron toxicity and linked that information to that about BCCs in drug design and development. Read More

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http://dx.doi.org/10.2174/0929867326666190327154954DOI Listing

Obesity and body composition in man and woman: associated diseases and new role of gut microbiota.

Curr Med Chem 2019 Mar 25. Epub 2019 Mar 25.

Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome. Italy.

Background: Obesity is now recognized as a worldwide health issue and has reached epidemic proportions, affecting both developed and developing countries. The World Obesity Federation stated that "Obesity is a chronic relapsing disease process": as a result, obesity has been recognized internationally as a chronic disease. The primary cause of the metabolic syndrome and increase of the cardiovascular risk has been identified in "sick fat", a condition then defined as adiposopathy. Read More

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http://dx.doi.org/10.2174/0929867326666190326113607DOI Listing

Carnosine and diabetic nephropathy.

Curr Med Chem 2019 Mar 25. Epub 2019 Mar 25.

Centre for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg. Germany.

Diabetic nephropathy (DN) is a major complication in patients with type 1 or type 2 diabetes and represents the leading cause of end-stage renal disease. Current therapeutic options, hyperglycemia and blood pressure control, use of a statins and renin-angiotensin-aldosterone blockers, to some extent retard progression, but do not prevent the development of DN. Novel therapeutic approaches are therefore warranted. Read More

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http://dx.doi.org/10.2174/0929867326666190326111851DOI Listing

Biosimilar and Originator Product in Inflammatory Bowel Diseases: Mind the Gap?

Curr Med Chem 2019 ;26(2):246-247

Department of Biomedical Sciences, IBD Center Department of Gastroenterology, Humanitas Research Hospital Rozzano, Milan, Italy.

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http://dx.doi.org/10.2174/092986732602190314161008DOI Listing
January 2019

Targeting Immune Signaling Pathways in Clonal Hematopoiesis.

Curr Med Chem 2019 03 24. Epub 2019 Mar 24.

Department of Medicine, Section for Hematology, Haukeland University Hospital, Bergen. Norway.

Background: Myeloid neoplasms are a diverse group of malignant diseases with different entities and numerous patho-clinical features. They arise from mutated clones of hematopoietic stem- and progenitor cells which expand by outperforming their normal counterparts. The intracellular signaling profile of cancer cells is the sum of genetic, epigenetic and microenvironmental influences, and multiple interconnections between different signaling pathways make pharmacological targeting complicated. Read More

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http://dx.doi.org/10.2174/0929867326666190325100636DOI Listing
March 2019
1 Read

Immunosuppression And Immunotargeted Therapy In Acute Myeloid Leukemia - The Potential Use Of Checkpoint Inhibitors In Combination With Other Treatments.

Curr Med Chem 2019 03 24. Epub 2019 Mar 24.

Section for Hematology, Department of Medicine, Haukeland University Hospital, N-5021 Bergen. Norway.

Introduction: Immunotherapy by using checkpoint inhibitors is now tried in the treatment of several malignancies, including acute myeloid leukemia (AML). The treatment is tried both as monotherapy and as a part of combined therapy.

Methods: Relevant publications were identified through literature searches in the PubMed database. Read More

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http://dx.doi.org/10.2174/0929867326666190325095853DOI Listing
March 2019
1 Read

Obesity and cardioprotection.

Curr Med Chem 2019 Mar 24. Epub 2019 Mar 24.

Department of Clinical and Biological Sciences, University of Turin, Torino. Italy.

The incidence of obesity and diabetes is increasing rapidly worldwide. Obesity and metabolic syndrome are strictly linked and represent the basis of different cardiovascular risk factors, including hypertension and inflammatory processes predisposing to ischemic heart disease, which represents the most common causes of heart failure. Recent advances in the understanding of ischemia/reperfusion mechanisms of injury and mechanisms of cardioprotection are briefly considered. Read More

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http://dx.doi.org/10.2174/0929867326666190325094453DOI Listing
March 2019
1 Read
3.853 Impact Factor

Metabolism of Oxalate in Humans: A Potential Role Kynurenine Aminotransferase/Glutamine Transaminase/Cysteine Conjugate Beta-lyase Plays in Hyperoxaluria.

Curr Med Chem 2019 Mar 24. Epub 2019 Mar 24.

Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061. United States.

Hyperoxaluria, excessive urinary oxalate excretion, is a significant health problem worldwide. Disrupted oxalate metabolism has been implicated in hyperoxaluria and accordingly, an enzymatic disturbance in oxalate biosynthesis can result in the primary hyperoxaluria. Alanine glyoxylate aminotransferase-1 and glyoxylate reductase, the enzymes involving glyoxylate (precursor for oxalate) metabolism, have been related to primary hyperoxalurias. Read More

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http://dx.doi.org/10.2174/0929867326666190325095223DOI Listing
March 2019
2 Reads
3.853 Impact Factor

Editorial: Recent developments in the Application of Separation and Hyphenated Techniques in Current Diagnostic Challenges.

Curr Med Chem 2019 ;26(1):3-4

Department of Environmental Analysis Faculty of Chemistry, University of Gdansk Gdansk, Poland.

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http://dx.doi.org/10.2174/092986732601190314144026DOI Listing

Preface.

Authors:
Atta-Ur-Rahman

Curr Med Chem 2019 ;26(1)

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http://dx.doi.org/10.2174/092986732601190314143748DOI Listing
April 2019
1 Read

Structural basis of drug recognition by human serum albumin.

Curr Med Chem 2019 Mar 19. Epub 2019 Mar 19.

Interdepartmental Laboratory for Electron Microscopy, Roma Tre University, Via della Vasca Navale 79, I-00146 Roma. Italy.

Background: Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule with nine observed binding sites for endogenous and exogenous ligands. HSA displays an extraordinary ligand binding capacity as a depot and carrier for many compounds including most acidic drugs. Consequently, HSA has the potential to influence the pharmacokinetics and pharmacodynamics of drugs. Read More

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http://dx.doi.org/10.2174/0929867326666190320105316DOI Listing

High Resolution Nuclear Magnetic Resonance Spectroscopy on Biological Tissue and Metabolomics.

Curr Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen. China.

High-resolution nuclear magnetic resonance (NMR) spectroscopy is a universal analytical tool. It can provide detailed information on chemical shifts, J coupling constants, multiplet patterns, and relative peak areas. It plays an important role in the fields of chemistry, biology, medicine, and pharmacy. Read More

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http://dx.doi.org/10.2174/0929867326666190312130155DOI Listing

Genotype Driven Therapy for Non-Small Cell Lung Cancer: Resistance, Pan Inhibitors and Immunotherapy.

Curr Med Chem 2019 Feb 22. Epub 2019 Feb 22.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe LA 71201 . United States.

Eighty-five percent of patients with lung cancer present with non-small cell lung cancer (NSCLC). Targeted therapy approaches are promising treatments for lung cancer. However, despite the development of targeted therapies using tyrosine kinase inhibitors (TKI) as well as monoclonal antibodies, the five-year relative survival rate for lung cancer patients is still only 18%, and patients inevitably become resistant to therapy. Read More

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http://dx.doi.org/10.2174/0929867326666190222183219DOI Listing
February 2019
1 Read

B7-H3-targeted radioimmunotherapy of human cancer.

Curr Med Chem 2019 Feb 28. Epub 2019 Feb 28.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama. United States.

Background: Targeted radioimmunotherapy (RIT) is an attractive approach to selectively localize therapeutic radionuclides to malignant cells within primary and metastatic tumors while sparing normal tissues from the effects of radiation. Many human malignancies express B7-H3 on the tumor cell surface, while expression on the majority of normal tissues is limited, presenting B7-H3 as a candidate target for RIT. This review provides an overview of the general principles of targeted RIT and discusses publications that have used radiolabeled B7-H3-targeted antibodies for RIT of cancer in preclinical or clinical studies. Read More

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http://dx.doi.org/10.2174/0929867326666190228120908DOI Listing
February 2019
1 Read

Therapeutic Prospects in Preeclampsia - A Mini-review.

Curr Med Chem 2019 Feb 27. Epub 2019 Feb 27.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore. Singapore.

Background: Preeclapmsia (PE) is characterized by early onset symptoms such as elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures in the affected woman. Currently, there are no therapeutic drugs available to treat this condition, but there are interventions to regulate the symptoms based on the gestational period of the fetus, although the largely favored option is the delivery of the fetus and placenta.

Objective: A search for biomolecules associated with PE so as to identify diagnostic markers and therapeutic leads. Read More

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http://dx.doi.org/10.2174/0929867326666190228115423DOI Listing
February 2019
2 Reads
3.853 Impact Factor

Quaternized Chitosan Nanoparticles in Vaccine Applications.

Curr Med Chem 2019 Feb 27. Epub 2019 Feb 27.

Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Science, Heilongjiang University, Harbin 150080, . China.

Different natural and synthetic biodegradable polymers have been used in vaccine formulations as adjuvant and delivery system but have faced various limitations. Chitosan is a new delivery system with the potential to improve development of nano vaccines and drugs. However, chitosan is only soluble in acidic solutions of low concentration inorganic acids such as dilute acetic acid and dilute hydrochloric acid and in pure organic solvents, which greatly limits its application. Read More

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http://dx.doi.org/10.2174/0929867326666190227192527DOI Listing
February 2019
2 Reads

LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer.

Curr Med Chem 2019 Feb 27. Epub 2019 Feb 27.

Molecular Virology Section, Department of Virology and Immunology, LabPLUS, Auckland District Health Board (ADHB), Auckland, . New Zealand.

Background: Long non-coding RNAs (lncRNAs), a type of regulatory RNAs, play a key role in numerous cellular pathways. Ectopic expression of this group of non-coding RNAs has been specified to be involved in numerous diseases. Moreover, the role of lncRNAs in the initiation and development of cancers including colorectal cancer (CRC) has been acknowledged. Read More

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http://dx.doi.org/10.2174/0929867326666190227230024DOI Listing
February 2019
3.853 Impact Factor

An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry.

Curr Med Chem 2019 Feb 27. Epub 2019 Feb 27.

National Institute of Pharmaceutical Education and Research Raebareli, New Transit Campus, Bijnor Road, Sarojani Nagar Near CRPF Base Camp, Lucknow 226002, U.P., . India.

Macrocycles cover a small segment of molecules with a vast range of biological activity in the chemotherapeutic world. Primarily, the natural sources derived macrocyclic drug candidates with a wide range of biological activities are known. Further evolutions of the medicinal chemistry towards macrocycle-based chemotherapeutics involve the functionalization of the natural product by hemisynthesis. Read More

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http://dx.doi.org/10.2174/0929867326666190227232721DOI Listing
February 2019

Non-steroidal Anti-inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions.

Curr Med Chem 2019 Feb 27. Epub 2019 Feb 27.

c. Research Centre for Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, . Portugal.

Topical administration of drugs presents some advantages over other routes; the drug can be administered in the anatomical region to be treated, limiting the systemic distribution and side effects. However, the structure of the skin makes it a highly effective barrier to drug permeation. Amongst the strategies to overcome this obstacle, liposomes are interesting vehicles in the purpose of delivering the drugs into the skin, the synovial cavity or other regions affected by inflammatory or degenerative conditions. Read More

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http://dx.doi.org/10.2174/0929867326666190227233321DOI Listing
February 2019
10 Reads

Atherosclerosis and Nanomedicine Potential: Current Advance and Future Opportunities.

Curr Med Chem 2019 Mar 1. Epub 2019 Mar 1.

School of Medicine, University of Electronic Science and Technology of China, Chengdu . China.

Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of the global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and anti-inflammatory therapy. Read More

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http://dx.doi.org/10.2174/0929867326666190301143952DOI Listing
March 2019
1 Read

Insights into the design of inhibitors of the urease enzyme - a major target for the treatment of Helicobacter pylori infections.

Curr Med Chem 2019 Mar 1. Epub 2019 Mar 1.

Faculty of Pharmaceutical Sciences, University of Campinas - UNICAMP, Rua Cândido Portinari 200, 13083-871 Campinas-SP. Brazil.

Expressed by a variety of plants, fungi and bacteria, the urease enzyme is directly associated with the virulence factor of many bacteria, including Helicobacter pylori, a gram-negative bacterium related with several gastrointestinal diseases and responsible for one of the most frequent bacterial infections throughout the world. The Helicobacter pylori urease (HPU) is a nickel-dependent metalloenzyme expressed in response to the environmental stress caused by the acidic pH of the stomach. The enzyme promotes the increase of gastric pH through acid neutralization by the products of urea hydrolysis, then critically contributing to the colonization and pathogenesis of the microorganism. Read More

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http://dx.doi.org/10.2174/0929867326666190301143549DOI Listing
March 2019
2 Reads

Nanostructured calcium-based biomaterials and their application in drug delivery.

Curr Med Chem 2019 Feb 22. Epub 2019 Feb 22.

Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR. China.

In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate, are ideal candidates for drug delivery. Read More

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http://dx.doi.org/10.2174/0929867326666190222193357DOI Listing
February 2019
3.853 Impact Factor

Carbohydrate Scaffolds for the Study of the Autism-associated Bacterium, Clostridium bolteae.

Curr Med Chem 2019 Feb 25. Epub 2019 Feb 25.

Department of Chemistry, University of Guelph, Guelph, ON. Canada.

A large number of children in the autism spectrum disorder suffer from gastrointestinal (GI) conditions, such as constipation and diarrhea. Clostridium bolteae is part of a set of pathogens being regularly detected in the stool samples of hosts affected by GI and autism symptoms. Accompanying studies have pointed to the possibility that such microbes affect behaviour through the production of neurotoxic metabolites in a so-called, gut-brain connection. Read More

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http://dx.doi.org/10.2174/0929867326666190225164527DOI Listing
February 2019
2 Reads

Molecular Basis of Memory: A Grand Orchestra of Pattern Formation by Hydrogen Bonds?

Authors:
Atta-Ur-Rahman

Curr Med Chem 2018 ;25(42):5800-5802

Kings College, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.2174/092986732542181220144316DOI Listing

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006. China.

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. Read More

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http://dx.doi.org/10.2174/0929867326666190215113522DOI Listing
February 2019

Recent Development on Anti-Obesity Compounds and Their Mechanisms of Action: A Review.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine,Changsha, 410208. China.

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. In spite of the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of novel and known compounds have at least partially been revealed. Read More

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http://dx.doi.org/10.2174/0929867326666190215114359DOI Listing
February 2019
1 Read
3.853 Impact Factor

Mitochondria Associated Membranes (MAMs): Emerging drug targets for diabetes.

Curr Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Biochemistry and Molecular Mechanism Laboratory Agro-processing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala. India.

MAMs, the physical association between the endoplasmic reticulum (ER) and mitochondria are functional domains, performing a significant role in the maintenance of cellular homeostasis. It is evolving as an important signaling center that coordinates nutrient and hormonal signaling for the proper regulation of hepatic insulin action and glucose homeostasis. Moreover, MAMs can be considered as hot spots for the transmission of stress signals from ER to mitochondria. Read More

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http://dx.doi.org/10.2174/0929867326666190212121248DOI Listing
February 2019
5 Reads

Diabetic Cognitive Dysfunction: From Bench to Clinic.

Curr Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Institute of Respiratory Diseases, the Second Affiliated Hospital, Army Medical University, Chongqing, 400037. China.

Type 2 diabetes increases the risk of developing cognitive dysfunction in the elderly in the form of short-term memory and executive function impairment. Genetic and diet-induced models of type 2 diabetes further support this link, displaying deficits in working memory, learning, and memory performance. The risk factors for diabetic cognitive dysfunction include vascular disease, hypoglycaemia, hyperlipidaemia, adiposity, insulin resistance, lifestyle factors, and genetic factors. Read More

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http://dx.doi.org/10.2174/1871530319666190206225635DOI Listing
February 2019
1 Read

Targeted Radionuclide Therapy of Painful Bone Metastases: Past Developments, Current Status, Recent Advances and Future Directions.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Medical Isotopes Program, Isotope Development Group, MS 6229, Bldg. 4501, Oak Ridge National Laboratory, PO Box 2008, 1 Bethel Valley Road, Oak Ridge, TN, 37831. United States.

Bone pain arising from secondary skeletal malignancy constitutes one of the most common types of chronic pain among patients with cancer which can lead to rapid deterioration in quality of life. Radionuclide therapy using bone-seeking radiopharmaceuticals based on the concept of localization of the agent at the bone metastases sites to deliver focal cytotoxic levels of radiation emerged as an effective treatment modality for the palliation of symptomatic bone metastases. Bone-seeking radiopharmaceuticals not only provide palliative benefit but also improve clinical outcomes in term of overall and progression-free survival. Read More

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http://dx.doi.org/10.2174/0929867326666190201142814DOI Listing
February 2019
1 Read
3.853 Impact Factor

Cardioprotective Properties Of Hdl: Structural And Functional Considerations.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina. Greece.

Background: As Mendelian randomization (MR) studies showed no efficacy of variants altering HDL-cholesterol (HDL-C) levels concerning cardiovascular disease (CVD) and novel therapeutic interventions aiming to raise HDL-C resulted to futility, the usefulness of HDL-C is unclear.

Objective: As the role of HDL-C is currently doubtful, it is suggested that the atheroprotective functions of HDLs can be attributed to the number of HDL particles,and their characteristicsincludingtheir lipid and protein components.Scientific interest has focused on HDL function and on the causes of rendering HDL particles dysfunctional, whereas the relevance of HDL subclasses with CVD remains controversial. Read More

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http://dx.doi.org/10.2174/0929867326666190201142321DOI Listing
February 2019

Progress of individualized chemotherapy for gastric carcinoma under the guidance of genetic testing.

Curr Med Chem 2019 02 4. Epub 2019 Feb 4.

Cancer Institute, The Affiliated People's Hospital of Jiangsu University, No 8 Dianli Road, Zhenjiang, Jiangsu. China.

Background: Gastric cancer is a major malignancy that has high incidence rates worldwide. Approximately 30% of patients with gastric cancer have progressed into advanced stages at the time of diagnosis. Chemotherapy is the standard-of-care for most advanced gastric cancer and elicits variable responses among patients. Read More

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http://dx.doi.org/10.2174/0929867326666190204123101DOI Listing
February 2019
2 Reads

Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase.

Authors:
Miroslav Pohanka

Curr Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001 Hradec Kralove. Czech Republic.

Two cholinesterases exist: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart of the detoxification of some drugs and secondary metabolites from plants. Thus both AChE and BChE can serve as biochemical markers of various pathologies. Read More

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http://dx.doi.org/10.2174/0929867326666190130161202DOI Listing
January 2019

Exosome-Like Nanoparticles: A New Type Of Nanocarrier.

Curr Med Chem 2019 Jan 29. Epub 2019 Jan 29.

Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057, Braga. Portugal.

Nanoparticles are one of the most used systems for imaging or therapeutic drug delivery. Exosomes are nanovesicular carriers that transport cargo for intercellular communication. These nanovesicles are linked to the pathology of some major diseases, in some cases with a central role in their progression. Read More

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http://dx.doi.org/10.2174/0929867326666190129142604DOI Listing
January 2019

Comprehensive Review On Graphene Oxide For Use In Drug Delivery System.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208. China.

Motivated by the accomplishment of carbon nano tubes (CNTs), graphene and graphene oxide (GO) have been widely investigated in the previous quite a long while as an innovative medication nanocarrier for the stacking of a variety of therapeutics as well as anti-cancer medications, ineffectively dissolvable medications, anti-microbials, antibodies, peptides, DNA, RNA and genes. The greatly huge surface region of graphene, with each molecule uncovered on its two sides, is took into consideration ultra-high medication stacking effectiveness. Graphene and GO have been widely investigated by way of the absolute greatest encouraging biomaterials for biomedical applications as they have exceptional qualities: two-dimensional planar structure, substantial surface territory, chemical and mechanical constancy, sublime conductivity and great biocompatibility. Read More

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http://dx.doi.org/10.2174/1381612825666190201120013DOI Listing
February 2019
2 Reads
3.853 Impact Factor

Current anti-inflammatory therapies and the potential of secretory Phospholipase A2 inhibitors in the design of new anti-inflammatory drugs: a review of 2012 - 2018.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Molecular Modeling Laboratory, Chemistry Department, Federal University of Lavras, Lavras, 37200-000. Brazil.

The inflammatory process is a natural self-defense response of the organism to damage agents and its action mechanism involves a series of complex reactions. However, in some cases, this process can become chronic , causing much harm to the body. Therefore, over the years, many anti-inflammatory drugs have been developed aiming to decrease the concentrations of inflammatory mediators in the organism, which is a way of controlling these abnormal chain reactions. Read More

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http://dx.doi.org/10.2174/0929867326666190201120646DOI Listing
February 2019
1 Read

Thioredoxin, glutathione and related molecules in tumors of the nervous system.

Curr Med Chem 2019 Jan 31. Epub 2019 Jan 31.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa. Portugal.

Background: Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.

Objective: In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e. Read More

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http://www.eurekaselect.com/169547/article
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http://dx.doi.org/10.2174/0929867326666190201113004DOI Listing
January 2019
4 Reads

Current Trends in Medicinal Chemistry of Photoprotection and Phototherapy.

Curr Med Chem 2018 ;25(40):5466-5468

Centre for Innovative Biotechnological Investigations NANOLAB (CIBI-NANOLAB) Moscow, Russian Federation.

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http://dx.doi.org/10.2174/092986732540181120104620DOI Listing