5,816 results match your criteria Current Medicinal Chemistry[Journal]


Molecular Basis of Memory: A Grand Orchestra of Pattern Formation by Hydrogen Bonds?

Authors:
Atta-Ur-Rahman

Curr Med Chem 2018 ;25(42):5800-5802

Kings College, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.2174/092986732542181220144316DOI Listing
January 2018

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006. China.

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. Read More

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http://dx.doi.org/10.2174/0929867326666190215113522DOI Listing
February 2019

Recent Development on Anti-Obesity Compounds and Their Mechanisms of Action: A Review.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine,Changsha, 410208. China.

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. In spite of the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of novel and known compounds have at least partially been revealed. Read More

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http://dx.doi.org/10.2174/0929867326666190215114359DOI Listing
February 2019
1 Read
3.853 Impact Factor

Mitochondria Associated Membranes (MAMs): Emerging drug targets for diabetes.

Curr Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Biochemistry and Molecular Mechanism Laboratory Agro-processing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala. India.

MAMs, the physical association between the endoplasmic reticulum (ER) and mitochondria are functional domains, performing a significant role in the maintenance of cellular homeostasis. It is evolving as an important signaling center that coordinates nutrient and hormonal signaling for the proper regulation of hepatic insulin action and glucose homeostasis. Moreover, MAMs can be considered as hot spots for the transmission of stress signals from ER to mitochondria. Read More

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http://dx.doi.org/10.2174/0929867326666190212121248DOI Listing
February 2019
1 Read

Diabetic Cognitive Dysfunction: From Bench to Clinic.

Curr Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Institute of Respiratory Diseases, the Second Affiliated Hospital, Army Medical University, Chongqing, 400037. China.

Type 2 diabetes increases the risk of developing cognitive dysfunction in the elderly in the form of short-term memory and executive function impairment. Genetic and diet-induced models of type 2 diabetes further support this link, displaying deficits in working memory, learning, and memory performance. The risk factors for diabetic cognitive dysfunction include vascular disease, hypoglycaemia, hyperlipidaemia, adiposity, insulin resistance, lifestyle factors, and genetic factors. Read More

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http://dx.doi.org/10.2174/1871530319666190206225635DOI Listing
February 2019
1 Read

Targeted Radionuclide Therapy of Painful Bone Metastases: Past Developments, Current Status, Recent Advances and Future Directions.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Medical Isotopes Program, Isotope Development Group, MS 6229, Bldg. 4501, Oak Ridge National Laboratory, PO Box 2008, 1 Bethel Valley Road, Oak Ridge, TN, 37831. United States.

Bone pain arising from secondary skeletal malignancy constitutes one of the most common types of chronic pain among patients with cancer which can lead to rapid deterioration in quality of life. Radionuclide therapy using bone-seeking radiopharmaceuticals based on the concept of localization of the agent at the bone metastases sites to deliver focal cytotoxic levels of radiation emerged as an effective treatment modality for the palliation of symptomatic bone metastases. Bone-seeking radiopharmaceuticals not only provide palliative benefit but also improve clinical outcomes in term of overall and progression-free survival. Read More

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http://dx.doi.org/10.2174/0929867326666190201142814DOI Listing
February 2019
1 Read
3.853 Impact Factor

Cardioprotective Properties Of Hdl: Structural And Functional Considerations.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina. Greece.

Background: As Mendelian randomization (MR) studies showed no efficacy of variants altering HDL-cholesterol (HDL-C) levels concerning cardiovascular disease (CVD) and novel therapeutic interventions aiming to raise HDL-C resulted to futility, the usefulness of HDL-C is unclear.

Objective: As the role of HDL-C is currently doubtful, it is suggested that the atheroprotective functions of HDLs can be attributed to the number of HDL particles,and their characteristicsincludingtheir lipid and protein components.Scientific interest has focused on HDL function and on the causes of rendering HDL particles dysfunctional, whereas the relevance of HDL subclasses with CVD remains controversial. Read More

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http://dx.doi.org/10.2174/0929867326666190201142321DOI Listing
February 2019

Progress of individualized chemotherapy for gastric carcinoma under the guidance of genetic testing.

Curr Med Chem 2019 02 4. Epub 2019 Feb 4.

Cancer Institute, The Affiliated People's Hospital of Jiangsu University, No 8 Dianli Road, Zhenjiang, Jiangsu. China.

Background: Gastric cancer is a major malignancy that has high incidence rates worldwide. Approximately 30% of patients with gastric cancer have progressed into advanced stages at the time of diagnosis. Chemotherapy is the standard-of-care for most advanced gastric cancer and elicits variable responses among patients. Read More

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http://dx.doi.org/10.2174/0929867326666190204123101DOI Listing
February 2019

Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase.

Authors:
Miroslav Pohanka

Curr Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001 Hradec Kralove. Czech Republic.

Two cholinesterases exist: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart of the detoxification of some drugs and secondary metabolites from plants. Thus both AChE and BChE can serve as biochemical markers of various pathologies. Read More

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http://dx.doi.org/10.2174/0929867326666190130161202DOI Listing
January 2019

Exosome-Like Nanoparticles: A New Type Of Nanocarrier.

Curr Med Chem 2019 Jan 29. Epub 2019 Jan 29.

Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057, Braga. Portugal.

Nanoparticles are one of the most used systems for imaging or therapeutic drug delivery. Exosomes are nanovesicular carriers that transport cargo for intercellular communication. These nanovesicles are linked to the pathology of some major diseases, in some cases with a central role in their progression. Read More

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http://dx.doi.org/10.2174/0929867326666190129142604DOI Listing
January 2019

Comprehensive Review On Graphene Oxide For Use In Drug Delivery System.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208. China.

Motivated by the accomplishment of carbon nano tubes (CNTs), graphene and graphene oxide (GO) have been widely investigated in the previous quite a long while as an innovative medication nanocarrier for the stacking of a variety of therapeutics as well as anti-cancer medications, ineffectively dissolvable medications, anti-microbials, antibodies, peptides, DNA, RNA and genes. The greatly huge surface region of graphene, with each molecule uncovered on its two sides, is took into consideration ultra-high medication stacking effectiveness. Graphene and GO have been widely investigated by way of the absolute greatest encouraging biomaterials for biomedical applications as they have exceptional qualities: two-dimensional planar structure, substantial surface territory, chemical and mechanical constancy, sublime conductivity and great biocompatibility. Read More

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http://dx.doi.org/10.2174/1381612825666190201120013DOI Listing
February 2019
1 Read
3.853 Impact Factor

Current anti-inflammatory therapies and the potential of secretory Phospholipase A2 inhibitors in the design of new anti-inflammatory drugs: a review of 2012 - 2018.

Curr Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Molecular Modeling Laboratory, Chemistry Department, Federal University of Lavras, Lavras, 37200-000. Brazil.

The inflammatory process is a natural self-defense response of the organism to damage agents and its action mechanism involves a series of complex reactions. However, in some cases, this process can become chronic , causing much harm to the body. Therefore, over the years, many anti-inflammatory drugs have been developed aiming to decrease the concentrations of inflammatory mediators in the organism, which is a way of controlling these abnormal chain reactions. Read More

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http://dx.doi.org/10.2174/0929867326666190201120646DOI Listing
February 2019

Thioredoxin, glutathione and related molecules in tumors of the nervous system.

Curr Med Chem 2019 Jan 31. Epub 2019 Jan 31.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa. Portugal.

Background: Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.

Objective: In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e. Read More

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http://www.eurekaselect.com/169547/article
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http://dx.doi.org/10.2174/0929867326666190201113004DOI Listing
January 2019
2 Reads

Current Trends in Medicinal Chemistry of Photoprotection and Phototherapy.

Curr Med Chem 2018 ;25(40):5466-5468

Centre for Innovative Biotechnological Investigations NANOLAB (CIBI-NANOLAB) Moscow, Russian Federation.

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http://dx.doi.org/10.2174/092986732540181120104620DOI Listing
January 2018

Updates on Neurodegenrative and Metabolic Disorders: Synthetic, Biological and Computational Aspects.

Curr Med Chem 2018 ;25(39):5291-5292

King Fahd Medical Research Center King Abdulaziz University, Saudi Arabia.

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http://dx.doi.org/10.2174/092986732539181119142202DOI Listing
February 2019

Recent Advances in the Development of New Therapeutic Tools Against Major Parasitic Diseases.

Curr Med Chem 2018 ;25(39):5238

Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche Napoli, Italy.

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http://dx.doi.org/10.2174/092986732539181119125949DOI Listing
February 2019

Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status.

Authors:
Jan Tauchen

Curr Med Chem 2019 Jan 25. Epub 2019 Jan 25.

Department of Quality of Agricultural Products, Faculty of Natural Resources, Natural and Food Products, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague - Suchdol. Czech Republic.

Background: Migraine may be described as a headache with moderate to extreme pain that is often accompanied by incapacitating neurological symptoms. It is estimated that 12% of the world population suffers from migraine. Although a number of drugs have been used for treatment of migraine, most of these are not effective for every patient and may have undesirable side-effects. Read More

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http://dx.doi.org/10.2174/0929867326666190125155947DOI Listing
January 2019

Editorial: Novel Therapeutic Strategies for the Treatment of Chronic Diseases.

Curr Med Chem 2019 01 28. Epub 2019 Jan 28.

Department of Translational Medical Sciences, Federico II University, Napoli, Italy

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http://dx.doi.org/10.2174/0929867325666190128121918DOI Listing
January 2019

Synthesis, Biological Activity and Medicinal Applications of Ruthenium Complexes Containing Carbohydrate Ligands.

Curr Med Chem 2019 Jan 24. Epub 2019 Jan 24.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa. Portugal.

The search for new metal-efficient drugs has attracted considerable attention of the scientific community. Among them, ruthenium complexes have emerged as an excellent alternative of platinum complexes. This review presents a thorough and timely coverage of the synthesis, biological activity and medicinal applications of ruthenium complexes bearing carbohydrate ligands, allowing a large community of readers, in particularly the community that works in organic, inorganic, bioorganometallic and medicinal chemistry, ready access to the most relevant examples. Read More

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http://dx.doi.org/10.2174/0929867326666190124124350DOI Listing
January 2019

tiRNAs & tRFs Biogenesis and Regulation of Diseases: A Review Pan Jiang.

Authors:
Pan Jiang Feng Yan

Curr Med Chem 2019 Jan 24. Epub 2019 Jan 24.

Department of clinical Laboratory, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research,42 Baiziting Road, Nanjing 210009, Jiangsu. China.

tiRNAs & tRFs are a class of small molecular noncoding tRNA derived from precise processing of mature or precursor tRNAs. Most tiRNAs & tRFs described originate from nucleus-encoded tRNAs, and only a few tiRNAs & tRFs have been reported. They have been suggested to play important roles in inhibiting protein synthesis, regulating gene expression, priming viral reverse transcriptases, and the modulation of DNA damage responses. Read More

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http://dx.doi.org/10.2174/0929867326666190124123831DOI Listing
January 2019

Benzimidazole-derived compounds designed for different targets of Alzheimer's disease.

Curr Med Chem 2019 Jan 24. Epub 2019 Jan 24.

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, Ankara. Turkey.

Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various drugs, available today, employed for the treatment of different diseases. Although, there is no benzimidazole moiety containing drug available today for the treatment of Alzheimer's Disease (AD), there have been many benzimidazole derivative compounds designed and synthesized to act on some of the validated and non-validated targets of AD. Read More

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http://dx.doi.org/10.2174/0929867326666190124123208DOI Listing
January 2019

Oxidative Status in Multiple Sclerosis and Off-Targets of Antioxidants: the Case of Edaravone.

Curr Med Chem 2019 Jan 24. Epub 2019 Jan 24.

San Raffaele Roma Open University, Department of Human Sciences and Quality of Life Promotion, Rome. Italy.

Background: MS is a chronic inflammatory disease of the CNS leading to demyelination and neurodegeneration, with a complex and still to be clarified aetiology. Several data, coming from patients' samples and from animal models, show that oxidative status (OS) plays an important role in MS pathogenesis. Overproduction of reactive oxidative species by macrophages/microglia can bring about cellular injury and ensuing cell death by oxidizing cardinal cellular components. Read More

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http://dx.doi.org/10.2174/0929867326666190124122752DOI Listing
January 2019
1 Read

Obesity therapy: how and why?

Curr Med Chem 2019 01 24. Epub 2019 Jan 24.

Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence. Italy.

Background: Obesity represents the second preventable mortality cause worldwide, and is very often associated with type 2 diabetes mellitus (T2DM). The first line treatment is lifestyle modification to weight-loss, but for who fails the goal or has difficulty in maintaining achieved results, pharmacological treatment is needed. Few drugs are available up today, because of their side effects. Read More

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http://dx.doi.org/10.2174/0929867326666190124121725DOI Listing
January 2019
7 Reads

Biomarkers, Biosensors and Biomedicine.

Curr Med Chem 2019 Jan 23. Epub 2019 Jan 23.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco. Brazil.

The discovery of new biomarkers associated with cancer, neurological and cardiovascular diseases is necessary, since these are common, recurrent diseases considered as leading causes of death in the human population. Molecular signatures of these disorders that can be identified at the outset of their pathogenesis leading to prompt and targeted treatment may increase patient survival. Cancer is a heterogeneous disease that can be expressed differently among individuals; in addition, treatments may have a differentiated approach according with the type of malignant neoplasm. Read More

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http://www.eurekaselect.com/169305/article
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http://dx.doi.org/10.2174/0929867326666190124103125DOI Listing
January 2019
3 Reads

Differential characteristics of HMGB2 versus HMGB1 and their perspectives in ovary and prostate cancer.

Curr Med Chem 2019 Jan 23. Epub 2019 Jan 23.

EXPRELA Group, Centro de Investigacións Científicas Avanzadas (CICA), Departamento de Bioloxía. Facultade de Ciencias, INIBIC- Universidade da Coruña, Campus de A Coruña, 15071, A Coruña. Spain.

We have summarized the common and differential functions of HMGB1 and HMGB2 proteins with reference to pathological processes, with a special focus on cancer. Currently, several "omic" approaches help us compare the relative expression of these 2 proteins in healthy and cancerous human specimens, as well as in a wide range of cancer-derived cell lines, or in fetal versus adult cells. Molecules that interfere with HMGB1 functions, though through different mechanisms, have been extensively tested as therapeutic agents in animal models in recent years, and their effects are summarized. Read More

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http://dx.doi.org/10.2174/0929867326666190123120338DOI Listing
January 2019

Structural Insights into Azole-based Inhibitors of Heme Oxygenase-1: Development of Selective Compounds for Therapeutic Applications.

Curr Med Chem 2018 ;25(42):5803-5821

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.

The development of isozyme-selective heme oxygenase (HO) inhibitors promises powerful pharmacological tools to elucidate the regulatory characteristics of the HO system. It is already known that HO has cytoprotective properties with a role in several disease states; thus, it is an enticing therapeutic target. Historically, the metalloporphyrins have been used as competitive HO inhibitors based on their structural similarity to the substrate, heme. Read More

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http://dx.doi.org/10.2174/0929867325666180606082512DOI Listing
January 2018

Metabolism of Rhaponticin and Activities of Its Metabolite, Rhapontigenin: A Review.

Curr Med Chem 2019 Jan 21. Epub 2019 Jan 21.

School of Food Science and Technology, School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053. China.

Rhaponticin is a stilbenoid glucoside compound, can be found in medicinal plant of rhubarb rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has shown various biological activities including anticancer activities to act a potential human cytochrome P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial activities. Moreover, it was reported to scavenge intravellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylliydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). Read More

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http://dx.doi.org/10.2174/0929867326666190121143252DOI Listing
January 2019
2 Reads

The therapeutic potential of novel kappa opioid receptor-based treatments.

Curr Med Chem 2019 Jan 21. Epub 2019 Jan 21.

La Maddalena Cancer center Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna. Italy.

Introduction: Similarly to the µ opioid receptor, kappa opioid receptor (KOR), is present either in the central nervous system and peripherally. In the last years several molecules, able to interact with KOR, have been the focus of basic research for their therapeutic potential in the field of chronic pain, as well as in depression, autoimmune disorders and neurological diseases. Topic The role of KOR system and the consequent clinical effects derived by its activation or inhibition are discussed. Read More

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http://dx.doi.org/10.2174/0929867326666190121142459DOI Listing
January 2019
2 Reads

Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide.

Curr Med Chem 2019 Jan 21. Epub 2019 Jan 21.

Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.Mi.S), Policlinico "Paolo Giaccone", Università di Palermo; Via del Vespro 129, 90127 Palermo . Italy.

Background: Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the microsomal triglyceride transfer protein (MTP) approved as a novel drug for the management of homozygous familial hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine.

Aims: The present review aims at summarizing the recent knowledge on lomitapide in the management of HoFH. Read More

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http://dx.doi.org/10.2174/0929867326666190121120735DOI Listing
January 2019
5 Reads

The Biotin Biosynthetic Pathway in Mycobacterium tuberculosis is a Validated Target for the Development of Antibacterial Agents.

Curr Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455. United States.

Mycobacterium tuberculosis, responsible tuberculosis (TB), remains the leading cause of mortality among infectious diseases worldwide from a single infectious agent, with an estimated 1.7 million deaths in 2016. Biotin is an essential cofactor in M. Read More

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http://dx.doi.org/10.2174/0929867326666190119161551DOI Listing
January 2019
2 Reads

Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice.

Curr Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Diabetes Center, 1st Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital. Greece.

Endothelium plays an essential role in human homeostasis by regulating arterial blood pressure, distributing nutrients and hormones as well as providing a smooth surface that modulates coagulation, fibrinolysis and inflammation. Endothelial dysfunction is present in diabetes mellitus (DM) and contributes to the development and progression of macrovascular disease, while it is also associated with most of the microvascular complications such as diabetic retinopathy, nephropathy and neuropathy. Hyperglycemia, insulin resistance, hyperinsulinemia and dyslipidemia are the main factors involved. Read More

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http://dx.doi.org/10.2174/0929867326666190119154152DOI Listing
January 2019
4 Reads

Annexins Bend Wound Edges during Plasma Membrane Repair.

Curr Med Chem 2019 Jan 21. Epub 2019 Jan 21.

Membrane Integrity Group, Unit for Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen. Denmark.

The plasma membrane of eukaryotic cells defines the boundary to the extracellular environment and, thus provides essential protection from the surroundings. Consequently, disruptions to the cell membrane triggered by excessive mechanical or biochemical stresses pose fatal threats to cells, which they need to cope with to survive. Eukaryotic cells cope by activating their plasma membrane repair system, which is shared by other cellular functions, and includes mechanisms to remove damaged membrane by internalization (endocytosis), shedding, re-organization of cytoskeleton and membrane fusion events to reseal the membrane. Read More

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http://dx.doi.org/10.2174/0929867326666190121121143DOI Listing
January 2019
2 Reads

Advances in the Development of Potential Anti-Invasive Drugs and Strategies Focused on Overcoming Drug Resistance.

Curr Med Chem 2018 ;25(38):4970-4971

School of Chinese Medicine Hong Kong Baptist University, China.

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http://dx.doi.org/10.2174/092986732538181119121749DOI Listing
February 2019
1 Read

Therapeutic applications of Peptides against Zika Virus: A Review.

Curr Med Chem 2019 Jan 10. Epub 2019 Jan 10.

Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-110019. India.

Zika virus (ZIKV) belongs to the class of flavivirus that can be transmitted by Aedes mosquitoes. The number of Zika virus caused cases of acute infections, neurological disorders and congenital microcephaly are rapidly growing and therefore, in 2016 the World Health Organization declared a global "Public Health Emergency of International Concern". Anti-ZIKV therapeutic and vaccine development strategies are growing worldwide in recent years, however, no specific and safe treatment is available till date to save the human life. Read More

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http://dx.doi.org/10.2174/0929867326666190111115132DOI Listing
January 2019
4 Reads

Nano-biofilm Arrays as a Novel Universal Platform for Microscale Microbial Culture and High-Throughput Downstream Applications.

Curr Med Chem 2019 Jan 7. Epub 2019 Jan 7.

Department of Biology and SouthTexas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, 78249. United States.

Biofilms are the predominant mode of microbial growth and it is now fully accepted that a majority of infections in humans are associated with a biofilm etiology. Biofilms are defined as attached and structured microbial communities surrounded by a protective exopolymeric matrix. Importantly, sessile microorganisms growing within a biofilm are highly resistant to antimicrobial agents. Read More

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http://dx.doi.org/10.2174/0929867326666190107155953DOI Listing
January 2019
1 Read

Therapeutic Targeting of the Soluble Guanylate Cyclase.

Curr Med Chem 2019 01 7. Epub 2019 Jan 7.

Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505. Greece.

The soluble guanylate cyclase (sGC) is the physiological sensor for nitric oxide and alterations of its function are actively implicated in a wide variety of pathophysiological conditions. Intense research efforts over the past 20 years have provided significant information on its regulation, culminating in the rational development of approved drugs or investigational lead molecules, which target and interact with sGC through novel mechanisms. However, there are numerous questions that remain unanswered. Read More

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http://dx.doi.org/10.2174/0929867326666190108095851DOI Listing
January 2019
2 Reads

Vanadium and Oxidative Stress Markers - In Vivo Model: a review.

Curr Med Chem 2019 Jan 7. Epub 2019 Jan 7.

Laboratory of Oxidative Stress, Centre for Interdisciplinary Research, Faculty of Biotechnology and Environmental Sciences, The John Paul II Catholic University of Lublin, Lublin. Poland.

This review article is an attempt to summarize the current state of knowledge of the impact of vanadium (V) on oxidative stress (OS) markers in vivo. It shows the results of our studies and studies conducted by other researchers on the influence of different V compounds on the level of selected reactive oxygen species (ROS)/free radicals (FRs), markers of lipid peroxidation (LPO), as well as enzymatic and non-enzymatic antioxidants. It also presents the impact of ROS/peroxides on the activity of antioxidant enzymes modulated by V and illustrates the mechanisms of the inactivation thereof caused by this metal and reactive oxygen metabolites. Read More

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http://dx.doi.org/10.2174/0929867326666190108112255DOI Listing
January 2019
6 Reads

Management of peripheral neuropathy induced by chemotherapy.

Curr Med Chem 2019 Jan 7. Epub 2019 Jan 7.

Department of Oncology, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer. Israel.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is considered a severe side effect of therapeutic agents with limited treatment options. The incidence of CIPN in cancer patients is approximately 3-7% in cytostatic monotherapy and as high as 38% in cases of poly-chemotherapy. The prevalence of CIPN was found to be 68% within the first month of chemotherapy treatment. Read More

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http://dx.doi.org/10.2174/0929867326666190107163756DOI Listing
January 2019
7 Reads

Metabolomic Biomarkers in Gynecology: a Treasure Path or a False Path?

Curr Med Chem 2019 01 4. Epub 2019 Jan 4.

Institute of Perinatology and Pediatric, Almazov National Medical Research Centre . Russian Federation.

Omic-technologies (genomics, transcriptomics, proteomics and metabolomics) have become more important in current medical science. Among them, it is metabolomics that most accurately reflects the minor changes in body functioning, as it focuses on metabolome - the group of the metabolism products, both intermediate and end. Therefore, metabolomics is actively engaged in fundamental and clinical studies and search for potential biomarkers. Read More

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http://dx.doi.org/10.2174/0929867326666190104124245DOI Listing
January 2019
4 Reads

Reversine: A Synthetic Purine with a Dual Activity as a Cell Dedifferentiating Agent and a Selective Anticancer Drug.

Curr Med Chem 2019 01 3. Epub 2019 Jan 3.

Stem Cells for Tissue Engineering Lab, IRCCS Policlinico San Donato, piazza Malan 2, +39 0252774672, 20097, San Donato Milanese, Milan. Italy.

The development of new therapeutic applications for adult and embryonic stem cells has dominated regenerative medicine and tissue engineering for several decades. However, since 2006, induced pluripotent stem cells (iPSCs) have taken center stage in the field, as they promised to overcome several limitations of the other stem cell types. Nonetheless, other promising approaches for adult cell reprogramming have been attempted over the years, even before the generation of iPSCs. Read More

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http://dx.doi.org/10.2174/0929867326666190103120725DOI Listing
January 2019
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Recent progresses in Organic-Inorganic Nano technological platforms for cancer therapeutics.

Curr Med Chem 2018 Dec 24. Epub 2018 Dec 24.

Department of Chemistry, Deshbandhu College, University of Delhi, New Delhi. India.

Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring revolutionary advancement in cancer eradication process. Oncology is achieving new heights under nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy, bio imaging and gene therapy. Read More

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http://dx.doi.org/10.2174/0929867326666181224143734DOI Listing
December 2018
3 Reads

Targeting tumour metastasis: the emerging role of nanotechnology.

Curr Med Chem 2018 Dec 19. Epub 2018 Dec 19.

Juraj Dobrila University of Pula, Zagrebačka 30, 52 100 Pula. Croatia.

Metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. Read More

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http://www.eurekaselect.com/168478/article
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http://dx.doi.org/10.2174/0929867326666181220095343DOI Listing
December 2018
6 Reads

Cardiovascular effects of flavonoids.

Curr Med Chem 2018 Dec 19. Epub 2018 Dec 19.

University of Granada - Pharmacology Granada. Spain.

Cardiovascular disease (CVD) is the major cause of death worldwide, especially in Western society. Flavonoids are a large group of polyphenolic compounds widely distributed in plants, present in considerable amount in fruit and vegetable. Several epidemiological studies found an inverse association between flavonoids intake and mortality by CVD. Read More

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http://dx.doi.org/10.2174/0929867326666181220094721DOI Listing
December 2018
20 Reads
3.853 Impact Factor

Hybrid imidazole-pyridine derivatives: an approach to novel anticancer DNA intercalators.

Curr Med Chem 2018 Dec 19. Epub 2018 Dec 19.

"Alexandru Ioan Cuza" University of Iasi, Faculty of Chemistry, 11 Carol I, Iasi 700506. Romania.

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Read More

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http://dx.doi.org/10.2174/0929867326666181220094229DOI Listing
December 2018
1 Read

Innovative Strategies for Cardioprotection.

Authors:
Lara Testai

Curr Med Chem 2018 ;25(34):4378-4379

Researcher in Pharmacology University of Pisa Department of Pharmacy Bonanno Street, 6 56120-Pisa, Italy.

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http://dx.doi.org/10.2174/092986732534181026113511DOI Listing
January 2019
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Nanomedicine in Cancer Pathology.

Authors:
Flavio Rizzolio

Curr Med Chem 2018 ;25(34):4190-4191

Ca' Foscari University of Venice Department of Molecular Science and Nanosystems, Pathology Unit, CRO - IRCCS, National Cancer Institute Venice, Italy.

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http://dx.doi.org/10.2174/092986732534181026111151DOI Listing
January 2019
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Nanotechnology Opens the Landscape of Personalized Medicine.

Authors:
Pilar Rivera Gil

Curr Med Chem 2018 ;25(35):4552

Integrative Biomedical Materials and Nanomedicine Lab Department of Experimental and Health Sciences Pompeu Fabra University, Barcelona, Spain.

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http://dx.doi.org/10.2174/092986732535181026145729DOI Listing
January 2019
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Endothelial and Circulating Progenitor Cells: Between Diseases and Therapies.

Curr Med Chem 2018 ;25(35):4476-4477

Department of Clinical and Experimental Medicine University of Messina Messina, Italy.

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http://dx.doi.org/10.2174/092986732535181026143801DOI Listing
January 2019
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Biotechnological Production of Anti-cancer Compounds.

Authors:
Sonia Malik

Curr Med Chem 2018 ;25(36):4654-4655

School of Agriculture, Food and Wine University of Adelaide, Australia.

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http://dx.doi.org/10.2174/092986732536181029110144DOI Listing
January 2019
1 Read