213 results match your criteria Current Hypertension Reviews [Journal]


Hypertension in Metabolic Syndrome: novel insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

2nd Prop Department of Internal Medicine, Aristotle University, Thessaloniki. Greece.

Background: The metabolic syndrome (MetS) is characterized by the simultaneous presence of obesity, hypertension, dyslipidemia and hyperglycemia in an individual, leading to increased cardiovascular disease (CVD) risk. It affects almost 35% of the US adult population, while its' prevalence increases with age. Elevated blood pressure is the most frequent component of the syndrome; however, up to date, the optimal antihypertensive regiment has not been defined. Read More

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http://dx.doi.org/10.2174/1573402115666190415161813DOI Listing
April 2019
2 Reads

Primary aldosteronism: novel insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki. Greece.

Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher than hypertensive individuals with equal blood pressure levels.

Objectives: To thoroughly present and critically discuss the novel insights in the field of primary aldosteronism, focusing in the clinically meaningful aspects. Read More

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http://www.eurekaselect.com/171631/article
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http://dx.doi.org/10.2174/1573402115666190415155512DOI Listing
April 2019
8 Reads

Hypertension in obesity: novel insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

3rd Department of Internal Medicine, Hypertension-24h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Backround: The relationship between obesity and hypertension has been established in both adults and children. The combination of obesity, hypertension and other cardiovascular risk factors significantly increases the likelihood of adverse cardiovascular effects and raises concerns about aggressive treatment strategies.

Objective: Despite the impressive elements which indicate an important role for excessive weight gain in increasing blood pressure, not all obese patients are hypertensive. Read More

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http://dx.doi.org/10.2174/1573402115666190415154603DOI Listing
April 2019
3 Reads

Hypertension In Chronic Kidney Disease: Novel Insights.

Curr Hypertens Rev 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Management of arterial hypertension in patients with chronic kidney disease (CKD) remains a major challenge due to its high prevalence and its associations with cardiovascular disease (CVD) and CKD progression. Several clinical trials and meta-analyses have demonstrated that aggressive treatment of hypertension in patients with and without CKD lowers the risk of CVD and all-cause mortality, nevertheless the effects of blood pressure (BP) lowering in terms of renal protection or harm remain controversial. Both home and ambulatory BP estimation have shown that patients with CKD display abnormal BP patterns outside of the office and further investigation is required, so as to compare the association of ambulatory versus office BP measurements with hard outcomes and adjust treatment strategies accordingly. Read More

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http://dx.doi.org/10.2174/1573402115666190415153554DOI Listing
April 2019
2 Reads

Perivascular Adipose Tissue Oxidative Stress On The Pathophysiology Of Cardiometabolic Diseases.

Curr Hypertens Rev 2019 Apr 10. Epub 2019 Apr 10.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas-SP. Brazil.

Most of the systemic blood vessels are surrounded by the perivascular adipose tissue (PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. Read More

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http://dx.doi.org/10.2174/1573402115666190410153634DOI Listing

Clinical and Molecular Perspectives of Monogenic Hypertension.

Curr Hypertens Rev 2019 Apr 9. Epub 2019 Apr 9.

Department of Physiology, Wayne State University School of Medicine and the John D. Dingell VA Medical Center, Detroit, Michigan, MI. United States.

Advances in molecular research techniques have enabled a new frontier in discerning the mechanisms responsible for monogenic diseases. In this review, we discuss the current research on the molecular pathways governing blood pressure disorders with a Mendelian inheritance pattern, each presenting with a unique pathophysiology. Glucocorticoid remediable aldosteronism (GRA) and apparent mineralocorticoid excess (AME) are caused by mutations in regulatory enzymes that induce increased production of mineralocorticoids or inhibit degradation of glucocorticoids, respectively. Read More

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http://dx.doi.org/10.2174/1573402115666190409115330DOI Listing
April 2019
1 Read

Ethanol induced oxidative stress in the vasculature: Friend or Foe.

Curr Hypertens Rev 2019 Mar 25. Epub 2019 Mar 25.

Center for Research Development and Scholarship, Vanderbilt University School of Nursing, Nashville, TN 37240. United States.

Oxidative stress is implicated in the etiology of many ethanol-induced pathologies. Oxidative stress has been shown to contribute to the development of endothelial dysfunction and cardiovascular disease, such as hypertension. This review details mechanisms of vascular function, the role of oxidative stress in vascular biology and how ethanol consumption may alter endothelial and smooth muscle cell function as well as microvascular function. Read More

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http://dx.doi.org/10.2174/1573402115666190325124622DOI Listing

Dietary Adherence, Self-Efficacy, and Health Behavior Change of WASHOKU-modified DASH Diet: A Sub-analysis of the DASH-JUMP Study.

Curr Hypertens Rev 2019 Mar 18. Epub 2019 Mar 18.

Department of Molecular Physiology and Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Ube. Japan.

Background: We previously reported the nutritional characteristics and effects of the DASH-JUMP diet, which is a WASHOKU-modified DASH diet, in Japanese participants with untreated high-normal blood pressure or stage 1 hypertension. The dietary adherence of the DASH diet in Japanese participants has never been evaluated before.

Objective: We aimed to assess the relationships between dietary adherence, self-efficacy, and health behavior change among study participants who received the DASH-JUMP diet by home delivery. Read More

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http://dx.doi.org/10.2174/1573402115666190318125006DOI Listing

Renal innervation in resistant hypertension: an overview of pathophysiology and renal denervation as potential treatment.

Curr Hypertens Rev 2019 Mar 1. Epub 2019 Mar 1.

Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY. United States.

Background- Advances in treatment and increased awareness have improved the prognosis for many patients with hypertension (HTN). Resistant hypertension (RH) refers to a subset of hypertensive individuals that fail to achieve a desired blood pressure (BP) despite concurrent use of 3 different classes antihypertensive agents, one being a diuretic, and proper lifestyle changes. The prevalence and prognosis of RH are unclear owning to its heterogeneous etiologies, risk factors, and secondary comorbidities. Read More

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http://dx.doi.org/10.2174/1573402115666190301154100DOI Listing
March 2019
4 Reads

The Adaptive Value and Clinical Significance of Allostatic Blood Pressure Variation

Authors:
Gary D James

Curr Hypertens Rev 2019 03 1. Epub 2019 Mar 1.

Department of Anthropology, Decker School of Nursing and Department of Biomedical Engineering Binghamton University, Binghamton, NY 13902. United States.

In recent years, there has been interest in evaluating the morbidity and mortality risk of circadian, diurnal, or nocturnal blood pressure variation. Variation is a normative property of blood pressure, necessary for survival. Like many physiological functions, blood pressure undergoes allostasis, meaning that the body does not defend a particular blood pressure value, but rather blood pressure maintains bodily stability through continual change that is initiated by constantly fluctuating internal and external environmental stimuli. Read More

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http://dx.doi.org/10.2174/1573402115666190301144316DOI Listing

Activation of the renin-angiotensin system could cause hypertension during fasting in the Muslims month of Ramadhan.

Curr Hypertens Rev 2019 Feb 13. Epub 2019 Feb 13.

Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran 1419733141. Iran.

We are of the opinion that fasting during the Muslims month of Ramadhan could cause hypertension secondary to dehydration that inevitably follows. Dehydration initiates a cascade of hormonal events that finally culminate in hypertension. This hypothesis however need to be tested in a randomized trial to be confirmed. Read More

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http://www.eurekaselect.com/169981/article
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http://dx.doi.org/10.2174/1573402115666190214112546DOI Listing
February 2019
7 Reads

Primary Prevention Of Cardiovascular Risk In Octogenarians By Risk Factors Control.

Curr Hypertens Rev 2019 Feb 11. Epub 2019 Feb 11.

Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari. Italy.

Primary prevention of cardiovascular events in older adults is a relevant problem, because of lack of evidence for safe and efficacious therapy, its costs and elderly quality of life, Italy's aging population is constantly increasing, so cardiovascular disease (CVD) primary prevention in the elderly is a prime objective. Life expectancy has dramatically increased over the last 2 decades,the proportion of individuals aged 80 years and older has grown rapidly in Europe and United States,but cost / effective ratio of CVD prevention through risk factors control is debated. It is therefore important to implement cardiovascular risk factors estimation in the elderly to maximize quality of life of patients and to lengthen their healthy life expectancy, choosing the better treatment for each patient sharing the choice with himself when it is possible, always remembering that elderly patients often have multiple co-morbidities that require a high number of concurrent medications; this may increase the risk for drug-drug interactions, thereby reducing the potential benefits of CVD prevention therapy. Read More

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http://dx.doi.org/10.2174/1573402115666190211160811DOI Listing
February 2019
9 Reads

Heart Failure.

Curr Hypertens Rev 2019 ;15(1)

Department of Cardiology Aultman Hospital, Ohio Canton, OH 44710, United States.

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http://dx.doi.org/10.2174/157340211501190129144451DOI Listing
January 2019

Home Blood Pressure-guided Anticipation Management of Hypertension: Effective to the Gap Between the Guidelines and the Individualized Medicine.

Authors:
Kazuomi Kario

Curr Hypertens Rev 2019 ;15(1):2-6

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

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http://dx.doi.org/10.2174/157340211501190129144223DOI Listing
January 2019

The role of oxidative stress, adhesion molecules and antioxidants in preeclampsia.

Curr Hypertens Rev 2019 Jan 19. Epub 2019 Jan 19.

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi. United States.

Oxidative stress is a consequence of a reduction in the antioxidant capacity and an excessive production of reactive oxygen and nitrogen species (ROS). Oxidative agents, which are overproduced due to ischemic-reperfusion injury in the placenta, may overwhelm the normal antioxidant activity. This imbalance is a key feature in the pathogenesis of preeclampsia. Read More

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http://dx.doi.org/10.2174/1573402115666190119163942DOI Listing
January 2019
2 Reads

Prevalence of HTN in Iran: Meta-analysis of published studies in 2004-2018.

Curr Hypertens Rev 2019 01 18. Epub 2019 Jan 18.

Department of Nursing, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj. Iran.

Introduction: prevalence of hypertension (HTN) is increasing in the developing countries like Iran. Various studies have reported different rates of HTN in Iran. The purpose of this study was to estimate an overall prevalence of HTN in Iran. Read More

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http://dx.doi.org/10.2174/1573402115666190118142818DOI Listing
January 2019
13 Reads

Endothelium:a target for harmful actions of metals.

Curr Hypertens Rev 2019 Jan 15. Epub 2019 Jan 15.

CardiacElectromechanicaland Vascular ReactivityLaboratory, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, Vitória, Espírito Santo. Brazil.

The use of heavy metals is closely linked to the history of mankind. They have been used as important materials in a wide variety of human activities such as manufacturing utensils and tools. Such extended use has significantly increased professional and environmental exposure to mercury, lead and cadmium. Read More

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http://dx.doi.org/10.2174/1573402115666190115153759DOI Listing
January 2019
1 Read

Depression rises the risk of hypertension incidence: discussing the link through the Ca2+/cAMP signalling.

Curr Hypertens Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Pharmacology - Escola Paulista de Medicina - Universidade Federal de São Paulo . Brazil.

Background: Depression and hypertension are medical problems both with clearly restricted pharmacotherapies, along with a high prevalence around the world. In fact, an intensive discussion in the field is that a dysregulation of the intracellular Ca2+ homeostasis (e.g. Read More

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http://dx.doi.org/10.2174/1573402115666190116095223DOI Listing
January 2019
2 Reads

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study.

Curr Hypertens Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Physiology Uttar Pradesh University of Medical Sciences Saifai, Etawah, Uttar Pradesh. India.

Objective: Assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre.

Materials And Methods: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Pre-eclampsia, Eclampsia) at ≥34 weeks gestation. Maternal serum uric acid levels were compared in three groups in relation to disease severity, mode of delivery, maternal outcome. Read More

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http://dx.doi.org/10.2174/1573402114666181112141953DOI Listing
November 2018
22 Reads

Association Between Adiposity Indices and Blood Pressure is Stronger in Sarcopenic Obese Women.

Curr Hypertens Rev 2018 Oct 31. Epub 2018 Oct 31.

College of Physical Education, UniEVANGÉLICA, Anápolis. Brazil.

Background: Anthropometric indices are useful to identify excess weight and poor health outcomes. Previous research showed that some indices are correlated to blood pressure (BP) among adults. Yet, this associations are poorly characterized in women with sarcopenic obesity (SO). Read More

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http://www.eurekaselect.com/166831/article
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http://dx.doi.org/10.2174/1573402114666181031145341DOI Listing
October 2018
2 Reads

Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice.

Curr Hypertens Rev 2018 Oct 31. Epub 2018 Oct 31.

Division of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, Michigan MI 48824. United States.

Background-This study tested the hypothesis that genetically ablation of transient receptor potential vanilloid type 1 (TRPV1) exacerbates impairment of baroreflex in mice fed a western diet (WD) and leads to distinct diurnal and nocturnal blood pressure patterns. Methods-TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were given a WD or normal diet (CON) for 4 months. Results-Capsaicin, a selective TRPV1 agonist, increased ipsilateral afferent renal nerve activity in WT but not TRPV1-/- mice. Read More

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http://dx.doi.org/10.2174/1573402114666181031141840DOI Listing
October 2018
2 Reads

Conceptual model of medication adherence in older adults with high blood pressure- An integrative review of the literature.

Curr Hypertens Rev 2018 10 22. Epub 2018 Oct 22.

Behavioral Sciences Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran. Iran.

Background: Medication adherence (MA) is the most important controlling factor of high blood pressure (HBP). There are a few MA models, but they have not been successful in predicting MA completely. Thus, this study aimed to expand a conceptual model of MA based on ecological approach. Read More

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http://www.eurekaselect.com/166520/article
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http://dx.doi.org/10.2174/1573402114666181022152313DOI Listing
October 2018
13 Reads

Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature.

Curr Hypertens Rev 2019 ;15(1):13-16

Division of Cardiovascular Medicine, University of Southern California, Los Angeles-90033, LA, United States.

Background: Myxedema heart disease is an extremely rare disease entity and should be suspected in patients with unexplained heart failure refractory to conventional treatment. Myxedema coma with co- existent heart disease is not well known and very few cases have been reported.

Conclusion: Here, we present an interesting case of myxedema coma with severe valvular cardiomyopathy followed by a concise review of the literature with special emphasis on epidemiology, pathophysiology, diagnosis and therapeutic modalities. Read More

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http://dx.doi.org/10.2174/1573402114666181001121108DOI Listing
January 2019
2 Reads

Blunted Overnight Blood Pressure Dipping in Second Trimester; A Strong Predictor of Gestational Hypertension and Preeclampsia.

Curr Hypertens Rev 2019 ;15(1):70-75

Sarem Fertility and Infertility Research Center (SAFIR), Sarem Women's Hospital, Tehran, Iran.

Background: Preeclampsia is a global burden with 10 million incidences annually and 210 daily deaths worldwide. Diagnosis is mainly based on the features following full presentation.

Objective: This study explored whether early pregnancy circadian changes of ambulatory blood pressure monitoring (ABPM) could predict preeclampsia and hypertension. Read More

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http://dx.doi.org/10.2174/1573402114666180924143801DOI Listing
January 2019
3 Reads

Three Generations of β-blockers: History, Class Differences and Clinical Applicability.

Curr Hypertens Rev 2019 ;15(1):22-31

The Rockefeller University, Laboratory of Blood and Vascular Biology, New York, NY, United States.

Background: Beta-adrenergic receptors are expressed in cardiomyocytes and activated by either noradrenaline released from sympathetic synapses or circulating catecholamines. Their corresponding receptors have three subtypes, namely, β1, β2 and β3, which are members of the G protein-coupled receptors (GPCRs) family. Activation of β1-adrenergic receptors causes various physiological reactions including cardiac contraction and renin secretion from juxtaglomerular cells of the kidney. Read More

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http://dx.doi.org/10.2174/1573402114666180918102735DOI Listing
January 2019
1 Read

Stiff Left Atrial Syndrome; Prospects and Possibilities. Retrospective Analysis and Review of the Literature.

Curr Hypertens Rev 2019 ;15(1):17-21

Division of Cardiovascular Medicine, Heart Failure Recovery and Research, Scripps Green Hospital, La Jolla-90033, CA 92037, United States.

Objectives: Stiff left atrial syndrome is an intriguing clinical phenomena characterized by reduced left atrial compliance, pulmonary venous hypertension and exacerbations of volume overload. We conducted a retrospective review of patients diagnosed with stiff left atrial syndrome at our center.

Methods: All patients admitted to our hospital with volume overload and pulmonary venous hypertension who were diagnosed with stiff left atrial syndrome based on evidence by echocardiogram and right heart catheterization between July 2011 and July 2013 were included in this retrospective review. Read More

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http://dx.doi.org/10.2174/1573402114666180917095654DOI Listing
January 2019
9 Reads

Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.

Curr Hypertens Rev 2019 ;15(1):8-12

Division of Cardiovascular Medicine, University of Southern California, Los Angeles-90033 CA, United States.

Background: Acute eosinophilic myocarditis (EM) is a rare form of heart failure that is characterized by myocardial eosinophilic infiltration usually in association with peripheral eosinophilia. The underlying cause is variable and can include allergic reactions, parasitic infection, idiopathic hypereosinophilic syndrome, malignancy, Loeffler's syndrome, Churg-Strauss syndrome (CSS), early giant cell myocarditis and malignancy. The course is potentially fatal, and early diagnosis and treatment with steroids is essential. Read More

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http://dx.doi.org/10.2174/1573402114666180903164900DOI Listing
January 2019
15 Reads

Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction?

Curr Hypertens Rev 2019 ;15(1):32-39

Department of Pharmacology-Universidade Federal de Sao Paulo-Escola Paulista de Medicina, Laboratory of Autonomic and Cardiovascular Pharmacology-55 11 5576-4973, Rua Pedro de Toledo, 669-Vila Clementino, Sao Paulo-SP, CEP: 04039-032, Brazil.

Background: Hypertension, diabetes and neurodegenerative diseases are among the most prevalent medical problems around the world, costing millions of dollars to the medical health systems. Indeed, hypertension has been associated with higher risk for decline of cognition, as evidenced in patients with Alzheimer´s disease (AD). Furthermore, there is a clear relationship between hypertension and diabetes, reflecting substantial overlap in their etiology. Read More

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http://www.eurekaselect.com/164730/article
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http://dx.doi.org/10.2174/1573402114666180817113242DOI Listing
January 2019
7 Reads

Arterial Mechanics and Dynamics in Hypertension.

Curr Hypertens Rev 2018 ;14(2):74-75

Hospital Universitario Fundacion Favaloro Buenos Aires, Argentina.

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http://dx.doi.org/10.2174/157340211402180803101849DOI Listing
January 2018
1 Read

Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension.

Curr Hypertens Rev 2018 Jul 30. Epub 2018 Jul 30.

M. M. Medical College & Hospital, Kumarhatti, Solan, Himachal Pardesh. India.

Background: Different antihypertensive therapies (especially diuretics) are reported to induce new onset of diabetes in some hypertensive patients. α-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypertension via salt sensitivity. Therefore, the G460T polymorphism of ADD1 gene may be associated with new onset of diabetes under the influence of diuretic and other antihypertensive therapies. Read More

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http://dx.doi.org/10.2174/1573402114666180731111453DOI Listing
July 2018
22 Reads

Adaptive Filtering of the Arterial Wall: Frequency Response and Dynamical Parameters: Clinical Evaluation.

Curr Hypertens Rev 2018 ;14(2):95-99

Metabolic Syndrome and Hypertension Unit, University Hospital, Favaloro Foundation, Buenos Aires, Argentina.

Adaptive identification systems focus on dynamical approaches based on the observed data from an experiment and/or clinical data. These systems establish a relationship between an input (arterial or vein instantaneous pressure) and an output (instantaneous arterial or vein diameter). Several dynamics relationships and applications can be established because of this adaptive identification as an arterial dynamic range (frequency response), biomechanical behavior of cryopreserved arteries, regional differences in veins as artery substitution, role of vascular smooth muscle in human hypertension and time invariance in the biomechanics of wall arteries. Read More

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http://dx.doi.org/10.2174/1573402114666180703164409DOI Listing
January 2018
1 Read

Differential Approaches are Much Needed for "Real World" Management of Hypertension in the Era of "Hypertension Paradox".

Authors:
Kazuomi Kario

Curr Hypertens Rev 2018 ;14(1):2-5

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

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http://dx.doi.org/10.2174/157340211401180611103932DOI Listing
April 2019
5 Reads

GUT Microbiome-GUT Dysbiosis-Arterial Hypertension: New Horizons.

Curr Hypertens Rev 2019 ;15(1):40-46

1st Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Arterial hypertension is a progressive cardiovascular syndrome arising from complex and interrelated etiologies. The human microbiome refers to the community of microorganisms that live in or on the human body. They influence human physiology by interfering in several processes such as providing nutrients and vitamins in Phase I and Phase II drug metabolism. Read More

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http://dx.doi.org/10.2174/1573402114666180613080439DOI Listing
January 2019
30 Reads

Arterial Hypertension and Multiple Myeloma: Physiopathology and Cardiovascular Risk and 'Practical' Indications in Patients Receiving Carfilzomib.

Curr Hypertens Rev 2019 ;15(1):47-53

Internal Medicine and Hypertension Division, Department of Medical Sciences, AOU Citta della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

The introduction of carfilzomib in the treatment of relapsing and refractory multiple myeloma has allowed a significant increase in survival. The most frequent adverse effect of Carfilzomib treatment is arterial hypertension, even though the exact physiopathological mechanism are still unclear. MM patients, on the other hand, often present significant cardiovascular risk factors and comorbidities. Read More

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http://dx.doi.org/10.2174/1573402114666180611110547DOI Listing
January 2019
1 Read

Ambulatory blood pressure monitoring in type 2 diabetes mellitus: a cross-sectional study.

Curr Hypertens Rev 2018 06 6. Epub 2018 Jun 6.

Department of General Medicine, Eastern Health, Melbourne, Australia.

Background: Ambulatory blood pressure (ABP) monitoring in type 2 diabetes (T2DM) is not yet routine in clinical practice.

Objectives: To quantify abnormal ABP patterns and their associations with diabetic complications, and to assess the reliability of office blood pressure (OBP) for assessing BP in T2DM.

Methods: In a cross-sectional study, eligible patients with T2DM underwent OBP and 24- hour ABP measurements under standardized conditions and screening for diabetic complications. Read More

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http://dx.doi.org/10.2174/1573402114666180607090205DOI Listing
June 2018
22 Reads

Cell-Free Fetal DNA: A Novel Biomarker for Early Prediction of Pre-eclampsia and Other Obstetric Complications.

Curr Hypertens Rev 2019 ;15(1):57-63

Department of Physiology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India, Postal Address: House No. 168, Kaveri Kunj, Phase II, Kamla Nagar-282005, Agra, Uttar Pradesh, India.

Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged as a promising biomarker for the prediction of pre-eclampsia. Read More

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http://dx.doi.org/10.2174/1573402114666180516131832DOI Listing
January 2019
5 Reads

Cardiovascular Effects of Liraglutide.

Authors:
Nasser Mikhail

Curr Hypertens Rev 2019 ;15(1):64-69

David-Geffen School of Medicine, OliveView-UCLA Medical Center, 14445 Olive View Dr, Sylmar, CA 91342, United States.

Background: Liraglutide is a glucagon-like 1 (GLP-1) agonist approved for treatment of type 2 diabetes and obesity.

Objective: To review the cardiovascular effects of liraglutide including macrovascular and microvascular events, its use in heart failure, and its effects on heart rate and blood pressure.

Results: The impact of liraglutide on cardiovascular outcomes was examined in a large welldesigned study published in 2016, the LEADER trial. Read More

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http://dx.doi.org/10.2174/1573402114666180507152620DOI Listing
January 2019
2 Reads

Should all Hypertensive Patients be Screened for Primary Aldosteronism?

Curr Hypertens Rev 2019 ;15(1):54-56

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.

Primary aldosteronism (PA) is not only a leading cause of secondary and resistant hypertension, but is also quite frequent in unselected hypertensive patients. Moreover, PA is associated with increased cardiovascular risk, which is disproportionate to BP levels. In addition, timely diagnosis of PA and prompt initiation of treatment attenuate this increased risk. Read More

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http://dx.doi.org/10.2174/1573402114666180507153549DOI Listing
January 2019
2 Reads

Pharmacological Treatment of Hypertension: Effects in Endothelial Function.

Curr Hypertens Rev 2018 ;14(2):123-127

Colegio Panamericano del Endotelio, Colombia and Facultad de Ciencias de la Salud Eugenio Espejo, UTE, Quito, Ecuador.

The vascular endothelium plays an important role to maintain the functional integrity of the cardiovascular system. The synthesis and secretion of substances with biological activity such as prostacyclin and NO give endothelium the vasodilator, antithrombotic, and antiatherosclerotic properties. Endothelial dysfunction participates in the genesis of HTA, but also hypertension produces endothelial damage. Read More

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http://dx.doi.org/10.2174/1573402114666180508104828DOI Listing
January 2018
1 Read

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach).

Curr Hypertens Rev 2018 ;14(2):76-85

Cardiovascular Engineering Lab, GIBIO, Universidad Tecnologica Nacional, Buenos Aires, Argentina.

This paper illustrates the evolution of our knowledge of arterial mechanics from our initial research works up to the present time. Several techniques focusing on this topic in terms of our experience are discussed. An interdisciplinary team composed by different institutions from Argentina, Uruguay, France and Spain was created to conduct research, to train human resources and to fulfill the inevitable social role of gaining access to technological innovation to improve public health. Read More

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http://www.eurekaselect.com/161478/article
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http://dx.doi.org/10.2174/1573402114666180423110658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416192PMC
January 2018
4 Reads

Azilsartan and Chlorthalidone-new Powerful Fixed dose Antihypertensive Combination.

Curr Hypertens Rev 2018 ;14(1):15-20

1st Cardiology Department, Athens Medical School, University of Athens, "Hippokration" Hospital, Athens, Greece.

Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and οnly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Read More

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http://dx.doi.org/10.2174/1573402114666180420170816DOI Listing
April 2019
5 Reads

Effects of Transcutaneous Electrical Nerve Stimulation in Autonomic Nervous System of Hypertensive Patients: A Randomized Controlled Trial.

Curr Hypertens Rev 2018 ;14(1):66-71

Universidade Federal de Ciencias da Saude de Porto Alegre-UFCSPA, Porto Alegre-RS, Brazil.

Background: Patients with hypertension have altered autonomic nervous system function, which are increased sympathetic activity. Transcutaneous Electrical Nerve Stimulation (TENS) is a useful modality for pain control and has also been shown to be effective in the reduction of sympathetic activity in healthy subjects and individuals with cardiovascular diseases.

Objective: The aim of this study was to verify the effects of transcutaneous electrical nerve stimulation by the evaluation of heart rate variability (HRV) in patients with essential hypertension. Read More

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http://dx.doi.org/10.2174/1573402114666180416155528DOI Listing
April 2019
4 Reads

Hypertension and Aortic Stenosis: A Review.

Curr Hypertens Rev 2018 ;14(1):6-14

Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.

Background: Aortic stenosis is a common form of valvular heart disease which often coexists with hypertension. These diseases represent two distinct forms of left ventricular systolic overload and in combination may be associated with disadvantageous left ventricular remodeling, increased mortality and heart failure. The treatment of hypertension in aortic stenosis remains a challenging problem with limited data to guide clinical practice. Read More

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http://dx.doi.org/10.2174/1573402114666180416161326DOI Listing
April 2019
2 Reads

A Systematic Review of First Trimester Biochemical and Molecular Predictive Tests for Preeclampsia.

Curr Hypertens Rev 2018 ;14(1):21-28

Social Determinants of Health Research Centre (SDH), Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first-trimester screening tests for preeclampsia.

Methods: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases. Read More

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http://dx.doi.org/10.2174/1573402114666180416160425DOI Listing
April 2019
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Central-To-Peripheral Arterial Stiffness Gradient in Hemodialyzed Patients Depends on the Location of the Upper-limb Vascular Access.

Curr Hypertens Rev 2018 ;14(2):128-136

Instituto de Medicina Traslacional, Trasplante y Bioingenieria (IMeTTyB), Universidad Favaloro-CONICET, Solis 453, C1078AAI Buenos Aires, Argentina.

Background: Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained on the side of the body where the VA was placed and compare them to its contralateral intact side. Read More

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http://dx.doi.org/10.2174/1573402114666180413122055DOI Listing
January 2018
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Arterial Stiffness in Haemodialyzed Patients: Findings and Controversies.

Curr Hypertens Rev 2018 ;14(2):100-106

Physiology Department, School of Medicine, Centro Universitario de Investigacion, Innovacion y Diagnostico Arterial (CUiiDARTE), Republic University, Montevideo, Uruguay.

Vascular research in end-stage renal diseases is an interesting field in which the characterization of arterial stiffness proved to be valuable to predict morbidity and mortality. Particularly, patients on renal replacement therapy have been reported to have significant increases in arterial stiffness and cardiovascular mortality. The clinical relevance of the measurement of arterial stiffness is linked to therapeutical and preventive interventions. Read More

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http://dx.doi.org/10.2174/1573402114666180413115431DOI Listing
January 2018
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Serum Uric Acid Elevation is Associated to Arterial Stiffness in Hypertensive Patients with Metabolic Disturbances.

Curr Hypertens Rev 2018 ;14(2):154-160

Arterial Hypertension and Metabolic Unit, University Hospital - Favaloro Foundation, Belgrano 1782 P: 4 (1093), Buenos Aires, Argentina.

Introduction: Chronic serum uric acid elevation (SUA) is known to be induced by dyslipidemia, hypertension, inflammation, and insulin resistance. Therefore, it has been associated with higher risk for coronary artery disease and cardiovascular mortality. Also, increased levels of SUA have been associated with regional arterial stiffness, assessed by pulse wave velocity (PWV). Read More

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http://dx.doi.org/10.2174/1573402114666180413143312DOI Listing
January 2018
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Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Clinical Approach).

Curr Hypertens Rev 2018 ;14(2):86-94

Cardiovascular Engineering Lab, GIBIO, Universidad Tecnologica Nacional, Buenos Aires, Argentina.

To enhance the efficiency of patient-specific risk stratification and diagnosis, an assessment of arterial structural and functional changes associated to a vascular disease in both early and advanced stages have been proposed, with the objective of limiting the progression or revert vascular alterations. In this connection, an interdisciplinary international partnership made up by research institutions from France, Argentina, Uruguay and Spain was established, with the objective of contributing to the evaluation and follow-up of factors involved in the physiopathology of cardiometabolic diseases and human aging. Several studies, such as the effect of hypertension in large arteries, alterations in arterial wall viscosity, stiffness and inertia, endothelial function and vascular reactivity, cardiovascular risk improvement, vascular age assessment and cryografts vascular response evaluation were carried out as a result of this international collaboration during the last twenty-five years. Read More

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http://dx.doi.org/10.2174/1573402114666180413144119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142407PMC
January 2018
2 Reads

Increases in Peripheral Systolic Pressure Levels and Z-score Associate Gradual Aortic Pressure Increase and Functional Arterial Impairment in Children and Adolescents.

Curr Hypertens Rev 2018 ;14(2):170-182

Physiology Department, Faculty of Medicine, Centro Universitario de Investigacion, Innovacion y Diagnóstico Arterial (CUiiDARTE), Republic University, Montevideo, Uruguay.

Background: Arterial changes associated with children and adolescents high blood pressure (HBP) states would vary depending on the arterial type, arterial indexes considered and/or on blood pressure (BP) levels.

Aims: To determine in children and adolescents: 1) if there is gradual structural-functional arterial impairment associated with gradual peripheral (brachial) systolic BP (pSBP) level or z-score increases, and 2) whether subjects with HBP levels and those with normal BP differ in the profiles of arterial changes associated with pSBP deviations.

Methods: 1005 asymptomatic children and adolescents were included. Read More

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http://dx.doi.org/10.2174/1573402114666180413141509DOI Listing
January 2018
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Forward and Backward Aortic Components and Reflection Indexes in Children and Adolescents: Determinants and Role in High Pressure States.

Curr Hypertens Rev 2018 ;14(2):137-153

Physiology Department, Faculty of Medicine, Centro Universitario de Investigacion, Innovacion y Diagnostico Arterial (CUiiDARTE), Republic University, Montevideo, Uruguay.

Background: High blood pressure states (HBP) would differ in wave components and reflections indexes, which could associate clinical and prognostic implications. The study aims: 1) to characterize the association of aortic wave components and reflection parameters (backward [Pb], forward [Pf], Pb/Pf ratio and augmentation index [AIx]) with demographic, anthropometric, hemodynamic and arterial parameters in healthy children and adolescents; 2) to generate multivariate prediction models for the associations, to contribute to understand the main determinants of Pf, Pb, Pb/Pf and AIx; 3) to identify if differences in wave reflection indexes observed in HBP could be explained by differences in the analyzed parameters.

Methods: Healthy children and adolescents (n=816, females: 386; Age: 3-20 years) were studied. Read More

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http://dx.doi.org/10.2174/1573402114666180413113910DOI Listing
January 2018
16 Reads