1,773 results match your criteria Current Hypertension Reports [Journal]


Family Dynamics in Sleep Health and Hypertension.

Curr Hypertens Rep 2019 Apr 13;21(5):39. Epub 2019 Apr 13.

Department of Psychology, University of Alabama, Box 870348, Tuscaloosa, AL, 35487-0348, USA.

Purpose Of Review: Present a conceptual model and review the recent literature on family dynamics, sleep, and hypertension.

Recent Findings: Family dynamics predict hypertension and hypertension risk, in part, due to shared health behaviors. Sleep health behaviors (sleep duration, quality, and efficiency) predict hypertension risk in children and youth and are emerging as a family-level health behavior. Read More

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http://dx.doi.org/10.1007/s11906-019-0944-9DOI Listing
April 2019
4 Reads

The NaK-ATPase Inhibitor Marinobufagenin and Early Cardiovascular Risk in Humans: a Review of Recent Evidence.

Curr Hypertens Rep 2019 Apr 12;21(5):38. Epub 2019 Apr 12.

Hypertension in Africa Research Team (HART), North-West University, Private Bag X1290, Potchefstroom, 2520, South Africa.

Purpose Of Review: This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na/K-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular risk markers.

Recent Findings: Twenty-four-hour urinary MBG strongly associates with habitual salt intake in young healthy adults (aged 20-30 years). Furthermore, in young healthy adults free of detected cardiovascular disease, MBG associates with increased large artery stiffness and left ventricular mass independent of blood pressure. Read More

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http://dx.doi.org/10.1007/s11906-019-0942-yDOI Listing

Sleep and Resistant Hypertension.

Curr Hypertens Rep 2019 Apr 5;21(5):34. Epub 2019 Apr 5.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Purpose Of Review: The goal of the present review is to describe the current findings on the association of sleep with resistant hypertension (hypertension that remains uncontrolled despite the use of three or more antihypertensive medications from different classes, including a diuretic).

Recent Findings: Sleep disturbances, particularly obstructive sleep apnea (OSA), are highly prevalent among adults who have resistant hypertension. Randomized controlled trials indicate that treating OSA has modest effects on blood pressure lowering among those with the highest initial blood pressure. Read More

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http://link.springer.com/10.1007/s11906-019-0941-z
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http://dx.doi.org/10.1007/s11906-019-0941-zDOI Listing
April 2019
5 Reads

Comparison of Cardiovascular Benefits of Bariatric Surgery and Abdominal Lipectomy.

Authors:
Petra Rocic

Curr Hypertens Rep 2019 Apr 5;21(5):37. Epub 2019 Apr 5.

Department of Pharmacology, New York Medical College, BSB 502, 15 Dana Road, Valhalla, NY, 10595, USA.

Purpose Of Review: The purpose of this review is to examine recent evidence supporting effectiveness of bariatric surgery and abdominal lipectomy as interventional strategies aimed at reduction in incidence of cardiovascular disease (CVD) and related morbidity and mortality in obese and metabolic syndrome patients.

Recent Findings: While several studies show reduction in CVD risk factors in patients who have undergone both the Roux-en-Y gastric bypass and sleeve gastrectomy, very few demonstrate actual improvements in cardiovascular function, or a decrease in CVD events or CVD-related mortality. Consequently, the cardiovascular benefits of the less invasive sleeve gastrectomy in comparison to the gastric bypass are also unclear. Read More

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http://dx.doi.org/10.1007/s11906-019-0945-8DOI Listing
April 2019
1 Read

Sleep Duration and Blood Pressure: Recent Advances and Future Directions.

Curr Hypertens Rep 2019 Apr 5;21(5):33. Epub 2019 Apr 5.

Department of Medicine, Division of Cardiology, Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center, 622 West 168th Street, PH 9-321, New York, NY, 10032, USA.

Purpose Of Review: This review discusses the recent literature on subjectively and objectively assessed sleep duration in relation to hypertension risk and out-of-clinic blood pressure (BP) measures and highlights critical areas for future research.

Recent Findings: Sleep duration, particularly short sleep, may influence BP through disturbed autonomic balance, hormonal imbalances, increased adiposity and metabolic dysfunction, and disrupted circadian rhythms. Observational studies indicate that short and long sleep are associated with hypertension risk, reduced nocturnal dipping, and elevated morning BP, but evidence is stronger for short sleep. Read More

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http://dx.doi.org/10.1007/s11906-019-0938-7DOI Listing

Epicardial Adipose Tissue and Cardiovascular Disease.

Curr Hypertens Rep 2019 Apr 5;21(5):36. Epub 2019 Apr 5.

Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Purpose Of Review: Epicardial adipose tissue has been associated with the development/progression of cardiovascular disease. We appraise the strength of the association between epicardial adipose tissue and development/progression of cardiovascular diseases like coronary artery disease, atrial fibrillation, and heart failure with preserved ejection fraction.

Recent Findings: Cross-sectional clinical and translational correlative studies have established an association between epicardial adipose tissue and progression of coronary artery disease. Read More

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http://dx.doi.org/10.1007/s11906-019-0939-6DOI Listing
April 2019
2 Reads

Implications of the 2017 AAP Clinical Practice Guidelines for Management of Hypertension in Children and Adolescents: a Review.

Curr Hypertens Rep 2019 Apr 5;21(5):35. Epub 2019 Apr 5.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.

Purpose Of Review: To evaluate the impact of the 2017 American Academy of Pediatrics Clinical Practice Guideline (2017 AAP CPG) for Screening and Management of High Blood Pressure in Children and Adolescents.

Recent Findings: The 2017 AAP CPG had several significant changes compared to the 2004 Fourth Report. This review will focus on the emerging evidence from the first studies to apply the 2017 AAP CPG and the simplified table it contains on the overall prevalence of HTN and on recognition among children and adolescents at a higher cardiovascular risk. Read More

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http://dx.doi.org/10.1007/s11906-019-0943-xDOI Listing
April 2019
3 Reads

Obstructive Sleep Apnea and Hypertension: Why Treatment Does Not Consistently Improve Blood Pressure.

Curr Hypertens Rep 2019 Apr 4;21(4):30. Epub 2019 Apr 4.

Sleep Disorder Centre, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Ospedale San Luca, Via Magnasco, 2, Milan, Italy.

Purpose Of Review: Obstructive sleep apnea (OSA) and hypertension are two phenomena deeply linked together and, although a causal relationship has been suggested, a recent meta-analysis showed only a very modest effect of OSA treatment on blood pressure (BP). However, a vast number of randomized controlled trials published so far share some limitations, mainly of methodological nature: neither OSA nor BP is always assessed in a standardized way. Moreover, compliance with OSA treatment is often sub-optimal making the results of these trials difficult to interpret. Read More

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http://dx.doi.org/10.1007/s11906-019-0935-xDOI Listing
April 2019
3 Reads

Automated Office-Based Blood Pressure Measurement: an Overview and Guidance for Implementation in Primary Care.

Curr Hypertens Rep 2019 Apr 4;21(4):29. Epub 2019 Apr 4.

Center for Health Equity, Johns Hopkins University, Baltimore, MD, 21205, USA.

Purpose Of Review: The purposes of this study are to review evidence supporting the use of automated office blood pressure (AOBP) measurement and to provide practical guidance for implementing it in clinical settings.

Recent Findings: Mean AOBP readings correlate with awake ambulatory blood pressure monitor (ABPM) values and predict cardiovascular outcomes better than conventional techniques. However, heterogeneity among readings suggests that AOBP does not replace ABPM. Read More

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http://dx.doi.org/10.1007/s11906-019-0936-9DOI Listing
April 2019
1 Read

Revisiting the Brain Renin-Angiotensin System-Focus on Novel Therapies.

Curr Hypertens Rep 2019 Apr 4;21(4):28. Epub 2019 Apr 4.

Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

Purpose Of Review: Although an independent brain renin-angiotensin system is often assumed to exist, evidence for this concept is weak. Most importantly, renin is lacking in the brain, and both brain angiotensinogen and angiotensin (Ang) II levels are exceptionally low. In fact, brain Ang II levels may well represent uptake of circulating Ang II via Ang II type 1 (AT) receptors. Read More

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http://dx.doi.org/10.1007/s11906-019-0937-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449495PMC

Masked Hypertension: Whom and How to Screen?

Curr Hypertens Rep 2019 Apr 4;21(4):26. Epub 2019 Apr 4.

Division of Cardiology, Center for Behavioral Cardiovascular Health, Columbia University Medical Center, 622 West 168th Street, PH 9-310, New York, NY, 10032, USA.

Purpose Of Review: To review issues regarding the practical implementation of screening strategies for masked hypertension.

Recent Findings: Masked hypertension has been associated with an increased risk of cardiovascular disease events and all-cause mortality. Recent guidelines have encouraged practitioners to use out-of-clinic monitoring to detect masked hypertension in some situations. Read More

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http://dx.doi.org/10.1007/s11906-019-0931-1DOI Listing
April 2019
1 Read

Hypertension and Pre-Hypertension Among Iranian Adults Population: a Meta-Analysis of Prevalence, Awareness, Treatment, and Control.

Curr Hypertens Rep 2019 Apr 4;21(4):27. Epub 2019 Apr 4.

Zahedan University of Medical Sciences, Hesabi St, Zahedan, Iran.

Purpose Of Review: This meta-analysis and systematic review was conducted to evaluate hypertension and prehypertension prevalence, awareness, treatment, and control in Iranian adults population.

Recent Findings: In this study, six international and national databases were searched from inception until August 30, 2018. Forty-eight studies performed on 417,392 participants were included in the meta-analysis. Read More

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http://dx.doi.org/10.1007/s11906-019-0933-zDOI Listing

Microvascular Endothelial Dysfunction in Patients with Obesity.

Curr Hypertens Rep 2019 Apr 4;21(4):32. Epub 2019 Apr 4.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy.

Purpose Of Review: To examine the state of the art on the pathogenesis of endothelial dysfunction in the microcirculation of patients with obesity, focusing on the complex relationship between the consolidated and the novel mechanisms involved in this alteration.

Recent Findings: Human obesity is associated with vascular endothelial dysfunction, caused by a reduced nitric oxide availability secondary to an enhanced oxidative stress production. Pro-inflammatory cytokine generation, secreted by perivascular adipose tissue, is a major mechanism whereby obesity is associated with a reduced vascular NO availability. Read More

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http://dx.doi.org/10.1007/s11906-019-0930-2DOI Listing
April 2019
1 Read

Pathogenesis of Familial Hyperaldosteronism Type II: New Concepts Involving Anion Channels.

Curr Hypertens Rep 2019 Apr 4;21(4):31. Epub 2019 Apr 4.

Department of Nephrology and Medical Intensive Care, BCRT, Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Berlin, Germany.

Purpose Of Review: The application of advanced genetic techniques has recently begun to unravel the genetic basis for familial primary aldosteronism type 2 (FH-II).

Recent Findings: Whole-exome sequencing in a large family with FH-II revealed a shared rare damaging heterozygous variant in CLCN2 (chr.3: g. Read More

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http://link.springer.com/10.1007/s11906-019-0934-y
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http://dx.doi.org/10.1007/s11906-019-0934-yDOI Listing
April 2019
1 Read

Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis.

Curr Hypertens Rep 2019 Apr 3;21(3):25. Epub 2019 Apr 3.

Instituto de Cardiologia do RS - Fundação Universitária de Cardiologia (IC-FUC), Av. Princesa Isabel, 370, 3rd floor, Bairro Santana, Porto Alegre, RS, 90620-000, Brazil.

Purpose Of Review: We aimed to evaluate the prevalence of sexual dysfunction in hypertensive women and compare sexual dysfunction between hypertensive and non-hypertensive women.

Recent Findings: Conducted a systematic review in the following databases: PubMed, EMBASE, Scopus, Web of Science, IBECS, and Lilacs. We included articles evaluating the prevalence of sexual dysfunction in a woman and/or comparing sexual dysfunction between hypertensive and non-hypertensive women. Read More

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http://dx.doi.org/10.1007/s11906-019-0925-zDOI Listing
April 2019
1 Read

Management of Hypertension in the Obese Pregnant Patient.

Curr Hypertens Rep 2019 Mar 26;21(3):24. Epub 2019 Mar 26.

Fetal Medicine Unit, St George's Hospital, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.

Purpose Of Review: To evaluate recent developments in the management of hypertension in obese pregnant women.

Recent Findings: The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pre-eclampsia from before 16 weeks' gestation. There are conflicting results regarding the use of metformin in reducing hypertensive disease, but there is a high probability that it has a role to play. Read More

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http://dx.doi.org/10.1007/s11906-019-0927-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435623PMC
March 2019
2 Reads

Emerging Therapy in Hypertension.

Curr Hypertens Rep 2019 Mar 2;21(3):23. Epub 2019 Mar 2.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.

Purpose Of The Review: Pharmacology remains the mainstay of treatment for hypertension across the globe. In what may seem like a well-trodden field, there are actually an exciting array of new pathways for the treatment of hypertension on the horizon. This review seeks to discuss the most recent research in ongoing areas of drug development in the field of hypertension. Read More

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http://dx.doi.org/10.1007/s11906-019-0923-1DOI Listing
March 2019
3 Reads

Eplerenone Versus Spironolactone in Resistant Hypertension: an Efficacy and/or Cost or Just a Men's Issue?

Curr Hypertens Rep 2019 Mar 2;21(3):22. Epub 2019 Mar 2.

Third Department of Cardiology, Athens University School of Medicine, Vas. Sofias 114, 115 27, Athens, Greece.

Purpose Of Review: To review comparative efficacy and tolerability data between the two main mineralocorticoid receptor antagonists (MRAs), spironolactone and eplerenone, in patients with resistant hypertension (HTN). The focus was whether spironolactone, being the classical non-selective agent that has been used for years, albeit with several anti-androgenic side effects, can be rivaled by eplerenone, an apparently weaker, but better tolerated, more selective MRA.

Recent Findings: Evidence has accumulated that resistant HTN is generally volume-dependent, attributable to varying degrees of aldosterone excess with its attendant renal effects of sodium and fluid retention. Read More

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http://dx.doi.org/10.1007/s11906-019-0924-0DOI Listing
March 2019
1 Read

Increased Risk of Hypertension in Young Adults in Southwest China: Impact of the 2017 ACC/AHA High Blood Pressure Guideline.

Curr Hypertens Rep 2019 Feb 28;21(3):21. Epub 2019 Feb 28.

Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Purpose Of Review: To examine the impact of the new 2017 ACC/AHA hypertension guideline on the prevalence of hypertension, its constituent ratio, and their associated factors in southwest China.

Recent Findings: A total of 14,220 permanent residents ≥ 18 years were enrolled in this survey. According to the 2017 ACC/AHA hypertension guideline, the hypertension prevalence was substantially increased (46. Read More

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http://dx.doi.org/10.1007/s11906-019-0926-yDOI Listing
February 2019
1 Read

The Role of Arterial Hypertension in Mitral Valve Regurgitation.

Curr Hypertens Rep 2019 Feb 28;21(3):20. Epub 2019 Feb 28.

First Department of Cardiology, 'Hippokration' Hospital, University of Athens, Medical School, 21 Orfanidou Street, 11142, Athens, Greece.

Purpose Of Review: To review medical literature for evidence of association between hypertension and mitral regurgitation (MR) and summarize potential favorable effects of antihypertensive drugs on MR natural history and treatment.

Recent Findings: Hypertension and MR are common diseases affecting a large proportion of the general population. Contemporary evidence suggests that hypertension may worsen the progression and prognosis of MR through augmented mechanical stress and increased regurgitation volume. Read More

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http://dx.doi.org/10.1007/s11906-019-0928-9DOI Listing
February 2019
2 Reads

Incorporation of Novel Vascular Measures into Clinical Management: Recent Insights from the Framingham Heart Study.

Curr Hypertens Rep 2019 Feb 21;21(2):19. Epub 2019 Feb 21.

Cardiovascular Engineering, Inc., 1 Edgewater Drive, Suite 201A, Norwood, MA, 02062, USA.

Purpose Of Review: The review discusses evidence from the Framingham Heart Study that supports the assessment and utility of novel vascular and blood pressure measures to inform clinical management of blood pressure-related cardiovascular disease.

Recent Findings: Recent Framingham Heart Study investigations provide new insights into the associations of novel and traditional vascular and blood pressure measures, such as measures of aortic stiffness, components of blood pressure waves, and orthostatic change in blood pressure, with cardiovascular disease events and brain structure and function. Novel vascular measures provide opportunities for additional investigation and potential development of new interventions that are more precisely targeted at underlying pathophysiology. Read More

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http://dx.doi.org/10.1007/s11906-019-0919-xDOI Listing
February 2019
1 Read

Weight Loss Medications in the Treatment of Obesity and Hypertension.

Curr Hypertens Rep 2019 Feb 12;21(2):16. Epub 2019 Feb 12.

Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.

Purpose Of Review: Weight loss is strongly associated with improvement in blood pressure; however, the mechanism of weight loss can impact the magnitude and sustainability of blood pressure reduction.

Recent Findings: Five drugs-orlistat, lorcaserin, liraglutide, phentermine/topiramate, and naltrexone/bupropion-are currently approved for weight loss therapy in the USA. Naltrexone/bupropion results in an increase in in-office and ambulatory blood pressure compared to placebo. Read More

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http://dx.doi.org/10.1007/s11906-019-0915-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415530PMC
February 2019
5 Reads

Implementing Home Blood Pressure Monitoring into Clinical Practice.

Curr Hypertens Rep 2019 Feb 12;21(2):14. Epub 2019 Feb 12.

Center for Behavioral Cardiovascular Health, Columbia University Medical Center, 622 W.168th Street, PH9-311, New York, NY, 10032, USA.

Purpose Of Review: To review data supporting the use of home blood pressure monitoring (HBPM) and provide practical guidance to clinicians wishing to incorporate HBPM into their practice.

Recent Findings: HBPM more accurately reflects the risk of cardiovascular events than office blood pressure measurement. In addition, there is high-quality evidence that HBPM combined with clinical support improves blood pressure control. Read More

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http://dx.doi.org/10.1007/s11906-019-0916-0DOI Listing
February 2019
2 Reads

Dietary Fat and Blood Pressure.

Authors:
Paul J Nestel

Curr Hypertens Rep 2019 Feb 12;21(2):17. Epub 2019 Feb 12.

Baker Heart and Diabetes Institute, Melbourne, Australia.

Purpose Of Review: Do dietary fats lower blood pressure? This review covers total fats, individual fatty acids and foods that provide specific fats.

Recent Findings: Evidence for blood pressure lowering is stronger for supplements providing individual marine fatty acids than for fish intake since data on fish consumption are scarce. Such effects are more readily apparent in hypertensive than normal subjects. Read More

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http://dx.doi.org/10.1007/s11906-019-0918-yDOI Listing
February 2019
6 Reads

Personalized Medicine and the Treatment of Hypertension.

Curr Hypertens Rep 2019 Feb 12;21(2):13. Epub 2019 Feb 12.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, 5570C MSRB II, 1150 West Medical Center Drive, SPC 5678, Ann Arbor, MI, 48109-5678, USA.

Purpose Of Review: The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension, including resistant hypertension.

Recent Findings: We suggest a framework for the personalized treatment of hypertension based on the concept of a trade-off between simplicity and personalization. This framework is based on treatment strategies classified as low, medium, or high information burden personalization approaches. Read More

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http://dx.doi.org/10.1007/s11906-019-0921-3DOI Listing
February 2019
10 Reads

Blood Pressure Lowering and Sodium-Glucose Co-transporter 2 Inhibitors (SGLT2is): More Than Osmotic Diuresis.

Curr Hypertens Rep 2019 Feb 12;21(2):12. Epub 2019 Feb 12.

AHA Comprehensive Hypertension Center, Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, The University of Chicago Medicine, 5841 S. Maryland Ave. MC 1027, Chicago, IL, 60637, USA.

Purpose Of Review: This is an update of data regarding changes in blood pressure using sodium-glucose co-transporter 2 inhibitors (SGLT2i) for the treatment of diabetes. The mechanism of blood pressure lowering by SGLT2i was thought to be due to their osmotic diuretic effects. New data, however, has emerged from meta-analyses and studies of people with impaired kidney function demonstrating similar or greater magnitudes of blood pressure reduction in the absence of significant glycosuria. Read More

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http://dx.doi.org/10.1007/s11906-019-0920-4DOI Listing
February 2019
4 Reads

Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.

Curr Hypertens Rep 2019 Feb 12;21(2):18. Epub 2019 Feb 12.

Division of Pediatric Nephrology, Johns Hopkins University, David M. Rubenstein Child Health Building, 200 N. Wolfe Street, Baltimore, MD, 21287, USA.

Purpose Of Review: To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity.

Recent Findings: Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbingly, this rising prevalence has been paralleled by an increase in cardiovascular disease (CVD) risk factors in childhood such as hypertension, dyslipidemia, and diabetes that become manifest earlier than previously reported. Read More

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http://dx.doi.org/10.1007/s11906-019-0922-2DOI Listing
February 2019
3 Reads

Four-Limb Blood Pressure Measurement with an Oscillometric Device: a Tool for Diagnosing Peripheral Vascular Disease.

Curr Hypertens Rep 2019 Feb 12;21(2):15. Epub 2019 Feb 12.

Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, 330006, NO 1 Mingde Road, Nanchang, Jiangxi, China.

Purpose Of Review: Traditionally, the term peripheral vascular disease (PAD) is restricted to the occlusive arterial disease in the leg, but now, the connotation of PAD is more widespread as it encompasses all extracoronary and extracerebral vascular disease. The incidence of PAD is increasing worldwide; therefore, it is necessary to diagnose PAD at an early stage.

Recent Findings: Oscillometric BP device is widely used for four-limb measurement in clinical practice and provides several parameters for evaluating inter-limb BP difference, such as ankle-brachial index (OS-ABI), inter-arm BP differences (IAD), and inter-ankle BP difference (IAND). Read More

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http://dx.doi.org/10.1007/s11906-019-0917-zDOI Listing
February 2019
6 Reads

A Meta-analysis to Determine the Validity of Taking Blood Pressure Using the Indirect Cuff Method.

Curr Hypertens Rep 2019 Feb 7;21(1):11. Epub 2019 Feb 7.

Department of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, 231 Turner Center, University, MS, 38677, USA.

Purpose Of Review: The purpose of this meta-analysis was to compare the magnitude of systematic bias (mean difference) and random error (standard deviation of mean difference) between the cuff method of indirect blood pressure and directly measured intra-arterial pressure.

Recent Findings: Blood pressure is almost exclusively assessed using the indirect cuff method; however, numerous individual studies have questioned the validity relative to directly measured intra-arterial blood pressure. PubMed, SportsDiscus, and Scopus were searched through February 2018. Read More

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http://dx.doi.org/10.1007/s11906-019-0929-8DOI Listing
February 2019
1 Read

Autoimmune Disease-Associated Hypertension.

Curr Hypertens Rep 2019 Feb 2;21(1):10. Epub 2019 Feb 2.

Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA.

Purpose Of Review: To highlight important new findings on the topic of autoimmune disease-associated hypertension.

Recent Findings: Autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are associated with an increased risk for hypertension and cardiovascular disease. A complex interaction among genetic, environmental, hormonal, and metabolic factors contribute to autoimmune disease susceptibility while promoting chronic inflammation that can lead to alterations in blood pressure. Read More

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http://dx.doi.org/10.1007/s11906-019-0914-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394456PMC
February 2019
2 Reads

Management of "Hypertension" Based on Blood Pressure Level Versus an Absolute Cardiovascular Risk Approach.

Authors:
Mark Nelson

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St (Private Bag 23), Hobart, TAS, 7000, Australia.

Purpose Of Review: To address the tension between guideline recommendations and the evidence from clinical trials supporting them and clinician concerns of overtreatment of elevated blood pressure.

Recent Findings: Systolic Blood Pressure Intervention trial (SPRINT) demonstrated lower blood pressure targets provided robust clinical benefit (reduced all-cause mortality) but also expected adverse events due to hypotension. Treatment thresholds for systolic blood pressure in the latest US guidelines have been lowered to 130 mmHg, although this has not been adopted elsewhere. Read More

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http://dx.doi.org/10.1007/s11906-019-0912-4DOI Listing
January 2019
1 Read

Unanswered Questions Regarding Blood Pressure Management for HF Prevention.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02445, USA.

Purpose Of Review: Evaluate the relevant new findings regarding hypertension treatment and heart failure prevention published in the past 3 years.

Recent Findings: In a recent secondary analysis of Systolic Blood Pressure Intervention Trial (SPRINT), randomization of more than 9000 patients > 50 years old with high cardiovascular risk but without diabetes to intensive treatment targeting blood pressure < 120/80 mmHg compared to standard treatment targeting < 140/90 mmHg significantly reduced incident heart failure. While such benefits outweighed potential harm, adverse events including renal dysfunction, hypotension, and syncope occurred more frequently with intensive treatment. Read More

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http://dx.doi.org/10.1007/s11906-019-0908-0DOI Listing
January 2019
3 Reads

Antihypertensive Agents in the Dialysis Patient.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Division of Nephrology and Hypertension, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.

Purpose Of Review: Hypertension and antihypertensive drug utilization are remarkably prevalent in ESRD patients. Management of blood pressure elevation in this population is complicated by many factors, including a multidimensional etiology, challenges in obtaining accurate and appropriately timed blood pressure measurements, highly specific drug dosing requirements, and a paucity of outcomes-based evidence to guide management decisions. The purpose of this review is to summarize and apply knowledge from existing clinical trials to enhance safe and effective use of antihypertensive agents in dialysis patients. Read More

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http://dx.doi.org/10.1007/s11906-019-0909-zDOI Listing
January 2019
2 Reads

Innate and Innate-Like Immune System in Hypertension and Vascular Injury.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada.

Purpose Of Review: To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury.

Recent Findings: Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Read More

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http://dx.doi.org/10.1007/s11906-019-0907-1DOI Listing
January 2019
1 Read

Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose Of Review: Previous trials definitively established that lowering systolic blood pressure (BP) to 140 mmHg prevented heart failure (HF) exacerbations, but the potential benefits and risks of further BP reduction remain unclear due to a paucity of trial-based data.

Recent Findings: A recent secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) found that in older, high-risk, non-diabetic participants with systolic hypertension, a BP treatment target < 120 mmHg resulted in a 36% lower rate of acute decompensated HF as compared with a BP target < 140 mmHg. Those participants with incident HF had a 26-fold increased risk of subsequent cardiovascular events and death. Read More

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http://link.springer.com/10.1007/s11906-019-0913-3
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http://dx.doi.org/10.1007/s11906-019-0913-3DOI Listing
January 2019
6 Reads

A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202-2689, USA.

Purpose Of Review: In this review, we summarized the current knowledge of connecting tubule-glomerular feedback (CTGF), a novel mechanism of renal microcirculation regulation that integrates sodium handling in the connecting tubule (CNT) with kidney hemodynamics.

Recent Findings: Connecting tubule-glomerular feedback is a crosstalk communication between the CNT and the afferent arteriole (Af-Art), initiated by sodium chloride through the epithelial sodium channel (ENaC). High sodium in the CNT induces Af-Art vasodilation, increasing glomerular pressure and the glomerular filtration rate and favoring sodium excretion. Read More

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http://dx.doi.org/10.1007/s11906-019-0911-5DOI Listing
January 2019
2 Reads

Recent Advances in Imaging of Hypertensive Heart Disease.

Curr Hypertens Rep 2019 Jan 14;21(1). Epub 2019 Jan 14.

Department of Cardiology, University of Virginia, Charlottesville, VA, USA.

Purpose Of Review: To review recent advances in the imaging of hypertensive heart disease (HHD) with an emphasis on developments in the imaging of diffuse myocardial fibrosis using cardiac magnetic resonance (CMR).

Recent Findings: HHD results from long-standing hypertension and is characterized by the development of left ventricular hypertrophy and diffuse interstitial fibrosis. Diffuse fibrosis traditionally required endomyocardial biopsy to diagnose, but recent developments using T1 mapping in CMR allow for noninvasive assessment. Read More

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http://dx.doi.org/10.1007/s11906-019-0910-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400461PMC
January 2019
4 Reads

Impact of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia.

Curr Hypertens Rep 2019 Jan 10;21(1). Epub 2019 Jan 10.

Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, 078-8510, Japan.

Purpose Of Review: To estimate the impact of the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for high blood pressure (BP) on the next hypertension guidelines in Asia.

Recent Findings: The 2017 ACC/AHA guidelines for high BP in adults changed the diagnostic threshold and the management goal of BP from 140/90 to 130/80 mmHg. Another characteristic of the new guideline is its focus on a practical approach for the effective management of hypertension by using home and ambulatory BP monitoring; this point is also recommended in the 2014 Japanese Society of Hypertension Guidelines for the Management of Hypertension. Read More

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http://dx.doi.org/10.1007/s11906-019-0906-2DOI Listing
January 2019
2 Reads

Correction to: Chronotherapy for Hypertension.

Curr Hypertens Rep 2018 Dec 4;21(1). Epub 2018 Dec 4.

Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Rd. L606, Portland, OR, 97239, USA.

The meta-analysis referenced in the "Obstructive Sleep Apnea" section should instead refer to a meta-analysis for chronic kidney disease. Additionally, there are two mis-numbered reference citations in the "chronic kidney disease" section (ref. 107 should ref. Read More

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http://link.springer.com/10.1007/s11906-018-0905-8
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http://dx.doi.org/10.1007/s11906-018-0905-8DOI Listing
December 2018
3 Reads

The Mediterranean Diet: Lost in Translation.

Curr Hypertens Rep 2018 Nov 14;20(12):104. Epub 2018 Nov 14.

UCF College of Medicine, HCA GME Consortium Gainesville, Orlando, FL, USA.

Purpose Of Review: Despite substantive evidence documenting the efficacy of the Mediterranean diet to reduce cardiovascular events, underutilization is common. An overview of the data set supporting the role of the Mediterranean diet as confirmed in both observational and interventional trials should stimulate greater clinician interest in the diet. Additionally, the availability of patient-friendly tools that enable prompt and easy adoption of the Mediterranean diet, that are able to be used by clinicians who claim no special expertise in diet knowledge, should simplify the path to successful dietary change. Read More

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http://dx.doi.org/10.1007/s11906-018-0904-9DOI Listing
November 2018
6 Reads

Inflammation in Salt-Sensitive Hypertension and Renal Damage.

Curr Hypertens Rep 2018 Oct 30;20(12):103. Epub 2018 Oct 30.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, 27710, USA.

Purpose Of Review: Low-grade inflammation drives elevations in blood pressure (BP) and consequent target organ damage in diverse experimental models of hypertension. Here, we discuss recent advances elucidating immune-mediated mechanisms of BP elevation and associated target organ damage.

Recent Findings: Inflammatory mediators produced by immune cells or target organs act on the kidney, vasculature, skin, and nervous system to modulate hypertension. Read More

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http://link.springer.com/10.1007/s11906-018-0903-x
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http://dx.doi.org/10.1007/s11906-018-0903-xDOI Listing
October 2018
27 Reads

Out of Office Blood Pressure Measurement in Pregnancy and the Postpartum Period.

Curr Hypertens Rep 2018 Oct 25;20(12):101. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology and Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: Hypertensive disorders of pregnancy are increasing in prevalence and associated with significant maternal and perinatal morbidity and mortality.

Recent Findings: Increased emphasis has been placed recently on the use of out-of-office (i.e. Read More

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http://link.springer.com/10.1007/s11906-018-0901-z
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http://dx.doi.org/10.1007/s11906-018-0901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327956PMC
October 2018
7 Reads

The Relationship Between Psychosocial Status and Hypertensive Condition.

Curr Hypertens Rep 2018 Oct 25;20(12):102. Epub 2018 Oct 25.

Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Purpose Of Review: The aim of the paper is to test the influence of social status and psychological well-being (independent variables) on hypertensive condition (dependent variable), when adjusting for traditional risk factors of cardiovascular disease (control variables). The analysis is based on data collected from SEPHAR III, a nationally representative epidemiologic study of the Romanian adult population.

Recent Findings: Understanding the social roots of health issues is of considerable importance in developing effective strategies and policies. Read More

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http://link.springer.com/10.1007/s11906-018-0902-y
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http://dx.doi.org/10.1007/s11906-018-0902-yDOI Listing
October 2018
21 Reads

Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure.

Curr Hypertens Rep 2018 Oct 5;20(12):100. Epub 2018 Oct 5.

Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue, SL39, New Orleans, LA, 70112-2699, USA.

Purpose Of Review: Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of RAS components by pro-inflammatory factors.

Recent Findings: Angiotensin II (Ang II), which is produced by RAS, induces vasoconstriction and consequent blood pressure elevation. Read More

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http://dx.doi.org/10.1007/s11906-018-0900-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203444PMC
October 2018
2 Reads

Obesity and Pulmonary Hypertension.

Curr Hypertens Rep 2018 Oct 5;20(12):99. Epub 2018 Oct 5.

Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Purpose Of Review: Whether the present obesity epidemic will increase the prevalence of pulmonary hypertension over the next decades is unclear. We review the obesity-related mechanisms that may further the development and progression of pulmonary hypertension.

Recent Findings: Systemic and local inflammation, insulin resistance and oxidative stress contribute to the pathobiology of obesity and pulmonary arterial hypertension. Read More

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http://link.springer.com/10.1007/s11906-018-0899-2
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http://dx.doi.org/10.1007/s11906-018-0899-2DOI Listing
October 2018
5 Reads

Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials.

Curr Hypertens Rep 2018 Oct 3;20(11):98. Epub 2018 Oct 3.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose Of Review: Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressure.

Recent Finding: Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Read More

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https://www.researchgate.net/publication/327580357_Effect_of
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https://link.springer.com/journal/11906
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http://link.springer.com/10.1007/s11906-018-0898-3
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http://dx.doi.org/10.1007/s11906-018-0898-3DOI Listing
October 2018
4 Reads
3.440 Impact Factor

Chronotherapy for Hypertension.

Curr Hypertens Rep 2018 Sep 28;20(11):97. Epub 2018 Sep 28.

Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Rd. L606, Portland, OR, 97239, USA.

Purpose Of Review: Given the emerging knowledge that circadian rhythmicity exists in every cell and all organ systems, there is increasing interest in the possible benefits of chronotherapy for many diseases. There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events. Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk. Read More

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http://link.springer.com/10.1007/s11906-018-0897-4
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http://dx.doi.org/10.1007/s11906-018-0897-4DOI Listing
September 2018
24 Reads

Adipose Tissue and Modulation of Hypertension.

Curr Hypertens Rep 2018 Sep 18;20(11):96. Epub 2018 Sep 18.

Translational Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 0A4, Canada.

Purpose Of Review: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN. Read More

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http://dx.doi.org/10.1007/s11906-018-0894-7DOI Listing
September 2018
6 Reads
3.440 Impact Factor

SPRINT and the Kidney: What Have We Learned?

Curr Hypertens Rep 2018 Sep 14;20(11):95. Epub 2018 Sep 14.

Department of Medicine, University Hospitals Cleveland Medical Center, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH, 44106, USA.

Purpose Of Review: To review the impact of the Systolic Blood Pressure Interventional Trial (SPRINT) on renal function and chronic kidney disease.

Recent Findings: Hypertension is a risk factor for cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). The benefits of intensive blood pressure lowering in the CKD population in previous studies are unclear. Read More

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http://dx.doi.org/10.1007/s11906-018-0895-6DOI Listing
September 2018
20 Reads

Skin Sodium and Hypertension: a Paradigm Shift?

Curr Hypertens Rep 2018 Sep 13;20(11):94. Epub 2018 Sep 13.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Box 98, Addenbrookes Hospital, Cambridge, CB2 0QQ, UK.

Purpose Of Review: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role.

Recent Findings: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Read More

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http://dx.doi.org/10.1007/s11906-018-0892-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153561PMC
September 2018
2 Reads