1,752 results match your criteria Current Hypertension Reports [Journal]


Weight Loss Medications in the Treatment of Obesity and Hypertension.

Curr Hypertens Rep 2019 Feb 12;21(2):16. Epub 2019 Feb 12.

Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA.

Purpose Of Review: Weight loss is strongly associated with improvement in blood pressure; however, the mechanism of weight loss can impact the magnitude and sustainability of blood pressure reduction.

Recent Findings: Five drugs-orlistat, lorcaserin, liraglutide, phentermine/topiramate, and naltrexone/bupropion-are currently approved for weight loss therapy in the USA. Naltrexone/bupropion results in an increase in in-office and ambulatory blood pressure compared to placebo. Read More

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http://dx.doi.org/10.1007/s11906-019-0915-1DOI Listing
February 2019
2 Reads

Implementing Home Blood Pressure Monitoring into Clinical Practice.

Curr Hypertens Rep 2019 Feb 12;21(2):14. Epub 2019 Feb 12.

Center for Behavioral Cardiovascular Health, Columbia University Medical Center, 622 W.168th Street, PH9-311, New York, NY, 10032, USA.

Purpose Of Review: To review data supporting the use of home blood pressure monitoring (HBPM) and provide practical guidance to clinicians wishing to incorporate HBPM into their practice.

Recent Findings: HBPM more accurately reflects the risk of cardiovascular events than office blood pressure measurement. In addition, there is high-quality evidence that HBPM combined with clinical support improves blood pressure control. Read More

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http://dx.doi.org/10.1007/s11906-019-0916-0DOI Listing
February 2019
1 Read

Dietary Fat and Blood Pressure.

Authors:
Paul J Nestel

Curr Hypertens Rep 2019 Feb 12;21(2):17. Epub 2019 Feb 12.

Baker Heart and Diabetes Institute, Melbourne, Australia.

Purpose Of Review: Do dietary fats lower blood pressure? This review covers total fats, individual fatty acids and foods that provide specific fats.

Recent Findings: Evidence for blood pressure lowering is stronger for supplements providing individual marine fatty acids than for fish intake since data on fish consumption are scarce. Such effects are more readily apparent in hypertensive than normal subjects. Read More

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http://dx.doi.org/10.1007/s11906-019-0918-yDOI Listing
February 2019
1 Read

Personalized Medicine and the Treatment of Hypertension.

Curr Hypertens Rep 2019 Feb 12;21(2):13. Epub 2019 Feb 12.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, 5570C MSRB II, 1150 West Medical Center Drive, SPC 5678, Ann Arbor, MI, 48109-5678, USA.

Purpose Of Review: The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension, including resistant hypertension.

Recent Findings: We suggest a framework for the personalized treatment of hypertension based on the concept of a trade-off between simplicity and personalization. This framework is based on treatment strategies classified as low, medium, or high information burden personalization approaches. Read More

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http://dx.doi.org/10.1007/s11906-019-0921-3DOI Listing
February 2019
2 Reads

Blood Pressure Lowering and Sodium-Glucose Co-transporter 2 Inhibitors (SGLT2is): More Than Osmotic Diuresis.

Curr Hypertens Rep 2019 Feb 12;21(2):12. Epub 2019 Feb 12.

AHA Comprehensive Hypertension Center, Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, The University of Chicago Medicine, 5841 S. Maryland Ave. MC 1027, Chicago, IL, 60637, USA.

Purpose Of Review: This is an update of data regarding changes in blood pressure using sodium-glucose co-transporter 2 inhibitors (SGLT2i) for the treatment of diabetes. The mechanism of blood pressure lowering by SGLT2i was thought to be due to their osmotic diuretic effects. New data, however, has emerged from meta-analyses and studies of people with impaired kidney function demonstrating similar or greater magnitudes of blood pressure reduction in the absence of significant glycosuria. Read More

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http://dx.doi.org/10.1007/s11906-019-0920-4DOI Listing
February 2019
2 Reads

Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.

Curr Hypertens Rep 2019 Feb 12;21(2):18. Epub 2019 Feb 12.

Division of Pediatric Nephrology, Johns Hopkins University, David M. Rubenstein Child Health Building, 200 N. Wolfe Street, Baltimore, MD, 21287, USA.

Purpose Of Review: To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity.

Recent Findings: Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbingly, this rising prevalence has been paralleled by an increase in cardiovascular disease (CVD) risk factors in childhood such as hypertension, dyslipidemia, and diabetes that become manifest earlier than previously reported. Read More

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http://dx.doi.org/10.1007/s11906-019-0922-2DOI Listing
February 2019
2 Reads

Four-Limb Blood Pressure Measurement with an Oscillometric Device: a Tool for Diagnosing Peripheral Vascular Disease.

Curr Hypertens Rep 2019 Feb 12;21(2):15. Epub 2019 Feb 12.

Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, 330006, NO 1 Mingde Road, Nanchang, Jiangxi, China.

Purpose Of Review: Traditionally, the term peripheral vascular disease (PAD) is restricted to the occlusive arterial disease in the leg, but now, the connotation of PAD is more widespread as it encompasses all extracoronary and extracerebral vascular disease. The incidence of PAD is increasing worldwide; therefore, it is necessary to diagnose PAD at an early stage.

Recent Findings: Oscillometric BP device is widely used for four-limb measurement in clinical practice and provides several parameters for evaluating inter-limb BP difference, such as ankle-brachial index (OS-ABI), inter-arm BP differences (IAD), and inter-ankle BP difference (IAND). Read More

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http://dx.doi.org/10.1007/s11906-019-0917-zDOI Listing
February 2019

A Meta-analysis to Determine the Validity of Taking Blood Pressure Using the Indirect Cuff Method.

Curr Hypertens Rep 2019 Feb 7;21(1):11. Epub 2019 Feb 7.

Department of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, 231 Turner Center, University, MS, 38677, USA.

Purpose Of Review: The purpose of this meta-analysis was to compare the magnitude of systematic bias (mean difference) and random error (standard deviation of mean difference) between the cuff method of indirect blood pressure and directly measured intra-arterial pressure.

Recent Findings: Blood pressure is almost exclusively assessed using the indirect cuff method; however, numerous individual studies have questioned the validity relative to directly measured intra-arterial blood pressure. PubMed, SportsDiscus, and Scopus were searched through February 2018. Read More

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http://dx.doi.org/10.1007/s11906-019-0929-8DOI Listing
February 2019
1 Read

Autoimmune Disease-Associated Hypertension.

Curr Hypertens Rep 2019 Feb 2;21(1):10. Epub 2019 Feb 2.

Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA.

Purpose Of Review: To highlight important new findings on the topic of autoimmune disease-associated hypertension.

Recent Findings: Autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are associated with an increased risk for hypertension and cardiovascular disease. A complex interaction among genetic, environmental, hormonal, and metabolic factors contribute to autoimmune disease susceptibility while promoting chronic inflammation that can lead to alterations in blood pressure. Read More

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http://dx.doi.org/10.1007/s11906-019-0914-2DOI Listing
February 2019
1 Read

Management of "Hypertension" Based on Blood Pressure Level Versus an Absolute Cardiovascular Risk Approach.

Authors:
Mark Nelson

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St (Private Bag 23), Hobart, TAS, 7000, Australia.

Purpose Of Review: To address the tension between guideline recommendations and the evidence from clinical trials supporting them and clinician concerns of overtreatment of elevated blood pressure.

Recent Findings: Systolic Blood Pressure Intervention trial (SPRINT) demonstrated lower blood pressure targets provided robust clinical benefit (reduced all-cause mortality) but also expected adverse events due to hypotension. Treatment thresholds for systolic blood pressure in the latest US guidelines have been lowered to 130 mmHg, although this has not been adopted elsewhere. Read More

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http://dx.doi.org/10.1007/s11906-019-0912-4DOI Listing
January 2019
1 Read

Unanswered Questions Regarding Blood Pressure Management for HF Prevention.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02445, USA.

Purpose Of Review: Evaluate the relevant new findings regarding hypertension treatment and heart failure prevention published in the past 3 years.

Recent Findings: In a recent secondary analysis of Systolic Blood Pressure Intervention Trial (SPRINT), randomization of more than 9000 patients > 50 years old with high cardiovascular risk but without diabetes to intensive treatment targeting blood pressure < 120/80 mmHg compared to standard treatment targeting < 140/90 mmHg significantly reduced incident heart failure. While such benefits outweighed potential harm, adverse events including renal dysfunction, hypotension, and syncope occurred more frequently with intensive treatment. Read More

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http://dx.doi.org/10.1007/s11906-019-0908-0DOI Listing
January 2019
2 Reads

Antihypertensive Agents in the Dialysis Patient.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Division of Nephrology and Hypertension, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.

Purpose Of Review: Hypertension and antihypertensive drug utilization are remarkably prevalent in ESRD patients. Management of blood pressure elevation in this population is complicated by many factors, including a multidimensional etiology, challenges in obtaining accurate and appropriately timed blood pressure measurements, highly specific drug dosing requirements, and a paucity of outcomes-based evidence to guide management decisions. The purpose of this review is to summarize and apply knowledge from existing clinical trials to enhance safe and effective use of antihypertensive agents in dialysis patients. Read More

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http://dx.doi.org/10.1007/s11906-019-0909-zDOI Listing
January 2019
1 Read

Innate and Innate-Like Immune System in Hypertension and Vascular Injury.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada.

Purpose Of Review: To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury.

Recent Findings: Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Read More

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http://dx.doi.org/10.1007/s11906-019-0907-1DOI Listing
January 2019
1 Read

Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose Of Review: Previous trials definitively established that lowering systolic blood pressure (BP) to 140 mmHg prevented heart failure (HF) exacerbations, but the potential benefits and risks of further BP reduction remain unclear due to a paucity of trial-based data.

Recent Findings: A recent secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) found that in older, high-risk, non-diabetic participants with systolic hypertension, a BP treatment target < 120 mmHg resulted in a 36% lower rate of acute decompensated HF as compared with a BP target < 140 mmHg. Those participants with incident HF had a 26-fold increased risk of subsequent cardiovascular events and death. Read More

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http://link.springer.com/10.1007/s11906-019-0913-3
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http://dx.doi.org/10.1007/s11906-019-0913-3DOI Listing
January 2019
4 Reads

A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback.

Curr Hypertens Rep 2019 Jan 18;21(1). Epub 2019 Jan 18.

Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202-2689, USA.

Purpose Of Review: In this review, we summarized the current knowledge of connecting tubule-glomerular feedback (CTGF), a novel mechanism of renal microcirculation regulation that integrates sodium handling in the connecting tubule (CNT) with kidney hemodynamics.

Recent Findings: Connecting tubule-glomerular feedback is a crosstalk communication between the CNT and the afferent arteriole (Af-Art), initiated by sodium chloride through the epithelial sodium channel (ENaC). High sodium in the CNT induces Af-Art vasodilation, increasing glomerular pressure and the glomerular filtration rate and favoring sodium excretion. Read More

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http://dx.doi.org/10.1007/s11906-019-0911-5DOI Listing
January 2019
2 Reads

Recent Advances in Imaging of Hypertensive Heart Disease.

Curr Hypertens Rep 2019 Jan 14;21(1). Epub 2019 Jan 14.

Department of Cardiology, University of Virginia, Charlottesville, VA, USA.

Purpose Of Review: To review recent advances in the imaging of hypertensive heart disease (HHD) with an emphasis on developments in the imaging of diffuse myocardial fibrosis using cardiac magnetic resonance (CMR).

Recent Findings: HHD results from long-standing hypertension and is characterized by the development of left ventricular hypertrophy and diffuse interstitial fibrosis. Diffuse fibrosis traditionally required endomyocardial biopsy to diagnose, but recent developments using T1 mapping in CMR allow for noninvasive assessment. Read More

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http://dx.doi.org/10.1007/s11906-019-0910-6DOI Listing
January 2019
2 Reads

Impact of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia.

Curr Hypertens Rep 2019 Jan 10;21(1). Epub 2019 Jan 10.

Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, 078-8510, Japan.

Purpose Of Review: To estimate the impact of the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for high blood pressure (BP) on the next hypertension guidelines in Asia.

Recent Findings: The 2017 ACC/AHA guidelines for high BP in adults changed the diagnostic threshold and the management goal of BP from 140/90 to 130/80 mmHg. Another characteristic of the new guideline is its focus on a practical approach for the effective management of hypertension by using home and ambulatory BP monitoring; this point is also recommended in the 2014 Japanese Society of Hypertension Guidelines for the Management of Hypertension. Read More

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http://dx.doi.org/10.1007/s11906-019-0906-2DOI Listing
January 2019
1 Read

Correction to: Chronotherapy for Hypertension.

Curr Hypertens Rep 2018 Dec 4;21(1). Epub 2018 Dec 4.

Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Rd. L606, Portland, OR, 97239, USA.

The meta-analysis referenced in the "Obstructive Sleep Apnea" section should instead refer to a meta-analysis for chronic kidney disease. Additionally, there are two mis-numbered reference citations in the "chronic kidney disease" section (ref. 107 should ref. Read More

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http://link.springer.com/10.1007/s11906-018-0905-8
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http://dx.doi.org/10.1007/s11906-018-0905-8DOI Listing
December 2018
2 Reads

The Mediterranean Diet: Lost in Translation.

Curr Hypertens Rep 2018 Nov 14;20(12):104. Epub 2018 Nov 14.

UCF College of Medicine, HCA GME Consortium Gainesville, Orlando, FL, USA.

Purpose Of Review: Despite substantive evidence documenting the efficacy of the Mediterranean diet to reduce cardiovascular events, underutilization is common. An overview of the data set supporting the role of the Mediterranean diet as confirmed in both observational and interventional trials should stimulate greater clinician interest in the diet. Additionally, the availability of patient-friendly tools that enable prompt and easy adoption of the Mediterranean diet, that are able to be used by clinicians who claim no special expertise in diet knowledge, should simplify the path to successful dietary change. Read More

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http://dx.doi.org/10.1007/s11906-018-0904-9DOI Listing
November 2018
1 Read

Inflammation in Salt-Sensitive Hypertension and Renal Damage.

Curr Hypertens Rep 2018 Oct 30;20(12):103. Epub 2018 Oct 30.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, 27710, USA.

Purpose Of Review: Low-grade inflammation drives elevations in blood pressure (BP) and consequent target organ damage in diverse experimental models of hypertension. Here, we discuss recent advances elucidating immune-mediated mechanisms of BP elevation and associated target organ damage.

Recent Findings: Inflammatory mediators produced by immune cells or target organs act on the kidney, vasculature, skin, and nervous system to modulate hypertension. Read More

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http://link.springer.com/10.1007/s11906-018-0903-x
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http://dx.doi.org/10.1007/s11906-018-0903-xDOI Listing
October 2018
21 Reads

Out of Office Blood Pressure Measurement in Pregnancy and the Postpartum Period.

Curr Hypertens Rep 2018 Oct 25;20(12):101. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology and Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: Hypertensive disorders of pregnancy are increasing in prevalence and associated with significant maternal and perinatal morbidity and mortality.

Recent Findings: Increased emphasis has been placed recently on the use of out-of-office (i.e. Read More

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http://link.springer.com/10.1007/s11906-018-0901-z
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http://dx.doi.org/10.1007/s11906-018-0901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327956PMC
October 2018
5 Reads

The Relationship Between Psychosocial Status and Hypertensive Condition.

Curr Hypertens Rep 2018 Oct 25;20(12):102. Epub 2018 Oct 25.

Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Purpose Of Review: The aim of the paper is to test the influence of social status and psychological well-being (independent variables) on hypertensive condition (dependent variable), when adjusting for traditional risk factors of cardiovascular disease (control variables). The analysis is based on data collected from SEPHAR III, a nationally representative epidemiologic study of the Romanian adult population.

Recent Findings: Understanding the social roots of health issues is of considerable importance in developing effective strategies and policies. Read More

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http://link.springer.com/10.1007/s11906-018-0902-y
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http://dx.doi.org/10.1007/s11906-018-0902-yDOI Listing
October 2018
11 Reads

Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure.

Curr Hypertens Rep 2018 Oct 5;20(12):100. Epub 2018 Oct 5.

Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue, SL39, New Orleans, LA, 70112-2699, USA.

Purpose Of Review: Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of RAS components by pro-inflammatory factors.

Recent Findings: Angiotensin II (Ang II), which is produced by RAS, induces vasoconstriction and consequent blood pressure elevation. Read More

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http://dx.doi.org/10.1007/s11906-018-0900-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203444PMC
October 2018
1 Read

Obesity and Pulmonary Hypertension.

Curr Hypertens Rep 2018 Oct 5;20(12):99. Epub 2018 Oct 5.

Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Purpose Of Review: Whether the present obesity epidemic will increase the prevalence of pulmonary hypertension over the next decades is unclear. We review the obesity-related mechanisms that may further the development and progression of pulmonary hypertension.

Recent Findings: Systemic and local inflammation, insulin resistance and oxidative stress contribute to the pathobiology of obesity and pulmonary arterial hypertension. Read More

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http://link.springer.com/10.1007/s11906-018-0899-2
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http://dx.doi.org/10.1007/s11906-018-0899-2DOI Listing
October 2018
4 Reads

Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials.

Curr Hypertens Rep 2018 Oct 3;20(11):98. Epub 2018 Oct 3.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose Of Review: Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressure.

Recent Finding: Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Read More

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https://www.researchgate.net/publication/327580357_Effect_of
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http://link.springer.com/10.1007/s11906-018-0898-3
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http://dx.doi.org/10.1007/s11906-018-0898-3DOI Listing
October 2018
4 Reads
3.440 Impact Factor

Chronotherapy for Hypertension.

Curr Hypertens Rep 2018 Sep 28;20(11):97. Epub 2018 Sep 28.

Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Rd. L606, Portland, OR, 97239, USA.

Purpose Of Review: Given the emerging knowledge that circadian rhythmicity exists in every cell and all organ systems, there is increasing interest in the possible benefits of chronotherapy for many diseases. There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events. Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk. Read More

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http://link.springer.com/10.1007/s11906-018-0897-4
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http://dx.doi.org/10.1007/s11906-018-0897-4DOI Listing
September 2018
18 Reads

Adipose Tissue and Modulation of Hypertension.

Curr Hypertens Rep 2018 Sep 18;20(11):96. Epub 2018 Sep 18.

Translational Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 0A4, Canada.

Purpose Of Review: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN. Read More

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http://dx.doi.org/10.1007/s11906-018-0894-7DOI Listing
September 2018
5 Reads
3.440 Impact Factor

SPRINT and the Kidney: What Have We Learned?

Curr Hypertens Rep 2018 Sep 14;20(11):95. Epub 2018 Sep 14.

Department of Medicine, University Hospitals Cleveland Medical Center, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH, 44106, USA.

Purpose Of Review: To review the impact of the Systolic Blood Pressure Interventional Trial (SPRINT) on renal function and chronic kidney disease.

Recent Findings: Hypertension is a risk factor for cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). The benefits of intensive blood pressure lowering in the CKD population in previous studies are unclear. Read More

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http://dx.doi.org/10.1007/s11906-018-0895-6DOI Listing
September 2018
15 Reads

Skin Sodium and Hypertension: a Paradigm Shift?

Curr Hypertens Rep 2018 Sep 13;20(11):94. Epub 2018 Sep 13.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Box 98, Addenbrookes Hospital, Cambridge, CB2 0QQ, UK.

Purpose Of Review: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role.

Recent Findings: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Read More

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http://dx.doi.org/10.1007/s11906-018-0892-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153561PMC
September 2018
1 Read

Catheter-Based Renal Denervation for Hypertension.

Curr Hypertens Rep 2018 Sep 10;20(11):93. Epub 2018 Sep 10.

The Ohio State, Columbus, OH, USA.

Purpose Of Review: This review was undertaken to update readers on the field of therapeutic renal denervation for hypertension during the 2016 through 2018 period.

Recent Findings: After the failure of Symplicity HTN-3 to meet its top line objective, intense scrutiny revealed several possible concerns addressed by the newer investigations into the area of renal denervation. These included better device technology, more intense subject monitoring for off-protocol antihypertensive drug usage, and deeper penetration into the renal vasculature by the interventionist. Read More

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http://dx.doi.org/10.1007/s11906-018-0896-5DOI Listing
September 2018
13 Reads

Modulation of Sympathetic Overactivity to Treat Resistant Hypertension.

Curr Hypertens Rep 2018 Sep 7;20(11):92. Epub 2018 Sep 7.

Department of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, NC, 27599, USA.

Purpose Of Review: To review the role and evidence for sympathetic overactivity in resistant hypertension and review the therapies that have been studied to modulate the sympathetic nervous system to treat resistant hypertension, with a focus on non-pharmacologic therapies such as renal denervation, baroreflex activation therapy, and carotid body ablation.

Recent Findings: Based on the two best current techniques available for assessing sympathetic nerve activity, resistant hypertension is characterized by increased sympathetic nerve activity. Several device therapies, including renal denervation baroreflex activation therapy and carotid body ablation, have been developed as non-pharmacologic means of reducing blood pressure in resistant hypertension. Read More

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http://dx.doi.org/10.1007/s11906-018-0893-8DOI Listing
September 2018
2 Reads

Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review.

Curr Hypertens Rep 2018 Aug 29;20(10):91. Epub 2018 Aug 29.

Optics and Imaging Centre, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.

Purpose Of Review: Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development.

Recent Findings: It is apparent that different genes show significance in varying populations. Read More

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http://link.springer.com/10.1007/s11906-018-0891-x
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http://dx.doi.org/10.1007/s11906-018-0891-xDOI Listing
August 2018
17 Reads

Novel Medical Treatments for Hypertension and Related Comorbidities.

Curr Hypertens Rep 2018 Aug 25;20(10):90. Epub 2018 Aug 25.

UAB Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, ZRB 1034, 703 19th St S, Birmingham, AL, 35233, USA.

Purpose Of Review: The purpose of this review is to summarize the most recent data available on advances in development of novel medical treatments for hypertension and related comorbidities.

Recent Findings: Approximately half of all hypertensive patients have not achieved goal blood pressure with current available antihypertensive medications. Recent landmark studies and new hypertension guidelines have called for stricter blood pressure control, creating a need for better strategies for lowering blood pressure. Read More

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http://dx.doi.org/10.1007/s11906-018-0890-yDOI Listing
August 2018
1 Read

Enhancing Mitochondrial Health to Treat Hypertension.

Curr Hypertens Rep 2018 Aug 17;20(10):89. Epub 2018 Aug 17.

Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose Of Review: This review summarizes literature pertaining to the dawning field of therapeutic targeting of mitochondria in hypertension and discusses the potential of these interventions to ameliorate hypertension-induced organ damage.

Recent Findings: In recent years, mitochondrial dysfunction has been reported as an important contributor to the pathogenesis of hypertension-related renal, cardiac, and vascular disease. This in turn prompted development of novel mitochondria-targeted compounds, some of which have shown promising efficacy in experimental studies and safety in clinical trials. Read More

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http://dx.doi.org/10.1007/s11906-018-0889-4DOI Listing
August 2018
1 Read
3.440 Impact Factor

Mineralocorticoids and Cardiovascular Disease in Females with Insulin Resistance and Obesity.

Curr Hypertens Rep 2018 Aug 14;20(10):88. Epub 2018 Aug 14.

Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, MO, USA.

Purpose Of The Review: In the present review, we will discuss the evidence and the mechanisms underlying the complex interplay between obesity, mineralocorticoid receptor activation, and cardiovascular dysfunction with special emphasis on the pathogenesis of cardiovascular disease (CVD) in obese and insulin-resistant females.

Recent Findings: Since the initial isolation of aldosterone in 1953 and the cloning of the mineralocorticoid receptor (MR) decades later, our understanding has expanded tremendously regarding their involvement in the pathogenesis of CVD. Recent results from both pre-clinical and clinical studies support a close correlation between increase adiposity and enhanced aldosterone production (MR activation). Read More

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http://dx.doi.org/10.1007/s11906-018-0887-6DOI Listing
August 2018
11 Reads

Environmental Toxicant Exposure and Hypertensive Disorders of Pregnancy: Recent Findings.

Curr Hypertens Rep 2018 Aug 8;20(10):87. Epub 2018 Aug 8.

Department of Pediatrics, New York University School of Medicine, New York, NY, USA.

Purpose Of Review: To assess the strength of evidence for associations between environmental toxicants and hypertensive disorders of pregnancy, suggest potential biological mechanisms based on animal and in vitro studies, and highlight avenues for future research.

Recent Findings: Evidence is strongest for links between persistent chemicals, including lead, cadmium, organochlorine pesticides, and polycyclic biphenyls, and preeclampsia, although associations are sometimes not detectable at low-exposure levels. Results have been inconclusive for bisphenols, phthalates, and organophosphates. Read More

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http://dx.doi.org/10.1007/s11906-018-0888-5DOI Listing
August 2018
3 Reads

Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review.

Curr Hypertens Rep 2018 Aug 7;20(10):86. Epub 2018 Aug 7.

Global Health Research Center, Duke Kunshan University, No.8 Duke Avenue, Kunshan, Jiangsu, China.

Purpose Of Review: This study aims to systematically review existing evidence on the effectiveness of mobile health technology (mHealth) interventions in addressing medication adherence among people with hypertension.

Recent Findings: Twenty-one studies of mHealth interventions were included in the final review after systematic searching and screening of publications from 2000 to 2017 in PubMed, Web of Science, and Embase. Key features of the mHealth interventions include high intervention intensity, multifactorial components, and patient-centered approaches with tailored content and interaction. Read More

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http://dx.doi.org/10.1007/s11906-018-0886-7DOI Listing
August 2018
2 Reads

The Role of Out-of-Clinic Blood Pressure Measurements in Preventing Hypertension.

Curr Hypertens Rep 2018 Jul 30;20(10):85. Epub 2018 Jul 30.

Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin 2nd Road 197, Shanghai, 200025, China.

Purpose Of Review: One of the possible strategies for preventing hypertension is identifying high-risk people and then implementing lifestyle modifications or therapeutic interventions. Out-of-clinic blood pressure measurements, either home or ambulatory blood pressure monitoring, may identify people with early blood pressure elevation or white-coat or masked hypertension and potentially help prevent hypertension. In this review, we will summarize the evidence on the role of out-of-clinic blood pressure measurements in preventing hypertension either from prehypertension or high normal or elevated blood pressure, or from white-coat or masked hypertension. Read More

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http://dx.doi.org/10.1007/s11906-018-0884-9DOI Listing
July 2018
3 Reads
3.440 Impact Factor

The Incidence and Pathophysiology of the Obesity Paradox: Should Peritoneal Dialysis and Kidney Transplant Be Offered to Patients with Obesity and End-Stage Renal Disease?

Curr Hypertens Rep 2018 Jul 26;20(10):84. Epub 2018 Jul 26.

School of Medicine, Department of Medicine, Section of Nephrology and Hypertension, Louisiana State University Health Sciences Center-New Orleans, LSUHSC: 1542 Tulane Ave, New Orleans, LA, 70112, USA.

Purpose Of Review: To educate nephrologists and primary-care physicians about the incidence, pathophysiology, and survival benefits of the obesity paradox in end-stage renal disease (ESRD). This review also discusses the future of kidney transplant and peritoneal dialysis in obese dialysis patients.

Recent Findings: Obesity paradox in ESRD was first reported three decades ago, and since then, there have been several epidemiological studies that confirmed the phenomenon. Read More

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http://dx.doi.org/10.1007/s11906-018-0882-yDOI Listing
July 2018
3 Reads

Phosphodiesterase Inhibition in the Treatment of Preeclampsia: What Is New?

Curr Hypertens Rep 2018 Jul 26;20(10):83. Epub 2018 Jul 26.

Department of Internal Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Purpose Of Review: The present study intends to review the possibility of using phosphodiesterase inhibitors as a treatment option for preeclampsia, addressing potential risks and benefits.

Recent Findings: Preeclampsia is the most common hypertensive disorder of pregnancy, often responsible for severe maternal and fetal complications, which can lead to early pregnancy termination and death. Despite the numerous studies, its pathophysiology is still unclear, although it seems to involve a multiplicity of complex factors related to angiogenesis, ineffective vasodilation, oxidative stress, inflammatory cytokines, and endothelial dysfunction. Read More

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http://dx.doi.org/10.1007/s11906-018-0883-xDOI Listing
July 2018
2 Reads

Big Data and Blood Pressure Control: Insights from the PAMELA and BP-CARE Study Cohorts.

Curr Hypertens Rep 2018 Jul 26;20(10):82. Epub 2018 Jul 26.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Pergolesi 33, 20052, Monza (Milan), Italy.

Purpose Of Review: The paper examines the patterns of BP control achieved in two large scale observational studies, i.e., the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study and the Blood Pressure control rate and CArdiovascular Risk profilE (BP-CARE), carried out in the general population and in treated hypertensive patients, respectively. Read More

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http://dx.doi.org/10.1007/s11906-018-0885-8DOI Listing
July 2018
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The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.

Curr Hypertens Rep 2018 Jul 13;20(9):81. Epub 2018 Jul 13.

School of Health, Sport and Applied Sciences, St Mary's University, London, TW1 4SX, UK.

Purpose Of Review: The aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans.

Recent Findings: There is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed. Read More

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http://dx.doi.org/10.1007/s11906-018-0881-zDOI Listing
July 2018
28 Reads

An Overview of Metabolic Phenotyping in Blood Pressure Research.

Curr Hypertens Rep 2018 Jul 10;20(9):78. Epub 2018 Jul 10.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Purpose Of The Review: This review presents the analytical techniques, processing and analytical steps used in metabolomics phenotyping studies, as well as the main results from epidemiological studies on the associations between metabolites and high blood pressure.

Recent Findings: A variety of metabolomic approaches have been applied to a range of epidemiological studies to uncover the pathophysiology of high blood pressure. Several pathways have been suggested in relation to blood pressure including the possible role of the gut microflora, inflammatory, oxidative stress, and lipid pathways. Read More

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http://dx.doi.org/10.1007/s11906-018-0877-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061189PMC
July 2018
5 Reads

Orexins, Sleep, and Blood Pressure.

Curr Hypertens Rep 2018 Jul 10;20(9):79. Epub 2018 Jul 10.

Department of Neurology, University of Helsinki, Helsinki, Finland.

Purpose Of Review: The aim of this review was to summarize collected data on the role of orexin and orexin neurons in the control of sleep and blood pressure.

Recent Findings: Although orexins (hypocretins) have been known for only 20 years, an impressive amount of data is now available regarding their physiological role. Hypothalamic orexin neurons are responsible for the control of food intake and energy expenditure, motivation, circadian rhythm of sleep and wake, memory, cognitive functions, and the cardiovascular system. Read More

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http://dx.doi.org/10.1007/s11906-018-0879-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061179PMC
July 2018
21 Reads

Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk.

Curr Hypertens Rep 2018 Jul 10;20(9):77. Epub 2018 Jul 10.

Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA.

Purpose Of The Review: Low-grade systemic inflammation increases residual cardiovascular risk. The pathogenesis of low-grade systemic inflammation is not well understood.

Recent Findings: Visceral adipose tissue accumulates when the subcutaneous adipose tissue can no longer store excess nutrients. Read More

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http://dx.doi.org/10.1007/s11906-018-0880-0DOI Listing
July 2018
17 Reads

The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?

Curr Hypertens Rep 2018 Jul 10;20(9):80. Epub 2018 Jul 10.

Optics and Imaging Centre, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

Purpose Of Review: Because of the significant discrepancies on this topic, this review will focus on the role of uric acid in PE, uric acid as a predictor of preeclampsia and fetal growth retardation. We considered eligible review and original articles relevant to the research question.

Recent Findings: Hypertensive disorders of pregnancy such as preeclampsia (PE) are a major cause of both maternal and fetal morbidity and mortality worldwide. Read More

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http://dx.doi.org/10.1007/s11906-018-0878-7DOI Listing
July 2018
26 Reads

Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening.

Curr Hypertens Rep 2018 Jul 6;20(9):76. Epub 2018 Jul 6.

Diabetes and Cardiovascular Research Center, University of Missouri School of Medicine, D109 Diabetes Center HSC, One Hospital Drive, Columbia, MO, 65212, USA.

Purpose Of Review: Increased arterial stiffness, an abnormal structural and functional change in the vascular wall, is a precursor for hypertension, coronary heart disease, stroke, and associated cardiovascular disease (CVD). The aim of this paper is to review the etiology of arterial stiffening and potential therapeutic approaches to modulate arterial fibrosis and stiffness.

Recent Findings: The Framingham Heart Study demonstrated that arterial stiffness is an independent predictor of CVD and related morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s11906-018-0876-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319394PMC
July 2018
4 Reads

Sympathetic Nervous System, Sleep, and Hypertension.

Curr Hypertens Rep 2018 Jul 6;20(9):74. Epub 2018 Jul 6.

Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Milano, Italy.

Purpose Of Review: To evaluate the relation between sleep alterations, with or without breathing disorders, and incidence of hypertension and other cardiovascular diseases RECENT FINDINGS: Several studies have clearly shown the mechanisms linking sleep disorders and cardiovascular diseases. The sympathetic hyperactivity seems to play a fundamental role in favoring and sustaining the increase in blood pressure values. Several other mechanisms also contribute to this effect and to the increase cardiovascular risk. Read More

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http://dx.doi.org/10.1007/s11906-018-0874-yDOI Listing
July 2018
1 Read

Evaluation and Management of Stage 2 Hypertension in Pediatric Patients.

Curr Hypertens Rep 2018 Jul 6;20(9):73. Epub 2018 Jul 6.

Department of Pediatrics, Division of Pediatric Nephrology, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.

Purpose Of Review: To update the definition and clinical practice of stage 2 hypertension (HTN) in pediatrics.

Recent Findings: The 2017 American Academy of Pediatrics Clinical Practice Guideline (AAP CPG) for Screening and Management of High Blood Pressure in Children and Adolescent includes new normative blood pressure tables for children and adolescents ages 1 to 17 years and new definitions for stage 2 HTN. This review will highlight these aspects as well as new recommendations in the guideline specific to stage 2 HTN. Read More

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http://dx.doi.org/10.1007/s11906-018-0873-zDOI Listing
July 2018
2 Reads

Future Direction for Using Artificial Intelligence to Predict and Manage Hypertension.

Curr Hypertens Rep 2018 Jul 6;20(9):75. Epub 2018 Jul 6.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland, OH, USA.

Purpose Of Review: Evidence that artificial intelligence (AI) is useful for predicting risk factors for hypertension and its management is emerging. However, we are far from harnessing the innovative AI tools to predict these risk factors for hypertension and applying them to personalized management. This review summarizes recent advances in the computer science and medical field, illustrating the innovative AI approach for potential prediction of early stages of hypertension. Read More

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http://dx.doi.org/10.1007/s11906-018-0875-xDOI Listing
July 2018
2 Reads
3.440 Impact Factor