603 results match your criteria Current Heart Failure Reports[Journal]


Diuretic Resistance in Heart Failure.

Curr Heart Fail Rep 2019 Feb 14. Epub 2019 Feb 14.

Department of Emergency Medicine, Vanderbilt University Medical Center, 1313 21st Ave. S, 703 Oxford House, Nashville, TN, 37232, USA.

Purpose Of Review: Diuretic resistance (DR) occurs along a spectrum of relative severity and contributes to worsening of acute heart failure (AHF) during an inpatient stay. This review gives an overview of mechanisms of DR with a focus on loop diuretics and summarizes the current literature regarding the prognostic value of diuretic efficiency and predictors of natriuretic response in AHF.

Recent Findings: The pharmacokinetics of diuretics are impaired in chronic heart failure, but little is known about mechanisms of DR in AHF. Read More

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http://dx.doi.org/10.1007/s11897-019-0424-1DOI Listing
February 2019

Cardiac Contractility Modulation and Baroreflex Activation Therapy in Heart Failure Patients.

Curr Heart Fail Rep 2019 Feb 14. Epub 2019 Feb 14.

Division of Cardiovascular Medicine, Wexner Medical Center at The Ohio State University, 473 W. 12th Avenue Suite 200, Columbus, OH, 43210, USA.

Purpose Of Review: Despite advances in medical therapy, heart failure with reduced ejection fraction (HFrEF) is still a leading cause of mortality, hospitalizations, and healthcare costs. In this review, we describe two novel, implantable devices for the treatment of patients with HFrEF, cardiac contractility modulation (CCM), and baroreflex activation therapy (BAT), and summarize literature regarding these devices from the last 5 years.

Recent Findings: CCM improves quality of life and functional capacity as assessed by the Minnesota Living with Heart Failure Questionnaire (MLHFQ) score, 6-min hall walk test (6MHWT) distance, New York Heart Association (NYHA) functional class, peak oxygen consumption (pVO), heart failure (HF) hospitalizations, and mortality. Read More

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http://dx.doi.org/10.1007/s11897-019-0422-3DOI Listing
February 2019

The Role of Troponin for Acute Heart Failure.

Curr Heart Fail Rep 2019 Feb 14. Epub 2019 Feb 14.

Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.

Purpose Of Review: To review the mechanisms, clinical interpretation, prognostic role, and future research regarding cardiac troponin (cTn) in the assessment of acute heart failure (AHF) patients presenting to the emergency department (ED).

Recent Findings: cTn has become a necessary component of the evaluation of AHF patients in the ED, largely because of its independently predictive value as a prognosticator of poor outcome. High-sensitivity assays (hs-cTn) may add risk stratification value beyond conventional assays, specifically with regard to identifying low-risk AHF patients. Read More

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http://dx.doi.org/10.1007/s11897-019-0420-5DOI Listing
February 2019

Vasodilator Therapies in the Treatment of Acute Heart Failure.

Curr Heart Fail Rep 2019 Feb 14. Epub 2019 Feb 14.

Department of Emergency Medicine, Indiana University, 720 Eskenazi Ave., Fifth Third Bank Building 3rd Floor, Indianapolis, IN, 46202, USA.

Purpose Of Review: Vasodilators are commonly recommended to treat acute heart failure (AHF), yet they are infrequently used. This review aims to evaluate the clinical utility of traditional, historical, and novel vasodilators in the treatment of AHF.

Recent Findings: No traditional vasodilator (i. Read More

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http://dx.doi.org/10.1007/s11897-019-0421-4DOI Listing
February 2019

Implementation of Heart Transplantation Program to Advanced Heart Failure Patients in Brazil.

Curr Heart Fail Rep 2019 Feb 2. Epub 2019 Feb 2.

Heart Transplantation Department, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil.

Purpose: Heart transplantation is the gold standard treatment for advanced heart failure. Left ventricular assist devices (LVADs), despite being a good option for these patients, are not quite available in developing countries. Time spent in heart transplant waiting list has increased lately even in regions where the number of transplants has also risen showing that a new strategy should be sought. Read More

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http://dx.doi.org/10.1007/s11897-019-0418-zDOI Listing
February 2019
1 Read

Quality Measures in Heart Failure: the Past, the Present, and the Future.

Curr Heart Fail Rep 2019 Feb 2. Epub 2019 Feb 2.

National Institute of Science and Technology for Health Technology Assessment (IATS), CNPq, 2350 Ramiro Barcelos, room 21507, Porto Alegre, RS, 90035-903, Brazil.

Purpose Of Review: This paper reviews performance measure in health, their importance, and methodologic issues, focusing on metrics for health failure patients. Quality measures are instruments to assess structural aspects or processes of care aiming to guarantee that optimal patient outcomes are achieved. As heart failure is a chronic condition in which established therapies reduce mortality and hospital admissions, there are quite a lot of initiatives that aim to monitor for quality of care and to coordinate the disease management. Read More

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http://dx.doi.org/10.1007/s11897-019-0417-0DOI Listing
February 2019

Hyperkalaemia in Heart Failure-Pathophysiology, Implications and Therapeutic Perspectives.

Curr Heart Fail Rep 2018 Dec;15(6):390-397

Department for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Medical Center, Kirrberger Strasse, 66421, Homburg, Saarland, Germany.

Purpose Of Review: Hyperkalaemia is a frequent and sometimes life-threatening condition that may be associated with arrhythmia and cardiac dysfunction. Evaluating the prevalence of hyperkalaemia in patients with heart failure (HF) and potential treatments of this condition is essential for patients using renin-angiotensin-aldosterone system inhibitors or angiotensin receptor-neprilysin inhibitor and mineralocorticoid receptor antagonists, which represent the cornerstone and highly proven life-saving therapy.

Recent Findings: Novel findings from the past few years include data regarding the epidemiology, pathomechanisms, implications and novel therapeutic approaches to counteract hyperkalaemia in patients with HF. Read More

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http://link.springer.com/10.1007/s11897-018-0413-9
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http://dx.doi.org/10.1007/s11897-018-0413-9DOI Listing
December 2018
11 Reads

Who Benefits From a Defibrillator-Balancing the Risk of Sudden Versus Non-sudden Death.

Curr Heart Fail Rep 2018 Dec;15(6):376-389

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland.

Purpose Of Review: Treatment with a defibrillator can reduce the risk of sudden death by terminating ventricular arrhythmias. The identification of patient groups in whom this function reduces overall mortality is challenging. In this review, we summarise the evidence for who benefits from a defibrillator. Read More

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http://link.springer.com/10.1007/s11897-018-0416-6
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http://dx.doi.org/10.1007/s11897-018-0416-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267371PMC
December 2018
5 Reads

Depression, Anxiety, and Cognitive Impairment : Comorbid Mental Health Disorders in Heart Failure.

Curr Heart Fail Rep 2018 Dec;15(6):398-410

Department of Internal Medicine I and Comprehensive Heart Failure Center, University and University Hospital of Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany.

Purpose Of Review: Depression, anxiety, and cognitive impairment constitute established risk markers for incident cardiovascular disease (CVD) and are associated with impaired life expectancy and quality of life and high hospitalization rates and healthcare expenditure. This review summarizes current knowledge about mental health disorders in patients with CVD and heart failure (HF).

Recent Findings: Emerging evidence suggests various shared pathophysiological mechanisms between psychological comorbidities and CVD (e. Read More

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http://link.springer.com/10.1007/s11897-018-0414-8
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http://dx.doi.org/10.1007/s11897-018-0414-8DOI Listing
December 2018
15 Reads

Role of the Wearable Defibrillator in Newly Diagnosed Heart Failure.

Curr Heart Fail Rep 2018 Dec;15(6):368-375

Rhythmology and Electrophysiology, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose Of Review: The wearable defibrillator (WCD) was shown to be safe and effective in detecting and terminating ventricular tachyarrhythmias and therefore allows temporary protection from sudden cardiac death. This review gives an overview of the current data on WCD in newly diagnosed cardiomyopathy.

Recent Findings: Patients with newly diagnosed heart failure and reduced LVEF appear to have an increased risk of ventricular tachyarrhythmias, which may decrease over time when heart failure medication is optimized and left ventricular function improves. Read More

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http://dx.doi.org/10.1007/s11897-018-0415-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267372PMC
December 2018
3 Reads

Setting Up a Heart Failure Program in 2018: Moving Towards New Paradigm(s).

Curr Heart Fail Rep 2018 Dec;15(6):357-367

Department of Medicine, Montreal Heart Institute, Université de Montréal, 5000, Belanger East, Montreal, Quebec, H1T1C8, Canada.

Purpose Of Review: Heart failure (HF) is the first cause of hospitalization in the elderly in Western countries, generating tremendous healthcare costs. Despite the spread of multidisciplinary post-discharge programs, readmission rates have remained unchanged over time. We review the recent developments in this setting. Read More

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http://dx.doi.org/10.1007/s11897-018-0412-xDOI Listing
December 2018
73 Reads

Improving Provider Adherence to Guideline Recommendations in Heart Failure.

Curr Heart Fail Rep 2018 Dec;15(6):350-356

John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, Brisbane, Australia.

Purpose Of Review: Heart failure clinical practice guidelines are fundamental and serve as framework for providers to deliver evidence-based care that correlates with enhanced patient outcomes. However, adherence, particularly to guideline-directed medical therapy, remains suboptimal for a multitude of reasons.

Recent Findings: Despite robust clinical trials, updated guidelines and an expert consensus statement from American Heart Association, American College of Cardiology, and Heart Failure Society of America registry data signal that heart failure patients do not receive appropriate pharmacotherapy and may receive an intracardiac device without prior initiation or optimization of medical therapy. Read More

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http://dx.doi.org/10.1007/s11897-018-0411-yDOI Listing
December 2018
1 Read

Gene Therapy for Heart Failure: New Perspectives.

Curr Heart Fail Rep 2018 Dec;15(6):340-349

Institute of Life Sciences, Fondazione Toscana Gabriele Monasterio, Scuola Superiore Sant'Anna, Piazza Martiri della Liberta` 33, 56127, Pisa, Italy.

Purpose Of Review: The current knowledge of pathophysiological and molecular mechanisms responsible for the genesis and development of heart failure (HF) is absolutely vast. Nonetheless, the hiatus between experimental findings and therapeutic options remains too deep, while the available pharmacological treatments are mostly seasoned and display limited efficacy. The necessity to identify new, non-pharmacological strategies to target molecular alterations led investigators, already many years ago, to propose gene therapy for HF. Read More

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http://link.springer.com/10.1007/s11897-018-0410-z
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http://dx.doi.org/10.1007/s11897-018-0410-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250586PMC
December 2018
10 Reads

Impaired Exercise Tolerance in Heart Failure: Role of Skeletal Muscle Morphology and Function.

Curr Heart Fail Rep 2018 Dec;15(6):323-331

Department of Medicine, Section of Geriatric Cardiology, Veterans Affairs Geriatric Research Education, and Clinical Center, University of Pittsburgh, 3471 Fifth Avenue, Suite 500, Pittsburgh, PA, 15213, USA.

Purpose Of Review: To discuss the impact of deleterious changes in skeletal muscle morphology and function on exercise intolerance in patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as the utility of exercise training and the potential of novel treatment strategies to preserve or improve skeletal muscle morphology and function.

Recent Findings: Both HFrEF and HFpEF patients exhibit a reduction in percent of type I (oxidative) muscle fibers and oxidative enzymes coupled with abnormal mitochondrial respiration. These skeletal muscle abnormalities contribute to impaired oxidative metabolism with an earlier shift towards glycolytic metabolism during exercise that is strongly associated with exercise intolerance. Read More

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http://dx.doi.org/10.1007/s11897-018-0408-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250583PMC
December 2018
10 Reads

Diastolic Stress Testing Along the Heart Failure Continuum.

Curr Heart Fail Rep 2018 Dec;15(6):332-339

The University of Texas at Arlington, Engineering Research Building 453, 500 UTA Blvd, Arlington, TX, 76019, USA.

Purpose Of Review: This review summarizes recent developments highlighting the clinical utility of diastolic stress testing along the heart failure continuum.

Recent Findings: Invasive hemodynamic assessment of cardiac filling pressures during physiological stress is the gold-standard technique for unmasking diastolic dysfunction. Non-invasive surrogate techniques, such as Doppler ultrasound, have shown excellent agreement with invasive approaches and are now recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Read More

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http://dx.doi.org/10.1007/s11897-018-0409-5DOI Listing
December 2018
2 Reads

Cardiorenal Interactions Revisited: How to Improve Heart Failure Outcomes in Patients With Chronic Kidney Disease.

Curr Heart Fail Rep 2018 Oct;15(5):307-314

INSERM UMR-S 942, Paris, France.

Purpose Of The Review: To summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD).

Recent Findings: Diagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration. Read More

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http://dx.doi.org/10.1007/s11897-018-0406-8DOI Listing
October 2018
1 Read

Non-response to Cardiac Resynchronization Therapy.

Curr Heart Fail Rep 2018 Oct;15(5):315-321

Heart Research Follow-Up Program, Cardiology Division, University of Rochester Medical Center, 265 Crittenden Blvd., Box 653, Rochester, NY, 14642, USA.

Purpose Of Review: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality.

Recent Findings: Despite its effectiveness, the "non-response" rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers. Read More

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http://dx.doi.org/10.1007/s11897-018-0407-7DOI Listing
October 2018
3 Reads

Clinical Implications of Serum Biomarkers of Cardiac Stress in Aortic Stenosis.

Curr Heart Fail Rep 2018 Oct;15(5):281-286

Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9047, USA.

Purpose Of Review: The purpose of this review is to outline the relationship between serum biomarkers of cardiac stress and the pathophysiologic progression of aortic stenosis, to identify studies exploring the utility of biomarkers in the risk stratification and management of patients with aortic stenosis, and to highlight the biomarkers most practical to management of patients with aortic stenosis.

Recent Findings: Several biomarkers have been identified that reflect various aspects of the pathogenesis of calcific aortic stenosis, subsequent hemodynamic obstruction leading to myocardial remodeling, oxidative stress and injury, and concomitant systemic inflammation. These markers are associated with adverse outcomes in aortic stenosis and offer incremental value in risk prediction over traditional clinical assessment for aortic stenosis. Read More

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http://dx.doi.org/10.1007/s11897-018-0403-yDOI Listing
October 2018
2 Reads

Heart Failure and Stroke.

Curr Heart Fail Rep 2018 Oct;15(5):287-296

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

Purpose: Ischemic stroke significantly contributes to morbidity and mortality in heart failure (HF). The risk of stroke increases significantly, with coexisting atrial fibrillation (AF). An aggravating factor could be asymptomatic paroxysms of AF (so-called silent AF), and therefore, the risk stratification in these patients remains difficult. Read More

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http://link.springer.com/10.1007/s11897-018-0405-9
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http://dx.doi.org/10.1007/s11897-018-0405-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132785PMC
October 2018
5 Reads

Peripartum Cardiomyopathy: an Update.

Curr Heart Fail Rep 2018 Oct;15(5):297-306

Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, 4th floor Chris Barnard Building, Cape Town, South Africa.

Purpose Of Review: Peripartum cardiomyopathy (PPCM) is an idiopathic disorder defined as heart failure occurring in women during the last month of pregnancy and up to 5 months postpartum. In this review, we outline recent reports about the disease pathogenesis and management and highlight the use of diagnosis and prognosis biomarkers.

Recent Findings: Novel data strengthen the implication of endothelial function in PPCM pathogenesis. Read More

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http://dx.doi.org/10.1007/s11897-018-0404-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132730PMC
October 2018
4 Reads

Decompensated Heart Failure and Renal Failure: What Is the Current Evidence?

Curr Heart Fail Rep 2018 Aug;15(4):224-238

Department of Cardiology and Pneumology, University of Göttingen Medical Centre, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.

Purpose Of Review: Acute decompensated heart failure (ADHF) is one of the biggest challenges in the management of chronic heart failure. Despite several advances in medical and device therapy, high readmission and mortality rates continue to be a burden on healthcare systems worldwide. The aim of the current review is to provide an overview on current as well as future approaches in cardiorenal interactions in patients with ADHF. Read More

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http://link.springer.com/10.1007/s11897-018-0397-5
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http://dx.doi.org/10.1007/s11897-018-0397-5DOI Listing
August 2018
19 Reads

The Confounding Effects of Non-cardiac Pathologies on the Interpretation of Cardiac Biomarkers.

Curr Heart Fail Rep 2018 Aug;15(4):239-249

Division of Cardiovascular Medicine, University of California, San Diego, 9434 Medical Center Drive, La Jolla, CA, 92037, USA.

Purpose Of Review: Cardiac biomarkers play important roles in routine evaluation of cardiac patients. But while these biomarkers can be extremely valuable, none of them should ever be used by themselves-without adding the clinical context. This paper explores the non-cardiac pathologies that can be seen with the cardiac biomarkers most commonly used. Read More

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http://dx.doi.org/10.1007/s11897-018-0398-4DOI Listing
August 2018
2 Reads

The Effect of Left Ventricular Assist Device Therapy on Cardiac Biomarkers: Implications for the Identification of Myocardial Recovery.

Curr Heart Fail Rep 2018 Aug;15(4):250-259

Department of Medicine, Division of Cardiology, University of Chicago, Chicago, IL, USA.

Purpose Of Review: Left ventricular assist device (LVAD) therapy serves as mainstay therapy for bridge to transplantation and destination therapy. Evidence is now mounting on the role of LVAD therapy as bridge to recovery. In the current review, we will summarize the data on biomarkers of myocardial recovery following LVAD implantation. Read More

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http://dx.doi.org/10.1007/s11897-018-0399-3DOI Listing
August 2018
15 Reads

Identifying and Managing Hibernating Myocardium: What's New and What Remains Unknown?

Curr Heart Fail Rep 2018 Aug;15(4):214-223

The Rayne Institute, St Thomas' Hospital, 4th Floor Lambeth Wing, Westminster Bridge Road, London, SE1 7EH, UK.

Purpose Of Review: Hibernation is an important and reversible cause of myocardial dysfunction in ischaemic heart failure.

Recent Findings: Hibernation is an adaptive process that promotes myocyte survival over maintaining contractile function. It is innate to mammalian physiology, sharing features with physiological hibernation in other species. Read More

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http://dx.doi.org/10.1007/s11897-018-0396-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061160PMC
August 2018
1 Read

Pharmacologic Management of Cancer Therapeutics-Induced Cardiomyopathy in Adult Cancer Survivors.

Curr Heart Fail Rep 2018 Aug;15(4):270-279

Clinical Effectiveness, Wolters Kluwer Health, 1100 Terex Road, Hudson, OH, 44236, USA.

Purpose Of Review: The number of cancer survivors is exponentially increasing worldwide, due to both advances in cancer detection and treatment strategies, as well as the aging and growth of the population. This decrease in cancer mortality has brought forth a concurrent increase of non-ischemic (toxic) dilated cardiomyopathy in the survivor population, also known as cancer therapeutics-induced cardiomyopathy (CTIC). The optimal pharmacological management for this condition is still elusive, and hence, the focus of this work. Read More

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http://dx.doi.org/10.1007/s11897-018-0401-0DOI Listing
August 2018
7 Reads

Complicated Acute Heart Failure Subsets.

Curr Heart Fail Rep 2018 Aug;15(4):199-200

Department of Cardiology, University Hospitals Coventry & Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.

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http://dx.doi.org/10.1007/s11897-018-0402-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061167PMC
August 2018
5 Reads

Decompensated Heart Failure With Ventricular Arrhythmia: How Useful Is VT Ablation?

Curr Heart Fail Rep 2018 Aug;15(4):201-213

Cardiology Department, University Hospital Birmingham, Birmingham, B18 7QH, UK.

Purpose Of Review: Ventricular arrhythmias are common in patients with heart failure. Their management especially in the context of decompensated heart failure poses a clinical challenge to modern cardiologists. In this review article, we aim to summarise the current evidence on the epidemiology, pathophysiology, and management of ventricular tachycardia in heart failure, focusing primarily on the use of catheter ablation. Read More

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http://dx.doi.org/10.1007/s11897-018-0395-7DOI Listing
August 2018
2 Reads

Prevention of Cardiotoxicities With Traditional and Novel Chemotherapeutic Agents.

Curr Heart Fail Rep 2018 Aug;15(4):260-269

Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart and Vascular Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk J1-5, Cleveland, OH, 44195, USA.

Purpose Of Review: This review will discuss strategies to prevent cardiotoxicity associated with chemotherapeutics. Forty years ago, investigators identified dose-dependent cardiotoxicity related to anthracycline-based regimens. Over recent decades, the development of more selective, mechanism-based chemotherapeutics has been associated with both on-target and off-target adverse cardiovascular sequelae. Read More

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http://dx.doi.org/10.1007/s11897-018-0400-1DOI Listing
August 2018
9 Reads

Correction to: Vitamin D and Heart Failure.

Curr Heart Fail Rep 2018 Aug;15(4):280

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue; Preston Research Building, Suite 383, Nashville, TN, 37232-6300, USA.

The original version of this article, published in Current Heart Failure Reports, Volume 14, Issue 5, October 2017, erroneously cited an author's name as Marshall Brinkley, D" when it should be "Brinkley, DM." Read More

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http://dx.doi.org/10.1007/s11897-018-0394-8DOI Listing
August 2018
1 Read

Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials.

Curr Heart Fail Rep 2018 06;15(3):191-197

Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA.

Purpose Of Review: Several novel therapeutics being tested in patients with heart failure are based on myocardial energetics. This review will provide a summary of the recent trials in this area, including therapeutic options targeting various aspects of cellular and mitochondrial metabolism.

Recent Findings: Agents that improve the energetic balance in myocardial cells have the potential to improve clinical heart failure status. Read More

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http://dx.doi.org/10.1007/s11897-018-0386-8DOI Listing
June 2018
24 Reads

Essential Elements of Early Post Discharge Care of Patients with Heart Failure.

Curr Heart Fail Rep 2018 06;15(3):181-190

Sections of Cardiovascular Medicine, Yale University School of Medicine, 135 College Street, Suite 230, New Haven, CT, 06520, USA.

Purpose Of Review: Heart failure is associated with an enormous burden on both patients and health care systems in the USA. Several national policy initiatives have focused on improving the quality of heart failure care, including reducing readmissions following hospitalization, which are common, costly, and, at least in part, preventable. The transition from inpatient to ambulatory care setting and the immediate post-hospitalization period present an opportunity to further optimize guideline concordant medical therapy, identify reversible issues related to worsening heart failure, and evaluate prognosis. Read More

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http://dx.doi.org/10.1007/s11897-018-0393-9DOI Listing
June 2018
2 Reads

Optimizing Cardiac Resynchronization Therapy: an Update on New Insights and Advancements.

Curr Heart Fail Rep 2018 06;15(3):156-160

Electrophysiology, Cleveland Clinic Heart and Vascular Institute, 9500 Euclid Avenue, J2-2, Cleveland, OH, USA.

Purpose Of Review: This review focuses on the current advancements in optimizing patient response to cardiac resynchronization therapy (CRT).

Recent Findings: It has been well known that not every patient will derive benefit from CRT, and of those that do, there are varying levels of response. Optimizing CRT begins well before device implant and involves appropriate patient selection and an understanding of the underlying substrate. Read More

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http://dx.doi.org/10.1007/s11897-018-0391-yDOI Listing
June 2018
4 Reads

Has the Time Come to Be More Aggressive With Bariatric Surgery in Obese Patients With Chronic Systolic Heart Failure?

Authors:
Amanda R Vest

Curr Heart Fail Rep 2018 06;15(3):171-180

Division of Cardiology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA, 02111, USA.

Purpose Of Review: Obesity is a strong risk factor for the development of heart failure (HF). Diet, exercise, and weight-loss pharmacotherapies have limited potential to achieve significant and sustainable weight loss, especially in patients with symptomatic systolic HF. This review seeks to determine the role of bariatric surgery for patients with systolic HF and obesity. Read More

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http://link.springer.com/10.1007/s11897-018-0390-z
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http://dx.doi.org/10.1007/s11897-018-0390-zDOI Listing
June 2018
20 Reads

Novel Insights and Treatment Strategies for Right Heart Failure.

Curr Heart Fail Rep 2018 06;15(3):141-155

Section of Heart Failure and Cardiac Transplantation, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH, 44195, USA.

Purpose Of Review: The function of the right ventricle (RV) is intimately linked to its preload (systemic volume status) and afterload (pulmonary vasculature). In this review, we explore current knowledge in RV physiology, RV function assessment, causes of right heart failure (RHF), and specific treatment strategies for RHF.

Recent Findings: We examine the evidence behind new pharmacological therapies available, such as macitentan and riociguat in the treatment of specific etiologies of RHF. Read More

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http://dx.doi.org/10.1007/s11897-018-0389-5DOI Listing
June 2018
6 Reads

Nutritional Interventions in Heart Failure: Challenges and Opportunities.

Authors:
Conor P Kerley

Curr Heart Fail Rep 2018 06;15(3):131-140

Chronic Cardiovascular Disease Management Unit and Heart Failure Unit, St Vincent's Healthcare Group/St Michael's Hospital, County Dublin, Ireland.

Purpose Of Review: There is a growing body of evidence that nutritional factors influence the incidence of heart failure (HF). The current manuscript aims to collate evidence relating to nutritional intervention in the treatment of HF as well as to provide context regarding challenges and opportunities in the field.

Recent Findings: Despite the accepted importance of nutritional factors relating to cardiovascular disease severity, there is surprisingly little human intervention research regarding dietary intake and HF. Read More

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http://dx.doi.org/10.1007/s11897-018-0388-6DOI Listing
June 2018
2 Reads

Contraceptive Strategies in Women With Heart Failure or With Cardiac Transplantation.

Curr Heart Fail Rep 2018 06;15(3):161-170

Cleveland Clinic-Fairview Hospital, 18099 Lorain Ave, Ste 245, Cleveland, OH, 44111, USA.

Purpose Of Review: We describe contraception for two groups of women: (1) women with heart failure and (2) women with cardiac transplantation.

Recent Findings: Medical Eligibility Criteria for contraceptive agents address women with peripartum cardiomyopathy and women with valvular heart disease (Curtis et al. MMWR Recomm Rep 65:1-103, 2016). Read More

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http://dx.doi.org/10.1007/s11897-018-0392-xDOI Listing
June 2018
5 Reads

Management of Sleep Disordered Breathing in Patients with Heart Failure.

Curr Heart Fail Rep 2018 06;15(3):123-130

School of Medicine, University of Maryland, Baltimore, MD, USA.

Purpose Of Review: This paper reviews treatment options for sleep disordered breathing (SDB) in patients with heart failure. We sought to identify therapies for SDB with the best evidence for long-term use in patients with heart failure and to minimize uncertainties in clinical practice by examining frequently discussed questions: what is the role of continuous positive airway pressure (CPAP) in patients with heart failure? Is adaptive servo-ventilation (ASV) safe in patients with heart failure? To what extent is SDB a modifiable risk factor?

Recent Findings: Consistent evidence has demonstrated that the development of SDB in patients with heart failure is a poor prognostic indicator and a risk factor for cardiovascular mortality. However, despite numerous available interventions for obstructive sleep apnea and central sleep apnea, it remains unclear what effect these therapies have on patients with heart failure. Read More

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http://dx.doi.org/10.1007/s11897-018-0387-7DOI Listing
June 2018
3 Reads

Biomarkers of Cardiac Stress and Injury in Athletes: What Do They Mean?

Curr Heart Fail Rep 2018 04;15(2):116-122

Department of Cardiovascular Medicine, Cleveland Clinic, Desk J1-5, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Purpose Of The Review: Markers of myocardial stress, including troponin, creatine kinase, and brain natriuretic peptide are frequently elevated after endurance athletic pursuits. Here, we summarize the current literature pertaining to the potential mechanism of cardiac enzyme release in athletes and seek to determine the clinical implications of these findings.

Recent Findings: Recent studies have highlighted the potential adverse cardiac effects of long-term extreme endurance exercise. Read More

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http://dx.doi.org/10.1007/s11897-018-0385-9DOI Listing
April 2018
2 Reads

The Evolving Role of Cardiorespiratory Fitness and Exercise in Prevention and Management of Heart Failure.

Curr Heart Fail Rep 2018 04;15(2):75-80

Department of Cardiovascular Diseases, John Ochsner Heart & Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.

Purpose Of Review: This paper highlights the dynamic relationship between cardiorespiratory fitness (CRF) and heart failure (HF). As heart failure with preserved ejection fraction (HFpEF) surpasses heart failure with reduced ejection fraction (HFrEF) in prevalence, our void in understanding how to treat this syndrome becomes less justifiable. As such, significant attention has been given to the role that obesity and physical inactivity play, as both risk factors for heart failure, and therapeutic targets for its treatment. Read More

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http://dx.doi.org/10.1007/s11897-018-0382-zDOI Listing
April 2018
15 Reads

Fill in the Gaps of Secondary Mitral Regurgitation: a Continuum Challenge From Pathophysiology to Prognosis.

Curr Heart Fail Rep 2018 04;15(2):106-115

Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy.

Purpose Of Review: Mitral regurgitation (MR) is one of the most frequent valvular heart diseases encountered in clinical practice. In contrast to primary MR, less is still known about the pathophysiology, diagnosis, and prognosis of secondary MR. The purpose of this report is to provide a review, upon the last knowledge reported in the literature, on the role and management of secondary MR in clinical practice. Read More

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http://dx.doi.org/10.1007/s11897-018-0379-7DOI Listing
April 2018
7 Reads

Multiple Avenues of Modulating the Nitric Oxide Pathway in Heart Failure Clinical Trials.

Curr Heart Fail Rep 2018 04;15(2):44-52

Department of Medicine, University of Mississippi, 2500 N. State Street, Jackson, MS, 39216, USA.

Purpose Of Review: This review discusses the integral role of the nitric oxide (NO) pathway in the pathophysiology of heart failure (HF). We emphasize potential therapeutic targets in the NO pathway and review contemporary clinical trials evaluating these novel therapeutic options.

Recent Findings: Nitrates, neprilysin inhibitors, and phosphodiesterase (PDE) inhibitors have all proven to be efficacious in HF patients with systolic dysfunction, with the former two classes of medications producing a net mortality benefit. Read More

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http://dx.doi.org/10.1007/s11897-018-0383-yDOI Listing
April 2018
5 Reads

The Future of Biomarker-Guided Therapy for Heart Failure After the Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) Study.

Curr Heart Fail Rep 2018 04;15(2):37-43

Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, GRB-800, Boston, MA, 02114, USA.

Purpose Of Review: Biomarker-guided management of patients with chronic heart failure with reduced ejection fraction (HFrEF) remains controversial.

Recent Findings: Biomarkers have established roles for diagnosis and prognostication in HF. Pilot data suggested that use of natriuretic peptides might be helpful to guide HF care. Read More

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http://dx.doi.org/10.1007/s11897-018-0381-0DOI Listing
April 2018
10 Reads

Right Ventricular Dysfunction and Its Contribution to Morbidity and Mortality in Left Ventricular Heart Failure.

Curr Heart Fail Rep 2018 04;15(2):94-105

Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA, USA.

Purpose: In patients with left-sided HF, there has been less emphasis on the pathophysiology of the RV in terms of diagnostic evaluation and treatment, versus focus on structural abnormalities of the LV. This review seeks to delineate the importance of RV dysfunction in terms of its contribution to symptomatic limitations and cardiovascular outcomes in patients with left-sided HF.

Recent Findings: Recent studies have demonstrated that RV dysfunction is common in both HFpEF and HFrEF, but more pronounced in HFrEF. Read More

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http://dx.doi.org/10.1007/s11897-018-0378-8DOI Listing
April 2018
5 Reads

Updates on Device-Based Therapies for Patients with Heart Failure.

Curr Heart Fail Rep 2018 04;15(2):53-60

Division of Cardiovascular Medicine, Department of Internal Medicine, Augusta University, 95 Collier Rd Suite 3000, Atlanta, GA, 30309, USA.

Purpose Of Review: Heart failure is a growing epidemic. Optimal medical therapy remains the cornerstone of heart failure management but device-based therapies have been shown to contribute to morbidity and mortality reduction.

Recent Findings: Multiple investigational trials had been conducted in the past decade that helped us better understand and manage heart failure. Read More

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http://dx.doi.org/10.1007/s11897-018-0384-xDOI Listing
April 2018
2 Reads

Chronic Right Ventricular Pacing in the Heart Failure Population.

Curr Heart Fail Rep 2018 04;15(2):61-69

King's College London, London, UK.

Purpose Of Review: We review the trials that have demonstrated potentially harmful effects from right ventricular (RV) apical pacing as well as reviewing the evidence of alternative RV pacing sites and cardiac resynchronization therapy (CRT) for patients who have heart failure and atrioventricular (AV) block.

Recent Findings: The role of CRT in patients with AV block and impaired left ventricular function remains an important consideration. The BLOCK HF trial demonstrated better outcomes with CRT pacing over RV pacing in patients with left ventricular systolic dysfunction (LVSD) and AV block who were expected to have a high RV pacing burden, but failed to demonstrate a mortality benefit. Read More

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http://dx.doi.org/10.1007/s11897-018-0376-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857555PMC
April 2018
3 Reads

The Psychosocial Treadmill: the Road to Improving High-risk Behavior in Advanced Therapy Candidates.

Authors:
Laura Newman

Curr Heart Fail Rep 2018 04;15(2):70-74

The Ohio State University Wexner Medical Center, 452 West 10th Avenue Suite 7216, Columbus, OH, 43210, USA.

Purpose Of Review: The purpose of this review is to explore the evaluation and identification of psychosocial risk factors during the heart transplant evaluation process with the goal of improving psychosocial candidacy prior to transplant listing. Subsequently, more patients will be able to receive life-saving heart transplant and experience success after transplant.

Recent Findings: Evaluating and identifying psychosocial risk factors is an essential component of the transplant evaluation process. Read More

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http://dx.doi.org/10.1007/s11897-018-0380-1DOI Listing
April 2018
2 Reads

Pulmonary Vascular Disease: Hemodynamic Assessment and Treatment Selection-Focus on Group II Pulmonary Hypertension.

Curr Heart Fail Rep 2018 04;15(2):81-93

Division of Cardiology, Department of Medicine, Medical University of South Carolina (MUSC), Strom Thurmond Gazes Building, Room 215, 114 Doughty St/MSC592, Charleston, SC, 29425, USA.

Purpose Of Review: Pulmonary hypertension due to left heart disease (PH-LHD) is the most common cause of pulmonary hypertension worldwide, yet therapies used to treat pulmonary arterial hypertension have failed to show efficacy in this population. Proper hemodynamic assessment and differentiation of pulmonary hypertension phenotypes is therefore critical for both current clinical practice and future research and therapeutic efforts.

Recent Findings: Substantial recent efforts have sought to improve the hemodynamic characterization of pulmonary hypertension for both diagnostic and prognostic purposes. Read More

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http://dx.doi.org/10.1007/s11897-018-0377-9DOI Listing
April 2018
2 Reads

An Appraisal of Biomarker-Based Risk-Scoring Models in Chronic Heart Failure: Which One Is Best?

Curr Heart Fail Rep 2018 02;15(1):24-36

Heart Failure and Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: While prediction models incorporating biomarkers are used in heart failure, these have shown wide-ranging discrimination and calibration. This review will discuss externally validated biomarker-based risk models in chronic heart failure patients assessing their quality and relevance to clinical practice.

Recent Findings: Biomarkers may help in determining prognosis in chronic heart failure patients as they reflect early pathologic processes, even before symptoms or worsening disease. Read More

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http://dx.doi.org/10.1007/s11897-018-0375-yDOI Listing
February 2018
5 Reads

The Emerging Role of Cardiac Magnetic Resonance Imaging in the Evaluation of Patients with HFpEF.

Curr Heart Fail Rep 2018 02;15(1):1-9

Department of Cardiology, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Purpose Of Review: To give an update on the emerging role of cardiac magnetic resonance imaging in the evaluation of patients with heart failure with preserved ejection fraction (HFpEF). This is important as the diagnosis of HFpEF remains challenging and cardiac imaging is pivotal in establishing the function of the heart and whether there is evidence of structural heart disease or diastolic dysfunction. Echocardiography is widely available, although the gold standard in quantifying heart function is cardiac magnetic resonance (CMR) imaging. Read More

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http://dx.doi.org/10.1007/s11897-018-0372-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811579PMC
February 2018
5 Reads

Frailty Assessment in Heart Failure: an Overview of the Multi-domain Approach.

Curr Heart Fail Rep 2018 02;15(1):17-23

Western Sydney Nursing & Midwifery Research Centre, Blacktown Clinical & Research School, Blacktown Hospital, Western Sydney University & Western Sydney Local Health District, Marcel Crescent, Blacktown, NSW, 2148, Australia.

Purpose Of Review: The study aims (1) to provide a contemporary description of frailty assessment in heart failure and (2) to provide an overview of multi-domain frailty assessment in heart failure.

Recent Findings: Frailty assessment is an important predictive measure for mortality and hospitalisation in individuals with heart failure. To date, there are no frailty assessment instruments validated for use in heart failure. Read More

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http://link.springer.com/10.1007/s11897-018-0373-0
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http://dx.doi.org/10.1007/s11897-018-0373-0DOI Listing
February 2018
10 Reads