962 results match your criteria Current HIV Research[Journal]


The pattern of non-AIDS-defining cancers in the HIV population: epidemiology, risk factors and prognosis. A review.

Curr HIV Res 2019 Mar 27. Epub 2019 Mar 27.

Infectious Diseases Unit, A. Manzoni Hospital, Lecco. Italy.

The advent of highly active antiretroviral therapy (HAART) has significantly reduced the incidence of AIDS events, including AIDS-defining malignancies. Nevertheless, several cohort studies conducted in the post-HAART period have reported an increasing risk of non-AIDS-defining cancers (NADC). Overall, the potential mechanisms leading to an increased risk of developing NADCs probably involve multiple known and unknown factors. Read More

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http://dx.doi.org/10.2174/1570162X17666190327153038DOI Listing
March 2019
2 Reads

Community HIV Screening among MSM in Three Indonesian Cities.

Curr HIV Res 2019 Mar 20. Epub 2019 Mar 20.

AIDS Research Center, Atma Jaya Catholic University, Jakarta. Indonesia.

Background: Indonesia lags its peers with regard to ART coverage of PLHIV. Insufficient HIV testing among MSM and other key affected populations remains a barrier to increasing ART coverage.

Objective: This report presents the results of the first government-endorsed implementation research study of a community screening approach to increasing the rate of HIV testing among MSM in three cities. Read More

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http://dx.doi.org/10.2174/1570162X17666190321115419DOI Listing
March 2019
2.135 Impact Factor

Mechanisms of Blood Retinal Barrier Disruption by HIV-1.

Curr HIV Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Ophthalmology, Huashan Hospital of Fudan University, Shangha. China.

It has been found that human immunodeficiency virus (HIV)-1 RNA or antigens can be detected in the intraocular tissues of HIV-1 patients even under effective highly active anti-retroviral therapy (HAART). In vivo, blood retinal barrier (BRB) establishes a critical, physiological guardian against microbial invasion of the eye, but may be compromised in the presence of HIV-1. Envelope glycoprotein gp120 is exposed on the surface of the HIV envelope, essential for virus entry into cells by attachment to specific cell surface receptors. Read More

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http://dx.doi.org/10.2174/1570162X17666190315163514DOI Listing
March 2019
3 Reads

Contribution of the Microbiota to Intestinal Homeostasis and its Role in the Pathogenesis of HIV-1 Infection.

Curr HIV Res 2019 Mar 10. Epub 2019 Mar 10.

Grupo Inmunovirología, Facultad de Medicina. Universidad de Antioquia, Medellín. Colombia.

During HIV infection, massive destruction of CD4+ T cells ensues, preferentially depleting the Th17 subset at the gut-associated lymphoid tissue (GALT), leading to the loss of mucosal integrity and an increase in cell permeability. This process favors microbial translocation between the intestinal lumen and the circulatory system, contributing to the persistent immune activation and chronic inflammation characteristic of HIV infection. Thus, the gut microbiota plays an integral role in maintaining the structure and function of the mucosal barrier, a critical factor for immune homeostasis. Read More

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http://dx.doi.org/10.2174/1570162X17666190311114808DOI Listing
March 2019
1 Read

Prediction of CD4+ Cells Counts in HIV/AIDS Patients based on Sets and Probability Theories.

Curr HIV Res 2018 ;16(6):416-424

Special Internship and Focusing Area "Physical and Mathematical Theories Applied to Medicine", Medicine Faculty, Nueva Granada Military University, Bogota, Colombia.

Background: Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes.

Objective: To improve the methodology probabilities prediction in 5000-9000 leukocytes ranges.

Method: from sets A, B, C and D defined in a previous study, and based on CD4+ prediction established on the total number of leukocytes and lymphocytes, induction was performed using data from 10 patients with HIV, redefining the sets A and C that describe the lymphocytes behavior relative to leukocytes. Read More

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http://dx.doi.org/10.2174/1570162X17666190306125819DOI Listing
January 2018
4 Reads

Induction of a robust humoral response using HIV-1 VLPMPER-V3as a novel candidate vaccine in BALB/c mice.

Curr HIV Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Hepatitis, AIDS and Blood borne diseases, Pasteur Institute of Iran, Tehran. Iran.

Background: Several approaches have not been successful to suppress HIV (Human immunodeficiency virus) infection among infected individuals or to prevent it yet. In order to expand strong HIV specific humoral and cellular responses, Virus-like particles (VLPs) as potential vaccines show significant increase in neutralizing antibodies secretion, T-cell count and also secretion of cytokines.

Objective: This study aimed at immunological evaluation of VLPs harboring high copy of MPER-V3 in BALB/c mice. Read More

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http://dx.doi.org/10.2174/1570162X17666190306124218DOI Listing
March 2019
10 Reads
2.135 Impact Factor

Assessment of Antibody Interference of Enfuvirtide (T20) Function Shows Assay Dependent Variability.

Curr HIV Res 2018 ;16(6):404-415

Department of Pediatrics, School of Medicine and Biomedical Sciences, University at Buffalo, NY, United States.

Background: During HIV infection, fusion of the viral and cellular membranes is dependent on folding of the gp41 trimer into a six-helix bundle. Fusion inhibitors, such as the antiretroviral Enfuvirtide (T20), interfere with the formation of the gp41 six-helix bundle. Recent in vitro studies reveal that the gp41 immunodominant region one targeting antibody 3D6 can block T20 interference, but the clinical and pathophysiologic significance of this finding is unclear. Read More

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http://dx.doi.org/10.2174/1570162X17666190228154850DOI Listing
January 2018
1 Read

The Per-1 Short Isoform Inhibits de novo HIV-1 Transcription in Resting CD4+ T-cells.

Curr HIV Res 2018 ;16(6):384-395

Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, Shenyang, China.

Background: Understanding of the restriction of HIV-1 transcription in resting CD4+ Tcells is critical to find a cure for AIDS. Although many negative factors causing HIV-1 transcription blockage in resting CD4+ T-cells have been found, there are still unknown mechanisms to explore.

Objective: To explore the mechanism for the suppression of de novo HIV-1 transcription in resting CD4+ T-cells. Read More

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http://www.eurekaselect.com/170059/article
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http://dx.doi.org/10.2174/1570162X17666190218145048DOI Listing
January 2018
13 Reads
2.135 Impact Factor

Antiretroviral Therapy-associated Adverse Drug Reactions and their Effects on Virologic Failure- A Retrospective Cohort Study in Nigeria.

Curr HIV Res 2018 ;16(6):436-446

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.

Background: Adverse drug reactions (ADRs) associated with antiretroviral therapy (ART) can rapidly reverse the gains of ART resulting in poor health outcomes. We need an improved understanding of specific ART-related ADRs that influence virologic outcomes.

Objective: To investigate the frequency of clinical ADRs and assess their effect on virologic failure in patients on ART. Read More

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http://dx.doi.org/10.2174/1389450120666190214144609DOI Listing
January 2018
2 Reads

Potential Role of Regulatory T Cells in Mother-to-Child Transmission of HIV.

Authors:
Peter A Kessler

Curr HIV Res 2018 ;16(6):396-403

Department of Pediatrics, Emory University School of Medicine, Atlanta GA, United States.

Background: Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the fetus as well as in mother-to-child transmission of HIV is under-studied. Read More

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http://dx.doi.org/10.2174/1570162X17666190213094624DOI Listing
January 2018
9 Reads

Real World Patient-reported Outcomes in HIV-infected Adults Switching to EVIPLERA®, Because of a Previous Intolerance to cART. PRO-STR Study.

Curr HIV Res 2018 ;16(6):425-435

Pharmacoeconomics & Outcomes Research Iberia, Madrid, Spain.

Background: To investigate the impact of switching from stable Combined Antiretroviral Therapy (cART) to single-tablet regimen (RPV/FTC/TDF=EVIPLERA® /COMPLERA®) on patient- reported outcomes in HIV-infected adults who cannot tolerate previous cART, in a real-world setting.

Methods: PRO-STR is a 48-week observational, prospective, multicenter study. Presence and magnitude of symptoms (main endpoint), health-related quality-of-life (HRQoL), adherence, satisfaction with treatment and patient preferences were assessed. Read More

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http://dx.doi.org/10.2174/1570162X17666190212163518DOI Listing
January 2018

Molecular Antiretroviral Resistance Markers of Human Immunodeficiency Virus-1 of CRF01_AE Subtype in Bali, Indonesia.

Curr HIV Res 2018 ;16(5):374-382

Animal Biomedical and Molecular Biology Laboratory, Faculty of Veterinary Medicine, Udayana University, Jl. Sesetan-Markisa 6, Denpasar 80226, Bali, Indonesia.

Background: Molecular epidemiological study of human immunodeficiency virus drugresistant (HIVDR) markers is challenging in areas where the dominant subtype is non-B.

Objective: Here we provide molecular data for HIVDR in the CRF01_AE subtype in Bali, Indonesia.

Method: Seventy patients were enrolled in this study and grouped into treatment failure and treatment naïve groups. Read More

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http://dx.doi.org/10.2174/1570162X17666190204101154DOI Listing
January 2018

Tobacco and Antiretrovirals Modulate Transporter, Metabolic Enzyme, and Antioxidant Enzyme Expression and Function in Polarized Macrophages.

Curr HIV Res 2018 ;16(5):354-363

Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center College of Pharmacy, Memphis, United States.

Background: Cigarette smoking increases systemic oxidative stress, inflammation, and viral replication in individuals with HIV. Macrophages are infected during HIV infection and serve as an important reservoir throughout the process. Macrophages exist in two phenotypes, the classically activated M1 macrophage and alternatively activated M2 macrophage. Read More

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http://dx.doi.org/10.2174/1570162X17666190130114531DOI Listing
January 2018
1 Read

The Spontaneous Control of HIV Replication is Characterized by Decreased Pathological Changes in the Gut-associated Lymphoid Tissue.

Curr HIV Res 2018 ;16(5):338-344

Grupo Inmunovirologia, Facultad de Medicina, Universidad de Antioquia UdeA, Medellin, Colombia.

Background: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immune responses that correlate with viral control; however, the histopathological characterization of GALT in those patients is still missing. In this study, we evaluated pathological alterations in GALT, trying to associate them with clinical parameters of HIV infected patients with or without evidence of viral control. Read More

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http://dx.doi.org/10.2174/1570162X17666190130115113DOI Listing
January 2018

Near Full-length Genomic Sequencing and Molecular Analysis of HIV-Infected Individuals in a Network-based Intervention (TRIP) in Athens, Greece: Evidence that Transmissions Occur More Frequently from those with High HIV-RNA.

Curr HIV Res 2018 ;16(5):345-353

Medical School, University of Cyprus, Nicosia, Cyprus.

Background: TRIP (Transmission Reduction Intervention Project) was a network-based, contact tracing approach to locate and link to care, mostly people who inject drugs (PWID) with recent HIV infection.

Objective: We investigated whether sequences from HIV-infected participants with high viral load cluster together more frequently than what is expected by chance.

Methods: Paired end reads were generated for 104 samples using Illumina MiSeq next-generation sequencing. Read More

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http://dx.doi.org/10.2174/1570162X17666190130120757DOI Listing
January 2018
2.135 Impact Factor

Dynamic Characteristics and HIV Infection of Men who have Sex with Men from 2011 to 2017 in Yinchuan, Ningxia, China.

Curr HIV Res 2018 ;16(5):364-373

Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Objectives: Ningxia Hui Autonomous Region, an important area for ethnic Hui settlement in Northwest China, is a low HIV prevalence region. However, HIV infection rates among men who have sex with men (MSM) in Ningxia have increased to an alarming level, despite scale-up of control measures in recent years. This study aimed to understand the demographical and sexual behavior dynamics of MSM and to explore the factors associated with HIV infection. Read More

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http://dx.doi.org/10.2174/1570162X17666190119094035DOI Listing
January 2018
7 Reads

In Silico Design and Immunologic Evaluation of HIV-1 p24-Nef Fusion Protein to Approach a Therapeutic Vaccine Candidate.

Curr HIV Res 2018 ;16(5):322-337

Hepatitis, AIDS and Bloodborne Diseases Department, Pasteur Institute of Iran, Tehran, Iran.

Background: Acquired immune deficiency syndrome (HIV/AIDS) has been a major global health concern for over 38 years. No safe and effective preventive or therapeutic vaccine has been developed although many products have been investigated. Computational methods have facilitated vaccine developments in recent decades. Read More

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http://dx.doi.org/10.2174/1570162X17666190102151717DOI Listing
January 2018
3 Reads
2.135 Impact Factor

HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.

Curr HIV Res 2018 ;16(4):302-314

Y. R. Gaitonde Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai, India.

Background: Anti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations.

Objective: This study evaluates cytokine expression and T-cells activation in relation to disease non-progression in LTNP. Read More

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http://www.eurekaselect.com/168301/article
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http://dx.doi.org/10.2174/1570162X17666181212122607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416489PMC
January 2018
5 Reads

The Effect of MSM and CD4+ Count on the Development of Cancer AIDS (AIDS-defining Cancer) and Non-cancer AIDS in the HAART Era.

Curr HIV Res 2018 ;16(4):288-296

Community Health and Epidemiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Background: The HIV epidemic is increasing among Men who have Sex with Men (MSM) and the risk for AIDS defining cancer (ADC) is higher among them.

Objective: To examine the effect of MSM and CD4+ count on time to cancer AIDS (ADC) and noncancer AIDS in competing risks setting in the HAART era.

Method: Using Ontario HIV Treatment Network Cohort Study data, HIV-positive adults diagnosed between January 1997 and October 2012 having baseline CD4+ counts ≤ 500 cells/mm3 were evaluated. Read More

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http://dx.doi.org/10.2174/1570162X17666181205130532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416461PMC
January 2018
23 Reads

M918: A Novel Cell Penetrating Peptide for Effective Delivery of HIV-1 Nef and Hsp20-Nef Proteins into Eukaryotic Cell Lines.

Curr HIV Res 2018 ;16(4):280-287

Pilot Nano-Biotechnology Department, Pasteur Institute of Iran, Tehran, Iran.

Background: HIV-1 Nef protein is a possible attractive target in the development of therapeutic HIV vaccines including protein-based vaccines. The most important disadvantage of protein-based vaccines is their low immunogenicity which can be improved by heat shock proteins (Hsps) as an immunomodulator, and cell-penetrating peptides (CPPs) as a carrier.

Methods: In this study, the HIV-1 Nef and Hsp20-Nef proteins were generated in E. Read More

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http://www.eurekaselect.com/168113/article
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http://dx.doi.org/10.2174/1570162X17666181206111859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416460PMC
January 2018
6 Reads
2.135 Impact Factor

Prevalence of HIV in Patients with Malignancy and of Malignancy in HIV Patients in a Tertiary Care Center from North India.

Curr HIV Res 2018 ;16(4):315-320

Department of Medicine, UCLA CARE Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.

Background And Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India.

Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Read More

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http://dx.doi.org/10.2174/1570162X16666181018161616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416457PMC
January 2018
1 Read
2.130 Impact Factor

Correlation of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide- like 3G Genetic Variant rs8177832 with HIV-1 Predisposition in Pakistani Population.

Curr HIV Res 2018 ;16(4):297-301

Department of Medical Laboratory Sciences, Imperial College of Business Studies, Lahore, Pakistan.

Background: Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide- like 3G (APOBEC3G). Read More

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http://dx.doi.org/10.2174/1570162X16666181018155827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416456PMC
January 2018
2 Reads
2.135 Impact Factor

HIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity.

Curr HIV Res 2018 ;16(4):258-269

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, United States.

The implementation of combination antiretroviral therapy (cART) as the primary means of treatment for HIV infection has achieved a dramatic decline in deaths attributed to AIDS and the reduced incidence of severe forms of HIV-associated neurocognitive disorders (HAND) in infected individuals. Despite these advances, milder forms of HAND persist and prevalence of these forms of neurocognitive impairment are rising with the aging population of HIV infected individuals. HIV enters the CNS early in the pathophysiology establishing persistent infection in resident macrophages and glial cells. Read More

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http://www.eurekaselect.com/165912/article
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http://dx.doi.org/10.2174/1570162X16666181003144740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398609PMC
January 2018
6 Reads

Formulation and in-vivo Evaluation of Novel Topical Gel of Lopinavir for Targeting HIV.

Curr HIV Res 2018 ;16(4):270-279

Department of Pharmaceutics, Mumbai University, Mumbai, India.

Background: Lopinavir is a specific reversible inhibitor of the enzyme HIV protease with mean oral bioavailability of less than 20 % due to extensive hepatic metabolism by cytochrome P450 3A4. The reported half-life of Lopinavir is 5-6 hours and the maximum recommended daily dose is 400 mg/day. All the marketed tablet and capsule formulations of lopinavir are generally combined with Ritonavir, a potent inhibitor of cytochrome P450 3A4, to minimize presystemic metabolism of lopinavir. Read More

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http://dx.doi.org/10.2174/1570162X16666180924101650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416462PMC
January 2018
7 Reads

Assessment of Transmitted HIV-1 Drug Resistance Mutations Using Ultra- Deep Pyrosequencing in a Turkish Cohort.

Curr HIV Res 2018 ;16(3):216-221

Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, Istanbul, Turkey.

Background: Antiretroviral treatment (ART) reduces morbidity and mortality caused by human immunodeficiency virus (HIV) infection; however, the emergence of drug-resistant strains poses an important obstacle to treatment success. Using conventional sequencing methods to determine antiretroviral resistance, mutations present in ≥20% of quasispecies can be identified, but drug-resistant minority variants can lead to virologic failure.

Objective: We aimed to assess transmitted drug resistance mutations (TDRMs) within minority variants using ultra-deep pyrosequencing (UDPS). Read More

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http://dx.doi.org/10.2174/1570162X16666180910130112DOI Listing
January 2018
4 Reads

Host Restriction Factors and Human Immunodeficiency Virus (HIV-1): A Dynamic Interplay Involving All Phases of the Viral Life Cycle.

Curr HIV Res 2018 ;16(3):184-207

Retrovirus Laboratory, Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna, Italy.

Mammalian cells have evolved several mechanisms to prevent or block lentiviral infection and spread. Among the innate immune mechanisms, the signaling cascade triggered by type I interferon (IFN) plays a pivotal role in limiting the burden of HIV-1. In the presence of IFN, human cells upregulate the expression of a number of genes, referred to as IFN-stimulated genes (ISGs), many of them acting as antiviral restriction factors (RFs). Read More

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http://dx.doi.org/10.2174/1570162X16666180817115830DOI Listing
January 2018
1 Read

Structural Barriers to Pre-exposure Prophylaxis Use Among Young Sexual Minority Men: The P18 Cohort Study.

Curr HIV Res 2018 ;16(3):237-249

Center for Health, Identity, Behavior & Prevention Studies, New York University, 715 Broadway, New York, NY 10012, United States.

Background: Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrEP), PrEP use remains low. In addition to exploring individual-level factors for this slow uptake, structural drivers of PrEP use must also be identified in order to maximize the effectiveness of biomedical HIV prevention strategies. Read More

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http://dx.doi.org/10.2174/1570162X16666180730144455DOI Listing
January 2018
2 Reads

PrEP Eligibility and Interest Among Clinic- and Community-Recruited Young Black Women in Atlanta, Georgia, USA.

Curr HIV Res 2018 ;16(3):250-255

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, United States.

Background: Atlanta has been identified as an HIV "hot spot" for Black women and ranks 5th in the US with new infections. Yet little is known about PrEP eligibility or interest among young Black women in Atlanta.

Methods: A convenience sample of 1,261 Black women (ages 14-24 years) were recruited from two settings: community venues and sexual health clinics. Read More

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http://dx.doi.org/10.2174/1570162X16666180731143756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352727PMC
January 2018
6 Reads

Microbial Translocation and Immune Activation in HIV-1 Infected Pregnant Women.

Curr HIV Res 2018 ;16(3):208-215

Departments of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, United States.

Background: Immune Activation (IA) has been previously documented in both pregnant (PG) and non-PG HIV-1 infected (HIV+) women as well as in HIV- uninfected PG women; the latter as a result of the fetal allograft. To determine whether the combined effects of HIV and pregnancy result in increased IA and whether IA is associated with Microbial Translocation (MT), we performed a prospective, longitudinal, controlled study during pregnancy and the postpartum (PP) period.

Methods: HIV+ PG women had biomarkers of IA and MT tested at 12-20 weeks (T1), and 24-36 weeks (T2) of pregnancy and at 6-8 weeks Postpartum (T3). Read More

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http://dx.doi.org/10.2174/1570162X16666180731145011DOI Listing
January 2018
18 Reads

Comparison of Demographic, Epidemiological, Immunological, and Clinical Characteristics of Patients with HIV Mono-infection Versus Patients Co-infected with HCV or/and HBV: A Serbian Cohort Study.

Curr HIV Res 2018 ;16(3):222-230

University of Belgrade Faculty of Medicine, University Hospital for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia.

Objective: The study aimed to correlate the status of hepatitis C (HCV) and hepatitis B virus (HBV) co-infection in patients with human immunodeficiency virus (HIV) infection with clinical and demographic data prior to starting highly active antiretroviral therapy (HAART) and assess the impact of HCV and HBV co-infection on the natural history of HIV infection.

Patients And Methods: The study involved a total of 836 treatment-naive patients with available serological status for HBV and HCV at the point of therapy initiation. Patients were stratified into four groups: HIV mono-infection, HIV/HCV, HIV/HBV, and HIV/HCV/HBV co-infection. Read More

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http://dx.doi.org/10.2174/1570162X16666180717115614DOI Listing
January 2018
18 Reads

Therapeutic Outcomes in AIDS-Associated Kaposi's Sarcoma Patients on Antiretroviral Therapy Treated with Chemotherapy at Two Tertiary Hospitals in Lusaka, Zambia.

Curr HIV Res 2018 ;16(3):231-236

Dermatology and Venereology Section, Adult Hospital of University Teaching Hospitals, Lusaka, Zambia.

The incidence of HIV-associated Kaposi's sarcoma (KS) remains high in Zambia in the antiretroviral therapy era. The most efficacious treatment regimen for KS has yet to be established. In both developed and developing countries, treatment regimens have had limited efficacy. Read More

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http://dx.doi.org/10.2174/1570162X16666180711103610DOI Listing
January 2018
22 Reads
2.135 Impact Factor

Sexual Roles, Risk Sexual Behaviours, and HIV Prevalence among Men who Have Sex with Men Seeking HIV Testing in Changsha, China.

Curr HIV Res 2018 ;16(2):174-181

Xiangya School of Nursing of Central South University, 172 Tong Zi Po Road, Changsha 410013, Hunan, China.

Background: HIV infection is prevalent among men who have sex with men (MSM), and sexual roles may be important factors related to it. This study aims to describe the sexual roles, risky sexual behaviors and HIV prevalence among MSM, and to determine associated factors for HIV prevalence.

Methods: A convenient sampling method was used to recruit participants in a non-government organization in Changsha, China. Read More

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http://dx.doi.org/10.2174/1570162X16666180711101643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182933PMC
April 2019
2 Reads

Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy.

Curr HIV Res 2018 ;16(2):143-150

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, 29425, United States.

Background: The role and mechanism of drug use or abuse in Antiretroviral Therapy (ART)-treated HIV disease are not completely known.

Methods: To investigate the impact of drug use on HIV pathogenesis without confounding by HIV replication and ART adherence, we first analyzed the data from our clinical database in 103 HIV+ subjects with viral-suppressed ART treatment by a multiple regression test.

Results: We found that HIV+ drug users had lower CD4+ T cell counts but higher CD8+ T cell counts compared to HIV+ non-drug users, and both drug use and nadir CD4+ T cell counts was independently associated with CD4+ T cell recovery after controlling for sex and age. Read More

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http://dx.doi.org/10.2174/1570162X16666180703151208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115301PMC
April 2019
9 Reads
2.135 Impact Factor

PCR Amplification Strategies Towards Full-length HIV-1 Genome Sequencing.

Curr HIV Res 2018 ;16(2):98-105

National Microbiology Laboratory at JC Wilt Infectious Diseases Research Center, Public Health Agency of Canada, Winnipeg, Canada.

The advent of next-generation sequencing has enabled greater resolution of viral diversity and improved feasibility of full viral genome sequencing allowing routine HIV-1 full genome sequencing in both research and diagnostic settings. Regardless of the sequencing platform selected, successful PCR amplification of the HIV-1 genome is essential for sequencing template preparation. As such, full HIV-1 genome amplification is a crucial step in dictating the successful and reliable sequencing downstream. Read More

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http://dx.doi.org/10.2174/1570162X16666180626152252DOI Listing
April 2019
1 Read

Serum and Bronchoalveolar Lavage Fluid 25(OH)Vitamin D3 Levels in HIV-1 and Tuberculosis: A Cross-Sectional Study from a Tertiary Care Center in North India.

Curr HIV Res 2018 ;16(2):167-173

Department of Biostatistics, Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

Background: Vitamin D is an immunomodulator, and its deficiency is associated with Tuberculosis (TB) infection. Bronchoalveolar lavage fluid (BALF) is a rich milieu of macrophages that form the first line of defense against invading TB bacilli. As there is an increased prevalence of vitamin D deficiency in TB and human immunodeficiency virus-1 (HIV-1) subjects, we intend exploring the possibility of a localized deficiency of vitamin D metabolites in BALF of these patients. Read More

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http://dx.doi.org/10.2174/1570162X16666180528112924DOI Listing
April 2019
2 Reads

Lopinavir/Ritonavir Treatment Induces Oxidative Stress and Caspaseindependent Apoptosis in Human Glioblastoma U-87 MG Cell Line.

Curr HIV Res 2018 ;16(2):106-112

Institute for Maternal and Child Health "Burlo Garofolo", via dell`Istria 65/1, 34137 Trieste, Italy.

Background: Lopinavir and Ritonavir (LPV/r) treatment is widely used to prevent HIV mother-to-child transmission. Nevertheless, studies related to the impact of these compounds on patients, in particular in the foetus and newborns, are strictly required due to the controversial findings reported in the literature concerning possible neurologic side effects following the administration of these drugs.

Objectives: In our study, we evaluated the impact of LPV/r treatment on the human glioblastoma U- 87 MG cell line. Read More

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http://www.eurekaselect.com/162504/article
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http://dx.doi.org/10.2174/1570162X16666180528100922DOI Listing
April 2019
9 Reads

Coreceptor Tropism and Maraviroc Sensitivity of Clonally Derived Ethiopian HIV-1C Strains Using an in-house Phenotypic Assay and Commonly Used Genotypic Methods.

Curr HIV Res 2018 ;16(2):113-120

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.

Objectives: Genotypic Tropism Testing (GTT) tools are generally developed based on HIV-1 subtype B (HIV-1B) and used for HIV-1C as well but with a large discordance of prediction between different methods. We used an established phenotypic assay for comparison with GTT methods and for the determination of in vitro maraviroc sensitivity of pure R5-tropic and dual-tropic HIV-1C.

Methods: Plasma was obtained from 58 HIV-1C infected Ethiopians. Read More

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http://www.eurekaselect.com/162158/article
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http://dx.doi.org/10.2174/1570162X16666180515124836DOI Listing
April 2019
12 Reads

Appearance of Drug Resistance Mutations Among the Dominant HIV-1 Subtype, CRF01_AE in Maumere, Indonesia.

Curr HIV Res 2018 ;16(2):158-166

Department of International Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan.

Background And Objectives: Human Immunodeficiency Virus (HIV) is still a major health issue in Indonesia. In recent years, the appearance of drug resistance-associated mutations has reduced the effectiveness of Antiretroviral Therapy (ART). We conducted genotypic studies, including the detection of drug resistance-associated mutations (from first-line regimen drugs), on HIV-1 genes derived from infected individuals in Maumere, West Nusa Tenggara. Read More

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http://www.eurekaselect.com/161781/article
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http://dx.doi.org/10.2174/1570162X16666180502114344DOI Listing
April 2019
20 Reads

Editorial: The HIV/SIV Envelope Protein: From Structure To Function To Host Evasion.

Curr HIV Res 2018 ;16(1):3-4

Department of Microbiology and Immunology University of North Carolina at Chapel Hill Chapel Hill, NC, United States.

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http://dx.doi.org/10.2174/1570162X1601180419095704DOI Listing
April 2019
4 Reads

Preface.

Curr HIV Res 2018 ;16(1)

National Institute of Health Building 10, Room 7C103 10 Center Drive Bethesda, MD 20892, United States.

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http://dx.doi.org/10.2174/1570162X1601180419095425DOI Listing
April 2019
4 Reads

Identification of Adjacent NNRTI Binding Pocket in Multi-mutated HIV1- RT Enzyme Model: An in silico Study.

Curr HIV Res 2018 ;16(2):121-129

Medicinal and Process Chemistry Division, CSIR- Central Drug Research Institute Lucknow 226031, India.

Introduction: A possible strategy to combat mutant strains is to have a thorough structural evaluation before and after mutations to identify the diversity in the non-nucleoside inhibitor binding pocket and their effects on enzyme-ligand interactions to generate novel NNRTI's accordingly.

Objective: The primary objective of this study was to find effects of multiple point mutations on NNRTI binding pocket. This study included the contribution of each individual mutation in NNIBP that propose an adjacent binding pocket which can be used to discover novel NNRTI derivatives. Read More

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http://dx.doi.org/10.2174/1570162X16666180412165004DOI Listing
April 2019
4 Reads
2.135 Impact Factor

The Effect of Combination Antiretroviral Therapy Use Among HIV Positive Children on the Hazard of AIDS Using Calendar Year as an Instrumental Variable.

Curr HIV Res 2018 ;16(2):151-157

Pediatrics-Infectious Diseases, Stanford University, Stanford, CA, United States.

Background: Instrumental variable (IV) analyses are a common causal inference technique used in the absence of randomized data. Combination Antiretroviral Therapy (cART) was first introduced in 1996 and calendar periods have been used as a proxy for cART use. However, cART use misclassification can bias IV analyses. Read More

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http://www.eurekaselect.com/161132/article
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http://dx.doi.org/10.2174/1570162X16666180409150826DOI Listing
April 2019
5 Reads

Identification and Characterization of Positively Selected Mutations in Nef of Four HIV-1 Major Subtypes from Los Alamos National Laboratory.

Curr HIV Res 2018 ;16(2):130-142

Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: Human immunodeficiency virus-1 (HIV-1) mutates rapidly to escape host immune pressure. This results in the generation of positively selected mutations (PSM) throughout the viral genome. Escape mutations in Nef, one of the accessory proteins of HIV-1, which plays an important role in viral pathogenicity have previously been identified in several large cohort studies, but the evolution of PSMs overtime in various HIV-1 subtypes remains unknown. Read More

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http://dx.doi.org/10.2174/1570162X16666180330140807DOI Listing
April 2019
7 Reads

Investigating HIV-Human Interaction Networks to Unravel Pathogenic Mechanism for Drug Discovery: A Systems Biology Approach.

Curr HIV Res 2018 ;16(1):77-95

Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

Background: Two big issues in the study of pathogens are determining how pathogens infect hosts and how the host defends itself against infection. Therefore, investigating host-pathogen interactions is important for understanding pathogenicity and host defensive mechanisms and treating infections.

Methods: In this study, we used omics data, including time-course data from high-throughput sequencing, real-time polymerase chain reaction, and human microRNA (miRNA) and protein-protein interaction to construct an interspecies protein-protein and miRNA interaction (PPMI) network of human CD4+ T cells during HIV-1 infection through system modeling and identification. Read More

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http://dx.doi.org/10.2174/1570162X16666180219155324DOI Listing
April 2019
3 Reads

IL-10 Promoter -592 Polymorphism may Influence Susceptibility to HIV Infection in South Indian Population.

Curr HIV Res 2018 ;16(1):58-63

Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India.

Background: Genetic factors play an important role in the development of disease susceptibility or protection. Cytokine gene polymorphisms are reported to be associated with altered levels of cytokine production that can impact disease progression in HIV and TB.

Objective: In this study, we studied IL-10 -592(C/A) and TGF-β -509 (C/T) promoter polymorphisms to understand their role in susceptibility or resistance to HIV and TB in a South Indian population. Read More

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http://dx.doi.org/10.2174/1570162X16666180219153752DOI Listing
April 2019
3 Reads

Comparative Genetic Variability in HIV-1 Subtype C vpu Gene in Early Age Groups of Infants.

Curr HIV Res 2018 ;16(1):64-76

Molecular Virology Laboratory, Department of Biotechnology, Jamia Millia Islamia, Central University, New Delhi - 110025, India.

Objective: Identifying the genetic variability in vertically transmitted viruses in early infancy is important to understand the disease progression. Being important in HIV-1 disease pathogenesis, vpu gene, isolated from young infants was investigated to understand the viral characteristics.

Method: Blood samples were obtained from 80 HIV-1 positive infants, categorized in two age groups; acute (<6 months) and early (>6-18 months). Read More

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http://www.eurekaselect.com/159931/article
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http://dx.doi.org/10.2174/1570162X16666180219154601DOI Listing
April 2019
6 Reads

Editorial: Challenges in HIV Epidemiology, Prevention and Treatment.

Curr HIV Res 2017 ;15(6):384-385

Department of Biomedical Sciences Humanitas University Milan, Italy.

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http://dx.doi.org/10.2174/1570162X1505180117092959DOI Listing
April 2019
2 Reads

Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein.

Curr HIV Res 2018 ;16(1):5-12

Department of Medicinal Chemistry and Biological Physics Structure and Design Program, University of Washington, Seattle, WA, United States.

Background: Recent advances in structural characterization of the HIV envelope glycoprotein (Env) have provided a high-resolution glimpse of the architecture of this target for neutralizing antibodies and the machinery responsible for mediating receptor binding and membrane fusion. These structures primarily capture the detailed organization of the receptor-naive, prefusion conformation of Env, but under native solution conditions Env is highly dynamic, sampling multiple conformational states as well as exhibiting local protein flexibility.

Methods: Special emphasis is placed on the use of biophysical methods, including single-molecule fluorescence microscopy and hydrogen/deuterium-exchange mass spectrometry. Read More

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http://www.eurekaselect.com/158536/article
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http://dx.doi.org/10.2174/1570162X16666171222110025DOI Listing
April 2019
5 Reads

Evolution of Host Target Cell Specificity During HIV-1 Infection.

Curr HIV Res 2018 ;16(1):13-20

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Background: Many details of HIV-1 molecular virology have been translated into lifesaving antiviral drugs. Yet, we have an incomplete understanding of the cells in which HIV-1 replicates in untreated individuals and persists in during antiretroviral therapy.

Methods: In this review we discuss how viral entry phenotypes have been characterized and the insights they have revealed about the target cells supporting HIV-1 replication. Read More

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http://dx.doi.org/10.2174/1570162X16666171222105721DOI Listing
April 2019
7 Reads

Impact of Different Antiretroviral Strategies on Total HIV-DNA Level in Virologically Suppressed HIV-1 Infected Patients.

Curr HIV Res 2017 ;15(6):448-455

Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Via Massarenti, 9, Bologna, Italy.

Background: Total HIV-DNA load in peripheral blood cell (PBMCs) reflects the global viral reservoir that seems not to be affected by antiretroviral treatment. However, some studies reported a different permeability of different drugs in cellular compartments.

Objective: To investigate the relation between the amount of total HIV-1 DNA and different treatment strategies. Read More

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http://dx.doi.org/10.2174/1570162X16666171206121026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876918PMC
April 2019
30 Reads