5 results match your criteria Current Drug Therapy[Journal]

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Novel Oral Anticoagulants for Venous Thromboembolism with Special Emphasis on Risk of Hemorrhagic Complications and Reversal Agents.

Curr Drug ther 2016 Apr;11(1):3-20

University of Missouri, Kansas City School of Medicine, Kansas City, MO,USA.

Warfarin was the only oral anticoagulant available for the treatment of venous thromboembolism for about half a century until the recent approval of novel oral agents dabigatran, rivoraxaban and apixaban. This presents new classes of medications less cumbersome to use. They do not require frequent laboratory monitoring or have nurmerous drug interactions. Read More

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http://dx.doi.org/10.2174/1574885511666160421145036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003057PMC
April 2016
24 Reads

Efficacy of Duloxetine in Patients with Chronic Pain Conditions.

Curr Drug ther 2011 Nov;6(4):296-303

Lilly Research Laboratories, Indianapolis, IN 46285, USA.

The primary objective of this study is to review the efficacy of duloxetine in treating chronic pain using the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations for clinical significance across chronic pain states. These include pain intensity, patient ratings of overall improvement, physical functioning, and mental functioning. This review comprised the side-by-side analyses of 12 double-blind, placebo-controlled trials of duloxetine in patients with chronic pain (diabetic peripheral neuropathic pain, fibromyalgia, chronic pain due to osteoarthritis, and chronic low back pain). Read More

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http://dx.doi.org/10.2174/157488511798109592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412202PMC
November 2011
28 Reads

Enhancing Immunogenicity of Cancer Vaccines: QS-21 as an Immune Adjuvant.

Curr Drug ther 2011 Aug;6(3):207-212

Associate Attending Physician, Genitourinary Oncology Service, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, NY, and Associate Professor of Medicine, Weill-Cornell Medical College, NY.

Saponins comprise a class of plant natural products that incorporate a lipophilic terpenoid core, to which is appended one or more carbohydrate residues. They are amphiphilic molecules and often exhibit toxic biological profiles, likely as a result of their roles as vital components in protective coatings to defend against phytopathogen infection and insect predation. The most notable of adjuvant-active saponins investigated for vaccine development come from the Chilean Soapbark Tree, (i. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248601PMC
August 2011
16 Reads

Adenoviral vector-based strategies for cancer therapy.

Curr Drug ther 2009 May;4(2):117-138

Department of Comparative Pathobiology, and Bindley Bioscience Center, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.

Definitive treatment of cancer has eluded scientists for decades. Current therapeutic modalities like surgery, chemotherapy, radiotherapy and receptor-targeted antibodies have varied degree of success and generally have moderate to severe side effects. Gene therapy is one of the novel and promising approaches for therapeutic intervention of cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771947PMC
May 2009
21 Reads

Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.

Curr Drug ther 2008 Sep;3(3):190-203

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.

The ability of clinicians to wage an effective war against many bacterial infections is increasingly being hampered by skyrocketing rates of antibiotic resistance. Indeed, antibiotic resistance is a significant problem for treatment of diseases caused by virtually all known infectious bacteria. The gastric pathogen Helicobacter pylori is no exception to this rule. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136193PMC
September 2008
13 Reads
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