3,258 results match your criteria Current Drug Targets [Journal]


Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: a Review.

Curr Drug Targets 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur. Malaysia.

Metabolic syndrome (MetS) involves a cluster of five conditions, i.e. obesity, hyperglycaemia, hypertension, hypertriglyceridemia and low high-density lipoprotein (HDL) cholesterol. Read More

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http://dx.doi.org/10.2174/1389450120666190405172524DOI Listing

Silicon Quantum dots: Promising theranostic probes for the future.

Curr Drug Targets 2019 Apr 5. Epub 2019 Apr 5.

Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad 678557, Kerala. India.

Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments taken place in the biomedical field. The new generation nanomaterials like Quantum dots are gaining much importance. Read More

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http://dx.doi.org/10.2174/1389450120666190405152315DOI Listing
April 2019
1 Read
3.021 Impact Factor

Anti-TNF and postoperative complications in abdominal Crohn's disease surgery.

Curr Drug Targets 2019 Apr 4. Epub 2019 Apr 4.

IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Centre, Rozzano, Milan. Italy.

Background: Biological therapy with anti-tumour necrosis factor (TNF)-α agents revolutionised the treatment of inflammatory bowel disease over the last decades. However, there may be an increased risk of postoperative complications in Crohn's disease (CD) patients treated with anti-TNF-α agents prior to abdominal surgery.

Objective: To evaluate the effects of preoperative anti-TNF-α therapy on the incidence of complications after surgery. Read More

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http://dx.doi.org/10.2174/1389450120666190404144048DOI Listing
April 2019
2 Reads

Anti-tumor drug targets analysis: current insight and future prospect.

Curr Drug Targets 2019 Apr 2. Epub 2019 Apr 2.

Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province. China.

The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually discovered that the essence of cell carcinogenesis is the infinite proliferation of cells caused by the disorder of cell signal transduction pathways, followed by a major shift in the concept of anti-tumor drugs research and development. Read More

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http://dx.doi.org/10.2174/1389450120666190402145325DOI Listing
April 2019
1 Read

Targeting p53-MDM2 interaction using small molecule inhibitors and the challenges needed to be addressed.

Curr Drug Targets 2019 Apr 2. Epub 2019 Apr 2.

Department of Cellular and Molecular Biology, Faculty of Science, University of Isfahan. Iran.

MDM2 protein is the core negative regulator of p53 that maintains the cellular levels of p53 at a low level in normal cells. Mutation of the TP53 gene accounts for 50% of all human cancers. In the remaining malignancies with wild-type TP53, p53 function is inhibited through other mechanisms. Read More

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http://dx.doi.org/10.2174/1389450120666190402120701DOI Listing
April 2019
2 Reads

Current understanding of Group A Streptococcal biofilms.

Curr Drug Targets 2019 Apr 4. Epub 2019 Apr 4.

School of Chemistry and Molecular Bioscience, and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong. Australia.

Background: It has been proposed that GAS may be able to exist as biofilms. Biofilms are microbial communities that aggregate on a surface, and exist within a self-produced matrix of extracellular polymeric substances. Biofilms offer bacteria an increased survival advantage, in which bacteria persist, and resist host immunity and antimicrobial treatment. Read More

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http://dx.doi.org/10.2174/1389450120666190405095712DOI Listing
April 2019
2 Reads

Anti-TNF and pouch surgery for ulcerative colitis: the ones who blame for more complications?

Curr Drug Targets 2019 Mar 28. Epub 2019 Mar 28.

Department of Abdominal Surgery, University Hospitals Leuven, KU Leuven, Leuven. Belgium.

Since the approval in 2005 of anti-TNF drugs for the treatment of ulcerative colitis, concerns have been raised about the potential detrimental effect of these agents on postoperative infectious complications related to pouch surgery. Data on this topic are controversial and mostly derived from retrospective underpowered cohort studies largely affected by relevant bias. Three meta-analyses have been published with contradictory results. Read More

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http://dx.doi.org/10.2174/1389450120666190328153200DOI Listing

Vedolizumab in the perioperative management of inflammatory bowel disease.

Curr Drug Targets 2019 Mar 25. Epub 2019 Mar 25.

Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota. United States.

Background: The isolated effect of vedolizumab on increased postoperative complications remains debated, similar to the controversial data on anti-TNF and postoperative complications.

Objective: Determine the risk of vedolizumab on postoperative complications.

Method: A review of the literature available to date on studies comparing postoperative outcomes in vedolizumab-treated versus non-vedolizumab-treated patients was performed. Read More

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http://dx.doi.org/10.2174/1389450120666190325130142DOI Listing
March 2019
1 Read

Steroids and postoperative complications in IBD.

Curr Drug Targets 2019 Mar 20. Epub 2019 Mar 20.

Gastroenterology Division Gastroenterology and Hepatology Department Hospital Ramón y Cajal, 28034 Madrid. Spain.

Corticosteroids are frequently used in the management of Inflammatory Bowel Disease. Although they can be very useful, their potential adverse effects have to be kept in mind. One of the situations in which these drugs should be avoided, if possible, is the perioperative setting. Read More

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http://dx.doi.org/10.2174/1389450120666190320122939DOI Listing
March 2019
5 Reads

Prevention of postoperative recurrence in Crohn's disease: tailoring treatment to patient profile.

Curr Drug Targets 2019 03 19. Epub 2019 Mar 19.

IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Institute, Milan. Italy.

Crohn's disease (CD) is an immune mediated condition characterized by transmural inflammation of the gut tissue, associated with progressive bowel damage often leading to surgical intervention. As operative resection of the damaged segment is not curative, a majority of patients undergoing intestinal resections for complicated CD present with disease recurrence within 3 years after intervention. Postoperative recurrence can be defined as endoscopic, clinical, radiological or surgical. Read More

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http://www.eurekaselect.com/170857/article
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http://dx.doi.org/10.2174/1389450120666190320110809DOI Listing
March 2019
9 Reads

Molecular Aspects of Melatonin Treatment in Tinnitus; a Review.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Razi Drug Research Center, Iran University of Medical Sciences, Tehran. Iran.

Tinnitus is a hearing disorder characterized by the perception of sound without external acoustic stimuli, which is caused by damage to the auditory system in response to excessive levels of noise, ototoxic agents and aging process. Neural plasticity, oxidative/nitrosative stress and apoptosis play important roles in the pathogenesis of tinnitus. The expression of neural plasticity related to excessive glutamatergic neurotransmission leads to generation of abnormal sound in one's ears or head. Read More

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http://dx.doi.org/10.2174/1389450120666190319162147DOI Listing
March 2019
1 Read
3.021 Impact Factor

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. India.

Oral cancer (OC) is a serious and a growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in expected number of new cases in US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Read More

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http://www.eurekaselect.com/170833/article
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http://dx.doi.org/10.2174/1389450120666190319125734DOI Listing
March 2019
7 Reads

The use of naltrexone in dermatology. Current evidence and future directions.

Curr Drug Targets 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Medical University of Warsaw, Warsaw. Poland.

Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. In a dose 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1-5 mg of drug per day, naltrexone demonstrates immunomodulatory action i. Read More

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http://dx.doi.org/10.2174/1389450120666190318121122DOI Listing
March 2019
14 Reads

The Computational Methods in Drug Targets Discovery.

Authors:
Hao Lin

Curr Drug Targets 2019 ;20(5):479-480

Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and Technology, Center for Informational Biology University of Electronic Science and Technology of China, Chengdu, China.

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http://dx.doi.org/10.2174/138945012005190218093921DOI Listing
January 2019

NOB1: A potential biomarker or target in cancer.

Curr Drug Targets 2019 Mar 8. Epub 2019 Mar 8.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN. China.

Human NIN1/RPN12 binding protein 1 homolog (NOB1), an RNA binding protein, is expressed ubiquitously in normal tissues such as the lung, liver, and spleen. Its core physiological function is to regulate protease activities and participate in maintaining RNA metabolism and stability. NOB1 is overexpressed in a variety of cancers, including pancreatic cancer, non-small cell lung cancer, ovarian cancer, prostate carcinoma, osteosarcoma, papillary thyroid carcinoma, colorectal cancer, and glioma. Read More

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http://dx.doi.org/10.2174/1389450120666190308145346DOI Listing
March 2019
8 Reads

Significance and Mechanisms of P-glycoprotein in Central Nervous System Diseases.

Curr Drug Targets 2019 Mar 8. Epub 2019 Mar 8.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009. China.

P-glycoprotein (P-gp) is a member of ATP-binding cassette (ABC) transporter family. Because of its characteristic luminal surface location, high transport potency and structural specificity, P-gp is regarded as a selective gatekeeper of blood brain barrier (BBB) to prevent the entry of toxins or unwanted substances into the brain. In recent years, increasing evidence has shown that P-gp is involved in immune inflammatory response in central nervous system (CNS) disorders by regulating microglia activation, and mediating immune cell migration. Read More

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http://dx.doi.org/10.2174/1389450120666190308144448DOI Listing
March 2019
3.021 Impact Factor

Trans-sialidase associated with atherosclerosis : defining the identity of a key enzyme involved in the pathology.

Curr Drug Targets 2019 Mar 7. Epub 2019 Mar 7.

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow. Russian Federation.

Atherosclerosis is associated with increased trans-sialidase activity, which can be detected in atherosclerosis patients' blood plasma. The likely involvement in the disease pathogenesis made this activity an interesting research subject, and the enzyme that may performs such activity had been isolated and characterized in terms of substrate specificity and enzymatic properties. It was found that the enzyme had distinct optimum pH values, and its activity was enhanced by the presence of Ca2+ ions. Read More

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http://dx.doi.org/10.2174/1389450120666190308111619DOI Listing
March 2019
1 Read

Nanotechnology Advanced Strategies for the Management of Diabetes Mellitus.

Curr Drug Targets 2019 Mar 6. Epub 2019 Mar 6.

Pharmaceutical Technology Department, National Research Centre, Dokki, Cairo. Egypt.

Background: Today's medications available for the management of diabetes mellitus are inconvenient and have some limitations. Thus, investigations for novel approaches are needed to deliver and target antidiabetics safely to the site of action.

Objective: The present review emphasizes the limitations of conventional antidiabetics and provides the recent progresses of nanotechnology in the treatment of DM with special highlighting on novel nano-carriers methodologies employed as antidiabetic drug delivery systems. Read More

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http://www.eurekaselect.com/170520/article
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http://dx.doi.org/10.2174/1389450120666190307101642DOI Listing
March 2019
10 Reads

MicroRNAs as potential diagnostic and prognostic biomarkers in hepatocellular carcinoma.

Curr Drug Targets 2019 Mar 6. Epub 2019 Mar 6.

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad. Iran.

Hepatocellular carcinoma (HCC) is a common cancer, and the second most common cause of cancer-associated death globally. One of the major reasons for this high rate of mortality is a failure to make an early diagnosis. The average survival in untreated HCC patients is estimated to be approximately three months. Read More

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http://dx.doi.org/10.2174/1389450120666190307095720DOI Listing
March 2019
1 Read

Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression.

Curr Drug Targets 2019 Feb 27. Epub 2019 Feb 27.

Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, . China.

HACE1 belongs to the family of HECT domain-containing E3 ligases, which plays an important role in the occurrence, invasion and metastatic process in many human malignancies. HACE1 is a tumor suppressor gene that is reduced in most cancer tissues compared to adjacent normal tissue. The loss or knocking out of HACE1 leads to enhanced tumor growth, invasion, and metastasis; in contrast, the overexpression of HACE1 can inhibit the development of tumors. Read More

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http://dx.doi.org/10.2174/1389450120666190227184654DOI Listing
February 2019
2 Reads
3.021 Impact Factor

Targeting DNA Double-Strand Break (DSB) Repair to counteract tumor radio-resistance.

Curr Drug Targets 2019 Feb 22. Epub 2019 Feb 22.

Department of oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University . China.

During the last decade, advances of radiotherapy (RT) have been made in the clinical practice of cancer treatment. RT exerts its anticancer effect mainly via leading to the DNA double-strand break (DSB), which is one of the most toxic DNA damages. Non-homologous end joining (NHEJ) and homologous recombination (HR) are two major DSB repair pathways in human cells. Read More

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http://dx.doi.org/10.2174/1389450120666190222181857DOI Listing
February 2019
11 Reads

Toll like receptors as a novel therapeutic target for natural products against chronic diseases.

Curr Drug Targets 2019 Feb 22. Epub 2019 Feb 22.

Post Graduate & Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut, Kerala, 680 555. India.

Toll-like receptors (TLR) are one among the initial responders of the immune system which participate in the activation inflammatory processes. Several different types of TLR such as TLR2, TLR4, TLR7 and TLR9 have been identified in various cell types, each having distinct ligands like lipids, lipoproteins, nucleic acids and proteins. Thought its prime concern is xenobiotic defences, TLR signalling has also recognized as an activator of inflammation and associated development of chronic degenerative disorders (CDDs) including obesity, type 2 diabetes mellitus (T2DM), fatty liver disease, cardiovascular and neurodegenerative disorders as well as various types of cancers. Read More

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http://dx.doi.org/10.2174/1389450120666190222181506DOI Listing
February 2019
2 Reads
3.021 Impact Factor

Targeting Water in Brain: Role of Aquaporin-4 in Ischemic Brain Edema.

Curr Drug Targets 2019 Feb 13. Epub 2019 Feb 13.

Neuroscience and Neuroengineering Research Center, Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200000. China.

Brain edema primarily occurs as a consequence of various cerebral injuries including ischemia-induced brain damage. Excessive accumulation of brain water content causes a gradual expansion of brain parenchyma, decreased blood flow and increased intracranial pressure and, ultimately, cerebral herniation and death. Current clinical treatments for ischemic edema are very limited, therefore, it is urgent to develop a novel treatment strategy. Read More

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http://dx.doi.org/10.2174/1389450120666190214115309DOI Listing
February 2019
1 Read

Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019
1 Read
3.021 Impact Factor

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019
4 Reads
3.021 Impact Factor

Potential Therapeutic Applications of P2 Receptor Antagonists: from Bench to Clinical Trials.

Curr Drug Targets 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Technological Development in Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-360. Brazil.

Background: Extracellular purines and pyrimidines have important physiological functions in mammals. Purines and pyrimidines act on P1 and P2 purinergic receptors, which are widely expressed in the plasma membrane in various cell types. P2 receptors act as important therapeutic targets and are associated with several disorders, such as pain, neurodegeneration, cancer, inflammation, and thrombosis. Read More

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http://dx.doi.org/10.2174/1389450120666190213095923DOI Listing
February 2019
1 Read

Insight of Pain modulation: nociceptors sensitization and therapeutic targets.

Curr Drug Targets 2019 Jan 30. Epub 2019 Jan 30.

College of Pharmacy, Seoul National University, Seoul. Korea.

Pain is a complex multidimensional concept that facilitates the initiation of the signaling cascade in response to any noxious stimuli. Action potential generation in the peripheral nociceptor terminal and its transmission through various types of nociceptors corresponding to mechanical, chemical or thermal stimuli leads to the activation of receptors and further neuronal processing produces sensation of pain. Numerous types of receptors are activated in pain sensation which varies in their signaling pathway. Read More

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http://dx.doi.org/10.2174/1389450120666190131114244DOI Listing
January 2019
2 Reads

A review of preclinical experiments toward targeting M2 macrophages in prostate cancer.

Curr Drug Targets 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran. Iran.

Prostate cancer is a malignant cancer leading to high mortality in the male population. The existence of suppressive cells referred to as tumor-associated macrophages (TAM) is a major obstacle in prostate cancer immunotherapy. TAMs contribute to the immunosuppressive microenvironment that promote tumor growth and metastasis. Read More

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http://dx.doi.org/10.2174/1389450120666190123141553DOI Listing
January 2019
3.021 Impact Factor

Age-related macular degeneration: current knowledge of zinc metalloproteinases involvement.

Curr Drug Targets 2019 Jan 21. Epub 2019 Jan 21.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa. Italy.

Background: Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. The disease is characterized by photoreceptor loss in the macula and reduced retinal pigment epithelium (RPE) function, associated with matrix degradation, cell proliferation, neovascularization and inflammation. Matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) play a critical role in the physiology of extracellular membrane (ECM) turnover and, in turn, in ECM pathologies, such as AMD. Read More

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http://dx.doi.org/10.2174/1389450120666190122114857DOI Listing
January 2019
4 Reads

Nanonetworks in Biomedical Applications.

Curr Drug Targets 2019 Jan 15. Epub 2019 Jan 15.

University of Nebraska-Lincoln, Lincoln, Nebraska. United States.

By interconnecting nanomachines and forming nanonetworks, the capacities of single nanomachines are expected to be enhanced as the ensuing information exchange will allow them to cooperate towards a common goal. Nowadays, systems normally use electromagnetic signals to encode, send and receive information, however, in a novel communication paradigm, molecular transceivers, channel models or protocols use molecules. This article presents the current developments in nanomachines along with their future architecture to better understand nanonetwork scenarios in biomedical applications. Read More

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http://www.eurekaselect.com/169016/article
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http://dx.doi.org/10.2174/1389450120666190115152613DOI Listing
January 2019
3 Reads

Photopolymerizable Resins for 3D-Printing Tissue Engineered Implants

Curr Drug Targets 2019 01 14. Epub 2019 Jan 14.

Department of Plastic Surgery, The Ohio State University, Columbus, OH 43210. United States.

With the advent of inexpensive and highly accurate 3D printing devices, a tremendous flurry of research activity has been unleashed into new resorbable, polymeric materials that can be printed using three approaches: hydrogels for bioprinting and bioplotting, sintered polymer powders, and solid cured (photocrosslinked) resins. Additionally, there is a race to understand the role of extracellular matrix components and cell signaling molecules and to fashion ways to incorporate these materials into resorbable implants. These chimeric materials along with microfluidic devices to study organs or create labs on chips, are all receiving intense attention despite the limited number of polymer systems that can accommodate the biofabrication processes necessary to render these constructs. Read More

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http://dx.doi.org/10.2174/1389450120666190114122815DOI Listing
January 2019
3 Reads

Implications of fibroblast growth factor (FGF) in cancer: From prognostics to therpeutic applications.

Curr Drug Targets 2019 Jan 12. Epub 2019 Jan 12.

Molecular Medicine Department, Pasteur Institute of Iran, 69th Pasteur Avenue, Kargar Street, Tehran. Iran.

Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apaoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplifications, fusions, and mutations, changes in tumor-stromal cells interactions, associates with the development and progression of cancer. Read More

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http://www.eurekaselect.com/168947/article
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http://dx.doi.org/10.2174/1389450120666190112145409DOI Listing
January 2019
11 Reads

Editorial.

Curr Drug Targets 2019 ;20(2):145

Department of Psychiatry International Islamic University Kuantan, Pahang, Malaysia.

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http://dx.doi.org/10.2174/138945012002181203145147DOI Listing
January 2019
2 Reads

Recent review on subclass B1 metallo-β-lactamases inhibitors: Sword for Antimicrobial Resistance.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Shivalik college of Pharmacy. India.

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations posing a global threat to human health. The production of metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Read More

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http://dx.doi.org/10.2174/1389450120666181217101812DOI Listing
December 2018
2 Reads

The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

FIOCRUZ, Rio de Janeiro. Brazil.

Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More

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http://dx.doi.org/10.2174/1389450120666181217095323DOI Listing
December 2018
5 Reads

Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Division of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. United States.

Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. Read More

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http://dx.doi.org/10.2174/1389450120666181217111500DOI Listing
December 2018
2 Reads

Cellular Senescence and Anti-Cancer Therapy.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058. China.

Background: Cellular senescence is generally understood as permanent cell cycle arrest stemming from different causes. The mechanism of cellular senescence-induced cell cycle arrest is complex, involving interactions between telomere shortening, inflammations and cellular stresses. In recent years, a growing number of studies have revealed that cellular senescence could mediate the cancer progression of neighboring cells, but this idea is controversial and contradictory evidence argues that cellular senescence also contributes to tumor suppression. Read More

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http://dx.doi.org/10.2174/1389450120666181217100833DOI Listing
December 2018
1 Read

The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain.

Authors:
Manuel Yepes

Curr Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center; Atlanta, GA. United States.

The plasminogen activation (PA) system was originally thought to exclusively promote the degradation of fibrin by catalyzing the conversion of plasminogen into plasmin via two serine proteinases: tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). However, experimental evidence accumulated over the last 30 years indicates that tPA and uPA are also found in the central nervous system (CNS), where they have a plethora of functions that not always require plasmin generation or fibrin degradation. For example, plasminogen-dependent and -independent effects of tPA and uPA play a central role in the pathophysiological events that underlie one of the leading causes of mortality and disability in the world: cerebral ischemia. Read More

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http://dx.doi.org/10.2174/1389450120666181211144550DOI Listing
December 2018
11 Reads

The impact of statin therapy on survival of patients with gastrointestinal cancer.

Curr Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad. Iran.

Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that may play an important role in the evolution of cancers, due to their effects on cancer cell metabolism. Statins effect several potential pathways, including: cell proliferation, angiogenesis, apoptosis and metastasis. The number of trials assessing the putative clinical benefits of statins in cancer is increasing. Read More

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http://dx.doi.org/10.2174/1389450120666181211165449DOI Listing
December 2018
3 Reads

Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases

Curr Drug Targets 2018 12 11. Epub 2018 Dec 11.

Department of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; and Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081. China.

Owning the high incidence and disability rate in the past decades, to be expected, cardiovascular diseases (CVDs) have become one of the leading death causes worldwide. Currently, induced pluripotent stem cells (iPSCs), with the potential to form fresh myocardium and improve the functions of damaged hearts, have been studied widely in experimental CVD therapy. Moreover, iPSC-derived cardiomyocytes (CMs), as novel disease models, play a significant role in drug screening, drug safety assessment, along with the exploration of pathological mechanisms of diseases. Read More

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http://dx.doi.org/10.2174/1389450120666181211164147DOI Listing
December 2018
2 Reads

Heat shock proteins (HSPs): A novel target for cancer metastasis prevention.

Curr Drug Targets 2018 Dec 10. Epub 2018 Dec 10.

Scientific Officer in charge, Cell and Tissue Culture Department, Micro labs, Bangalore. India.

Background: Heat shock proteins (HSPs) are predominant molecular chaperone which is actively involved in the protein folding; which is essential in protecting the structure and functioning of proteins during various stress conditions. Though HSPs have important physiological roles, they have been well known for their roles in various pathogenic conditions such as carcinogenesis; however, limited literature has consolidated its potential as an anti-metastatic drug target.

Objectives: The present review outlines the role of different HSPs on cancer progression and metastasis; possible role of HSP inhibitors as anti-neoplastic agents are also discussed. Read More

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http://dx.doi.org/10.2174/1389450120666181211111815DOI Listing
December 2018
4 Reads
3.112 Impact Factor

Understanding Membrane Protein Drug Targets in Computational Perspective.

Curr Drug Targets 2019 ;20(5):551-564

School of Information Science and Technology, Northeast Normal University, Changchun, China.

Membrane proteins play crucial physiological roles in vivo and are the major category of drug targets for pharmaceuticals. The research on membrane protein is a significant part in the drug discovery. The biological process is a cycled network, and the membrane protein is a vital hub in the network since most drugs achieve the therapeutic effect via interacting with the membrane protein. Read More

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http://dx.doi.org/10.2174/1389450120666181204164721DOI Listing
January 2019
25 Reads

Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.

Curr Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

Graduate Program in Cellular and Molecular Biology. The Pontifical Catholic University of Rio Grande do Sul (PUCRS). Av. Ipiranga, 6681 Porto Alegre/RS 90619-900 . Brazil.

Background: Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-cycle progression. The elucidation of the CDK2 structure paved the way to investigate the molecular basis for inhibition of this enzyme, with the coordinated efforts combining crystallography with functional studies.

Objective: Our goal here is to review recent functional and structural studies directed to understanding the role of CDK2 in cancer and senescence. Read More

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http://dx.doi.org/10.2174/1389450120666181204165344DOI Listing
December 2018
35 Reads

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets.

Curr Drug Targets 2018 12 4. Epub 2018 Dec 4.

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522. Australia.

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation system (PAS) is associated with a wide range of physiological and pathophysiological states involving fibrinolysis, inflammation and tissue remodeling. Various components of the PAS are implicated in the pathophysiology of RA. Read More

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http://dx.doi.org/10.2174/1389450120666181204164140DOI Listing
December 2018
3 Reads

Opportunities of bacterial cellulose to treat epithelial tissues.

Curr Drug Targets 2018 11 28. Epub 2018 Nov 28.

Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, 07743 Jena. Germany.

In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Read More

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http://dx.doi.org/10.2174/1389450120666181129092144DOI Listing
November 2018
9 Reads

Saccharomyces cerevisiae (Baker's Yeast) as an Interfering RNA Expression and Delivery System.

Curr Drug Targets 2018 Nov 26. Epub 2018 Nov 26.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, South Bend, IN. United States.

The broad application of RNA interference for disease prevention is dependent upon production of dsRNA in an economically feasible, scalable, and sustainable fashion, as well as the identification of safe and effective methods for RNA delivery. Current research has sparked interest in the use of Saccharomyces cerevisiae for these applications. This review examines the potential for commercial development of yeast interfering RNA expression and delivery systems. Read More

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http://dx.doi.org/10.2174/1389450120666181126123538DOI Listing
November 2018
23 Reads

Potential Therapeutic Agents Against Par-4 Target for Cancer Treatment: Where Are We Going?

Curr Drug Targets 2019 ;20(6):635-654

Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil.

One of the greatest challenges of cancer therapeutics nowadays is to find selective targets successfully. Prostate apoptosis response-4 (Par-4) is a selective tumor suppressor protein with an interesting therapeutic potential due to its specificity on inducing apoptosis in cancer cells. Par-4 activity and levels can be downregulated in several tumors and cancer cell types, indicating poor prognosis and treatment resistance. Read More

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http://dx.doi.org/10.2174/1389450120666181126122440DOI Listing
January 2019
3 Reads

Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development.

Curr Drug Targets 2019 ;20(6):668-678

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Hypoxia, which occurs in most cancer cases, disrupts the efficacy of anticarcinogens. Fortunately, hypoxia itself is a potential target for cancer treatment. Hypoxia-activated prodrugs (HAPs) can be selectively activated by reductase under hypoxia. Read More

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http://dx.doi.org/10.2174/1389450120666181123122406DOI Listing
January 2019
22 Reads

Functional Diversity of Quorum Sensing Receptors in Pathogenic Bacteria: Interspecies, Intraspecies and Interkingdom Level.

Curr Drug Targets 2019 ;20(6):655-667

Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea.

The formation of biofilm by pathogenic bacteria is considered as one of the most powerful mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed as a structural adherent over the surfaces of host, food and equipments etc. and is further functionally coordinated by certain chemicals produced itself. Read More

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http://dx.doi.org/10.2174/1389450120666181123123333DOI Listing
January 2019
13 Reads

Three-Dimensional Manufactured Supports for Breast Cancer Stem Cell Population Characterization.

Curr Drug Targets 2018 Nov 21. Epub 2018 Nov 21.

New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona. Spain.

Breast Cancer (BC) is the most common cancer among women as well as it is the second cause of female deaths. When the tumor is not correctly eradicated there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anti-cancer therapies being in part responsible of relapse tumor and metastasis. Read More

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http://dx.doi.org/10.2174/1389450120666181122113300DOI Listing
November 2018
11 Reads