3,235 results match your criteria Current Drug Targets [Journal]


Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019

Potential Therapeutic Applications of P2 Receptor Antagonists: from Bench to Clinical Trials.

Curr Drug Targets 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Technological Development in Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-360. Brazil.

Background: Extracellular purines and pyrimidines have important physiological functions in mammals. Purines and pyrimidines act on P1 and P2 purinergic receptors, which are widely expressed in the plasma membrane in various cell types. P2 receptors act as important therapeutic targets and are associated with several disorders, such as pain, neurodegeneration, cancer, inflammation, and thrombosis. Read More

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http://dx.doi.org/10.2174/1389450120666190213095923DOI Listing
February 2019

Insight of Pain modulation: nociceptors sensitization and therapeutic targets.

Curr Drug Targets 2019 Jan 30. Epub 2019 Jan 30.

College of Pharmacy, Seoul National University, Seoul. Korea.

Pain is a complex multidimensional concept that facilitates the initiation of the signaling cascade in response to any noxious stimuli. Action potential generation in the peripheral nociceptor terminal and its transmission through various types of nociceptors corresponding to mechanical, chemical or thermal stimuli leads to the activation of receptors and further neuronal processing produces sensation of pain. Numerous types of receptors are activated in pain sensation which varies in their signaling pathway. Read More

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http://dx.doi.org/10.2174/1389450120666190131114244DOI Listing
January 2019
1 Read

A review of preclinical experiments toward targeting M2 macrophages in prostate cancer.

Curr Drug Targets 2019 Jan 23. Epub 2019 Jan 23.

Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran. Iran.

Prostate cancer is a malignant cancer leading to high mortality in the male population. The existence of suppressive cells referred to as tumor-associated macrophages (TAM) is a major obstacle in prostate cancer immunotherapy. TAMs contribute to the immunosuppressive microenvironment that promote tumor growth and metastasis. Read More

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http://dx.doi.org/10.2174/1389450120666190123141553DOI Listing
January 2019
3.021 Impact Factor

Age-related macular degeneration: current knowledge of zinc metalloproteinases involvement.

Curr Drug Targets 2019 Jan 21. Epub 2019 Jan 21.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa. Italy.

Background: Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. The disease is characterized by photoreceptor loss in the macula and reduced retinal pigment epithelium (RPE) function, associated with matrix degradation, cell proliferation, neovascularization and inflammation. Matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) play a critical role in the physiology of extracellular membrane (ECM) turnover and, in turn, in ECM pathologies, such as AMD. Read More

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http://dx.doi.org/10.2174/1389450120666190122114857DOI Listing
January 2019
1 Read

Nanonetworks in Biomedical Applications.

Curr Drug Targets 2019 Jan 15. Epub 2019 Jan 15.

University of Nebraska-Lincoln, Lincoln, Nebraska. United States.

By interconnecting nanomachines and forming nanonetworks, the capacities of single nanomachines are expected to be enhanced as the ensuing information exchange will allow them to cooperate towards a common goal. Nowadays, systems normally use electromagnetic signals to encode, send and receive information, however, in a novel communication paradigm, molecular transceivers, channel models or protocols use molecules. This article presents the current developments in nanomachines along with their future architecture to better understand nanonetwork scenarios in biomedical applications. Read More

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http://www.eurekaselect.com/169016/article
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http://dx.doi.org/10.2174/1389450120666190115152613DOI Listing
January 2019
3 Reads

Photopolymerizable Resins for 3D-Printing Tissue Engineered Implants

Curr Drug Targets 2019 01 14. Epub 2019 Jan 14.

Department of Plastic Surgery, The Ohio State University, Columbus, OH 43210. United States.

With the advent of inexpensive and highly accurate 3D printing devices, a tremendous flurry of research activity has been unleashed into new resorbable, polymeric materials that can be printed using three approaches: hydrogels for bioprinting and bioplotting, sintered polymer powders, and solid cured (photocrosslinked) resins. Additionally, there is a race to understand the role of extracellular matrix components and cell signaling molecules and to fashion ways to incorporate these materials into resorbable implants. These chimeric materials along with microfluidic devices to study organs or create labs on chips, are all receiving intense attention despite the limited number of polymer systems that can accommodate the biofabrication processes necessary to render these constructs. Read More

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http://dx.doi.org/10.2174/1389450120666190114122815DOI Listing
January 2019
2 Reads

Implications of fibroblast growth factor (FGF) in cancer: From prognostics to therpeutic applications.

Curr Drug Targets 2019 Jan 12. Epub 2019 Jan 12.

Molecular Medicine Department, Pasteur Institute of Iran, 69th Pasteur Avenue, Kargar Street, Tehran. Iran.

Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apaoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplifications, fusions, and mutations, changes in tumor-stromal cells interactions, associates with the development and progression of cancer. Read More

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http://www.eurekaselect.com/168947/article
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http://dx.doi.org/10.2174/1389450120666190112145409DOI Listing
January 2019
4 Reads

Editorial.

Curr Drug Targets 2019 ;20(2):145

Department of Psychiatry International Islamic University Kuantan, Pahang, Malaysia.

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http://dx.doi.org/10.2174/138945012002181203145147DOI Listing
January 2019
2 Reads

Recent review on subclass B1 metallo-β-lactamases inhibitors: Sword for Antimicrobial Resistance.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Shivalik college of Pharmacy. India.

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations posing a global threat to human health. The production of metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Read More

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http://dx.doi.org/10.2174/1389450120666181217101812DOI Listing
December 2018
1 Read

The need to consider context in the evaluation of anti-infectious and immunomodulatory effects of Vitamin A and its derivatives.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

FIOCRUZ, Rio de Janeiro. Brazil.

Vitamin A and its derivatives (retinoids) act as potent regulators in many aspects of mammalian reproduction, development, repair, and maintenance of differentiated tissue functioning. Unlike other vitamins, Vitamin A and retinoids, which have hormonal actions, present significant toxicity, which plays roles in clinically relevant situations, such as hypervitaminosis A and retinoic acid ("differentiation") syndrome. Although clinical presentation is conspicuous in states of insufficient or excessive Vitamin A and retinoid concentration, equally relevant effects on host resistance to specific infectious agents, and in the general maintenance of immune homeostasis, may go unnoticed, because their expression requires either pathogen exposure or the presence of inflammatory co-morbidities. Read More

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http://dx.doi.org/10.2174/1389450120666181217095323DOI Listing
December 2018
2 Reads

Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Division of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. United States.

Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. Read More

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http://dx.doi.org/10.2174/1389450120666181217111500DOI Listing
December 2018
2 Reads

Cellular Senescence and Anti-Cancer Therapy.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058. China.

Background: Cellular senescence is generally understood as permanent cell cycle arrest stemming from different causes. The mechanism of cellular senescence-induced cell cycle arrest is complex, involving interactions between telomere shortening, inflammations and cellular stresses. In recent years, a growing number of studies have revealed that cellular senescence could mediate the cancer progression of neighboring cells, but this idea is controversial and contradictory evidence argues that cellular senescence also contributes to tumor suppression. Read More

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http://dx.doi.org/10.2174/1389450120666181217100833DOI Listing
December 2018
1 Read

The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain.

Authors:
Manuel Yepes

Curr Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center; Atlanta, GA. United States.

The plasminogen activation (PA) system was originally thought to exclusively promote the degradation of fibrin by catalyzing the conversion of plasminogen into plasmin via two serine proteinases: tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). However, experimental evidence accumulated over the last 30 years indicates that tPA and uPA are also found in the central nervous system (CNS), where they have a plethora of functions that not always require plasmin generation or fibrin degradation. For example, plasminogen-dependent and -independent effects of tPA and uPA play a central role in the pathophysiological events that underlie one of the leading causes of mortality and disability in the world: cerebral ischemia. Read More

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http://dx.doi.org/10.2174/1389450120666181211144550DOI Listing
December 2018
8 Reads

The impact of statin therapy on survival of patients with gastrointestinal cancer.

Curr Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad. Iran.

Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that may play an important role in the evolution of cancers, due to their effects on cancer cell metabolism. Statins effect several potential pathways, including: cell proliferation, angiogenesis, apoptosis and metastasis. The number of trials assessing the putative clinical benefits of statins in cancer is increasing. Read More

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http://www.eurekaselect.com/168282/article
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http://dx.doi.org/10.2174/1389450120666181211165449DOI Listing
December 2018
3 Reads

Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases.

Curr Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; and Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081. China.

Cardiovascular disease (CVD) is the number one killer of human beings which has long become the disease with the highest incidence and disability rate in modern society. Currently induced pluripotent stem cells (iPSCs), with the potential to form fresh myocardium and better safety than other stem cells, are widely used in the CVD therapy studies. Moreover, iPSC-derived cardiomyocytes (CMs), as a novel disease model, appear to play an important role in new drug screening, drug safety assessment, and pathological mechanisms of disease. Read More

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http://dx.doi.org/10.2174/1389450120666181211164147DOI Listing
December 2018
1 Read

Heat shock proteins (HSPs): A novel target for cancer metastasis prevention.

Curr Drug Targets 2018 Dec 10. Epub 2018 Dec 10.

Scientific Officer in charge, Cell and Tissue Culture Department, Micro labs, Bangalore. India.

Background: Heat shock proteins (HSPs) are predominant molecular chaperone which is actively involved in the protein folding; which is essential in protecting the structure and functioning of proteins during various stress conditions. Though HSPs have important physiological roles, they have been well known for their roles in various pathogenic conditions such as carcinogenesis; however, limited literature has consolidated its potential as an anti-metastatic drug target.

Objectives: The present review outlines the role of different HSPs on cancer progression and metastasis; possible role of HSP inhibitors as anti-neoplastic agents are also discussed. Read More

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http://dx.doi.org/10.2174/1389450120666181211111815DOI Listing
December 2018
4 Reads
3.112 Impact Factor

Understanding Membrane Protein Drug Targets in Computational Perspective.

Curr Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

School of Information Science and Technology, Northeast Normal University, Changchun. China.

Membrane proteins play a crucial physiological role in vivo and are the major category of drug targets for pharmaceuticals. The research on membrane protein is a significant part in drug discovery due to a membrane protein can be regarded as a vital hub while most drug effect by drug-target interaction and the biological process can be supposed as a cycled network. In this review, typical membrane protein targets are described, including GPCRs, transporters, ion channels. Read More

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http://dx.doi.org/10.2174/1389450120666181204164721DOI Listing
December 2018
20 Reads

Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.

Curr Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

Graduate Program in Cellular and Molecular Biology. The Pontifical Catholic University of Rio Grande do Sul (PUCRS). Av. Ipiranga, 6681 Porto Alegre/RS 90619-900 . Brazil.

Background: Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-cycle progression. The elucidation of the CDK2 structure paved the way to investigate the molecular basis for inhibition of this enzyme, with the coordinated efforts combining crystallography with functional studies.

Objective: Our goal here is to review recent functional and structural studies directed to understanding the role of CDK2 in cancer and senescence. Read More

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http://dx.doi.org/10.2174/1389450120666181204165344DOI Listing
December 2018
24 Reads

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets.

Curr Drug Targets 2018 12 4. Epub 2018 Dec 4.

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522. Australia.

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation system (PAS) is associated with a wide range of physiological and pathophysiological states involving fibrinolysis, inflammation and tissue remodeling. Various components of the PAS are implicated in the pathophysiology of RA. Read More

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http://dx.doi.org/10.2174/1389450120666181204164140DOI Listing
December 2018
2 Reads

Opportunities of bacterial cellulose to treat epithelial tissues.

Curr Drug Targets 2018 Nov 28. Epub 2018 Nov 28.

Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Friedrich Schiller University Jena, 07743 Jena. Germany.

In this mini review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are continuous cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids among other vital functions. Read More

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http://dx.doi.org/10.2174/1389450120666181129092144DOI Listing
November 2018
4 Reads

Saccharomyces cerevisiae (Baker's Yeast) as an Interfering RNA Expression and Delivery System.

Curr Drug Targets 2018 Nov 26. Epub 2018 Nov 26.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, South Bend, IN. United States.

The broad application of RNA interference for disease prevention is dependent upon production of dsRNA in an economically feasible, scalable, and sustainable fashion, as well as the identification of safe and effective methods for RNA delivery. Current research has sparked interest in the use of Saccharomyces cerevisiae for these applications. This review examines the potential for commercial development of yeast interfering RNA expression and delivery systems. Read More

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http://dx.doi.org/10.2174/1389450120666181126123538DOI Listing
November 2018
14 Reads

Potential therapeutic agents against Par-4 target for cancer treatment: where are we going?

Curr Drug Targets 2018 Nov 26. Epub 2018 Nov 26.

Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE. Brazil.

One of the greatest challenges of cancer therapeutics nowadays is to find selective targets successfully. Prostate apoptosis response-4 (Par-4) is a selective tumor suppressor protein with an interesting therapeutic potential due to its specificity on inducing apoptosis in cancer cells. Par-4 activity and levels can be downregulated in several tumors and cancer cell types, indicating poor prognosis and treatment resistance. Read More

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http://dx.doi.org/10.2174/1389450120666181126122440DOI Listing
November 2018
2 Reads

Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development.

Curr Drug Targets 2018 11 23. Epub 2018 Nov 23.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. China.

Hypoxia, which occurs in most cancer cases, disrupts the efficacy of anticarcinogens. Fortunately, hypoxia itself is a potential target for cancer treatment. Hypoxia-activated prodrugs (HAPs) can be selectively activated by reductase under hypoxia. Read More

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http://dx.doi.org/10.2174/1389450120666181123122406DOI Listing
November 2018
11 Reads

Functional diversity of quorum sensing receptors in pathogenic bacteria: Interspecies, intraspecies and interkingdom level.

Curr Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513. Korea.

Biofilm formation by pathogenic bacteria is considered as one of the most powerful mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed as a structural adherent over the surfaces of host, food and equipments etc. and are further functionally coordinated by certain chemicals produced by them. Read More

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http://dx.doi.org/10.2174/1389450120666181123123333DOI Listing
November 2018
10 Reads

Three-Dimensional Manufactured Supports for Breast Cancer Stem Cell Population Characterization.

Curr Drug Targets 2018 Nov 21. Epub 2018 Nov 21.

New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona. Spain.

Breast Cancer (BC) is the most common cancer among women as well as it is the second cause of female deaths. When the tumor is not correctly eradicated there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anti-cancer therapies being in part responsible of relapse tumor and metastasis. Read More

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http://dx.doi.org/10.2174/1389450120666181122113300DOI Listing
November 2018
7 Reads

In Silico design and synthesis of targeted curcumin derivatives as Xanthine Oxidase inhibitors.

Curr Drug Targets 2018 Nov 21. Epub 2018 Nov 21.

Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak. India.

Background: Curcumin is a well-known pharmacophore and some of its derivatives are shown to target xanthine oxidase (XO) to alleviate disorders caused by the excess production of uric acid.

Objective: Curcumin based derivatives were designed, synthesized and evaluated for their antioxidant and xanthine oxidase inhibitory potential.

Method: In this report, we designed and synthesized two series of curcumin derivatives modified by inserting pyrazole and pyrimidine ring to central keto group. Read More

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http://dx.doi.org/10.2174/1389450120666181122100511DOI Listing
November 2018
14 Reads

The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated Diseases.

Curr Drug Targets 2018 Nov 19. Epub 2018 Nov 19.

Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Haryana. India.

The receptor for advanced glycation end products (RAGE) is a multi-ligand pattern recognition receptor that is highly expressed in lung epithelial cells. It helps alveolar epithelial cells to maintain their morphology and specific architecture. However, in various pathophysiological conditions, pulmonary tissues express supraphysiological level of RAGE and its ligands including advanced glycation end products, high mobility group box 1 proteins and S100 proteins. Read More

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http://dx.doi.org/10.2174/1389450120666181120102159DOI Listing
November 2018
8 Reads

Aryl hydrocarbon receptor: its regulation and role in tumorigenesis.

Authors:
Xun Che Wei Dai

Curr Drug Targets 2018 Nov 8. Epub 2018 Nov 8.

Department of Environmental Medicine, New York University Langone Health, New York, New York 10010. United States.

AhR is an environmental response gene that mediates cellular responses to a variety of xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect of many xenobiotics in vivo. Read More

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http://dx.doi.org/10.2174/1389450120666181109092225DOI Listing
November 2018
14 Reads

Established and In-trail GPCR Families in Clinical Trials: A Review for Target Selection.

Curr Drug Targets 2018 Nov 5. Epub 2018 Nov 5.

Allied Health Sciences, Assam Down Town University, Panikhaiti, Guwahati 781026, Assam. India.

The key down player remains for drug industries is the selection of biological target currently attracting huge investments to validate them in patient subsets in order to study potential drugs. GPCRs are one such druggable target wherein non-olfactory GPCRs are encoded by 50% of the human genome-encoded which are therapeutically unexploited. The concept of ploypharmacology has become essential part of therapeutics for complex diseases like schizophrenia, cancer etc and considering the promiscuity and selectivity GPCRs could emerge as novel targets. Read More

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http://dx.doi.org/10.2174/1389450120666181105152439DOI Listing
November 2018
1 Read

Does Vitamin K Intake Influence High Phosphate Induced Vascular Pseudo-ossification: An Underappreciated Therapeutic Prospect in General Population?

Curr Drug Targets 2019 ;20(4):421-430

Basic Medical Science Cluster, Faculty of Medicine, Sungai Buloh Campus, 47000 Selangor; Universiti Teknologi MARA, Malaysia.

Increasing interest in vascular pseudo-ossification has alarmed the modern atherosclerotic society. High phosphate is one of the key factors in vascular pseudo ossification, also known as vascular calcification. The active process of deposition of the phosphate crystals in vascular tissues results in arterial stiffness. Read More

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http://dx.doi.org/10.2174/1389450119666181031124430DOI Listing
January 2019
1 Read

Essential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistance.

Curr Drug Targets 2018 Oct 31. Epub 2018 Oct 31.

Laboratory of Natural Product Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001. India.

Antimicrobial resistance (AMR) is an emerging problem in the world that has a significant impact on our society. AMR made conventional drugs futile against microorganisms and diseases untreatable. Plant-derived medicines are considered as safe alternatives to synthetic drugs. Read More

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http://dx.doi.org/10.2174/1389450119666181031122917DOI Listing
October 2018
3 Reads

Developing Practical Therapeutic Strategies that Target Protein SUMOylation.

Curr Drug Targets 2018 Oct 26. Epub 2018 Oct 26.

Department of Chemistry and Biochemistry, University of Notre Dame Notre Dame, Indiana 46556. United States.

Post-translational modification by small ubiquitin-like modifier (SUMO) has emerged as a global mechanism for the control and integration of a wide variety of biological processes through the regulation of protein activity, stability and intracellular localization. As SUMOylation is examined in greater detail, it has become clear that the process is at the root of several pathologies including heart, endocrine, and inflammatory disease, and various types of cancer. Moreover, it is certain that perturbation of this process, either globally or of a specific protein, accounts for many instances of congenital birth defects. Read More

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http://dx.doi.org/10.2174/1389450119666181026151802DOI Listing
October 2018
2 Reads

CDK9 as an Appealing Target for Therapeutic Interventions.

Curr Drug Targets 2019 ;20(4):453-464

Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. Read More

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http://dx.doi.org/10.2174/1389450119666181026152221DOI Listing
January 2019
10 Reads

Snake Venom Disintegrins: An Overview of their Interaction with Integrins.

Curr Drug Targets 2019 ;20(4):465-477

Department of Chemistry, Biochemistry Laboratory, Federal University of Lavras (UFLA), Lavras, Minas Gerais, 37200-000, Brazil.

Disintegrins are non-enzymatic proteins that interfere on cell-cell interactions and signal transduction, contributing to the toxicity of snake venoms and play an essential role in envenomations. Most of their pharmacological and toxic effects are the result of the interaction of these molecules with cell surface ligands, which has been widely described and studied. These proteins may act on platelets, leading to hemorrhage, and may also induce apoptosis and cytotoxicity, which highlights a high pharmacological potential for the development of thrombolytic and antitumor agents. Read More

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http://dx.doi.org/10.2174/1389450119666181022154737DOI Listing
January 2019
22 Reads

Prediction of Ion Channels and Their Types from Protein Sequences: Comprehensive Review and Comparative Assessment" as an original article to Current Drug Targets.

Curr Drug Targets 2018 Oct 22. Epub 2018 Oct 22.

Department of Computer Science, Virginia Commonwealth University, Richmond. United States.

Background:Ion channels are a large and growing protein family. Many of them are associated with diseases and consequently they are targets for over 700 drugs. Discovery of new ion channels is facilitated with computational methods that predict ion channels and their types from protein sequences. Read More

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http://dx.doi.org/10.2174/1389450119666181022153942DOI Listing
October 2018
1 Read

Molecular Docking: Challenges, Advances and Its Use in Drug Discovery Perspective.

Curr Drug Targets 2018 Oct 22. Epub 2018 Oct 22.

Natural Products Chemistry Group, CSIR North East Institute of Science & Technology, Jorhat-785006, Assam. India.

Molecular docking is a process through which small molecules are docked into the macromolecular structures for scoring its complementary values at the binding sites. It is a vibrant research area with dynamic utility in structure based drug-designing, lead optimization, biochemical pathway and for drug designing being the most attractive tools. Two pillars for a successful docking experiment are correct pose and affinity prediction. Read More

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http://dx.doi.org/10.2174/1389450119666181022153016DOI Listing
October 2018
13 Reads

Estrogen receptor alpha and its ubiquitination in breast cancer cells.

Curr Drug Targets 2018 Oct 15. Epub 2018 Oct 15.

Instituto de Investigaciones Biomédicas. Universidad Nacional Autónoma de México. Mexico City, 04510. Mexico.

More than 70% of all breast cancer cases are estrogen receptor alpha-positive (ERα). ERα is a member of the nuclear receptor family, and its activity is implicated in the gene transcription linked to the proliferation of breast cancer cells, as well as in extranuclear signaling pathways related to the development of resistance to endocrine therapy. Several protein-protein interactions and post-translational modifications of ERα represent critical mechanisms that modulate its activity. Read More

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http://www.eurekaselect.com/166225/article
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http://dx.doi.org/10.2174/1389450119666181015114041DOI Listing
October 2018
15 Reads

Helenalin - A Sesquiterpene Lactone with Multidirectional Activity.

Curr Drug Targets 2019 ;20(4):444-452

Department of Biomolecular Chemistry, Medical University of Lodz, Lodz, Poland.

Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including antiinflammatory, anti-bacterial and anti-cancer properties. The best-known sesquiterpene lactones which are already used as drugs or are used in clinical trials are artemisinin, thapsigargin and parthenolide. Read More

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http://dx.doi.org/10.2174/1389450119666181012125230DOI Listing
January 2019
10 Reads

A survey for predicting enzyme family classes using machine learning methods.

Curr Drug Targets 2018 Oct 2. Epub 2018 Oct 2.

Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054. China.

Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzymes have different biological functions and acting objects. Read More

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http://dx.doi.org/10.2174/1389450119666181002143355DOI Listing
October 2018
16 Reads

Preparation and application of glyconanoparticles.

Authors:
Gangliang Huang

Curr Drug Targets 2018 Sep 26. Epub 2018 Sep 26.

Active Carbohydrate Research Institute, Chongqing Normal University, Chongqing, 401331. China.

The interaction between a sugar molecule and a target is relatively weak. By simultaneously linking multiple sugar molecules to one nanoparticle for forming the glyconanoparticle, the targeting can be greatly improved. This is due to the existence of multivalent interactions between the glyconanoparticle and the target. Read More

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http://dx.doi.org/10.2174/1389450119666180926111133DOI Listing
September 2018
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Towards Computational Models of Identifying Protein Ubiquitination Sites.

Curr Drug Targets 2018 Sep 24. Epub 2018 Sep 24.

College of Science, Dalian Maritime University, Dalian 116026. China.

Ubiquitination is an important post-translational modification in regulating protein functions, which provides a key insight to discover the causes associated with cancer, cardiovascular and other diseases. Recent attempts have been made for capturing potential ubiquitination sites with the aid of chemo-proteomic approaches and computational methods. Experimental identification of ubiquitination sites is especially vulnerable to the temporality and reversibility of ubiquitination processes, which is also costly and time-consuming. Read More

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http://dx.doi.org/10.2174/1389450119666180924150202DOI Listing
September 2018
2 Reads

Safety and Efficacy of Rifaximin in Prophylaxis of Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-analysis.

Curr Drug Targets 2019 ;20(4):380-387

Department of Tropical Medicine & Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt.

Aim: The role of rifaximin in the prevention of Spontaneous Bacterial Peritonitis (SBP) is not well studied. The aim of this meta-analysis was to evaluate the role of rifaximin in the prevention of SBP.

Methods: A computerized literature search for relevant clinical trials was conducted during August 2017. Read More

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http://dx.doi.org/10.2174/1389450119666180924145156DOI Listing
January 2019
7 Reads
3.021 Impact Factor

The Value of Biomarkers in Optimizing the Use of Immuno-oncologic Therapy.

Curr Drug Targets 2019 ;20(1):81-86

Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre, Toronto, ON, Canada.

The development of therapies that restore or activate the host immune response - the socalled "immuno-oncologic" therapy - has improved the survival of some cancer patients harboring specific tumor types. These drugs, however, are very expensive which has greatly limited their use and consequently reduced the number of patients who could likely benefit. Not to mention, the proportion of patients who display a clinical benefit from therapy is limited. Read More

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http://dx.doi.org/10.2174/1389450119666180911093143DOI Listing
January 2019
1 Read

The Therapeutic and Psychosocial Interaction in Enhancing Drug Targets.

Curr Drug Targets 2018 ;19(12):1351

Faculty of Medicine, University of Malaya 50603 Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.2174/138945011912180723102630DOI Listing
January 2018
2 Reads

Problems and Perspectives of Abdominal Aortic Aneurysm Research.

Authors:
Hiroki Tanaka

Curr Drug Targets 2018 ;19(11):1227

Department of Medical Physiology Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.2174/138945011911180720122330DOI Listing
January 2018
1 Read

Stem Cells and Tissue Engineering in Medical Practice: Ethical and Regulatory Policies.

Authors:
Rakesh Sharma

Curr Drug Targets 2019 ;20(4):388-398

Iinovations and Solutions Inc. FSU Tallahassee AMET University Global, United States.

Stem Cell Research and Tissue Engineering, in present time, have emerged as a legalized and regulated stem cell treatment option globally, but scientifically, their success is unestablished. Novel stem cell-based therapies have evolved as innovative and routine clinical solutions by commercial companies and hospitals across the world. Such rampant spread of stem cell clinics throughout UK, US, Europe and Asia reflect the public encouragement of benefits to incurable diseases. Read More

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http://dx.doi.org/10.2174/1389450119666180831095830DOI Listing
January 2019
13 Reads

Do the Natural Chemical Compounds Interact with the Same Targets of Current Pharmacotherapy for Weight Management?-A Review.

Curr Drug Targets 2019 ;20(4):399-411

Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.

Background: Obesity has become a worldwide health concern. Pharmacotherapies are now being introduced because lifestyle modifications alone are insufficient for weight management. The treatment outcomes of current approved anti-obesity agents are not satisfying due to drug-related intolerances. Read More

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http://dx.doi.org/10.2174/1389450119666180830125958DOI Listing
January 2019
1 Read

Melatonin as Potential Targets for Delaying Ovarian Aging.

Curr Drug Targets 2019 ;20(1):16-28

Chinese University of Hong Kong - Shandong University Joint Laboratory for Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, SAR, Hong Kong.

In previous studies, oxidative stress damage has been solely considered to be the mechanism of ovarian aging, and several antioxidants have been used to delay ovarian aging. But recently, more reports have found that endoplasmic reticulum stress, autophagy, sirtuins, mitochondrial dysfunction, telomeres, gene mutation, premature ovarian failure, and polycystic ovary syndrome are all closely related to ovarian aging, and these factors all interact with oxidative stress. These novel insights on ovarian aging are summarized in this review. Read More

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http://dx.doi.org/10.2174/1389450119666180828144843DOI Listing
January 2019
22 Reads