590 results match your criteria Current Drug Safety[Journal]


A "crazy paving" pattern on CT scan in a patient treated with Pembrolizumab.

Curr Drug Saf 2019 Mar 11. Epub 2019 Mar 11.

Istituto Figlie di San Camillo. Dept of Internal Medicine. Cremona. Italy.

Background: Programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have shown great promise in clinical practice and have been incorporated into standard management of NSCLC. Pneumonitis is a serious autoimmune toxicity associated with the use of anti-PD-1/PD-L1 antibodies, resulting in significant morbidity and mortality.

Methods: We described the case of a 73-year-old woman with no history of smoking developing exertional dyspnea four months after taking Pembrolizumab. Read More

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http://www.eurekaselect.com/170646/article
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http://dx.doi.org/10.2174/1574886314666190312115648DOI Listing
March 2019
8 Reads

Adverse drug reactions of anti-epileptic drugs in children with epilepsy: a cross-sectional study Running Title: Adverse drug reactions to Anti-epileptic drugs.

Curr Drug Saf 2019 Mar 10. Epub 2019 Mar 10.

Department of Pediatrics, School of Medical Sciences &Research, Sharda University, Greater Noida, Uttar Pradesh 201310. India.

Background: Adverse drug reactions (ADRs) due to antiepileptic drugs (AEDs) in children contribute to poorer patient outcomes. However, we lack reliable data on the burden of such ADRs.

Objectives: Thus, the aim of the present study was to determine the incidence and patterns of ADRs of antiepileptic drugs in children aged 2-17 years presenting to a tertiary care teaching hospital. Read More

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http://dx.doi.org/10.2174/1574886314666190311112710DOI Listing
March 2019
1 Read

Significant Weight Loss In A Patient Taking Olmesartan: An Unusual Case Report.

Curr Drug Saf 2019 Mar 7. Epub 2019 Mar 7.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina. Greece.

Objective: Olmesartan-induced enteropathy consists a syndrome that mimics celiac disease both clinically and histologically. Cases of this entity have sporadically been reported since 2012 and are usually characterized by severe diarrhea and malabsorption, followed by significant weight loss.

Case Report: Herein, we report an uncommon case of this syndrome, where weight loss preceded several months the onset of gastrointestinal symptoms. Read More

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http://dx.doi.org/10.2174/1574886314666190307142111DOI Listing
March 2019
8 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome associated with Ethambutol use: A Case Report.

Curr Drug Saf 2019 Mar 7. Epub 2019 Mar 7.

Department of pharmacology Lady Hardinge Medical College and associated hospitals. India.

Among the first line anti-tubercular drugs (ATDs), ethambutol has been rarely associated to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. A 34-year-old woman presented in out-patient department of Dermatology with fever, skin eruptions, eosinophilia, hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs. The patient recovered completely after stopping ethambutol and administration of topical and systemic corticosteroids. Read More

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http://dx.doi.org/10.2174/1574886314666190307150757DOI Listing
March 2019
2 Reads

Postoperative clinical monitoring after morphine administration: a retrospective multicenter practice survey.

Curr Drug Saf 2019 Mar 5. Epub 2019 Mar 5.

Department of Anesthesiology and Intensive Care, University Hospital of Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy cedex. France.

Background: The objective of this survey was to describe the clinical monitoring practically used after intravenous, subcutaneous or neuraxial (epidural or intrathecal) administration of morphine.

Methods: This was a descriptive, retrospective, multicenter (10 hospitals) survey based on the medical charts' analysis which evaluated the postoperative clinical monitoring after morphine administration.

Results: Morphine was delivered intravenously (69%), intrathecally (19%), epidurally (10%) and/or subcutaneously (12%). Read More

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http://www.eurekaselect.com/170472/article
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http://dx.doi.org/10.2174/1574886314666190306110434DOI Listing
March 2019
5 Reads

Non-uremic calciphylaxis: a rare and late adverse reaction of warfarin.

Curr Drug Saf 2019 Mar 3. Epub 2019 Mar 3.

GCS Medical College, Ahmedabad. India.

Calciphylaxis is a complex dermatological lesion of micro vascular calcification that is typically presented as panniculitis with gangrenous painful lesions having uremic and non-uremic causes. We present a case of a 48-year male with a history of paroxysmal atrial fibrillation and hypertension taking amlodipine 5 mg and warfarin 5 mg daily for the last 26 month. The patient had a 6-month history of painful swelling followed by necrotic skin ulcer over the right leg. Read More

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http://dx.doi.org/10.2174/1574886314666190304094407DOI Listing
March 2019
31 Reads

Positive and negative effects of antipsychotic medication: an international online survey of 832 recipients.

Curr Drug Saf 2019 Mar 1. Epub 2019 Mar 1.

Department of Psychological Sciences, Swinburne University of Technology, Melbourne. Australia.

Background: Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first hand experience of recipients.

Objectives: To ascertain the experiences and opinions of users of an international sample of antipsychotic drugs regarding positive and negative effects.

Method: An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries - predominantly USA, UK and Australia. Read More

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http://dx.doi.org/10.2174/1574886314666190301152734DOI Listing
March 2019
3 Reads

Treatment with paracetamol is not associated with increased airway sensitivity and risk of asthma in rats.

Curr Drug Saf 2019 02 22. Epub 2019 Feb 22.

Faculty of Pharmacy, Federal University of Goias, Avenida Universitária s/n, 74605-220, Goiânia, GO, Brazil.

Background Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate. Read More

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http://dx.doi.org/10.2174/1574886314666190222194841DOI Listing
February 2019
1 Read

Idiosyncratic drug-induced acute liver failure: A challenging and distressing scenario

Curr Drug Saf 2019 02 14. Epub 2019 Feb 14.

University of Rosario School of Medicine, Rosario, Argentina.

Idiosyncratic drug induced liver injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of acute liver failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Thus, careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Read More

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http://dx.doi.org/10.2174/1574886314666190215115434DOI Listing
February 2019
1 Read

Citalopram-Associated Alopecia: A Case Report and Brief Literature Review.

Curr Drug Saf 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, Western Michigan University, Homer Stryker M.D. School of Medicine, Kalamazoo, MI . United States.

Background: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer improved side effect profile compared to older treatments, which improve patient adherence and quality of life.

Case Report: Here we discuss a case of an uncommon, but distressing side effect of citalopram. Read More

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http://dx.doi.org/10.2174/1574886314666190215115857DOI Listing
February 2019
4 Reads

Cerebellar Dysfunction in an Elderly Male After a Brief Course of Metronidazole

Curr Drug Saf 2019 02 6. Epub 2019 Feb 6.

Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP. India.

Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances in rare circumstances. Here, we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy. Read More

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http://dx.doi.org/10.2174/1574886314666190206154735DOI Listing
February 2019
2 Reads

New indices for ethnotoxicological assessment of medicinal plants: example of Tafilalet region, Morocco.

Curr Drug Saf 2019 Feb 6. Epub 2019 Feb 6.

Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000. Morocco.

Background: several botanical species are poisonous and are used for medicinal purposes in traditional medicine. In fact, a relationship between toxicity and phytotherapeutic potent of medicinal plants exists.

Introduction: Until now, there is no ethnopharmacological indices evaluating mathematically the toxic property of any medicinal plant used traditionally. Read More

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http://dx.doi.org/10.2174/1574886314666190206184436DOI Listing
February 2019
1 Read

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus.

Curr Drug Saf 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Lucknow (UP). India.

Background: Recently, Food and Drug Administration (FDA) has approved sodium/glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT 2 inhibitors. Read More

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http://dx.doi.org/10.2174/1574886314666190206164647DOI Listing
February 2019
8 Reads

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by imatinib.

Curr Drug Saf 2019 Jan 30. Epub 2019 Jan 30.

National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis.. Tunisia.

Imatinib is the treatment of choice in patients with locally advanced or metastatic gastrointestinal stromal tumours (GIST). Clinical tolerance of imatinib is excellent except the common adverse drug reaction (ADR). Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia, and elevated liver function tests. Read More

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http://www.eurekaselect.com/169478/article
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http://dx.doi.org/10.2174/1574886314666190130150243DOI Listing
January 2019
11 Reads

Preface.

Authors:
Seetal Dodd

Curr Drug Saf 2019 ;14(1)

University of Melbourne Geelong, 3220 Melbourne, Australia.

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http://dx.doi.org/10.2174/157488631401190117163248DOI Listing
January 2019

Depression, Antidepressants and Hypertensive Disorders of Pregnancy: A Systematic Review.

Curr Drug Saf 2019 Jan 21. Epub 2019 Jan 21.

Department of Psychiatry and Obstetrics and Gynecology Western University, Ontario. Canada.

Background: Hypertensive disorders of pregnancy including gestational hypertension, preeclampsia and eclampsia are conditions that cause significant perinatal and maternal morbidity and mortality.

Objective: This is a systematic review of the current evidence examining the relationship between both depression and antidepressants on pregnancy-related hypertensive conditions.

Method: In accordance with Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) protocol, six databases were searched for articles published between January 1990 and December 2017 (PubMed, Embase, PsycINFO, Cochrane Database of Systematic Reviews, MEDLINE and ClinicalTrials. Read More

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http://dx.doi.org/10.2174/1574886314666190121144711DOI Listing
January 2019
17 Reads

Adverse drug reactions to radiographic contrast media in a teaching hospital in North India: An observational study.

Curr Drug Saf 2019 Jan 21. Epub 2019 Jan 21.

Hamdard Institute of Medical Sciences and Research Jamia Hamdard New Delhi-62. India.

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Read More

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http://dx.doi.org/10.2174/1574886314666190122095702DOI Listing
January 2019

A Novel Desensitization Protocol for Infliximab hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis.

Curr Drug Saf 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Chennai. India.

Background: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients. Read More

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http://dx.doi.org/10.2174/1574886314666190119115632DOI Listing
January 2019
12 Reads

Double infection in a patient with psoriatic arthritis under TNF-alpha blockers therapy: a case report.

Curr Drug Saf 2019 Jan 14. Epub 2019 Jan 14.

Department of Health Science, University of Catanzaro, and Clinical Pharmacology and Pharmacovigilance Operative Unit MaterDomini Hospital Catanzaro. Italy.

Background: Either direct or indirect tumor necrosis factor (TNF)-alpha blockers, are usually used to treat psoriatic arthritis (PA), but their use can increase susceptibility to infectious diseases.

Case Presentation: We report a rare case of double skin-knee wound and lung non-tubercular infection in a patient with PA under TNF-alpha blockers therapy. About 1 year after the beginning of adalimumab, a 48-year-old smoker suffering of PA was hospitalized for skin-knee wound. Read More

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http://dx.doi.org/10.2174/1574886314666190114124625DOI Listing
January 2019
10 Reads

Evaluation of Hospital Discharge Prescriptions in the Elderly and Younger Adults Using the Medication Regimen Complexity Index.

Curr Drug Saf 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Karnataka. India.

Background: Advances in the clinical management of diseases have been accompanied by increasing complexity of treatment regimens. The complexity of medication regimen is of concern for patients as well as doctors as it may adversely affect patient compliance and treatment outcomes. It may result in medication errors, increased utilization of health resources owing to a reduction in treatment effectiveness, and increased risk of therapeutic failure. Read More

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http://dx.doi.org/10.2174/1574886314666181207105118DOI Listing
December 2018
1 Read

Glecaprevir/Pibrentasvir Induced Cholestatic Jaundice in a HCV Patient with Renal Failure. A Case Presentation.

Curr Drug Saf 2019 ;14(1):67-71

Department of Health Sciences, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, University of Catanzaro, Catanzaro, Italy.

Background: Direct-acting Antivirals (DAA) are currently used in the treatment of chronic HCV infection. In patients with renal failure Glecaprevir/Pibrentasvir (genotype 1-6) is recommended for its safety and efficacy.

Case Presentation: Although these pharmacological characteristics, an adverse drug reaction (ADR) has been reported during Glecaprevir/Pibrentasvir treatment, such as the development of cholestatic jaundice in an elderly patient with chronic HCV (genotype 2) infection. Read More

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http://www.eurekaselect.com/167424/article
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http://dx.doi.org/10.2174/1574886313666181116100452DOI Listing
January 2019
38 Reads

Report of Adverse Events in Colombia: A Successful Case.

Curr Drug Saf 2019 ;14(1):53-56

National Food and Drug Surveillance Institute (INVIMA), Carrera 10 # 64, 28 Bogota, Colombia.

Background: The Colombian National Food and Drug Surveillance Institute (INVIMA) is responsible for monitoring the safety and efficacy of medicines circulating the Colombian market.

Discussion: This article summarizes the three key strategies the institution has implemented to strengthen the National Pharmacovigilance Program: improving the interaction and working relationship with regional health authorities, expanding the National Pharmacovigilance Network and implementing the electronic submission of adverse events.

Conclusion: The number of adverse events reported in Colombia increased from 5,447 in 2013 to 95,658 in 2017, reaching a population-based reporting ratio within international standards (563 in 2016). Read More

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http://www.eurekaselect.com/167216/article
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http://dx.doi.org/10.2174/1574886313666181109150648DOI Listing
January 2019
24 Reads

Delayed Hemolytic Anemia after Treatment with Artesunate: Case Report and Literature Review.

Curr Drug Saf 2019 ;14(1):60-66

Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Background: In recent years, few cases of post-artemisinin delayed hemolysis have been reported.

Objective: All cases of post-artemisinin delayed hemolysis were reported from non-middle east areas. No case of post-artemisinin delayed hemolysis has yet been reported from this region. Read More

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http://www.eurekaselect.com/167215/article
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http://dx.doi.org/10.2174/1574886313666181109150157DOI Listing
January 2019
22 Reads

Cardiotoxicity Associated with Midazolam in a Patient with Diphtheria.

Curr Drug Saf 2019 ;14(1):57-59

Pediatrics Department, Government Medical College, Sir T. General Hospital, Bhavnagar, Gujarat, India.

Background: Adverse cardiorespiratory events are associated with midazolam continuous IV infusion, used for sedation.

History: Here we are reporting a case of 5 year old male child suffering from diphtheria induced airway obstruction, and myocarditis, who received midazolam in the form of IV infusion for sedation while undergoing mechanical ventilation for respiratory failure. Adverse Event: Six hours after starting midazolam infusion he started developing pulsus bigeminus and bradycardia and eventual death after two hours. Read More

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http://dx.doi.org/10.2174/1574886313666181105122154DOI Listing
January 2019
4 Reads

Phenytoin Induced Chorea: A Rare Adverse Effect of the Drug.

Curr Drug Saf 2019 ;14(1):51-52

B. J. Medical College, Ahmedabad, India.

Background: Dyskinetic neurological diseases are common presentations of adverse reaction to many therapeutic agents. Phenytoin, a widely used age-old antiepileptic drug has been reported to cause dyskinesias, a rare Adverse Drug Reaction (ADR) in adults with toxic therapeutic serum level. When the drug is used in combination with other drugs which augments free drug level of phenytoin or in patients of organic brain lesion, this side effect is very occasionally reported with even normal therapeutic drug level. Read More

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http://dx.doi.org/10.2174/1574886313666181031161215DOI Listing
January 2019
4 Reads

Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients.

Curr Drug Saf 2019 ;14(1):27-30

Family and Community Medicine Department, Unaizah College of Medicine and Medical Sciences, Qassim University, Qassim, Saudi Arabia.

Background: Cardioselective beta-blockers may affect glucose or lipid profiles.

Objective: We sought to compare the effects of two beta-blockers, metoprolol and bisoprolol, as the most commonly used drugs in cardiology, on glucose and lipid profiles in patients with cardiovascular diseases.

Methods: We conducted a retrospective cross-sectional matched study at Prince Sultan Cardiac Center in Burydah in August 2017. Read More

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http://dx.doi.org/10.2174/1574886313666181029101247DOI Listing
January 2019
13 Reads

Biperiden-Induced Delirium In A Five-Years Old Child.

Curr Drug Saf 2019 ;14(1):48-50

Department of Psychiatry, Ergani State Hospital, Diyarbakır, Turkey.

Objective: Extrapyramidal adverse effects of antipsychotic drugs are more reported in children. Biperiden is an anticholinergic agent to treat the adverse effects of antipsychotic drugs. The drug has the potential to induce delirium at toxic doses. Read More

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http://dx.doi.org/10.2174/1574886313666181029101830DOI Listing
January 2019
12 Reads

Novel Adverse Events of Iloperidone: A Disproportionality Analysis in US Food and Drug Administration Adverse Event Reporting System (FAERS) Database.

Curr Drug Saf 2019 ;14(1):21-26

Department of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, India.

Background: The signal is defined as "reported information on a possible causal relationship between an adverse event and a drug, of which the relationship is unknown or incompletely documented previously".

Objective: To detect novel adverse events of iloperidone by disproportionality analysis in FDA database of Adverse Event Reporting System (FAERS) using Data Mining Algorithms (DMAs).

Methodology: The US FAERS database consists of 1028 iloperidone associated Drug Event Combinations (DECs) which were reported from 2010 Q1 to 2016 Q3. Read More

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http://dx.doi.org/10.2174/1574886313666181026100000DOI Listing
January 2019
2 Reads

Plantar Psoriasis Associated with Olmesartan.

Curr Drug Saf 2019 ;14(1):77-79

National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.

Background: Psoriasis is a chronic inflammatory skin disorder that may be initiated or exacerbated by some drug intakes. Some of the most common medications known to trigger or worsen existing psoriasis include lithium, gold salts, beta blockers and antimalarials.

Conclusion: We report an exceptional case of plantar psoriasis in a woman who was treated by olmesartan for 3 years. Read More

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http://dx.doi.org/10.2174/1574886313666181017120629DOI Listing
January 2019
2 Reads

Complications of Immunoglobulin Therapy and Implications for Treatment of Inflammatory Neuropathy: A Review.

Curr Drug Saf 2019 ;14(1):3-13

Department of Neurophysiology, Queen Elizabeth Hospital, University Hospital of Birmingham, Birmingham, United Kingdom.

Background: Intravenous Immunoglobulin (IVIg) forms a cornerstone of effective treatment for acute and chronic inflammatory neuropathies, with a class I evidence base in Guillain-Barré Syndrome (GBS), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). It is generally considered to be a safe therapy however there are several recognised complications which are reviewed in this article.

Discussion And Conclusion: Most adverse events are immediate and mild such as headache, fever and nausea although more serious immediate reactions such as anaphylaxis may rarely occur. Read More

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http://dx.doi.org/10.2174/1574886313666181017121139DOI Listing
January 2019
4 Reads

Safety of Vinflunine in Patients with Advanced Urothelial Carcinoma Refractory to Platinum-based Chemotherapy: A Prospective Pilot Study.

Curr Drug Saf 2019 ;14(1):31-36

Clinical Oncology Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.

Background: Several single chemotherapeutic agents have been evaluated as the second-line treatment of advanced urothelial carcinoma. Despite encouraging efficacy outcomes, toxicity has often led to dose modifications or discontinuation. We aimed to assess the safety of vinflunine in a particular population of advanced transitional cell carcinoma of urothelium (TCCU), that were exposed to the previous toxicity of chemotherapy. Read More

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http://dx.doi.org/10.2174/1574886313666181001120752DOI Listing
January 2019
7 Reads

Taxane Induced Cystoid Macular Edema: Case Report and Integrated Pathogenic Theory.

Curr Drug Saf 2019 ;14(1):43-47

University of Patras, Medical School, University Eye Clinic, Rion University Hospital, Patras, Greece.

Purpose: To report a case of a 73-year-old man who presented with decreased visual acuity due to bilateral macular edema after paclitaxel administration for prostate cancer.

Methods: The ophthalmic evaluation consisted of medical and ocular history, Best Corrected Visual Acuity, slit-lamp biomicroscopy and Spectral-domain optical coherence tomography / Fluorescein Angiography.

Results: Optical Coherence Tomography and Fluorescein Angiography revealed silent cystoid macular edema. Read More

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http://dx.doi.org/10.2174/1574886313666180828163016DOI Listing
January 2019
15 Reads

Dabigatran Reversal with Idarucizumab in an Emergency Lumbar Puncture: A Case Report.

Curr Drug Saf 2019 ;14(1):40-42

Emergency Department Stroke Unit, Policlinico Umberto I Hospital in Rome, "Sapienza University of Rome", Rome, Italy.

Introduction: The widespread use of direct oral anticoagulants (DOACs) has been increasing the conditions in which emergency physicians are forced to rapidly reverse anticoagulation in case of life-threatening bleeding or need of urgent surgery or invasive procedures. The recent approval of Idarucizumab, a humanized monoclonal antibody fragment (Fab), offered the opportunity to rapidly and safely neutralize the anticoagulant effect of Dabigatran. However, real-world experience of its effective use in different emergency setting is now required. Read More

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http://dx.doi.org/10.2174/1574886313666180816125234DOI Listing
January 2019
2 Reads

Safety of a Clozapine Trial Following Quetiapine-Induced Leukopenia: A Case Report.

Curr Drug Saf 2019 ;14(1):80-83

Saudi Commission for Health Specialties, Psychiatry Speciality, Riyadh, Saudi Arabia.

Background: The clozapine-derivative quetiapine has been shown in some cases to cause leukopenia and neutropenia.

Case Presentation: We reported on a case of a young female diagnosed with treatment-resistant schizophrenia. After failed trials of three antipsychotic medications and despite a history of quetiapineinduced leukopenia, clozapine treatment was introduced due to the severity of the patient's symptoms, the limited effective treatment options, and a lack of guidelines on this issue. Read More

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http://dx.doi.org/10.2174/1574886313666180807094654DOI Listing
January 2019
4 Reads

Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report.

Curr Drug Saf 2019 ;14(1):72-76

Department of Microbiology, Government Medical College, Amritsar 110002, India.

Background: Fixed drug eruption is a clinical entity occurring at the same site each time the drug is administered. They are usually found on lips, genitalia, abdomen, and legs but can occur at any location. The eruptions usually occur within hours of administration of the drug and resolves spontaneously. Read More

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http://dx.doi.org/10.2174/1574886313666180807095559DOI Listing
January 2019
12 Reads

Dapsone Hypersensitivity Syndrome (DHS): A Detrimental Effect of Dapsone? A Case Report.

Curr Drug Saf 2019 ;14(1):37-39

Department of Pharmacology, PSG Institute of Medicl Sciences and Research, Coimbatore, Tamilnadu, India.

Background: Dapsone is a sulfone derived drug used in the treatment of leprosy and several chronic inflammatory dermatological diseases. Dapsone Hypersensitivity Syndrome (DHS) is characterized by fever, hepatitis, generalized exfoliative dermatitis and lymphadenopathy. It is rare and potentially fatal. Read More

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http://dx.doi.org/10.2174/1574886313666180731123232DOI Listing
January 2019
26 Reads

Cutaneous Adverse Events of Immune Checkpoint Inhibitors: A Summarized Overview.

Curr Drug Saf 2019 ;14(1):14-20

Dermatology Department, University General Hospital of Patras, Patras, Greece.

Background: The introduction of Immune Checkpoint Inhibitors in the recent years has resulted in high response rates and extended survival in patients with metastatic/advanced malignancies. Their mechanism of action is the indirect activation of cytotoxic T-cells through the blockade of inhibitory receptors of immunomodulatory pathways, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1) and its ligand (PD-L1). Despite their impressive therapeutic results, they can also induce immune-related toxicity, affecting various organs, including the skin. Read More

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http://dx.doi.org/10.2174/1574886313666180730114309DOI Listing
January 2019
46 Reads

Non-pigmenting Fixed Drug Eruption: An Unusual Adverse Reaction to Aceclofenac.

Curr Drug Saf 2018 ;13(3):224-225

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, GE Rd, Tatibandh, Raipur, Chhattisgarh, India.

Background: Aceclofenac is a phenylacetic acid derivative belongs to the group of nonsteroidal anti-inflammatory drug. It is commonly used in the treatment of pain and various inflammatory disorders. It is well tolerated, with most adverse events being minor and reversible and affecting mainly the GI system. Read More

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http://dx.doi.org/10.2174/1574886313666180726104812DOI Listing
January 2019
4 Reads

A Case of Severe Transaminase Elevation Following a Single Ustekinumab Dose with Remission After Drug Withdrawal.

Curr Drug Saf 2018 ;13(3):221-223

Section of Gastroenterology, Department of Emergency and Organ Transplantation, AOU Policlinico, University of Bari, Bari, Italy.

Background: Ustekinumab is a fully human monoclonal antibody which binds Interleukin (IL)-12/23. It is indicated for the treatment of moderate-severe psoriasis and active psoriatic arthritis. Few data are available about the possibility of an interaction between ustekinumab and the liver. Read More

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http://www.eurekaselect.com/163925/article
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http://dx.doi.org/10.2174/1574886313666180719165212DOI Listing
January 2019
10 Reads

Study of Adverse Drug Effects of Direct-Acting Antivirals for Chronic HCV Infection at Fayoum Governorate, Egypt - A Pharmacovigilance Study.

Curr Drug Saf 2018 ;13(3):187-195

Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Background: Different combinations of Direct Antiviral Agents (DAAs) have been used against different Hepatitis C Virus (HCV) genotypes and in different types of patients. Despite being effective and characterized by a very low rate of adverse effects in clinical trials, few data are available on adverse events in real life studies.

Objectives: The aim of this study was to identify the incidence and pattern of Adverse Drug Reactions (ADRs) caused by DAAs; daclatasvir and sofosbuvir and their combination with ribavirin and to assess the causality and the severity of the reported ADRs. Read More

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http://dx.doi.org/10.2174/1574886313666180716111529DOI Listing
January 2019
12 Reads

Off-Label Use of Drugs and Adverse Drug Reactions in Pediatric Units: A Prospective, Multicenter Study.

Curr Drug Saf 2018 ;13(3):200-207

Regional Pharmacovigilance Centre of Catania, Unit of Pharmacology - A.O.U. Policlinico - Vittorio Emanuele, Catania, Italy.

Background: Given the growing use of off-label in pediatric practice, there is a growing interest on pharmacovigilance programs monitoring the occurrence of adverse drug reactions related to off-label drug prescription in childhood.

Patients And Methods: The results of a one-year program of pharmacovigilance issued in the Sicilian Region, Italy, are herein presented. The study involved 6 pediatric and neonatal centres and prospectively reviewed the prescriptions of 5,060 patients, who were stratified for age (newborn, infant, children, adolescents). Read More

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http://www.eurekaselect.com/163095/article
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http://dx.doi.org/10.2174/1574886313666180619120406DOI Listing
January 2019
19 Reads

Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification.

Curr Drug Saf 2018 ;13(3):208-210

Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.

Objective: We present an interesting case of accidental overdose of latanoprost eye drops.

Case Report: A 71-year-old patient underwent an uncomplicated cataract surgery in his right eye. During the first postsurgical week he mistakenly used latanoprost eye drops six times daily instead of the prescribed tobramycin/dexamethasone eye drops. Read More

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http://dx.doi.org/10.2174/1574886313666180619163845DOI Listing
January 2019
2 Reads

Denosumab-induced Normocalcemic Hyperparathyroidism in a Woman with Postmenopausal Osteoporosis and Normal Renal Function.

Curr Drug Saf 2018 ;13(3):214-216

Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.

Background: Elevations in serum Parathyroid Hormone (PTH) levels after denosumab administration have been described in medical literature among patients with renal impairment or intestinal malabsortion syndromes.

Objective: To present a case of denosumab-induced normocalcemic hyperparathyroidism in a woman with postmenopausal osteoporosis without renal impairment or malabsorption syndrome.

Case Report: A 62-year-old woman was diagnosed with postmenopausal osteoporosis (serum iPTH: 61pg/mL) and received anti-osteoporotic medication (70mg alendronate sodium once weekly and 1g/800IU calcium carbonate/cholecalciferol daily). Read More

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http://dx.doi.org/10.2174/1574886313666180608080355DOI Listing
January 2019
2 Reads

Risk and Benefit Profile of Dulaglutide in Established Therapeutic Indication.

Curr Drug Saf 2018 ;13(3):165-170

Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga, Punjab, India.

Background: Recently, Food and Drug Administration (FDA) has approved Dulaglutide (GLP-1 analog) for the treatment of type 2 diabetes mellitus. However, regarding Adverse Drug Reactions (ADRs) of Dulaglutide in a large group of population, very less information is available. Thus, in the present investigation, we tried to find out the risk and benefit profile of Dulaglutide. Read More

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http://dx.doi.org/10.2174/1574886313666180601082412DOI Listing
January 2019
12 Reads

Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature.

Curr Drug Saf 2018 ;13(3):150-164

Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy.

Background: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated with a number of immune-related Adverse Events (AEs), including musculoskeletal and rheumatic disease.

Methods: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs induced by immune checkpoint inhibitors.

Results: Several musculoskeletal and rheumatic AEs associated with immune checkpoint inhibitors treatment are reported in the literature. Read More

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http://www.eurekaselect.com/161936/article
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http://dx.doi.org/10.2174/1574886313666180508122332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198478PMC
January 2019
27 Reads

Hyponatraemia Associated with Tramadol Use: A Case Report.

Curr Drug Saf 2018 ;13(3):217-220

Aged and Extended Care Services, The Queen Elizabeth Hospital, Australia.

Background: Hyponatraemia is frequently encountered in clinical practice and is common among hospitalized patients. Tramadol is a commonly prescribed analgesia with a few adverse effects. However, on rare occasions, tramadol has been found to be associated with hyponatraemia. Read More

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http://dx.doi.org/10.2174/1574886313666180508123232DOI Listing
January 2019
6 Reads

Register-Based Ecologic Evaluation of Safety Signals Related to Pneumococcal Conjugate Vaccine in Children.

Curr Drug Saf 2018 ;13(2):107-112

National Institute for Health and Welfare, Department of Public Health Solutions, Public Health Evaluation and Assessment Unit, Tampere, Finland.

Background: In clinical trials of Pneumococcal Conjugate Vaccines (PCV), some adverse events have been reported more frequently in the PCV vaccinated. Ten-valent PCV (PCV10) was introduced into the Finnish National Vaccination Programme (NVP) in September 2010.

Objective: We conducted an ecologic register-based study to investigate further the reported adverse events after PCV. Read More

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http://dx.doi.org/10.2174/1574886313666180406164151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094555PMC
October 2018
10 Reads