1,425 results match your criteria Current Drug Metabolism[Journal]


Effects of Radiation on Drug Metabolism: A Review.

Curr Drug Metab 2019 Apr 5. Epub 2019 Apr 5.

College of Ecological and Environment Engineering, Qinghai University, Xining. China.

Background: Radiation is the fourth most prevalent type of pollution following the water, air and noise pollution, it can adversely affect normal bodily functions. Radiation alters the protein and mRNA expression of drug-metabolizing enzymes and drug transporters and the pharmacokinetic characteristics of drugs, thereby affecting drug absorption, distribution, metabolism, and excretion. Therefore, it is important to study the pharmacokinetic changes in drugs under radiation. Read More

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http://dx.doi.org/10.2174/1389200220666190405171303DOI Listing
April 2019
2.976 Impact Factor

Letter to the Editor on "A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi".

Authors:
Arash Sadri

Curr Drug Metab 2019 Apr 2. Epub 2019 Apr 2.

Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran. Iran.

This letter is in reference to a recent article published in Current Drug Metabolism; A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi. Unfortunately, there is a major error mentioned in the material and method section of the study, which jeopardizes the study's goal. Read More

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http://dx.doi.org/10.2174/1389200220666190402125932DOI Listing

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure.

Curr Drug Metab 2019 Apr 2. Epub 2019 Apr 2.

Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University, Kakuma-machi, Kanazawa 9201192. Japan.

Background: Evidence has revealed that renal impairment can affect the systemic exposure of drugs which are predominantly eliminated via the liver. The modulation of drug-metabolizing enzymes and transporters expressed in the liver and/or small intestine by diverse entities, including uremic toxins, in systemic circulation of patients with severe renal failure is considered as the cause of atypical pharmacokinetics, which sometimes induce undesirable adverse events that are especially critical for drugs with narrow therapeutic window such as anticancer drugs. A dosing strategy for anticancer drugs in these patients need to be established. Read More

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http://dx.doi.org/10.2174/1389200220666190402143125DOI Listing
April 2019
3 Reads

Herb-Drug Interactions and Hepatotoxicity.

Curr Drug Metab 2019 Mar 25. Epub 2019 Mar 25.

National Agri-Food Biotechnology Institute, Mohali, Punjab 140306. India.

Background: In recent times, herbals or phytomedicines have become very popular due to their global acceptance as complementary and alternative remedy. While modern drugs are commercially available only after laboratory validations, clinical trials as well as approval from drug regulatory authorities, majority of marketed herbal products lack such scientific evidences of efficacy and safety. This results in herb or herb-drug interaction induced unfavorable clinical outcomes without crucial documentation on their temporal relations and concomitant use. Read More

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http://dx.doi.org/10.2174/1389200220666190325141422DOI Listing
March 2019
2 Reads

Tubular and Glomerular Biomarkers of Acute Kidney Injury in Newborns.

Curr Drug Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatrics and Nephrology, Medical University of Bialystok, Białystok. Poland.

Background: Acute Kidney Injury (AKI) is a sudden decrease in kidney function. In the early period, the highest percentage of AKI occurs among newborns hospitalized in neonatal intensive care units, especially premature neonates. The prognosis of AKI depends on the type and severity of the cause of an injury, the accuracy and the time of diagnosis and treatment. Read More

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http://dx.doi.org/10.2174/1389200220666190321142417DOI Listing
March 2019
1 Read

Crosstalk Between Nutrients and Xenobiotic Receptors.

Authors:
Xi Ma

Curr Drug Metab 2019 ;20(1)

State Key Laboratory of Animal Nutrition Ministry of Agriculture Feed Industry Centre (MAFIC) College of Animal Science and Technology China Agricultural University (CAU) Beijing, China.

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http://dx.doi.org/10.2174/138920022001190125110856DOI Listing
January 2019

Preface.

Authors:
Michael Sinz

Curr Drug Metab 2019 ;20(1)

Bristol Myers Squibb Princeton, NJ, United States.

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http://dx.doi.org/10.2174/138920022001190125110659DOI Listing
January 2019

Recent Findings on Nanotechnology-based Therapeutic Strategies against Hepatocellular Carcinoma.

Curr Drug Metab 2019 Mar 8. Epub 2019 Mar 8.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.

Background: Nanotechnology-based therapies are emerging as a promising new anticancer approach. Early clinical studies suggest that nanoparticle-based therapeutics can show enhanced efficacy while reducing side effects minimal, owing to targeted delivery and active intracellular uptake.

Methods: To overcome the problems of gene and drug delivery, nanotechnology based delivery system gained interest in the last two decades. Read More

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http://dx.doi.org/10.2174/1389200220666190308134351DOI Listing
March 2019
9 Reads

PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease.

Curr Drug Metab 2019 Feb 27. Epub 2019 Feb 27.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, . China.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a systematic inflammatory disease, and smoking is an important risk factor for COPD. Macrolide can reduce COPD inflammation. However, the inflammatory mechanism of COPD is remain unclear and the anti-inflammatory mechanism of Macrolide is complex and not exactly known. Read More

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http://dx.doi.org/10.2174/1389200220666190227224748DOI Listing
February 2019

Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy.

Curr Drug Metab 2019 Feb 25. Epub 2019 Feb 25.

Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona. Italy.

Background: Research of biomarkers in genitourinary tumors goes along with development of complex emerging techniques ranging from next generation sequencing platforms, applied to archival pathology specimens, cytological samples, liquid biopsies, and to patient-derived tumor models.

Method: This contribution is an update on molecular biomarkers for diagnosis, prognosis and prediction of response to therapy in genitourinary tumors. The following major topics are dealt with: Immunological biomarkers, including the microbiome, and their potential role and caveats in renal cell carcinoma, bladder and prostate cancers and testicular germ cell tumors; Tissue biomarkers for imaging and therapy, with emphasis on Prostate-specific membrane antigen in prostate cancer; Liquid biomarkers in prostate cancer, including circulating tumor cell isolation and characterization in renal cell carcinoma, bladder cancer with emphasis on biomarkers detectable in the urine and testicular germ cell tumors; and Biomarkers and economic sustainability. Read More

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http://dx.doi.org/10.2174/1389200220666190225124352DOI Listing
February 2019
10 Reads

Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/Accelerator Mass Spectrometry

Curr Drug Metab 2019 02 6. Epub 2019 Feb 6.

Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil. Switzerland.

Background: As part of an integrated and innovative approach to accelerate the clinical development of the dual receptor antagonist ACT-541468, 6 healthy subjects in one cohort in a first-in-humans (FIH) study received an oral dose of 50 mg non-labeled ACT-541468 together with a microtracer amount of 250 nCi of 14C-labeled ACT-541468 to investigate its absorption, distribution, metabolism, and excretion (ADME).

Methods: Using accelerator mass spectrometry (AMS), radiochromatograms were constructed for fractionated plasma, urine, and feces samples. Subsequently, the structures of the metabolites were elucidated using high performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry. Read More

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http://dx.doi.org/10.2174/1389200220666190206141814DOI Listing
February 2019
2.976 Impact Factor

Clinical Implications Of Methotrexate Pharmacogenetics In Childhood Acute Lymphoblastic Leukaemia.

Curr Drug Metab 2019 Jan 30. Epub 2019 Jan 30.

Department of Medical & Surgical Therapeutics, Medical School, University of Extremadura, Av. Elvas s/n 06006, Badajoz. Spain.

In the past two decades, a great body of research has been published regarding the effects of genetic polymorphisms on methotrexate (MTX)-induced toxicity and efficacy. Of particular interest is the role of this compound in childhood acute lymphoblastic leukaemia (ALL), where it is a pivotal drug in the different treatment protocols, both at low and high doses. MTX acts on a variety of target enzymes in the folates cycle, as well as being transported out and into of the cell by several transmembrane proteins. Read More

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http://dx.doi.org/10.2174/1389200220666190130161758DOI Listing
January 2019
1 Read

Recent Advances on Prediction of Human Papillomaviruses Risk Types.

Curr Drug Metab 2019 Jan 17. Epub 2019 Jan 17.

School of Mathematics and Statistics, Hainan Normal University . China.

Background: Some studies have shown that human papillomavirus (HPV) is strongly associated with cervical cancer. As we all know, cervical cancer still remains the fourth most common cancer, affecting women worldwide. Thus, it is both challenging and essential to detect risk types of human papillomaviruses. Read More

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http://dx.doi.org/10.2174/1389200220666190118110012DOI Listing
January 2019
2 Reads

Effects of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics: A systematic review and meta-analysis.

Curr Drug Metab 2019 Jan 10. Epub 2019 Jan 10.

Department of Pharmacy, Peking University First Hospital, Beijing 100034. China.

Objective: The purpose of this systematic review and meta-analysis was to summarize the potential impact of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics.

Method: A systematic search was conducted using electronic databases. Eligible studies reported data from pharmacokinetic evaluations of repaglinide in healthy adults according to different categories of CYP2C8 and SLCO1B1 genetic polymorphisms. Read More

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http://dx.doi.org/10.2174/1389200220666190111114146DOI Listing
January 2019
1 Read

The Effects of Genetic Polymorphisms in Pharmacokinetics and Pharmacodynamics Parameters.

Authors:
Ji-Fu Wei

Curr Drug Metab 2018 ;19(14):1140

Research Division of Clinical Pharmacology The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.

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http://dx.doi.org/10.2174/138920021914181211113837DOI Listing
January 2018
1 Read

A metabonomics approach to drug toxicology in liver disease and its application in Traditional Chinese Medicine.

Curr Drug Metab 2018 Dec 31. Epub 2018 Dec 31.

Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016. China.

Background: The progression of liver disease causes metabolic transformation in vivo and thus affects corresponding endogenous small molecular compounds. Metabonomics is a powerful technology which is able to assess global low-molecular-weight endogenous metabolites in a biological system. This review is intended to provide an overview of a metabonomics approach to the drug toxicology of diseases of the liver. Read More

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http://dx.doi.org/10.2174/1389200220666181231124439DOI Listing
December 2018
1 Read

Progress in the Consideration of Possible Sex Differences in Drug Interaction Studies.

Curr Drug Metab 2018 Nov 28. Epub 2018 Nov 28.

Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu Natal, KwaZulu Natal. South Africa.

Background: Anecdotal evidence suggests that there may be sex differences in Drug-drug Interactions (DDI) involving specific drugs. Regulators have provided general guidance for the inclusion of females in clinical studies. Some clinical studies have reported sex differences in the Pharmacokinetics (PK) of CYP3A4 substrates, suggesting that DDI involving CYP3A4 substrates could potentially show sex differences. Read More

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http://dx.doi.org/10.2174/1389200220666181128160813DOI Listing
November 2018
1 Read
2.976 Impact Factor

GHB Pharmacology and Toxicology: From Metabolism and Pharmacokinetics to Applications: In Clinical and Forensic Toxicology.

Curr Drug Metab 2018 ;19(13):1054-1055

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

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http://dx.doi.org/10.2174/138920021913181029122146DOI Listing
February 2019
3 Reads

Removal of Pharmaceutical Contaminants in Wastewater using Nanomaterials: A Comprehensive Review.

Curr Drug Metab 2018 Nov 26. Epub 2018 Nov 26.

Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala-147004, Punjab. India.

Background: The limitless presence of pharmaceutical contaminants in discharged wastewater has emerged as a threat to aquatic species and humans. Their presence in drinking water has although raised substantial concerns, very little is known about the fate and ecological impacts of these pollutants. As a result, these pollutants are inevitably introduced to our food chain at trace concentrations. Read More

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http://dx.doi.org/10.2174/1389200220666181127104812DOI Listing
November 2018
1 Read

Nanotherapeutics for the treatment of cancer and arthritis.

Curr Drug Metab 2018 Nov 26. Epub 2018 Nov 26.

Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad, 380009, Gujarat. India.

Nanotechnology is gaining significant attention worldwide for the treatment of complex disease such as AIDS (acquired immune deficiency syndrome), cancer and rheumatoid arthritis. Nanomedicine is the application of nanotechnology used for diagnosis and treatment for the disease that includes the preservation and improvement of human health by covering an area such as drug delivery using nanocarriers, nanotheranostics and nanovaccinology. The present article provides an insight on several aspects of nanomedicine such as usages of multiple type of nanocarriers, their status, advantages and disadvantages with reference to cancer and rheumatoid arthritis. Read More

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http://dx.doi.org/10.2174/1389200220666181127102720DOI Listing
November 2018
17 Reads

Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine.

Curr Drug Metab 2018 Nov 22. Epub 2018 Nov 22.

Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad 380009, Gujarat. India.

Background: Biomedical applications of Magnetic Nanoparticles (MNPs) are creating major impact in disease diagnosis and nanomedicine or a combined platform called theranostics. A significant progress has been made to engineer novel and hybrid MNPs for their multifunctional modalities such as imaging, biosensors, chemotherapeutic or photothermal and antimicrobial agents. MNPs are successfully applied in biomedical applications due to their unique and tunable properties such as superparamagnetism, stability, and biocompatibility. Read More

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http://dx.doi.org/10.2174/1389200220666181122124458DOI Listing
November 2018
13 Reads

Iron oxide nanoparticles for breast cancer theranostics.

Curr Drug Metab 2018 11 21. Epub 2018 Nov 21.

Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Savar, Dhaka-1342. Bangladesh.

Background: Breast cancer is the second leading cause of death in women worldwide. The extremely fast rate of metastasis and ability to develop resistance mechanism to all the conventional drugs make them very difficult to treat which are the causes of high morbidity and mortality of breast cancer patients. Scientists throughout the world have been focusing on the early detection of breast tumor so that treatment can be started at the very early stage. Read More

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http://dx.doi.org/10.2174/1389200220666181122105043DOI Listing
November 2018
26 Reads

Recent advances in machine learning methods for predicting heat shock proteins.

Curr Drug Metab 2018 10 30. Epub 2018 Oct 30.

School of Sciences, and Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan 063000, China

Background: As molecular chaperones, heat shock proteins (HSPs) not only play key roles in protein folding and maintaining protein stabilities, but also linked with multiple kinds of diseases. Therefore, HSPs have been regarded as the focus of drug design. Since HSPs from different families play distinct functions, accurately classifying the families of HSPs is the key step to clearly understand their biological functions. Read More

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http://dx.doi.org/10.2174/1389200219666181031105916DOI Listing
October 2018
17 Reads
2.980 Impact Factor

Metabolic Pathway of Cyclosporine A and Its Correlation with Nephrotoxicity.

Curr Drug Metab 2018 Oct 31. Epub 2018 Oct 31.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove. Czech Republic.

Cyclosporine A (CsA) is widely used for organ transplantation and autoimmune disorders. However, CsA nephrotoxicity is a serious side effect that limits the clinical use of CsA. Notably, the metabolism of CsA has a close relationship with this disease in renal-transplant patients. Read More

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http://dx.doi.org/10.2174/1389200219666181031113505DOI Listing
October 2018
3 Reads

Iron and Vitamin D/Calcium Deficiency after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition

Curr Drug Metab 2018 10 26. Epub 2018 Oct 26.

Diabetes Complications Research Center, Conway Institute, University College Dublin, Dublin, Ireland

Background: Nutritional deficiencies are common following Roux-en-Y gastric bypass (RYGB). Aetiology is diverse; including unresolved preoperative deficiency, post-operative malabsorption and reduced food intake. Iron and calcium/vitamin D deficiency are particularly troublesome following RYGB. Read More

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http://dx.doi.org/10.2174/1389200219666181026160242DOI Listing
October 2018
3 Reads

Anti-leishmanial Nanotherapeutics: A Current Perspective.

Curr Drug Metab 2018 Oct 22. Epub 2018 Oct 22.

Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad, Gujarat -380009. India.

Leishmaniasis is a dreaded disease caused by protozoan parasites belonging to the genus Leishmania which results in significant morbidity and mortality worldwide. There are no vaccines available currently for the treatment of Leishmaniasis and chemotherapy still remains the mainstay for anti-leishmanial therapeutics. However, toxicity, reduced bioavailability, high cost and chemoresistance are the principal problems which limit the use of the available drugs. Read More

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http://www.eurekaselect.com/166534/article
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http://dx.doi.org/10.2174/1389200219666181022163424DOI Listing
October 2018
14 Reads

Survey of Machine Learning Techniques for Prediction of the Isoform Specificity of Cytochrome P450 Substrates.

Curr Drug Metab 2018 Oct 18. Epub 2018 Oct 18.

State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240. China.

Background: Determination or prediction of the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates and drug-induced toxicity play crucial roles in drug discovery and development. Metabolism is one of the most complicated pharmacokinetic properties to be understood and predicted. However, experimental determination of the substrate binding, selectivity, sites and rates of metabolism is time- and recourse- consuming. Read More

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http://dx.doi.org/10.2174/1389200219666181019094526DOI Listing
October 2018
2 Reads

Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use under Hypoxic Conditions at High Altitudes.

Curr Drug Metab 2018 Oct 19. Epub 2018 Oct 19.

School of Pharmacy, Lanzhou University, Lanzhou, 730000, Gansu. China.

Background: Modern features of drug development such as low permeability, low solubility, and improved release affect the interplay of the gut microbiota and drug metabolism. In recent years, studies have established the impact of plateau hypoxia on gut microbiota, where drug use by plateau populations is affected by hypoxia-induced changes in intestinal microflora-mediated drug metabolism.

Methods: In this review, we summarized the effects of gut microbiota on drug metabolism, and of plateau hypoxia on the intestinal flora, with the aim of providing guidance for the rational use of drugs in high-altitude populations. Read More

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http://dx.doi.org/10.2174/1389200219666181019145159DOI Listing
October 2018
3 Reads

Machine Learning in Quantitative Protein-Peptide Affinity Prediction: Implications for Therapeutic Peptide Design.

Curr Drug Metab 2018 Oct 12. Epub 2018 Oct 12.

Center for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu 610054. China.

Background: Protein-peptide recognition plays an essential role in the orchestration and regulation of cell signaling networks, which is estimated to be responsible for up to 40% of biological interaction events in the human interactome and has recently been recognized as a new and attractive druggable target for drug development and disease intervention.

Methods: We present a systematic review on the application of machine learning techniques in the quantitative modeling and prediction of protein-peptide binding affinity, particularly focusing on its implications for therapeutic peptide design. We also briefly introduce the physical quantities used to characterize protein-peptide affinity and attempt to extend the content of generalized machine learning methods. Read More

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http://dx.doi.org/10.2174/1389200219666181012151944DOI Listing
October 2018
3 Reads

Advances and Application of a Novel Oral Anticoagulant in Specific Populations: Dabigatran Etexilate.

Curr Drug Metab 2018 Oct 11. Epub 2018 Oct 11.

Department of Pharmacy Suzhou, The Second Affiliated Hospital of Soochow University, Jiangsu. China.

Dabigatran etexilate (DE) was approved by the FDA in 2010 to reduce the risk of stroke and systemic embolism in adults with non-valvular atrial fibrillation (NVAF). Compared with warfarin, a traditional anticoagulant drug, DE exhibits a shorter half-life, improved dose-effect relationship, fewer food and drug interactions, and can be taken orally without monitoring the conventional coagulation index. DE can also prevent or reduce the severity of adverse events, such as attenuated drug efficacy or bleeding. Read More

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http://dx.doi.org/10.2174/1389200219666181011160133DOI Listing
October 2018
1 Read

The Development of Machine Learning Methods in Cell-Penetrating Peptides Identification: A Brief Review.

Curr Drug Metab 2018 Oct 10. Epub 2018 Oct 10.

Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu. China.

Background: Cell-penetrating peptides (CPPs) are important short peptides that facilitate cellular intake or uptake of various molecules. CPPs can transport drug molecules through the plasma membrane and send these molecules to different cellular organelles. Thus, CPP identification and related mechanisms have been extensively explored. Read More

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http://dx.doi.org/10.2174/1389200219666181010114750DOI Listing
October 2018
2 Reads

Survey of Drug Oxidation Activities in Liver and Intestine Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model.

Curr Drug Metab 2018 Oct 3. Epub 2018 Oct 3.

Showa Pharmaceutical University, Machida, Tokyo 194-8543. Japan.

Background: Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. Information for major drug-metabolizing cytochrome P450 (P450) enzymes is now available that supports the use of this primate species as an animal model for drug development. Here, we collect and provide an overview of information on the activities of common marmoset liver and intestine microsomes with respect to 28 typical human P450 probe oxidations. Read More

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http://www.eurekaselect.com/165907/article
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http://dx.doi.org/10.2174/1389200219666181003143312DOI Listing
October 2018
5 Reads

Drug-drug interactions of P-gp substrates unrelated to CYP metabolism.

Curr Drug Metab 2018 10 3. Epub 2018 Oct 3.

Department of Hospital Pharmacy, Zikeikai-Aoimori Hospital, Aomori. Japan.

Background: Recent US Food and Drug Administration (FDA) draft guidance on pharmacokinetic drug-drug interactions (DDIs) has highlighted the clinical importance of ABC transporters B1 or P-glycoprotein (P-gp), hepatic organic anion-transporting polypeptide transporters and breast cancer resistant protein because of their broad substrate specificity and the potential to be involved in DDIs. This guidance has indicated that digoxin, dabigatran etexilate and fexofenadine are P-gp substrate drugs and has defined P-gp inhibitors as those that increase the AUC of digoxin by ≧1.25-fold in clinical DDI studies. Read More

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http://www.eurekaselect.com/165904/article
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http://dx.doi.org/10.2174/1389200219666181003142036DOI Listing
October 2018
2 Reads

Replacing GHB with GBL in Recreational Settings: A New Trend in Chemsex.

Curr Drug Metab 2018 ;19(13):1080-1085

Unit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, V.Le Regina Elena 336, 00161, Rome, Italy.

Background: Recently, Gamma-hydroxybutyrate (GHB) consumption in the recreational setting has been replaced by that of its prodrug Gamma-butyrolactone (GBL), cheaper and easier to obtain due to several legal industrial applications.

Objective: The aim of the present paper was to report the most authoritative literature on the pharmacology and toxicology of GBL, dependence and abuse potential and the related public health issues together with the results of the analyses of several illicit liquid preparations containing GHB/GBL generally sold as "G".

Method: International literature concerning "Gamma-butyrolactone", "GBL" "toxicology", "pharmacology", "abuse", "dependence" and "GHB has been reviewed and liquid preparations containing GHB/GBL analysed by ultra-high performance liquid chromatography coupled to the tandem mass spectrometry validated methodology. Read More

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http://dx.doi.org/10.2174/1389200219666180925090834DOI Listing
February 2019
10 Reads

Influence of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics/Pharmacodynamics of Tacrolimus in Pediatric Patients.

Curr Drug Metab 2018 ;19(14):1141-1151

Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, China.

Background: Single Nucleotide Polymorphisms (SNPs) are very common variants of many genes and are also promising markers associated with drug reactions in pharmacogenomics research. In pediatric organ transplantation, tacrolimus is a major immunosuppressive agent used to prevent organ rejection. The SNP of these genes have been studied extensively in adult population, but there is no systematic review in children. Read More

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http://dx.doi.org/10.2174/1389200219666180925090228DOI Listing
January 2018
4 Reads

A Review of Theranostics Applications and Toxicities of Carbon Nanomaterials.

Curr Drug Metab 2018 Sep 24. Epub 2018 Sep 24.

School of Nano Sciences, Central University of Gujarat, Sector 30, Gandhinagar-382030. India.

Background: In last few years, the use of modified carbon nanomaterials (CNMs) for theranostics (therapeutic and diagnosis) applications is a new and rapidly growing area in pharmacy and medical fields. Owing to this, their unique physical and chemical properties like high stability, high drug loading with high surface to volume ratio, low toxicity are mainly responsible to be considered those as smart nanomaterials.

Objective: This review describes the different sizes, shapes, and dimensions of carbon-based nanocarriers including 0-D fullerene, 1-D CNTs, and 2-D graphene and graphene oxide and their surface modification with different biocompatible and biodegradable molecules via covalent or non-covalent functionalization. Read More

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http://www.eurekaselect.com/165624/article
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http://dx.doi.org/10.2174/1389200219666180925094515DOI Listing
September 2018
22 Reads

A Review of Recent Advances and Research on Drug Target Identification Methods.

Curr Drug Metab 2018 Sep 24. Epub 2018 Sep 24.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081. China.

From a therapeutic viewpoint, understanding how drugs bind and regulate the functions of their target proteins to protect against disease is crucial. The identification of drug targets plays a significant role in drug discovery and in studying the mechanisms of diseases. The development of methods to identify drug targets has become a popular issue in this field of research. Read More

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http://dx.doi.org/10.2174/1389200219666180925091851DOI Listing
September 2018
16 Reads

The Role of Xenobiotic Receptors on Hepatic Glycolipid Metabolism.

Curr Drug Metab 2019 ;20(1):29-35

Department of Otolaryngology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: PXR (Pregnane X Receptor) and CAR (Constitutive Androstane Receptor) are termed as xenobiotic receptors, which are known as core factors in regulation of the transcription of metabolic enzymes and drug transporters. However, accumulating evidence has shown that PXR and CAR exert their effects on energy metabolism through the regulation of gluconeogenesis, lipogenesis and β-oxidation. Therefore, in this review, we are trying to summary recent advances to show how xenobiotic receptors regulate energy metabolism. Read More

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http://dx.doi.org/10.2174/1389200219666180918152241DOI Listing
January 2019
7 Reads

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy.

Curr Drug Metab 2018 Sep 18. Epub 2018 Sep 18.

Centre of Biotechnology, University of Allahabad, Allahabad-211002. India.

Background- Nanotechnology is gaining significant attention worldwide for cancer treatment. Nano-biotechnology encourages the combination of diagnostics with therapeutics, which is a vital component of a customized way to deal with the malignancy. Nanoparticles are being used as Nanomedicine which participates in diagnosis and treatment of various diseases including cancer. Read More

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http://dx.doi.org/10.2174/1389200219666180918111528DOI Listing
September 2018
2 Reads

Advanced Glycation End Products (AGEs), Glutathione and Breast Cancer: Factors, Mechanism and Therapeutic Interventions.

Curr Drug Metab 2019 ;20(1):65-71

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Advanced Glycation End products (AGEs) are basically the end result of glycation of proteins and/or lipids in the presence of sugars. Specific cases of hyperglycemia have been reported with increased propensity of generation of AGEs. Many chronic and deadly diseases such as diabetes, cancer and neurodegenerative disorders have been known to be caused as a result of generation of AGEs. Read More

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http://dx.doi.org/10.2174/1389200219666180912104342DOI Listing
January 2019
23 Reads
2.980 Impact Factor

Novel Nanoparticles for Tumor Targeting Drug Delivery.

Authors:
Huile Gao

Curr Drug Metab 2018 ;19(9):722

Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University Chengdu, China.

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http://dx.doi.org/10.2174/138920021909180829163810DOI Listing
January 2018
17 Reads

Targeting Virus-host Protein Interactions: Feature Extraction and Machine Learning Approaches.

Curr Drug Metab 2018 Aug 29. Epub 2018 Aug 29.

School of Software, Central South University, Changsha, 410075. China.

Virus-host protein interactions play essential roles in viral infection and antiviral defenses. Targeting critical viral-host protein-protein interactions (PPIs) has enormous application prospects for therapeutics. Using experimental methods to evaluate all possible virus-host PPIs takes a great deal of money and time. Read More

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http://dx.doi.org/10.2174/1389200219666180829121038DOI Listing
August 2018
1 Read

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics.

Authors:
Li Di

Curr Drug Metab 2018 Aug 20. Epub 2018 Aug 20.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. United States.

Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters, amides, carbamates and thioesters, and bioconverting prodrugs and soft drugs. Human CES1 is one of the most highly expressed drug metabolizing enzymes in the liver, while human intestine only expresses CES2. The unique tissue distribution of CES enzymes provides great opportunities to design prodrugs or soft drugs for tissue targeting. Read More

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http://www.eurekaselect.com/164805/article
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http://dx.doi.org/10.2174/1389200219666180821094502DOI Listing
August 2018
22 Reads

Recent advances in the machine learning-based drug-target interaction prediction.

Curr Drug Metab 2018 Aug 20. Epub 2018 Aug 20.

School of Mathematics and Statistics, South-central University for Nationalities, Wuhan 430074. China.

The identification of drug-target interactions is a crucial issue in drug discovery. In recent years, researchers have made great efforts on the drug-target interaction predictions, and developed databases, software and computational methods. In the paper, we review the recent advances of machine learning-based drug-target interaction prediction. Read More

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http://dx.doi.org/10.2174/1389200219666180821094047DOI Listing
August 2018
3 Reads

Molecular Design of Peptide-Fc Fusion Drugs.

Curr Drug Metab 2018 Aug 20. Epub 2018 Aug 20.

Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu. China.

Peptide-Fc fusion drugs are a category of biological therapeutics in which the Fc region of an antibody is genetically fused to a peptide of interest. In this review, we summarize the key steps in peptide-Fc fusion technology and stress the main computational resources, tools, and methods that have been used in the rational design of peptide-Fc fusion drugs. Additionally, open questions about the computer-aided molecular design of peptide-Fc are raised. Read More

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http://dx.doi.org/10.2174/1389200219666180821095355DOI Listing
August 2018
17 Reads

Survey of Machine Learning Techniques in Drug Discovery.

Curr Drug Metab 2018 Aug 19. Epub 2018 Aug 19.

Department of Computer Science, Pacific Lutheran University, Tacoma, WA 98447. United States.

Drug discovery, which is the process of discovering new candidate medications, is very important for pharmaceutical industries. At its current stage, discovering new drugs is still an expensive and time-consuming process, requiring Phases I, II and III for clinical trials. Recently, machine learning techniques in Artificial Intelligence (AI), especially the deep learning techniques which allow a computational model to generate multiple layers, have been widely applied and achieved state-of-the-art performance in various fields, such as speech recognition, image classification, bioinformatics, etc. Read More

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http://dx.doi.org/10.2174/1389200219666180820112457DOI Listing
August 2018
4 Reads

Interindividual Variability in Drug Metabolizing Enzymes.

Authors:
Donna A Volpe

Curr Drug Metab 2018 Aug 17. Epub 2018 Aug 17.

Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD. United States.

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http://dx.doi.org/10.2174/1389200219666180817144411DOI Listing
August 2018
2 Reads

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors, Reality or Dream in Managing Patients with Cardiovascular Disease.

Curr Drug Metab 2019 ;20(1):72-82

Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

Background: Statins have been a major keystone in the management of patients with atherosclerotic cardiovascular disease. The benefits of inhibiting HMG CoA reductase, via statins, were translated into reduction in LDL-c with proportionate decrease in cardiovascular events in response to the magnitude of LDL-c reduction. Despite major advances in pharmacological treatments, including the use of high-dose statins, there are urgent need to further reduce future cardiovascular risk. Read More

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http://dx.doi.org/10.2174/1389200219666180816141827DOI Listing
January 2019
1 Read

Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug.

Curr Drug Metab 2018 Aug 16. Epub 2018 Aug 16.

School of Life Sciences, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University, Wuhan 430062. China.

Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong anti-proliferative activity on all 60-national cancer institute (NCI) cancer cell lines. The antitumor property of triptolide has made it become a promising anti-cancer drug. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. Read More

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http://dx.doi.org/10.2174/1389200219666180816141506DOI Listing
August 2018
7 Reads

Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Ddatabase.

Curr Drug Metab 2018 08 13. Epub 2018 Aug 13.

Tianjin University of Traditional Chinese Medicine, Tianjin 300193. China.

This review summarizes the current research status of hepatotoxicity and points out that drug induced liver injury (DILI) remains an important scientific problem that urgently needs to be solved. Due to the special nature of Chinese Herbal medicine and the complexity of its clinical use, it is difficult to identify and evaluate its toxicity and resulting herb induced liver injury (HILI). At the same time, due to a lack of specific indicators, the direct and indirect long-term effects of Chinese Herbal Medicine on the liver are also difficult to be clinically determined. Read More

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http://dx.doi.org/10.2174/1389200219666180813144114DOI Listing
August 2018
7 Reads