1,119 results match your criteria Current Drug Delivery[Journal]


Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery.

Curr Drug Deliv 2019 Jan 23. Epub 2019 Jan 23.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072. Australia.

Subunit vaccines are composed of pathogen fragments that, on their own, are generally poorly immunogenic. Therefore, the incorporation of an immunostimulating agent, e.g. Read More

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http://dx.doi.org/10.2174/1567201816666190123120915DOI Listing
January 2019

Topical and transdermal drug delivery: from simple potions to smart technologies.

Curr Drug Deliv 2019 Feb 1. Epub 2019 Feb 1.

Diamantina Institute, The University of Queensland, Translational Research Institute, QLD, 4102. Australia.

This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. Major changes have occurred in our understanding of the skin and the sophistication in our technology to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. Read More

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http://dx.doi.org/10.2174/1567201816666190201143457DOI Listing
February 2019

Nanomedicines as Drug Delivery Carriers of Anti-Tubercular Drugs: From Pathogenesis to Infection Control.

Curr Drug Deliv 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451. Saudi Arabia.

In spite of advances in tuberculosis (TB) chemotherapy, TB is still air-born deadly disorder as major issue of health concern worldwide today. Extensive researches have been focused to develop novel drug delivery systems to shorten the lengthy therapy approaches, prevention of relapses, reducing dose related toxicities and to rectify technological related drawbacks of anti-tubercular drugs. Moreover, rapid emergence of drug resistance, poor patient compliance due to negative therapeutic outcomes and intracellular survival of Mycobacterium highlighted to develop carrier with optimum effectiveness of the anti-tubercular drugs. Read More

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http://dx.doi.org/10.2174/1567201816666190201144815DOI Listing
February 2019
1 Read

Fenofibrate Solid Dispersion Processed by Hot-melt Extrusion: Elevated Bioavailability and Its Cell Transport Mechanism.

Curr Drug Deliv 2019 Jan 22. Epub 2019 Jan 22.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006. China.

Background: Fenofibrate (FNB) is an effective drug for the treatment of hypertriglyceridemia, hypercholesterolemia as well as mixed hyperlipidemia. However, due to its poor aqueous solubility, FNB exists the problem of poor oral absorption followed by low bioavailability.

Objective: The aim of this research was to construct FNB amorphous solid dispersion employing PVP VA64 as the carrier by hot-melt extrusion method, in order to improve the oral bioavailability. Read More

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http://dx.doi.org/10.2174/1567201816666190122123044DOI Listing
January 2019

Stimulus sensitive smart nano platforms: an emerging paradigm for the treatment of skin diseases.

Curr Drug Deliv 2019 Jan 23. Epub 2019 Jan 23.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab. India.

Background: Over the past century, prevalence of skin diseases has substantially increased. These diseases present a significant physical, emotional and socio-economic burden to the society. Such conditions are also associated with multitude of psychological traumas to the suffering patients. Read More

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http://dx.doi.org/10.2174/1567201816666190123125813DOI Listing
January 2019
5 Reads
2.248 Impact Factor

Indinavir-Loaded Nanostructured Lipid Carriers to Brain Drug Delivery: Optimization, Characterization and Neuropharmacokinetic Evaluation.

Curr Drug Deliv 2019 Jan 23. Epub 2019 Jan 23.

Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC), Zanjan University of Medical Sciences, Postal Code 45139-56184, Zanjan. Iran.

As an anti-retroviral protease inhibitor (PI), indinavir (IDV) is part of the regimen known as Highly Active Anti-Retroviral Therapy (HAART) widely used for Human Immunodeficiency Virus (HIV) infection. The drug efficiency in treatment of the brain manifestations of HIV is, however, limited which is mainly due to the efflux by P-glycoprotein (P-gp) expressed at the Blood-Brain Barrier (BBB). To overcome the BBB obstacle, NLCs was attempted in this study as carriers for IDV, which was optimized through two steps: a "one-factor-at-a-time" screening followed by a systematic multi-objective optimization. Read More

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http://dx.doi.org/10.2174/1567201816666190123124429DOI Listing
January 2019
1 Read

An Overview of Chitosan Nanofibers and their Applications in Drug Delivery Process.

Curr Drug Deliv 2019 01 23. Epub 2019 Jan 23.

Center of Excellence for Advanced Research in Fluid Flow (CARIFF), Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang, Gambang 26300, Kuantan. Malaysia.

Chitosan is a polycationic natural polymer which is abundant in nature. Chitosan has gained much attention as natural polymer in the biomedical field. The up to date drug delivery as well as the nanotechnology in controlled release of drugs from chitosan nanofibers are focused in this review. Read More

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http://dx.doi.org/10.2174/1567201816666190123121425DOI Listing
January 2019
1 Read

Medicated foams and film forming dosage forms as tools to improve the thermodynamic activity of drugs to be administered through the skin.

Curr Drug Deliv 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmaceutical Sciences, University of Milan, Via G. Colombo, 71 - 20133 Milan . Italy.

Medicated foams and film forming systems are dosage forms formulated to undergo to a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate a foam when applied on the stratum corneum, or a liquid or conventional dosage form can form on the skin a continuous film as a consequence of the solvent evaporation. Thanks to these controlled modifications, the drug thermodynamic activity increases favoring the skin penetration and, therefore, the bioavailability with respect to conventional semi-solid and liquid dosage forms. Read More

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http://www.eurekaselect.com/169127/article
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http://dx.doi.org/10.2174/1567201816666190118124439DOI Listing
January 2019
4 Reads

Advanced of Lipid based Nanocarriers and Combination Application with Physical Penetration Technique.

Curr Drug Deliv 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032. China.

On account of the advantages of transdermal delivery and the application situation of transcutaneous technology in transdermal delivery, the article critically comments nanosystems as permeation enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This review focuses on recent advances in lipid based nanocarriers, including liposome, transfersomes, ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination application of the lipid based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis in the field for the development of the transdermal drug delivery system. Read More

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http://www.eurekaselect.com/169129/article
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http://dx.doi.org/10.2174/1567201816666190118125427DOI Listing
January 2019
5 Reads

The Effect of Focused Ultrasound on Magnetic Polyelectrolyte Capsules Loaded with Dye When Suspended in Tissue-Mimicking Gel.

Curr Drug Deliv 2019 Jan 3. Epub 2019 Jan 3.

Faculty of Health and Life Sciences, Coventry University, Coventry, Priory Street, West Midlands, CV1 5FB, Coventry. United Kingdom.

Capsules containing a dye were prepared by the LbL method with iron oxide nanoparticles (50 nm) in different layers of the shell. The capsules were dispersed in a gel and subjected to focused ultrasonic irradiation at three different powers and exposure times. It was found that the inclusion of iron oxide magnetic nanoparticles in any of the polyelectrolyte shells (4, 6, 8 and 10) strengthened the capsules with respect to capsules without nanoparticles. Read More

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http://dx.doi.org/10.2174/1567201816666190103121313DOI Listing
January 2019
1 Read

Probucol Self-Emulsified Drug Delivery System: Stability Testing and Bioavailability Assessment in Human Volunteers.

Curr Drug Deliv 2018 Dec 26. Epub 2018 Dec 26.

Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University. Kuwait.

Self-emulsifying drug delivery system (SEDDS), if taken orally, is expected to self-emulsify in GIT and improve the absorption and bioavailability. Probucol (PB) is a highly lipophilic compound with very low and variable bioavailability. The objectives of this study were to examine the stability and conduct bioavailability of the prepared probucol self-emulsified drug delivery system (PBSEDDS) in human volunteers. Read More

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http://www.eurekaselect.com/168603/article
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http://dx.doi.org/10.2174/1567201816666181227111912DOI Listing
December 2018
9 Reads

Novel drug targets with traditional herbal medicines for overcoming endometriosis.

Curr Drug Deliv 2018 Dec 26. Epub 2018 Dec 26.

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara. Turkey.

Endometriosis is a disease in which the lining of the endometrium is found outside of the uterus. Recent medical treatments for endometriosis have adverse effects, limiting their long-term use. Furthermore, the recurrence of the disease after the cessation of therapy is quite common, and most patients need to continue treatment to maintain a hypoestrogenic environment till conception. Read More

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http://dx.doi.org/10.2174/1567201816666181227112421DOI Listing
December 2018
10 Reads

Design of Experiments (DoE) Approach to Optimize the Sustained Release Microparticles of Gefitinib.

Curr Drug Deliv 2018 12 26. Epub 2018 Dec 26.

Oriental College of Pharmacy and Research, Oriental University, Indore-453555, MP. India.

Gefitinib (GEF), the EGFR inhibitor, preferentially used in therapy of the non-small cell lung cancer suffers from the possibility of drug resistance with the present conventional delivery. GEF is presently marketed as tablets and has to be taken by the oral route in high doses of 250-500 mg per day. The drug has poor solubility in water which also affects both the bioavailability and onset of action. Read More

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http://dx.doi.org/10.2174/1567201816666181227114109DOI Listing
December 2018
6 Reads

Development and Characterization of Olanzapine Loaded Poly(lactide-co-glycolide) Microspheres for Depot Injection: In Vitro and In Vivo Release Profiles.

Curr Drug Deliv 2018 Dec 26. Epub 2018 Dec 26.

Department of Pharmacy, COMSATS University Islamabad, Lahore Campus 60000. Pakistan.

Purpose: The Purpose of this study was to develop a new PLGA based microsphere formulation aimed to release the olanzapine for the period of one month which will result in increased compliance.

Methods: Microspheres loaded with olanzapine were prepared using oil in water emulsion and solvent evaporation technique. The microspheres were characterized by surface morphology, shape, size, bulk density, encapsulation efficiency, and Fourier transform infrared spectrometry. Read More

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http://dx.doi.org/10.2174/1567201816666181227105930DOI Listing
December 2018
3 Reads

Preface.

Authors:
Xing-Jie Liang

Curr Drug Deliv 2019 ;16(1)

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http://dx.doi.org/10.2174/156720181601181102092244DOI Listing
January 2019
1 Read

Formulation and Characterization of Genistein-loaded Nanostructured Lipid Carriers: Pharmacokinetic, Biodistribution and In vitro Cytotoxicity Studies.

Curr Drug Deliv 2019 ;16(3):215-225

Indian Institute of Technology (Banaras Hindu University), Department of Pharmaceutical Engineering & Technology, Varanasi -221005 (U.P.), India.

Background: Genistein (Gen) is a naturally occurring soy isoflavonoid, possessing anticancer, antiproliferation & antioxidant-like properties. The disadvantage of poor solubility and less oral bioavailability restrict its use as a potential anticancer agent.

Objectives: The current work was focused on the formulation and characterization of the genistein loaded nanostructured lipid carriers that can entrap enough quantity of the drug which will provide sustained release of the drug for the treatment of ovarian cancer. Read More

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http://dx.doi.org/10.2174/1567201816666181120170137DOI Listing
January 2019
12 Reads

Lectins and Nanostructured Drug Delivery Systems.

Curr Drug Deliv 2019 ;16(3):268-269

Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Maringa, Brazil.

The advances and the impact of nanostructured systems on therapeutics constitute a constantly evolving reality. New strategies have been developed for drug delivery control and for directing these systems to the targeted site improving the therapy. In this commentary, the lectins are briefly reviewed; their fundamentals and the proposed applications as ligands in nanostructured drug delivery systems are discussed. Read More

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http://dx.doi.org/10.2174/1567201816666181122105548DOI Listing
January 2019
11 Reads

Sucrose acetate isobutyrate as an in situ-forming implant for sustained release of local anesthetics.

Curr Drug Deliv 2018 Nov 18. Epub 2018 Nov 18.

Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072. China.

In this study, an injectable sucrose acetate isobutyrate (SAIB) drug delivery system (SADS) was designed and fabricated for the sustained release of ropivacaine (RP) to prolong the duration local anesthesia. By mixing SAIB, RP, and N-methyl-2-pyrrolidone, the SADS was prepared in a sol state with low viscosity before injection. After subcutaneous injection, the pre-gel solution underwent gelation in situ to form a drug-released depot. Read More

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http://dx.doi.org/10.2174/1567201816666181119112952DOI Listing
November 2018
10 Reads

Label Free Ultrasmall Fluoromagnetic Ferrite-clusters for Targeted Cancer Imaging and Drug Delivery.

Curr Drug Deliv 2019 ;16(3):233-241

Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research & Education (CARE), Kelambakkam, Chennai 603 103, India.

Objective: The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and Magnetic Resonance (MR) cancer imaging.

Methods: The ultra-small manganese ferrite nanoclusters (PMNCs) with a diameter of 4 nm have a commendable effect on the longitudinal (T1) and transverse (T2) relaxation in MR imaging that was evident from the phantom and animal MRI.

Results: The calculated longitudinal molar relaxivity of nanoclusters was found to be 6. Read More

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http://www.eurekaselect.com/167465/article
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http://dx.doi.org/10.2174/1567201816666181119112410DOI Listing
January 2019
16 Reads
2.248 Impact Factor

Preparation, Characterization, and In Vitro pH-sensitivity Evaluation of Superparamagnetic Iron Oxide Nanoparticle- Misonidazole pH-sensitive Liposomes.

Curr Drug Deliv 2019 ;16(3):254-267

Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.

Background: The use of Misonidazole (MISO), the first and a potential hypoxic tumor cell radiosensitizer, has been limited by peripheral neurotoxicity, thus discouraging phase III clinical trials.

Objective: To develop a targeted drug delivery and tracing System with pH-sensitive liposomes (SpHLs) and Superparamagnetic Iron Oxide Nanoparticles (SPIONs) to counter MISO-related adverse effects and to enable tracing under magnetic resonance.

Methods: SPION-MISO-SpHLs were prepared by a reverse evaporation and freeze-thawing method. Read More

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http://dx.doi.org/10.2174/1567201816666181114124333DOI Listing
January 2019
11 Reads

Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.

Curr Drug Deliv 2019 ;16(3):226-232

Department of Pharmaceutical Sciences, USF College of Pharmacy, University of South Florida, Tampa, FL 33647, United States.

Background: Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer's Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related Macular Degeneration (AMD) is the leading cause of blindness in the developing world. Read More

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http://www.eurekaselect.com/166858/article
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http://dx.doi.org/10.2174/1567201815666181031163111DOI Listing
January 2019
4 Reads

Graphene Family of Nanomaterials: Reviewing Advanced Applications in Drug delivery and Medicine.

Curr Drug Deliv 2019 ;16(3):195-214

Defence Research Laboratory, Tezpur, India.

Graphene in nano form has proven to be one of the most remarkable materials. It has a single atom thick molecular structure and it possesses exceptional physical strength, electrical and electronic properties. Applications of the Graphene Family of Nanomaterials (GFNs) in different fields of therapy have emerged, including for targeted drug delivery in cancer, gene delivery, antimicrobial therapy, tissue engineering and more recently in more diseases including HIV. Read More

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http://dx.doi.org/10.2174/1567201815666181031162208DOI Listing
January 2019
3 Reads
2.250 Impact Factor

Facile Synthesis of Chitosan Based-(AMPS-co-AA) Semi-IPNs as a Potential Drug Carrier: Enzymatic Degradation, Cytotoxicity, and Preliminary Safety Evaluation.

Curr Drug Deliv 2019 ;16(3):242-253

Department of Pharmacy, COMSATS University, Islamabad (Abbottabad campus 22060), Pakistan.

Objective: The study describes the development of chitosan-based (AMPS-co-AA) semi-IPN hydrogels using free radical polymerization technique.

Methods: The resulting hydrogels were characterized using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), X-Ray diffraction (XRD), and Scanning Electron Microscopy (SEM). The successful crosslinking of chitosan, 2- Acrylamido-2-Methylpropane Sulfonic Acid (AMPS), and Acrylic Acid (AA) was confirmed by FT IR. Read More

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http://www.eurekaselect.com/166595/article
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http://dx.doi.org/10.2174/1567201815666181024152101DOI Listing
January 2019
8 Reads

Permeation Efficacy of a Transdermal Vehicle with Steroidal Hormones and Nonsteroidal Anti-inflammatory Agents as Model Drugs.

Curr Drug Deliv 2019 ;16(2):136-141

Ortofarma Laboratory, Matias Barbosa, Brazil.

Background: Transdermal delivery is an alternative route for the administration of drugs. However, it requires the development of vehicles that allow the drugs to cross the layers of the skin and reach the systemic circulation.

Objective: In this study, a new transdermal vehicle was evaluated using progesterone, estradiol, estradiol + estriol (Biest) and ketoprofen administered as model drugs. Read More

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http://dx.doi.org/10.2174/1567201815666181024141849DOI Listing
January 2019
2 Reads

Gemcitabine-loaded Folic Acid Tagged Liposomes: Improved Pharmacokinetic and Biodistribution Profile.

Curr Drug Deliv 2019 ;16(2):111-122

Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Odisha, India.

Background: Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer targeting. Read More

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http://dx.doi.org/10.2174/1567201815666181024112252DOI Listing
January 2019
11 Reads
2.248 Impact Factor

Delivery of Dry Powders to the Lungs: Influence of Particle Attributes from a Biological and Technological Point of View.

Curr Drug Deliv 2019 ;16(3):180-194

Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Dry powder inhalers are medical devices used to deliver powder formulations of active pharmaceutical ingredients via oral inhalation to the lungs. Drug particles, from a biological perspective, should reach the targeted site, dissolve and permeate through the epithelial cell layer in order to deliver a therapeutic effect. However, drug particle attributes that lead to a biological activity are not always consistent with the technical requirements necessary for formulation design. Read More

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http://dx.doi.org/10.2174/1567201815666181024143249DOI Listing
January 2019
3 Reads
2.250 Impact Factor

Current Updates on Bone Grafting Biomaterials and Recombinant Human Growth Factors Implanted Biotherapy for Spinal Fusion: A Review of Human Clinical Studies.

Curr Drug Deliv 2019 ;16(2):94-110

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia.

Background: Owing to their great promise in the spinal surgeries, bone graft substitutes have been widely investigated for their safety and clinical potential. By the current advances in the spinal surgery, an understanding of the precise biological mechanism of each bone graft substitute is mandatory for upholding the induction of solid spinal fusion.

Objective: The aim of the present review is to critically discuss various surgical implications and level of evidence of most commonly employed bone graft substitutes for spinal fusion. Read More

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http://dx.doi.org/10.2174/1567201815666181024142354DOI Listing
January 2019
6 Reads
2.250 Impact Factor

Utilization of Apatinib-Loaded Nanoparticles for the Treatment of Ocular Neovascularization.

Curr Drug Deliv 2019 ;16(2):153-163

Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, United States.

Background: The current treatment of ocular neovascularization requires frequent intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents that cause severe side effects.

Objective: The purpose of this study is to prepare and characterize a novel nanoscale delivery system of apatinib for ocular neovascularization.

Methods: The optimized formulation showed a particle size of 135. Read More

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http://dx.doi.org/10.2174/1567201815666181017095708DOI Listing
January 2019
10 Reads

The Superior Antitumor Effect of Self-Assembled Paclitaxel Nanofilaments for Lung Cancer Cells.

Curr Drug Deliv 2019 ;16(2):171-178

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.

Objectives: Paclitaxel (Ptx) has been regarded as one of the most effective chemotherapeutic drugs for lung cancers. Increasing studies focused on the nano-delivery system of Ptx due to its poor solubility and hypersensitivity. The aim of the recent study was to investigate the antitumor effects of self-assembled Ptx nano-filaments for lung cancer cells. Read More

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http://www.eurekaselect.com/166328/article
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http://dx.doi.org/10.2174/1567201815666181017094003DOI Listing
January 2019
12 Reads

Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array.

Curr Drug Deliv 2019 ;16(2):164-170

Advanced Research Institute of Multidisciplinary Science, School of Life Science, Key Laboratory of Molecular Medicine and Biotheranotics, Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing, 100081, China.

Background: Delivery of foreign cargoes into cells is of great value for bioengineering research and therapeutic applications.

Objective: In this study, we proposed and established a carrier-free gene delivery platform utilizing staggered herringbone channel and silicon nanoneedle array, to achieve high-throughput in vitro gene transfection.

Methods: With this microchip, fluidic micro vortices could be induced by the staggered-herringboneshaped grooves within the channel, which increased the contact frequency of the cells with the channel substrate. Read More

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http://dx.doi.org/10.2174/1567201815666181017095044DOI Listing
January 2019
12 Reads

Formulation and Evaluation of Neuroactive Drug Loaded Chitosan Nanoparticle for Nose to Brain Delivery: In-vitro Characterization and In-vivo Behavior Study.

Curr Drug Deliv 2019 ;16(2):123-135

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed University), M.B. Road, New Delhi- 110062, India.

Background: The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nanoparticle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via the nasal route.

Methods: The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study. Read More

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http://www.eurekaselect.com/166158/article
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http://dx.doi.org/10.2174/1567201815666181011121750DOI Listing
January 2019
5 Reads
2.250 Impact Factor

Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for Silybin Delivery: Formulation, Characterization, and In vitro Evaluation.

Curr Drug Deliv 2019 ;16(2):142-152

Department of Chemistry, University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, (FI), Italy.

Background: Silybin (Sb) is the major flavolignan of the extract of Silybum marianum. It is used for the treatment of various acute and chronic liver toxicities, inflammation, fibrosis and oxidative stress. Many studies indicate that Sb is also active against different carcinomas and it has been very recently proposed to be beneficial in type 2 diabetes patients. Read More

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http://dx.doi.org/10.2174/1567201815666181008153602DOI Listing
January 2019
6 Reads

Nose to Brain Delivery of Galantamine Loaded Nanoparticles: In-vivo Pharmacodynamic and Biochemical Study in Mice.

Curr Drug Deliv 2019 ;16(1):51-58

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India.

Background: Presence of blood brain barrier is one of the major hurdle in drug delivery to brain for the treatment of neurological diseases. Alternative and more effective drug delivery approaches have been investigated for the drug targeting to brain in therapeutic range.

Objective: The present investigation was carried out to improve the galantamine bioavailability in brain by intranasal drug delivery through thiolated chitosan nanoparticles and compared to nasal and oral delivery of its solution using pharmacodynamic activity as well as biochemical estimation. Read More

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http://www.eurekaselect.com/165932/article
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http://dx.doi.org/10.2174/1567201815666181004094707DOI Listing
January 2019
4 Reads
2.250 Impact Factor

Development of Biodegradable Injectable In situ Forming Implants for Sustained Release of Lornoxicam.

Curr Drug Deliv 2019 ;16(1):66-78

Department of Pharmaceutics, Anand Pharmacy College, Anand- 388 001, Gujarat, India.

Objective: The focus of this study was to develop in situ injectable implants of Lornoxicam which could provide sustained drug release.

Methods: Biodegradable in situ injectable implants were prepared by polymer precipitation method using polylactide-co-glycolide (PLGA). An optimized formulation was obtained on the basis of drug entrapment efficiency, gelling behavior and in vitro drug release. Read More

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http://dx.doi.org/10.2174/1567201815666180927155710DOI Listing
January 2019
11 Reads

Controlled Release of Doxycycline by Magnetized Microporous MIL53(Fe); Focus on Magnetization and Drug Loading.

Curr Drug Deliv 2019 ;16(1):42-50

Department of Chemistry, Shahreza Branch, Islamic Azad University, Shahreza, Iran P.O. Box 311-86145, Shahreza, Iran.

Background: In this research, MIL-53(Fe) was magnetized and the performance of the magnetized material as a drug delivery system for doxycycline was studied.

Objectives: The experiments were designed to load the magnetic delivery compounds with different amount of the drug.

Methods: The in vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content into saline buffered fluid (SBF, pH=7. Read More

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http://dx.doi.org/10.2174/1567201815666180926120525DOI Listing
January 2019
3 Reads

A New Therapeutic Approach for Brain Delivery of Epigallocatechin Gallate: Development and Characterization Studies.

Curr Drug Deliv 2019 ;16(1):59-65

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160012, India.

Background: Blood-brain permeability is the primary concern when dealing with the biodistribution of drugs to the brain in neurological diseases.

Objective: The purpose of the study is to develop the nanoformulation of Epigallocatechin gallate (EGCG) in order to improve its bioavailability and penetration into the brain.

Methods: EGCG loaded Solid Lipid Nanoparticles (SLNs) have been developed using microemulsification method and pharmacological assessments were performed. Read More

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http://dx.doi.org/10.2174/1567201815666180926121104DOI Listing
January 2019
3 Reads
2.250 Impact Factor

Improved In vivo Effect of Chrysin as an Absorption Enhancer Via the Preparation of Ternary Solid Dispersion with Brij®L4 and Aminoclay.

Curr Drug Deliv 2019 ;16(1):86-92

College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang, Korea.

Background: Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux.

Objective: This study aimed to develop an effective oral formulation of chrysin to improve its in vivo effect as an absorption enhancer. Read More

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http://dx.doi.org/10.2174/1567201815666180924151458DOI Listing
January 2019
4 Reads

Breaking the Barrier of Cancer Through Liposome Loaded with Phytochemicals.

Authors:
Tapan Kumar Giri

Curr Drug Deliv 2019 ;16(1):3-17

NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata Group of Institutions, 124 BL Saha Road, Kolkata-700053, West Bengal, India.

Currently, the most important cause of death is cancer. To treat the cancer there are a number of drugs existing in the market but no drug is found to be completely safe and effective. The toxicity of the drugs is the key problem in the cancer chemotherapy. Read More

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http://dx.doi.org/10.2174/1567201815666180918112139DOI Listing
January 2019
3 Reads

Aspects of Nanomaterials in Wound Healing.

Curr Drug Deliv 2019 ;16(1):26-41

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786 004, Assam, India.

Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, influencing the cost of treatment. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diversified categories of wounds such as acute and chronic wounds. However, nanotechnology-based diagnostics and treatments have achieved a new horizon in the arena of wound care due to its ability to deliver a plethora of therapeutics into the target site, and to target the complexity of the normal wound-healing process, cell type specificity, and plethora of regulating molecules as well as pathophysiology of chronic wounds. Read More

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http://dx.doi.org/10.2174/1567201815666180918110134DOI Listing
January 2019
4 Reads
2.250 Impact Factor

Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin.

Curr Drug Deliv 2019 ;16(1):79-85

Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nanofibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants.

Methods: Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the preparation of the fiber matrices through electrospinning. The in vitro modified release profile of MLT from the fabricated matrices in gastrointestinal-like fluids was studied. Read More

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http://dx.doi.org/10.2174/1567201815666180914095701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340153PMC
January 2019
3 Reads

Insights on the Use of Nanocarriers for Acne Alleviation.

Curr Drug Deliv 2019 ;16(1):18-25

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is neither limited to a specific age, nor to a certain gender, it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successful, but when administered as such, they showed many adverse effects, starting from itching to skin dryness and inflammation. Read More

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http://www.eurekaselect.com/165428/article
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http://dx.doi.org/10.2174/1567201815666180913144145DOI Listing
January 2019
26 Reads

In Vitro and In Vivo Evaluation of Lidocaine Hydrochloride-loaded Injectable Poly(Lactic-co-glycolic Acid) Implants.

Curr Drug Deliv 2018 ;15(10):1411-1416

Department of Anesthesiology, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Effective postoperative pain control is essential for the recovery of surgical patients. However, long-term analgesia can seldom be achieved with the existing medications. The injectable implants prepared by biodegradable polyesters can be conveniently used during the surgery and slowly release analgesics near the operative incision for a long period. Read More

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http://dx.doi.org/10.2174/1567201815666180912123137DOI Listing
January 2018
4 Reads

On the Structure and Transdermal Profile of Liquid Crystals Based on Phytantriol.

Curr Drug Deliv 2018 ;15(10):1439-1448

School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.

Background: There has been a growing concern in transdermal drug technology over the past several decades. As a novel transdermal delivery system, Lyotropic liquid crystals (LLC) still face challenges such as drug loading, limited drug permeation and instability of systems. LLC system is so sensitive that a very subtle change in composition may induce a phase transformation or conversion of spatial configuration, and result in a diverse percutaneous delivery subsequently. Read More

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http://dx.doi.org/10.2174/1567201815666180910142516DOI Listing
January 2018
13 Reads
2.248 Impact Factor

Recent Advances in Chiral Separation of Antihistamine Drugs: Analytical and Bioanalytical Methods.

Curr Drug Deliv 2018 ;15(10):1393-1410

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru, Karnataka, India.

Chirality is now a key area in the field of research. Researchers are well versed with analytical separations but at the same time, they are unaware of the growth in the field of chiral separation. According to the United States Food and Drug Administration (US FDA) guidelines, it is mandatory to separate chiral drugs before they are marketed. Read More

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http://dx.doi.org/10.2174/1567201815666180830100015DOI Listing
January 2018
3 Reads

Anesthetic Molecule Interaction of Noble Gases with Proteins and Lipids and their Effect: A Review.

Curr Drug Deliv 2018 ;15(10):1381-1392

Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.

Surgical operations are impossible without administering proper analgesia. Advancement in the field of anesthesia has invariably resulted in the accomplishment of all surgical processes without any inconvenience. Admittedly, the use of noble gas is on the decline. Read More

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http://www.eurekaselect.com/164753/article
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http://dx.doi.org/10.2174/1567201815666180820101255DOI Listing
January 2018
11 Reads
2.248 Impact Factor

Solid Dispersion of Hesperetin Co-crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats.

Curr Drug Deliv 2018 ;15(10):1426-1438

Department of Pharmacology & Toxicology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability.

Objectives: This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP.

Methods: Co-crystals were prepared using citric acid, tartaric acid, caffeine and isonicotinamide (INM) using two methods of solvent evaporation and co-grinding. Read More

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http://dx.doi.org/10.2174/1567201815666180730141556DOI Listing
January 2018
5 Reads

Topical Botulinum Toxin: A Non-invasive Way for Treatment of Muscle Disorders.

Curr Drug Deliv 2018 ;15(10):1375-1380

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Botulinum neurotoxin type A (BoNT/A) is a toxin that inhibits the release of stimulatory neurotransmitter (acetylcholine) at the neuromuscular synapses. In recent years, many patients with muscle contraction disorders have greatly benefited from the therapeutic ability of this biological drug. On the other hand, the injection of this bio drug is accompanied by some side effects such as irritation, bruising, inflammation, pain, bleeding at the site of injection. Read More

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http://dx.doi.org/10.2174/1567201815666180730140704DOI Listing
January 2018
13 Reads

The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine.

Curr Drug Deliv 2018 ;15(10):1449-1458

Department of Soil and Water Systems, University of Idaho, Moscow, Idaho, ID 83844-2339, United States.

Background: It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. Read More

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http://dx.doi.org/10.2174/1567201815666180730125941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340158PMC
January 2018
4 Reads

Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes.

Curr Drug Deliv 2018 ;15(10):1417-1425

Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.

Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects.

Objective: A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylalanine (BPA) was designed and synthesized, for the first time, by using 2, 2'-dipyridyl (L1) and 4, 4'-diaminobibenzyl (L2) ligands. Characterization of the synthesized complexes was achieved by using 1H-NMR, IR, MS and elemental analyses. Read More

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http://dx.doi.org/10.2174/1567201815666180727145724DOI Listing
January 2018
4 Reads

Cell Surface Nucleolin as a Promising Receptor for Effective AS1411 Aptamer-Mediated Targeted Drug Delivery into Cancer Cells.

Curr Drug Deliv 2018 ;15(9):1323-1329

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery.

Objectives: In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly lacticco- glycolic acid (PLGA)-based nanoparticles (NPs). Then, the targeting ability of anti nucleolin AS1411 aptamer-targeted Dox-encapsulated PLGA-based NPs (AS1411-NPs) was investigated in high nucleolin-expressing C26 colon carcinoma and rat C6 glioma cell lines compared with low nucleolinexpressing mouse L929 cell line. Read More

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http://www.eurekaselect.com/164017/article
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http://dx.doi.org/10.2174/1567201815666180724104451DOI Listing
December 2018
4 Reads