698 results match your criteria Current Diabetes Reviews[Journal]


The Etiology and Treatment of LADA: An Update.

Authors:
Valdemar Grill

Curr Diabetes Rev 2019 ;15(3):171

Department of Clinical and Molecular Medicine Norwegian University of Science and Technology 7006 Trondheim, Norway.

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http://dx.doi.org/10.2174/157339981503190401141110DOI Listing
January 2019

Streptozotocin-Induced Diabetes Mellitus in Neonatal Rats: An insight into its applications to Induce Diabetic Complications.

Curr Diabetes Rev 2019 Apr 11. Epub 2019 Apr 11.

Institute of Pharmacy, Department of Pharmcology, Nirma University, Ahmedabad, Gujarat. India.

Background: Diabetic complications are the major contributor in mortality of diabetic patients despite controlling blood glucose level. In the journey of new drug discovery, animal models have to play a major role. A large number of chemical-induced and genetically modified animal models have been investigated to induce diabetic complications but none of them was found to be mimicking the pathophysiology of the human. Read More

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http://dx.doi.org/10.2174/1573399815666190411115829DOI Listing

Study of Possible Relation between Fasting plasma Glucagon ,Gestational Diabetes and Development of Type 2 DM.

Curr Diabetes Rev 2019 Apr 5. Epub 2019 Apr 5.

Clinical Pathology Department, Ain Shams University Hospitals, Cairo. Egypt.

Background And Aims: Women who develop GDM (gestational diabetes mellitus) have a relative insulin secretion deficiency, the severity of which may be predictive for later development of diabetes. The study aimed to investigate the role of fasting plasma glucagon in prediction of later development of diabetes in pregnant ladies with GDM.

Materials And Methods: study was conducted on 150 pregnant ladies with GDM after giving an informed oral and written consents approved by research ethical committee according to declaration of Helsinki, The study was conducted on two phases, first during pregnancy and the second was six months post-partum, as we measured fasting plasma glucagon before and after delivery together with fasting and 2 hour post-prandial plasma sugar, the finding suggested that glucagon levels significantly increased after delivery in the majority 14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared to 6/20 (30%) in patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) of non DM women as the median glucagon levels were (80,76, 55) respectively and also there was high statistical difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic ladies (p ≤ 0. Read More

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http://dx.doi.org/10.2174/1573399815666190405171907DOI Listing
April 2019
1 Read

A Comparison of biomarkers in assessment of glycemic control in diabetes: Reviewing the Evidence.

Curr Diabetes Rev 2019 04 8. Epub 2019 Apr 8.

Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdul Aziz University for Health Sciences, National Guard Health Affairs. Jeddah. Saudi Arabia.

Background: Diabetes mellitus (DM) is a chronic life-long progressive multisystem heterogeneous metabolic disorder with complex pathogenesis.

Introduction: Hyperglycemia is not only one of the classical signs of DM, but it also serves as the pivotal prerequisite for the diagnosis of the disease. However, with advancement in the field of analytical biochemistry, a number of alternative and specific biomarkers have been discovered which can be used for the better diagnosis of the DM. Read More

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http://dx.doi.org/10.2174/1389557519666190408197922DOI Listing

Efficacy and safety of Dipeptidyl Peptidase-4 Inhibitors in kidney transplant recipients with Post-transplant diabetes mellitus (PTDM)-a systematic review and Meta-Analysis.

Curr Diabetes Rev 2019 Mar 21. Epub 2019 Mar 21.

Department of Renal medicine -Kasr Alainy Hospitals-Cairo University hospitals. Egypt.

Background: Kidney transplant recipients may develop post-transplant diabetes mellitus (PTDM). Dipeptidyl peptidase 4(DPP-4) inhibitors are evolving agents in the management of patients with diabetes mellitus.

Aim: To synthesize evidence for the efficacy and safety of DPP-4 inhibitors in the management of post-transplant diabetes mellitus (PTDM) in renal transplant recipients. Read More

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http://dx.doi.org/10.2174/1573399815666190321144310DOI Listing

ADIE - nursing interventions of diabetic foot ulcer: An integrative review of the literature.

Curr Diabetes Rev 2019 03 7. Epub 2019 Mar 7.

Ramathibodi School of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background And Aims: Diabetic foot ulcer is recognized as the consequence of peripheral neuropathy and peripheral arterial disease amid individuals with diabetes. As is well known, this situation still remains a crucial problem in nursing practice. Available studies describing an algorithm of inter-related nursing interventions concerned with diabetic foot ulcers are limited. Read More

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http://dx.doi.org/10.2174/1573399815666190307164119DOI Listing
March 2019
3 Reads

Review of Diabetic Polyneuropathy: Pathogenesis, Diagnosis and Management According to the Consensus of Egyptian Experts.

Curr Diabetes Rev 2019 Feb 26. Epub 2019 Feb 26.

Faculty of Medicine, Alexandria University. Egypt.

Diabetic polyneuropathy (DPN) is a complex and multifactorial entity in which various factors besides hyperglycemia play an important role. Symptoms of DPN are sensory, motor or autonomic. Intensive research proved that oxidative stress is the common denominator for the four major destructive pathways of hyperglycemia including increased hexosamine pathway flux, activation of Protein kinase-C (PKC) pathway, increased Advanced Glycated End-products (AGEs) formation, and increased Polyol Pathway flux. Read More

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http://dx.doi.org/10.2174/1573399815666190226150402DOI Listing
February 2019
8 Reads

Clinical Predictors of Diabetic Retinopathy Progression; A Systematic Review.

Curr Diabetes Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Faculty of Medicine, Taif University, Taif. Saudi Arabia.

Objective: The study aims to review the published clinical predictors of Diabetic Retinopathy Progression and discuss their level of clinical significance.

Methods: The data for systematic review has been gathered from the studies that were searched through scholarly platforms and several libraries. These studies discussed the clinical predictors of Diabetic Retinopathy (DR) progression. Read More

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http://dx.doi.org/10.2174/1573399815666190215120435DOI Listing
February 2019
1 Read

Sodium intake, circulating microvesicles and cardiovascular outcomes in type 2 diabetes.

Curr Diabetes Rev 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Austin Health, Heidelberg, Victoria. Austria.

There is ongoing debate surrounding the complex relationship between dietary sodium intake and cardiovascular morbidity and mortality. The existing literature consists largely of observational studies that have demonstrated positive, negative, U-/J-shaped or unclear associations between sodium intake and cardiovascular outcomes. Our group and others have previously demonstrated an inverse relationship between dietary sodium intake and cardiovascular outcomes in people with type 2 diabetes. Read More

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http://dx.doi.org/10.2174/1573399815666190212120822DOI Listing
February 2019

Comparing the Efficacy of Supervised and Unsupervised Exercise Training on Glycaemic Control in Type 2 Diabetes: A Systematic Review.

Curr Diabetes Rev 2019 Feb 12. Epub 2019 Feb 12.

School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland. Australia.

Background: Exercise training is vital for glycaemic control in patients with type 2 diabetes mellitus (T2D). While the positive effects of supervised exercise training are well established, unsupervised training may offer an alternative and more sustainable means of realising the benefits of exercise away from a resource-heavy supervised setting.

Objective: To evaluate the available literature and compare the efficacy of supervised and unsupervised exercise training programs on glycaemic control in patients with T2D. Read More

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http://dx.doi.org/10.2174/1573399815666190212120404DOI Listing
February 2019

Comparison Of Thermal Foot Maps Between Diabetic Patients With Neuropathic, Vascular, Neurovascular, And No Complications.

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Department of Nursing, University of Extremadura, Avda. Virgen del Puerto s/n. Spain.

Background: Diabetes mellitus is a public health problem worldwide. The diabetic foot has a degenerate vascular structure, and its patients present neurological problems, which require the earliest possible identification.

Introduction: The objective of the research was to use infrared thermography to analyze the temperature difference of the feet of users with diabetes mellitus with neuropathy, vasculopathy, neurovascular disease, or none of them, segmenting the sole of the foot in four areas for the study. Read More

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http://dx.doi.org/10.2174/1573399815666190206160711DOI Listing
February 2019
2 Reads

Prepubertal IGF-1 and possible relation with physical features of growth and Type 1 Diabetes Mellitus.

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Internal Medicine Department, Endocrinology unit,Ain Shams University hospitals,Cairo. Egypt.

Introduction: T1DM is considered the most common chronic metabolic autoimmune disorder in childhood and adolescence as well as in early adulthood. It appears frequently during 12-13 years of age with distinctive features like immune-mediated chronic damage of pancreatic β-cells, leading eventually to partial, or mostly, absolute insulin deficiency. Insulin-like growth factor 1 (IGF-1) is a polypeptide consisting of 70 amino acids with insulin-like chemical structure. Read More

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http://dx.doi.org/10.2174/1573399815666190206161230DOI Listing
February 2019
4 Reads

The Gut Microbiome, Lactobacillus Acidophilus; Relation with Type 2 Diabetes Mellitus.

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Internal Medicine, National Research Center, Cairo11566. Egypt.

Background: Symbiotic interactions of microorganisms are widespread in nature, and support fundamentally important processes linking health and disease to the bacterial ecology. Intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. It participates in the development of the postnatal immune system as well as oral tolerance and immunity. Read More

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http://dx.doi.org/10.2174/1573399815666190206162143DOI Listing
February 2019
33 Reads

Coagulopathy in Type 2 Diabetes Mellitus: pathological mechanisms and the role of Factor XIII-A single nucleotide polymorphisms.

Curr Diabetes Rev 2019 Jan 29. Epub 2019 Jan 29.

Department of Physiology, Faculty of Health Sciences, University of Pretoria. South Africa.

The prevalence of type 2 diabetes mellitus (T2DM) has quadrupled within three decades since 1980 affecting 422 million adults in 2016. It remains one of the most common non-communicable chronic diseases and underlying risk factor for cardiovascular diseases worldwide. There are different underlying mechanisms that play a role in the development of pathologies associated with the disease such as hyperglycaemia, oxidative stress, obesity, inflammation and hypercoagulation. Read More

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http://dx.doi.org/10.2174/1573399815666190130113328DOI Listing
January 2019
3 Reads

Growth of diabetes research in United Arab Emirates: current and future perspectives.

Curr Diabetes Rev 2019 Jan 31. Epub 2019 Jan 31.

Basic Medical Science Department College of Medicine, University of Sharjah, Sharjah. United Arab Emirates.

Background: Diabetes mellitus (DM) is one of the most prevalent metabolic diseases in the UAE. During the last two decades, the United Arab Emirates (UAE) has experienced tremendous development in all fields including DM research. The present study sheds light on the growth in DM research in UAE and represents a guide for DM researchers to create more focused future directions in DM research. Read More

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http://dx.doi.org/10.2174/1573399815666190201114408DOI Listing
January 2019
10 Reads

Intron-specific Single Nucleotide Polymorphisms of Fat Mass and Obesity-Associated Gene in obese and overweight individuals of the Indian adult population- A pilot study.

Curr Diabetes Rev 2018 Nov 26. Epub 2018 Nov 26.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore. India.

Background: The Fat mass and obesity-associated gene (FTO) and its involvement in weight gain and obesity is well-known. However, there are no reports published on Indian population regarding the relation between single nucleotide polymorphisms (SNPs) in its intronic region and obesity. The aim of this pilot study was to evaluate the frequency and association of SNPs in intron-1 of the FTO gene in obese and overweight Indian adults. Read More

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http://dx.doi.org/10.2174/2542591901666181126144449DOI Listing
November 2018

Validity of visceral fat area measurement by bioelectrical impedance analysis in Japanese obese individuals.

Curr Diabetes Rev 2019 Jan 27. Epub 2019 Jan 27.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba. Japan.

Obesity management is a critical global issue. It is essential to evaluate visceral adiposity which is associated with metabolic syndrome and cardiovascular disease. This study aims at precisely evaluating the necessity of visceral adipose tissue in obesity management. Read More

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http://dx.doi.org/10.2174/1573399815666190128113657DOI Listing
January 2019

BILATERAL INTERRELATIONSHIP OF DIABETES AND PERIODONTIUM.

Curr Diabetes Rev 2019 Jan 15. Epub 2019 Jan 15.

BAPUJI DENTAL COLLEGE AND HOSPITAL,PERIODONTICS. India.

Periodontitis is a chronic inflammatory disease characterised by destruction of the supporting structures of the teeth which is a common cause of tooth mortality in all individuals throughout the world. Diabetes is a group of metabolic dysregulation, primarily of carbohydrate metabolism, characterized by hyperglycemia that results from defects in insulin secretion, impaired insulin action, or both. Systematic reviews and meta-analysis have shown that the prevalance of periodontitis is increased in diabetic patients. Read More

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http://dx.doi.org/10.2174/1573399815666190115144534DOI Listing
January 2019
4 Reads

Pathophysiological mechanisms linking type 2 diabetes and dementia: Review of evidence from clinical, translational and epidemiological research.

Curr Diabetes Rev 2019 01 15. Epub 2019 Jan 15.

Department of Endocrinolgy and Metabolism. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico.

Background: Type 2 diabetes represents an increasing health burden world-wide and its prevalence in particularly higher in elderly population. Consistent epidemiological evidence suggests an increased risk of dementia associated to type 2 diabetes; the mechanisms underlying these associations, however, remain unclear.

Objective: To review epidemiological, clinical and pre-clinical data that weigh on pathophysiological links, mechanisms of disease and associations between type 2 diabetes and dementia to identify areas of opportunity for future research. Read More

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http://www.eurekaselect.com/169013/article
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http://dx.doi.org/10.2174/1573399815666190129155654DOI Listing
January 2019
16 Reads

T-wave area dispersion in coronary artery bypass grafting is indicative for increased risk of adverse events in diabetics.

Curr Diabetes Rev 2019 Jan 15. Epub 2019 Jan 15.

Acibadem City Clinic Cardiovascular Center - University Hospital, Sofia. Bulgaria.

Problems in measuring the QT-dispersion are associated mostly with inaccurate location of the T-wave end. The complications are: (i) in methodology due to various definition for Tend, (ii) in automatic measurements, due to low amplitude of T-wave, presence of U-wave and noise, and (iii) in manual measurements, due to lack of repeatability in the results, and involuntary subjectivism, when the QT-dispersion is measured by a person familiar with the ultimate goal of the study. New ECG repolarization parameter, 'T-wave area dispersion' (TWAD), has been defined by Kenttä et al. Read More

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http://dx.doi.org/10.2174/1573399815666190115150321DOI Listing
January 2019
12 Reads

The impact of pregnancy and parity on Type 1 diabetes complications.

Curr Diabetes Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Diseases and Diabetology of the Medical University of Lodz, Pomorska str. 251, 92-213 Lodz. Poland.

Background: Potential influence of pregnancy and parity on the risk of chronic diabetic complications is a matter of great concern and constant discussion. This aspect seems relevant and should be the subject of thorough discussion with the woman planning childbirth.

Introduction: Current data concerning the impact of pregnancy and parity covers primarily retinopathy and nephropathy, while the aspects of neuropathy and macrovascular complications are unsatisfactorily documented. Read More

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http://dx.doi.org/10.2174/1573399815666190115143538DOI Listing
January 2019
20 Reads

Type-3c Diabetes Mellitus, Diabetes of Exocrine Pancreas - An Update.

Curr Diabetes Rev 2019 Jan 15. Epub 2019 Jan 15.

School of Pharmacy, Taylor's University, 1, Jalan Taylors, 47500 Subang Jaya, Selangor. Malaysia.

Background: The incidence of diabetes is increasing steeply; the number of diabetics has doubled over the past three decades. Surprisingly, the knowledge of type 3c diabetes mellitus (T3cDM) is still unclear to the researchers, scientist and medical practitioners, leading towards erroneous diagnosis, which is sometimes misdiagnosed as type 1 diabetes mellitus (T1DM), or more frequently type 2 diabetes mellitus (T2DM). This review is aimed to outline recent information on the etiology, pathophysiology, diagnostic procedures, and therapeutic management of T3cDM patients. Read More

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http://dx.doi.org/10.2174/1573399815666190115145702DOI Listing
January 2019
20 Reads

Preface.

Authors:
Norman E Cameron

Curr Diabetes Rev 2019 ;15(1)

University of Aberdeen Aberdeen, Scotland, United Kingdom.

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http://dx.doi.org/10.2174/157339981501181211091821DOI Listing
April 2019
1 Read

A Review of Type 2 Diabetes Mellitus Predisposing Genes.

Curr Diabetes Rev 2018 Dec 4. Epub 2018 Dec 4.

Department of Cell Biology and Genetics, University of Lagos. Nigeria.

Introduction: Scientists are considering the possibility of treating diabetes mellitus (DM) using a personalized approach in which various forms of the diseases will be treated based on the causal gene and its pathogenesis. To this end, scientists have identified mutations in certain genes as probable causes of Type 2 diabetes mellitus (T2DM) with diverse mechanisms.

Aim: This review was aimed at articulating already identified T2DM genes with their mechanisms of action and phenotypic presentations for the awareness of all stakeholders. Read More

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http://dx.doi.org/10.2174/1573399815666181204145806DOI Listing
December 2018
1 Read

The Metformin Paradox.

Curr Diabetes Rev 2018 Nov 19. Epub 2018 Nov 19.

Department of Obstetrics and Gynecology, Onze Lieve Vrouwe Gasthuis, Amsterdam. Netherlands.

Introduction: The Diabetes Prevention Program study results indicated that metformin therapy was not as beneficial as a lifestyle modification for delaying the development of type 2 diabetes in individuals at high risk of the disease. A key feature in the etiology of type 2 diabetes mellitus, which appears in the prediabetic phase, is a significant deficiency, compared to healthy controls, in highly flexible poly-cis-unsaturated fatty acyl chains in membrane phospholipids. This deficiency lowers membrane flexibility, which in turn, reduces the amount of all functional Class I glucose transporters, and thereby reduces glucose-mediated ATP production. Read More

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http://dx.doi.org/10.2174/1573399814666181119145750DOI Listing
November 2018
20 Reads

A Narrative Review of Diabetes Group Visits in Low-Income and Underserved Settings.

Curr Diabetes Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Medicine, Baylor College of Medicine, 1504 Taub Loop, 2 RM-81-001 a-f. BCM 285, Houston, TX. United States.

Background: Prior studies have supported the efficacy of diabetes group visits. However, the benefit of diabetes group visits for low-income and underserved individuals is not clear. The purpose of this study was to conduct a narrative review in order to clarify the efficacy of diabetes group visits in low-income and underserved settings. Read More

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http://dx.doi.org/10.2174/1573399814666181112145910DOI Listing
November 2018
17 Reads

The relationship between vitamin D deficiency and insulin resistance in pregnant women with gestational diabetes.

Curr Diabetes Rev 2018 Nov 1. Epub 2018 Nov 1.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Diabetes Mellitus is one of the most common medical disorders in pregnancy. The possibility of vitamin D deficiency as a pathogenesis for impaired glucose tolerance testes shows a probable role of vitamin D in insulin secretion and reduction of insulin resistance. This study was assigned to evaluate relation between serum vitamin D level and insulin resistance in gestational diabetes mellitus(GDM). Read More

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http://dx.doi.org/10.2174/1573399814666181102100816DOI Listing
November 2018
2 Reads

A perspective to the correlation between Brain insulin resistance and Alzheimer: Medicinal Chemistry approach.

Curr Diabetes Rev 2018 10 31. Epub 2018 Oct 31.

Amirkabir University of Technology, Biomaterial Group, Department of Biomedical Engineering. Iran.

Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding that biology and chemistry of each predicament, nevertheless regardless of T2DM and ADRDs are actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable approach from the Medicinal Chemistry concepts. Read More

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http://dx.doi.org/10.2174/1573399814666181031154817DOI Listing
October 2018
3 Reads

Nutraceuticals and diet-based phytochemicals in type 2 diabetes mellitus: from whole food to components with defined roles and mechanisms.

Curr Diabetes Rev 2018 Oct 30. Epub 2018 Oct 30.

Behavioural Neuroscience/Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State. Nigeria.

Background: Over the past decades, the development and use of an array of prescription medications has considerably improved the clinical management of type 2 diabetes mellitus and the quality of life of patients. However, as our knowledge of the associated risk factors and approaches to its management increases, the increasing roles of diet and the composition of the diet in the aetiology and successful management of diabetes mellitus are being illuminated. Presently, a lot of attention is being given to nutraceuticals and certain phytochemicals that are integral parts of the human diet. Read More

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http://dx.doi.org/10.2174/1573399814666181031103930DOI Listing
October 2018
4 Reads

Pattern and Correlates of Hypomagnesemia Among Subset of Diabetes Mellitus.

Curr Diabetes Rev 2018 Oct 25. Epub 2018 Oct 25.

University of Kufa, Faculty of Pharmacy, Department of Clinical Pharmacy. Iraq.

Background: Nowadays, there is an accumulated data about the relation between hypomagnesemia (low Serum Mg level < 0.7 mmol/l) and diabetes.

Objective: In this study, we aimed to determine the prevalence of hypomagnesemia in a carefully diagnosed diabetes patients and to show how some factors could contribute to the prevalence of low serum Mg level among the population under study. Read More

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http://dx.doi.org/10.2174/1573399814666181026095236DOI Listing
October 2018
31 Reads

From Endothelial Dysfunction to Arterial Stiffness in Diabetes Mellitus.

Curr Diabetes Rev 2018 Oct 17. Epub 2018 Oct 17.

Vascular Function Research Laboratory. Fundación Cardioinfantil-Instituto de Cardiología, Bogotá. Colombia.

Prevalence of diabetes mellitus has increased drastically over time, especially in more populous countries such as the United States, India, and China. Patients with diabetes have an increased risk of major cardiovascular events such as acute myocardial infarction, cerebrovascular disease, and peripheral vascular disease. Arterial stiffness is a process related to aging and vascular, metabolic, cellular and physiological deterioration. Read More

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http://dx.doi.org/10.2174/1573399814666181017120415DOI Listing
October 2018
3 Reads

A Tale of Two Eras: Mining Big Data from Electronic Health Records to Determine Limb Salvage Rates with Podiatry.

Curr Diabetes Rev 2018 Oct 16. Epub 2018 Oct 16.

Michigan Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes. Domino's Farms (Lobby C, Suite 1300) 24 Frank Lloyd Wright Drive Ann Arbor, Michigan 48106. United States.

Aims/hypothesis: Diabetes foot complications remain very prevalent in US and worldwide, and a major risk for devastating amputations. We evaluated the impact of establishing a fully integrated and specialized Podiatry service into a large tertiary academic health system to implement structured and targeted preventative foot care on limb salvage rates.

Methods: Cross-sectional cohorts' data mining analysis of all encounters for diabetes and any foot complications between 2000-2005 and 2010-2015, preceding and after full implementation of podiatry service, respectively. Read More

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http://dx.doi.org/10.2174/1573399814666181017104818DOI Listing
October 2018
3 Reads

Molecular and pathophysiological mechanisms of diabetic retinopathy in relation to adhesion molecules.

Curr Diabetes Rev 2018 Oct 16. Epub 2018 Oct 16.

Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh. Saudi Arabia.

Diabetic retinopathy (DR) is considered as most common microvascular complication of diabetes affected by one in three people who are suffered for diabetes. Several pathophysiological mechanisms and adhesion molecules may play an etiologic role in the development of diabetes and its complications. The adhesion molecules located on both leucocytes and endothelial cells and considered as important molecules which can assessed the endothelial function. Read More

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http://www.eurekaselect.com/166334/article
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http://dx.doi.org/10.2174/1573399814666181017103844DOI Listing
October 2018
19 Reads

Correlation of serum magnesium with insulin resistance in North Indian adult population.

Curr Diabetes Rev 2018 Oct 16. Epub 2018 Oct 16.

Department of Physiology, King Georges Medical University, Lucknow. India.

Background: Globalization has lead to such lifestyle changes which have produced increase in incidence and prevalence of Type 2 Diabetes Mellitus (T2DM). Magnesium is found to have some role in glucose metabolism. The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults. Read More

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http://dx.doi.org/10.2174/1573399814666181016164432DOI Listing
October 2018
5 Reads

Metabolic effects of metformin in humans.

Curr Diabetes Rev 2018 Oct 9. Epub 2018 Oct 9.

Internal Medicine Department Hospital General Juan Cardona c/ Pardo Bazan s/n 15406 Ferrol. Spain.

Background: both insulin deficiency and insulin resistance due to glucagon secretion cause fasting and post-prandial hyperglycemia in patients with diabetes.

Introduction: metformin enhances insulin sensitivity, being used to prevent and treat diabetes, although its mechanism of action remains elusive.

Results: patients with diabetes fail to store glucose as hepatic glycogen via the direct pathway (glycogen synthesis from dietary glucose during the post-prandial period) and via the indirect pathway (glycogen synthesis from "de novo" synthesized glucose) owing to insulin deficiency and glucagon-induced insulin resistance. Read More

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http://dx.doi.org/10.2174/1573399814666181009125348DOI Listing
October 2018
3 Reads

The impact of depressive symptoms on quality of life of patients with type 2 diabetes in Jazan region, KSA.

Curr Diabetes Rev 2018 Oct 1. Epub 2018 Oct 1.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University. Saudi Arabia.

Purpose: The purpose of this study is to determine the impact of depressive symptoms on the quality of life of type 2 diabetes patients (T2DM).

Method: A cross sectional study of 332 T2DM patients aged ≥18 years living in Jazan region of Saudi Arabia. Validated questionnaire was used for demographic and disease characteristics. Read More

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http://dx.doi.org/10.2174/1573399814666181002100223DOI Listing
October 2018
16 Reads

Glycation and HMG-CoA Reductase Inhibitors: Implication in Diabetes and Associated Complications.

Curr Diabetes Rev 2019 ;15(3):213-223

Clinical Biochemistry & Natural Product Research Lab, Department of Biosciences, Integral University, Lucknow, 226026, U.P, India.

Introduction: Diabetes Mellitus (DM) acts as an absolute mediator of cardiovascular risk, prompting the prolonged occurrence, size and intricacy of atherosclerotic plaques via enhanced Advanced Glycation Endproducts (AGEs) formation. Moreover, hyperglycemia is associated with enhanced glyco-oxidized and oxidized Low-Density Lipoprotein (LDL) possessing greater atherogenicity and decreased the ability to regulate HMG-CoA reductase (HMG-R). Although aminoguanidine (AG) prevents the AGE-induced protein cross-linking due to its anti-glycation potential, it exerts several unusual pharmaco-toxicological effects thus restraining its desirable therapeutic effects. Read More

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http://dx.doi.org/10.2174/1573399814666180924113442DOI Listing
January 2019
5 Reads

Association of High Levels of Spot Urine Protein with High Blood Pressure, Mean Arterial Pressure and Pulse Pressure with Development of Diabetic Chronic Kidney Dysfunction or Failure among Diabetic Patients. Statistical Regression Modeling to Predict Diabetic Proteinuria.

Curr Diabetes Rev 2018 Sep 24. Epub 2018 Sep 24.

Aseer Endocrine and Diabetes Center of Aseer Central Hospital, Ministry of Health, Abha. Saudi Arabia.

Introduction: In research elevated blood pressure (BP) has been demonstrated to be a risk for the development of nephropathy and chronic renal disease (CKD) or diabetic kidney disease(DKD) among diabetics. However, no study has find correlation for the spot urine protein (UPr) excretion with elevated BP, pulse pressure (PP) and mean arterial pressure MAP). This technique was invented in the current study. Read More

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http://dx.doi.org/10.2174/1573399814666180924114041DOI Listing
September 2018
2 Reads

Lignans' potential in pre- and post-onset type 2 diabetes management.

Curr Diabetes Rev 2018 Sep 13. Epub 2018 Sep 13.

Department of Health Sciences and Emergency Management, Cape Breton University, Sydney, Nova Scotia. Canada.

Introduction: Type 2 diabetes (T2D) cases continue to rise dramatically despite efforts to get people to exercise and eat with a view to health and combatting the cluster of 7 issues (elevated waist circumference, hyperglycaemia, hypertension, dyslipidemia, pro-thrombotic state, increased oxidation (including low density lipoprotein (LDL)) and the pro-inflammatory state associated with pre- and post-onset T2D.

Background: There are numerous medications available to deal with these seven major issues. However, each medication currently available manages a maximum of two cluster members at a time. Read More

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http://dx.doi.org/10.2174/1573399814666180914094520DOI Listing
September 2018
24 Reads

Association of PPARG gene polymorphisms Pro12Ala with type 2 diabetes mellitus: A meta-analysis.

Curr Diabetes Rev 2018 09 12. Epub 2018 Sep 12.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Background: Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000. Read More

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http://dx.doi.org/10.2174/1573399814666180912130401DOI Listing
September 2018
10 Reads

Is there a role for Sodium orthovanadate in the treatment of diabetes?

Curr Diabetes Rev 2018 Sep 3. Epub 2018 Sep 3.

Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab. India.

Background and Introduction: Diabetes is a metabolic disorder, whose incidences are increasing day by day. Various classes of anti-diabetic drugs are clinically approved by the Food and Drug Administration (FDA) for treatment of diabetes mellitus, but unfortunately, none of them is able to treat this condition. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more safe and effective anti-diabetic agents. Read More

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http://dx.doi.org/10.2174/1573399814666180903162556DOI Listing
September 2018
30 Reads

Concurrent And Longitudinal Association Between Glycemic Control And Self Reported Medication Adherence Among Type 2 Diabetes Patients At A Tertiary Care Hospital In Malaysia.

Curr Diabetes Rev 2018 Aug 28. Epub 2018 Aug 28.

Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300. Malaysia.

Background: This study evaluated the association of self reported adherence with concurrent and subsequent glycemic control amongst type 2 diabetes patients at a tertiary care hospital in Malaysia.

Method: Demographic and clinical variables were assessed at baseline, after three and six months in 73 type 2 diabetes patients. Regression analysis, using SPSS, evaluated the concurrent and longitudinal association of medication adherence and glycemic control. Read More

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http://dx.doi.org/10.2174/1573399814666180828152754DOI Listing
August 2018
3 Reads

Potential Utility of Self-Report Measures of Affect to Optimise Exercise Adherence in People with Type 2 Diabetes.

Curr Diabetes Rev 2018 Aug 16. Epub 2018 Aug 16.

School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia. Australia.

Exercise is essential for managing type 2 diabetes, however approximately only 40% of people with the condition meet guidelines. The aim of this review is to examine the evidence regarding the use self-report measures of affect to understand and predict exercise adherence. Self-reported affect has been successfully used to regulate exercise intensity, monitor training load, prevent injury, and predict future physical activity participation in otherwise healthy and some clinical populations. Read More

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http://dx.doi.org/10.2174/1573399814666180816165351DOI Listing
August 2018
17 Reads

Evaluation of Risk Factors Associated with Diabetic Foot Ulcers in Saudi Arabia.

Curr Diabetes Rev 2019 ;15(3):224-232

Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background And Aims: Considering that diabetic foot ulceration is one of the major health issues globally, we aimed to evaluate the risk factors associated with foot ulcers in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 81 T2DM patients (age range: 40-80 years) registered at the Diabetes Treatment Center, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia between April and September 2015 were included in this cross-sectional study after purposive selection and assigning of patient numbers. The selected participants were interviewed and examined, and their medical records were reviewed for sensory, vibratory, and painful neuropathies; vascular insufficiency; retinopathy; and dermatological variations. Read More

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http://dx.doi.org/10.2174/1573399814666180816165848DOI Listing
January 2019
6 Reads

Hormonal, Metabolic and Hemodynamic Adaptations to Glycosuria in Type 2 Diabetes Patients Treated with Sodium-Glucose Co-Transporter Inhibitors.

Curr Diabetes Rev 2018 Aug 13. Epub 2018 Aug 13.

Department of Medicine, Division of Metabolism, Endocrinology & Genetics University of Kansas Medical Center Kansas City, KS. United States.

Background & Introduction: The advent of the sodium-glucose cotransporter-2 inhibitors [SGLT-2i] provides an additional tool to combat diabetes and complications. The use of SGLT-2i leads to effective and durable glycemic control with important reductions in body weight/fat and blood pressure. These agents may delay beta-cell deterioration and improve tissue insulin sensitivity, which might slow the progression of the disease. Read More

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http://dx.doi.org/10.2174/1573399814666180813124645DOI Listing
August 2018
4 Reads

Impaired Awareness of Hypoglycaemia in Insulin-treated Type 2 Diabetes Mellitus.

Curr Diabetes Rev 2018 Aug 6. Epub 2018 Aug 6.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110. Jordan.

Background: Patients with Type 2 Diabetes Mellitus (T2DM) may develop hypoglycemia as an adverse effect of insulin therapy. Hypoglycemia has dangerous consequences that result from neuroglycopenia and hypersecretion of counter-regulatory hormones. Patients who recognize early symptoms of hypoglycemia can initiate self-treatment and rectify the situation. Read More

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http://dx.doi.org/10.2174/1573399814666180806144937DOI Listing
August 2018
13 Reads

Androgen Therapy in Male Patients Suffering from Type 2 Diabetes: A Review of Benefits and Risks.

Curr Diabetes Rev 2018 Jul 31. Epub 2018 Jul 31.

Alberta Institute of Diabetes and Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton. Canada.

Background: The current estimated numbers of patients with type 2 diabetes (T2D) is believed to be close to 10% of the whole populations of many geographical regions, causing serious concerns over the resulting elevated morbidity and mortality as well as the impact on health care systems around the world. In addition to negatively affecting quality of life, diabetes is associated with cardiovascular and cerebrovascular complications, indicating that appropriate drug therapy should not only deal with metabolic dysfunction, but also protect the vascular system, kidney function and skeletal muscle mass from the effects of the epigenetic changes induced by hyperglycaemia.

Objective: To provide an insight into management of hypogonadism associated with T2D, this review focuses on clinical observations related to androgen therapy in qualified diabetic patients, and discusses the lines of evidence for its benefits and risks. Read More

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http://dx.doi.org/10.2174/1573399814666180731125724DOI Listing
July 2018
16 Reads

Studying the Gut Microbiome of Latin America and Hispanic/Latino populations. Insight into Obesity and Diabetes. Systematic Review.

Curr Diabetes Rev 2018 07 30. Epub 2018 Jul 30.

Harvard Medical School, Boston. United States.

Background People from Latin America (LA) and the Hispanic/Latino community living in the United States (LUS) exhibit a high prevalence of diabetes (DM) and obesity (OB). The gut microbiome (GM) is capable of altering energy regulation and glucose metabolism, but for the expression of these diseases a combination of multiple factors such as ethnicity, genetic and nutritional factors are required. A systematic research was conducted to understand if the prevalence of OB and/or DM has an interaction with the GM in LA and LUS. Read More

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http://eurekaselect.com/164161
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http://dx.doi.org/10.2174/1573399814666180730124817DOI Listing
July 2018
8 Reads

Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes.

Curr Diabetes Rev 2019 ;15(3):199-204

HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Read More

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http://dx.doi.org/10.2174/1573399814666180730105351DOI Listing
January 2019
9 Reads

Genetic Aspects of Latent Autoimmune Diabetes in Adults: A Mini-Review.

Curr Diabetes Rev 2019 ;15(3):194-198

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Diabetes is a multifactorial disease, caused by a complex interplay between environmental and genetic risk factors. Genetic determinants of particularly Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D) have been studied extensively, whereas well-powered studies of Latent Autoimmune Diabetes in Adults (LADA) are lacking. So far available studies support a clear genetic overlap between LADA and T1D, however, with smaller effect sizes of the T1D-risk variants in LADA as compared to T1D. Read More

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http://dx.doi.org/10.2174/1573399814666180730123226DOI Listing
January 2019
9 Reads