449 results match your criteria Current Clinical Pharmacology[Journal]


Impact of ondansetron on withdrawal signs, fentanyl requirement and pain relief in opioid addicted patients under general anesthesia.

Curr Clin Pharmacol 2019 Jan 31. Epub 2019 Jan 31.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman. Iran.

Background: Serotonin 5-HT3 receptor antagonists such as ondansetron have been investigated to attenuate opioid withdrawal signs in studies.

Objective: Therefore, we designed a randomized double-blinded placebo-controlled trial to evaluate this effect in opioid-addicted patients who were admitted to orthopedic department for surgery due to bone fractures.

Method: Male adults who were addicted to opioids, aged 18 to 79 years were enrolled (n=96) and randomized into two oral doses (4 & 8 mg) of ondansetron (n=32) and placebo (n=32). Read More

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http://dx.doi.org/10.2174/1574884714666190131122846DOI Listing
January 2019
1 Read

Drug-Induced Peripheral Neuropathy, a Narrative Review.

Curr Clin Pharmacol 2019 Jan 21. Epub 2019 Jan 21.

Valley Anesthesiology and Pain Consultants, Phoenix, AZ; University of Arizona College of Medicine-Phoenix, Phoenix, AZ; Creighton University School of Medicine, Omaha, NE. United States.

Peripheral neuropathy is a painful condition deriving from many and varied etiologies. Certain medications have been implicated in the iatrogenic development of drug induced peripheral neuropathy (DIPN) and include chemotherapeutic agents, antimicrobials, cardiovascular drugs, psychotropic, anticonvulsants, among others. In many cases, DIPN develops in a dose dependent fashion following continued use of a neurotoxic agent. Read More

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http://dx.doi.org/10.2174/1574884714666190121154813DOI Listing
January 2019

The Effect of methylphenidate on Reed Scaling in Benzodiazepine Poisoning, A Prospective Trial.

Curr Clin Pharmacol 2019 Jan 12. Epub 2019 Jan 12.

Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran. Iran.

Background: Benzodiazepine is one of the most important causes of substance abuse and intoxication throughout the world and Iran.

Objective: The aim of our study was to determine the role of stimulants in reversing CNS level in acute Benzodiazepine poisoning patients who were hospitalized a referral poison center.

Method: This was a randomized double-blind, placebo-controlled trial study on 32 cases with pure acute Benzodiazepine poisoning from March 2016 to February 2017. Read More

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http://dx.doi.org/10.2174/1574884714666190112153157DOI Listing
January 2019
4 Reads

Efficacy and safety of Nilutamide in patients with metastatic prostate cancer who underwent orchiectomy: A systematic review and meta-analysis.

Curr Clin Pharmacol 2019 Jan 12. Epub 2019 Jan 12.

Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab 142001. India.

Background: Prostate cancer is the sixth leading cause of death, among the death caused due to cancer. By 2030, the burden is expected an increase with 1.7 million new cases and 499,000 new deaths. Read More

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http://dx.doi.org/10.2174/1574884714666190112151202DOI Listing
January 2019
1 Read

Metformin And Pregnancy Outcomes: Evidence Gaps And Unanswered Questions.

Curr Clin Pharmacol 2018 Dec 24. Epub 2018 Dec 24.

Universidad de Buenos Aires, Facultad de Medicina, Centro de Vigilancia y Seguridad de Medicamentos,Departamento de Toxicología y Farmacología,Buenos Aires. Argentina.

Background: Metformin is sometimes used as an alternative to insulin in gestational diabetes mellitus (GDM). It is also used to achieve ovulation in polycystic ovary syndrome (PCOS). Pre-natal exposure to metformin results from its continuation after a successful ovulation in women with PCOS, its maintenance in women with pre-gestational diabetes or the installation of metformin in GDM. Read More

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http://dx.doi.org/10.2174/1574884714666181224151116DOI Listing
December 2018
9 Reads

The possibility of therapeutic drug monitoring of the most important interactions in nursing homes.

Curr Clin Pharmacol 2018 Dec 24. Epub 2018 Dec 24.

Department of Clinical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen. Norway.

Background: Therapeutic drug monitoring is a relevant tool in drug treatment of elderly patients.

Objective: The aim of this study was to assess the possibility of therapeutic drug monitoring of the most important potential interactions in nursing homes.

Method: A material of prescribed drugs to 446 patients in three nursing homes in Bergen, Norway from a single day in March 2016 was analysed. Read More

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http://dx.doi.org/10.2174/1574884714666181224144722DOI Listing
December 2018
1 Read

Protective effect of Selenium-L-methionine on radiation-induced acute pneumonitis and lung fibrosis in rat.

Curr Clin Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (International Campus), Tehran. Iran.

Background: In this study, we aimed to detect the changes in the level of interleukin (IL)-4 and IL-13 cytokines and their downstream genes including interleukin-13 receptor subunit alpha-2 (IL13Ra2), interleukin-4 receptor subunit alpha-1 (IL4Ra1), dual oxidase 1 (DUOX1) and dual oxidase 2 (DUOX2). The protective effects of Selenium-L-methionine on radiation-induced histopathological damages and changes in the level of these cytokines and genes were detected.

Methods: Four groups of 20 rats (5 rats in each) namely control; Selenium-L-methionine, radiation; and radiation plus Selenium-L-methionine, were used in this study. Read More

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http://dx.doi.org/10.2174/1574884714666181214101917DOI Listing
December 2018
10 Reads

Role of muscarinic acetylcholine receptors in Breast Cancer. Design of metronomic chemotherapy.

Curr Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET. 2da Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires. Argentina.

Background: Muscarinic acetylcholine receptors (mAChRs) have attracted interest as targets for therapeutic interventions in different illnesses like Alzheimer´s disease, viral infections and different tumors. Regarding the latter, many authors have studied each subtype of mAChRs, which seem to be involved in the progression of distinct types of malignancies.

Methods: We carefully revised research literature focused on mAChRs expression and signaling as well as in their involvement in cancer progression and treatment. Read More

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http://dx.doi.org/10.2174/1574884714666181203095437DOI Listing
December 2018
11 Reads

Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice.

Curr Clin Pharmacol 2018 Nov 21. Epub 2018 Nov 21.

I.T.S College of Pharmacy, Ghaziabad, Uttar Pradesh. India.

Background: Epilepsy is one of the most common and severe brain disorders in the world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability and inhibition. Oxidative stress is a biochemical state in which reactive oxygen species are generated and associated with various diseases including epilepsy. Pycnogenol, a polyphenol obtained from the pine tree and has antioxidant& anti-inflammatory activity. Read More

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http://dx.doi.org/10.2174/1574884714666181122110317DOI Listing
November 2018
10 Reads

Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles.

Curr Clin Pharmacol 2018 Nov 19. Epub 2018 Nov 19.

Universiti Teknologi MARA, Faculty of Pharmacy, Bandar Puncak Alam, 42300 Selangor . Malaysia.

Background: Recombinant human keratinocyte growth factor (rHuKGF) has gained considerable attention by researchers as epithelial cells proliferating agent. Moreover, intravenous truncated rHuKGF (palifermin) has been approved by Food and Drug Administration (FDA) to treat and prevent chemotherapy-induced oral mucositis and small intestine ulceration. The labile structure and short circulation time of rHuKGF in-vivo are the main obstacles that reduce the oral bioactivity and dosage of such proteins at the target site. Read More

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http://dx.doi.org/10.2174/1574884714666181120103907DOI Listing
November 2018
10 Reads

The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy.

Curr Clin Pharmacol 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Pharmacology, SRM MCH &RC, Kattankulathur, Chennai, Tamil Nadu. India.

Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon. Read More

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http://dx.doi.org/10.2174/1574884713666181116100946DOI Listing
November 2018
14 Reads

The cytotoxicity and synergistic potential of aspirin and aspirin analogues towards oesophageal and colorectal cancer.

Curr Clin Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton WV1 1 LY. United Kingdom.

Background: Oesophageal cancer (OC) is a deadly cancer because of its aggressive nature with survival rates that have barely improved in decades. Epidemiologic studies have shown that low-dose daily intake of aspirin can decrease the incidence of OC.

Methods: The toxicity of aspirin and aspirin derivatives to OC and a colorectal cancer (CRC) cell line were investigated in the presence and absence of platins. Read More

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http://dx.doi.org/10.2174/1574884713666181112141151DOI Listing
November 2018
6 Reads

Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity.

Curr Clin Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry. India.

Aim Multiple drug intolerance syndrome (MDIS) is a unique clinical entity distinct from other drug hypersensitivity syndromes. The aim of this review was to critically appraise the various aspects of MDIS. Methods A review was conducted to search for the causes, mechanism, clinical features, and management of MDIS. Read More

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http://dx.doi.org/10.2174/1574884713666181112125714DOI Listing
November 2018
11 Reads

Desensitization Of 5-Ht-1a Somatodentritic Receptors In Tryptophan Treated And Co-Treated Rats Induced By Methylphenidate.

Curr Clin Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Department of Biochemistry, University of Karachi ,Karachi. Pakistan.

Background: Psychostimulants can induce behavioral sensitization by their chronic use. The main target for the action of these drugs is dopamine, nor epinephrine and serotonin transporters. Serotonin is synthesized by the precursor L-tryptophan. Read More

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http://dx.doi.org/10.2174/1574884713666181112123309DOI Listing
November 2018
1 Read

The added value of liquid antipsychotics: the case of quetiapine.

Curr Clin Pharmacol 2018 Nov 2. Epub 2018 Nov 2.

Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki. Greece.

Background: Antipsychotic drugs are the cornerstone of schizophrenia treatment but are also indicated for other psychotic and mood disorders. Different antipsychotic drugs and their formulations are available, though liquid forms have been overlooked.

Methods: Herein the added value of liquid antipsychotics is reviewed, with a focus on the recently introduced liquid quetiapine, a frequently used antipsychotic. Read More

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http://dx.doi.org/10.2174/1574884713666181102145236DOI Listing
November 2018
4 Reads

Efficacy Of Zofenopril Alone Or In Combination With Hydrochlorothiazide In Patients With Kidney Dysfunction.

Curr Clin Pharmacol 2018 Oct 25. Epub 2018 Oct 25.

Unit of Internal Medicine, Policlinico S. Orsola, University of Bologna, Bologna. Italy.

Hypertension and kidney disease often coexist, further increasing the risk of future cardiovascular events. Treatment of hypertensive adults with an angiotensin converting enzyme inhibitor in case of concomitant kidney disease may slow disease progression. The third-generation liphophilic angiotensin converting enzyme inhibitor zofenopril, administered alone or combined with a thiazide diuretic, has proved to be effective in lowering blood pressure in hypertensive patients and to reduce the risk of fatal and non-fatal events in post-acute myocardial infarction and heart failure. Read More

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http://dx.doi.org/10.2174/1574884713666181025145404DOI Listing
October 2018
7 Reads

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization.

Curr Clin Pharmacol 2018 Oct 25. Epub 2018 Oct 25.

Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan. Iran.

Nowadays, ionizing radiation is used for several applications in medicine, industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing radiation, there are some concerns for accidental exposure to radioactive sources. The threat posed by its use in terrorism is of global concern. Read More

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http://dx.doi.org/10.2174/1574884713666181025141559DOI Listing
October 2018
18 Reads

Biosimilars: an approach to current worldwide regulation frameworks.

Curr Clin Pharmacol 2018 Oct 25. Epub 2018 Oct 25.

Riesgo de Fractura S.A. Cayre IPS, Bogotá. Colombia.

Developing new biological medicaments has led to the regulations and norms regarding such drugs, in terms of marketing, prescription, use, interchangeability and switching, have become fundamental aspects guaranteeing their safety, quality and effectiveness. Biologics are of great importance in treating patients suffering rheumatic, autoimmune, inflammatory, neoplastic and other diseases. The expiry/lapse of reference biologics or originators' patents has meant that developing biosimilars needs accompanying legal requirements for their approval in countries worldwide. Read More

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http://dx.doi.org/10.2174/1574884713666181025142928DOI Listing
October 2018
2 Reads

A Critique of Computer Simulation Software's Used in Pharmacokinetics and Pharmacodynamics Analysis.

Curr Clin Pharmacol 2018 ;13(4):216-235

Department of Physiology, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria.

Background: In the pharmaceutical sectors, the computer plays a crucial role as a commander of all the theoretical aspects and provides a workbench to improve the overall quality of pharmaceutical research and development. The aim of this article is to provide a computational approach to the development of numerous technology of computer software in the field of clinical pharmacokinetics. The computational technique practised by clinical pharmacist and scientist with the applied knowledge and skills in dealing with clinical pharmacokinetics problems can be applied in routine clinical practices. Read More

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http://dx.doi.org/10.2174/1574884713666181025144845DOI Listing
January 2018
12 Reads

Anaemogenic, Obesogenic and Thermogenic Potentials of Graded Doses of Monosodium Glutamate Sub-acutely Fed to Experimental Wistar Rats.

Curr Clin Pharmacol 2018 ;13(4):273-278

Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria.

Background: Monosodium Glutamate (MSG) is one of the most commonly used food additives for the enhancement of food taste and flavour. There are several conflicting reports of toxicity or otherwise safety of the compound, which raises a growing concern regarding the safety of monosodium glutamate as a food additive.

Objective: In the present study, we sought to investigate the effect of monosodium glutamate on body weight, feed consumption, body temperature and some haematological parameters. Read More

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http://www.eurekaselect.com/165838/article
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http://dx.doi.org/10.2174/1574884713666181002120657DOI Listing
January 2018
5 Reads

Role of Nrf2/HO-1 and PI3K/AKT Genes In The Hepatoprotective Effect of cilostazol.

Curr Clin Pharmacol 2018 Sep 3. Epub 2018 Sep 3.

Department of Biochemistry, Faculty of Medicine, Minia University, 61511 Minia. Egypt.

Background: Cilostazol, a phosphodiesterase 3 inhibitor (PDE3I), is a platelet aggregation inhibitor and vasodilator that is useful for treating intermittent claudication. Experimental studies have shown that cilostazol has potent anti-inflammatory, anti-oxidant effects effects Objectives: Although the hepatoprotective effect cilostazol has been studied, the molecular mechanisms of such protection, including: the nuclear factor-erythroid 2-related factor 2 (Nrf2) / hemoxygenase (HO-1) and the phosphoinositide 3-kinase (PI3K) /serine/threonine kinase (Akt) pathways are not fully explored, which is the aim of this study.

Method: For that aim, 35 rats were grouped into: control groups, liver injury group (model- non treated: injected with thioactamide (TAA), 150 mg/kg, i. Read More

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http://dx.doi.org/10.2174/1574884713666180903163558DOI Listing
September 2018
12 Reads

Preface: Vitamin D and QT Interval in Epilepsy: More than an Association?

Curr Clin Pharmacol 2018 ;13(1):2-3

Department of Internal Medicine, Polyclinic IRCCS, Ospedale Maggiore, University of Milan, Milan, Italy.

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http://dx.doi.org/10.2174/157488471301180820113149DOI Listing
January 2018
3 Reads

Lipid-based siRNA Nanodelivery Systems: A Learning Process for Improving Transfer from Concepts to Clinical Applications.

Curr Clin Pharmacol 2018 ;13(3):142-163

Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, Junin 956 (C1113AAD) Ciudad Autonoma de Buenos Aires, Argentina.

Background: The molecular mechanism of silencing genes using small interference RNA is as particular and innovative phenomenon as the proposed delivery systems to release them. Recent advances in RNAi have resulted in the development of multiple siRNA candidates that are currently being evaluated in preclinical / clinical instances. SNALP®, Atuplex® and Rondel® technologies stand out; they are mainly based on polymers, cyclodextrins or lipids. Read More

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http://dx.doi.org/10.2174/1574884713666180829143054DOI Listing
January 2018
10 Reads

Interventions for Improving Bone Mineral Density and Reducing Fracture Risk in Osteogenesis Imperfecta: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials.

Curr Clin Pharmacol 2018 ;13(3):190-198

School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.

Background: Osteogenesis imperfecta is a rare metabolic disorder associated with reduced mineralization of bone and corresponds to increased fracture risk. We carried out the present network meta-analysis comparing all the medical interventions for osteogenesis imperfecta.

Method: Electronic databases were searched for randomized controlled clinical trials evaluating the use of drugs in patients with osteogenesis imperfecta. Read More

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http://dx.doi.org/10.2174/1574884713666180829143927DOI Listing
January 2018
22 Reads

Evaluating the Effects of Oral and Topical Simvastatin in the Treatment of Acne Vulgaris: A Double-blind, Randomized, Placebo-controlled Clinical Trial.

Curr Clin Pharmacol 2018 ;13(4):279-283

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Acne vulgaris is a common dermatologic disorder which results in psychological consequences. Inflammatory responses play an important role in the development of inflammatory acne lesions. Recently, many studies have demonstrated anti-inflammatory effects of statins; thus, the aim of this study was to evaluate the efficacy of oral and topical Simvastatin as adjunct therapy in the treatment of acne vulgaris. Read More

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http://dx.doi.org/10.2174/1574884713666180821143545DOI Listing
January 2018
8 Reads

How to Design and Validate A Questionnaire: A Guide.

Curr Clin Pharmacol 2018 ;13(4):210-215

Department of Gynaecology and Obstetrics, AIIMS Jodhpur, Rajasthan, India.

Background: A questionnaire is a commonly used data collection method and is a very crucial part of the research. However, designing a questionnaire can be a daunting task for postgraduate students.

Methods: This manuscript illustrates the various steps required in questionnaire designing and provides an insight into the essentials of questionnaire construction and validation. Read More

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http://www.eurekaselect.com/164433/article
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http://dx.doi.org/10.2174/1574884713666180807151328DOI Listing
January 2018
5 Reads

SGLT-2 Inhibitors in Type 1 Diabetes Mellitus: A Comprehensive Review of the Literature.

Curr Clin Pharmacol 2018 ;13(4):261-272

Second Propedeutic Department of Internal Medicine, Hippokration Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Sodium-Glucose Cotransporter 2 (SGTL-2) inhibitors are a new class of antidiabetics, which have been approved for the treatment of patients with Type 2 Diabetes Mellitus (T2DM). Besides their beneficial metabolic effects, they exert favourable results in cardiovascular events and risk factors along with renoprotection. However, SGLT-2 inhibitors have not been yet approved as an adjunct therapy to insulin in patients with Type 1 Diabetes Mellitus (T1DM). Read More

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http://dx.doi.org/10.2174/1574884713666180807150509DOI Listing
January 2018
18 Reads

A Recent Update on the Effects of Omega-3 Fatty Acids in Alzheimer's Disease.

Curr Clin Pharmacol 2018 ;13(4):252-260

Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur-680 555, Kerala, India.

Dietary long chain polyunsaturated fatty acids belong to omega (ω)-3, -6 or -9 series. Both experimental and clinical studies demonstrated the beneficial effect of ω -3 fatty acids of fish oil, Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) against human ailments including cardiovascular diseases and rheumatoid arthritis. They are metabolized in cyclooxygenase and lipooxygenase pathways and also by cytochrome P450 isozymes. Read More

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http://dx.doi.org/10.2174/1574884713666180807145648DOI Listing
January 2018
2 Reads

Therapeutic Approach for Irritable Bowel Syndrome: Old and New Strategies.

Curr Clin Pharmacol 2018 ;13(3):164-172

Gastroenterology Unit, Brotzu Hospital, Cagliari, Italy.

Background: Irritable bowel syndrome (IBS) is the most frequently diagnosed functional gastrointestinal disorder. It is characterised by abdominal pain, bloating and changes in bowel habits that can have a serious impact on the patient's quality of life. Treatment strategies are based on the nature and severity of the symptoms, the degree of functional impairment of the bowel habits, and the presence of psychosocial disorders. Read More

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http://dx.doi.org/10.2174/1574884713666180807143606DOI Listing
January 2018
7 Reads

Antibody-Drug Conjugates: A Review on the Epitome of Targeted Anti- Cancer Therapy.

Curr Clin Pharmacol 2018 ;13(4):236-251

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

Cancer is one of the deadly diseases which is characterized by unchecked cell division or abnormal cell growth due to the incapability of cell cycle arrest. As the treatment for this is to kill the cancerous cells, the main challenge for scientists is to direct the cell killing to cancerous cells while leaving the normal cells unharmed. Antibody-Drug Conjugates (ADC) are one such targeted anti-cancer therapy. Read More

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http://dx.doi.org/10.2174/1574884712666180802095521DOI Listing
January 2018
21 Reads

Differentially Enhancing Effects of Long-term Treatment with Serrazyme, Boswellia and Pine on Seminal Bacterial Detection in Patients with Chronic Bacterial or Inflammatory Prostatitis, Probably Related to Several Degrees of Bacterial Adherence.

Curr Clin Pharmacol 2018 ;13(3):183-189

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

Background: Prostatitis is a recurrent urinary infection in males and is often difficult to cure. The aim of the study was to examine whether anti-inflammatory effects of enhanced drainage of prostatic secretions, obtained through two months treatment with a proteolytic enzyme mucoactive (PEM) compound (Serrazyme and other constituents), influenced qualitative or quantitative expressions of bacterial growth in seminal cultures.

Method: 450 patients with prostatitis syndromes were randomized either to PEM therapy (intervention group) or to no treatment group. Read More

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http://dx.doi.org/10.2174/1574884713666180803114654DOI Listing
January 2018
7 Reads

Nanovehicle-based Small Interfering RNA (siRNA) Delivery for Therapeutic Purposes: A New Molecular Approach in Pharmacogenomics.

Curr Clin Pharmacol 2018 ;13(3):173-182

Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: RNA interference (RNAi) is a process for regulating the gene expression in which small interfering RNAs (siRNAs) silence target genes. siRNA-based therapy as a new molecular treatment approach, offers therapeutic prospects for many common diseases such as cancer and cardiovascular disorders. Nevertheless, the efficacy of siRNA delivery has, so far, remained a challenging issue. Read More

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http://dx.doi.org/10.2174/1574884713666180709152610DOI Listing
January 2018
1 Read

Second-line Treatment of Advanced Non-small Cell Lung Cancer Non-oncogene Addicted: New Treatment Algorithm in the Era of Novel Immunotherapy.

Curr Clin Pharmacol 2018 ;13(2):76-84

Thoracic Division, Medical Oncology Department, European Institute of Oncology, Milan, Italy.

Background: Most patients with advanced non-small cell lung cancer (NSCLC) have a poor prognosis and receive limited benefit from conventional treatments, especially in later lines of therapy. In recent years, several novel therapies have been approved for second- and third-line treatment of advanced NSCLC beyond old chemotherapy agents (docetaxel and pemetrexed) and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI, erlotinib). In particular, the new antiangiogenetics (nindetanib and ramucirumab) in combination with docetaxel and immunotherapy (nivolumab, pembrolizumab and atezolizumab) have been recently approved and represent new treatment options. Read More

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http://www.eurekaselect.com/163698/article
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http://dx.doi.org/10.2174/1574884713666180711160008DOI Listing
January 2018
22 Reads

Trends of Clinical Trials for Drug Development in Rare Diseases.

Curr Clin Pharmacol 2018 ;13(3):199-208

Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

Background: Drug development for rare diseases is challenging because it is difficult to obtain relevant data from very few patients. It must be informative to grasp current status of clinical trials for drug development in rare diseases.

Objective: Clinical trials in rare diseases are to be outlined and compared among the US, EU and Japan. Read More

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http://dx.doi.org/10.2174/1574884713666180604081349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327118PMC
January 2018
2 Reads

Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients with Non-Hodgkin Lymphoma.

Curr Clin Pharmacol 2018 ;13(1):55-64

Amgen Inc., Thousand Oaks, CA, United States.

Background: Blinatumomab is a bispecific T-cell engager (BiTE®) antibody construct targeting CD3ε on T cells and CD19 on B cells. We describe the relationship between pharmacokinetics (PK) of blinatumomab and pharmacodynamic (PD) changes in peripheral lymphocytes, serum cytokines, and tumor size in patients with non-Hodgkin lymphoma (NHL).

Methods: In a phase 1 study, 76 patients with relapsed/refractory NHL received blinatumomab by continuous intravenous infusion at various doses (0. Read More

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http://www.eurekaselect.com/162274/article
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http://dx.doi.org/10.2174/1574884713666180518102514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327122PMC
January 2018
10 Reads

Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.

Curr Clin Pharmacol 2018 ;13(2):120-127

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes.

Methods: The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation was determined.

Results: Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 µg/ml, after 6 h of incubation. Read More

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http://www.eurekaselect.com/162196/article
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http://dx.doi.org/10.2174/1574884713666180516112920DOI Listing
January 2018
9 Reads

The Effect of Tranexamic Acid on Preventing Post-partum Hemorrhage Due to Uterine Atony: A Triple-blind Randomized Clinical Trial.

Curr Clin Pharmacol 2018 ;13(2):136-139

Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Postpartum haemorrhage (PPH) is an important cause of early maternal death which needs to be controlled.

Objective: This study was designed to compare the effect of intravenous tranexamic acid (TXA) and prostaglandin analogue on reducing PPH resulted from uterine atony in women undergoing C section or vaginal delivery.

Method: A randomized, triple-blind, placebo-controlled study was conducted on 248 pregnant women with PPH due to uterine atony who were randomly assigned into two groups of TXA as the intervention group (n=124) and prostaglandin analogue as the control group (n=124). Read More

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http://www.eurekaselect.com/161845/article
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http://dx.doi.org/10.2174/1574884713666180507101002DOI Listing
January 2018
9 Reads

Phase IV Studies: Some Insights, Clarifications, and Issues.

Curr Clin Pharmacol 2018 ;13(1):14-20

Department of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Faculty of Medicine and Surgery, University of Milano, Milano, Italy.

Background: There is an increasing need to face regulatory aspects as well as ethics and scientific ones in the pharmaceutical research phase after the authorization of a drug. Traditionally, Phase IV studies, after the authorization of a drug to be marketed by the Competent Authority like the Food and Drug Administration (FDA) (in Europe, European Medicine Agency - EMA- through National Procedures or Community Procedures) have been considered mainly aimed to the assessment of the new drug safety profile. However, the sample size calculation for such aim is still an open issue. Read More

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http://dx.doi.org/10.2174/1574884713666180412152949DOI Listing
January 2018
18 Reads

The Benefit of Prescribing Vitamin D as Add on Therapy on the Electrocardiographic Changes in Epileptic Patients.

Curr Clin Pharmacol 2018 ;13(1):40-44

Department of Pharmacology and Therapeutics, Visitor Professor of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq.

Background: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events.

Objective: This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs. Read More

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http://dx.doi.org/10.2174/1574884713666180412151139DOI Listing
January 2018
7 Reads

Targeting Brain Tumors with Nanomedicines: Overcoming Blood Brain Barrier Challenges.

Curr Clin Pharmacol 2018 ;13(2):110-119

Department of Molecular Oncology, Scintilla Academy for Applied Sciences' Education & Research (www.scintillaacademy.com), India.

Background: This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the BBB/ BTB to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that has an impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment. Read More

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http://www.eurekaselect.com/161227/article
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http://dx.doi.org/10.2174/1574884713666180412150153DOI Listing
January 2018
6 Reads

Lupus Nephritis: A Treatment Update.

Curr Clin Pharmacol 2018 ;13(1):4-13

Division of Nephrology, University of Missouri Health Science Center, Columbia, MO 65212, United States.

Background: Lupus nephritis (LN) is a common complication in many patients with systemic lupus erythematosus, although renal-limited lupus nephritis has been reported as well. Early diagnosis of lupus nephritis is critical as early detection and effective treatment can improve renal outcomes in such patients.

Objective: The treatment of lupus nephritis is largely determined based on the histological class present on the renal biopsy specimen. Read More

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http://www.eurekaselect.com/160960/article
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http://dx.doi.org/10.2174/1574884713666180403150359DOI Listing
January 2018
96 Reads

Hepatic Elimination of Drugs in Gestational Diabetes.

Curr Clin Pharmacol 2018 ;13(1):21-27

Universidad de Buenos Aires, Facultad de Medicina, Departamento de Farmacología y Toxicología, Centro de Vigilancia y Seguridad de Medicamentos, 1053 Buenos Aires, Argentina.

Background: The liver is the major metabolic clearance organ for chemical agents from the human body. Pregnancy is associated with several physiological changes that may affect one or more of these factors, and also induces changes in the hepatic clearance of certain drugs. The aim of this paper was to review some of the currently available information in the field to provide some insights about the relevance of these changes on the clearance of some drugs. Read More

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http://dx.doi.org/10.2174/1574884713666180326104613DOI Listing
January 2018
9 Reads

Knowledge, Attitudes, and Practices of Pharmacovigilance and ADRs Spontaneous Reporting Among Pediatricians and Pediatric Residents in Jordan.

Curr Clin Pharmacol 2018 ;13(1):45-54

Department of Family Medicine, Ministry of Health, Jordan.

Introduction: Pharmacovigilance (PV) is the science responsible for ADRs reporting and accordingly medication safety. Pediatrics age group is a special concern as they have a higher risk of developing ADRs; this put more burden on pediatricians for early detection and reporting of ADRs. The present study aims to explore pediatricians' knowledge, attitude, and practices of pharmacovigilance. Read More

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http://dx.doi.org/10.2174/1574884713666180308151805DOI Listing
January 2018
6 Reads

Formulation of Herbal Fast Disintegrating Tablets and its ex-vivo Study for Anti-histaminic Activity in Guinea Pig Ileum.

Curr Clin Pharmacol 2018 ;13(2):128-135

I.T.S College of Pharmacy, Murad Nagar, Ghaziabad (U.P.), India.

Objective: The aim of present research work was to develop a herbal fast disintegrating tablet containing Fagonia schweinfurthii Hadidi dried extract and determining its antihistaminic activity using guinea pig ileum.

Method: The tablets were formulated by wet granulation technique using three different superdisintegrants (croscarmillose, crospovidone and sodium starch glycolate) at three different levels. The tablets were evaluated for various physical properties like hardness, friability weight variation etc. Read More

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http://www.eurekaselect.com/160369/article
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http://dx.doi.org/10.2174/1574884713666180309153942DOI Listing
January 2018
18 Reads

Determination of Parameters of Oxidative Stress in vitro Models of Neurodegenerative Diseases-A Review.

Curr Clin Pharmacol 2018 ;13(2):100-109

Department of Biotechnology, Sant Gadge Baba Amravati University Amravati- 444 602, Maharashtra, India.

Oxidative stress is a major mechanism underlying the development of various neurodegenerative diseases (Alzheimer, Parkinson, Huntington and amyotrophic lateral sclerosis). Excessive formation of reactive oxygen species (ROS) and nitrogen (RNSs) can overburden the ability of the enzymatic antioxidant defense mechanisms (superoxide dismutase, catalase and glutathione reductase) and non-enzymatic (uric acid, ascorbic acid, α-tocopherol and reduced glutathione), causing the development of oxidative stress, and consequently, impairing the neuronal system cells by means of oxidative damage to a variety of important biological molecules such as lipids, DNA and proteins. Considering the importance of oxidative stress in neurodegenerative diseases, the present review aims to address the main parameters evaluated in in vitro studies on oxidative stress in different models of neurodegenerative diseases. Read More

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http://dx.doi.org/10.2174/1574884713666180301091612DOI Listing
January 2018
5 Reads

Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats.

Curr Clin Pharmacol 2018 ;13(1):65-72

Department of Pharmacology, Seth GS Medical College & KEM Hospital, Maharashtra 400012, Mumbai, India.

Introduction: Anxiety and negative sensations due to alcohol withdrawal are factors leading to alcohol relapse and addiction. Minocycline, an antibiotic, can decrease alcohol consumption in rats, however, its effects on alcohol withdrawal anxiety and relapse have not been studied.

Material And Methods: Part 1: Forced alcohol drinking in gradually increasing concentration was administered till day 22 in rats. Read More

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http://dx.doi.org/10.2174/1574884713666180228110310DOI Listing
January 2018
5 Reads

More Evidence for the Therapeutic Role of Pramipexole in Upper Limb Restlessness Due to Cervical Disc Pathology?

Curr Clin Pharmacol 2018 ;13(1):73-74

Istanbul-Medipol University, Department of Neurology, Istanbul, Turkey.

Background: The causal link between upper limb restlessness and cervical disc prolapsus is still unclear, and the exact role of the spinal cord in the origination of limb restlessness is not yet completely understood.

Methods: Here we have evaluated the therapeutic effect of pramipexole (0.5 mg/kg) in a 47-year old male with cervical disc prolapsus who described restlessness in his upper limb and neck. Read More

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http://dx.doi.org/10.2174/1574884713666180227165917DOI Listing
January 2018
9 Reads

Pharmacogenetics of Glucagon-like Peptide-1 Agonists for the Treatment of Type 2 Diabetes Mellitus.

Curr Clin Pharmacol 2017 ;12(4):202-209

Division of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.

Background: Pharmacogenetics is a promising area of medical research, providing methods to identify the appropriate pharmaceutical agent and dosing for each unique patient. Glucagon- like peptide-1 (GLP-1) agonists are a novel therapeutic choice used in the treatment of type 2 diabetes mellitus (T2DM), demonstrating efficacy regarding glycemic control and weight loss. Therapeutic response to GLP-1 agonist treatment is a complex biophenomenon, dependent on a plethora of modifiable (diet, exercise, adherence) and non-modifiable (genetic individual variants, ethnic characteristics) parameters. Read More

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http://www.eurekaselect.com/159993/article
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http://dx.doi.org/10.2174/1574884713666180221121512DOI Listing
January 2017
39 Reads

Drug-induced QT Interval Prolongation in the Intensive Care Unit.

Curr Clin Pharmacol 2017 ;12(4):210-222

University of Buenos Aires, Faculty of Medicine, Drug Safety and Surveillance Center, Laboratory of Cardiovascular Safety of Drugs, Buenos Aires, Argentina.

Background: The most common acquired cause of Long QT syndrome (LQTS) is drug induced QT interval prolongation. It is an electrophysiological entity, which is characterized by an extended duration of the ventricular repolarization. Reflected as a prolonged QT interval in a surface ECG, this syndrome increases the risk for polymorphic ventricular tachycardia (Torsade de Pointes) and sudden death. Read More

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http://dx.doi.org/10.2174/1574884713666180223123947DOI Listing
January 2017
5 Reads

An Evidence-Based Review of Off-Label Uses of Polidocanol.

Curr Clin Pharmacol 2017 ;12(4):223-230

Drug Applied Research Center, Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51656-65811, Iran.

Background: Polidocanol is approved for its competence in the treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated.

Objective: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis and hemorrhoids. Read More

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http://dx.doi.org/10.2174/1574884713666180223121828DOI Listing
January 2017
8 Reads