1,124,772 results match your criteria Current Clinical Pharmacology[Journal]


[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018
1 Read

Xenotransplantation: Progress Along Paths Uncertain from Models to Application.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Translational Medicine and The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful application of allotransplantation, that is, transplantation of human tissue and organs, as a treatment for a variety of diseases, especially organ failure because scarcity of human tissues limited allotransplantation to a fraction of those who could benefit. In principle, use of animals such as pigs as a source of transplants would allow transplantation to exert a vastly greater impact than allotransplantation on medicine and public health. Read More

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December 2018
2 Reads

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines.

Am J Clin Nutr 2018 Dec;108(6):1357-1368

School of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, Canada.

The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consuming FA-containing supplements. Read More

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December 2018

Immune system stimulation increases dietary threonine requirements for protein deposition in growing pigs.

J Anim Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Animal and Food Sciences, Texas Tech University, Lubbock, Texas.

Previous studies have reported an increase in the utilization of threonine (Thr) during immune system stimulation (ISS). However, increased utilization of an amino acid (AA) during ISS may not reflect an increased dietary requirement, as endogenous sources may supply AA to meet the need for enhanced utilization. The current study evaluated the impact of ISS on components of dietary Thr requirements, i. Read More

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December 2018

DNA damage and repair in the female germline: contributions to ART.

Hum Reprod Update 2018 Dec 12. Epub 2018 Dec 12.

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW, Australia.

Background: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. Read More

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December 2018

Log file based Monte Carlo calculations for proton pencil beam scanning therapy.

Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.

Center for Proton Therapy, Paul Scherrer Institute, WMSA/C12, Villigen - PSI, 5232, SWITZERLAND.

Patient specific quality assurance is crucial to guarantee safety in proton pencil beam scanning. In current clinical practice, this requires extensive, time consuming measurements. Additionally, these measurements do not consider the influence of density heterogeneities in the patient and are insensitive to delivery errors. Read More

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December 2018
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Electrical transport and gas sensing characteristics of dielectrophoretically aligned MBE grown catalyst free InAs nanowires.

Nanotechnology 2018 Dec 12. Epub 2018 Dec 12.

DRDO Solid State Physics Laboratory, Lucknow Road, Timarpur, Delhi, Delhi, 110054, INDIA.

In this report, the precise alignment of catalyst free InAs nanowires (NWs) on pre-patterned Au microelectrodes by dielectrophoresis (DEP) technique for gas sensing applications is presented. The catalyst free InAs NWs have been grown on Si (111) substrate by molecular beam epitaxy (MBE) technique. The effect of dispersing solvents, electrode geometries and gaps, magnitude, frequency and duration of applied voltage etc. Read More

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December 2018

A comparison of microbial fuel cell and microbial electrolysis cell biosensors for real-time environmental monitoring.

Bioelectrochemistry 2018 Dec 1;126:105-112. Epub 2018 Dec 1.

McGill University, Bioresource Engineering Department, 21111 Lakeshore Rd., Ste-Anne-de-Bellevue, QC H9X 3V9, Canada; National Research Council of Canada, 6100 Royalmount Ave, Montreal, QC H4P 2R2, Canada. Electronic address:

This study compares the biosensing performance of a microbial fuel cell (MFC) and a microbial electrolysis cell (MEC). Initial tests provided a qualitative comparison of MFC and MEC currents after the anode compartment liquid (anolyte) was spiked with acetate, or sulphates of NH, Na, Mg, Fe, or a fertilizer solution. Current measurements showed that the MFC sensor had a faster response time, higher sensitivity, and faster recovery time after the spike. Read More

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December 2018

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

J Crit Care 2018 Dec 5;50:138-143. Epub 2018 Dec 5.

Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. Read More

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December 2018

Surgical outcomes of renal transplant recipients after abdominal surgery not connected with transplantation A retrospective case-control study.

Int J Surg 2018 Dec 9. Epub 2018 Dec 9.

Department for General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Background: Due to the increasing number of patients after kidney transplantation, elective and emergency surgery of transplanted patients is becoming a relevant challenge in clinical routine. The current data on complication rate of patients after kidney transplantation, which must undergo another elective or emergency abdominal surgery, is inhomogeneous. Therefore, the aim of our study was to evaluate the outcome of renal transplant patients undergoing abdominal and abdominal wall surgery. Read More

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December 2018

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors.

Stem Cell Reports 2018 Dec;11(6):1551-1564

Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada; Departments of Surgery and Cellular and Physiological Sciences, University of British Columbia, 950 28(th) Avenue West, Vancouver, BC V5Z4H4, Canada. Electronic address:

Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing β cells for diabetes treatment. A greater understanding of how β cells form during embryonic development will improve current hESC differentiation protocols. All pancreatic endocrine cells, including β cells, are derived from Neurog3-expressing endocrine progenitors. Read More

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December 2018

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis.

Cell Rep 2018 Dec;25(11):3021-3035.e5

Department of Hematology, Cancer Center Amsterdam (CCA), Amsterdam UMC, VU Medical Center, Amsterdam, the Netherlands. Electronic address:

Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic stem cells (HSCs), we performed gene expression profiling of LSCs, HSCs, and leukemic progenitors all residing within the same AML bone marrow and identified insulin-like growth factor-binding protein 7 (IGFBP7) as differentially expressed. Low IGFBP7 is a feature of LSCs and is associated with reduced chemotherapy sensitivity. Read More

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December 2018
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[High hyperdiploid acute lymphoblastic leukemia is a highly curable subtype of childhood leukemia].

Magy Onkol 2018 Dec 30;62(4):214-221. Epub 2018 Oct 30.

Patológiai Intézet, PTE Klinikai Központ, Pécs, Hungary.

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. In Hungary 60-70 new cases are diagnosed annually. The survival rate is 85-90% in developed countries with current treatment protocols. Read More

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December 2018

Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial.

PLoS One 2018 12;13(12):e0209236. Epub 2018 Dec 12.

Solvet Animal Health, Calgary, Alberta, Canada.

Parturition is a painful event experienced by cows at the onset of lactation. This pain could lead to a reduced feed intake, altered metabolic and immunological status, and a host of other diseases that could seriously limit her productive herd lifespan. The objective of the current study was to assess the effect of administration of a single dose of oral meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on the production and health status of cows during their lactation. Read More

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December 2018

Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D.

PLoS One 2018 12;13(12):e0208806. Epub 2018 Dec 12.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG. Read More

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December 2018

Communicating information on nature-related topics: Preferred information channels and trust in sources.

PLoS One 2018 12;13(12):e0209013. Epub 2018 Dec 12.

Fort Collins Science Center, U.S. Geological Survey, Fort Collins, Colorado, United States of America.

How information is communicated influences the public's environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. Read More

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December 2018

Corticosteroid use and increased CXCR2 levels on leukocytes are associated with lumacaftor/ivacaftor discontinuation in cystic fibrosis patients homozygous for the F508del CFTR mutation.

PLoS One 2018 12;13(12):e0209026. Epub 2018 Dec 12.

Department of Pediatrics, National Jewish Health, Denver, CO, United States of America.

Cystic fibrosis (CF) is the most common life-shortening genetic disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Several current therapies aim at improving availability and/or function of the mutant CFTR proteins. The combination therapeutic lumacaftor/ivacaftor (Orkambi, luma/iva) partially corrects folding and potentiates CFTR function impaired by the F508del mutation. Read More

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December 2018

Comparison of ground reaction force measurements in a population of Domestic Shorthair and Maine Coon cats.

PLoS One 2018 12;13(12):e0208085. Epub 2018 Dec 12.

Department for Companion Animals and Horses, University Clinic for Small Animals, Small Animal Surgery, Section for Physical Therapy, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria.

Current research on gait analysis mostly involves horses and dogs. Feline kinetics and kinematics are being investigated and receiving more clinical interest at present. Ground reaction forces measured on pressure-sensitive mattresses have been established in healthy Domestic Shorthair cats (DSH). Read More

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December 2018

Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function.

PLoS One 2018 12;13(12):e0208231. Epub 2018 Dec 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.

The metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease associated with reduced physical fitness, higher disease burden, and impaired cognitive functions. Little is known about the operation of these risk factors in older adults when considered comprehensively without relying on the cut-off values of the single MetS components. The three main aims of the current study were to: (i) establish a latent metabolic load factor (MetL), using confirmatory factor analysis (CFA), and representing a continuous measure of MetL, defined by indicators that are commonly used to separate MetS groups from healthy individuals; (ii) examine the associations of this MetL factor with objective health, and cognitive function in men and women; (iii) compare the magnitude of these associations to those observed for the individual indicators used to define the MetL factor as well to the classical categorized MetS vs. Read More

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December 2018

Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples.

PLoS One 2018 12;13(12):e0207871. Epub 2018 Dec 12.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.

Background: Exposure to horses can cause severe allergic reactions in sensitized individuals. The breed, American Bashkir Curly Horse is categorized as hypoallergenic, primarily due to reports of allergic patients experiencing fewer symptoms while handling this special breed. The possible reasons for this phenomenon could be lower allergen production and/or reduced allergen release into the air because of increased sebum content in their skin and hair compared to other breeds. Read More

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December 2018
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A new development of non-local image denoising using fixed-point iteration for non-convex ℓp sparse optimization.

PLoS One 2018 12;13(12):e0208503. Epub 2018 Dec 12.

Department of Mathematics, Southern Illinois University-Carbondale, Carbondale, IL, United States of America.

We proposed a new efficient image denoising scheme, which mainly leads to four important contributions whose approaches are different from existing ones. The first is to show the equivalence between the group-based sparse representation and the Schatten-p norm minimization problem, so that the sparsity of the coefficients for each group can be measured by estimating the underlying singular values. The second is that we construct the proximal operator for sparse optimization in ℓp space with p ∈ (0, 1] by using fixed-point iteration and obtained a new solution of Schatten-p norm minimization problem, which is more rigorous and accurate than current available results. Read More

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December 2018

Risk factors for ectopic pregnancy in a population of Cameroonian women: A case-control study.

PLoS One 2018 12;13(12):e0207699. Epub 2018 Dec 12.

Department of Obstetrics and Gynaecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Objective: To identify the risk factors for ectopic pregnancy (EP) in a population of Cameroonian women.

Sample And Methods: We performed a matched case-control study; 88 women with diagnosed EP (cases), and 176 women with first trimester intrauterine pregnancy (IUP) (controls), who underwent questionnaires. Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated and adjusted for potential confounding factors via multivariate logistic regression analysis. Read More

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December 2018

[Lynch syndrome: genetic, clinical and diagnostic aspects].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):265-279

Laboratorio de Genética Humana, Universidad Nacional Mayor de San Marcos. Lima, Perú; Laboratorio de Biología Molecular, Laboratorio Clínico Roe. Lima, Perú.

This review aims to present the genetic, clinical and diagnostic aspects of Lynch syndrome, as well as providing the most relevant information about genetic counseling in these patients and the current recommendations for their surveillance. Read More

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December 2018

Pre-operative Assessment of Bone Quality in Spine Deformity Surgery: Correlation with Clinical Practice and Published Recommendations.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, NYU Langone Health, New York, NY.

Study Design: Retrospective cohort study.

Objective: The goals of this study were to (1) evaluate pre-operative bone quality assessment and intervention practice over time and (2) review the current evidence for bone evaluation in spine fusion surgery.

Summary Of Background Data: Deformity spine surgery has demonstrated improved quality of life in patients however its cost has made it controversial. Read More

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December 2018

Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Monash Medical Centre, Clayton, Victoria, Australia.

Study Design: Reliability Study.

Objective: To evaluate the applicability and reliability of 9.4T MRI in the assessment of degenerative disc disease compared to 3T MRI. Read More

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December 2018

Clinical Management of Pediatric Achalasia: A Survey of Current Practice.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology.

Objectives: Pediatric achalasia is a rare neurodegenerative disorder of the esophagus that requires treatment. Different diagnostic and treatment modalities are available, but there are no data that show how children can best be diagnosed and treated. We aimed to identify current practices regarding the diagnostic and therapeutic approach toward children with achalasia. Read More

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December 2018

Multicenter Validation of the Emotional State Instrument for Dialysis Patients.

Nurs Res 2019 Jan/Feb;68(1):39-47

Rocío Rodríguez-Rey, PhD, is Associate Professor, Department of Psychology, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Spain. Helena García-Llana, PhD, is Psychology Associate Researcher, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. María Paz Ruiz-Álvarez, MP, is Registered Nurse, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain. Alicia Gómez-Gómez, MP, is Registered Nurse, Department of Nephrology, Henares Hospital, Madrid, Spain. Gloria del Peso, PhD, is Nephrology Consultant, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid Spain. Rafael Selgas, PhD, is Department Head, Department of Nephrology, La Paz University Hospital-IdiPAZ, Madrid, Spain.

Background: The Emotional State Instrument for Dialysis Patients (ES-D) is a brief semistructured questionnaire to assess emotional distress in patients undergoing dialysis. It was designed to be administered by a healthcare provider. A previous study showed preliminary indicators of its content and face validity. Read More

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December 2018

ACSM PRE-PARTICIPATION HEALTH SCREENING GUIDELINES: A UK UNIVERSITY COHORT PERSPECTIVE.

Med Sci Sports Exerc 2018 Dec 11. Epub 2018 Dec 11.

Carnegie School of Sport, Leeds Beckett University, Leeds, United Kingdom.

Purpose: Pre-participation health screening is recommended to detect individuals susceptible to serious adverse cardiovascular complications during exercise. Although expert opinion and best available scientific evidence have informed recent modifications, there remains limited experimental data to support or refute current practice. We therefore aimed to quantify the impact of change to the ACSM pre-participation health screening guidelines on risk classification and referral for medical clearance in a large cohort of undergraduate university students. Read More

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December 2018

Patient Reported Outcomes, Functional Assessment and Utility Values in Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Johns Hopkins Wilmer Eye Institute, Maryland USA.

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More

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December 2018

Femoral Neck Fractures in Young Patients: State of the Art.

Authors:
Daniel S Chan

J Orthop Trauma 2019 Jan;33 Suppl 1:S7-S11

Orthopaedic Trauma Institute, NavicentHealth, Macon, GA.

Femoral neck fractures in young patients are uncommon but are often associated with surgical challenges and complications. The quality of reduction, more than time to surgery, has the most impact on optimizing outcomes and function. There is no consensus in the best fixation construct for these fractures. Read More

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January 2019

Treatment of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S1-S6

Department Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Femoral neck fractures in the physiologically young patient are challenging injuries to manage. A tenuous blood supply and the intrasynovial nature of the fracture create a challenging biological environment. To make matters worse, the biomechanics are equally problematic. Read More

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January 2019

Higher in-hospital mortality during weekend admission for acute coronary syndrome: a large-scale cross-sectional Italian study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Cardiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan.

Aims: An increased mortality risk during weekend hospital admission has been consistently observed. In the present study, we evaluated whether the current improvement in management of acute coronary syndromes (ACS) has reduced this phenomenon.

Methods And Results: We extracted data from the Italian National Healthcare System Databank of 80 391 ACS admissions in the region of Lombardia between 2010 and 2014. Read More

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December 2018

En-Bloc Excision of the High-ligated Inferior Mesenteric Vein Pedicle With the Specimen in Patients Undergoing Minimally Invasive and Open Sphincter Saving Rectal Resections for Cancer.

Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Departments of General Surgery.

Although high-ligated pedicle of the inferior mesenteric artery is usually kept in the resected specimens, the value of preserving high-ligated pedicle of the inferior mesenteric vein within the resected specimens of the sphincter saving rectal resections for cancer is not well defined. In the current study, patients undergoing open, laparoscopic, and robotic sphincter saving rectal resection for cancer were prospectively included. Lymph node invasion and presence of lymph nodes along the IMV pedicles were analyzed. Read More

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December 2018
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An integrative review of nurse practitioner education models: Part three of a four-part series on critical topics identified by the 2015 Nurse Practitioner Research Agenda.

J Am Assoc Nurse Pract 2018 Dec;30(12):696-709

Rush University College of Nursing, Chicago, Illinois.

Background And Purpose: Critical research topics were identified after nurse practitioner (NP) organization stakeholders participated in the Fellows of the American Association of Nurse Practitioner, 2015 Nurse Practitioner Research Agenda Roundtable. Strategies and recommendations were identified to support further work examining NP outcomes-based research priorities in four areas: 1) policy and regulation; 2) workforce; 3) education; and 4) practice. For the purpose of this article, we focus on NP education. Read More

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December 2018

Design and Evaluation of a Wireless Electrocardiogram Monitor in an Operating Room: A Pilot Study.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anesthesia and Intensive Care, Military Teaching Hospital "Clermont Tonnerre", Brest, French.

Background: Wired electrocardiogram monitors are an important component of current perioperative monitoring. Wireless monitoring units could help reduce the number of cables attached to patients and thus improve anesthesia ergonomics and patient management. However, there is concern that electromagnetic interference generated by electrosurgical units may prevent effective wireless signals in the operating room. Read More

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December 2018

Artemisinin and its derivatives: a potential treatment for leukemia.

Anticancer Drugs 2019 Jan;30(1):1-18

Department of Pathology.

Artemisinin (ART) and its derivatives are one of the most important classes of antimalarial agents, originally derived from a Chinese medicinal plant called Artemisia annua L. Beyond their outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess both in-vitro and in-vivo activities against various types of cancer. Their anticancer effects range from initiation of apoptotic cell death to inhibition of cancer proliferation, metastasis and angiogenesis, and even modulation of the cell signal transduction pathway. Read More

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January 2019

Exploring the Role of Regional Anesthesia in the Treatment of the Burn Injured Patient: A Narrative Review of Current Literature.

Clin J Pain 2018 Dec 11. Epub 2018 Dec 11.

The University of Queensland, School of Nursing, Midwifery and Social Work, St Lucia, QLD, Australia, 4072.

Objectives: The review article was designed to assess the effectiveness of regional anesthesia, specifically peripheral nerve blocks, in the treatment of burn pain; with noting of clinical indications and contraindications for peripheral nerve block application, along with discussion of evidence-based analgesic strategies for providing improved, comprehensive burn pain management.

Methods: A search of relevant literature was performed using CINAHL, PubMed, EMBASE, Web of Science and SCOPUS with a publication date between January 2005 and December 2017.

Results: The search yielded ten results that met criteria. Read More

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December 2018

Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine/Rheumatology and Clinical Immunology.

Purpose Of Review: This review summarizes recent insights and current understanding of the role of postactivated B cells in SLE and related pathogenic and potential therapeutic implications.

Recent Finding: B cells are considered key players in SLE and experience from various B-cell-targeted therapies underlines their clinical relevance. In the last years, new insights have been obtained on B-cell abnormality within the complex pathophysiology of SLE. Read More

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December 2018

Precise anesthesia in thoracoscopic operations.

Curr Opin Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology.

Purpose Of Review: The current review focuses on precise anesthesia for video-assisted thoracoscopic surgery (VATS) with the goal of enhanced recovery.

Recent Findings: VATS has become an established and widely used minimally invasive approach with broad implementation on a variety of thoracic operations. In the current environment of enhanced recovery protocols and cost containment, minimally invasive VATS operations suggest adoption of individualized tailored, precise anesthesia. Read More

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December 2018

G-protein-coupled formyl peptide receptors play a dual role in neutrophil chemotaxis and bacterial phagocytosis.

Mol Biol Cell 2018 Dec 12:mbcE18060358. Epub 2018 Dec 12.

Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD.

A dogma of innate immunity is that neutrophils use G-Protein-coupled receptors (GPCRs) for chemoattractant to chase bacteria through chemotaxis and then use phagocytic receptors coupled with tyrosine kinases to destroy opsonized bacteria via phagocytosis. Our current work showed that G-protein-coupled formyl peptide receptors (FPRs) directly mediate neutrophil phagocytosis. Mouse neutrophils lacking formyl peptide receptors (Fpr1/2) are defective in the phagocytosis of E. Read More

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December 2018

Exploring natural variation for rice sheath blight resistance in Brachypodium distachyon.

Plant Signal Behav 2018 Dec 12:1-6. Epub 2018 Dec 12.

a Noble Research Institute, LLC ., Ardmore , OK , USA.

Sheath blight caused by the soil borne fungus Rhizoctonia solani AG1-IA is one of the major diseases of rice in the world. Genetic resistance in rice against this disease has not been very successful. Brachypodium distachyon is considered as a model species for several cereal crops and it has been studied in the past to identify novel sources of disease resistance against cereal crop diseases. Read More

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December 2018

Advancements in Life Cycle Human Exposure and Toxicity Characterization.

Environ Health Perspect 2018 Dec;126(12):125001

16 School of Public Health, University of California , Berkeley, California, USA.

Background: The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance to overcome current assessment challenges. The initiative leadership established the Human Toxicity Task Force to develop guidance on assessing human exposure and toxicity impacts. Based on input gathered at three workshops addressing the main current scientific challenges and questions, the task force built a roadmap for advancing human toxicity characterization, primarily for use in life cycle impact assessment (LCIA). Read More

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December 2018

All-Silicon Topological Semimetals with Closed Nodal Line.

J Phys Chem Lett 2018 Dec 12. Epub 2018 Dec 12.

Owing to the natural compatibility with current semiconductor industry, silicon allotropes with diverse structural and electronic properties provide promising platforms for the next-generation Si-based devices. After screening 230 all-silicon crystals in the zeolite frameworks by first-principles calculations, we disclose two structurally stable Si allotropes (AHT-Si and VFI-Si) containing open channels as topological node-line semimetals with Dirac nodal points forming a nodal loop in the k=0 plane of Brillouin zone. Interestingly, their nodal loops protected by inversion and time-reversal symmetries are robust against SU(2) symmetry breaking due to very weak spin-orbit coupling of Si. Read More

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December 2018

LigandScout Remote: A new User-Friendly Interface for HPC and Cloud Resources.

J Chem Inf Model 2018 Dec 12. Epub 2018 Dec 12.

High Performance Computing (HPC) clusters play a major role in scientific research. However, working with these clusters is often cumbersome, especially for researches without formal background in computer science. It requires preparation and transfer of the input data, manual gathering of results, and command-line expertise. Read More

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December 2018

Antibacterial TiCu/ TiCuN multilayer films with good corrosion resistance deposited by axial magnetic field-enhanced arc ion plating.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

In order to develop a novel kind of antibacterial Cu-containing TiN film with good corrosion resistance, impressive mechanical properties and low cytotoxicity, three differently designed multilayer films of TiCu/TiCuN multilayer (M1, M2, M3) were deposited on the surface of 316L stainless steel surface using the axial magnetic field-enhanced arc ion plating (AMFE-ARP) method, in which the interlayer of TiCu was firstly introduced for Cu-containing TiN film in order to improve comprehensive properties especially corrosion resistance of film. The performance of the TiCu/TiCuN multilayer films were compared with that of the two single layers, TiN and TiCuN, which were deposited by the same method and the same total deposition time. The results indicated that the TiCu/TiCuN multilayer film of M2 revealed the best comprehensive corrosion resistance with low electric current values, high pitting potential and high polarization resistance due to the proper thickness of TiCu interlayers and more number of TiCu/TiCuN bilayers. Read More

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December 2018

Tomographic and Biomechanical Scheimpflug Imaging for Keratoconus Characterization: A Validation of Current Indices.

J Refract Surg 2018 Dec;34(12):840-847

Purpose: To analyze the potential benefit of the newly developed Tomography and Biomechanical Index (TBI) for early keratoconus screening.

Methods: In this retrospective study, the discriminatory power of the corneal tomography Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index and the newly developed Corvis Biomechanical Index (CBI) and TBI to differentiate between normal eyes, manifest keratoconus eyes (KCE), very asymmetric keratoconus eyes with ectasia (VAE-E), and their fellow eyes with either regular topography (VAE-NT) or regular topography and tomography (VAE-NTT) were analyzed by applying the t test (for normal distribution), Wilcoxon matched-pairs test (if not normally distributed), and receiver operating characteristic curve (ROC). The DeLong test was used to compare the area under the ROC (AUROC). Read More

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December 2018

Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder.

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Biologic systems involved in the regulation of motor activity are intricately linked with other homeostatic systems such as sleep, feeding behavior, energy, and mood. Mobile monitoring technology (eg, actigraphy and ecological momentary assessment devices) allows the assessment of these multiple systems in real time. However, most clinical studies of mental disorders that use mobile devices have not focused on the dynamic associations between these systems. Read More

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December 2018

Association of Antipsychotic Treatment With Risk of Unexpected Death Among Children and Youths.

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown.

Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications.

Design, Setting, And Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder. Read More

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December 2018
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