1,803 results match your criteria Current Cardiology Reports[Journal]


Radical Pericardiectomy for Pericardial Diseases.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue/Desk J4-1, Cleveland, OH, 44195, USA.

Purpose Of Review: The surgical management of constrictive pericarditis has evolved from a partial pericardiectomy via a thoracotomy approach to a more extensive removal of the pericardium. This review summarizes the published studies regarding surgical management of pericardial disease, focusing on the surgical technique of radical pericardiectomy for constrictive pericarditis.

Recent Findings: Anterior phrenic to phrenic resection without the use of cardiopulmonary bypass has been performed in many centers. Read More

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http://dx.doi.org/10.1007/s11886-019-1092-1DOI Listing
February 2019
1 Read

Echocardiographic Findings in Cardiac Amyloidosis: Inside Two-Dimensional, Doppler, and Strain Imaging.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Clinical and Experimental Medicine Department, Cardiology Unit, University of Messina, Azienda Ospedaliera Universitaria 'Policlinico G. Martino,' Via Consolare Valeria 1, 98125, Messina, Italy.

Purpose Of Review: The aim is to provide a description of the most important echocardiographic features in systemic amyloidosis.

Recent Findings: Amyloidosis is a heterogeneous group of multisystem disorders, characterized by an extracellular deposition of amyloid fibrils. Several imaging tests are available for the diagnosis; however, echocardiography is the cornerstone of the non-invasive imaging modality for cardiac amyloidosis. Read More

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http://dx.doi.org/10.1007/s11886-019-1094-zDOI Listing
February 2019

Chagas Cardiomyopathy in Latin America Review.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Messejana Heart and Lung Hospital Dr. Carlos Alberto Studart Gomes, Av. Frei Cirilo, 3480 Messejana, Fortaleza, CE, 60.846-190, Brazil.

Purpose Of Review: Chagas cardiomyopathy is a major public health disease in Latin America and, due to migration, is becoming a worldwide health and economic burden. This review sought to present the clinical and epidemiological aspects of Chagas cardiomyopathy, as well as some specific features and principles of treatment. We also retrospectively assessed our institutional experience with mechanical circulatory support in refractory heart failure due to Chagas cardiomyopathy over a 10-year period. Read More

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http://dx.doi.org/10.1007/s11886-019-1095-yDOI Listing
February 2019
1 Read

Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention after Acute Coronary Syndromes: a Review.

Curr Cardiol Rep 2019 Jan 28;21(1). Epub 2019 Jan 28.

Department of Internal Medicine, Texas Tech University Health Sciences Center. Paul L. Foster School of Medicine, 4800 Alberta Avenue, El Paso, TX, 79905, USA.

Purpose Of Review: As the management of acute coronary syndrome (ACS) continues to evolve, many old practices proved to be of a little benefit and other approaches established the new pillars of modern medicine. Treating ACS patients with dual antiplatelet therapy (DAPT) for a year by combining aspirin and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) has resulted in better outcomes and is currently the standard of therapy. However, owing to the persistent activation of the coagulation cascade, patients may continue to experience recurrent ischemia and high mortality rates despite compliance with the dual antiplatelet therapy. Read More

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http://link.springer.com/10.1007/s11886-019-1088-x
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http://dx.doi.org/10.1007/s11886-019-1088-xDOI Listing
January 2019
7 Reads

Is Hemispheric Hypoperfusion a Treatable Cause of Cognitive Impairment?

Curr Cardiol Rep 2019 Jan 19;21(1). Epub 2019 Jan 19.

Department of Neurology, University of Alabama at Birmingham, 1720 7th Ave S-SC 650, Birmingham, AL, 35294, USA.

Purpose Of Review: To review the current literature that supports the notion that cerebral hemodynamic compromise from internal carotid artery stenosis may be a cause of vascular cognitive impairment that is amenable to treatment by revascularization.

Recent Findings: Converging evidence suggests that successful carotid endarterectomy and carotid artery stenting are associated with reversal of cognitive decline in many patients with severe but asymptomatic carotid artery stenosis. Most of these findings have been derived from cohort studies and comparisons with either normal or surgical controls. Read More

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http://dx.doi.org/10.1007/s11886-019-1089-9DOI Listing
January 2019
1 Read

Advances in Antiplatelet and Anticoagulant Therapies for NSTE-ACS.

Curr Cardiol Rep 2019 Jan 12;21(1). Epub 2019 Jan 12.

Department of Internal Medicine, Duke University Health System, 2301 Erwin Rd, Durham, NC, 27707, USA.

The treatment of patients requiring anticoagulation who develop acute coronary syndrome (ACS) and/or require percutaneous coronary intervention (PCI) must balance the reduction in major adverse cardiovascular events, stroke, and major bleeding. The development of direct oral anticoagulants (DOACs) for the treatment of atrial fibrillation has ushered in an era of potential treatment options for these complex patients. PURPOSE OF REVIEW: To review the clinical evidence underlying the use of DOACs for the treatment of patients with atrial fibrillation and ACS or PCI. Read More

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http://dx.doi.org/10.1007/s11886-019-1090-3DOI Listing
January 2019
2 Reads

Outcomes of New-Generation Drug-Eluting Stents in Women with Acute Myocardial Infarction.

Authors:
Subrata Kar

Curr Cardiol Rep 2019 Jan 10;21(1). Epub 2019 Jan 10.

Division of Cardiovascular Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 4800 Alberta Ave, El Paso, TX, 79905, USA.

Purpose Of Review: This review discusses the outcomes of percutaneous coronary intervention (PCI) in women who experience acute myocardial infarction (AMI) and are treated with drug-eluting stents (DES). The review also describes the role of the new-generation DES compared with the early generation.

Recent Findings: Recent literature shows that the new-generation DES can be effective in women who present with AMI. Read More

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http://link.springer.com/10.1007/s11886-019-1087-y
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http://dx.doi.org/10.1007/s11886-019-1087-yDOI Listing
January 2019
4 Reads

Genetic Risk, Adherence to a Healthy Lifestyle, and Ischemic Heart Disease.

Curr Cardiol Rep 2019 Jan 10;21(1). Epub 2019 Jan 10.

Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA.

Purpose Of Review: The purpose of this review is to investigate and discuss two aspects of coronary artery disease (CAD)-genetic risk and therapeutic lifestyle change (TLC)-both of which have key importance for patients and their care but which actually receive inadequate attention.

Recent Findings: Genetic risk has generally been relegated to a broad association with the presence of one or more inherited cardiovascular (CV) risk factors such as hypercholesterolemia, family history of atherosclerosis, hypertension, and diabetes mellitus. However, the future of genetic risk is an understanding of specific genes, a genetic risk score, specific genetic loci known as selective nucleotide polymorphisms (SNPs), specific alleles, and microribonucleic acids (miRNAs). Read More

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http://dx.doi.org/10.1007/s11886-019-1086-zDOI Listing
January 2019
3 Reads

The Role of Cardiovascular Magnetic Resonance for Surveillance of Cardiac Performance upon Receipt of Potentially Cardiotoxic Cancer Therapeutics.

Curr Cardiol Rep 2018 Oct 26;20(12):142. Epub 2018 Oct 26.

Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose Of Review: Advancements in cancer treatment have resulted in improved cancer-related survival and consequently an increase in the number of cancer survivors. Unfortunately, associated with this increase in cancer-related survivorship, cardiac events have occurred with increasing frequency in cancer survivors. Recognition that cancer survivors are at increased risk for cardiovascular (CV) morbidity has generated interest to develop cardiac imaging techniques that identify subclinical CV disease during receipt of potentially cardiotoxic cancer treatment. Read More

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http://link.springer.com/10.1007/s11886-018-1075-7
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http://dx.doi.org/10.1007/s11886-018-1075-7DOI Listing
October 2018
17 Reads

Refractory In-Stent Restenosis: Improving Outcomes by Standardizing Our Approach.

Curr Cardiol Rep 2018 Oct 22;20(12):140. Epub 2018 Oct 22.

Section of Interventional Cardiology, MedStar Washington Hospital Center, 110 Irving St., NW, Suite 4B-1, Washington, DC, 20010, USA.

Purpose Of Review: This review will focus on our approach for the treatment of refractory in-stent restenosis.

Recent Findings: The discovery of bare metal stents over three decades ago set a milestone in the evolution of percutaneous coronary intervention, which is currently the most widely performed procedure for the treatment of symptomatic coronary disease. However, the broad utilization of stents resulted in the new phenomenon of in-stent restenosis (ISR). Read More

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http://link.springer.com/10.1007/s11886-018-1076-6
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http://dx.doi.org/10.1007/s11886-018-1076-6DOI Listing
October 2018
7 Reads

Chronic Total Occlusion Interventions: Update on Current Tips and Tricks.

Curr Cardiol Rep 2018 Oct 22;20(12):141. Epub 2018 Oct 22.

Minneapolis Heart Institute, Abbott Northwestern Hospital, 920 E 28th Street #300, Minneapolis, MN, 55407, USA.

Purpose Of Review: To summarize novel techniques and developments in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).

Recent Findings: Using an algorithmic, step-by-step approach can help overcome several complex CTO lesions subsets, such as proximal cap ambiguity, ostial location, in-stent occlusion, bifurcations, balloon uncrossable and undilatable lesions. Similarly, an algorithmic approach can help prevent and optimally treat CTO PCI-related complication, such as perforation, radiation, and contrast-induced nephropathy. Read More

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http://link.springer.com/10.1007/s11886-018-1083-7
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http://dx.doi.org/10.1007/s11886-018-1083-7DOI Listing
October 2018
10 Reads

Machine Meets Biology: a Primer on Artificial Intelligence in Cardiology and Cardiac Imaging.

Curr Cardiol Rep 2018 Oct 18;20(12):139. Epub 2018 Oct 18.

University of Maryland School of Medicine, Baltimore, MD, USA.

Purpose Of Review: An understanding of the basics concepts of deep learning can be helpful in not only understanding the potential applications of this technique but also in critically reviewing literature in which neural networks are utilized for analysis and modeling.

Recent Findings: The term "deep learning" has been applied to a subset of machine learning that utilizes a "neural network" and is often used interchangeably with "artificial intelligence." It has been increasingly utilized in healthcare for computational "learning", especially for pattern recognition for diagnostic imaging. Read More

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http://link.springer.com/10.1007/s11886-018-1074-8
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http://dx.doi.org/10.1007/s11886-018-1074-8DOI Listing
October 2018
23 Reads

How Genomics Is Personalizing the Management of Dyslipidemia and Cardiovascular Disease Prevention.

Curr Cardiol Rep 2018 Oct 17;20(12):138. Epub 2018 Oct 17.

Section of Cardiology, The University of Chicago Medicine, 5841 S Maryland Avenue, MC 6080, Chicago, IL, 60637, USA.

Purpose Of The Review: To summarize advances in genomic medicine and anticipated future directions to improve cardiovascular risk reduction.

Recent Findings: Mendelian randomization and genome-wide association studies have given significant insights into the role of genetics in dyslipidemia and cardiovascular disease (CVD), with over 160 gene loci found to be associated with coronary artery disease to date. This has enabled the creation of genetic risk scores that have demonstrated improved risk prediction when added to clinical markers of CVD risk. Read More

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http://link.springer.com/10.1007/s11886-018-1079-3
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http://dx.doi.org/10.1007/s11886-018-1079-3DOI Listing
October 2018
10 Reads

The Impact of Diet and Lifestyle on Atrial Fibrillation.

Curr Cardiol Rep 2018 Oct 12;20(12):137. Epub 2018 Oct 12.

The Department of Cardiology, Royal Melbourne Hospital and the Department of Medicine, University of Melbourne, Melbourne, 3050, Australia.

Purpose Of Review: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans, affecting more than 33 million people globally. Its association with complex, resource intensive medical conditions such as stroke, heart failure and dementia have had profound impacts across existing health care structures. The global prevalence of AF has enjoyed significant growth despite significant improvement in our armamentarium for arrhythmia treatment. Read More

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http://link.springer.com/10.1007/s11886-018-1082-8
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http://dx.doi.org/10.1007/s11886-018-1082-8DOI Listing
October 2018
2 Reads

Psychosocial Stressors at Work and Ambulatory Blood Pressure.

Curr Cardiol Rep 2018 Oct 11;20(12):127. Epub 2018 Oct 11.

Department of Medicine, Laval University, 1050 Avenue de la Médecine Université Laval, Quebec, Quebec, G1V 0A6, Canada.

Purpose Of Review: Psychosocial stressors at work from the demand-latitude and effort-reward imbalance models are adverse exposures affecting about 20-25% of workers in industrialized countries. This review aims to summarize evidence on the effect of these stressors on blood pressure (BP).

Recent Findings: Three systematic reviews have recently documented the effect of these psychosocial stressors at work on BP. Read More

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http://link.springer.com/10.1007/s11886-018-1070-z
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http://dx.doi.org/10.1007/s11886-018-1070-zDOI Listing
October 2018
10 Reads

Neural Mechanisms Linking Emotion with Cardiovascular Disease.

Curr Cardiol Rep 2018 Oct 11;20(12):128. Epub 2018 Oct 11.

Department of Psychology, University of Pittsburgh, 210 South Bouquet Street, Pittsburgh, PA, 15260, USA.

Purpose Of Review: The present review discusses brain circuits that are engaged by negative emotions and possibly linked to cardiovascular disease risk. It describes recent human brain imaging studies that relate activity in these brain circuits to emotional processes, peripheral physiology, preclinical pathophysiology, as well as clinical outcomes.

Recent Findings: Negative emotions and the regulation of negative emotions reliably engage several brain regions that cross-sectional and longitudinal brain imaging studies have associated with CVD risk markers and outcomes. Read More

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http://link.springer.com/10.1007/s11886-018-1071-y
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http://dx.doi.org/10.1007/s11886-018-1071-yDOI Listing
October 2018
2 Reads

Short- and Long-term Mortality Risk After Acute Pulmonary Embolism.

Curr Cardiol Rep 2018 Oct 11;20(12):135. Epub 2018 Oct 11.

College of Medicine and Life Sciences, University of Toledo, Toledo, OH, 43614, USA.

Purpose Of Review: Acute pulmonary embolism is a major cause of morbidity and mortality in the USA and throughout the world. This review will summarize recent developments in short- and long-term mortality risk assessment after an acute pulmonary embolism.

Recent Findings: Recent guidelines have emphasized risk stratification of acute PE patients on the basis of blood pressure, right ventricular size, and biomarker status. Read More

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http://link.springer.com/10.1007/s11886-018-1084-6
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http://dx.doi.org/10.1007/s11886-018-1084-6DOI Listing
October 2018
2 Reads

Diabetic Dyslipidemia: Epidemiology and Prevention of Cardiovascular Disease and Implications of Newer Therapies.

Curr Cardiol Rep 2018 Oct 11;20(12):125. Epub 2018 Oct 11.

Division of Cardiology, Kaiser Permanente Medical Center, 3600 Broadway, Oakland, CA, 94611, USA.

Purpose Of Review: Dyslipidemia in patients with T2DM confers significant additional risk of adverse outcomes to patients with cardiovascular disease (CVD). These patients carry residual risk of adverse outcomes despite optimal management with conventional therapy such as lifestyle changes and statin therapy. The role of both nonstatin monotherapy in statin-intolerant patients and combination therapy with statins in patients with high risk of CVD events has been well studied. Read More

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http://link.springer.com/10.1007/s11886-018-1068-6
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http://dx.doi.org/10.1007/s11886-018-1068-6DOI Listing
October 2018
4 Reads

Challenges in Aortic Stenosis: Review of Antiplatelet/Anticoagulant Therapy Management with Transcatheter Aortic Valve Replacement (TAVR): TAVR with Recent PCI, TAVR in the Patient with Atrial Fibrillation, and TAVR Thrombosis Management.

Curr Cardiol Rep 2018 Oct 11;20(12):130. Epub 2018 Oct 11.

Duke Clinical Research Institute, 2400 Pratt Street, P.O. Box 17969, Durham, NC, 27715, USA.

Purpose Of Review: This review aims to describe the current evidence and consensus recommendations around antiplatelet and anticoagulant management in three common clinical scenarios in transcatheter aortic valve replacement (TAVR): (1) recent percutaneous coronary intervention (PCI) preceding TAVR, (2) atrial fibrillation (AF) management in patients undergoing TAVR, and (3) bioprosthetic valve thrombosis management in TAVR.

Recent Findings: Several small clinical trials have evaluated the use of single vs. dual antiplatelet therapy in patients undergoing TAVR, with most recent data favoring single antiplatelet therapy. Read More

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http://link.springer.com/10.1007/s11886-018-1073-9
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http://dx.doi.org/10.1007/s11886-018-1073-9DOI Listing
October 2018
17 Reads

Modern Approaches to Evacuating Intracerebral Hemorrhage.

Curr Cardiol Rep 2018 Oct 11;20(12):132. Epub 2018 Oct 11.

Department of Neurology, University of Missouri, 1 Hospital Drive, DC047.00, Columbia, MO, 65212, USA.

Purpose Of Review: The present review aims to discuss the recent advances in surgical management of spontaneous intracerebral hemorrhage (ICH), safety and efficacy of minimally invasive surgical techniques, and the existing evidence supporting their use.

Recent Findings: Newer surgical techniques, collectively referred to as minimally invasive surgery (MIS), have been evaluated and studied in management of ICH. Stereotactic evacuation of intracerebral hemorrhage using aspiration-irrigation technique has showed significant reductions in the hematoma volume with minimal intra-operative bleeding. Read More

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http://link.springer.com/10.1007/s11886-018-1078-4
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http://dx.doi.org/10.1007/s11886-018-1078-4DOI Listing
October 2018
7 Reads

Diagnosis and Management of Chagas Cardiomyopathy in the United States.

Curr Cardiol Rep 2018 Oct 11;20(12):131. Epub 2018 Oct 11.

Smidt Heart Institute, Cedars-Sinai Medical Center, 8536 Wilshire Blvd #302, Beverly Hills, CA, 90211, USA.

Purpose Of Review: Chagas cardiomyopathy is an emerging form of non-ischemic cardiomyopathy in the USA. This review aims to summarize current concepts in pathophysiology, disease transmission, medical therapy, and heart transplantation for patients with chronic Chagas cardiomyopathy.

Recent Findings: The incidence of Chagas cardiomyopathy is increasing in the USA, driven mainly by immigration from countries where Chagas disease is endemic. Read More

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http://dx.doi.org/10.1007/s11886-018-1077-5DOI Listing
October 2018
9 Reads

Asymptomatic Severe Aortic Valve Stenosis-When to Intervene: a Review of the Literature, Current Trials, and Guidelines.

Curr Cardiol Rep 2018 Oct 11;20(12):129. Epub 2018 Oct 11.

Division of Cardiology, Duke University Hospital, Durham, NC, USA.

Purpose Of Review: The optimal treatment for asymptomatic patients with severe aortic valve stenosis (AS) is not clearly known. Here, we review the available data on the management of such patients.

Recent Findings: Half of patients with severe AS are asymptomatic at the time of diagnosis, and are at risk for adverse events, including sudden cardiac death. Read More

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http://link.springer.com/10.1007/s11886-018-1072-x
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http://dx.doi.org/10.1007/s11886-018-1072-xDOI Listing
October 2018
3 Reads

Assessing Performance and Quality After Non-ST Segment Elevation Acute Coronary Syndromes.

Curr Cardiol Rep 2018 Oct 11;20(12):133. Epub 2018 Oct 11.

Cardiology Division, University of Texas Health Science Center, McGovern Medical School, Memorial Hermann Heart & Vascular Institute, 6431 Fannin, MSB-1.246, Houston, TX, 77030, USA.

Purpose Of Review: This review summarizes and discusses the evidence base supporting current performance and quality measures used in assessing institutions in their care of patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS).

Recent Findings: Professional societies in the USA and Europe have developed performance and quality measures for NSTE-ACS. These measures are reviewed and updated periodically to reflect the most important evidence from the literature. Read More

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http://link.springer.com/10.1007/s11886-018-1081-9
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http://dx.doi.org/10.1007/s11886-018-1081-9DOI Listing
October 2018
2 Reads

Building an Adult Congenital Heart Program: Critical Components and Important Allies.

Curr Cardiol Rep 2018 Oct 11;20(12):134. Epub 2018 Oct 11.

Houston Methodist DeBakey Heart & Vascular Center, 6550 Fannin Street, Suite 1901, Houston, TX, 77030, USA.

Purpose Of The Review: The purpose of this review is to illustrate specific challenges and opportunities in the building of an adult congenital heart disease (ACHD) program and to highlight critical components and important allies.

Recent Findings: With more than 1.4 million adults with congenital heart disease in the USA alone, access to specialized, compassionate, high-quality comprehensive care requires a shift toward more aggressive expansion of ACHD care, especially in the context of sparse ACHD provider representation in the vast majority of adult medical centers. Read More

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http://dx.doi.org/10.1007/s11886-018-1080-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267382PMC
October 2018
17 Reads

Role of Echocardiography in Assessment of Cardioembolic Sources: a Strong Diagnostic Resource in Patients with Ischemic Stroke.

Curr Cardiol Rep 2018 Oct 11;20(12):136. Epub 2018 Oct 11.

Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, 2801 W. Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI, 53215, USA.

Purpose Of Review: This review will discuss the most frequent sources of cardiac embolism and the role of echocardiography in these different clinical settings, and, in addition, provide suggestions about the choice between transthoracic (TTE) and transesophageal echocardiography (TEE).

Recent Findings: Stroke is the third leading cause of death in industrial countries, and 15-40% of all ischemic strokes are due to cardioembolism. TTE and TEE are cornerstones in the detection of cardioembolic sources and provide fundamental information about the embolic risk and most suitable treatment of these patients, improving long-term outcomes. Read More

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http://link.springer.com/10.1007/s11886-018-1085-5
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http://dx.doi.org/10.1007/s11886-018-1085-5DOI Listing
October 2018
14 Reads

The Evolving Cardiovascular Disease Risk Scores for Persons with Diabetes Mellitus.

Curr Cardiol Rep 2018 Oct 11;20(12):126. Epub 2018 Oct 11.

Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, 650 Charles E Young Drive, Los Angeles, CA, 90095, USA.

Purpose Of Review: We briefly introduce the concept and use of cardiovascular disease (CVD) risk scores and review the methodology for CVD risk score development and validation in patients with diabetes. We also discuss CVD risk scores for diabetic patients that have been developed in different countries.

Recent Findings: Patients with diabetes have a gradient of CVD risk that needs to be accurately assessed. Read More

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http://link.springer.com/10.1007/s11886-018-1069-5
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http://dx.doi.org/10.1007/s11886-018-1069-5DOI Listing
October 2018
12 Reads

Role of Percutaneous Chronic Total Occlusion Interventions in Patients with Ischemic Cardiomyopathy and Reduced Left Ventricular Ejection Fraction.

Curr Cardiol Rep 2018 Oct 1;20(11):124. Epub 2018 Oct 1.

Division of Cardiology, Medical College of Virginia/VCU School of Medicine, Virginia Commonwealth University, 1200 East Broad St, 5th Floor-West wing, Room #526, Richmond, VA, 23298, USA.

Purpose Of Review: The purpose of this review is to examine current evidence on the benefit of chronic total occlusion (CTO) revascularization in patients with ischemic cardiomyopathy and propose a systematic approach on how and when to accomplish revascularization in these patients.

Recent Findings: Coronary revascularization in patients with reduced ejection fraction (EF) is advocated for to improve left ventricular function and consequently clinical outcomes. Approximately 16-31% of angiograms in patients with advanced CAD are noted to have a concomitant coronary CTO. Read More

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http://dx.doi.org/10.1007/s11886-018-1066-8DOI Listing
October 2018
1 Read

Long Working Hours and Risk of Cardiovascular Disease.

Curr Cardiol Rep 2018 Oct 1;20(11):123. Epub 2018 Oct 1.

Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 7 HB, UK.

Purpose Of Review: To summarize the evidence on the relationship between long working hours and cardiovascular disease, such as coronary heart disease and stroke.

Recent Findings: Large-scale meta-analyses with published and individual participant observational data on more than 740,000 men and women free of cardiovascular disease report a link between long working hours (≥ 55 h a week) and the onset of cardiovascular events. Our meta-analytic update of summary evidence suggests a 1. Read More

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http://link.springer.com/10.1007/s11886-018-1049-9
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http://dx.doi.org/10.1007/s11886-018-1049-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267375PMC
October 2018
15 Reads

What Is the Clinical Utility of Intravascular Ultrasound?

Curr Cardiol Rep 2018 Sep 28;20(11):122. Epub 2018 Sep 28.

Section of Cardiology, University of Chicago Medicine, 5841 South Maryland Avenue, MC 5076, Chicago, IL, 60637, USA.

Purpose Of Review: This article reviews the contemporary evidence base for use of coronary intravascular ultrasound (IVUS).

Recent Findings: Recent studies have strongly associated IVUS guidance during percutaneous coronary angioplasty (PCI) with lower major adverse cardiac events (MACE), stent thrombosis, and in selected groups, mortality. The PROSPECT study found in acute coronary syndromes patients, IVUS-determined minimal luminal area ≤ 4. Read More

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http://link.springer.com/10.1007/s11886-018-1062-z
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http://dx.doi.org/10.1007/s11886-018-1062-zDOI Listing
September 2018
10 Reads

Dangers of Overly Aggressive Blood Pressure Control.

Curr Cardiol Rep 2018 Sep 26;20(11):108. Epub 2018 Sep 26.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 524C, Baltimore, MD, 21287, USA.

Purpose Of Review: Recent US guidelines have changed the definition of hypertension to ≥ 130/80 mmHg and recommended more intense blood pressure (BP) targets. We summarize the evidence for intense BP treatment and discuss risks that must be considered when choosing treatment goals for individual patients.

Recent Findings: The SPRINT study reported that treating to a systolic BP target of 120 mmHg reduces cardiovascular outcomes in high-risk individuals, supporting more intensive BP reduction than previously recommended. Read More

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http://link.springer.com/10.1007/s11886-018-1063-y
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http://dx.doi.org/10.1007/s11886-018-1063-yDOI Listing
September 2018
4 Reads

Role of Cardiac Magnetic Resonance Imaging in Valvular Heart Disease: Diagnosis, Assessment, and Management.

Curr Cardiol Rep 2018 Sep 26;20(11):119. Epub 2018 Sep 26.

Department of Medicine (Cardiovascular Division), University of Virginia Health System, 1215 Lee Street, PO Box 800158, Charlottesville, VA, 22908, USA.

Purpose Of Review: This article will review the current techniques in cardiac magnetic resonance imaging (CMR) for diagnosing and assessing primary valvular heart disease.

Recent Findings: The recent advancements in CMR have led to an increased role of this modality for qualifying and quantifying various native valve diseases. Phase-contrast velocity encoded imaging is a well-established technique that can be used to quantify aortic and pulmonic flow. Read More

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http://dx.doi.org/10.1007/s11886-018-1057-9DOI Listing
September 2018
10 Reads

Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Risk Reduction in Type 2 Diabetes Mellitus: Is It a Class Effect?

Curr Cardiol Rep 2018 Sep 26;20(11):113. Epub 2018 Sep 26.

Dept. of Medicine, Div. Endocrinology, Diabetes & Metabolism, University California, Irvine, School of Medicine, Irvine, CA, USA.

Purpose Of Review: Mimetics and analogs that extend the half-life of native glucagon-like peptide-1 (GLP-1), i.e., glucagon-like peptide-1 receptor agonists (GLP-1 RAs), at therapeutic doses, are indicated as adjuncts to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.1007/s11886-018-1051-2DOI Listing
September 2018
1 Read

Echocardiography in Sarcoidosis.

Curr Cardiol Rep 2018 Sep 26;20(11):118. Epub 2018 Sep 26.

Department of Cardiology, Mayo Clinic, Rochester, MN, USA.

Purpose Of Review: Cardiac sarcoidosis (CS) is associated with significant morbidity and mortality. The diagnosis of CS is challenging and typically one that is only entertained after many other conditions have been ruled out. A high index of suspicion is necessary in order to correctly determine appropriate testing for the disease. Read More

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http://link.springer.com/10.1007/s11886-018-1065-9
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http://dx.doi.org/10.1007/s11886-018-1065-9DOI Listing
September 2018
4 Reads

Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction.

Curr Cardiol Rep 2018 Sep 26;20(11):116. Epub 2018 Sep 26.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Casorati 43, 37100, Verona, Italy.

Purpose Of Review: This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.

Recent Findings: The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. Read More

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http://link.springer.com/10.1007/s11886-018-1056-x
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http://dx.doi.org/10.1007/s11886-018-1056-xDOI Listing
September 2018
12 Reads

Prevention of Heart Failure in Patients with Diabetes: Role of Diabetes Medications.

Curr Cardiol Rep 2018 Sep 26;20(11):112. Epub 2018 Sep 26.

UCLA Division of Cardiology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Purpose Of Review: Type 2 diabetes mellitus (DM) is a major risk factor for the development of heart failure (HF). In patients with DM, preventing HF using diabetes medications should be an imperative for primary care physicians and cardiologists alike.

Recent Findings: Prior studies with DPP-IV inhibitors, thiazolidinediones (TZDs), and GLP-1 agonists have demonstrated either a neutral effect on HF or increased HF hospitalizations. Read More

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http://dx.doi.org/10.1007/s11886-018-1050-3DOI Listing
September 2018
2 Reads

Pulmonary Embolism for the Cardiologist: Emphasis on Diagnosis.

Curr Cardiol Rep 2018 Sep 26;20(11):120. Epub 2018 Sep 26.

Department of Medicine, Division of Hematology Oncology, University of Vermont, University of Vermont Medical Center, Burlington, VT, USA.

Purpose Of Review: Pulmonary embolism (PE) is a common condition with high morbidity and mortality particularly if misdiagnosed or untreated. It has non-specific clinical manifestations, often presenting similarly to other cardiovascular conditions. The aim of this review is to summarize the clinical presentation, diagnostic algorithms, and imaging studies utilized to efficiently make or exclude the diagnosis of pulmonary embolism. Read More

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http://link.springer.com/10.1007/s11886-018-1060-1
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http://dx.doi.org/10.1007/s11886-018-1060-1DOI Listing
September 2018
5 Reads

His-Bundle Pacing and LV Endocardial Pacing as Alternatives to Traditional Cardiac Resynchronization Therapy.

Curr Cardiol Rep 2018 Sep 26;20(11):109. Epub 2018 Sep 26.

Division of Cardiac Electrophysiology, Geisinger Heart Institute, MC 36-10, 1000 E Mountain Blvd, Wilkes-Barre, PA, 18711, USA.

Purpose Of Review: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is the cornerstone of treatment for patients with heart failure and left bundle branch block. Up to a third of patients do not respond to BVP. This article reviews the utility of His-bundle pacing (HBP) and Left ventricular (LV) endocardial pacing as alternatives to BVP to provide ventricular synchrony. Read More

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http://dx.doi.org/10.1007/s11886-018-1046-zDOI Listing
September 2018
1 Read

The Utility of Rodent Models of Stress for Disentangling Individual Vulnerability to Depression and Cardiovascular Comorbidity.

Curr Cardiol Rep 2018 Sep 26;20(11):111. Epub 2018 Sep 26.

Department of Chemistry, Stress Physiology Lab, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124, Parma, Italy.

Purpose Of Review: This review offers a perspective of the utility of rodent models of stress for identifying sources of individual vulnerability to depression and cardiovascular disease comorbidity.

Recent Findings: Differential stress susceptibility is found in rodents exposed to repeated social defeat as a function of their coping style. Specifically, passive coping rodents show an increase in inflammatory processes within the brain that favour the development of depressive-like symptoms and cardiovascular abnormalities. Read More

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http://dx.doi.org/10.1007/s11886-018-1064-xDOI Listing
September 2018
1 Read

Tumor Necrosis Factor-α in Heart Failure: an Updated Review.

Curr Cardiol Rep 2018 Sep 26;20(11):117. Epub 2018 Sep 26.

NB50, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Purpose Of The Review: Proinflammatory cytokines are consistently elevated in congestive heart failure. In the current review, we provide an overview on the current understanding of how tumor necrosis factor-α (TNFα), a key proinflammatory cytokine, potentiates heart failure by overwhelming the anti-inflammatory responses disrupting the homeostasis.

Recent Findings: Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers. Read More

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http://dx.doi.org/10.1007/s11886-018-1067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311126PMC
September 2018
1 Read

Management of Anticoagulation in Patients with Atrial Fibrillation Undergoing PCI: Double or Triple Therapy?

Curr Cardiol Rep 2018 Sep 26;20(11):110. Epub 2018 Sep 26.

Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose Of Review: This review aims to discuss the use of antithrombotic therapy in patients with atrial fibrillation who undergo coronary stenting with emphasis on the use of double vs triple therapy.

Recent Findings: When combined with systemic anticoagulation, dual antiplatelet therapy results in an unacceptable increase in bleeding without any improvement in prevention of thrombotic events. Direct oral anticoagulants combined with single antiplatelet therapy have reduced bleeding compared with warfarin plus dual antiplatelet therapy. Read More

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http://dx.doi.org/10.1007/s11886-018-1045-0DOI Listing
September 2018
2 Reads

Genetics of Dilated Cardiomyopathy.

Curr Cardiol Rep 2018 Sep 27;20(11):121. Epub 2018 Sep 27.

Cardiac Transplant, Mechanical Circulatory Support and Advanced Heart Failure Programs, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, 17033, USA.

Purpose Of Review: Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation and systolic function and is the most common among all cardiomyopathies. Familial DCM makes up a significant portion of cases, and approximately 40 genes are identified as involved in the pathogenesis of heart failure, each affecting a specific part of cellular mechanisms. The purpose of this review is to summarize recent findings and the current understanding of the most common gene mutations identified associated with DCM. Read More

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http://dx.doi.org/10.1007/s11886-018-1061-0DOI Listing
September 2018
2 Reads

Acute and Fulminant Myocarditis: a Pragmatic Clinical Approach to Diagnosis and Treatment.

Curr Cardiol Rep 2018 Sep 26;20(11):114. Epub 2018 Sep 26.

"De Gasperis" Cardio Center and Transplant Center, Niguarda Hospital, Milan, Italy.

Purpose Of Review: To review the clinical features of acute myocarditis, including its fulminant presentation, and present a pragmatic approach to the diagnosis and treatment, considering indications of American and European Scientific Statements and recent data derived by large contemporary registries.

Recent Findings: Patients presenting with acute uncomplicated myocarditis (i.e. Read More

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http://dx.doi.org/10.1007/s11886-018-1054-zDOI Listing
September 2018
3 Reads

Non-coding RNA in Ischemic and Non-ischemic Cardiomyopathy.

Curr Cardiol Rep 2018 Sep 26;20(11):115. Epub 2018 Sep 26.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Purpose Of Review: This review aims to summarize and discuss the function and molecular mechanism of miRNA and lncRNA in the heart, focusing on ischemic and non-ischemic cardiomyopathy.

Recent Findings: Extensive studies in the past decades have identified numerous protein-coding genes that are highly expressed in the heart, playing essential roles in the regulation of cardiac gene expression, heart development, and function. Furthermore, mutations in many of these genes have been identified and are linked to cardiovascular disease. Read More

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http://dx.doi.org/10.1007/s11886-018-1055-yDOI Listing
September 2018
1 Read

Is There Still a Role for Digoxin in the Management of Atrial Fibrillation?

Curr Cardiol Rep 2018 Sep 12;20(11):105. Epub 2018 Sep 12.

Division of Cardiology, Duke University School of Medicine, Duke Clinical Research Institute, Duke Heart Center, Durham, NC, USA.

Purpose Of Review: A number of recent observational analyses have assessed clinical outcomes associated with digoxin use in patients with atrial fibrillation. In this review, we review these data and provide suggestions on the contemporary use of digoxin in patients with atrial fibrillation as supported by the recent evidence.

Recent Findings: Observational data from clinical trials and registries have provided variable results on the safety and efficacy of chronic digoxin use in patients with atrial fibrillation. Read More

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http://dx.doi.org/10.1007/s11886-018-1047-yDOI Listing
September 2018
9 Reads

Type D Personality as a Risk Factor in Coronary Heart Disease: a Review of Current Evidence.

Curr Cardiol Rep 2018 Sep 12;20(11):104. Epub 2018 Sep 12.

Center of Research on Psychology in Somatic Diseases, Tilburg University, PO box 90153, 5000 LE, Tilburg, The Netherlands.

Purpose Of The Review: This review article synthesizes recent research findings on the psychological context of Type D personality and the mechanisms through which Type D affects disease progression and prognosis among patients with coronary heart disease (CHD).

Recent Findings: One in four patients with CHD has a Distressed (Type D) personality, which is characterized by two stable traits: social inhibition and negative affectivity. Type D personality predicts increased mortality and morbidity burden, and poorer health-related quality of life. Read More

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http://link.springer.com/10.1007/s11886-018-1048-x
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http://dx.doi.org/10.1007/s11886-018-1048-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153564PMC
September 2018
9 Reads

Transcatheter Mitral Valve Therapy: Defining the Patient Who Will Benefit.

Curr Cardiol Rep 2018 Sep 12;20(11):107. Epub 2018 Sep 12.

Center for Structural Heart Disease, Henry Ford Hospital, 2799 W. Grand Blvd, Detroit, MI, 48202, USA.

Purpose Of Review: This report aims to define the clinical and anatomic variables key in determining patient suitability for transcatheter mitral valve therapies.

Recent Findings: Candidacy for transcatheter mitral valve repair requires weighing the clinical variables that may impact the ability to improve patient symptoms and prolong survival that include left ventricular ejection fraction, symptom severity, pulmonary hypertension, and magnitude of residual regurgitation or stenosis. Individualized selection of transcatheter repair or replacement based on patho-anatomy is being explored. Read More

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http://dx.doi.org/10.1007/s11886-018-1058-8DOI Listing
September 2018
3 Reads

Atrial Cardiopathy and Stroke Prevention.

Curr Cardiol Rep 2018 Sep 12;20(11):103. Epub 2018 Sep 12.

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Purpose Of Review: Many patients with ischemic stroke have a stroke syndrome and neuroimaging findings consistent with embolism, but no evidence of atrial fibrillation. Recent data suggest that the pathological atrial substrate, or atrial cardiopathy, that underlies atrial fibrillation, rather than atrial fibrillation itself, may be an important cause of unexplained strokes. This paper will review the literature on the rationale and data behind the concept of atrial cardiopathy, its pathophysiology, suggested biomarkers of atrial cardiopathy, and therapeutic implications. Read More

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http://dx.doi.org/10.1007/s11886-018-1053-0DOI Listing
September 2018
4 Reads

The Clinical Dilemma of Anticoagulation Use in Patients with Cerebral Amyloid Angiopathy and Atrial Fibrillation.

Curr Cardiol Rep 2018 Sep 12;20(11):106. Epub 2018 Sep 12.

From the Department of Neurology (RJC, JFM), Mayo Clinic in Florida, 4500 San Pablo Road, Jacksonville, FL, 32256, USA.

Purpose Of Review: This review highlights current management of patients with concomitant cerebral amyloid angiopathy (CAA) and atrial fibrillation (AF). We review quantifying risk of ischemic and hemorrhagic stroke as well as treatments to minimize future risk.

Recent Findings: Ischemic stroke risk in AF can be quantified by CHADS-VASc and assessing left atrial echocardiographic characteristics. Read More

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http://dx.doi.org/10.1007/s11886-018-1052-1DOI Listing
September 2018
3 Reads

Correction to: Update on Devices for Diastolic Dysfunction: Options for a No Option Condition?

Curr Cardiol Rep 2018 Sep 10;20(10):102. Epub 2018 Sep 10.

Janey and Dolph Briscoe Division of Cardiology, University of Texas Health Sciences Center at San Antonio, Mail Code 7872, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

In the original publication, the author name "Amit Gupta" was incorrectly spelled as "Ahmit Gupta". The original article has been corrected. Read More

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http://dx.doi.org/10.1007/s11886-018-1059-7DOI Listing
September 2018
1 Read

Treatment of Bifurcation Lesions: Has DK Crush"ed" the Competition?

Curr Cardiol Rep 2018 Sep 1;20(10):101. Epub 2018 Sep 1.

St Vincent Medical Group, St Vincent Heart Center, 10590 N Meridian, Indianapolis, IN, 46290, USA.

Purpose: This paper reviews the double-kiss crush (DK crush) technique in coronary artery bifurcation lesions. The technical aspects of the procedure and the clinical data supporting its use are summarized.

Recent Findings: Randomized studies support the adoption of DK technique in complex bifurcation lesions for both left main and non-left-main lesions. Read More

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http://dx.doi.org/10.1007/s11886-018-1024-5DOI Listing
September 2018
1 Read