16 results match your criteria Current Bioactive Compounds[Journal]

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Antiplasmodial Compounds from Leaves of .

Curr Bioact Compd 2017 Sep;13(3):268-273

Department of Chemistry, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Dodonaea angustifolia is used in Ethiopian traditional medicine to treat malaria. The objective of this work was to conduct bioassay guided fractionation of the leaves of D. angustifolia using Plasmodium berghei infected mice. Read More

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http://dx.doi.org/10.2174/1573407213666170403121222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688408PMC
September 2017
25 Reads

Protodioscin, Isolated from the Rhizome of Collected in Northern Japan is the Major Antiproliferative Compound to HL-60 
Leukemic Cells.

Curr Bioact Compd 2017 Jun;13(2):170-174

Laboratory of Bio-organic Chemistry, Akita Prefectural University, Akita, 010-0195, Japan.

Background: The rhizome of Oni-dokoro (a wild yam, Dioscorea tokoro) has extremely bitter taste and is not generally regarded edible;, however, in northern part of Japan, such as Iwate and a part of Aomori, it is used as health promoting food. To clarify the reason, we examined the biologically active compounds in the rhizome collected at Iwate and compared them from the other area in literature.

Methods: The acetonitrile extract from northern part of Japan was purified by bioassay-guided separation using antiproliferative activity to human leukemia HL-60 cell, and protodioscin (PD) was isolated and identified by instrumental analyses as the major active compound. Read More

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http://dx.doi.org/10.2174/1573407213666170113123428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396219PMC
June 2017
34 Reads

Synthesis of ST7612AA1, a Novel Oral HDAC Inhibitor, via Radical 
Thioacetic Acid Addition.

Curr Bioact Compd 2016 Dec;12(4):282-288

R&D Sigma-Tau IFR S.p.A., Via Pontina Km 30,400, I-00071 Pomezia, Rome, Italy.

Abstract Background: In the expanding field of anticancer drugs, HDAC inhibitors are playing an increasingly important role. To date, four/five HDAC inhibitors have been approved by FDA. All these compounds fit the widely accepted HDAC inhibitors pharmacophore model characterized by a cap group, a linker chain and a zinc binding group (ZBG), able to bind the Zn ion in a pocket of the HDAC active site. Read More

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http://dx.doi.org/10.2174/1573407212666160504160556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101637PMC
December 2016
29 Reads

DNA Cleaving "Tandem-Array" Metallopeptides Activated With KHSO: Towards the Development of Multi-Metallated Bioactive Conjugates and Compounds.

Curr Bioact Compd 2014 ;10(1):13-20

Department of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202.

Amino terminal peptides of the general form Gly-Gly-His have been used to introduce single sites of metal binding and redox activity into a wide range of biomolecules to create bioactive compounds and conjugates capable of substrate oxidation. We report here that Gly-Gly-His-like peptides linked in a tandem fashion can also be generated leading to multi-metal binding arrays. While metal binding by the native Gly-Gly-His motif (typically to Cu, Ni, or Co) requires a terminal peptide amine ligand, previous work has demonstrated that an ornithine (Orn) residue can be substituted for the terminal Gly residue to allow solid-phase peptide synthesis to continue via the side chain -δ. Read More

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http://dx.doi.org/10.2174/157340721001140724150901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232849PMC
January 2014
24 Reads

Bioactivities between Traditional Medicine and Chemical Extracts.

Curr Bioact Compd 2013 Dec;9(4):324-332

Department of Environmental Technology Management, College for Women, Kuwait University, Kuwait.

The present work investigates the efficacy of using in traditional medicine in comparison with chemical extracts of its bioactive molecules. In addition, the effects of location (Egypt and Jericho) on the bioactivities of the plant were investigated. The results showed that water extracts of from Jericho have stronger antibacterial activities than organic solvent extracts. Read More

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http://dx.doi.org/10.2174/157340720904140404151439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992861PMC
December 2013
13 Reads

A Cell-Cell Communication Marker for Identifying Targeted Tumor Therapies.

Curr Bioact Compd 2013 ;9(3):255-262

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University Atlanta, Georgia 30341.

Cell-cell communication through gap junctions is aberrant or absent in a majority of human cancer cells, compared to cells in corresponding normal tissues. This and other evidence has led to the hypothesis that gap junction channels, comprised of connexin proteins, are important in growth control and cancer progression. The major goal of this ongoing study was to identify bioactive compounds that specifically upregulate gap junction channel-mediated cell-cell communication as potential anti-tumor therapies. Read More

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http://dx.doi.org/10.2174/157340720903140119155322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232852PMC
January 2013
15 Reads

Effect of Soil Nutrient on Production and Diversity of Volatile Terpenoids from Plants.

Curr Bioact Compd 2012 Jan;8(1):71-79

Aix-Marseille University - Equipe Diversité et Fonctionnement : des Molécules aux Ecosystèmes - Institut Méditerranéen de Biodiversité et d'Ecologie (IMBE) (marine et continentale) UMR 7263 CNRS. Centre St Charles, Case 4, 13331 Marseille Cedex 03, France.

Terpenoid production (emission and storage) within foliage plays direct and indirect defensive and protective functions for the plant, mediates complex trophic relationships and controls the oxidation capacity of the atmosphere. Both biotic and abiotic conditions alter terpenoid production, with herbivory, light and temperature effects being reasonably well understood. In this manuscript, the state of the science about nutrient effect on terpenoid production is reviewed. Read More

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http://dx.doi.org/10.2174/157340712799828188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474957PMC
January 2012
8 Reads

Monoterpenes of Salvia leucophylla.

Curr Bioact Compd 2012 Jan;8(1):90-100

Department of Biological Sciences, Faculty of Science, Nara Women's University, Kitauoya-nishi-machi, Nara, 630-8506, Japan.

The " Salvia phenomenon" is one of the most famous examples of allelopathic interaction between higher plants. The Salvia thickets are surrounded by zones of bare soil ("bare zone", 1-3 m in width), which merge into areas of inhibited grassland ("zone of inhibition") and finally undisturbed grassland at a distance of 3-9 m. This characteristic vegetation pattern was attributed to monoterpenes, especially 1,8-cineole and camphor, which volatilized from S. Read More

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http://dx.doi.org/10.2174/157340712799828205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382373PMC
January 2012
15 Reads

Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy.

Curr Bioact Compd 2011 Sep;7(3):180-197

Eisai Research Institute, 4 Corporate drive, Andover, MA 01810.

Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. It was first identified in bacterial cell wall peptidoglycan as an active component in Freund's complete adjuvant. In the cell, MDP is detected by NOD2, a cytoplasmic receptor belonging to the human innate immune system. Read More

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http://dx.doi.org/10.2174/157340711796817913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241611PMC
September 2011
7 Reads

Antifungal Compounds from Species.

Curr Bioact Compd 2011 Dec;7(4)

Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, China.

This review documents chemical structures and antifungal activities of 68 compounds isolated from 22 species of the plant family Piperaceae. These compounds include amides, flavonoids, prenylated benzoic acid derivatives, lignans, phenylpropanoids, butenolides, and cyclopentendiones. Some of them may serve as leads for potential pharmaceutical or agricultural fungicide development. Read More

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http://dx.doi.org/10.2174/157340711798375822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845523PMC
December 2011
14 Reads

CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development.

Curr Bioact Compd 2011 Mar;7(1):8-14

Cerulean Pharma Inc., 840 Memorial Drive, Cambridge MA 02139, USA.

CRLX101 (formerly IT-101) is a first-in-class nanopharmaceutical, currently in Phase 2a development, which has been developed by covalently conjugating camptothecin (CPT) to a linear, cyclodextrin-polyethylene glycol (CD-PEG) co-polymer that self-assembles into nanoparticles. As a nanometer-scale drug carrier system, the cyclodextrin polymeric nanoparticle technology, referred to as "CDP", has unique design features and capabilities. Specifically, CRLX101 preclinical and clinical data confirm that CDP can address not only solubility, formulation, toxicity, and pharmacokinetic challenges associated with administration of CPT, but more importantly, can impart unique biological properties that enhance CPT pharmacodynamics and efficacy. Read More

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http://dx.doi.org/10.2174/157340711795163866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182091PMC
March 2011
15 Reads

Circulating and Vascular Bioactive Factors during Hypertension in Pregnancy.

Curr Bioact Compd 2010 Mar;6(1):60-75

Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.

Normal pregnancy is associated with significant vascular remodeling in the uterine and systemic circulation in order to meet the metabolic demands of the mother and developing fetus. The pregnancy-associated vascular changes are largely due to alterations in the amount/activity of vascular mediators released from the endothelium, vascular smooth muscle and extracellular matrix. The endothelium releases vasodilator substances such as nitric oxide, prostacyclin and hyperpolarizing factor as well as vasoconstrictor factors such as endothelin, angiotensin II and thromboxane A(2). Read More

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http://dx.doi.org/10.2174/157340710790711737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856945PMC
March 2010
8 Reads

Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy.

Authors:
Sherry R Chemler

Curr Bioact Compd 2009 Mar;5(1):2-19

The University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

The phenanthroindolizidine and phenanthroquinolizidine alkaloids, typified by tylophorine and cryptopleurine, are a family of plant-derived small molecules with significant therapeutic potential. The plant extracts have been used in herbal medicine and the isolated compounds have displayed a range of promising therapeutic activity such as anti-ameobicidal, anti-viral, anti-inflammatory and anti-cancer activity. Despite their therapeutic protential, no compounds in this class have fully passed clinical trials. Read More

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http://dx.doi.org/10.2174/157340709787580928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759725PMC
March 2009
9 Reads

Iron Chelators as Potential Therapeutic Agents for Parkinson's Disease.

Curr Bioact Compd 2008 Oct;4(3):150-158

Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747-2300.

Parkinson's disease (PD) is a neurological disorder characterized by the progressive impairment of motor skills in patients. Growing evidence suggests that abnormal redox-active metal accumulation, caused by dysregulation, plays a central role in the neuropathology of PD. Redox-active metals (e. Read More

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http://dx.doi.org/10.2174/157340708786305952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756717PMC
October 2008
9 Reads
8 Citations

Nanomedicine: Addressing Cardiovascular Disease and Cardiovascular Tissue Regeneration.

Curr Bioact Compd 2009 ;5(3):206-214

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22903, USA.

Cardiovascular disease is becoming an increasingly significant problem. In attempts to overcome many of the traditional hurdles of cardiovascular disease treatment, therapeutic approaches have been gradually moving beyond an exclusive focus on orally delivered drugs towards the development of nanoscale applications. These technologies exploit molecular scale events to improve drug and gene delivery applications, enhance preventative medicine and diagnostic strategies, and create biomimicking substrates for vascular tissue engineering. Read More

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http://dx.doi.org/10.2174/157340709789054722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019576PMC
January 2009
8 Reads

BIOLOGICALLY ACTIVE NATURAL PRODUCTS OF THE GENUS CALLICARPA.

Curr Bioact Compd 2008 Jun;4(1):15-32

Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, U.S.A.

About 20 species from Callicarpa have reported ethnobotanical and ethnomedical uses, and several members of this genus are well known in the traditional medical systems of China and South Asia. Ethnomedical reports indicate their use in the treatment of hepatitis, rheumatism, fever, headache, indigestion, and other ailments. Several species of Callicarpa have been reported to be used against cancer (e. Read More

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http://dx.doi.org/10.2174/157340708784533393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760847PMC
June 2008
17 Reads
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