1,126,259 results match your criteria Current Bioactive Compounds[Journal]


Deviancy, Dependency, and Disability: the Forgotten History of Eugenics and Mass Incarceration.

Authors:
Laura I Appleman

Duke Law J 2018 Dec;68(3):417-78

Willamette University.

Three widely discussed explanations of the punitive carceral state are racism, harsh drug laws, and prosecutorial overreach. These three narratives, however, only partially explain how our correctional system expanded to its current overcrowded state. Neglected in our discussion of mass incarceration is our largely forgotten history of the long-term, wholesale institutionalization of the disabled. Read More

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December 2018

Adherence to Therapeutic Footwear in Type 2 Diabetes in Malta.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Health Sciences, University of Malta.

Background: The literature reports that people living with diabetes do not adhere to their prescribed therapeutic footwear as instructed. The reason for this is still uncertian although certain footwear characteristics seem to reasons reported leading to reduced level of adherence.

Objectives: To explore the reasons for current adherence or otherwise to prescribed stock footwear amongst patients living with type-2 diabetes. Read More

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December 2018

Association between Freestanding Dialysis Facility Size and Medicare Quality Incentive Program Performance Scores.

Am J Nephrol 2018 Dec 17;49(1):64-73. Epub 2018 Dec 17.

Department of Health Services Policy and Management, Columbia, South Carolina, USA.

Background: Medicare uses a quality incentive program (QIP) criteria to evaluate care in dialysis facilities and apply monetary penalties on underperforming facilities. Smaller dialysis facilities are likely to be rural and operate on lower profit margin; therefore, such facilities are likely to underperform and face Medicare penalties. The variation in QIP scores by facility size is not yet known. Read More

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December 2018

Highly efficient green TADF organic light-emitting diodes by simultaneous manipulating hole and electron transport.

Nanotechnology 2018 Dec 17. Epub 2018 Dec 17.

Key Laboratory of Advanced Display and System Application of Ministry of Education, Shanghai University, Shanghai, P.R.China, Shanghai, CHINA.

This work demonstrates an effective performance improvement by simultaneous manipulating the hole injection and electron transport layers for (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) based green thermally activated delayed fluorescent (TADF) organic light emitting diodes (OLEDs). 3 wt% sorbitol doped PEDOT:PSS layer results in the highest maximum current efficiency (CEmax) of 28.28 cd/A and external quantum efficiency (EQE) of 17. Read More

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December 2018

Safety and efficacy of two starting doses of vandetanib in advanced medullary thyroid cancer.

Endocr Relat Cancer 2019 Feb;26(2):241-250

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study (Nbib1496313) evaluated the benefit-risk of two starting doses of vandetanib in patients with symptomatic or progressive MTC. Patients were randomized 1:1 to receive vandetanib 150 or 300 mg daily and followed for a maximum of 14 months (Part A), with the option to then enter an open-label phase (Part B) investigating vandetanib 100, 150, 200 and 300 mg daily doses. Read More

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February 2019

O pollution in a future climate increases the competition between summer rape and wild mustard.

Plant Physiol Biochem 2018 Dec 11;135:194-205. Epub 2018 Dec 11.

Vytautas Magnus University, Department of Environmental Sciences, Vileikos St. 8-223, LT-44404, Kaunas, Lithuania.

The initial aim of this study was to evaluate an effect of elevated CO concentration and air temperature (future climate) and O pollution on mono- and mixed-culture grown summer rape (Brassica napus L.) and wild mustard (Sinapis arvensis L.). Read More

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December 2018

Sandwich-type electrochemical immunosensor for sensitive detection of CEA based on the enhanced effects of Ag NPs@CS spaced Hemin/rGO.

Biosens Bioelectron 2018 Dec 7;126:785-791. Epub 2018 Dec 7.

School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.

An ultrasensitive sandwich-type electrochemical immunosensor was designed by using gold nanoparticles (Au NPs) as the substrate material and microporous carbon spheres (CS) loading silver nanoparticles (Ag NPs) spaced Hemin/reduced graphene oxide (Hemin/rGO) porous composite materials (Ag NPs@CS-Hemin/rGO) as the detection antibodies (Ab) label for detecting carcinoembryonic antigen (CEA). The Au NPs with good electrical conductivity and biocompatibility could accelerate the electron transfer on the electrode interface and enhance the load capacity of capture antibodies (Ab). Hemin is peroxidase-like substance which has excellent catalytic ability for HO reduction but easy to molecular aggregation and oxidative self-destruction. Read More

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December 2018

Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases.

Biomed Pharmacother 2018 Dec 14;110:857-868. Epub 2018 Dec 14.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Invasive candidiasis (IC) can affect individuals with various underlying diseases hospitalized in different parts of hospitals. In recent decades, IC has caused 27-55% mortality in general population. Although Candida albicans (C. Read More

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December 2018

Interleukin-7 promotes lung-resident CD14 monocytes activity in patients with lung squamous carcinoma.

Int Immunopharmacol 2018 Dec 14;67:202-210. Epub 2018 Dec 14.

Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province 710061, China. Electronic address:

Interleukin (IL)-7 enhances cytokines secretion by CD14 monocytes, and induces recruitment of monocytes to endothelium. As an important regulator to different types of immune cells, the role of IL-7 in modulation of CD14 monocytes is still not fully elucidated. Thus, the aim of current study was to investigate the immunoregulatory activity of IL-7 to peripheral and lung-resident CD14 monocytes in lung squamous carcinoma patients. Read More

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December 2018

In utero exposure to bisphenol A disrupts fetal testis development in rats.

Environ Pollut 2018 Dec 7;246:217-224. Epub 2018 Dec 7.

Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang, 325027, China. Electronic address:

Bisphenol A (BPA) is widely used in consumer products and is a potential endocrine disruptor linked with abnormal development of male reproductive tract. However, its action and its effects on the pathways in the development of male gonad are still unclear. Here we report that effects of BPA exposure during gestation on male gonad development. Read More

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December 2018
4.143 Impact Factor

Extracellular polymeric substances of biofilms: Suffering from an identity crisis.

Water Res 2018 Nov 28;151:1-7. Epub 2018 Nov 28.

Department of Biotechcnology, Delft University of Technology, Delft, the Netherlands. Electronic address:

Microbial biofilms can be both cause and cure to a range of emerging societal problems including antimicrobial tolerance, water sanitation, water scarcity and pollution. The identities of extracellular polymeric substances (EPS) responsible for the establishment and function of biofilms are poorly understood. The lack of information on the chemical and physical identities of EPS limits the potential to rationally engineer biofilm processes, and impedes progress within the water and wastewater sector towards a circular economy and resource recovery. Read More

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November 2018

Behavioral and neural evidence on the processing of ambiguous adjective-noun dependencies in Korean sentence comprehension.

Brain Lang 2018 Dec 14;188:28-41. Epub 2018 Dec 14.

Dept. of Media and Communication, Konkuk Univeirsity, Seoul 5029, Republic of Korea; Brain and Cognition Research Center, Konkuk University, Seoul 5029, Republic of Korea. Electronic address:

In Korean, it is allowed for an adjective to modify a distant noun that appears after an intervening relative clause instead of an adjacent noun. The current study investigated the time course of syntactic and semantic integration between an adjective (A) and an adjacent noun (N1) and/or a distant noun (N2) during on-line reading comprehension of Korean sentences. Semantic congruence between adjectives and nouns were manipulated, such that A was congruent with both N1 and N2, either with N1 or N2, or with none of N1/N2. Read More

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December 2018

Current management of pediatric chiari type 1 malformations.

Clin Neurol Neurosurg 2018 Dec 10;176:122-126. Epub 2018 Dec 10.

Department of Neurosurgery, Albany Medical College, Albany, NY, USA.

Objectives: Pediatric Chiari Type 1 Malformations (CM1) are commonly referred for neurosurgical opinion. The ideal management in children regarding surgical and radiographic decision making is not clearly delineated.

Patients And Methods: We retrospectively reviewed our cohort of patients age 18 years and younger referred to a single neurosurgeon for CM1. Read More

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December 2018

Current perspectives of Australian therapists on rehabilitation and return to sport after anterior cruciate ligament reconstruction: A survey.

Phys Ther Sport 2018 Dec 10;35:139-145. Epub 2018 Dec 10.

Perth Orthopaedic and Sports Medicine Centre, West Perth, Western Australia, Australia.

Objectives: To investigate views and practices of Australian therapists on rehabilitation and return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR).

Design: Survey-based study.

Setting: Online survey platform. Read More

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December 2018

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Houston VA Health Services Research and Development Service Center of Excellence (Houston, TX), Section of Health Services Research, Michael E. DeBakey VA Medical Center (Houston, TX) and Baylor College of Medicine, Houston, TX. Electronic address:

Background & Aims: Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6 months for patients with cirrhosis, via ultrasonography, with or without measurement of serum level of alpha fetoprotein (AFP).

Methods: We previously developed and internally validated an HCC early detection screening (HES) algorithm that included patient's current level of AFP, rate of AFP change, age, level of alanine aminotransferase, and platelet count in a department of Veterans affairs (VA) cohort with active hepatitis C virus-related cirrhosis. Read More

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December 2018

Sublethal concentrations of chlorpyrifos induce changes in the thermal sensitivity and tolerance of anuran tadpoles in the toad Rhinella arenarum?

Chemosphere 2018 Dec 7;219:671-677. Epub 2018 Dec 7.

Departamento de Ecología Evolutiva, Estación Biológica de Doñana, CSIC, Avda. Américo Vespucio s/n, 41092, Sevilla, Spain. Electronic address:

Amphibians are considered one of the groups most susceptible to chemical contamination, therefore are good bio-indicators of aquatic pollution. Synergistic effects of temperature and pesticides have been found in amphibians determining amplified toxicity effect on survival and malformations with increasing temperatures. We studied the sensitivity of sublethal concentrations of chlorpyrifos in Rhinella arenarum tadpoles over on two fitness related thermal traits: locomotor swimming performance and thermal tolerance limits (CT = critical thermal maximum and CT = critical thermal minimum). Read More

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December 2018
1 Read

Identifying sublethal endpoints for evaluating neurotoxic compounds utilizing the fish embryo toxicity test.

Ecotoxicol Environ Saf 2018 Dec 14;170:521-529. Epub 2018 Dec 14.

Department of Biology, Texas Christian University, Fort Worth, TX, USA. Electronic address:

Fish embryos are increasingly being utilized in aquatic toxicity testing, as evidenced by the Organisation for Economic Co-operation and Development's approval of the fish embryo acute toxicity (FET) test. However, the FET test only allows for the estimation of acute toxicity, whereas other test methods such as the larval growth and survival (LGS) test allow for the estimation of both acute and chronic toxicity. Additionally, it has been demonstrated that the FET test is less sensitive than other test methods for some neurotoxic compounds. Read More

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December 2018

Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic.

Ecotoxicol Environ Saf 2018 Dec 14;170:513-520. Epub 2018 Dec 14.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Arsenic poses a profound health risk including male reproductive dysfunction upon prolonged exposure. Histone methylation is an important epigenetic driver; however, its role in arsenic- induced steroidogenic pathogenesis remains obscure. In current study, we investigated the effect of histone H3K9 tri-methylation (H3K9me3) on expression pattern of steroidogenic genes in rat testis after long-term arsenic exposure. Read More

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December 2018

The Intestinal Lymphatic System: Functions and Metabolic Implications.

Cell Mol Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Cardiovascular Research Center and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA; INSERM U970, Paris Cardiovascular Research Center, 75015 Paris, France.

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last two decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. Read More

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December 2018
1 Read

Household air pollution from biomass-burning cookstoves and metabolic syndrome, blood lipid concentrations, and waist circumference in Honduran women: A cross-sectional study.

Environ Res 2018 Dec 10;170:46-55. Epub 2018 Dec 10.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Household air pollution from cooking with solid fuels affects nearly 3 billion people worldwide and is responsible for an estimated 2.5 million premature deaths and 77 million disability-adjusted life years annually. Investigating the effect of household air pollution on indicators of cardiometabolic disease, such as metabolic syndrome, can help clarify the pathways between this widespread exposure and cardiovascular diseases, which are increasing in low- and middle-income countries. Read More

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December 2018

A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes.

Environ Res 2018 Dec 7;170:33-45. Epub 2018 Dec 7.

School of Public Health, Faculty of Medicine, University of Queensland, Herston, Australia; Centre for Air Pollution, Energy and Health Research, Glebe, NSW, Australia.

Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdoor air pollutants and TB incidence, hospital admissions and death (collectively referred to here as 'TB outcomes'). Read More

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December 2018

Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice.

J Control Release 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy. Electronic address:

Extracellular vesicles (EVs), are naturally occurring cargo delivery tools with the potential to be used as drug vehicles of single agents or combination therapies. We previously demonstrated that human lung cancer cell-derived EVs could be used for the systemic delivery of oncolytic virus (OVs) and chemotherapy drugs such as paclitaxel (PTX), leading to enhanced anti-tumor effects in nude mice. In the current work, we evaluated the biodistribution of EVs by using bioluminescence and fluorescence imaging technologies, thus proving the ability of these EVs-formulations to specifically target the neoplasia, while leaving other body tissues unaffected. Read More

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December 2018

Organic Anion Transporting Polypeptide 2B1 - More than a Glass-Full of Drug Interactions.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

University of Washington, School of Pharmacy, Department of Pharmaceutics, Seattle, WA, USA. Electronic address:

The importance of uptake transporters in determining drug disposition is increasingly appreciated. While the focus of regulatory agencies worldwide has been on the hepatic organic anion transporting polypeptides (OATPs) 1B1 and 1B3, there is another isoform of the OATP sub-family, OATP2B1, which should be considered equally relevant. Unlike the other members of the OATP sub-family, OATP2B1 is expressed in multiple organs in humans, including in the intestine and the liver. Read More

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December 2018
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Mechanisms of cardiac ethanol toxicity and novel treatment options.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine II, University Medical Center Regensburg, Germany. Electronic address:

Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood. Read More

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December 2018

Comparing Stress and Arousal Systems in Response to Different Social Contexts in Children with ASD.

Biol Psychol 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN, United States; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.

Response to psychological stress can vary based on the extent to which the context is perceived as stressful, especially under different social conditions. The purpose of this preliminary study was to compare physiological stress (cortisol) and regulation (respiratory sinus arrhythmia, RSA) of 10-12 year old children with autism spectrum disorder (ASD, n = 31) or typical development (TD, n = 25) when exposed to two social stress protocols. The extent to which perceived emotion (affect recognition) and anxiety (state and trait) mediate the stress response was also explored. Read More

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December 2018

Exploiting endogenous opioids: lessons learned from endomorphin 2 in the female rat.

Peptides 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of prescription opioid abuse and attendant deaths. Medicinal harnessing of endogenous opioid antinociception could provide a strategy for continuing to take advantage of the powerful antinociceptive properties of opioids while avoiding their abuse potential. Read More

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December 2018

Body compassion safeguards against the impact of major life events on binge eating.

Appetite 2018 Dec 14. Epub 2018 Dec 14.

CINEICC - Center for Research in Neuropsychology and Cognitive Behavioral Intervention, Portugal. Electronic address:

Body compassion is a fresh construct that incorporates two multidimensional concepts: body image and self-compassion. Although self-compassion has revealed a protective role against body image and eating-related problems (e.g. Read More

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December 2018

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

Antiviral Res 2018 Dec 14. Epub 2018 Dec 14.

Aix-Marseille Université, CNRS UMR 7257, Architecture et Fonction des Macromolécules Biologiques, 163 avenue de Luminy, 13288, Marseille, France. Electronic address:

Arenaviridae is a viral family whose members are associated with rodent-transmitted infections to humans responsible of severe diseases. The current lack of a vaccine and limited therapeutic options make the development of efficacious drugs of high priority. The cap-snatching mechanism of transcription of Arenavirus performed by the endonuclease domain of the L-protein is unique and essential, so we developed a drug design program targeting the endonuclease activity of the prototypic Lymphocytic ChorioMeningitis Virus. Read More

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December 2018

R125H, W240S, C386R, and V507I SLC4A11 mutations associated with corneal endothelial dystrophy affect the transporter function but not trafficking in PS120 cells.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

School of Optometry, Indiana University Bloomington, Bloomington, IN, USA. Electronic address:

SLC4A11 mutations are associated with Fuchs' endothelial corneal dystrophy (FECD), congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome (endothelial dystrophy with auditory deficiency). Mice with genetically ablated Slc4a11 recapitulate CHED, exhibiting significant corneal edema and altered endothelial morphology. We recently demonstrated that SLC4A11 functions as an NH sensitive, electrogenic H transporter. Read More

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December 2018
3 Reads

Mental imagery and colour cues can prevent interference between motor tasks.

Neuropsychologia 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosciences and Movement Sciences, University of Fribourg, Fribourg, Switzerland.

Motor interference can be observed when two motor tasks are learnt in subsequent order. The aim of the current study was to test two approaches potentially mitigating interference effects. The first approach used contextual colour cues requiring only little cognitive attention thus being assumed to be primarily implicit while the second, mental practice/rehearsal that demands much more active cognitive processing being considered explicit. Read More

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December 2018

Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model.

Math Biosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854; Department of Biomedical Engineering, Rutgers The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854. Electronic address:

Pharmacokinetic models are particularly useful to study the underlying and complex physiological mechanisms contributing to clinical differences across patient subgroups or special populations. Unfortunately, the inherent variability of biological systems and knowledge gaps in physiological data limit confidence in model predictions for special populations. Sourcing data to reflect the desired physiologies can be resource intensive, particularly for a larger model. Read More

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December 2018

Considering the relationship between domestic violence and pet abuse and its significance in the veterinary clinical and educational contexts.

N Z Vet J 2018 Dec 17:1-27. Epub 2018 Dec 17.

a Department of Veterinary Clinical Sciences , University of Melbourne School , Werribee , Victoria , Australia 3030.

This thematic review examines the literature regarding the relationship between domestic violence (DV) and pet abuse (PA) particularly in the veterinary clinical and educational contexts. It examines the significance of this relationship for the veterinary profession including the veterinarian's role and associated legal and ethical obligations, and relevant current veterinary education standards, to identify future clinical and educational directions. Articles were sourced from online databases by searching the keywords without date restrictions. Read More

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December 2018

Investigation of the association between the interval from internal teat sealant administration to calving and early-lactation clinical mastitis in New Zealand dairy heifers.

N Z Vet J 2018 Dec 17:1-20. Epub 2018 Dec 17.

b Veterinary Centre Limited , Oamaru, 311 Thames Street, Oamaru 9400 , New Zealand.

Aim: To examine the association between the interval from internal teat sealant (ITS) administration to calving and the incidence of farmer-recorded clinical mastitis in the first 30 days of lactation in pasture-based dairy heifers.

Methods: Heifers that were administered an ITS by a single veterinary business in the South Island of New Zealand over the winter of 2014 were enrolled in a cross-sectional observational study. ITS was administered to all heifers on each participating farm on a single calendar day. Read More

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December 2018

A Flexible Artificial Solid Electrolyte Interphase Formed by DOL Oxidation and Polymerization for Metallic Lithium Anode.

ACS Appl Mater Interfaces 2018 Dec 17. Epub 2018 Dec 17.

Lithium-Tin (Li-Sn) alloy is a perfect substrate material for anode in high-energy density lithium metal secondary batteries. A new approach is proposed to further prevent the Li deposit on Li-Sn alloy substrate from reaction with electrolyte using an artificial solid electrolyte interphase (ASEI) based on electrochemical oxidation and polymerization of DOL precursor with LiTFSI additive. This ASEI layer is flexible, stable, ion conductive, and electrically insulating, which can provide very stable cycling of Li-Sn alloy substrate anode for Li deposition/stripping with average Coulombic efficiency (CE) of 98. Read More

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December 2018

Analysing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Proteomics 2018 Dec 17:e1800176. Epub 2018 Dec 17.

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host-microorganism relationship or they may even serve as useful biomarkers for CRC. Read More

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December 2018

Compartment models for the electrical stimulation of retinal bipolar cells.

PLoS One 2018 17;13(12):e0209123. Epub 2018 Dec 17.

Institute for Analysis and Scientific Computing, Vienna University of Technology, Wiedner Hauptstrasse, Vienna, Austria.

Bipolar cells of the retina are among the smallest neurons of the nervous system. For this reason, compared to other neurons, their delay in signaling is minimal. Additionally, the small bipolar cell surface combined with the low membrane conductance causes very little attenuation in the signal from synaptic input to the terminal. Read More

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December 2018

Do male and female soccer players differ in helping? A study on prosocial behavior among young players.

PLoS One 2018 17;13(12):e0209168. Epub 2018 Dec 17.

Social and Organizational Psychology, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, The Netherlands.

Acting prosocially can be quite challenging in one of the most salient intergroup contexts in contemporary society: Soccer. When winning is the ultimate goal, balancing self-interest with helping a fellow player in distress can be a tough decision; yet it happens. To date, we know little about what motivates soccer players to offer such help in the heat of the game. Read More

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December 2018

Empirically developed dietary inflammatory potential (EDIP) in patients candidate for coronary artery bypass grafting surgery (CABG): Association with metabolic parameters, dietary antioxidant quality score and dietary phytochemical index.

PLoS One 2018 17;13(12):e0208711. Epub 2018 Dec 17.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: It has been suggested that empirically developed dietary inflammatory potential (EDIP) is a diagnostic tool for assessment of inflammatory potential of diet in prediction of risk factors related to chronic disease. In the current work, we examined the association between EDIP with cardio-metabolic risk factors, dietary antioxidant quality score (DAQs), dietary phytochemical index (DPI) and Mediterranean dietary quality index (MEDQI) in patients candidate for CABG.

Materials And Methods: In the current cross-sectional study, the data obtained from Tehran- Heart Center-Coronary Outcome Measurement (THC-COM) study from 454 patients candidate for the CABG were used. Read More

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December 2018
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Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan.

PLoS One 2018 17;13(12):e0206717. Epub 2018 Dec 17.

Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Japan is one of the few rabies-free countries/territories which implement the policy of mandatory vaccination of domestic dogs. In order to assess the economic efficiency of such policy in reducing the economic burden of a future canine rabies outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic decision tree modelling. Input data derived from simulation results of published mathematical model, field investigation conducted by the authors at prefectural governments, literature review, international or Japanese database and empirical data of rabies outbreaks in other countries/territories. Read More

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December 2018

A modular and customizable open-source package for quantum voltage standards operation and control.

PLoS One 2018 17;13(12):e0209246. Epub 2018 Dec 17.

INRiM - Istituto Nazionale di Ricerca Metrologica, Torino, Italy.

This paper presents an open-source package developed in Python that controls and drives a programmable Josephson array to synthesize dc and ac quantum-accurate voltages. Programmable arrays are devices subdivided into independent subsections, each counting a number of series connected Josephson junctions that follows a binary sequence (1, 2, 4, 8, …) to control the output voltage. Our software allows to independently measure the current-voltage characteristics of each subsection by means of a set of arbitrary waveform generators and a nanovoltmeter that measures the voltage across the whole array with high sensitivity. Read More

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December 2018

Insights into life after sport for Spanish Olympians: Gender and career path perspectives.

PLoS One 2018 17;13(12):e0209433. Epub 2018 Dec 17.

Department of Social Sciences Applied to Sport, Physical Activity and Leisure, Sport Sciences Faculty, Universidad Politécnica de Madrid, Madrid, Spain.

The aims of this study were: i) to examine if Dual Career (DC) pathways are independent of gender, ii) to evaluate whether those athletes who followed a DC experienced less difficulty in their integration into the labor force than the athletes devoted entirely to sport regardless of gender, as well as iii) to analyze whether the type of career path chosen was related with the current labor status, and if differences exist between men and women athletes. A quantitative, cross-sectional, and descriptive study was used based on an ad hoc questionnaire. Two-hundred and twenty-eight retired Olympic athletes completed a questionnaire. Read More

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December 2018

Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

PLoS One 2018 17;13(12):e0208516. Epub 2018 Dec 17.

Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as". Read More

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December 2018
1 Read

Robustness of the reproductive number estimates in vector-borne disease systems.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006999. Epub 2018 Dec 17.

Centre for Mathematics and the Environment, University of Exeter, Penryn Campus, Penryn, UK.

Background: The required efforts, feasibility and predicted success of an intervention strategy against an infectious disease are partially determined by its basic reproduction number, R0. In its simplest form R0 can be understood as the product of the infectious period, the number of infectious contacts and the per-contact transmission probability, which in the case of vector-transmitted diseases necessarily extend to the vector stages. As vectors do not usually recover from infection, they remain infectious for life, which places high significance on the vector's life expectancy. Read More

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December 2018

cPLA2α-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling.

PLoS One 2018 17;13(12):e0201322. Epub 2018 Dec 17.

Program in Neuroscience, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Group IVa cytosolic phospholipase A2 (cPLA2α) mediates GPCR-stimulated arachidonic acid (AA) release from phosphatidylinositol 4,5-bisphosphate (PIP2) located in plasma membranes. We previously found in superior cervical ganglion (SCG) neurons that PLA2 activity is required for voltage-independent N-type Ca2+ (N-) current inhibition by M1 muscarinic receptors (M1Rs). These findings are at odds with an alternative model, previously observed for M-current inhibition, where PIP2 dissociation from channels and subsequent metabolism by phospholipase C suffices for current inhibition. Read More

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December 2018

Automatic interpretation of otoliths using deep learning.

PLoS One 2018 17;13(12):e0204713. Epub 2018 Dec 17.

Institute of Marine Research, Bergen, Norway.

The age structure of a fish population has important implications for recruitment processes and population fluctuations, and is a key input to fisheries-assessment models. The current method of determining age structure relies on manually reading age from otoliths, and the process is labor intensive and dependent on specialist expertise. Recent advances in machine learning have provided methods that have been remarkably successful in a variety of settings, with potential to automate analysis that previously required manual curation. Read More

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December 2018

Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat.

PLoS One 2018 17;13(12):e0209291. Epub 2018 Dec 17.

Department of Psychobiology, Faculty of Psychology, Universitat de València, Valencia, Spain.

It is well established that repeated social defeat stress can induce negative long-term consequences such as increased anxiety-like behavior and enhances the reinforcing effect of psychostimulants in rodents. In the current study, we evaluated how the immune system may play a role in these long-term effects of stress. A total of 148 OF1 mice were divided into different experimental groups according to stress condition (exploration or social defeat) and pre-treatment (saline, 5 or 10 mg/kg of the anti-inflammatory indomethacin) before each social defeat or exploration episode. Read More

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December 2018

Effect of High-Dose Statin Pretreatment for Myocardial Perfusion in Patients Receiving Percutaneous Coronary Intervention (PCI): A Meta-Analysis of 15 Randomized Studies.

Med Sci Monit 2018 Dec 17;24:9166-9176. Epub 2018 Dec 17.

Division of Nephrology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND For coronary artery disease, percutaneous coronary intervention (PCI) is the preferred treatment. Reperfusion injury is a common and serious complication of PCI. Studies showed that early statin therapy has a favorable prognostic impact for patients undergoing PCI. Read More

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December 2018
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Williams syndrome: recent advances in our understanding of cognitive, social and psychological functioning.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Purpose Of Review: Since the last review of Williams syndrome in Current Opinion (2001) there have been many advances in knowledge about the cognitive, social and psychological impairments that characterize the disorder. The present review focuses on current research in these areas.

Recent Findings: Williams syndrome is associated with a wide range of cognitive, linguistic, social and other difficulties. Read More

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December 2018

Diagnosis and management of foetal alcohol specturm disorder.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

FASD Specialist Behaviour Clinic, Surrey and Borders Partnership NHS Foundation Trust, Redhill, UK.

Purpose Of Review: Our understanding of the diagnosis and management of Foetal Alcohol Spectrum Disorders (FASD), has been increasingly refined in the last 45 years: This review highlights current understanding and identifies future areas for research.

Recent Findings: Newer techniques such as three-dimensional facial recognition and advanced brain imaging, have advanced our understanding. Despite this, there remain areas, such as the relationship with other neurodevelopmental disorders, that have been insufficiently explored. Read More

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December 2018

Do the Current Findings for Hemodynamic Optimization of the Postcardiac Arrest Patient Take Us Out of Our Arterial Pressure Comfort Zone?

Crit Care Med 2019 Jan;47(1):138-139

Department of Emergency Medicine, University of Colorado, School of Medicine, Aurora, CO Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.

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January 2019
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