1,491 results match your criteria Current Atherosclerosis Reports[Journal]


Recent Updates on the Use of PCSK9 Inhibitors in Patients with Atherosclerotic Cardiovascular Disease.

Curr Atheroscler Rep 2019 Mar 16;21(5):16. Epub 2019 Mar 16.

Division of Cardiology, Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA.

Purpose Of Review: Atherosclerotic cardiovascular disease (ASCVD) is caused by elevated levels of low-density lipoprotein cholesterol (LDL-C). Although statins significantly reduce ASCVD risk, there remains a high degree of residual risk in statin-treated patients. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition has emerged as a significant therapeutic target for further lowering of LDL-C when used in combination with statins. Read More

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http://dx.doi.org/10.1007/s11883-019-0778-6DOI Listing

E-cigarettes and Atherosclerotic Cardiovascular Disease: What Clinicians and Researchers Need to Know.

Curr Atheroscler Rep 2019 Mar 16;21(5):15. Epub 2019 Mar 16.

BREATHE, College of Nursing, University of Kentucky, 2265 Harrodsburg Road, Suite 202, Lexington, KY, 40504, USA.

Purpose Of Review: Electronic cigarettes, commonly known as electronic nicotine delivery systems (ENDS), e-cigarettes, or vapes, are growing in use and popularity. E-cigarettes are not one distinct type of product. These devices have evolved from the initial "cigarette-alike" designs to larger tank-style devices and most recently, smaller "mod-pods" that can be easily hidden. Read More

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http://dx.doi.org/10.1007/s11883-019-0777-7DOI Listing

2018 Cholesterol Guidelines: Key Topics in Primary Prevention.

Curr Atheroscler Rep 2019 Mar 16;21(5):17. Epub 2019 Mar 16.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.

Purpose Of Review: The 2018 American College of Cardiology (ACC) and American Heart Association (AHA) cholesterol guidelines are a comprehensive update providing recommendations for management of patients with high blood cholesterol based on the best available evidence. This review highlights key topics clinicians need to know for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on the 2018 ACC/AHA cholesterol guidelines.

Recent Findings: The guidelines include a broad framework for risk estimation and management for primary prevention of ASCVD. Read More

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http://dx.doi.org/10.1007/s11883-019-0776-8DOI Listing

Can Lp(a) Lowering Against Background Statin Therapy Really Reduce Cardiovascular Risk?

Authors:
Željko Reiner

Curr Atheroscler Rep 2019 Mar 7;21(4):14. Epub 2019 Mar 7.

Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.

Purpose Of Review: The association between elevated plasma levels of lipoprotein (a) [Lp(a)] and atherosclerotic cardiovascular disease (ASCVD) has been discussed for many years. Recent genetic findings have confirmed that elevated Lp(a) similar to elevated LDL-cholesterol (LDL-C) might be causally related to premature ASCVD. Lp(a) is relatively refractory to lifestyle interventions. Read More

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http://dx.doi.org/10.1007/s11883-019-0773-yDOI Listing

Herbal Approach for Management of Atherosclerosis: a Review.

Authors:
Sanjiv Singh

Curr Atheroscler Rep 2019 Feb 28;21(4):12. Epub 2019 Feb 28.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Science and Education, Export Promotions Industrial Park (EPIP), Industrial Area, Dist: Vaishali, Hajipur, Bihar, 844102, India.

Purpose Of Review: Summarize of the reports on antioxidants especially from herbal sources which battle oxidative stress might be proficient to forestall and repair the free radical-prompted vascular damages in overseeing of atherosclerosis.

Recent Findings: Atherosclerosis is the one of the fundamental reason for hypertension, stroke, myocardial localized necrosis, and numerous other cardiovascular illnesses. Atherosclerosis associated path physiological factors like hypercholesterolemia, hypertension, diabetes mellitus, and smoking actuates oxidative stress which are characterized by excessive oxidation and improper exclusion. Read More

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http://dx.doi.org/10.1007/s11883-019-0774-xDOI Listing
February 2019

Strategies to Fill the Gaps in Nutrition Education for Health Professionals through Continuing Medical Education.

Curr Atheroscler Rep 2019 Feb 28;21(4):13. Epub 2019 Feb 28.

Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, NY, 10075, USA.

Purpose Of Review: Recent studies have documented that diet quality in the US is poor and linked to higher rates of cardiovascular disease (CVD), other non-communicable diseases, and total mortality. As a result, nutrition counseling in clinical practice is an evidence-based strategy endorsed by numerous stakeholders. However, medical nutrition education (MNE) in the US has been inadequate, and physician knowledge, competencies, and practices related to diet counseling have been documented to be insufficient. Read More

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http://dx.doi.org/10.1007/s11883-019-0775-9DOI Listing
February 2019
3.417 Impact Factor

Health Factors Associated with Cardiovascular Wellness.

Curr Atheroscler Rep 2019 Feb 12;21(3):10. Epub 2019 Feb 12.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Purpose Of Review: In this review, we discuss a new paradigm for atherosclerotic cardiovascular disease (ASCVD) prevention that is focused on cultivating cardiovascular wellness through the promotion of "health factors."

Recent Findings: Cardiovascular prevention efforts have contributed to falling rates of ASCVD over the past five decades. However, contemporary increases in obesity and diabetes have led to a recent slowing in the annual decline of ASCVD death rates. Read More

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http://dx.doi.org/10.1007/s11883-019-0771-0DOI Listing
February 2019
1 Read
3.417 Impact Factor

Reciprocal Roles of Sleep and Diet in Cardiovascular Health: a Review of Recent Evidence and a Potential Mechanism.

Curr Atheroscler Rep 2019 Feb 12;21(3):11. Epub 2019 Feb 12.

Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Purpose Of Review: This review investigates the potential bi-directional relation between sleep and diet in considering their contribution to cardiovascular health. We further explore the involvement of the gut microbiome in the relationships between poor sleep and dietary intakes and increased cardiovascular disease (CVD) risk.

Recent Findings: There is strong evidence that sleep restriction leads to unhealthy food choices and increased energy intake. Read More

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http://dx.doi.org/10.1007/s11883-019-0772-zDOI Listing
February 2019
2 Reads

Dietary Patterns and Cardiovascular Disease: Insights and Challenges for Considering Food Groups and Nutrient Sources.

Curr Atheroscler Rep 2019 Feb 11;21(3). Epub 2019 Feb 11.

School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, 2522, Australia.

Purpose Of Review: The relationship between dietary patterns and cardiovascular disease has been the subject of much research, but an important methodological consideration is the interdependence between the nutrient composition of foods and the recognition of healthy dietary patterns. This review considers some of the challenges in researching dietary patterns with implications for translation to public health promotions.

Recent Findings: A number of statistical methods have emerged for analysing dietary patterns using population dietary data. Read More

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http://dx.doi.org/10.1007/s11883-019-0770-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373325PMC
February 2019

High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.

Curr Atheroscler Rep 2019 Feb 2;21(2). Epub 2019 Feb 2.

Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

Purpose Of Review: High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appraise the evidence base on the effects of HIIT in comparison to mild- or moderate-intensity interval training (MMIIT) on glycemic control inT2DM. Read More

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http://link.springer.com/10.1007/s11883-019-0767-9
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http://dx.doi.org/10.1007/s11883-019-0767-9DOI Listing
February 2019
9 Reads
3.417 Impact Factor

Rheumatoid Arthritis: Atherosclerosis Imaging and Cardiovascular Risk Assessment Using Machine and Deep Learning-Based Tissue Characterization.

Curr Atheroscler Rep 2019 Jan 25;21(2). Epub 2019 Jan 25.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA.

Purpose Of The Review: Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using traditional risk factor-based calculators either underestimates or overestimates the CV risk. Read More

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http://dx.doi.org/10.1007/s11883-019-0766-xDOI Listing
January 2019
3 Reads

In response to Mobile Stroke Units - Cost-Effective or Just an Expensive Hype?

Curr Atheroscler Rep 2019 Jan 25;21(2). Epub 2019 Jan 25.

Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1007/s11883-019-0764-zDOI Listing
January 2019
2 Reads

Correction to: Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome.

Curr Atheroscler Rep 2019 Jan 25;21(1). Epub 2019 Jan 25.

Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Research 1 Building, Room 3000, Sacramento, CA, 95817, USA.

A portion of this article was previously published as part of an article titled "Human C-reactive protein and the metabolic syndrome" in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9. doi: 10. Read More

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http://dx.doi.org/10.1007/s11883-019-0769-7DOI Listing
January 2019
1 Read

Correction to: Statin Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What is the Value of CRP?

Curr Atheroscler Rep 2019 Jan 21;21(1). Epub 2019 Jan 21.

Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, CA, 95817, USA.

A portion of this article was previously published as part of an article titled "Human C-reactive protein and the metabolic syndrome" in the following journal: Curr Opin Lipidol. 2009 Jun;20(3):182-9. Read More

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http://dx.doi.org/10.1007/s11883-019-0768-8DOI Listing
January 2019
2 Reads

New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease.

Authors:
R Preston Mason

Curr Atheroscler Rep 2019 Jan 12;21(1). Epub 2019 Jan 12.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Purpose Of Review: Treatment of hypercholesterolemia with statins results in significant reductions in cardiovascular risk; however, individuals with well-controlled low-density lipoprotein cholesterol (LDL-C) levels, but persistent high triglycerides (TG), remain at increased risk. Genetic and epidemiologic studies have shown that elevated fasting TG levels are associated with incident cardiovascular events. At effective doses, omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower TG levels but may have additional atheroprotective properties compared to other TG-lowering therapies such as niacin and fibrates. Read More

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http://dx.doi.org/10.1007/s11883-019-0762-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330561PMC
January 2019
3 Reads

Omega-3 Fatty Acid and Cardiovascular Outcomes: Insights From Recent Clinical Trials.

Curr Atheroscler Rep 2019 Jan 10;21(1). Epub 2019 Jan 10.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Purpose Of Review: Omega-3 fatty acids (ω-3 FA) are among the most well-recognized health supplements but their cardiovascular benefits have long been controversial owing to inconsistent results from previous cardiovascular outcomes trials (CVOT). In this article, we provide a short review of existing literature followed by recent randomized clinical trial data, with a discussion of the potential clinical implications of these new findings.

Recent Findings: Data from the randomized, controlled trial REDUCE-IT, when viewed within the context of other recently published trials ASCEND and VITAL, add to a growing body of evidence on the use of ω-3 FA therapies in the treatment of atherosclerotic cardiovascular disease (ASCVD). Read More

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http://link.springer.com/10.1007/s11883-019-0763-0
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http://dx.doi.org/10.1007/s11883-019-0763-0DOI Listing
January 2019
21 Reads

Sex-Based Differences in Chronic Total Occlusion Management.

Curr Atheroscler Rep 2018 Nov 7;20(12):60. Epub 2018 Nov 7.

Division of Cardiology, University of Washington, Seattle, WA, USA.

ᅟ: Chronic total occlusions (CTOs) are an important and increasingly recognized subgroup of coronary lesions, documented in at least 30%, but up to 52% of patients with coronary artery disease (CAD) undergoing coronary angiography. Percutaneous coronary intervention (PCI) of these lesions is increasingly pursued, with excellent success rates. PURPOSE OF REVIEW: It is known that gender differences exist in the presentation of CAD, as well as in clinical outcomes after routine PCI; however, it is not well described how these differences pertain to management of CTOs. Read More

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http://link.springer.com/10.1007/s11883-018-0760-8
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http://dx.doi.org/10.1007/s11883-018-0760-8DOI Listing
November 2018
9 Reads

Reconstituted Discoidal High-Density Lipoproteins: Bioinspired Nanodiscs with Many Unexpected Applications.

Curr Atheroscler Rep 2018 Nov 5;20(12):59. Epub 2018 Nov 5.

Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Purpose Of Review: Summarize the initial discovery of discoidal high-density lipoprotein (HDL) in human plasma and review more recent innovations that span the use of reconstituted nanodisc HDL for membrane protein characterization to its use as a drug carrier and a novel therapeutic agent for cardiovascular disease.

Recent Findings: Using a wide variety of biophysical techniques, the structure and composition of endogenous discoidal HDL have now largely been solved. This has led to the development of new methods for the in vitro reconstitution of nanodisc HDL, which have proven to have a wide variety of biomedical applications. Read More

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http://link.springer.com/10.1007/s11883-018-0759-1
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http://dx.doi.org/10.1007/s11883-018-0759-1DOI Listing
November 2018
13 Reads

Spontaneous Coronary Artery Dissection: an Overview.

Authors:
Sahar Naderi

Curr Atheroscler Rep 2018 Oct 29;20(12):58. Epub 2018 Oct 29.

Division of Cardiology, Kaiser Northern California, 2238 Geary Boulevard, 8th Floor, San Francisco, CA, USA.

Spontaneous coronary artery dissection (SCAD) is a non-inflammatory, non-atherosclerotic cause of acute myocardial infarction (AMI) that, by definition, is not iatrogenic or due to trauma. It is a condition that predominantly affects pre- or perimenopausal women without the traditional risk factors for cardiovascular disease. PURPOSE OF REVIEW: In this review, we will discuss the epidemiology, diagnosis, and management of this condition, with an emphasis on the ongoing research needed to better understand how to care for patients with SCAD. Read More

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http://link.springer.com/10.1007/s11883-018-0761-7
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http://dx.doi.org/10.1007/s11883-018-0761-7DOI Listing
October 2018
13 Reads

Emerging Research on the Implications of Hormone Replacement Therapy on Coronary Heart Disease.

Curr Atheroscler Rep 2018 Oct 22;20(12):57. Epub 2018 Oct 22.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

Purpose Of Review: Cardiovascular disease (CVD) is known to be an increasing cause of mortality among women, particularly postmenopausal women. Hormone replacement therapy (HRT) is a topic that has been investigated over the past decade for its known impact on the cardiovascular system. This review summarizes the evidence and current opinion on the associations between HRT and CVD, evidence both supporting and against HRT use as a prevention to the development of coronary heart disease (CHD). Read More

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http://dx.doi.org/10.1007/s11883-018-0758-2DOI Listing
October 2018
3 Reads

Emergency Department (ED) Triage for Transient Ischemic Attack (TIA).

Curr Atheroscler Rep 2018 Sep 25;20(11):56. Epub 2018 Sep 25.

Stroke Center, Department of Neurology, Hôpital Pierre-Paul Riquet, Toulouse, France.

Purpose Of Review: Patients with transient ischemic attacks (TIAs) have a higher risk for stroke and vascular events. Specialized and organized management, if rapidly initiated in the emergency department (ED), reduces the vascular burden of TIA. This review summarizes the rationale for optimal triage of patients suspected with TIA in the ED, focusing on early diagnosis confirmation, individual risk stratification, and management. Read More

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http://dx.doi.org/10.1007/s11883-018-0755-5DOI Listing
September 2018
2 Reads

T-Wave Indices and Atherosclerosis.

Curr Atheroscler Rep 2018 Sep 17;20(11):55. Epub 2018 Sep 17.

Department of Cardiology, Evangelismos General Hospital of Athens, Athens, Greece.

Tpeak-Tend interval, the time difference between the peak and the end of the T-wave, reflects the degree of dispersion of repolarization. Its prolongation has been associated with higher risks of developing ventricular arrhythmias and sudden cardiac death in different pro-arrhythmic conditions such as Brugada and long QT syndromes. In this review, we will provide a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree. Read More

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http://dx.doi.org/10.1007/s11883-018-0756-4DOI Listing
September 2018
4 Reads
3.420 Impact Factor

How Heart Rate Should Be Controlled in Patients with Atherosclerosis and Heart Failure.

Curr Atheroscler Rep 2018 Sep 17;20(11):54. Epub 2018 Sep 17.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Purpose Of Review: Resting heart rate is an independent risk factor for all-cause and cardiovascular mortality in patients with heart failure. The main objectives are to discuss the prognosis of heart rate, its association with coronary atherosclerosis, and the modalities of control of the heart rate in sinus rhythm and in the rhythm of atrial fibrillation in patients with chronic heart failure.

Recent Findings: As a therapeutic option for control heart rate, medications such as beta-blockers, digoxin, and finally ivabradine have been studied. Read More

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http://dx.doi.org/10.1007/s11883-018-0757-3DOI Listing
September 2018
8 Reads
3.420 Impact Factor

Examining the Role of and Treatment Directed at IL-1β in Atherosclerosis.

Curr Atheroscler Rep 2018 Sep 15;20(11):53. Epub 2018 Sep 15.

Montreal Heart Institute, Montreal, QC, H1T 1C8, Canada.

Purpose: The purpose of this review was to examine the role of IL-1β in the inflammatory process central to the development of atherosclerosis and to discuss current clinical evidence for treatments targeting IL-1β in coronary artery disease.

Recent Findings: IL-1β has been shown to modulate atherosclerotic plaque progression by upregulating the synthesis of adhesion molecules on endothelial cells, as well increasing activation and proliferation of vascular smooth muscle cells. Animal studies have further suggested that alterations in the balance between agonists and antagonists of IL-1β are important in promoting atherosclerosis. Read More

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http://dx.doi.org/10.1007/s11883-018-0754-6DOI Listing
September 2018
2 Reads

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy).

Curr Atheroscler Rep 2018 Sep 14;20(10):52. Epub 2018 Sep 14.

Department of Cardiology, Erasmus MC, Room Na-316, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Purpose Of Review: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome.

Recent Findings: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE). However, studies on the association between circulating biomarkers and NIRS-derived characteristics have not yet been performed. Read More

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http://dx.doi.org/10.1007/s11883-018-0752-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153584PMC
September 2018
7 Reads
3.420 Impact Factor

Gender Differences in Ischemic Cardiomyopathy.

Curr Atheroscler Rep 2018 Sep 3;20(10):50. Epub 2018 Sep 3.

Division of Cardiology, Department of Medicine, Medical University of South Carolina (MUSC), Strom Thurmond Gazes Building, 30 Courtenay Drive, BM 212, MSC 592, Charleston, SC, 29425, USA.

Purpose Of Review: Cardiovascular disease remains the leading cause of death among women globally, majority of which are due to ischemic heart disease. Despite the recent advances in the overall management of CVD, there are unique challenges in the diagnosis and management of women as well as poorer outcomes.

Recent Findings: Women with ischemic cardiomyopathy experience significant morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s11883-018-0750-xDOI Listing
September 2018
14 Reads

Gender Disparities in CAD: Women and Ischemic Heart Disease.

Curr Atheroscler Rep 2018 Sep 4;20(10):51. Epub 2018 Sep 4.

Department of Cardiology, WellSpan Cardiology, 755 Norman Drive, Lebanon, PA, 17042, USA.

Purpose Of Review: The goal of this article is to review the disparities that exist for women who present for treatment of ischemic heart disease.

Recent Findings: It is well known that women are more likely to present with ischemic heart disease at an advanced age with more comorbidities when compared to male counterparts. Despite correction of risk factors, women experience worse outcomes, even in the absence of obstructive coronary artery disease. Read More

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http://dx.doi.org/10.1007/s11883-018-0753-7DOI Listing
September 2018
17 Reads

Mobile Stroke Units - Cost-Effective or Just an Expensive Hype?

Curr Atheroscler Rep 2018 Aug 29;20(10):49. Epub 2018 Aug 29.

Department of Neurology, Saarland University, Kirrbergerstrasse 1, 66421, Homburg, Germany.

Purpose Of Review: Acute stroke is a treatable disease. Nevertheless, only a minority of patients obtain guideline-adjusted therapy. One major reason is the small time window in which therapies have to be administered in order to reverse or mitigate brain injury and prevent disability. Read More

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http://dx.doi.org/10.1007/s11883-018-0751-9DOI Listing
August 2018
22 Reads

Nuts and Cardiovascular Disease Prevention.

Curr Atheroscler Rep 2018 Aug 9;20(10):48. Epub 2018 Aug 9.

School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (IPAN), Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.

Purpose Of Review: We review recent epidemiological and clinical studies investigating the consumption of tree nuts and peanuts and cardiovascular disease (CVD) mortality as well as CVD risk factors.

Recent Findings: A greater consumption of tree nuts and peanuts is associated with a reduced risk of CVD mortality, as well as lower CVD events. Furthermore, risk factors associated with the development of CVD such as dyslipidemia, impaired vascular function, and hypertension are improved with regular tree nut and peanut consumption through a range of mechanism associated with their nutrient-rich profiles. Read More

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http://dx.doi.org/10.1007/s11883-018-0749-3DOI Listing
August 2018
2 Reads

Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead.

Curr Atheroscler Rep 2018 Jul 18;20(9):47. Epub 2018 Jul 18.

Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.

Purpose Of Review: Genome-wide association studies (GWAS) have been the primary tool for unbiased assessment of the genetic basis of coronary artery disease (CAD) for more than a decade. We summarize successes as well as shortcomings of recent studies in this context.

Recent Findings: The number of CAD-associated loci has more than doubled in the past year to 161. Read More

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http://dx.doi.org/10.1007/s11883-018-0748-4DOI Listing
July 2018
2 Reads

Psammomys obesus: a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases.

Curr Atheroscler Rep 2018 Jul 17;20(9):46. Epub 2018 Jul 17.

School of Medicine, Centre for Molecular and Medical Research, Faculty of Health, Deakin University, School of Medicine, Deakin University - 75 Pigdons Rd, Geelong, VIC, 3216, Australia.

Purpose Of Review: This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations. Read More

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http://dx.doi.org/10.1007/s11883-018-0746-6DOI Listing
July 2018
4 Reads

Commentary on: "Implementing a Mediterranean-Style Diet Outside the Mediterranean Region".

Curr Atheroscler Rep 2018 Jul 9;20(9):45. Epub 2018 Jul 9.

School of Sport and Exercise Science, University of Lincoln, Brayford Campus, Lincoln, Lincolnshire, LN6 7TS, UK.

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http://dx.doi.org/10.1007/s11883-018-0744-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061209PMC
July 2018
3 Reads

Advances in Coronary No-Reflow Phenomenon-a Contemporary Review.

Curr Atheroscler Rep 2018 Jul 5;20(9):44. Epub 2018 Jul 5.

Department of Cardiovascular Diseases, Heart & Vascular Institute, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC, 29425, USA.

Purpose Of Review: Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often results in poor clinical outcomes and remains as a relevant consideration in the cardiac catheterization laboratory. Read More

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http://dx.doi.org/10.1007/s11883-018-0747-5DOI Listing
July 2018
4 Reads

Stroke Risk and Vascular Dementia in South Asians.

Curr Atheroscler Rep 2018 Jul 5;20(9):43. Epub 2018 Jul 5.

Department of Neurology, National Institute for Mental Health and Neurosciences, Bangalore, Karnataka, India.

Purpose Of Review: South Asians (SA) are at a higher risk for stroke and vascular dementia due to the disproportionate burden of diabetes, hypertension, and dyslipidemia. This review summarizes the rationale for screening, early detection, and aggressive control of metabolic factors, and critically examines the published literature on primary and secondary stroke prevention.

Recent Findings: South Asians have a higher prevalence of diabetes than non-SA. Read More

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http://dx.doi.org/10.1007/s11883-018-0745-7DOI Listing
July 2018
11 Reads

Correction to: Cardiovascular Disease Prevention: Training Opportunities, the Challenges, and Future Directions.

Curr Atheroscler Rep 2018 Jun 19;20(9):42. Epub 2018 Jun 19.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". Read More

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http://dx.doi.org/10.1007/s11883-018-0743-9DOI Listing
June 2018
10 Reads

Vascular Access-Related Complications in Women: Temporal Trends, Emerging Data, and the Current State of Interventional Cardiology Practice.

Curr Atheroscler Rep 2018 Jun 8;20(8):41. Epub 2018 Jun 8.

Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Drive, Room H2103, Stanford, CA, 94305, USA.

Purpose Of Review: Women undergoing cardiac catheterization, percutaneous coronary intervention, transcatheter aortic valve replacement, and other structural heart interventions have a significantly higher risk of vascular complications and bleeding than men, leading to significant morbidity and mortality. This review highlights the importance of recognizing female sex as a specific and independent risk factor, and focuses on mechanisms of increased risk and strategies to minimize that risk. Smaller caliber peripheral vessels, low body weight, variations in platelet reactivity, and inappropriate dosing of anticoagulant and antiplatelet agents are the currently identified mechanisms for elevated bleeding and vascular complication risk in women. Read More

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http://dx.doi.org/10.1007/s11883-018-0741-yDOI Listing
June 2018
4 Reads

Peripheral Arterial Disease in Women: an Overview of Risk Factor Profile, Clinical Features, and Outcomes.

Curr Atheroscler Rep 2018 Jun 2;20(8):40. Epub 2018 Jun 2.

Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.

Purpose Of Review: Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular disease (CVD), following coronary artery disease (CAD) and stroke. PAD remains underdiagnosed and under-treated in women.

Recent Findings: Women with PAD experience more atypical symptoms and poorer overall health status. Read More

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http://dx.doi.org/10.1007/s11883-018-0742-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984648PMC
June 2018
5 Reads

Cerebral Autoregulation in Stroke.

Curr Atheroscler Rep 2018 May 21;20(8):37. Epub 2018 May 21.

Department of Neurology, Division of Stroke and Neurocritical, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 12-140, Chicago, IL, 60611, USA.

Purpose Of Review: Cerebral autoregulation (CA) is a mechanism that maintains cerebral blood flow constant despite fluctuations in systemic arterial blood pressure. This review will focus on recent studies that measured CA non-invasively in acute cerebrovascular events, a feature unique to the transcranial Doppler ultrasound. We will summarize the rationale for CA assessment in acute cerebrovascular disorders and specifically evaluate the existing data on the value of CA measures in relation to clinical severity, guiding management decisions, and prognostication. Read More

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http://dx.doi.org/10.1007/s11883-018-0739-5DOI Listing
May 2018
6 Reads

Why Weight? An Analytic Review of Obesity Management, Diabetes Prevention, and Cardiovascular Risk Reduction.

Curr Atheroscler Rep 2018 May 21;20(8):39. Epub 2018 May 21.

The E. William Davis, Jr., M.D. Professor of Medical Ethics, Professor of Medicine Chief, Division of Medical Ethics, Weill Cornell Medical College, New York, NY, USA.

Purpose Of Review: In this review, we examine one of the ironies of American health care-that we pay more for disease management than disease prevention. Instead of preventing type 2 diabetes (T2DM) by treating its precursor, obesity, we fail to provide sufficient insurance coverage for weight management only to fund the more costly burden of overt T2DM.

Recent Findings: There is a vital need for expanded insurance coverage to help foster a weight-centric approach to T2DM management. Read More

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http://dx.doi.org/10.1007/s11883-018-0740-zDOI Listing
May 2018
20 Reads

Mindset and Communication Barriers in the Diffusion of Bariatric Surgery.

Curr Atheroscler Rep 2018 May 21;20(8):38. Epub 2018 May 21.

Department of Surgery and Transplantation, University Hospital Zürich, Zürich, Switzerland.

Purpose Of Review: Cumulating evidence is available to demonstrate the efficacy of bariatric surgery (BS) in achieving weight loss and optimizing comorbidities. However, currently, only a minority of eligible patients approaches bariatric centers. The underuse of BS can no longer be explained by the lack of evidence supporting its beneficial outcomes along with its favorable safety-profile, rather, by the supporting infrastructure, insurance coverage, and mindset of society, including potential patients and allied healthcare professionals. Read More

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http://link.springer.com/10.1007/s11883-018-0738-6
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http://dx.doi.org/10.1007/s11883-018-0738-6DOI Listing
May 2018
6 Reads

Anticoagulation Resumption After Intracerebral Hemorrhage.

Curr Atheroscler Rep 2018 May 21;20(7):32. Epub 2018 May 21.

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, England, UK.

Purpose Of Review: Decision-making on resuming oral anticoagulant (OAC) after intracerebral hemorrhage (ICH) evokes significant debate among clinicians. Such patients have been excluded from randomized clinical trials. This review article provides a comprehensive summary of the evidence on anticoagulation resumption after ICH. Read More

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http://dx.doi.org/10.1007/s11883-018-0733-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960649PMC
May 2018
6 Reads

Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End?

Curr Atheroscler Rep 2018 May 21;20(7):36. Epub 2018 May 21.

Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Purpose Of Review: The purpose of this review is to focus on the outcome of recent antioxidant interventions using synthetic and naturally occurring molecules established as adjuvant strategies to lipid-lowering or anti-inflammatory therapies designed to reduce the risk of cardiovascular disease.

Recent Findings: To date, accumulated evidence regarding oxidation as a pro-atherogenic factor indicates that redox biochemical events involved in atherogenesis are indeed a very attractive target for the management of cardiovascular disease in the clinic. Nevertheless, although evidence indicates that redox reactions are important in the initiation and progression of atherosclerosis, oxidation with a pro-atherogenic context does not eliminate the fact that oxidation participates in many cases as an essential messenger of important cellular signaling pathways. Read More

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http://dx.doi.org/10.1007/s11883-018-0737-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960648PMC
May 2018
5 Reads

Cardiovascular Disease Prevention: Training Opportunities, the Challenges, and Future Directions.

Curr Atheroscler Rep 2018 May 21;20(7):35. Epub 2018 May 21.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Purpose: Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide, necessitating major efforts in prevention. This review summarizes the currently available training opportunities in CVD prevention for fellows-in-training (FITs) and residents. We also highlight the challenges and future directions for CVD prevention as a field and propose a structure for an inclusive CVD prevention training program. Read More

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http://dx.doi.org/10.1007/s11883-018-0735-9DOI Listing
May 2018
5 Reads

Prehospital Prediction of Large Vessel Occlusion in Suspected Stroke Patients.

Curr Atheroscler Rep 2018 May 21;20(7):34. Epub 2018 May 21.

Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.

Purpose Of Review: Recent advances in endovascular thrombectomy have made acute ischemic stroke due to a large vessel occlusion more treatable than ever. Rapid access to treatment remains paramount and multiple large vessel occlusion prediction scales have been created to enhance prehospital identification and triage of these patients. This review summarizes the current state of large vessel occlusion prediction scales, proposes a set of ideal scale features, and discusses the future of these scales and prehospital neurological emergency response systems. Read More

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http://dx.doi.org/10.1007/s11883-018-0734-xDOI Listing
May 2018
4 Reads

A Survey on Coronary Atherosclerotic Plaque Tissue Characterization in Intravascular Optical Coherence Tomography.

Curr Atheroscler Rep 2018 May 21;20(7):33. Epub 2018 May 21.

Coronary Arterial Division, AtheroPoint™, Roseville, CA, USA.

Purpose Of Review: Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk. The characterization and quantification of coronary plaque components are not only vital but also a challenging task which can be possible using high-resolution imaging techniques. Read More

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http://dx.doi.org/10.1007/s11883-018-0736-8DOI Listing
May 2018
6 Reads

The Present and the Future of Genetic Testing in Familial Hypercholesterolemia: Opportunities and Caveats.

Curr Atheroscler Rep 2018 May 19;20(6):31. Epub 2018 May 19.

School of Medicine, Royal Perth Hospital, University of Western Australia, GPO Box X2213, Perth, WA, 6847, Australia.

Purpose Of Review: We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research.

Recent Findings: The uptake of massively parallel sequencing in research and diagnostic laboratories has enabled expanded testing for FH and its phenocopies, with the added advantage that copy number variants can be detected. However, increasing the number of genes tested increases the number of variants detected, which may or may not be pathogenic. Read More

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http://dx.doi.org/10.1007/s11883-018-0731-0DOI Listing
May 2018
7 Reads
3.420 Impact Factor

Triad of the Ischemic Cardiovascular Disease in People Living with HIV? Association Between Risk Factors, HIV Infection, and Use of Antiretroviral Therapy.

Curr Atheroscler Rep 2018 May 18;20(6):30. Epub 2018 May 18.

Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Purpose Of Review: This review is focused on cardiovascular risk factors in HIV-infected people.

Recent Findings: Antiretroviral therapy (ART) has significantly increased the life expectancy of HIV-infected people. Thus, this population has experienced non-HIV-related diseases, mainly cardiovascular diseases. Read More

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http://dx.doi.org/10.1007/s11883-018-0727-9DOI Listing
May 2018
3 Reads
3.420 Impact Factor

Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review.

Curr Atheroscler Rep 2018 May 16;20(6):29. Epub 2018 May 16.

Department of Pharmacotherapy & Outcomes Science, VCU School of Pharmacy, 1112 E. Clay St., Box 980533, Richmond, VA, 23298-0533, USA.

Purpose Of Review: This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease.

Recent Findings: CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. Read More

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http://link.springer.com/10.1007/s11883-018-0730-1
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http://dx.doi.org/10.1007/s11883-018-0730-1DOI Listing
May 2018
17 Reads

Implementing a Mediterranean-Style Diet Outside the Mediterranean Region.

Curr Atheroscler Rep 2018 May 4;20(6):28. Epub 2018 May 4.

School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, SA, 5000, Australia.

Purpose Of Review: Populations surrounding the Mediterranean basin have traditionally reaped health benefits from a Mediterranean diet (MedDiet), which may benefit Westernized countries plagued by chronic disease. But is it feasible to implement beyond the Mediterranean? To answer this question, we present evidence from randomized controlled trials that achieved high dietary compliance rates with subsequent physical and mental health benefits.

Recent Findings: In the 1960s, the Seven Countries Study identified dietary qualities of Mediterranean populations associated with healthy aging and longevity. Read More

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http://dx.doi.org/10.1007/s11883-018-0732-zDOI Listing
May 2018
9 Reads
1 Citation
3.420 Impact Factor