1,457 results match your criteria Current Alzheimer Research [Journal]


Is Brain-Derived Neurotrophic Factor a common link between neurodegenerative disorders and cancer?

Curr Alzheimer Res 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh. India.

Background: Cancer is a common disease caused by excessive proliferation of cells and neurodegenerative diseases are the disorders caused because of degeneration of neurons. Both can be considered as diseases caused by dysregulation of cell cycle events. Recent data suggests that there is a strong inverse association between cancer and neurodegenerative disorders, there is indirect evidence to postulate Brain-derived neurotrophic factor (BDNF) as apotential molecular link in this association. Read More

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http://dx.doi.org/10.2174/1567205016666190408123947DOI Listing
April 2019
1 Read
3.889 Impact Factor

Elevated plasma level of D-dimer predicts the high risk of early cognitive impairment in type 2 diabetic patients as carotid artery plaques become vulnerable or aggrave.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing. China.

Background And Objective: D-dimer prompts fibrinolysis system, which is involved in Alzheimer's disease and the complications of type 2 diabetic patients, especially among those with carotid artery plaques. Hence, this study aims to investigate the role of D-dimer in early cognitive impairment among type 2 diabetic patients with carotid artery plaques.

Method: A total of 175 Chinese patients with type 2 diabetes were recruited and divided into two groups according to the Montreal Cognitive Assessment score. Read More

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http://dx.doi.org/10.2174/1567205016666190321164741DOI Listing
March 2019
1 Read

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer's disease?

Curr Alzheimer Res 2019 Mar 24. Epub 2019 Mar 24.

IPMC, UMR7275 CNRS/UNS, Laboratory of Excellence DistALZ, 660 route des Lucioles, 0660 Valbonne. France.

Background: Alzheimer's disease (AD) is associated with extracellular accumulation and aggregation of amyloid β (Aβ) peptides ultimately seeding in senile plaques. Recent data show that their direct precursor C99 (βCTF) also accumulates in AD-affected brain as well as in AD-like mouse models. C99 is consistently detected much earlier than Aβ, suggesting that this metabolite could be an early contributor to AD pathology. Read More

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http://dx.doi.org/10.2174/1567205016666190325092841DOI Listing
March 2019
6 Reads

Retinoic acid and the gut microbiota in Alzheimer's disease: fighting back-to-back?

Authors:
Kristina Endres

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg-University, Mainz. Germany.

Background: There is growing evidence that the gut microbiota may play an important role in neurodegenerative diseases such as Alzheimer's disease. However, how these commensals influence disease risk and progression still has to be deciphered.

Objective: The objective of this review was to summarize current knowledge on the interplay between gut microbiota and retinoic acid. Read More

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http://dx.doi.org/10.2174/1567205016666190321163705DOI Listing
March 2019
1 Read

Therapeutic strategies targeting amyloid-β in Alzheimer's disease.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

iMed.ULisboa - Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto 1649-003 Lisboa. Portugal.

Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and aggregation. AD is pathologically characterized by senile plaques formed by extracellular amyloid-β (Aβ) peptide and intracellular neurofibrillary tangles (NFT) formed by hyperphosphorylated tau protein. Extensive synaptic loss and neuronal degeneration are responsible for memory impairment, cognitive decline and behavioral dysfunctions typical of AD. Read More

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http://dx.doi.org/10.2174/1567205016666190321163438DOI Listing
March 2019
1 Read

Strategies for the Recruitment and Retention of Racial/Ethnic Minorities in Alzheimer Disease and Dementia Clinical Research.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Brown School, Washington University in St. Louis, Saint Louis, MO. United States.

Background: Racial/ethnic minorities have among the highest risks for Alzheimer disease and dementia, but remain underrepresented in clinical research studies.

Objective: To synthesize the current evidence on strategies to recruit and retain racial/ethnic minorities in Alzheimer disease and dementia clinical research.

Method: We conducted a systematic review by searching CINAHL, EMBASE, MEDLINE, PsycINFO, and Scopus. Read More

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http://dx.doi.org/10.2174/1567205016666190321161901DOI Listing
March 2019
7 Reads

In silico evaluation of acetylation mimics in the 27 lysine residues of human tau protein.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Korea Zoonosis Research Institute, Chonbuk National University, Iksan, Jeonbuk 570-390. Korea.

Background: Various neurodegenerative diseases, including Alzheimer's disease (AD), are related to abnormal hyper-phosphorylated microtubule-associated protein tau accumulation in brain lesions. Recent studies have focused on toxicity caused by another post-translational modification (PTM), acetylation of the lysine (K) residues of tau protein. Because there are numerous acetylation sites, several studies have introduced mimics of tau acetylation using amino acid substitutions from lysine to glutamine (Q). Read More

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http://dx.doi.org/10.2174/1567205016666190321161032DOI Listing
March 2019
4 Reads

Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer's Disease.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Division of Neurotoxicology National Center for Toxicological Research, CDER/FDA, White Oak, MD-20993. United States.

Background: Alzheimer's disease (AD) is the most common type of dementia characterized by amyloid plaques containing amyloid beta (Aβ) peptides and neurofibrillary tangles containing tau protein. In addition to neuronal loss, cerebral amyloid angiopathy (CAA) commonly occurs in AD. CAA is characterized by Aβ deposition in brain microvessels. Read More

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http://dx.doi.org/10.2174/1567205016666190321155422DOI Listing
March 2019
14 Reads
3.889 Impact Factor

Systemic and CNS inflammation crosstalk: implications for Alzheimer's Disease.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens. Greece.

After years of failed therapeutic attempts targeting beta-amyloid (Aβ) in AD, there is now increasing evidence suggesting that inflammation holds a pivotal role in AD pathogenesis and immune pathways can possibly comprise primary therapeutic targets. Inflammation is a key characteristic of numerous diseases including neurodegenerative disorders and thus not surprisingly suppression of inflammation frequently constitutes a major therapeutic strategy for a wide spectrum of disorders. Several brain-resident and peripherally-derived immune populations and inflammatory mediators are involved in AD pathophysiology, with microglia comprising central cellular player in the disease process. Read More

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http://dx.doi.org/10.2174/1567205016666190321154618DOI Listing
March 2019
9 Reads

Physical Activity as a Moderator of Alzheimer Pathology: a Systematic Review of Observational Studies.

Curr Alzheimer Res 2019 Mar 14. Epub 2019 Mar 14.

Danish Dementia Research Centre, Section 6911, Department of Neurology, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen. Denmark.

Introduction: Observational studies have found that physical activity is associated with a reduced risk of cognitive decline and dementia. Whether physical activity may also reduce the level of AD pathology, remains undetermined.

Objective: To examine the relationship between physical activity and AD biomarkers (beta-amyloid1-42, total tau and phosphorylated tau in CSF, amyloid PET, hippocampal atrophy on MRI and parieto-temporal hypometabolism on brain 18F-FDG-PET). Read More

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http://dx.doi.org/10.2174/1567205016666190315095151DOI Listing
March 2019
3 Reads

Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex.

Curr Alzheimer Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Psychology, University of Alberta, Edmonton. Canada.

Background: Apolipoprotein E (APOE) is a prominent genetic risk factor for Alzheimer's disease (AD) and a frequent target for associations with non-demented and cognitively impaired aging. APOE offers a unique opportunity to evaluate two dichotomous comparisons and selected gradations of APOE risk. Some evidence suggests that APOE effects may differ by sex and emerge especially in interaction with other AD-related biomarkers (e. Read More

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http://dx.doi.org/10.2174/1567205016666190315094452DOI Listing
March 2019
9 Reads

Mitigating Alzheimer's Disease by Natural Polyphenols : A Review.

Curr Alzheimer Res 2019 Mar 14. Epub 2019 Mar 14.

Département de physique, Université de Montréal, C.P. 6228, succ. Centre-ville, Montreal (QC). Canada.

According to Alzheimer's Disease International (ADI), nearly 50 million people worldwide live with dementia in 2017, and this number is expected to triple by 2050. Despite years of research in this field, the root cause and mechanisms responsible for Alzheimer's disease (AD) have not yet been fully elucidated. Moreover, promising preclinical results have repeatedly failed to translate into treatments for people. Read More

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http://dx.doi.org/10.2174/1567205016666190315093520DOI Listing
March 2019
3 Reads

N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy.

Curr Alzheimer Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove. Czech Republic.

Fifteen differently substituted N-alkylated tacrine derivatives were synthesized as potential candidates for Alzheimer's disease treatment. Several newly prepared compounds displayed better acetylcholinesterase inhibitory activities in relation to tacrine. Docking studies revealed an importance of an alkyl chain contributing to better fitting of the inhibitor into the enzyme. Read More

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http://dx.doi.org/10.2174/1567205016666190314163942DOI Listing
March 2019
2 Reads

Lead (Pb) in Alzheimer's Dementia: A Systematic Review of Human Case-control Studies.

Curr Alzheimer Res 2019 Mar 10. Epub 2019 Mar 10.

Department of Psychiatry, University of Toronto, Toronto. Canada.

Background: Alzheimer's dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD.

Objective: We aimed to review the literature to clarify the potential role of Pb in AD and to guide future research. Read More

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http://dx.doi.org/10.2174/1567205016666190311101445DOI Listing

Abnormal Saccadic Intrusions with Alzheimer's Disease in Darkness.

Curr Alzheimer Res 2019 Mar 10. Epub 2019 Mar 10.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki. Japan.

Background: Classified as saccadic intrusions, square-wave jerks (SWJs) have been observed during visual fixation (VF) in Alzheimer's disease (AD). However, the pathological significance of this phenomenon remains unclear.

Objective: The present study analyzed the characteristics of SWJs in patients with AD with their eyes open in the dark without VF. Read More

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http://dx.doi.org/10.2174/1567205016666190311102130DOI Listing

Pharmacological Interventions to Attenuate Alzheimer's Disease Progression: The Story So Far.

Curr Alzheimer Res 2019 ;16(3):261-277

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the elderly. Up to date, the available pharmacological options for AD are limited to cholinesterase inhibitors and memantine that may only provide modest symptomatic management with no significance in slowing down the disease progression. Over the past three decades, the increased interest in and the understanding of AD major pathological hallmarks have provided an insight into the mechanisms mediating its pathogenesis, which in turn introduced a number of hypotheses and novel targets for the treatment of AD. Read More

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http://dx.doi.org/10.2174/1567205016666190301111120DOI Listing
January 2019
1 Read

Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice.

Curr Alzheimer Res 2019 ;16(3):219-232

Department of Histology & Embryology, School of Basic Medical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Background: Amyloid-β (Aβ) accumulation plays a critical role in the pathogenesis of Alzheimer's disease (AD) lesions. Deficiency of Serotonin signaling recently has been linked to the increased Aβ level in transgenic mice and humans. In addition, tryptophan hydroxylase-2 (Tph2), a second tryptophan hydroxylase isoform, controls brain serotonin synthesis. Read More

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http://dx.doi.org/10.2174/1567205016666190301110110DOI Listing
January 2019
5 Reads

Naturalistic Measurement of Sleep in Older Adults with Amnestic Mild Cognitive Impairment: Anxiety Symptoms Do Not Explain Sleep Disturbance.

Curr Alzheimer Res 2019 ;16(3):233-242

Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Background: Sleep disturbance is prevalent in Alzheimer's disease (AD). In amnestic mild cognitive impairment (aMCI), the preclinical stage of AD, deterioration in sleep quality has also been reported. Consensus is lacking, however, regarding what aspects of sleep are characteristically affected, whether the setting of the sleep recordings impacts these findings, and whether anxiety may account for the differences. Read More

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http://dx.doi.org/10.2174/1567205016666190301104645DOI Listing
January 2019
1 Read

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology in vivo.

Curr Alzheimer Res 2019 Feb 28. Epub 2019 Feb 28.

Department of Neurobiology, Sagol School of Neurosciences, The George S. Wise Faculty of Life Sciences, Tel Aviv University. Israel.

Background: Alzheimer's disease (AD) is associated with impairments in key brain Mitogen-Activated Protein Kinase (MAPK) signaling cascades including the p38, c-Jun N-terminal kinase (JNK), ERK and Akt pathways. Apolipoprotein E4 (ApoE4) is the most prevalent genetic risk factor of AD.

Objectives: To investigate the extent to which the MAPK signaling pathway plays a role in mediating the pathological effects of apoE4 and can be reversed by experimental manipulations. Read More

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http://dx.doi.org/10.2174/1567205016666190228120254DOI Listing
February 2019

Synthesis of New Galanthamine-Peptide Derivatives Designed for Prevention and Treatment of Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(3):183-192

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, Sofia 1000, Bulgaria.

Background: Although no effective treatment for the Alzheimer's disease currently exist, some drugs acting as Acetylcholinesterase inhibitors, like galanthamine have positively affected such patients. β- and/or γ-secretase inhibitors are another type of potential drugs. Here we report synthesis of new peptide-galanthamine derivatives, with expected inhibitory activity against both Acetylcholinesterase and β-secretase. Read More

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http://dx.doi.org/10.2174/1567205016666190228123923DOI Listing
January 2019

Piper sarmentosum Roxb. Root Extracts Confer Neuroprotection by Attenuating Beta Amyloid-Induced Pro-Inflammatory Cytokines Released from Microglial Cells.

Curr Alzheimer Res 2019 ;16(3):251-260

School of Pharmacy, International Medical University, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarmentosum Roxb. Read More

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http://dx.doi.org/10.2174/1567205016666190228124630DOI Listing
January 2019

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(3):209-218

Department of Clinical Chemistry and Biochemistry, Military-Medical Faculty, Medical University of Lodz, Lodz, Poland.

Objectives: There is a body of evidence that neurodegenerative disease entities are directly correlated with the perturbations on the molecular level. Hence, the ER stress-mediated Unfolded Protein Response (UPR) is activated resulting in PERK-dependent phosphorylation of the Eukaryotic initiation factor 2 (eIF2α). Thus, the levels of ATF4 and CHOP proteins are significantly increased, which subsequently switches the pro-adaptive branch of the UPR into the pro-apoptotic directly leading to neuronal loss and initiation of the neurodegenerative process. Read More

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http://dx.doi.org/10.2174/1567205016666190228121157DOI Listing
January 2019
7 Reads

Donepezil Derivatives Targeting Amyloid-β cascade in Alzheimer's Disease.

Curr Alzheimer Res 2019 Feb 28. Epub 2019 Feb 28.

National Institute of Mental Health, Topolova 748, 250 67 Klecany. Czech Republic.

Alzheimer's disease (AD) is a neurodegenerative disorder with an increasing impact on society. Because currently available therapy has only a short-term effect, a huge number of novel compounds are developed every year exploiting knowledge of the various aspects of AD pathophysiology. To better address the pathological complexity of AD, one of the most extensively pursued strategies by medicinal chemists is based on multi-target-directed ligands (MTDLs). Read More

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http://dx.doi.org/10.2174/1567205016666190228122956DOI Listing
February 2019

Distinctive effects of aerobic and resistance exercise modes on neurocognitive and biochemical changes in individuals with mild cognitive impairment.

Curr Alzheimer Res 2019 Feb 28. Epub 2019 Feb 28.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences. Slovakia.

Background: Decreased levels of the neuroprotective growth factors, low-grade inflammation, and reduced neurocognitive functions during aging are associated with neurodegenerative diseases, such as Alzheimer's disease. Physical exercise modifies these disadvantageous phenomena while a sedentary lifestyle promotes them.

Purpose: The purposes of the present study included investigating whether both aerobic and resistance exercise produce divergent effects on the neuroprotective growth factors, inflammatory cytokines, and neurocognitive performance, and further exploring whether changes in the levels of these molecular biomarkers are associated with alterations in neurocognitive performance. Read More

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http://dx.doi.org/10.2174/1567205016666190228125429DOI Listing
February 2019
17 Reads

Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.

Curr Alzheimer Res 2019 Feb 28. Epub 2019 Feb 28.

Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4. Czech Republic.

A novel molecule 2 formed by combining 6-chlorotacrine (6-Cl-THA) and memantine proved to be a promising multipotent hybrid capable of blocking the action of acetylcholinesterase (AChE) as well as N-methyl-D-aspartate receptors (NMDARs). The presented hybrid surpassed the AChE inhibitory activity of the parent compound 6 Cl THA twofold. Our recently reported results have pointed out that apart from its anticholinesterase activity tacrine is able to block NMDARs. Read More

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http://dx.doi.org/10.2174/1567205016666190228122218DOI Listing
February 2019
1 Read

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

Curr Alzheimer Res 2019 ;16(2):91-101

Department of Neurology, Danish Dementia Research Centre, University of Copenhagen, Rigshospitalet, Denmark.

Background: Determining the underlying etiology of dementia can be challenging. Computer- based Clinical Decision Support Systems (CDSS) have the potential to provide an objective comparison of data and assist clinicians.

Objectives: To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnosis of dementia in memory clinics. Read More

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http://www.eurekaselect.com/168748/article
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http://dx.doi.org/10.2174/1567205016666190103152425DOI Listing
January 2019
7 Reads
3.889 Impact Factor

Identify Compounds' Target Against Alzheimer's Disease Based on In-Silico Approach.

Curr Alzheimer Res 2019 ;16(3):193-208

School of Life Sciences, Shanghai University, Shanghai 200444, China.

Background: Alzheimer's disease swept every corner of the globe and the number of patients worldwide has been rising. At present, there are as many as 30 million people with Alzheimer's disease in the world, and it is expected to exceed 80 million people by 2050. Consequently, the study of Alzheimer's drugs has become one of the most popular medical topics. Read More

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http://dx.doi.org/10.2174/1567205016666190103154855DOI Listing
January 2019
11 Reads

Abnormal Sleep Behaviours Across the Spectrum of Alzheimer's Disease Severity: Influence of APOE Genotypes and Lewy Bodies.

Curr Alzheimer Res 2019 ;16(3):243-250

Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada.

Background: The Apolipoprotein (APOE) ε4 allele is a well-known risk factor for Alzheimer's Disease (AD), and sleep disturbances are commonly associated with AD. However, few studies have investigated the relationship between APOE ε4 and abnormal sleep patterns (N+) in AD.

Objective: To examine the relationship between APOE genotype, Lewy body pathology, and abnormal sleep patterns in a large group of subjects with known AD load evaluated upon autopsy. Read More

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http://dx.doi.org/10.2174/1567205016666190103161034DOI Listing
January 2019
3 Reads

Organotypic Brain Slices of ADULT Transgenic Mice: A Tool to Study Alzheimer's Disease.

Authors:
Christian Humpel

Curr Alzheimer Res 2019 ;16(2):172-181

Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Innsbruck, Austria.

Transgenic mice have been extensively used to study the Alzheimer pathology. In order to reduce, refine and replace (3Rs) the number of animals, ex vivo cultures are used and optimized. Organotypic brain slices are the most potent ex vivo slice culture models, keeping the 3-dimensional structure of the brain and being closest to the in vivo situation. Read More

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http://dx.doi.org/10.2174/1567205016666181212153138DOI Listing
January 2019
7 Reads

The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia.

Curr Alzheimer Res 2019 ;16(2):109-115

Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, United States.

Background: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown.

Objective: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. Read More

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http://dx.doi.org/10.2174/1567205016666181212162424DOI Listing
January 2019
6 Reads
3.889 Impact Factor

Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial.

Curr Alzheimer Res 2019 ;16(2):146-155

Faculty of Medicine Ringgold Standard Institution, Thammasat University, Klonglaung, Pathum Thani, Thailand.

Background: Dementia is a common medical disorder in the elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. Read More

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http://dx.doi.org/10.2174/1567205016666181212153720DOI Listing
January 2019
1 Read

Down-Regulation of Mir-107 Worsen Spatial Memory by Suppressing SYK Expression and Inactivating NF-ΚB Signaling Pathway.

Curr Alzheimer Res 2019 ;16(2):135-145

Qingdao Mental Health Center, Qingdao 266034, Shandong, China.

Background: Alzheimer's Disease (AD) is a chronic progressive neurodegenerative disorder in a central nervous system seen.

Objective: We aimed to study the miR-107 in Alzheimer's Disease (AD) pathology through regulating SYK and NF-κB signaling pathway.

Method: Bioinformatics analysis was performed to screen NF-κB signaling pathway and differentially expressed genes. Read More

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http://dx.doi.org/10.2174/1567205016666181212154347DOI Listing
January 2019
1 Read

Computational and In-Vitro Validation of Natural Molecules as Potential Acetylcholinesterase Inhibitors and Neuroprotective Agents.

Curr Alzheimer Res 2019 ;16(2):116-127

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, 173234, India.

Background: Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is used to identify new and safer 'disease-modifying drugs'.

Methods: Herein, we screened 646 small molecules of natural origin having reported pharmacological and functional values through in-silico docking studies to predict safer neuromodulatory molecules with potential to modulate acetylcholine metabolism. Read More

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http://dx.doi.org/10.2174/1567205016666181212155147DOI Listing
January 2019
3 Reads

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF.

Curr Alzheimer Res 2019 ;16(2):102-108

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Australia.

Background: Images of amyloid-β pathology characteristic of Alzheimer's disease are difficult to consistently and accurately segment, due to diffuse deposit boundaries and imaging variations.

Methods: We evaluated the performance of ImageSURF, our open-source ImageJ plugin, which considers a range of image derivatives to train image classifiers. We compared ImageSURF to standard image thresholding to assess its reproducibility, accuracy and generalizability when used on fluorescence images of amyloid pathology. Read More

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http://dx.doi.org/10.2174/1567205016666181212152622DOI Listing
January 2019
1 Read
3.889 Impact Factor

A Novel Cell-based β-secretase Enzymatic Assay for Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(2):128-134

Department of Psychiatry, Townsend Family Laboratories, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

Background: Deposition of the amyloid β protein (Aβ) into neuritic plaques is the neuropathological hallmark of Alzheimer's Disease (AD). Aβ is generated through the cleavage of the Amyloid Precursor Protein (APP) by β-secretase and γ-secretase. Currently, the evaluation of APP cleavage by β-secretase in experimental settings has largely depended on models that do not replicate the physiological conditions of this process. Read More

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http://dx.doi.org/10.2174/1567205016666181212151540DOI Listing
January 2019
10 Reads

One-year Outcome of Shanghai Mild Cognitive Impairment Cohort Study.

Curr Alzheimer Res 2019 ;16(2):156-165

Institute of Neurology, Huashan Hospital Fudan University, Shanghai, China.

Background & Objective: The purpose of this study is to identify the risk factors associated with the conversion from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) dementia for the early detection of AD.

Methods: The study comprised a prospective cohort study that included 400 MCI subjects with annual follow-ups for 3 years.

Results: During the first 12 months' follow-up, 42 subjects converted to Alzheimer's dementia (21 probable AD and 21 possible AD), two subjects converted to other types of dementia and 56 subjects lost follow. Read More

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http://www.eurekaselect.com/167828/article
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http://dx.doi.org/10.2174/1567205016666181128151144DOI Listing
January 2019
23 Reads

Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood.

Curr Alzheimer Res 2019 ;16(1):29-38

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakon Pathom, Thailand.

Background: Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the Amyloid Precursor Protein (APP)-cleaving enzymes directly affect the formation of Amyloid Beta (Aβ) plaques, a neuropathological hallmark of AD.

Objective: We used peripheral blood from AD patients to investigate the expression of genes related to APP-processing [(β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), and a disintegrin and metalloproteinase family 10 (ADAM10) and 17 (ADAM17)] and the epigenetic genes sirtuin (SIRT)1-3, which regulate Aβ production. Read More

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http://dx.doi.org/10.2174/1567205015666181109103742DOI Listing
January 2019
8 Reads

Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.

Curr Alzheimer Res 2019 ;16(1):8-18

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: Preclinical and clinical evidence suggests that elderly individuals are at increased risk of cognitive decline after general anesthesia. General anesthesia is also believed to be a risk factor for Postoperative Cognitive Dysfunction (POCD) and Alzheimer's Disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. Read More

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http://dx.doi.org/10.2174/1567205015666181031145045DOI Listing
January 2019
50 Reads

Asymptomatic Carriers of Presenilin-1 E318G Variant Show no Cerebrospinal Fluid Biochemical Signs Suggestive of Alzheimer's disease in a Family with Late-onset Dementia.

Curr Alzheimer Res 2019 ;16(1):1-7

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20156, Milan, Italy.

Background: Presenilin-1 (PSEN-1) is a component of the γ-secretase complex involved in β-amyloid Precursor Protein (AβPP) processing. Usually, Alzheimer's disease (AD)-linked mutations in the PSEN-1 gene lead to the early onset and increase the production of the aggregation-prone peptide Aβ42. However, the PSEN-1 E318G variant has an unclear pathogenic role and is recently reported as a genetic risk factor for AD. Read More

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http://dx.doi.org/10.2174/1567205015666181031150345DOI Listing
January 2019
33 Reads

Current State of Saliva Biomarkers for Aging and Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(1):56-66

CSIRO Health and Biosecurity, Future Science Platforms Probing Biosystems, Adelaide, South Australia 5000, Australia.

Introduction: Aging is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases such as Alzheimer's Disease (AD). AD is a progressive degenerative disorder of the brain and is the most common form of dementia.

Methods: To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. Read More

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http://dx.doi.org/10.2174/1567205015666181022094924DOI Listing
January 2019
6 Reads

Brain Network Connectivity Mediates Education-related Cognitive Performance in Healthy Elderly Adults.

Curr Alzheimer Res 2019 ;16(1):19-28

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Background: Among the protective factors for cognitive decline related to aging and Alzheimer's disease, education level is one of the most prominent. However, the mechanisms underlying the protective effects of education on cognition remain to be elucidated. In this study, we aimed to systematically assess the role of Functional Connectivity (FC) of resting-state brain networks playing in the cognition-protection effect of education. Read More

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http://dx.doi.org/10.2174/1567205015666181022094158DOI Listing
January 2019
28 Reads

Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway.

Curr Alzheimer Res 2019 ;16(1):39-48

Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guiyang 550004, China.

Background: β-amyloid (Aβ) aggregation plays an important role in the pathogenesis of Alzheimer's disease (AD), and astrocytes can significantly inhibit Aβ aggregation. Astrocytic α7 Neuronal Nicotinic Acetylcholine Receptor (nAChR) upregulation detected in the AD brains is closely associated with Aβ deposits. However, the relationships between the astrocytic α7 nAChRs and Aβ aggregation remain unclear. Read More

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http://www.eurekaselect.com/166479/article
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http://dx.doi.org/10.2174/1567205015666181022093359DOI Listing
January 2019
7 Reads

[F]-florbetaben PET/CT Imaging in the Alzheimer's Disease Mouse Model APPswe/PS1dE9.

Curr Alzheimer Res 2019 ;16(1):49-55

Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.

Background: Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of Alzheimer's disease (AD). In preclinical research, [F]-florbetaben-PET has already been used to test the amyloid-lowering potential of new drugs, both in humans and in transgenic models of cerebral amyloidosis. The aim of this study was to characterize the spatial pattern of cerebral uptake of [F]-florbetaben in the APPswe/ PS1dE9 mouse model of AD in comparison to histologically determined number and size of cerebral Aβ plaques. Read More

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http://dx.doi.org/10.2174/1567205015666181022095904DOI Listing
January 2019
17 Reads

Visual Event-Related Potentials in Mild Cognitive Impairment and Alzheimer's Disease: A Literature Review.

Curr Alzheimer Res 2019 ;16(1):67-89

Faculty of Medicine, University of Ottawa, Canada, Bruyère Research Institute, & Carleton University, Ottawa, Canada.

Background: Cognitive deficits are correlated with increasing age and become more pronounced for people with mild cognitive impairment (MCI) and dementia caused by Alzheimer's disease (AD). Conventional methods to diagnose cognitive decline (i.e. Read More

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http://dx.doi.org/10.2174/1567205015666181022101036DOI Listing
January 2019
7 Reads

The Implications of Autophagy in Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(14):1283-1296

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

The pathogenic mechanisms of Alzheimer's Disease (AD) involve the deposition of abnormally misfolded proteins, amyloid β protein (Aβ) and tau protein. Aβ comprises senile plaques, and tau aggregates form Neurofibrillary Tangles (NFTs), both of which are hallmarks of AD. Autophagy is the main conserved pathway for the degeneration of aggregated proteins, Aβ, tau and dysfunctional organelles in the cell. Read More

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http://dx.doi.org/10.2174/1567205015666181004143432DOI Listing
January 2018
3 Reads

Asymmetric Changes in Limbic Cortex and Planum Temporale in Patients with Alzheimer Disease.

Curr Alzheimer Res 2018 ;15(14):1361-1368

Institute of Anatomy, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic.

Background: There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the numbers of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Read More

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http://dx.doi.org/10.2174/1567205015666181004142659DOI Listing
January 2018
3 Reads

Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry.

Curr Alzheimer Res 2018 ;15(14):1322-1330

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

Introduction: Patients with dementia may be at a higher risk for death from stroke. We aimed to describe characteristics of dementia patients that died from ischemic stroke (IS) in Sweden.

Methods: A retrospective longitudinal analysis of prospectively collected data of patients registered into the Swedish Dementia Registry was conducted. Read More

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http://dx.doi.org/10.2174/1567205015666181002134155DOI Listing
January 2018
5 Reads

Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease.

Curr Alzheimer Res 2018 ;15(14):1354-1360

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Cerebrovascular pathologies and hypertension could play a vital role in Alzheimer disease (AD) progression. However, whether cerebrovascular pathologies and hypertension accelerate the AD progression through an independent or interaction effect is unknown.

Objective: To investigate the effect of the interactions of cerebrovascular pathologies and hypertension on AD progression. Read More

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http://dx.doi.org/10.2174/1567205015666181002141013DOI Listing
January 2018
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Alzheimer's Disease: Physical Activities as an Effective Intervention Tool - A Mini-Review.

Curr Alzheimer Res 2019 ;16(2):166-171

Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.

Background: There are a few risk factors which definitely have an impact on the development of Alzheimer's disease (AD). Those include genetics, gender, age, diabetes, head injuries, and lifestyle. Physical activity together with a healthy diet is part of people's lifestyle. Read More

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http://dx.doi.org/10.2174/1567205015666181002132021DOI Listing
January 2019
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Global View on Alzheimer's Disease and Diabetes Mellitus: Threats, Risks and Treatment Alzheimer's Disease and Diabetes Mellitus.

Curr Alzheimer Res 2018 ;15(14):1277-1282

Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.

The incidence of both diabetes and Alzheimer's disease (AD) is increasing and is becoming a social and economic threat worldwide. Recent research studies indicate that both diseases share some pathophysiological features and that specifically, Type 2 Diabetes Mellitus (T2DM) is a risk factor of Alzheimer's disease. The aim of this study is to explore the relationship between diabetes mellitus and AD, explore the efficacy of selected drugs on patients with diabetes and AD, and compare the relative risk of diabetes for Alzheimer's disease within different clinical studies. Read More

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http://dx.doi.org/10.2174/1567205015666180925110222DOI Listing
January 2018
2 Reads