1,432 results match your criteria Current Alzheimer Research [Journal]


Impact of a clinical decision support tool on dementia diagnostics in memory clinics: The PredictND validation study.

Curr Alzheimer Res 2019 01 3. Epub 2019 Jan 3.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen. Denmark.

Background: Determining the underlying etiology of dementia can be challenging. Computer-based clinical decision support systems (CDSS) have the potential to provide objective comparison of data and assist clinicians.

Objectives: To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnosis of dementia in memory clinics. Read More

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http://www.eurekaselect.com/168748/article
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http://dx.doi.org/10.2174/1567205016666190103152425DOI Listing
January 2019
5 Reads
3.889 Impact Factor

Identify compounds's target against Alzheimer's disease based on silico approach.

Curr Alzheimer Res 2019 Jan 3. Epub 2019 Jan 3.

School of Life Sciences, Shanghai University, Shanghai 200444. China.

Background: Alzheimer's disease swept every corner of the globe and the number of patients worldwide has been rising. At present, there are as many as 30 million people with Alzheimer's disease in the world, and it is expected to exceed 80 million people by 2050. Consequently, the study of Alzheimer's drugs has become one of the most popular medical topics. Read More

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http://dx.doi.org/10.2174/1567205016666190103154855DOI Listing
January 2019
6 Reads

Abnormal Sleep Behaviours Across the Spectrum of Alzheimer's Disease Severity: Influence of APOE Genotypes and Lewy Bodies.

Curr Alzheimer Res 2019 Jan 3. Epub 2019 Jan 3.

Keenan Research Centre for Biomedical Research, the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, ON. Canada.

Background: The Apolipoprotein (APOE) ε4 allele is a well-known risk factor for Alzheimer's Disease (AD), and sleep disturbances are commonly associated with AD. However, few studies have investigated the relationship between APOE ε4 and abnormal sleep patterns (N+) in AD.

Objective: To examine the relationship between APOE genotype, Lewy body pathology, and abnormal sleep patterns in a large group of subjects with known AD load evaluated upon autopsy. Read More

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http://dx.doi.org/10.2174/1567205016666190103161034DOI Listing
January 2019
3 Reads

Organotypic brain slices of ADULT transgenic mice: a tool to study Alzheimer´s disease.

Authors:
Christian Humpel

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Innsbruck. Austria.

Transgenic mice have been extensively used to study the Alzheimer pathology. In order to reduce, refine and replace (3Rs) the number of animals, ex vivo cultures are used and optimized. Organotypic brain slices are the most potent ex vivo slice culture models, keeping the 3-dimensional structure of the brain and being closest to the in vivo situation. Read More

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http://dx.doi.org/10.2174/1567205016666181212153138DOI Listing
December 2018
1 Read

The temporal relationship between pain intensity and pain interference and incident dementia.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461 . United States.

Background: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown.

Objective: We aimed to evaluate the associations of pain intensity and pain interference with incident dementia in a community-based sample of older adults. Read More

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http://dx.doi.org/10.2174/1567205016666181212162424DOI Listing
December 2018
3 Reads
3.889 Impact Factor

Outcomes of perilla seed oil as an additional neuroprotective therapy in patients with mild to moderate dementia: a randomized control trial.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Thammasat University - Chulabhron International College of Medicine, Klonglaung, Pathum Thani. Thailand.

Background: Dementia is a common medical disorder in elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. Read More

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http://dx.doi.org/10.2174/1567205016666181212153720DOI Listing
December 2018
1 Read

Down-Regulation Of Mir-107 Worsen Spatial Memory By Suppressing SYK Expression And Inactivating NF-ΚB Signaling Pathway.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Qingdao Mental Health Center, Qingdao 266000, Shandong. China.

Background:Alzheimer disease (AD) is a chronic progressive neurodegenerative disorder in central nervous system seen.

Objective: We aimed to study the miR-107 in Alzheimer's Disease (AD) pathology through regulating SYK and NF-κB signaling pathway.

Method: Bioinformatics analysis was performed to screen NF-κB signaling pathway and differentially expressed genes. Read More

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http://dx.doi.org/10.2174/1567205016666181212154347DOI Listing
December 2018
1 Read

Computational and in-vitro validation of natural molecules as potential Acetylcholinesterase inhibitors and neuroprotective agents.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh - 173234. India.

Background: Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is to identify new and safer 'disease-modifying drugs'.

Methods: Herein, we screened 646 small molecules of natural origin having reported pharmacological and functional values through in-silico docking studies to predict safer neuromodulatory molecules with potential to modulate acetylcholine metabolism. Read More

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http://dx.doi.org/10.2174/1567205016666181212155147DOI Listing
December 2018
2 Reads

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart. Australia.

Background: Images of amyloid-β pathology characteristic of Alzheimer's disease are difficult to consistently and accurately segment, due to diffuse deposit boundaries and imaging variations.

Methods: We evaluated the performance of ImageSURF, our open-source ImageJ plugin, which considers a range of image derivatives to train image classifiers. We compared ImageSURF to standard image thresholding to assess its reproducibility, accuracy and generalizability when used on fluorescence images of amyloid pathology. Read More

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http://dx.doi.org/10.2174/1567205016666181212152622DOI Listing
December 2018
1 Read
3.889 Impact Factor

A novel cell-based β-secretase enzymatic assay for Alzheimer's Disease.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3. Canada.

Background: Deposition of the amyloid β protein (Aβ) into neuritic plaques is the neuropathological hallmark of Alzheimer's Disease (AD). Aβ is generated through the cleavage of the Amyloid Precursor Protein (APP) by β-secretase and γ-secretase. Currently, the evaluation of APP cleavage by β-secretase in experimental settings has largely depended on models that do not replicate the physiological conditions of this process. Read More

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http://dx.doi.org/10.2174/1567205016666181212151540DOI Listing
December 2018
10 Reads

One-year outcome of Shanghai mild cognitive impairment cohort study.

Curr Alzheimer Res 2018 Nov 28. Epub 2018 Nov 28.

Institute of Neurology Huashan Hospital Fudan University Shanghai. China.

Background & Objective: The purpose of this study is to identify the risk factors associated with the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia for the early detection of AD.

Methods: The study comprised a prospective cohort study that included 400 MCI subjects with annual follow-ups for 3 years.

Results: During the first 12 months' follow-up, 42 subjects converted to Alzheimer's dementia (21 probable AD and 21 possible AD), two subjects converted to other types of dementia and 56 subjects lost follow. Read More

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http://www.eurekaselect.com/167828/article
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http://dx.doi.org/10.2174/1567205016666181128151144DOI Listing
November 2018
14 Reads

Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood.

Curr Alzheimer Res 2019 ;16(1):29-38

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakon Pathom, Thailand.

Background: Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the Amyloid Precursor Protein (APP)-cleaving enzymes directly affect the formation of Amyloid Beta (Aβ) plaques, a neuropathological hallmark of AD.

Objective: We used peripheral blood from AD patients to investigate the expression of genes related to APP-processing [(β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), and a disintegrin and metalloproteinase family 10 (ADAM10) and 17 (ADAM17)] and the epigenetic genes sirtuin (SIRT)1-3, which regulate Aβ production. Read More

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http://dx.doi.org/10.2174/1567205015666181109103742DOI Listing
January 2019
8 Reads

Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.

Curr Alzheimer Res 2019 ;16(1):8-18

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: Preclinical and clinical evidence suggests that elderly individuals are at increased risk of cognitive decline after general anesthesia. General anesthesia is also believed to be a risk factor for Postoperative Cognitive Dysfunction (POCD) and Alzheimer's Disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. Read More

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http://dx.doi.org/10.2174/1567205015666181031145045DOI Listing
January 2019
40 Reads

Asymptomatic Carriers of Presenilin-1 E318G Variant Show no Cerebrospinal Fluid Biochemical Signs Suggestive of Alzheimer's disease in a Family with Late-onset Dementia.

Curr Alzheimer Res 2019 ;16(1):1-7

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20156, Milan, Italy.

Background: Presenilin-1 (PSEN-1) is a component of the γ-secretase complex involved in β-amyloid Precursor Protein (AβPP) processing. Usually, Alzheimer's disease (AD)-linked mutations in the PSEN-1 gene lead to the early onset and increase the production of the aggregation-prone peptide Aβ42. However, the PSEN-1 E318G variant has an unclear pathogenic role and is recently reported as a genetic risk factor for AD. Read More

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http://dx.doi.org/10.2174/1567205015666181031150345DOI Listing
January 2019
25 Reads

Current State of Saliva Biomarkers for Aging and Alzheimer's Disease.

Curr Alzheimer Res 2019 ;16(1):56-66

CSIRO Health and Biosecurity, Future Science Platforms Probing Biosystems, Adelaide, South Australia 5000, Australia.

Introduction: Aging is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases such as Alzheimer's Disease (AD). AD is a progressive degenerative disorder of the brain and is the most common form of dementia.

Methods: To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. Read More

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http://dx.doi.org/10.2174/1567205015666181022094924DOI Listing
January 2019
6 Reads

Brain Network Connectivity Mediates Education-related Cognitive Performance in Healthy Elderly Adults.

Curr Alzheimer Res 2019 ;16(1):19-28

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Background: Among the protective factors for cognitive decline related to aging and Alzheimer's disease, education level is one of the most prominent. However, the mechanisms underlying the protective effects of education on cognition remain to be elucidated. In this study, we aimed to systematically assess the role of Functional Connectivity (FC) of resting-state brain networks playing in the cognition-protection effect of education. Read More

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http://dx.doi.org/10.2174/1567205015666181022094158DOI Listing
January 2019
21 Reads

Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway.

Curr Alzheimer Res 2019 ;16(1):39-48

Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guiyang 550004, China.

Background: β-amyloid (Aβ) aggregation plays an important role in the pathogenesis of Alzheimer's disease (AD), and astrocytes can significantly inhibit Aβ aggregation. Astrocytic α7 Neuronal Nicotinic Acetylcholine Receptor (nAChR) upregulation detected in the AD brains is closely associated with Aβ deposits. However, the relationships between the astrocytic α7 nAChRs and Aβ aggregation remain unclear. Read More

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http://www.eurekaselect.com/166479/article
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http://dx.doi.org/10.2174/1567205015666181022093359DOI Listing
January 2019
6 Reads

[F]-florbetaben PET/CT Imaging in the Alzheimer's Disease Mouse Model APPswe/PS1dE9.

Curr Alzheimer Res 2019 ;16(1):49-55

Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.

Background: Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of Alzheimer's disease (AD). In preclinical research, [F]-florbetaben-PET has already been used to test the amyloid-lowering potential of new drugs, both in humans and in transgenic models of cerebral amyloidosis. The aim of this study was to characterize the spatial pattern of cerebral uptake of [F]-florbetaben in the APPswe/ PS1dE9 mouse model of AD in comparison to histologically determined number and size of cerebral Aβ plaques. Read More

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http://dx.doi.org/10.2174/1567205015666181022095904DOI Listing
January 2019
15 Reads

Visual Event-Related Potentials in Mild Cognitive Impairment and Alzheimer's Disease: A Literature Review.

Curr Alzheimer Res 2019 ;16(1):67-89

Faculty of Medicine, University of Ottawa, Canada, Bruyère Research Institute, & Carleton University, Ottawa, Canada.

Background: Cognitive deficits are correlated with increasing age and become more pronounced for people with mild cognitive impairment (MCI) and dementia caused by Alzheimer's disease (AD). Conventional methods to diagnose cognitive decline (i.e. Read More

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http://dx.doi.org/10.2174/1567205015666181022101036DOI Listing
January 2019
7 Reads

The Implications of Autophagy in Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(14):1283-1296

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

The pathogenic mechanisms of Alzheimer's Disease (AD) involve the deposition of abnormally misfolded proteins, amyloid β protein (Aβ) and tau protein. Aβ comprises senile plaques, and tau aggregates form Neurofibrillary Tangles (NFTs), both of which are hallmarks of AD. Autophagy is the main conserved pathway for the degeneration of aggregated proteins, Aβ, tau and dysfunctional organelles in the cell. Read More

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http://dx.doi.org/10.2174/1567205015666181004143432DOI Listing
January 2018
3 Reads

Asymmetric Changes in Limbic Cortex and Planum Temporale in Patients with Alzheimer Disease.

Curr Alzheimer Res 2018 ;15(14):1361-1368

Institute of Anatomy, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic.

Background: There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the numbers of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Read More

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http://dx.doi.org/10.2174/1567205015666181004142659DOI Listing
January 2018
3 Reads

Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry.

Curr Alzheimer Res 2018 ;15(14):1322-1330

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

Introduction: Patients with dementia may be at a higher risk for death from stroke. We aimed to describe characteristics of dementia patients that died from ischemic stroke (IS) in Sweden.

Methods: A retrospective longitudinal analysis of prospectively collected data of patients registered into the Swedish Dementia Registry was conducted. Read More

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http://dx.doi.org/10.2174/1567205015666181002134155DOI Listing
January 2018
4 Reads

Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease.

Curr Alzheimer Res 2018 ;15(14):1354-1360

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Cerebrovascular pathologies and hypertension could play a vital role in Alzheimer disease (AD) progression. However, whether cerebrovascular pathologies and hypertension accelerate the AD progression through an independent or interaction effect is unknown.

Objective: To investigate the effect of the interactions of cerebrovascular pathologies and hypertension on AD progression. Read More

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http://dx.doi.org/10.2174/1567205015666181002141013DOI Listing
January 2018
3 Reads

Alzheimer's Disease: Physical Activities as an Effective Intervention Tool - A Mini-Review.

Curr Alzheimer Res 2018 Oct 2. Epub 2018 Oct 2.

Biomedical Research Centrum, University Hospital Hradec Kralove, Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove. Czech Republic.

Background: There are a few risk factors which definitely have an impact on the development of Alzheimer's disease (AD). Those include genetics, gender, age, diabetes, head injuries, and lifestyle. Physical activity together with healthy diet is part of people's lifestyle. Read More

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http://dx.doi.org/10.2174/1567205015666181002132021DOI Listing
October 2018
2 Reads

Global View on Alzheimer's Disease and Diabetes Mellitus: Threats, Risks and Treatment Alzheimer's Disease and Diabetes Mellitus.

Curr Alzheimer Res 2018 ;15(14):1277-1282

Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.

The incidence of both diabetes and Alzheimer's disease (AD) is increasing and is becoming a social and economic threat worldwide. Recent research studies indicate that both diseases share some pathophysiological features and that specifically, Type 2 Diabetes Mellitus (T2DM) is a risk factor of Alzheimer's disease. The aim of this study is to explore the relationship between diabetes mellitus and AD, explore the efficacy of selected drugs on patients with diabetes and AD, and compare the relative risk of diabetes for Alzheimer's disease within different clinical studies. Read More

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http://dx.doi.org/10.2174/1567205015666180925110222DOI Listing
January 2018
2 Reads

Assessing Everyday Activities Across the Dementia Spectrum with the Amsterdam IADL Questionnaire.

Curr Alzheimer Res 2018 ;15(13):1261-1266

Department of Developmental Psychology, University de Santiago de Compostela, A Coruna, Galicia, Spain.

Background: Instrumental activities of daily living (IADL) are complex activities which involve multiple cognitive processes, and which are expected to be susceptible to the early effects of cognitive impairment. Informant-based questionnaires are the most common tools used to assess IADL performance in dementia, but must be adjusted for use in early stages of impairment.

Objective: To investigate the differences in IADL on the continuum of cognitive decline (i. Read More

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http://dx.doi.org/10.2174/1567205015666180925113411DOI Listing
January 2018
1 Read

Alzheimer's Disease: Special Focus on the Efficacy of Computer-Based Training Programs - A Mini-Review.

Curr Alzheimer Res 2018 ;15(13):1213-1219

Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic.

Background: At present, the number of older people is growing, especially in the developed countries where the living conditions enable a longer life expectancy. However, the higher age may result in the aging diseases such as dementia out which Alzheimer's disease (AD) is the most frequent. Nevertheless, to maintain them both physically and mentally active, more assistance is required. Read More

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http://dx.doi.org/10.2174/1567205015666180925105902DOI Listing
January 2018
8 Reads

Crossed Cerebellar Diaschisis in Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(13):1267-1275

Department of Neurology, Alzheimer Research Center, University of Groningen, University Medical Center, Groningen, Netherlands.

Background: We describe the phenomenon of crossed cerebellar diaschisis (CCD) in four subjects diagnosed with Alzheimer's disease (AD) according to the National Institute on Aging - Alzheimer Association (NIA-AA) criteria, in combination with 18F-FDG PET and 11C-PiB PET imaging.

Methods: 18F-FDG PET showed a pattern of cerebral metabolism with relative decrease most prominent in the frontal-parietal cortex of the left hemisphere and crossed hypometabolism of the right cerebellum. 11C-PiB PET showed symmetrical amyloid accumulation, but a lower relative tracer delivery (a surrogate of relative cerebral blood flow) in the left hemisphere. Read More

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http://dx.doi.org/10.2174/1567205015666180913102615DOI Listing
January 2018
1 Read
3.889 Impact Factor

Mapping Exchangeable Protons to Monitor Protein Alterations in the Brain of an Alzheimer's Disease Mouse Model by Using MRI.

Curr Alzheimer Res 2018 ;15(14):1343-1353

Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-Gu, Seoul 05278, Korea.

Objective: The study aimed to investigate exchangeable proton signals of Aβ proteins of the brains of Alzheimer's disease (AD) model mice by using a chemical exchange-sensitive spin-lock (CESL) MR imaging technique.

Method: Eight non-transgenic (Tg) mice (5 young and 3 old) and twelve Tg-APPswe/PSdE9 mice (5 young and 7 old) were used in this study. CESL Z-spectra were obtained by using two saturation powers, which were ω1 = 25 Hz with TSL = 3. Read More

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http://dx.doi.org/10.2174/1567205015666180911143518DOI Listing
January 2018
1 Read

A Mesenchymal Stem Cell Line Transplantation Improves Neurological Function and Angiogenesis in Intraventricular Amyloid β-Infused Rats.

Curr Alzheimer Res 2018 ;15(14):1331-1342

Department of Laboratory Medicine, Shimane University School of Medicine, Ringgold Standard Institution, 89-1 Enya Cho, Izumo, Shimane 693-8501, Japan.

Background: Mesenchymal stem cell transplantation is demonstrated to improve neurological performance in neurodegenerative diseases including Alzheimer's disease.

Objective: The objective of this study is to understand the underlying mechanism of such improvement.

Methods: Amyloid β (Aβ) peptide was infused into the lateral ventricle of adult Wister rats using the osmotic pump. Read More

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http://dx.doi.org/10.2174/1567205015666180911145159DOI Listing
January 2018
5 Reads
3.890 Impact Factor

Event-related Potentials Improve the Efficiency of Cerebrospinal Fluid Biomarkers for Differential Diagnosis of Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(13):1244-1260

Department of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.

Introduction: The pathological process of Alzheimer's disease (AD) in the brain likely begins 20-30 years earlier than the emergence of its first clinical symptoms and symptoms of AD often overlap with the symptoms of other primary causes of dementia. Therefore, it is crucially important to improve early and differential diagnosis of the disease. Event-related potentials (ERP) measured non-invasively by electroencephalography have shown diagnostic potential in AD. Read More

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http://dx.doi.org/10.2174/1567205015666180911151116DOI Listing
January 2018
11 Reads
3.890 Impact Factor

The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View.

Curr Alzheimer Res 2018 ;15(13):1191-1212

Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, H-6726 Szeged, Hungary.

Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis and depend on specific protein-lipid interactions. Read More

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http://dx.doi.org/10.2174/1567205015666180911151716DOI Listing
January 2018
1 Read

Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.

Curr Alzheimer Res 2018 ;15(13):1220-1230

Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

Background: Microdose lithium is protective against Alzheimer's disease (AD), although the precise mechanisms through which its protective effects are conferred remain unclear.

Objective: To further examine the effects during the earliest stages of Aβ pathology, we evaluated whether NP03, a microdose lithium formulation, modulates Aβ-mediated oxidative damage and neuroinflammation when applied to a rat transgenic model of AD-like amyloidosis overexpressing amyloid precursor protein (APP).

Method: McGill-R-Thy1-APP transgenic rats and wild-type littermates were treated with NP03 or vehicle formulation for 8 weeks beginning at 3 months of age - a phase preceding Aβ plaque deposition in the transgenic rats. Read More

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http://dx.doi.org/10.2174/1567205015666180904154446DOI Listing
January 2018
5 Reads

Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(13):1179-1190

Biomedical Gerontology Program of the School of Medicine, Pontifical Catholic University of Rio Grande do Sul (IGG-PUCRS), Porto Alegre/RS, Brazil.

The role of diet and gut microbiota in the pathophysiology of neurodegenerative diseases, such as Alzheimer's, has recently come under intense investigation. Studies suggest that human gut microbiota may contribute to the modulation of several neurochemical and neurometabolic pathways, through complex systems that interact and interconnect with the central nervous system. The brain and intestine form a bidirectional communication axis, or vice versa, they form an axis through bi-directional communication between endocrine and complex immune systems, involving neurotransmitters and hormones. Read More

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http://dx.doi.org/10.2174/1567205015666180904155908DOI Listing
January 2018
6 Reads

Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates.

Curr Alzheimer Res 2018 ;15(14):1304-1321

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China.

Background: Formaldehyde (FA) has been implicated in Alzheimer's disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) and tau protein in vitro. Higher levels of FA have also been found in patients with greater cognitive impairment and in AD patient brains.

Objective: To directly evaluate the effect of chronically elevated FA levels on the primate brain with respect to AD pathological markers. Read More

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http://dx.doi.org/10.2174/1567205015666180904150118DOI Listing
January 2018
26 Reads

Missing Uniform Costs Classification for Alzheimer's Disease Treatment and Care.

Curr Alzheimer Res 2018 ;15(14):1297-1303

Faculty of Informatics and Management, Centre of Basic and Applied Research, University of Hradec Kralove, Hradec Kralove, Czech Republic.

Background: The importance of the issue of the economic burden of treatment and care for people with dementia is crucial in the developed countries. The European Union and other developed countries are trying to improve the course of aging population which leads to rising costs. Their uniform registration is also one of the objectives of the developed countries' strategic plans to fight dementia. Read More

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http://dx.doi.org/10.2174/1567205015666180831103018DOI Listing
January 2018
2 Reads

Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer's Disease: A Phase 2, Open-Label Extension Study.

Curr Alzheimer Res 2018 ;15(13):1231-1243

Janssen Research & Development, Pennington, NJ 08534, United States.

Background: Bapineuzumab is a humanized anti-amyloid-beta (Aβ) monoclonal antibody directed at lowering the cerebral Aβ deposit in Alzheimer's disease (AD).

Objective: This phase 2, open-label extension (OLE) study evaluated long-term safety and efficacy of bapineuzumab in patients with the mild-to-moderate AD.

Methods: Patients (58-78 years) who completed either of two randomized, placebo-controlled, doubleblind studies (subcutaneous [SC] single-dose-escalation, or intravenous (IV) multiple-ascending-dose)) entered the OLE. Read More

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http://dx.doi.org/10.2174/1567205015666180821114813DOI Listing
January 2018
14 Reads

Ezrin Expression is Increased During Disease Progression in a Tauopathy Mouse Model and Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(12):1086-1095

Department of Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, MI, United States.

Background: The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand the pathogenesis of tau-related pathological hallmarks and/or cellular stress responses associated with tauopathy. These studies, however, need to be conducted taking into consideration brain region specificity and stage of neurodegeneration in order to provide insights about the pathological role of the identified proteins. Read More

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http://dx.doi.org/10.2174/1567205015666180813152043DOI Listing
January 2018
3 Reads

Insights into the Drug Repositioning Applied to the Alzheimer's Disease Treatment and Future Perspectives.

Curr Alzheimer Res 2018 ;15(12):1161-1178

Department of Chemistry, Federal University of Lavras, Lavras/MG, 37200-000, Brazil.

Introduction: Alzheimer's disease is known to be a chronic disease, with an estimated prevalence of about 10-30%, considering the population over 60 years of age. Most patients with this disorder (> 95%) present the sporadic form, being characterized by a late onset (80-90 years of age), and it is the consequence of the failure to clear the amyloid-β (Aβ) peptide from the interstices of the brain. Significant numbers of genetic risk factors for the sporadic disease have been researched. Read More

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http://dx.doi.org/10.2174/1567205015666180813150703DOI Listing
January 2018
13 Reads

Deformation-based Statistical Shape Analysis of the Corpus Callosum in Mild Cognitive Impairment and Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(12):1151-1160

Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Objective: In this study, we investigated the influence that the pathology of Alzheimer's disease (AD) exerts upon the corpus callosum (CC) using a total of 325 mild cognitive impairment (MCI) subjects, 155 AD subjects, and 185 healthy control (HC) subjects.

Method: Regionally-specific morphological CC abnormalities, as induced by AD, were quantified using a large deformation diffeomorphic metric curve mapping based statistical shape analysis pipeline. We also quantified the association between the CC shape phenotype and two cognitive measures; the Mini Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Behavior Section (ADAS-cog). Read More

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http://dx.doi.org/10.2174/1567205015666180813145935DOI Listing
January 2018
1 Read

Oral and Written Naming in Alzheimer's Disease: A Longitudinal Study.

Curr Alzheimer Res 2018 ;15(12):1142-1150

University of Oviedo, Asturias, Spain, Hospital of Cabuenes, Asturias, Spain.

Background: The expressive difficulties in patients with Alzheimer's dementia have been extensively studied, mainly in oral language. However, the deterioration of their writing processes has received much less attention.

Objective: The present study aims to examine the decline of the performance of patients with Alzheimer's disease in both oral and written picture-naming tasks. Read More

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http://dx.doi.org/10.2174/1567205015666180813145402DOI Listing
January 2018
2 Reads

Probiotic Supplementation in Patients with Alzheimer's Dementia - An Explorative Intervention Study.

Curr Alzheimer Res 2018 ;15(12):1106-1113

Division of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

Background: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer's disease.

Objective: The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation.

Methods: In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76. Read More

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http://dx.doi.org/10.2174/1389200219666180813144834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340155PMC
January 2018
8 Reads

Improving Cognition through Dance in Older Filipinos with Mild Cognitive Impairment.

Curr Alzheimer Res 2018 ;15(12):1136-1141

Department of Neurology, Danish Dementia Research Center, Rigshospitalet, University of Copenhagen, Kobenhavn, Denmark.

Background: People with mild cognitive impairment (MCI) are considered a high-risk population for developing dementia and therefore potential targets for preventive interventions. So far, no pharmacological interventions have proven to be effective. Latest evidence has laid the groundwork for the hypothesis that dancing can have beneficial effect on cognition by improving neuroplasticity. Read More

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http://www.eurekaselect.com/164229/article
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http://dx.doi.org/10.2174/1567205015666180801112428DOI Listing
January 2018
15 Reads

Anti-α4β1 Integrin Antibodies Attenuated Brain Inflammatory Changes in a Mouse Model of Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(12):1123-1135

Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota, ND 58202, United States.

Background: Alzheimer's disease (AD) is associated with age-associated central nervous system degeneration and dementia. This decline in the function correlates with deposition of Aβ peptide containing plaques and associated reactive gliosis. The inflammatory phenotype of microglia, in particular, is often considered detrimental to cognitive function in AD. Read More

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http://dx.doi.org/10.2174/1567205015666180801111033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302348PMC
January 2018
4 Reads

Influence of Early Life Lead (Pb) Exposure on α-Synuclein, GSK-3β and Caspase-3 Mediated Tauopathy: Implications on Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(12):1114-1122

George & Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, United States.

Background: Previously we have shown that developmental exposure to the heavy metal lead (Pb) resulted in latent cognitive impairment, upregulation of biomarkers and pathology associated with both the tau and amyloid pathways, however, the impact on Alpha Synuclein (α-Syn) and its relationship to these pathways and their connection to cognitive performance warrant further elucidation.

Objective: The present study determined the impact of developmental Pb exposure on the α-Syn pathways in a mouse model knock-out (KO) for murine tau gene and in differentiated human neuroblastoma SHSY5Y cell line exposed to a series of Pb concentrations.

Methods: Western blot analysis and RT-PCR were used to assess the levels of intermediates in the tau and α-Syn pathways following postnatal Pb exposure on aged mice lacking tau gene and in differentiated SHSY5Y cells on day 3 and day 6 after the Pb exposure had ceased. Read More

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http://dx.doi.org/10.2174/1567205015666180801095925DOI Listing
January 2018
3 Reads

Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

Curr Alzheimer Res 2018 ;15(12):1096-1105

Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.

Background: The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more pharmacophoric moieties that are known to enable interaction with the selected molecular targets.

Methods: All compounds were tested for their inhibitory activity on human AChE/BChE. Read More

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http://dx.doi.org/10.2174/1567205015666180711110750DOI Listing
January 2018
23 Reads

Beneficial Effect of Minimal Interference on Item Memory But Not on Source Memory in Alzheimer's Disease.

Curr Alzheimer Res 2018 ;15(11):1070-1076

Laboratoire de Psychologie des Pays de la Loire (EA 4638), Université de Nantes, Nantes, France.

Objectives: Research suggests beneficial effects of minimal interference on item memory in mild Alzheimer's disease (AD). We conducted a study to test whether these beneficial effects extend to source memory, i.e. Read More

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http://dx.doi.org/10.2174/1567205015666180711105242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162162PMC
January 2018
3 Reads

Progressive Spatial Memory Impairment, Brain Amyloid Deposition and Changes in Serum Amyloid Levels as a Function of Age in APPswe/PS1dE9 Mice.

Curr Alzheimer Res 2018 ;15(11):1053-1061

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.

Background: Mice co-expressing human amyloid precursor protein with the Swedish mutation (APPswe) and exon-9-deleted presenilin (PS1dE9) has become one of the most widely used mouse models for studying Alzheimer's disease (AD) pathogenesis and preclinical studies of AD therapeutic approaches.

Objective: In this study, we systematically investigated cognitive decline, amyloid-β (Aβ) deposition and cerebral or Aβ serum levels as well as the relationships among these measures in APPswe/PS1dE9 transgenic mice.

Method: APPswe/PS1dE9 mice were separated into four equal age cohorts (4, 6, 9, and 12 months). Read More

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http://dx.doi.org/10.2174/1567205015666180709112327DOI Listing
January 2018
18 Reads

Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia.

Curr Alzheimer Res 2018 ;15(11):1062-1069

Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.

Background: Type 2 diabetes mellitus (DM) has been shown to increase the risk for cognitive decline and dementia, such as Alzheimer disease (AD) and vascular dementia (VaD). In addition to AD and VaD, there may be a dementia subgroup associated with specific DM-related metabolic abnormalities rather than AD pathology or cerebrovascular disease, referred to as diabetes-related dementia (DrD).

Method: We studied 11C-PiB and 11C-PBB3 positron emission tomography (PET) in 31 subjects with DrD and 5 subjects with AD associated with DM to assess amyloid and tau deposits in the brain. Read More

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http://dx.doi.org/10.2174/1567205015666180709113338DOI Listing
January 2018
23 Reads

Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.

Curr Alzheimer Res 2018 ;15(11):1045-1052

Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei Province, China.

Background: Berberine (BBR) has neuroprotective effects on many brain diseases, including Alzheimer's disease (AD). Amyloid -beta (Aβ) senile plaque is the most classical pathological hallmarks of AD. Aβ produces from a sequential cleavage by β-secretase (beta-site amyloid precursor protein cleaving enzyme 1, BACE1) and γ -secretase. Read More

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http://dx.doi.org/10.2174/1567205015666180702105740DOI Listing
January 2018
5 Reads