1,374 results match your criteria Current Allergy and Asthma Reports[Journal]


Th9 Cells in Allergic Disease.

Curr Allergy Asthma Rep 2019 Mar 26;19(5):29. Epub 2019 Mar 26.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, 12120, Thailand.

Purposes Of Review: Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases.

Recent Findings: The effector Th9 cells differentiating from naïve T helper cells have recently been identified. Read More

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http://dx.doi.org/10.1007/s11882-019-0860-8DOI Listing
March 2019
3 Reads

Exosomes in Allergic Airway Diseases.

Curr Allergy Asthma Rep 2019 Mar 22;19(5):26. Epub 2019 Mar 22.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, 1900 University Boulevard, THT-433, Birmingham, AL, 35294, USA.

Purpose Of Review: This review will cover what is known regarding exosomes and allergy, and furthermore discuss novel mechanism of exosome-mediated immune modulation and metabolic regulation via the transfer of mitochondria.

Recent Findings: Exosomes are nano-sized extracellular vesicles (EVs) derived from the endosome that play a direct role in governing physiological and pathological conditions by transferring bioactive cargo such as proteins, enzymes, nucleic acids (miRNA, mRNA, DNA), and metabolites. Recent evidence suggest that exosomes may signal in autocrine but, most importantly, in paracrine and endocrine manner, being taken up by neighboring cells or carried to distant sites. Read More

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http://dx.doi.org/10.1007/s11882-019-0857-3DOI Listing

Microbial Adjuncts for Food Allergen Immunotherapy.

Curr Allergy Asthma Rep 2019 Mar 22;19(5):25. Epub 2019 Mar 22.

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place Box 1498, New York, NY, 10029, USA.

Purpose Of Review: Food allergen immunotherapy may benefit from adjunct therapies to enhance safety and efficacy. We review preclinical studies investigating the effects of probiotics and other microbial-based interventions on oral tolerance, describe the human clinical trial evidence thus far for microbial adjuncts, and discuss steps for translating research findings in this area to clinical therapy.

Recent Findings: Murine studies support that microbial-based interventions confer protection against sensitization and may augment treatment efficacy for food allergy. Read More

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http://dx.doi.org/10.1007/s11882-019-0859-1DOI Listing

Evaluating Penicillin Allergies Without Skin Testing.

Curr Allergy Asthma Rep 2019 Mar 22;19(5):27. Epub 2019 Mar 22.

Department of Allergy, Southern California Permanente Medical Group, Kaiser Permanente, 7060 Clairemont Mesa Blvd, San Diego, CA, 92111, USA.

Purpose Of Review: An unconfirmed penicillin allergy is known to confer significant risk to patients. Only a small minority of patients labeled with penicillin allergy will be confirmed to be hypersensitive with the current reference standard test, an oral amoxicillin therapeutic dose challenge. Skin testing has been recommended prior to oral challenges to reduce the risk of severe acute challenge reactions. Read More

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http://dx.doi.org/10.1007/s11882-019-0854-6DOI Listing

Contributions of Innate Lymphoid Cells in Chronic Rhinosinusitis.

Curr Allergy Asthma Rep 2019 Mar 22;19(5):28. Epub 2019 Mar 22.

Department of Otorhinolaryngology-Head & Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, 77030, USA.

Purpose Of Review: To review innate lymphoid cells (ILCs) and their role in chronic rhinosinusitis (CRS).

Recent Findings: The immune system consists of the innate and adaptive response. Until the recognition of ILCs, chronic inflammatory diseases were characterized by cytokines linked only to T helper cells. Read More

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http://dx.doi.org/10.1007/s11882-019-0861-7DOI Listing

Chlorhexidine Allergy: On the Rise and Often Overlooked.

Curr Allergy Asthma Rep 2019 Mar 14;19(5):23. Epub 2019 Mar 14.

Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital Gentofte, Kildegårdsvej 28, 2900, Hellerup, Denmark.

Purpose Of Review: In recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that can minimise the risk of both chlorhexidine sensitisation and allergy development and accidental re-exposure in patients with chlorhexidine allergy. Testing for chlorhexidine allergy is also discussed. Read More

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http://dx.doi.org/10.1007/s11882-019-0858-2DOI Listing
March 2019
1 Read

Osteitis in Chronic Rhinosinusitis.

Curr Allergy Asthma Rep 2019 Mar 14;19(5):24. Epub 2019 Mar 14.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Purpose Of Review: Osteitis is recognized as a common factor in recalcitrant chronic rhinosinusitis (CRS). There is evidence for the association of osteitis with revision surgeries and CRS severity, in terms of higher Lund-Mackay scores. This is a narrative review on the osteitis in CRS patients. Read More

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http://dx.doi.org/10.1007/s11882-019-0855-5DOI Listing
March 2019
3 Reads

Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.

Curr Allergy Asthma Rep 2019 Mar 11;19(4):22. Epub 2019 Mar 11.

Division of Allergy and Clinical Immunology, Henry Ford Health System, WSU School of Medicine, One Ford Place 4B, Detroit, MI, 48202, USA.

Purpose Of Review: The infant gut microbiota has become a focus of multiple epidemiologic and cohort studies. This microbiome is derived from the mother (via the vaginal canal, maternal skin contact, breastfeeding, and possibly in utero microbial transfer) and is likely influenced by multiple external factors. It is now believed by some experts that colonization and formation of the newborn and alterations of gut microbiota in children are dependent on earlier alterations of the microbiota of mothers during or perhaps even before pregnancy. Read More

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http://link.springer.com/10.1007/s11882-019-0851-9
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http://dx.doi.org/10.1007/s11882-019-0851-9DOI Listing
March 2019
9 Reads

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis.

Curr Allergy Asthma Rep 2019 Mar 11;19(4):21. Epub 2019 Mar 11.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave., CHS 62-132, Los Angeles, CA, 90095-1624, USA.

Purpose Of Review: Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence of S. Read More

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http://dx.doi.org/10.1007/s11882-019-0853-7DOI Listing
March 2019
9 Reads

BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?

Curr Allergy Asthma Rep 2019 Mar 11;19(4):20. Epub 2019 Mar 11.

Clinical Immunology and Allergy Division, University of São Paulo, R. Prof. Artur Ramos 178 ap.211A, Jd. América, São Paulo, SP, CEP: 01454-904, Brazil.

Purpose Of Review: The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.

Recent Findings: Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions. Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests. Read More

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http://dx.doi.org/10.1007/s11882-019-0852-8DOI Listing
March 2019
1 Read

Correction to: The Impact of Immunodeficiency on NK Cell Maturation and Function.

Curr Allergy Asthma Rep 2019 Mar 7;19(3):19. Epub 2019 Mar 7.

Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.

The section heading that reads PI3K100δ Deficiency should be corrected to read PI3K110δ Deficiency. Read More

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http://dx.doi.org/10.1007/s11882-019-0856-4DOI Listing
March 2019
1 Read

New and Potential Treatments for Atopic Dermatitis: Biologicals and Small Molecules.

Curr Allergy Asthma Rep 2019 Feb 28;19(3):18. Epub 2019 Feb 28.

Department of Allergy and Immunology, Hospital Quironsalud, Bilbao, Bizkaia, Spain.

Purpose Of Review: An update on new therapies currently approved or potentially useful in the future for the management of patients suffering moderate-to-severe atopic dermatitis.

Recent Findings: New pathogenic mechanisms involved in atopic dermatitis have permitted to propose novel therapeutic approaches devised to control the inflammatory process observed in involved cutaneous tissues by neutralizing mediators, cytokines, and their receptors. Recent research findings have disclosed important and previously unrecognized pathogenic mechanisms that have resulted in innovative targeted therapies, such as dupilumab, and potentially other biologicals and small molecules. Read More

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http://dx.doi.org/10.1007/s11882-019-0849-3DOI Listing
February 2019
5 Reads

Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions.

Curr Allergy Asthma Rep 2019 Feb 28;19(3):17. Epub 2019 Feb 28.

National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive MD-MR-01, Research Triangle Park, NC, 27709, USA.

Purpose Of Review: Allergen-antibody complexes are extremely valuable in describing the detailed molecular features of epitopes. This review summarizes insights gained from recently published co-structures and what obstacles impede the acquisition of further data.

Recent Findings: Structural epitope data helped define the epitopes of two anti-Fel d 1 antibodies undergoing phase I clinical trials, providing a greater level of detail than was possible through hydrogen-deuterium exchange protection studies. Read More

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http://link.springer.com/10.1007/s11882-019-0848-4
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http://dx.doi.org/10.1007/s11882-019-0848-4DOI Listing
February 2019
7 Reads

Emerging Therapeutics for Ocular Surface Disease.

Curr Allergy Asthma Rep 2019 Feb 28;19(3):16. Epub 2019 Feb 28.

Yeshiva University, New York, NY, USA.

Purpose Of Review: The purpose of this article is to review treatment advances in ocular allergy that include the treatment of the various signs and symptoms of the allergic inflammatory response of the ocular surface.

Recent Findings: Recent studies have demonstrated improved pharmacological effect of topical agents with artificial tears and cold compresses; brimonidine, a new ophthalmic decongestant which has demonstrated decreased rebound conjunctivitis; and potential use of contact lens and other novel delivery instruments to increase medication retention time. Currently, there have been limited advances in novel ophthalmic treatments. Read More

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http://dx.doi.org/10.1007/s11882-019-0844-8DOI Listing
February 2019
1 Read

Hypoallergenic Proteins for the Treatment of Food Allergy.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):15. Epub 2019 Feb 22.

School of Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 3330 Thurston Building, CB# 7280, Chapel Hill, NC, 27599-7280, USA.

Purpose Of Review: Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe side effects including anaphylaxis. Read More

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http://dx.doi.org/10.1007/s11882-019-0846-6DOI Listing
February 2019
1 Read

Clinical Guidelines on Chronic Rhinosinusitis in Children.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):14. Epub 2019 Feb 22.

Department of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Ave, CHS 62-237, Los Angeles, CA, 90095, USA.

Purpose Of Review: Pediatric chronic rhinosinusitis (CRS) is a prevalent problem that can elude diagnosis. In addition, given the burgeoning interest in pediatric sinonasal disease, treatment modalities are constantly evolving.

Recent Findings: The diagnosis of pediatric CRS is primarily based on clinical history and signs supported by objective findings (i. Read More

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http://link.springer.com/10.1007/s11882-019-0845-7
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http://dx.doi.org/10.1007/s11882-019-0845-7DOI Listing
February 2019
4 Reads

Multimorbidities of Pediatric Allergic Rhinitis.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):13. Epub 2019 Feb 22.

INGENIO, Immunoal.lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Purpose Of Review: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. Read More

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http://dx.doi.org/10.1007/s11882-019-0843-9DOI Listing
February 2019
2 Reads

Precision Medicine in Rhinosinusitis.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):12. Epub 2019 Feb 22.

Department of Otorhinolaryngology, University Hospital of Crete, A Building 3rd Floor, University avenue, 71110, Heraklion, Crete, Greece.

Purpose Of Review: Our scope is the presentation of research and clinical progresses in relation to precision medicine that are expected to alter our clinical practice in relation to chronic rhinosinusitis (CRS). Current knowledge on phenotypes and endotypes, biomarkers, and clinical markers for diagnosis, medical and surgical therapy, and prognosis is presented as well as the role of precision medicine in United Airway Disease and SCUAD (severe-uncontrolled chronic upper airway inflammation).

Recent Findings: Current technological progresses, mostly in relation to molecular biology and information technology, have permitted more detailed pathophysiological assessments and multidimensional approaches in airways diseases. Read More

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http://dx.doi.org/10.1007/s11882-019-0850-xDOI Listing
February 2019
1 Read

Pediatric Drug Hypersensitivity.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):11. Epub 2019 Feb 22.

Division of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

Purpose Of Review: Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management.

Recent Findings: This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β-lactam reactions. Read More

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http://dx.doi.org/10.1007/s11882-019-0841-yDOI Listing
February 2019
2 Reads

Microarray Immunodiagnostics for Aeroallergens.

Curr Allergy Asthma Rep 2019 Feb 15;19(1):10. Epub 2019 Feb 15.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Purpose Of Review: The impact of new technologies, especially multiplexed molecular allergy diagnostics based on allergen arrays, on the management of complex patients with respiratory allergies has been important.

Recent Findings: Currently, the detailed characteristics of the IgE profile of the patient, such as sensitization to genuine or cross-reacting components or the sensitization to potentially harmful allergens, allow an allergist to tailor treatment in the context of precision medicine rules. A number of relevant articles have been published in recent years on this topic, and, in this review, the new added values of allergen array-based diagnostics are reported. Read More

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http://dx.doi.org/10.1007/s11882-019-0832-zDOI Listing
February 2019
2 Reads

Sampling Devices for Indoor Allergen Exposure: Pros and Cons.

Curr Allergy Asthma Rep 2019 Feb 12;19(1). Epub 2019 Feb 12.

Departments of Population Health and Pediatrics, Dell Medical School, The University of Texas at Austin, 1701 Trinity St., Stop Z0500, Austin, TX, 78712, USA.

Purpose Of Review: To review current indoor allergen sampling devices, including devices to measure allergen in reservoir and airborne dust, and personal sampling devices, with attention to sampling rationale and major indoor allergen size and characteristics.

Recent Findings: While reservoir dust vacuuming samples and airborne dust volumetric air sampling remain popular techniques, recent literature describes sampling using furnace filters and ion-charging devices, both which help to eliminate the need for trained staff; however, variable correlation with reservoir dust and volumetric air sampling has been described. Personal sampling devices include intra-nasal samples and personal volumetric air samples. Read More

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http://dx.doi.org/10.1007/s11882-019-0833-yDOI Listing
February 2019
7 Reads

Asthma and Allergy Mobile Apps in 2018.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

The Kagen Allergy Clinic, S.C, Appleton, WI, USA.

Purpose Of Review: This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps.

Recent Findings: Primary care and specialty clinicians interested in introducing digital health apps into their practices will soon have more choices, for Apple® and major electronic medical record software companies are investing heavily in the mobile medical marketplace, guaranteeing personal health information and access to care will always be immediately available in one's digital hand. Interactive mobile asthma applications are valuable assets for patients and caregivers alike, for they offer immediate communications between patients and those responsible for providing for their needs. Read More

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http://dx.doi.org/10.1007/s11882-019-0840-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394463PMC
February 2019

Optimization of the Surgical Field in Endoscopic Sinus Surgery: an Evidence-Based Approach.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

St. Paul's Sinus Centre, Vancouver, BC, Canada.

Purpose Of Review: The advent of endoscopic sinus surgery (ESS) has enabled the development of minimally invasive surgical procedures in Rhinology. However, proficiency with ESS techniques can still be hampered by poorly controlled bleeding limiting visibility of the surgical field (VSF). This can lead to increased operating time and, more importantly, increased risk of major and minor complications. Read More

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http://link.springer.com/10.1007/s11882-019-0847-5
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http://dx.doi.org/10.1007/s11882-019-0847-5DOI Listing
February 2019
4 Reads

Primary Prevention of Food Allergy.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Purpose Of Review: The goal of this review is to present an updated summary of the various approaches to prevent childhood food allergies and report recent advances in potential prevention trials for food allergy.

Recent Findings: Several approaches related to maternal dietary supplementation as well as infant GI-based supplementation have been tried and are the subject of ongoing clinical investigation. The prevalence of food allergy appears to be increasing but several, varied approaches to prevention are being actively pursued such that an effective strategy may not be too far in the future. Read More

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http://dx.doi.org/10.1007/s11882-019-0838-6DOI Listing
February 2019
2 Reads

Next-Generation Approaches for the Treatment of Food Allergy.

Curr Allergy Asthma Rep 2019 Jan 28;19(1). Epub 2019 Jan 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, John Hopkins University School of Medicine, 600 N. Wolfe St., CMSC 1102, Baltimore, MD, 21287, USA.

Purpose Of Review: IgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance. Read More

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http://link.springer.com/10.1007/s11882-019-0839-5
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http://dx.doi.org/10.1007/s11882-019-0839-5DOI Listing
January 2019
9 Reads

Influence of the Maillard Reaction on the Allergenicity of Food Proteins and the Development of Allergic Inflammation.

Curr Allergy Asthma Rep 2019 Jan 28;19(1). Epub 2019 Jan 28.

Research Group "Molecular Allergology", Paul-Ehrlich-Institut, Langen, Germany.

Purpose Of Review: The Maillard reaction (MR) is a non-enzymatic reaction between reducing sugars and compounds with free amino groups such as proteins and takes place during thermal processing and storage of foods. This review aims to discuss potential effects of dietary MR products on the pathological mechanisms of allergic diseases.

Recent Findings: Since the MR leads to modification of proteins with various types of glycation structures, the impact of the MR on the immunogenicity and potential allergenicity of food proteins in many allergenic foods has been assessed. Read More

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http://dx.doi.org/10.1007/s11882-019-0834-xDOI Listing
January 2019
1 Read

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat.

Curr Allergy Asthma Rep 2019 Jan 23;19(1). Epub 2019 Jan 23.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Purpose Of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates.

Recent Findings: IgE antibodies have been associated with delayed allergy to red meat. Read More

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http://dx.doi.org/10.1007/s11882-019-0835-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344609PMC
January 2019
20 Reads

The Impact of Immunodeficiency on NK Cell Maturation and Function.

Curr Allergy Asthma Rep 2019 Jan 19;19(1). Epub 2019 Jan 19.

Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.

Purpose Of Review: Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy.

Recent Findings: The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodeficiency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. Read More

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http://link.springer.com/10.1007/s11882-019-0836-8
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http://dx.doi.org/10.1007/s11882-019-0836-8DOI Listing
January 2019
19 Reads

Direct to Consumer Telemedicine.

Curr Allergy Asthma Rep 2019 Jan 19;19(1). Epub 2019 Jan 19.

Emory University, Atlanta, GA, USA.

Purpose Of Review: Telemedicine uses technology to connect patients and data with providers at a distance. Direct to consumer telemedicine is a rapidly growing segment of the industry.

Recent Findings: The telehealth market has skyrocketed in recent years, making it a multi-billion dollar industry. Read More

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http://dx.doi.org/10.1007/s11882-019-0837-7DOI Listing
January 2019
3 Reads

Basophil Activation Test: Old and New Applications in Allergy.

Curr Allergy Asthma Rep 2018 Nov 15;18(12):77. Epub 2018 Nov 15.

Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Purpose Of Review: The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings: Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. Read More

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http://dx.doi.org/10.1007/s11882-018-0831-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244909PMC
November 2018
3 Reads

Social Media and Allergy.

Curr Allergy Asthma Rep 2018 Nov 14;18(12):76. Epub 2018 Nov 14.

Department of Allergy and Immunology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA.

Purpose Of Review: Social media services dominate online consumption of information and play an ever expanding role in our lives. They are not only used to connect with friends and family but also to educate and recruit colleagues and patients, and to stay up-to-date with the new developments in the field of allergy and immunology.

Recent Findings: There are known risks to social media user by health care professionals mostly related to breaches of patient confidentiality, professionalism, and privacy. Read More

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http://link.springer.com/10.1007/s11882-018-0822-6
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http://dx.doi.org/10.1007/s11882-018-0822-6DOI Listing
November 2018
13 Reads

Immune and Genetic Features of the Chromosome 22q11.2 Deletion (DiGeorge Syndrome).

Curr Allergy Asthma Rep 2018 Oct 30;18(12):75. Epub 2018 Oct 30.

Department of Pathology, Division of Genomic Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.

Purpose Of Review: This review provides an update on the progress in identifying the range of immunological dysfunction seen in DiGeorge syndrome and on more recent diagnostic and treatment approaches.

Recent Findings: Clinically, the associated thymic hypoplasia/aplasia is well known and can have profound effects on T cell function. Further, the humoral arm of the immune system can be affected, with hypogammaglobulinemia and poor vaccine-specific antibody response. Read More

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http://dx.doi.org/10.1007/s11882-018-0823-5DOI Listing
October 2018
5 Reads

Innovation in Food Challenge Tests for Food Allergy.

Curr Allergy Asthma Rep 2018 Oct 30;18(12):74. Epub 2018 Oct 30.

Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1198, New York, NY, 10029, USA.

Purpose Of Review: This review incorporates findings from studies of oral food challenges (OFC) over the last decade and highlights the latest innovations and understanding of the procedure.

Recent Findings: PRACTALL guidelines are widely used in OFC research, but there is still no international consensus on the OFC protocol in clinical practice. Guidelines for performing OFC in clinical practice have been updated to include oral food challenges for infants. Read More

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http://link.springer.com/10.1007/s11882-018-0825-3
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http://dx.doi.org/10.1007/s11882-018-0825-3DOI Listing
October 2018
3 Reads

Defining Pollen Seasons: Background and Recommendations.

Curr Allergy Asthma Rep 2018 Oct 29;18(12):73. Epub 2018 Oct 29.

Research group Aerobiology and pollen information, Department of Oto-Rhino-Laryngology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Wien, Austria.

Purpose Of Review: The definition of a pollen season determines the start and the end of the time period with a certain amount of pollen in the ambient air. Different pollen season definitions were used for a long time including the use of different terms for data and methods used to define a pollen season. Recently suggested pollen season definitions for clinical trials were tested and applied for the first time to more aeroallergens. Read More

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http://dx.doi.org/10.1007/s11882-018-0829-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209030PMC
October 2018
1 Read

Exercise-Induced Anaphylaxis: Literature Review and Recent Updates.

Curr Allergy Asthma Rep 2018 Oct 26;18(12):72. Epub 2018 Oct 26.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 60 Fenwood Rd., Building for Transformative Medicine, 5th Floor, Boston, MA, 02115, USA.

Purpose Of Review: This paper will review the pathophysiology, diagnosis, and treatment of exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis with an emphasis on novel studies published in the past several years.

Recent Findings: Exercise-induced anaphylaxis (EIAn) is a clinical syndrome characterized by anaphylaxis during or shortly after physical exertion. The syndrome is broadly grouped into two categories: exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis (FDEIAn). Read More

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http://link.springer.com/10.1007/s11882-018-0830-6
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http://dx.doi.org/10.1007/s11882-018-0830-6DOI Listing
October 2018
17 Reads

Virus-Like Particles as Carrier Systems to Enhance Immunomodulation in Allergen Immunotherapy.

Curr Allergy Asthma Rep 2018 Oct 25;18(12):71. Epub 2018 Oct 25.

Section Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich Str. 51-59, D-63225, Langen, Germany.

Purpose Of Review: Utilization of virus-like particles (VLPs) is considered to improve allergen-specific immunotherapy (AIT). AIT aims at the efficient uptake of the target allergen by antigen-presenting cells (APCs) subsequently inducing adaptive allergen-specific immune responses to induce tolerance. The purpose of this review is to describe the immune-modulating properties of VLPs per se and to summarize the application of VLPs as antigen carriers, preferably for Th2 cytokines or allergens, with and without simultaneous administration of adjuvants in order to modulate allergic immune responses. Read More

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http://link.springer.com/10.1007/s11882-018-0827-1
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http://dx.doi.org/10.1007/s11882-018-0827-1DOI Listing
October 2018
17 Reads

Letter to the Authors Concerning the Published Manuscript by Rial and Sastre: Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is Behind the Geographic Restriction?

Curr Allergy Asthma Rep 2018 Oct 25;18(12):70. Epub 2018 Oct 25.

Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s11882-018-0828-0DOI Listing
October 2018
4 Reads

How the Smartphone Is Changing Allergy Diagnostics.

Curr Allergy Asthma Rep 2018 Oct 25;18(12):69. Epub 2018 Oct 25.

Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.

Purpose Of Review: Evidence-based clinical diagnosis of allergic disorders is increasingly challenging. Clinical decision support systems implemented in mobile applications (apps) are being developed to assist clinicians in diagnostic decisions at the point of care. We reviewed apps for allergic diseases general diagnosis, diagnostic refinement and diagnostic personalisation. Read More

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http://link.springer.com/10.1007/s11882-018-0824-4
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http://dx.doi.org/10.1007/s11882-018-0824-4DOI Listing
October 2018
31 Reads

The Influence of Age on the Relationship Between Allergic Rhinitis and Otitis Media.

Curr Allergy Asthma Rep 2018 Oct 20;18(12):68. Epub 2018 Oct 20.

Department of Otolaryngology, Harvard Medical School, 45 Francis Street, Boston, MA, 02115, USA.

Purpose Of Review: To examine the relationship between otitis media, allergic rhinitis, and age.

Recent Findings: Otitis media and allergic rhinitis are prevalent conditions with a controversial relationship. Some data suggest that these entities are significantly associated, either through allergic rhinitis inducing Eustachian tube dysfunction or through allergic pathophysiology simultaneously occurring intranasally and in the ear. Read More

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http://link.springer.com/10.1007/s11882-018-0826-2
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http://dx.doi.org/10.1007/s11882-018-0826-2DOI Listing
October 2018
14 Reads

IgE Test in Secretions of Patients with Respiratory Allergy.

Curr Allergy Asthma Rep 2018 Oct 13;18(12):67. Epub 2018 Oct 13.

Allergy Unit, IBIMA-Regional University Hospital of Málaga, Málaga, Spain.

Purpose Of Review: IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP).

Recent Findings: Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Read More

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http://dx.doi.org/10.1007/s11882-018-0821-7DOI Listing
October 2018
3 Reads

The Multifaceted B Cell Response in Allergen Immunotherapy.

Curr Allergy Asthma Rep 2018 Oct 5;18(12):66. Epub 2018 Oct 5.

Department of Medicine Division of Rheumatology, Allergy, and Immunology, Department of Pediatrics, Division of Allergy and Immunology, Food Allergy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

While allergen immunotherapy (AIT) for IgE-mediated diseases holds curative potential, the considerable heterogeneity in clinical outcomes may relate to the complex mechanisms of tolerance. The regulation of humoral immunity by AIT contributes to the suppression of allergic responses. Recent findings have revealed novel roles for IgA and IgG antibodies in the induction of tolerance. Read More

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http://link.springer.com/10.1007/s11882-018-0819-1
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http://dx.doi.org/10.1007/s11882-018-0819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277970PMC
October 2018
2 Reads

Agriculture Occupational Exposures and Factors Affecting Health Effects.

Curr Allergy Asthma Rep 2018 Oct 5;18(12):65. Epub 2018 Oct 5.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Purpose Of Review: Agriculture environments contain a variety of inflammatory aerosols that may increase risk for lung inflammation and disease in exposed individuals. In addition, epidemiological studies have also identified protective effects of rural environments and farming exposures.

Recent Findings: In this review, we will discuss recent literature published since 2016 that investigates the impact of differing agricultural exposures on respiratory health. Read More

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http://link.springer.com/10.1007/s11882-018-0820-8
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http://dx.doi.org/10.1007/s11882-018-0820-8DOI Listing
October 2018
3 Reads

Biomarkers in Food Allergy.

Curr Allergy Asthma Rep 2018 Oct 3;18(11):64. Epub 2018 Oct 3.

Allergy Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Purpose Of Review: To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.

Recent Findings: Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. Read More

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http://link.springer.com/10.1007/s11882-018-0816-4
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http://dx.doi.org/10.1007/s11882-018-0816-4DOI Listing
October 2018
22 Reads

Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation.

Authors:
Seema Patel

Curr Allergy Asthma Rep 2018 Sep 28;18(11):63. Epub 2018 Sep 28.

Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA, 92182, USA.

Purpose Of Review: Allergen is an umbrella term for irritants of diverse origin. Along with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens can be grouped as inflammatory agents. Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm signals by the innate immune system. Read More

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http://dx.doi.org/10.1007/s11882-018-0817-3DOI Listing
September 2018
5 Reads

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment.

Curr Allergy Asthma Rep 2018 Sep 26;18(11):61. Epub 2018 Sep 26.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Purpose Of Review: Allergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies. Read More

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http://link.springer.com/10.1007/s11882-018-0815-5
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http://dx.doi.org/10.1007/s11882-018-0815-5DOI Listing
September 2018
19 Reads

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects.

Curr Allergy Asthma Rep 2018 Sep 26;18(11):60. Epub 2018 Sep 26.

Visio Health and Technical Solutions, Inc., Omaha, NE, USA.

Purpose Of Review: Telemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program. Read More

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http://dx.doi.org/10.1007/s11882-018-0814-6DOI Listing
September 2018
15 Reads

Emerging Insights into the Occupational Mycobiome.

Authors:
Brett J Green

Curr Allergy Asthma Rep 2018 Sep 27;18(11):62. Epub 2018 Sep 27.

Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, 26505, USA.

Purpose Of Review: The evolution of molecular-based methods over the last two decades has provided new approaches to identify and characterize fungal communities or "mycobiomes" at resolutions previously not possible using traditional hazard identification methods. The recent focus on fungal community assemblages within indoor environments has provided renewed insight into overlooked sources of fungal exposure. In occupational studies, internal transcribed spacer (ITS) region sequencing has recently been utilized in a variety of environments ranging from indoor office buildings to agricultural commodity and harvesting operations. Read More

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http://dx.doi.org/10.1007/s11882-018-0818-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441957PMC
September 2018
2 Reads

Impact of Climate Change on Pollen and Respiratory Disease.

Authors:
Charles S Barnes

Curr Allergy Asthma Rep 2018 Sep 20;18(11):59. Epub 2018 Sep 20.

Division of Allergy, Asthma and Immunology, Children's Mercy Hospital, The University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. Read More

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http://dx.doi.org/10.1007/s11882-018-0813-7DOI Listing
September 2018
3 Reads

Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought.

Curr Allergy Asthma Rep 2018 Sep 18;18(11):58. Epub 2018 Sep 18.

Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY, 10029, USA.

Purpose Of Review: The development of allergic disease is shaped by genetics and the environment, including diet. Many studies suggest a role for maternal diet during pregnancy. In this article, we discuss potential mechanisms by which specific nutrients, particular foods, and dietary patterns may influence allergic disease development and review studies examining the relationship between prenatal diet and the risk of childhood allergy. Read More

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http://dx.doi.org/10.1007/s11882-018-0811-9DOI Listing
September 2018
9 Reads

Administering a Telemedicine Program.

Curr Allergy Asthma Rep 2018 Sep 15;18(11):57. Epub 2018 Sep 15.

Department of Medical Informatics and Telemedicine, Children's Mercy, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: The purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine program.

Recent Findings: Recent literature findings suggest that telemedicine in specialty clinics continues to grow at a rapid pace. Medical specialty programs should prepare to adopt a practice that includes telemedicine to better serve their patients and families who have expressed significant satisfaction with the delivery of healthcare in this manner. Read More

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http://dx.doi.org/10.1007/s11882-018-0812-8DOI Listing
September 2018
3 Reads