1,355 results match your criteria Current Allergy and Asthma Reports[Journal]


Microarray Immunodiagnostics for Aeroallergens.

Curr Allergy Asthma Rep 2019 Feb 15;19(1):10. Epub 2019 Feb 15.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Purpose Of Review: The impact of new technologies, especially multiplexed molecular allergy diagnostics based on allergen arrays, on the management of complex patients with respiratory allergies has been important.

Recent Findings: Currently, the detailed characteristics of the IgE profile of the patient, such as sensitization to genuine or cross-reacting components or the sensitization to potentially harmful allergens, allow an allergist to tailor treatment in the context of precision medicine rules. A number of relevant articles have been published in recent years on this topic, and, in this review, the new added values of allergen array-based diagnostics are reported. Read More

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http://dx.doi.org/10.1007/s11882-019-0832-zDOI Listing
February 2019

Sampling Devices for Indoor Allergen Exposure: Pros and Cons.

Curr Allergy Asthma Rep 2019 Feb 12;19(1). Epub 2019 Feb 12.

Departments of Population Health and Pediatrics, Dell Medical School, The University of Texas at Austin, 1701 Trinity St., Stop Z0500, Austin, TX, 78712, USA.

Purpose Of Review: To review current indoor allergen sampling devices, including devices to measure allergen in reservoir and airborne dust, and personal sampling devices, with attention to sampling rationale and major indoor allergen size and characteristics.

Recent Findings: While reservoir dust vacuuming samples and airborne dust volumetric air sampling remain popular techniques, recent literature describes sampling using furnace filters and ion-charging devices, both which help to eliminate the need for trained staff; however, variable correlation with reservoir dust and volumetric air sampling has been described. Personal sampling devices include intra-nasal samples and personal volumetric air samples. Read More

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http://dx.doi.org/10.1007/s11882-019-0833-yDOI Listing
February 2019
2 Reads

Asthma and Allergy Mobile Apps in 2018.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

The Kagen Allergy Clinic, S.C, Appleton, WI, USA.

Purpose Of Review: This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps.

Recent Findings: Primary care and specialty clinicians interested in introducing digital health apps into their practices will soon have more choices, for Apple® and major electronic medical record software companies are investing heavily in the mobile medical marketplace, guaranteeing personal health information and access to care will always be immediately available in one's digital hand. Interactive mobile asthma applications are valuable assets for patients and caregivers alike, for they offer immediate communications between patients and those responsible for providing for their needs. Read More

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http://dx.doi.org/10.1007/s11882-019-0840-zDOI Listing
February 2019

Optimization of the Surgical Field in Endoscopic Sinus Surgery: an Evidence-Based Approach.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

St. Paul's Sinus Centre, Vancouver, BC, Canada.

Purpose Of Review: The advent of endoscopic sinus surgery (ESS) has enabled the development of minimally invasive surgical procedures in Rhinology. However, proficiency with ESS techniques can still be hampered by poorly controlled bleeding limiting visibility of the surgical field (VSF). This can lead to increased operating time and, more importantly, increased risk of major and minor complications. Read More

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http://dx.doi.org/10.1007/s11882-019-0847-5DOI Listing
February 2019

Primary Prevention of Food Allergy.

Curr Allergy Asthma Rep 2019 Feb 2;19(1). Epub 2019 Feb 2.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Purpose Of Review: The goal of this review is to present an updated summary of the various approaches to prevent childhood food allergies and report recent advances in potential prevention trials for food allergy.

Recent Findings: Several approaches related to maternal dietary supplementation as well as infant GI-based supplementation have been tried and are the subject of ongoing clinical investigation. The prevalence of food allergy appears to be increasing but several, varied approaches to prevention are being actively pursued such that an effective strategy may not be too far in the future. Read More

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http://dx.doi.org/10.1007/s11882-019-0838-6DOI Listing
February 2019
2 Reads

Next-Generation Approaches for the Treatment of Food Allergy.

Curr Allergy Asthma Rep 2019 Jan 28;19(1). Epub 2019 Jan 28.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, John Hopkins University School of Medicine, 600 N. Wolfe St., CMSC 1102, Baltimore, MD, 21287, USA.

Purpose Of Review: IgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance. Read More

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http://link.springer.com/10.1007/s11882-019-0839-5
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http://dx.doi.org/10.1007/s11882-019-0839-5DOI Listing
January 2019
4 Reads

Influence of the Maillard Reaction on the Allergenicity of Food Proteins and the Development of Allergic Inflammation.

Curr Allergy Asthma Rep 2019 Jan 28;19(1). Epub 2019 Jan 28.

Research Group "Molecular Allergology", Paul-Ehrlich-Institut, Langen, Germany.

Purpose Of Review: The Maillard reaction (MR) is a non-enzymatic reaction between reducing sugars and compounds with free amino groups such as proteins and takes place during thermal processing and storage of foods. This review aims to discuss potential effects of dietary MR products on the pathological mechanisms of allergic diseases.

Recent Findings: Since the MR leads to modification of proteins with various types of glycation structures, the impact of the MR on the immunogenicity and potential allergenicity of food proteins in many allergenic foods has been assessed. Read More

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http://dx.doi.org/10.1007/s11882-019-0834-xDOI Listing
January 2019

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat.

Curr Allergy Asthma Rep 2019 Jan 23;19(1). Epub 2019 Jan 23.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Purpose Of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates.

Recent Findings: IgE antibodies have been associated with delayed allergy to red meat. Read More

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http://dx.doi.org/10.1007/s11882-019-0835-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344609PMC
January 2019
6 Reads

The Impact of Immunodeficiency on NK Cell Maturation and Function.

Curr Allergy Asthma Rep 2019 Jan 19;19(1). Epub 2019 Jan 19.

Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.

Purpose Of Review: Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy.

Recent Findings: The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodeficiency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. Read More

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http://link.springer.com/10.1007/s11882-019-0836-8
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http://dx.doi.org/10.1007/s11882-019-0836-8DOI Listing
January 2019
6 Reads

Direct to Consumer Telemedicine.

Curr Allergy Asthma Rep 2019 Jan 19;19(1). Epub 2019 Jan 19.

Emory University, Atlanta, GA, USA.

Purpose Of Review: Telemedicine uses technology to connect patients and data with providers at a distance. Direct to consumer telemedicine is a rapidly growing segment of the industry.

Recent Findings: The telehealth market has skyrocketed in recent years, making it a multi-billion dollar industry. Read More

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http://dx.doi.org/10.1007/s11882-019-0837-7DOI Listing
January 2019
1 Read

Basophil Activation Test: Old and New Applications in Allergy.

Curr Allergy Asthma Rep 2018 Nov 15;18(12):77. Epub 2018 Nov 15.

Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Purpose Of Review: The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings: Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. Read More

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http://dx.doi.org/10.1007/s11882-018-0831-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244909PMC
November 2018
3 Reads

Social Media and Allergy.

Curr Allergy Asthma Rep 2018 Nov 14;18(12):76. Epub 2018 Nov 14.

Department of Allergy and Immunology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA.

Purpose Of Review: Social media services dominate online consumption of information and play an ever expanding role in our lives. They are not only used to connect with friends and family but also to educate and recruit colleagues and patients, and to stay up-to-date with the new developments in the field of allergy and immunology.

Recent Findings: There are known risks to social media user by health care professionals mostly related to breaches of patient confidentiality, professionalism, and privacy. Read More

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http://link.springer.com/10.1007/s11882-018-0822-6
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http://dx.doi.org/10.1007/s11882-018-0822-6DOI Listing
November 2018
11 Reads

Immune and Genetic Features of the Chromosome 22q11.2 Deletion (DiGeorge Syndrome).

Curr Allergy Asthma Rep 2018 Oct 30;18(12):75. Epub 2018 Oct 30.

Department of Pathology, Division of Genomic Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.

Purpose Of Review: This review provides an update on the progress in identifying the range of immunological dysfunction seen in DiGeorge syndrome and on more recent diagnostic and treatment approaches.

Recent Findings: Clinically, the associated thymic hypoplasia/aplasia is well known and can have profound effects on T cell function. Further, the humoral arm of the immune system can be affected, with hypogammaglobulinemia and poor vaccine-specific antibody response. Read More

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http://dx.doi.org/10.1007/s11882-018-0823-5DOI Listing
October 2018
4 Reads

Innovation in Food Challenge Tests for Food Allergy.

Curr Allergy Asthma Rep 2018 Oct 30;18(12):74. Epub 2018 Oct 30.

Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1198, New York, NY, 10029, USA.

Purpose Of Review: This review incorporates findings from studies of oral food challenges (OFC) over the last decade and highlights the latest innovations and understanding of the procedure.

Recent Findings: PRACTALL guidelines are widely used in OFC research, but there is still no international consensus on the OFC protocol in clinical practice. Guidelines for performing OFC in clinical practice have been updated to include oral food challenges for infants. Read More

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http://link.springer.com/10.1007/s11882-018-0825-3
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http://dx.doi.org/10.1007/s11882-018-0825-3DOI Listing
October 2018
3 Reads

Defining Pollen Seasons: Background and Recommendations.

Curr Allergy Asthma Rep 2018 Oct 29;18(12):73. Epub 2018 Oct 29.

Research group Aerobiology and pollen information, Department of Oto-Rhino-Laryngology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Wien, Austria.

Purpose Of Review: The definition of a pollen season determines the start and the end of the time period with a certain amount of pollen in the ambient air. Different pollen season definitions were used for a long time including the use of different terms for data and methods used to define a pollen season. Recently suggested pollen season definitions for clinical trials were tested and applied for the first time to more aeroallergens. Read More

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http://dx.doi.org/10.1007/s11882-018-0829-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209030PMC
October 2018
1 Read

Exercise-Induced Anaphylaxis: Literature Review and Recent Updates.

Curr Allergy Asthma Rep 2018 Oct 26;18(12):72. Epub 2018 Oct 26.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 60 Fenwood Rd., Building for Transformative Medicine, 5th Floor, Boston, MA, 02115, USA.

Purpose Of Review: This paper will review the pathophysiology, diagnosis, and treatment of exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis with an emphasis on novel studies published in the past several years.

Recent Findings: Exercise-induced anaphylaxis (EIAn) is a clinical syndrome characterized by anaphylaxis during or shortly after physical exertion. The syndrome is broadly grouped into two categories: exercise-induced anaphylaxis and food-dependent, exercise-induced anaphylaxis (FDEIAn). Read More

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http://link.springer.com/10.1007/s11882-018-0830-6
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http://dx.doi.org/10.1007/s11882-018-0830-6DOI Listing
October 2018
12 Reads

Virus-Like Particles as Carrier Systems to Enhance Immunomodulation in Allergen Immunotherapy.

Curr Allergy Asthma Rep 2018 Oct 25;18(12):71. Epub 2018 Oct 25.

Section Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich Str. 51-59, D-63225, Langen, Germany.

Purpose Of Review: Utilization of virus-like particles (VLPs) is considered to improve allergen-specific immunotherapy (AIT). AIT aims at the efficient uptake of the target allergen by antigen-presenting cells (APCs) subsequently inducing adaptive allergen-specific immune responses to induce tolerance. The purpose of this review is to describe the immune-modulating properties of VLPs per se and to summarize the application of VLPs as antigen carriers, preferably for Th2 cytokines or allergens, with and without simultaneous administration of adjuvants in order to modulate allergic immune responses. Read More

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http://link.springer.com/10.1007/s11882-018-0827-1
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http://dx.doi.org/10.1007/s11882-018-0827-1DOI Listing
October 2018
12 Reads

Letter to the Authors Concerning the Published Manuscript by Rial and Sastre: Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is Behind the Geographic Restriction?

Curr Allergy Asthma Rep 2018 Oct 25;18(12):70. Epub 2018 Oct 25.

Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s11882-018-0828-0DOI Listing
October 2018
3 Reads

How the Smartphone Is Changing Allergy Diagnostics.

Curr Allergy Asthma Rep 2018 Oct 25;18(12):69. Epub 2018 Oct 25.

Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.

Purpose Of Review: Evidence-based clinical diagnosis of allergic disorders is increasingly challenging. Clinical decision support systems implemented in mobile applications (apps) are being developed to assist clinicians in diagnostic decisions at the point of care. We reviewed apps for allergic diseases general diagnosis, diagnostic refinement and diagnostic personalisation. Read More

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http://link.springer.com/10.1007/s11882-018-0824-4
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http://dx.doi.org/10.1007/s11882-018-0824-4DOI Listing
October 2018
21 Reads

The Influence of Age on the Relationship Between Allergic Rhinitis and Otitis Media.

Curr Allergy Asthma Rep 2018 Oct 20;18(12):68. Epub 2018 Oct 20.

Department of Otolaryngology, Harvard Medical School, 45 Francis Street, Boston, MA, 02115, USA.

Purpose Of Review: To examine the relationship between otitis media, allergic rhinitis, and age.

Recent Findings: Otitis media and allergic rhinitis are prevalent conditions with a controversial relationship. Some data suggest that these entities are significantly associated, either through allergic rhinitis inducing Eustachian tube dysfunction or through allergic pathophysiology simultaneously occurring intranasally and in the ear. Read More

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http://link.springer.com/10.1007/s11882-018-0826-2
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http://dx.doi.org/10.1007/s11882-018-0826-2DOI Listing
October 2018
10 Reads

IgE Test in Secretions of Patients with Respiratory Allergy.

Curr Allergy Asthma Rep 2018 Oct 13;18(12):67. Epub 2018 Oct 13.

Allergy Unit, IBIMA-Regional University Hospital of Málaga, Málaga, Spain.

Purpose Of Review: IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP).

Recent Findings: Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Read More

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http://dx.doi.org/10.1007/s11882-018-0821-7DOI Listing
October 2018
2 Reads

The Multifaceted B Cell Response in Allergen Immunotherapy.

Curr Allergy Asthma Rep 2018 Oct 5;18(12):66. Epub 2018 Oct 5.

Department of Medicine Division of Rheumatology, Allergy, and Immunology, Department of Pediatrics, Division of Allergy and Immunology, Food Allergy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

While allergen immunotherapy (AIT) for IgE-mediated diseases holds curative potential, the considerable heterogeneity in clinical outcomes may relate to the complex mechanisms of tolerance. The regulation of humoral immunity by AIT contributes to the suppression of allergic responses. Recent findings have revealed novel roles for IgA and IgG antibodies in the induction of tolerance. Read More

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http://link.springer.com/10.1007/s11882-018-0819-1
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http://dx.doi.org/10.1007/s11882-018-0819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277970PMC
October 2018
2 Reads

Agriculture Occupational Exposures and Factors Affecting Health Effects.

Curr Allergy Asthma Rep 2018 Oct 5;18(12):65. Epub 2018 Oct 5.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Purpose Of Review: Agriculture environments contain a variety of inflammatory aerosols that may increase risk for lung inflammation and disease in exposed individuals. In addition, epidemiological studies have also identified protective effects of rural environments and farming exposures.

Recent Findings: In this review, we will discuss recent literature published since 2016 that investigates the impact of differing agricultural exposures on respiratory health. Read More

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http://link.springer.com/10.1007/s11882-018-0820-8
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http://dx.doi.org/10.1007/s11882-018-0820-8DOI Listing
October 2018
3 Reads

Biomarkers in Food Allergy.

Curr Allergy Asthma Rep 2018 Oct 3;18(11):64. Epub 2018 Oct 3.

Allergy Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Purpose Of Review: To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.

Recent Findings: Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. Read More

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http://link.springer.com/10.1007/s11882-018-0816-4
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http://dx.doi.org/10.1007/s11882-018-0816-4DOI Listing
October 2018
14 Reads

Danger-Associated Molecular Patterns (DAMPs): the Derivatives and Triggers of Inflammation.

Authors:
Seema Patel

Curr Allergy Asthma Rep 2018 Sep 28;18(11):63. Epub 2018 Sep 28.

Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA, 92182, USA.

Purpose Of Review: Allergen is an umbrella term for irritants of diverse origin. Along with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens can be grouped as inflammatory agents. Danger-associated molecular patterns (DAMPs) are altered metabolism products of necrotic or stressed cells, which are deemed as alarm signals by the innate immune system. Read More

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http://dx.doi.org/10.1007/s11882-018-0817-3DOI Listing
September 2018
5 Reads

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment.

Curr Allergy Asthma Rep 2018 Sep 26;18(11):61. Epub 2018 Sep 26.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Purpose Of Review: Allergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies. Read More

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http://link.springer.com/10.1007/s11882-018-0815-5
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http://dx.doi.org/10.1007/s11882-018-0815-5DOI Listing
September 2018
14 Reads

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects.

Curr Allergy Asthma Rep 2018 Sep 26;18(11):60. Epub 2018 Sep 26.

Visio Health and Technical Solutions, Inc., Omaha, NE, USA.

Purpose Of Review: Telemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program. Read More

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http://dx.doi.org/10.1007/s11882-018-0814-6DOI Listing
September 2018
15 Reads

Emerging Insights into the Occupational Mycobiome.

Authors:
Brett J Green

Curr Allergy Asthma Rep 2018 Sep 27;18(11):62. Epub 2018 Sep 27.

Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, 26505, USA.

Purpose Of Review: The evolution of molecular-based methods over the last two decades has provided new approaches to identify and characterize fungal communities or "mycobiomes" at resolutions previously not possible using traditional hazard identification methods. The recent focus on fungal community assemblages within indoor environments has provided renewed insight into overlooked sources of fungal exposure. In occupational studies, internal transcribed spacer (ITS) region sequencing has recently been utilized in a variety of environments ranging from indoor office buildings to agricultural commodity and harvesting operations. Read More

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http://dx.doi.org/10.1007/s11882-018-0818-2DOI Listing
September 2018
2 Reads

Impact of Climate Change on Pollen and Respiratory Disease.

Authors:
Charles S Barnes

Curr Allergy Asthma Rep 2018 Sep 20;18(11):59. Epub 2018 Sep 20.

Division of Allergy, Asthma and Immunology, Children's Mercy Hospital, The University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. Read More

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http://dx.doi.org/10.1007/s11882-018-0813-7DOI Listing
September 2018
3 Reads

Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought.

Curr Allergy Asthma Rep 2018 Sep 18;18(11):58. Epub 2018 Sep 18.

Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY, 10029, USA.

Purpose Of Review: The development of allergic disease is shaped by genetics and the environment, including diet. Many studies suggest a role for maternal diet during pregnancy. In this article, we discuss potential mechanisms by which specific nutrients, particular foods, and dietary patterns may influence allergic disease development and review studies examining the relationship between prenatal diet and the risk of childhood allergy. Read More

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http://dx.doi.org/10.1007/s11882-018-0811-9DOI Listing
September 2018
4 Reads

Administering a Telemedicine Program.

Curr Allergy Asthma Rep 2018 Sep 15;18(11):57. Epub 2018 Sep 15.

Department of Medical Informatics and Telemedicine, Children's Mercy, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: The purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine program.

Recent Findings: Recent literature findings suggest that telemedicine in specialty clinics continues to grow at a rapid pace. Medical specialty programs should prepare to adopt a practice that includes telemedicine to better serve their patients and families who have expressed significant satisfaction with the delivery of healthcare in this manner. Read More

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http://dx.doi.org/10.1007/s11882-018-0812-8DOI Listing
September 2018
3 Reads

Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is behind the Geographic Restriction?

Authors:
M J Rial J Sastre

Curr Allergy Asthma Rep 2018 Sep 11;18(11):56. Epub 2018 Sep 11.

Allergy Department, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Av. de los Reyes Católicos, 2, 28040, Madrid, Spain.

Purpose Of Review: To critically examine evidence suggesting that food allergy induced by lipid transfer proteins (LTPs) follows a geographic pattern.

Recent Findings: LTP syndrome remains most common in the Mediterranean basin, with a clear gradient seen in prevalence of LTP sensitization between northern and southern Europe. We hypothesize that high levels of birch pollen seem to protect against LTP allergy, as these higher levels correlate with a lower prevalence of LTP hypersensitivity. Read More

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http://dx.doi.org/10.1007/s11882-018-0810-xDOI Listing
September 2018
1 Read

Biologics and Small Molecule Agents in Allergic and Immunologic Skin Diseases.

Curr Allergy Asthma Rep 2018 Aug 31;18(10):55. Epub 2018 Aug 31.

Mount Sinai St. Luke's and West, 1090 Amsterdam Avenue, Suite 11B, New York, NY, 10029, USA.

Purpose Of Review: Biologics and small molecules are key therapeutic options in the treatment of chronic immunologic and allergic skin conditions. By directly targeting innate and inflammatory responses within the skin, including pro-inflammatory cytokines and cellular signaling pathways, these new agents have the potential to counteract the inflammatory cascade responsible for various conditions, including psoriasis and atopic dermatitis. Over the past decade, groundbreaking research identifying key cytokines and receptors involved in the pathogenesis of these diseases has allowed for the development of highly efficacious biologics and small molecules that are associated with unprecedented rates of skin clearance and favorable adverse event profiles. Read More

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http://link.springer.com/10.1007/s11882-018-0804-8
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http://dx.doi.org/10.1007/s11882-018-0804-8DOI Listing
August 2018
21 Reads

Telemedicine: a Primer.

Curr Allergy Asthma Rep 2018 Aug 25;18(10):54. Epub 2018 Aug 25.

Department of Medical Informatics and Telemedicine, Children's Mercy, Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: Due to rapid advancements in quality of real-time, interactive, audio-visual, and digital technologies as well as impressive gains in internet speed and capacity, medicine delivered over distance is happening faster than many healthcare providers and leaders can grasp.

Recent Findings: Depending on which market report you ascribe to, industry projections for the global compounded annual growth rate of telemedicine are between 13 and 27%, with valuation growing to over 20 billion US dollars in the next several years. The Mayo Clinic has reworked its entire telemedicine interest to a model with centralized operations, one virtual technology platform, standardized training, and connectedness for all of its locations. Read More

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http://dx.doi.org/10.1007/s11882-018-0808-4DOI Listing
August 2018
4 Reads

A Review of Portable Electronic Spirometers: Implications for Asthma Self-Management.

Curr Allergy Asthma Rep 2018 Aug 25;18(10):53. Epub 2018 Aug 25.

Department of Practice and Policy, Centre for Behavioural Medicine, UCL School of Pharmacy, Mezzanine Floor, Entrance A, Tavistock House North, Tavistock Square, London, WC1H 9HR, UK.

Purpose Of Review: Although portable electronic spirometers allow for at-home lung function monitoring, a comprehensive review of these devices has not yet been conducted. We conducted a systematic search and review of commercially available portable electronic spirometers designed for asthma patient use.

Recent Findings: All devices (N = 16) allowed for monitoring of basic lung function parameters, but only 31% provided in-app videos on how to perform breathing maneuvers. Read More

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http://link.springer.com/10.1007/s11882-018-0809-3
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http://dx.doi.org/10.1007/s11882-018-0809-3DOI Listing
August 2018
20 Reads

Bedroom Allergen Exposure Beyond House Dust Mites.

Curr Allergy Asthma Rep 2018 Aug 20;18(10):52. Epub 2018 Aug 20.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, North Carolina, 27709, USA.

Purpose Of Review: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest, and fungal exposures.

Recent Findings: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, have extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Read More

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http://dx.doi.org/10.1007/s11882-018-0805-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222253PMC
August 2018
3 Reads

Clinical Manifestation of Hyper IgE Syndrome Including Otitis Media.

Curr Allergy Asthma Rep 2018 Aug 15;18(10):51. Epub 2018 Aug 15.

Department of Allergy and Immunology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, 200127, China.

Purpose Of Review: The hyper IgE syndromes (HIES) comprise a group of rare primary immunodeficiency disorders (PIDDs), which are characterized by extremely high serum IgE levels, eczema, recurrent skin and pulmonary infections. Both autosomal dominant (AD) HIES due to STAT3 mutations and autosomal recessive (AR) HIES due to PGM3, SPINK5, DOCK8 and TKY2 mutations have been reported. Here, we aim to summarize and compare the major clinical manifestations of different subtypes of HIES. Read More

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http://link.springer.com/10.1007/s11882-018-0806-6
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http://dx.doi.org/10.1007/s11882-018-0806-6DOI Listing
August 2018
20 Reads
2.770 Impact Factor

Tips for Seeing Patients via Telemedicine.

Curr Allergy Asthma Rep 2018 Aug 15;18(10):50. Epub 2018 Aug 15.

Children's Mercy, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Purpose Of Review: Telemedicine is a technology that permits patients to be seen at a distance. This review describes different types of telemedicine, why they might be useful for a practice, what equipment is needed, and how to select and schedule patients.

Recent Findings: The use of synchronous telemedicine is increasing rapidly and has surpassed 50% of ambulatory encounters in some instances. Read More

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http://dx.doi.org/10.1007/s11882-018-0807-5DOI Listing
August 2018
2 Reads

Allergic Contact Dermatitis Evaluation: Strategies for the Preschooler.

Curr Allergy Asthma Rep 2018 Aug 1;18(10):49. Epub 2018 Aug 1.

Department of Dermatology, Loma Linda University, 11370 Anderson Street, Suite 2600, Loma Linda, CA, 92354, USA.

Purpose Of Review: The environment for the developing children is complex as they are exposed to a variety of activities and settings where potential environmental allergens may be encountered. Recent evidence supports the clinical benefit of patch testing young children suffering from recalcitrant dermatitis. While patch testing has been recently approved by the Food and Drug Administration in children ages 6-18 years old, patch testing strategies for young children of preschool age (between 2 and 6 years old) have yet to be defined. Read More

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http://dx.doi.org/10.1007/s11882-018-0803-9DOI Listing
August 2018
4 Reads

Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions.

Curr Allergy Asthma Rep 2018 Jul 26;18(9):48. Epub 2018 Jul 26.

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.

Purpose Of Review: Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). Read More

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http://dx.doi.org/10.1007/s11882-018-0802-xDOI Listing
July 2018
2 Reads

Endotypes of Chronic Rhinosinusitis Across Ancestry and Geographic Regions.

Curr Allergy Asthma Rep 2018 Jul 11;18(9):46. Epub 2018 Jul 11.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Prathumwan, Bangkok, 10330, Thailand.

Purpose Of Review: Preliminary studies have suggested differences in endotypes of chronic rhinosinusitis (CRS) across ancestry/ethnic groups. Eosinophilic CRS (ECRS) is the predominant subtype for Western/European ancestry CRS patients and non-eosinophilic CRS (nECRS) for Asian patients. This review aims to re-analyze CRS endotypes across ancestry populations using one consistent criteria to existing data. Read More

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http://dx.doi.org/10.1007/s11882-018-0800-zDOI Listing
July 2018
28 Reads
2.770 Impact Factor

Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence.

Curr Allergy Asthma Rep 2018 Jul 11;18(9):47. Epub 2018 Jul 11.

Division of Allergy, Immunology and Transplantation, Allergy, Asthma and Airway Biology Branch, National Institute of Allergy and Infectious Diseases, NIH, 5601 Fishers Lane, Rockville, MD, 20892, USA.

Purpose Of Review: Although evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions.

Recent Findings: In aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation. Read More

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http://dx.doi.org/10.1007/s11882-018-0801-yDOI Listing
July 2018
3 Reads

Prospects for Monoclonal Antibody Therapy in Pediatric Asthma.

Curr Allergy Asthma Rep 2018 Jul 10;18(9):45. Epub 2018 Jul 10.

Rutgers New Jersey Medical School, The State University of New Jersey, 90 Bergen Street, Newark, NJ, 07103, USA.

Purpose Of Review: The profile of biologic therapies for asthma is growing rapidly. We discuss how to match the proper pediatric patient with the most effective therapy.

Recent Findings: Currently available biologic therapies are most effective in patients with T2 high asthma. Read More

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http://dx.doi.org/10.1007/s11882-018-0799-1DOI Listing
July 2018
7 Reads

The Child with Recurrent Mycobacterial Disease.

Curr Allergy Asthma Rep 2018 Jun 23;18(8):44. Epub 2018 Jun 23.

Department of Pediatrics, Allergy-Immunology and Pediatric Rheumatology Division, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.

Purpose Of Review: Many genetic conditions predispose affected individuals to opportunistic infections. A number of immunodeficiency diseases, including genetic defects termed Mendelian susceptibility to mycobacterial disease (MSMD), permit infection from many different strains of mycobacteria that would otherwise not cause disease. These include tuberculous and nontuberculous mycobacteria, and bacille Calmette-Guérin vaccine (BCG). Read More

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http://dx.doi.org/10.1007/s11882-018-0797-3DOI Listing
June 2018
9 Reads

What Is the Relationship Between Eosinophilic Esophagitis (EoE) and Aeroallergens? Implications for Allergen Immunotherapy.

Curr Allergy Asthma Rep 2018 Jun 16;18(8):43. Epub 2018 Jun 16.

Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Colorado, 13123 East 16th Ave, Box 518, Aurora, CO, 80045, USA.

Purpose Of Review: Observations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy.

Recent Findings: The majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results. For various reasons, reaching accurate conclusions based on this methodology is potentially fraught with error. Read More

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http://dx.doi.org/10.1007/s11882-018-0798-2DOI Listing
June 2018
3 Reads

Olfactory Dysfunction in Neurodegenerative Diseases.

Curr Allergy Asthma Rep 2018 Jun 15;18(8):42. Epub 2018 Jun 15.

INGENIO, IRCE, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CELLEX, Department 2B, Villarroel 170, 08036, Barcelona, Catalonia, Spain.

Purpose Of Review: The sense of smell is today one of the focuses of interest in aging and neurodegenerative disease research. In several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, the olfactory dysfunction is one of the initial symptoms appearing years before motor symptoms and cognitive decline, being considered a clinical marker of these diseases' early stages and a marker of disease progression and cognitive decline. Overall and under the umbrella of precision medicine, attention to olfactory function may help to improve chances of success for neuroprotective and disease-modifying therapeutic strategies. Read More

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http://dx.doi.org/10.1007/s11882-018-0796-4DOI Listing
June 2018
29 Reads

Food-Induced Anaphylaxis: an Update.

Curr Allergy Asthma Rep 2018 Jun 14;18(8):41. Epub 2018 Jun 14.

Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Purpose Of Review: This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA).

Recent Findings: Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Read More

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http://dx.doi.org/10.1007/s11882-018-0795-5DOI Listing
June 2018
28 Reads

Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature.

Curr Allergy Asthma Rep 2018 Jun 14;18(8):40. Epub 2018 Jun 14.

Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, DUMC 2918, Durham, NC, 27710, USA.

Purpose Of Review: The goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.

Recent Findings: While the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised district with altered local immune trafficking and neural signaling. In this review, we present two cases in which the development of cutaneous lesions in scars and tattoos was integral to the diagnosis of systemic sarcoidosis. Read More

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http://dx.doi.org/10.1007/s11882-018-0794-6DOI Listing
June 2018
5 Reads

Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches.

Curr Allergy Asthma Rep 2018 Jun 9;18(7):39. Epub 2018 Jun 9.

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose Of Review: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. Read More

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http://link.springer.com/10.1007/s11882-018-0790-x
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http://dx.doi.org/10.1007/s11882-018-0790-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994214PMC
June 2018
5 Reads

Sulfonamide Drug Allergy.

Curr Allergy Asthma Rep 2018 Jun 6;18(7):38. Epub 2018 Jun 6.

Mayo Clinic, Division of Allergic Diseases, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose Of Review: We sought to review past and current literature on sulfonamide drug allergy and distill it in a practical manner to assist the clinician, specifically focusing on cross-reactivity and desensitization.

Recent Findings: There do not appear to be consistent genetic markers to reliably predict features of or the presence hypersensitivity reactions. Recent evidence continues to alleviate early concerns cross-reactivity between sulfonamide antibiotics and non-antibiotics. Read More

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http://dx.doi.org/10.1007/s11882-018-0791-9DOI Listing
June 2018
4 Reads