351 results match your criteria Current Aging Science [Journal]


Brain ageing, cognition and diet: a review of the emerging roles of food-based nootropics in mitigating age-related memory decline.

Curr Aging Sci 2019 Mar 11. Epub 2019 Mar 11.

Behavioural Neuroscience/Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State. Nigeria.

Background: Age-related cognitive decline has been suggested to result from an increase in brain neurone loss, which is attributable to continued derangement of the brain's oxidant/antioxidant balance. Increased oxidative stress and a concomitant decrease in the brain's antioxidant defense system have been associated with functional senescence and organismal ageing. However, nature has configured certain foods to be rich sources of nootropic agents, with research showing that increased consumption of such foods or food ingredients may be protective against ageing-related memory decline. Read More

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http://dx.doi.org/10.2174/1874609812666190311160754DOI Listing
March 2019
1 Read

Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases.

Curr Aging Sci 2019 Feb 3. Epub 2019 Feb 3.

Department of Neurology, Weill Cornell Medicine, New York, New York. United States.

Background/aims: Prodromal Neurodegenerative Disease (ND) due to Alzheimer's disease, Parkinson's disease, and Frontotemporal Lobar Degeneration presents with neurological, psychiatric and medical symptomatology prior to the onset of cognitive changes. Currently, recognition of clinical syndromes during prodromal ND stages is clinically challenging. Fragmentation in care across medical specialties for people with neurological or psychiatric symptoms challenge our ability to recognize clear-cut syndromes because different doctors are paying attention to different aspects of the patient's case. Read More

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http://dx.doi.org/10.2174/1874609812666190204094233DOI Listing
February 2019

Focus on the Different Projects of Telemedicine Centered on the Elderly In France.

Curr Aging Sci 2019 Mar 3. Epub 2019 Mar 3.

Research Unit EA 3072 . France.

Telemedicine is now in vogue, allowing computer and communication tools to be deployed in different fields of health, such as Cardiology, Dermatology, areas in which it has received interest, and in international studies. As the population ages, older people are increasingly concerned about this innovative practice. This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of geriatric subjects in France. Read More

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http://dx.doi.org/10.2174/1874609812666190304115426DOI Listing

Impact of cardiovascular factors on pulse wave velocity and total vascular resistance in different age group patients with cardiovascular disorders.

Curr Aging Sci 2019 Feb 26. Epub 2019 Feb 26.

All India Institute of Medical Sciences, Bhubaneswar, India.

Background Pulse Wave Velocity (PWV) is the propagation speed of the wave-induced along the aorta and arterial tree, each time heartbeats. PWV increases with increased arterial stiffness, thus establishing it as a reliable prognostic marker for cardiovascular morbidity and mortality. On the other hand, total vascular resistance (TVR) is the overall resistance offered by systemic circulation and pulmonary circulation. Read More

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http://dx.doi.org/10.2174/1874609812666190226151500DOI Listing
February 2019

Effects of Ageing on the Mitochondrial Genome in Rat Vestibular Organs.

Curr Aging Sci 2018 ;11(2):108-117

Neurobiology of Ageing and Dementia Laboratory, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.

Background: Deterioration in vestibular function occurs with ageing and is linked to age-related falls. Sensory hair cells located in the inner ear vestibular labyrinth are critical to vestibular function. Vestibular hair cells rely predominantly on oxidative phosphorylation (OXPHOS) for energy production and contain numerous mitochondria. Read More

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http://dx.doi.org/10.2174/1874609811666180830143358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388513PMC
January 2018
5 Reads

Inflammatory biomarkers, depressive symptoms and falls among the elderly in Panama.

Curr Aging Sci 2019 Feb 15. Epub 2019 Feb 15.

Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber. Panama.

Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.

Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.

Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. Read More

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http://dx.doi.org/10.2174/1874609812666190215125104DOI Listing
February 2019
4 Reads

Mitochondrial common deletion level in blood: New insight into the effects of age and Body Mass Index.

Curr Aging Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Medical Genetics, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan. Iran.

Background: Age-related decrease in the mitochondrial activity has been reported in several tissues. Reactive Oxygen Species (ROS) produced from defected mitochondria leads to aging and accumulate through time. However, studies about the mitochondrial DNA mutation level in blood is contradictory. Read More

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http://dx.doi.org/10.2174/1874609812666190201163421DOI Listing
February 2019
1 Read

The Effects of Healthy Ageing on Cerebral Blood Flow Responses to Cognitive Testing.

Curr Aging Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiovascular Sciences, University of Leicester, Leicester. United Kingdom.

Background Transcranial Doppler Ultrasonography (TCD) can be utilised to measure the tight coupling of cerebral blood flow velocity (CBFv) in response to cognitive demand by task activation, termed neurovascular coupling.

Aims: To investigate the differences in neurovascular coupling between healthy older (>50 years) and younger (18-49 years) adults in response to cognitive testing.

Methods: Fifty-four older (n=25) and younger (n=29) adults underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (ETCO2; capnography) monitoring. Read More

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http://www.eurekaselect.com/169535/article
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http://dx.doi.org/10.2174/1874609812666190131165310DOI Listing
January 2019
8 Reads

Changes in Body Composition of Old Rats at Different Time Points after Dexamethasone Administration.

Curr Aging Sci 2019 Jan 14. Epub 2019 Jan 14.

Institute of Sport Sciences and Physiotherapy, University of Tartu. Estonia.

Background: Aging leads to changes in skeletal muscle quantity and quality and is accompanied with increase in body mass and fat mass, whereas fat-free mass either decreases or remains unchanged. The body composition of rodents has been an important factor for clinical trials in the laboratory. Glucocorticoids such as dexamethasone are widely used in clinical medicine, but may induce myopathy, characterized by muscle weakness, atrophy, and fatigue. Read More

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http://dx.doi.org/10.2174/1874609812666190114144238DOI Listing
January 2019
22 Reads

Oxidative and Inflammatory Events in Prion Diseases: Can They Be Therapeutic Targets?

Curr Aging Sci 2019 Jan 10. Epub 2019 Jan 10.

Center for Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697. United States.

Prion diseases are a group of incurable infectious terminal neurodegenerative diseases caused by the aggregated misfolded PrPsc in selected mammals including humans. The complex physical interaction between normal prion protein PrPc and infectious PrPsc causes conformational change from the α- helix structure of PrPc to the β-sheet structure of PrPsc, and this process is repeated. Increased oxidative stress is one of the factors that facilitate conversion of PrPc to PrPsc. Read More

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http://dx.doi.org/10.2174/1874609812666190111100205DOI Listing
January 2019
1 Read

Cognitive Function Prediction of Performance During Dual-Tasks Across Adults With and Without Hearing Loss.

Curr Aging Sci 2018 ;11(3):155-164

Department of Communication Sciences and Disorders, Illinois State University, Normal, IL, United States.

Background: Dual-task procedures are commonly implemented to examine cognitive load and listening effort as individual differences in cognition often determine successful listening. However, which methods are most efficacious is unclear. Specifically, standardized, targeted assessment procedures for establishing cognitive function, and age-related changes that might account for changes in dual-task performance have yet to be established. Read More

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http://dx.doi.org/10.2174/1874609812666181213103209DOI Listing
January 2018
1 Read

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.

Curr Aging Sci 2018 ;11(3):195-200

University of Milano-Bicocca, School of Medicine and Surgery, Monza (MB), Italy.

Introduction: Doege-Potter Syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by Non-Islet Cell Tumor-Induced Hypoglycemia (NICTH) secondary to a Solitary Fibrous Tumor (SFT), which secretes an incompletely processed form of Insulin-like Growth Factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

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http://dx.doi.org/10.2174/1874609812666181205142247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388424PMC
January 2018
11 Reads

Four Principles Regarding an Effective Treatment of Aging.

Authors:
Marios Kyriazis

Curr Aging Sci 2018 ;11(3):149-154

National Gerontology Centre, Larnaca 6021, Cyprus.

The question whether aging is a disease or not, has been asked by many professionals who are involved in the study of age-related degeneration. However, not only an agreement on this remains elusive, but also effective clinical treatments against human aging have not been forthcoming. In this Opinion paper I suggest that the complexity involved in aging is such that we need to remodel our thinking to involve a much more 'systems-oriented' approach. Read More

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http://dx.doi.org/10.2174/1874609811666181025170059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388426PMC
January 2018
2 Reads

Development, Application, and Results from a Precision-medicine Platform that Personalizes Multi-modal Treatment Plans for Mild Alzheimer's Disease and At-risk Individuals.

Curr Aging Sci 2018 ;11(3):173-181

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.

Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative condition in which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all previous single-treatment studies to treat AD have failed, likely because it is a complex disease with multiple underlying drivers contributing to risk, onset, and progression. Here, we explored the efficacy of a multi-therapy approach based on the disease risk factor status specific to individuals with AD diagnosis or concern. Read More

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http://dx.doi.org/10.2174/1874609811666181019101430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388425PMC
January 2018
24 Reads

Daily Living Activities and Cognition in Aged Patients: Effect of Acute Systemic Diseases and Stroke on Leukoaraiosis.

Curr Aging Sci 2018 ;11(2):133-139

National Council of Scientific and Technical Investigations (CONICET), School of Biochemistry and Pharmacy, Oxidative Stress Lab., Institute of Biochemistry and Molecular Medicine (IBIMOL), Junin 954, C1113AAD, CABA, Argentina.

Background: Acute Systemic Diseases (ASD) impact on extended leukoaraiosis (ExLA) have been seldom described. We study the deterioration in daily life activities (DLA) and cognition associated with ASD events compared with the well-described impacts of stroke in patients with leukoaraiosis (L-A).

Methods: Cross-sectional surveys of aged adults from the emergency room after an acute event of ASD or stroke, hospitalized or receiving home care, were followed for one year. Read More

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http://dx.doi.org/10.2174/1874609811666181019103642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388423PMC
January 2018
9 Reads

Behavioral Assessment and Blood Oxidative Status of Aging Sprague Dawley Rats through a Longitudinal Analysis.

Curr Aging Sci 2018 ;11(3):182-194

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Background: Cognitive frailty emerges as one of the threats to healthy aging. It is in continuum with advancing of age with uncertain indicator between pathological and physiological changes. Alterations in pathways associated with the aging process have been observed including oxidative stress, lipid metabolism, and inflammation. Read More

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http://www.eurekaselect.com/166466/article
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http://dx.doi.org/10.2174/1874609811666181019141217DOI Listing
January 2018
20 Reads

Lifestyle Patterns as a Modifiable Risk Factor for Late-life Cognitive Decline: A Narrative Review Regarding Dementia Prevention.

Curr Aging Sci 2018 ;11(2):90-99

School of Arts, Sciences and Humanities of the University of Sao Paulo (USP), Sao Paulo - SP, Brazil.

Background: Dementias due to neurodegenerative disorders and more specifically, Alzheimer's disease (AD) are the most frequent of all diseases within the industrialized world. Besides this alarming fact, it is noted too that almost three-quarter of people with AD reside in low or middle- income nations. In recent years, cognitive and behavioral neuroscientists have focused on a possible correlation between environmental agents and genetic risk factors for these dementias. Read More

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http://www.eurekaselect.com/165927/article
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http://dx.doi.org/10.2174/1874609811666181003160225DOI Listing
January 2018
5 Reads

Altered Gene Expression of Muscle Satellite Cells Contributes to Agerelated Sarcopenia in Mice.

Curr Aging Sci 2018 ;11(3):165-172

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: During aging, muscle tissue undergoes profound changes which lead to a decline in its functional and regenerative capacity. We utilized global gene expression analysis and gene set enrichment analysis to characterize gene expression changes in aging muscle satellite cells.

Method: Gene expression data; obtained from Affymetrix Mouse Genome 430 2. Read More

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http://dx.doi.org/10.2174/1874609811666180925104241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388427PMC
January 2018
3 Reads

Looking Towards New Pathogenetic Mechanisms in Parkinson's Disease: is ANT1 the Potential Candidate?

Curr Aging Sci 2018 ;11(1):71

IRCCS Centro Neurolesi "Bonino-Pulejo" S.S. 113, Contrada Casazza, 98124, Messina, Italy.

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http://dx.doi.org/10.2174/187460981101180727150022DOI Listing
January 2018
1 Read

Understanding Healthy Protective Mechanisms Against Old Age.

Authors:
Debomoy K Lahiri

Curr Aging Sci 2018 ;11(1):2-3

Department of Psychiatry Indiana University School of Medicine Indianapolis, IN, United States.

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http://dx.doi.org/10.2174/187460981101180727124958DOI Listing
January 2018
7 Reads

DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats.

Curr Aging Sci 2018 ;11(2):126-132

Laboratory of Neuro-Humoral Interactions, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brazil.

Background: Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern.

Objective: We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 months-old rats).

Methods: Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Read More

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http://dx.doi.org/10.2174/1874609811666180803125723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388512PMC
January 2018
15 Reads

Pensions and Low Sodium Salt: A Qualitative Evaluation of a New Strategy for Managing Hypertension in Rural South Africa.

Curr Aging Sci 2018 ;11(2):140-146

MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: This paper describes a pilot study to assess the feasibility of a novel intervention to improve the management of hypertension among older people in rural South Africa. Older South Africans have the highest rates of uncontrolled hypertension recorded for any country. Notably, South Africa has a widely-available old age grant (pension), which is delivered on a monthly basis to citizens living in rural villages. Read More

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http://dx.doi.org/10.2174/1874609811666180718114250DOI Listing
January 2018
3 Reads

Role of Exercise on S-Klotho Protein Regulation: A Systematic Review.

Curr Aging Sci 2018 ;11(2):100-107

Department of Medical Physiology, Faculty of Medicine, University of Granada, Granada, Spain.

Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way of treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Read More

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http://dx.doi.org/10.2174/1874609811666180702101338DOI Listing
January 2018
25 Reads

Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes.

Curr Aging Sci 2018 ;11(2):118-125

Discipline of Clinical Immunopathology and Allergy of the School of Medicine of Marilia - FAMEMA. Rua Monte Car-melo, 800, Fragata, CEP: 17519-030, Marilia - SP, Brazil.

Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.

Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.

Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Read More

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http://dx.doi.org/10.2174/1874609811666180605092234DOI Listing
January 2018
3 Reads

At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its Implications.

Curr Aging Sci 2018 ;11(2):77-89

Geriatric Research Education and Clinical Center, VA Boston Healthcare System and the Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School (J.A.D.), Boston, MA, United States.

Background: A growing body of epidemiologic evidence suggests that neurodegenerative diseases occur less frequently in cancer survivors, and vice versa. While unusual, this inverse comorbidity is biologically plausible and could be explained, in part, by the evolutionary tradeoffs made by neurons and cycling cells to optimize the performance of their very different functions. The two cell types utilize the same proteins and pathways in different, and sometimes opposite, ways. Read More

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http://dx.doi.org/10.2174/1874609811666180223154436DOI Listing
January 2018
7 Reads

Patterns and Correlates of Grip Strength in Older Americans.

Curr Aging Sci 2018 ;11(1):63-70

Department of Public Health and Social Work, Slippery Rock University of Pennsylvania, Philadelphia, PA 16057, United States.

Background: Muscle strength is a sensitive indicator of morbidity and mortality in older adults. Loss of muscle strength contributes to a decline in physical functioning. Hand grip strength is a simple measurement but correlated with total body muscle strength. Read More

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http://dx.doi.org/10.2174/1874609810666171116164000DOI Listing
January 2018
6 Reads

Are there Different Kinds of Aging?

Curr Aging Sci 2018 ;11(1):55-62

"Ana Aslan" National Institute of Gerontology and Geriatrics, Bucharest, Romania, 9 Caldarusani, Postal Code 011241, Sector 1, Bucharest, Romania.

Background: Most syndromes of accelerated aging are caused by mutations affecting the integrity of the genetic material. Among them, the most studied is Werner's syndrome, "adult progeria", caused by a recessive autosomal mutation with a frequency of 1 in 10 million, which affects a helicase involved in DNA repair. In Werner syndrome, there is a loss of heterochromatin, though the stability of heterochromatin is also affected in "normal" aging. Read More

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http://www.eurekaselect.com/157245/article
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http://dx.doi.org/10.2174/1874609810666171116163047DOI Listing
January 2018
9 Reads

Physical Activity-does it Really Increase Bone Density in Postmenopausal Women? A Review of Articles Published Between 2001-2016.

Curr Aging Sci 2018 ;11(1):4-9

The Academic College at Wingate, Wingate Institute, Netanya, 4290200, Israel.

Background: Physical activity is known for its many health benefits; among them being the positive effect on bone health during the life cycle. During childhood, physical stress stimulates bone remodeling and increases density. However, due to hormonal changes during adulthood, and mainly during postmenopause the rate of bone remodeling is slowed down and is less efficient. Read More

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http://dx.doi.org/10.2174/1874609810666170918170744DOI Listing
January 2018
9 Reads

The Fall in Older Adults: Physical and Cognitive Problems.

Curr Aging Sci 2017 ;10(3):185-200

UMR 7260 Aix-Marseille Université, Laboratoire de Neurobiologie Intégrative et Adaptatice, Fédération de recherché 3C, 3 place Victor Hugo Case 32, site Saint- Charles 13331 Marseille CEDEX 3, France.

Background: The aging of posture and balance function alters the quality of life in older people and causes serious problems in terms of public health and socio-economic costs for our modern societies.

Method: This article reviews the various causes of imbalance and dizziness in the elderly, and considers how to prevent falls, and how to rehabilitate a faller subject in order to regain a good quality of life. Two effective ways of intervention are discussed, emphasizing the crucial role of physical activity and cognitive stimulation, classic or using the latest technical advances in virtual reality and video games. Read More

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http://dx.doi.org/10.2174/1874609809666160630124552DOI Listing
May 2018
7 Reads

Developing the Transdisciplinary Aging Research Agenda: New Developments in Big Data.

Curr Aging Sci 2018 ;11(1):33-44

University of the Witwatersrand, School of Economic and Business Sciences, Johannesburg, South Africa.

Background: Advances in big data analytics can enable more effective and efficient research processes, with important implications for aging research. Translating these new potentialities to research outcomes, however, remains a challenge, as exponentially increasing big data availability is yet to translate into a commensurate era of 'big knowledge,' or exponential increases in biomedical breakthroughs. Some argue that big data analytics heralds a new era associated with the 'end of theory. Read More

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http://dx.doi.org/10.2174/1874609810666170719100122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110041PMC
January 2018
8 Reads

The Involvement of ERCC2/XPD and ERCC6/CSB Wild Type Alleles in Protection Against Aging and Cancer.

Curr Aging Sci 2018 ;11(1):45-54

Institute of Genetics and Cytology, National Academy of Sciences of Belarus, 27 Akademicheskaya st., Minsk, 220072, Belarus.

Background: DNA helicases maintain genome stability, and their deficiency is associated with disorders resembling premature aging as well as contributes to carcinogenesis. Their functions are determined by the respective genes encoding nucleotide excision repair initiating proteins, e.g. Read More

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http://dx.doi.org/10.2174/1874609810666170707101548DOI Listing
January 2018
11 Reads

Carnosine Treatment Diminished Oxidative Stress and Glycation Products in Serum and Tissues of D-Galactose-Treated Rats.

Curr Aging Sci 2018 ;11(1):10-15

Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Background: Chronic administration of D-galactose (GAL) induces changes that resemble natural aging in rodents. Oxidative stress and Advanced Glycation End products (AGE) formation play a role in GAL-induced aging. Carnosine (CAR; β-alanyl-L-histidine) has antioxidant and anti-glycating actions and may be a potential therapeutic agent in aging due to these properties. Read More

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http://dx.doi.org/10.2174/1871530317666170703123519DOI Listing
January 2018
11 Reads

Is Longevity a Heritable Trait? Evidence for Non-genomic Influence from an Extended Longevity Phenotype of Drosophila melanogaster.

Curr Aging Sci 2018 ;11(1):24-32

Unit on Evolution and Genetics, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru -570 006, India.

Background: Although genetic variations are heritable, some quantitative traits like longevity may have non-genomic influence on heritability. Laboratory-selected inbred strains of extended longevity phenotype of Drosophila offer an opportunity to study the inheritance of longevity.

Objective: The aim of the study was to examine the heritability of longevity in an extended longevity phenotype of Drosophila melanogaster using reciprocal cross effects in F1 and F2 generations. Read More

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http://dx.doi.org/10.2174/1874609810666170615120942DOI Listing
January 2018
22 Reads

Ursolic Acid Mediates Hepatic Protection through Enhancing of anti-aging Biomarkers.

Curr Aging Sci 2018 ;11(1):16-23

Department of Internal- Medicine, Faculty of Medical-sciences, Medical University of Kermanshah, Kermanshah, Iran.

Background: Age-associated loss of liver function has been recognized for decades. But, the mechanism driving liver regeneration and its decline with age remains elusive.

Objective: Hence, to support of our previous studies about anti-aging effects of Ursolic Acid (UA), a compound which is extensively present in apple peels. Read More

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http://www.eurekaselect.com/152808/article
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http://dx.doi.org/10.2174/1874609810666170531103140DOI Listing
January 2018
14 Reads

Cytoskeleton-Anchoring of Conformational Mutant-Like p53, but Not Shorter Isoforms p53β and p47 (ΔN40p53) in Senescent Human Fibroblasts.

Authors:
Koji Nishio

Curr Aging Sci 2017 ;10(4):291-304

Department of Anatomy and Neurosciences, Nagoya University, Graduate School of Medicine, 65 Tsurumai- Cho, Showa-Ku, Nagoya 466-8550. Japan.

Background: Cytoskeleton anchoring of conformational mutant-like p53 is prominent in human senescent cells. The present research investigated the structural basis of vimentin cytoskeleton- anchoring of human p53.

Method: GFP-fused wild type p53, mutant p53, those of the various truncated isoforms including p53β and p47, were expressed in the vimentin-expressing cells: mouse fibroblasts, COS-7 cells, young and senescent human fibroblasts, and HeLa cells (non-vimentin-expressing). Read More

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http://dx.doi.org/10.2174/1874609810666170523153639DOI Listing
June 2018
13 Reads

The Click Test: A Novel Tool to Quantify the Age-Related Decline of Fast Motor Sequencing of the Thumb.

Curr Aging Sci 2017 ;10(4):305-318

Clinical and Experimental Neurolinguistics, Vrije Universiteit Brussel, Brussels. Belgium.

Background: The thumb plays a critical role for manual tasks during the activities of daily life and the incidence of neurological or musculoskeletal disorders affecting the voluntary movements of the thumb is high in the elderly. There is currently no tool to assess repetitive motor sequencing of the thumb during ageing.

Objectives: To report a novel procedure (the Click Test) assessing the effects of ageing on fast motor sequencing of the thumb. Read More

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http://dx.doi.org/10.2174/1874609810666170511100318DOI Listing
June 2018
17 Reads

Acute Symptomatic Seizures in Geriatric Patients with Multiple Risk Factors - A Diagnostic Challenge.

Curr Aging Sci 2017 ;10(4):263-269

Klinik fur Neurologie, Westpfalz-Klinikum, Hellmut-Hartert-Str. 1, D-67655 Kaiserslautern. Germany.

Background: Acute symptomatic seizures and epileptic disorders are frequent health problems of elderly patients. An early and reliable distinction of the seizure etiology is important to ensure adequate treatment, and to prevent unwarranted diagnostic and therapeutic procedures.

Methods: We review the current literature based on a MEDLINE search, describe age-related problems in detail, with particular attention to clinical practice, discuss possible criteria and potential pitfalls for diagnostics, and provide a compilation of etiologic factors for acute symptomatic seizures. Read More

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http://dx.doi.org/10.2174/1874609810666170413123317DOI Listing
June 2018
10 Reads

Support and Social Contact as a Decisive Meta-Variable in Morbidity and Social Welfare of the Older Person.

Curr Aging Sci 2017 ;10(4):282-290

Hospital Virgen del Valle, Toledo University Complex, Toledo. Spain.

Bacground: This article tackles social support as a meta-variable that is reinforced by a set of social variables, which correlate and act as predictors of social welfare and life quality of the older person.

Objective: The objective of the study is to know how social support, networks and social contacts can influence the health of the elderly person, especially if these are interrelated factors.

Method: The population studied are individuals from both sexes living in Toledo (Spanish people) and who were 65 years of age or over. Read More

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http://dx.doi.org/10.2174/1874609810666170413124209DOI Listing
June 2018
16 Reads

Neurons vs. Germline: A War of Hormetic Tradeoffs.

Authors:
Marios Kyriazis

Curr Aging Sci 2017 ;10(4):242-245

ELPIs Foundation for Indefinite Lifespans, York Road, London TW10 6DR. United Kingdom.

The process of human ageing is significantly dependent upon events which are currently shaping humanity. One such event is the seemingly inexorable progress of technology, and specifically, digital communications technology. Technology and biology are tightly interconnected, and this has a direct relevance on how our own ageing mechanisms are evolving and adapting to the change. Read More

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http://dx.doi.org/10.2174/1874609810666170413123547DOI Listing
June 2018
6 Reads

Late versus Early Onset Depression in Elderly Patients: Vascular Risk and Cognitive Impairment.

Curr Aging Sci 2017 ;10(3):211-216

Psychiatry Department, Faculty of Medicine, Cairo University, Cairo. Egypt.

Background: Three-quarters of patients with major depressive disorder have late-onset depression. Late-onset depression is more often associated with cognitive impairment than earlyonset depression and evidences showed a relationship between vascular factors and late-life depression.

Objectives: To compare cognitive functions between late-onset (&ge;60 years) and early-onset (<60 years) depression in elderly patients and to highlight the effect of vascular risk factors in elderly patients with late and early onset depression. Read More

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http://dx.doi.org/10.2174/1874609810666170404105634DOI Listing
May 2018
45 Reads

Protein Tyrosine Nitration: Role in Aging.

Curr Aging Sci 2017 ;10(4):246-262

Department of Chemistry, York College, The City University of New York, 94-20 Guy R. Brewer Boulevard, Jamaica, New York. United States.

Background: Aging is the inevitable fate of all living organisms, but the molecular basis of physiological aging is poorly understood. Oxidative stress is believed to play a key role in the aging process. In addition to Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS) are generated during aerobic metabolism in living organisms. Read More

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http://dx.doi.org/10.2174/1874609810666170315112634DOI Listing
June 2018
11 Reads

Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer's and Parkinson's Diseases.

Curr Aging Sci 2017 ;10(3):158-176

Department of Biology, The Irving K. Barber School of Arts and Sciences, University of British Columbia Okanagan Campus, Kelowna, BC, Canada.

Background: Alzheimer's Disease (AD) and Parkinson's Disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent and aberrant microglial activation in the brain, which results in damage and death of neighboring cells, including neurons and glial cells. Read More

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http://dx.doi.org/10.2174/1874609810666170315113244DOI Listing
May 2018
60 Reads

Introduction.

Curr Aging Sci 2017 ;10(1):4-5

Department of Biochemistry Institute of Bioregulation and Gerontology St. Petersburg, 3 Dynamo av. St. Petersburg Russia ; Department of Immunology and Cell Cooperation D.O. Ott Institute of Obstetrics, Gynecology and Reproductology 3, Mendeleyevskaya Line, St. Petersburg. Russian Federation.

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October 2018
15 Reads

Editorial: Denham Harman - Pioneer of the Free Radical Theory of Aging.

Curr Aging Sci 2017 ;10(1)

Biochemical Department St. Petersburg Institute of Bioregulation and Gerontology 3, Dynamo Ave., St. Petersburg ; Department of Immunology and Cell Cooperation D.O. Ott Institute of Obstetrics, Gynecology and Reproductology 3, Mendeleyevskaya Line, St. Petersburg. Russian Federation.

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October 2018
7 Reads

Metabolic and Cardiovascular Ageing Indices in Relation to Glycated Haemoglobin in Healthy and Diabetic Subjects.

Curr Aging Sci 2017 ;10(3):201-210

Department of General Medicine, K.S. Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.

Background: Ageing is a natural phenomenon that has tremendous amount of control over normal physiological functions. Diabetes mellitus and ageing share common symptoms like stiffness and loss of functioning of tissues due to cross-liked proteins and free radicals. Glycated Haemoglobin (HbA1c) is often used as a stable cumulative index of glycemic control and has shown that even in non-diabetic adults, there is a steady increase in HbA1c levels with age. Read More

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http://dx.doi.org/10.2174/1874609810666170216124039DOI Listing
May 2018
9 Reads

Life History Traits of an Extended Longevity Phenotype of Drosophila melanogaster.

Curr Aging Sci 2017 ;10(3):224-238

Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru-570 006, Karnataka, India.

Background: Aging or senescence is a complex biological phenomenon. Artificially selected Drosophila for extended longevity is one of the experimental models used to understand the mechanisms involved in aging and to test various theories.

Objective: To examine the life history traits and biochemical defenses in relation to aging in an extended longevity phenotype of Drosophila melanogaster. Read More

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http://dx.doi.org/10.2174/1874609810666170209111350DOI Listing
May 2018
13 Reads

A Random Forest-Induced Distance-Based Measure of Physiologic al Dysregulation.

Curr Aging Sci 2017 ;10(4):270-281

Department of Mathematics & Physical Sciences, Louisiana State University of Alexandria, Alexandria, LA 71302. United States.

Background: Aging involves gradual, multisystemic Physiological Dysregulation (PD) which increases risk of age-related comorbidities. Ability to quantify age-related PD could provide insights into biological mechanisms underlying the aging process. One approach to measuring PD exploits the fact that increasing PD manifests as a gradual deviation of physiological parameters away from normal levels. Read More

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http://dx.doi.org/10.2174/1874609810666170117155756DOI Listing
June 2018
8 Reads

Investigating Physical, Psychological and Social Well-being of Older Persons in Jordan.

Curr Aging Sci 2017 ;10(3):217-223

School of Nursing, The University of Jordan, Amman 11942, Jordan.

Background: Older persons are overwhelmed with psychological stressors due to requirements related to the management of their health problems. The purpose of this study was to investigate physical, psychological and social wellbeing of older persons.

Method: Cross-sectional explorative design used convenience sample of 1058 older persons in Jordan. Read More

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http://dx.doi.org/10.2174/1874609810666170113093307DOI Listing
May 2018
9 Reads

Factors of Rapid Cognitive Decline in Late Onset Alzheimer's Disease.

Curr Aging Sci 2017 ;10(2):129-135

Department of Psycho-Geriatrics, Bretonneau Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, 23 rue Joseph de Maistre 75018 Paris, France.

Background: Rapid Cognitive Decline (RCD) in Alzheimer's Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD.

Objective: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD. Read More

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http://dx.doi.org/10.2174/1874609810666170102143257DOI Listing
May 2018
12 Reads

Oxidative Stress, Pro-Inflammatory Cytokines, and Antioxidants Regulate Expression Levels of MicroRNAs in Parkinson's Disease.

Authors:
Kedar N Prasad

Curr Aging Sci 2017 ;10(3):177-184

Engage Global, 245 El-Faisan Drive, San Rafael, CA 94903, United States.

Background: Parkinson's disease (PD) is a slow progressive neurodegenerative disease associated with abnormal function of extrapyramidal system. Although several biochemical and genetic defects are identified, increased oxidative stress and chronic inflammation are one of the earliest events that initiate and promote PD. Oxidative stress also participates in impaired nonmotor symptoms. Read More

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http://dx.doi.org/10.2174/1874609810666170102144233DOI Listing
May 2018
20 Reads