220,068 results match your criteria Culture health & sexuality[Journal]


CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.

PLoS Genet 2019 Apr 24;15(4):e1008034. Epub 2019 Apr 24.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008034
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http://dx.doi.org/10.1371/journal.pgen.1008034DOI Listing
April 2019
1 Read

Detecting Developmental Delay and Autism Through Machine Learning Models Using Home Videos of Bangladeshi Children: Development and Validation Study.

J Med Internet Res 2019 Apr 24;21(4):e13822. Epub 2019 Apr 24.

Division of Systems Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, United States.

Background: Autism spectrum disorder (ASD) is currently diagnosed using qualitative methods that measure between 20-100 behaviors, can span multiple appointments with trained clinicians, and take several hours to complete. In our previous work, we demonstrated the efficacy of machine learning classifiers to accelerate the process by collecting home videos of US-based children, identifying a reduced subset of behavioral features that are scored by untrained raters using a machine learning classifier to determine children's "risk scores" for autism. We achieved an accuracy of 92% (95% CI 88%-97%) on US videos using a classifier built on five features. Read More

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http://dx.doi.org/10.2196/13822DOI Listing

Strengthening nursing surveillance in general wards: a practice development approach.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

Conjoint Associate Professor, Metro North Hospital and Health Service, Herston QLD, Australia.

Aim: To explore the context and culture of nursing surveillance on an acute care ward.

Background: Prevention of patient deterioration is primarily a nursing responsibility in hospital. Registered nurses make judgements and act on emerging threats to patient safety through a process of nursing surveillance. Read More

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http://dx.doi.org/10.1111/jocn.14890DOI Listing

Patient safety culture in Hungarian hospitals.

Int J Health Care Qual Assur 2019 Mar;32(2):412-424

Department of Nursing, Universitat Autònoma de Barcelona , Barcelona, Spain.

Purpose: The Hospital Survey on Patient Safety Culture (HSOPSC) is a rigorously designed tool for measuring inpatient safety culture. The purpose of this paper is to develop a cross-cultural HSOPSC for Hungary and determine its strengths and weaknesses.

Design/methodology/approach: The original US version was translated and adapted using existing guidelines. Read More

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http://dx.doi.org/10.1108/IJHCQA-02-2018-0048DOI Listing

Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans.

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.

The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of novel pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis led us to explore the overlooked function of MPI and mannose metabolism in liver development and adult liver diseases. Herein, analyses of transcriptomic data from three human liver cohorts demonstrate that MPI gene expression is downregulated proportionate to fibrosis in chronic liver diseases, including non-alcoholic fatty liver disease and hepatitis B virus. Read More

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http://dx.doi.org/10.1002/hep.30677DOI Listing

Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis.

Methods Mol Biol 2019 ;1981:313-323

Division of National Toxicology Program, National Institute of Environmental Health Sciences, Durham, NC, USA.

Cholestasis remains a major challenge in drug-induced liver injury, and therefore warrants identification of chemical entities that may lead to cholestasis. Recent advances in cell culture methods enable 3D spheroid models to remain viable for much longer periods of time than conventional sandwich cultures of primary human hepatocytes while maintaining native tissue-like functionality, such as drug metabolism activity, receptor signaling functionality, and physiological relevance. These spheroid models enable us to study repeated exposure effects associated with chemicals and their metabolites that may ultimately progress to cholestasis and liver injury. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_20DOI Listing
January 2019

Heterogeneity in Adipose Stem Cells.

Adv Exp Med Biol 2019 ;1123:119-150

Centre for Advanced Studies in Humanities and Health Sciences, Interamerican Open University, Buenos Aires, Argentina.

Adipose stem cells (ASCs) are the basis of procedures intended for tissue regeneration. These cells are heterogeneous, owing to various factors, including the donor age, sex, body mass index, and clinical condition; the isolation procedure (liposuction or fat excision); the place from where the cells were sampled (body site and depth of each adipose depot); culture surface; type of medium (whether supplemented with fetal bovine serum or xeno-free), that affect the principal phenotypic features of ASCs. The features related to ASCs heterogeneity are relevant for the success of therapeutic procedures; these features include proliferation capacity, differentiation potential, immunophenotype, and the secretome. Read More

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http://dx.doi.org/10.1007/978-3-030-11096-3_8DOI Listing
January 2019

Defining Compulsive Behavior.

Neuropsychol Rev 2019 Apr 23. Epub 2019 Apr 23.

Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Compulsive tendencies are a central feature of problematic human behavior and thereby are of great interest to the scientific and clinical community. However, no consensus exists about the precise meaning of 'compulsivity,' creating confusion in the field and hampering comparison across psychiatric disorders. A vague conceptualization makes compulsivity a moving target encompassing a fluctuating variety of behaviors, which is unlikely to improve the new dimension-based psychiatric or psychopathology approach. Read More

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http://dx.doi.org/10.1007/s11065-019-09404-9DOI Listing

The Prevalence and Health Impacts of Frequent Work Discrimination and Harassment among Women Firefighters in the US Fire Service.

Biomed Res Int 2019 20;2019:6740207. Epub 2019 Mar 20.

Institute for Biobehavioral Health Research, National Development & Research Institutes, 1920 W. 143rd Street, Suite 120, Leawood, KS 66224, USA.

Intro: Both discrimination and harassment directly impact mental and physical health. Further, workplace discrimination degrades workplace culture and negatively impacts health behaviors, job-related outcomes, and family dynamics. Women represent a small proportion of the fire service and are often the targets of discrimination/harassment, yet little research documents the impact of such experiences. Read More

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https://www.hindawi.com/journals/bmri/2019/6740207/
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http://dx.doi.org/10.1155/2019/6740207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446094PMC
March 2019
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Infection Triggering Acute Relapse in Pediatric Crohn's Disease.

Case Rep Infect Dis 2019 20;2019:2094372. Epub 2019 Mar 20.

Department of Pediatrics, Western University, London, Ontario, Canada N6A 3K7.

Crohn's disease exacerbations can often be associated with bacterial infections causing gastroenteritis. We report a child who experienced exacerbation of his Crohn's disease associated with a positive stool culture for . Endoscopy showed features of moderate inflammation similar to exacerbation of Crohn's disease. Read More

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http://dx.doi.org/10.1155/2019/2094372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446101PMC

Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea.

Allergy Asthma Clin Immunol 2019 16;15:23. Epub 2019 Apr 16.

2Department of Anesthesia, McGill University Health Center, 1001 Decarie Boulevard, Montreal, QC H4A 3J1 Canada.

Background: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and systemic inflammation. However, the sequence of events leading to the morbidities associated with OSA is poorly understood in children. Read More

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http://dx.doi.org/10.1186/s13223-019-0338-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469051PMC

Addressing the rising rates of gonorrhea and drug-resistant gonorrhea: There is no time like the present.

Can Commun Dis Rep 2019 Feb 7;45(2-3):54-62. Epub 2019 Feb 7.

Bacterial Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

Increasing rates of gonococcal (GC) infection and antimicrobial resistant (AMR) GC, are a serious public health concern for Canada and around the world. Previously recommended treatments are ineffective against many of the gonorrhea strains circulating today. The current recommendation for combination therapy is now being threatened by globally emerging and increasingly resistant strains. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v45i23a02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461120PMC
February 2019
1 Read

Rat bite fever on Vancouver Island: 2010-2016.

Can Commun Dis Rep 2018 Sep 6;44(9):215-219. Epub 2018 Sep 6.

University of British Columbia, Vancouver, BC.

Background: Rat bite fever (RBF) is a rare bacterial zoonotic infection caused by and which are found naturally in rodent respiratory tracts. Recently, multiple cases of RBF were observed on Vancouver Island, British Columbia.

Objective: To conduct a case series analysis of cases of RBF on Vancouver Island between 2010 and 2016 to characterize the epidemiology, presentation, microbiology and treatment of RBF. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449109PMC
September 2018

User-defined morphogen patterning for directing human cell fate stratification.

Sci Rep 2019 Apr 23;9(1):6433. Epub 2019 Apr 23.

Department of Bioengineering, University of Washington, 98195, Seattle, USA.

Concentration gradients of biochemical stimuli such as morphogens play a critical role in directing cell fate patterning across species and throughout development but are not commonly recapitulated in vitro. While in vitro biomolecule gradients have been generated using customized microfluidic platforms, broad implementation has been limited because these platforms introduce new variables to cell culture such as externally driven flow, culture in a specialized matrix, or extended time for in situ long range diffusion. Here we introduce a method that enables preforming and then transferring user-controlled gradients to cells in standard "open" cultures. Read More

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http://dx.doi.org/10.1038/s41598-019-42874-8DOI Listing

QMRA of adenovirus in drinking water at a drinking water treatment plant using UV and chlorine dioxide disinfection.

Water Res 2019 Apr 1;158:34-45. Epub 2019 Apr 1.

National Institute of Public Health and the Environment, Bilthoven, the Netherlands.

According to the Dutch Drinking Water Act of 2011, Dutch drinking water suppliers must conduct a Quantitative Microbial Risk Assessment (QMRA) for infection by the following index pathogens: enterovirus, Campylobacter, Cryptosporidium and Giardia at least once every four years in order to assess the microbial safety of drinking water. The health-based target for safe drinking water is set at less than one infection per 10 000 persons per year. At Evides Water Company, concern has arisen whether their drinking water treatment, mainly based on UV inactivation and chlorine dioxide, reduces levels of adenovirus (AdV) sufficiently. Read More

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http://dx.doi.org/10.1016/j.watres.2019.03.090DOI Listing

Title: 2,3,7,8-tetrachloodibenzo-p-dioxin affects the differentiation of CD4 helper T cell.

Toxicol Lett 2019 Apr 20. Epub 2019 Apr 20.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic congener of dioxins, is a persistent and ubiquitous environmental contaminant. Although the immunotoxic effects of TCDD have been reported, the mechanisms underlying these effects are still unclear. In this study, we have determined the toxic effects of TCDD on thymocytes and splenic T cells with in vitro cell culture systems. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.04.015DOI Listing

Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute disseminated canine Chagas disease.

Vet Parasitol Reg Stud Reports 2018 05 22;12:85-88. Epub 2018 Feb 22.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, MS4458, TX 77843-4458, United States. Electronic address:

In 2006, Nabity et al. reported on an atypical presentation of Trypanosoma cruzi (T. cruzi) infection in an 8-month old English Mastiff from central Texas. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.02.006DOI Listing

Implementation of a multicomponent intervention to prevent physical restraints in nursing homes (IMPRINT): A pragmatic cluster randomized controlled trial.

Int J Nurs Stud 2019 Apr 4. Epub 2019 Apr 4.

Institute of Health and Nursing Science, Medical Faculty, Martin Luther University Halle-Wittenberg, Magdeburger Str. 8, 06112 Halle (Saale), Germany; School of Nursing Science, Faculty of Health, Witten/Herdecke University, Stockumer Str. 12, 58453 Witten, Germany. Electronic address:

Background: Despite clear evidence for the lack of effectiveness and safety, physical restraints are frequently applied in nursing homes. Multicomponent interventions addressing nurses' attitudes and organizational culture have been effective in reducing physical restraints.

Objective: To evaluate the effectiveness of two versions of a guideline and theory-based multicomponent intervention to reduce physical restraints in nursing homes. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2019.03.017DOI Listing

[Current status of antibiotic therapy for Staphylococcus aureus sepsis in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):387-392

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Objective: To investigate the current status of empirical antibiotic therapy for children with Staphylococcus aureus sepsis and the effect of therapeutic paradigm on prognosis based on a retrospective analysis.

Methods: A total of 78 children with Staphylococcus aureus sepsis who were admitted from January 2014 to August 2017 were enrolled. According to the preferred empirical antibiotics before the detection of Staphylococcus aureus by blood culture, these children were divided into a carbapenem group with 16 children, a β-lactam group with 37 children, a vancomycin group with 15 children and a vancomycin+β-lactam group with 10 children. Read More

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April 2019
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Conceptual model of managing health care volunteers in disasters: a mixed method study.

BMC Health Serv Res 2019 Apr 24;19(1):241. Epub 2019 Apr 24.

Reproductive Health, Research Center for Nursing and Midwifery Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Shortage of specialized healthcare volunteers is a major challenge during disasters and one solution could be pre-identified healthcare volunteers. This study aimed to develop a conceptual model of managing Iranian healthcare volunteers in disasters.

Methods: This mixed method study was designed in two phases. Read More

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http://dx.doi.org/10.1186/s12913-019-4073-6DOI Listing

Magnitude of delayed turnaround time of laboratory results in Amhara Public Health Institute, Bahir Dar, Ethiopia.

BMC Health Serv Res 2019 Apr 24;19(1):240. Epub 2019 Apr 24.

Amhara Public Health Institute, P.O.Box 447, Bahir Dar, Amhara, Ethiopia.

Background: Clinical decisions depend on timely laboratory result reporting. The timeliness is commonly expressed in turnaround time and serves as a quality improvement tool to assess the effectiveness and efficiency of the laboratory. According to the International Organization for Standardization (ISO) guidelines, each laboratory shall establish turnaround times for each of its examinations that reflect clinical needs, and shall periodically evaluate whether or not it is meeting the established turnaround times. Read More

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http://dx.doi.org/10.1186/s12913-019-4077-2DOI Listing

Associations of education and income with heavy drinking and problem drinking among men: evidence from a population-based study in Japan.

BMC Public Health 2019 Apr 23;19(1):420. Epub 2019 Apr 23.

Department of Health and Social Behavior, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Some studies in Western countries have suggested that education and income are differentially associated with different drinking patterns. This study aimed to examine the associations of education and income with heavy drinking and problem drinking among community-dwelling Japanese men.

Methods: A questionnaire survey was conducted in metropolitan areas in Japan from 2010 to 2011 among residents aged 25 to 50 years; valid responses were received from 2004 men. Read More

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http://dx.doi.org/10.1186/s12889-019-6790-5DOI Listing

Hemoglobin A1c and 10-year information processing speed in Japanese community dwellers.

Environ Health Prev Med 2019 Apr 23;24(1):24. Epub 2019 Apr 23.

Section of NILS-LSA, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi, 474-8511, Japan.

Background: Hyperglycemia is believed to be a risk factor for cognitive decline, but the longitudinal relationship between hyperglycemia and cognitive decline in the Japanese population is unclear. The present study aimed to clarify the association between blood glucose levels and information processing ability in middle-aged and older adults.

Methods: The subjects were 866 men and 815 women aged 40-79 years not taking medication for diabetes who participated in the first study wave (1997-2000) and then participated at least once in the subsequent six study waves (2000-2012) of the National Institute for Longevity Sciences-Longitudinal Study of Aging, Japan. Read More

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http://dx.doi.org/10.1186/s12199-019-0778-8DOI Listing

Exemplification and Stigmatization of the Depressed: Depression as the Main Topic versus an Incidental Topic in National US News Coverage.

Authors:
Weirui Wang

Health Commun 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Department of Communication , Florida International University.

To understand the associations between the use of exemplars and other communication themes known to contribute to the stigmatization of the depressed, we conducted a content analysis of news stories about depression in three national media outlets - CNN.com, The New York Times, and The Washington Post (N = 986). The study found exemplars were often used in the coverage of depression by national news outlets. Read More

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https://www.tandfonline.com/doi/full/10.1080/10410236.2019.1
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http://dx.doi.org/10.1080/10410236.2019.1606874DOI Listing

C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Oral Health Science Research Center, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan.

Cancer is a leading cause of death and disease worldwide, with a tremendous financial impact. Thus, the development of cost-effective novel approaches for suppressing tumor growth and progression is essential. In an attempt to identify the mechanisms responsible for tumor suppression, we screened for molecules downregulated in a cancer progression model and found that the chemokine CXCL14, also called BRAK, was the most significantly downregulated. Read More

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http://dx.doi.org/10.3390/ijms20081872DOI Listing

Characteristics and Challenges for the Development of Nature-Based Adult Day Services in Urban Areas for People with Dementia and Their Family Caregivers.

Int J Environ Res Public Health 2019 Apr 14;16(8). Epub 2019 Apr 14.

Center for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

Nature-based adult day services (ADSs) for people with dementia (PwD) are well-known in rural areas. In recent years, a number of providers have started offering these services in urban contexts, e.g. Read More

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http://dx.doi.org/10.3390/ijerph16081337DOI Listing

Real-Time Continuous Surveillance of Temperature and Flow Events Presents a Novel Monitoring Approach for Hospital and Healthcare Water Distribution Systems.

Int J Environ Res Public Health 2019 Apr 13;16(8). Epub 2019 Apr 13.

College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.

Within hospitals and healthcare facilities opportunistic premise plumbing pathogens (OPPPs) are a major and preventable cause of healthcare-acquired infections. This study presents a novel approach for monitoring building water quality using real-time surveillance of parameters measured at thermostatic mixing valves (TMVs) across a hospital water distribution system. Temperature was measured continuously in real-time at the outlet of 220 TMVs located across a hospital over a three-year period and analysis of this temperature data was used to identify flow events. Read More

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http://dx.doi.org/10.3390/ijerph16081332DOI Listing

Improving the Living, Learning, and Thriving of Young Black Men: A Conceptual Framework for Reflection and Projection.

Authors:
Daphne C Watkins

Int J Environ Res Public Health 2019 Apr 13;16(8). Epub 2019 Apr 13.

School of Social Work, University of Michigan, Ann Arbor, MI 48109, USA.

Black men experience disproportionate mental health challenges due to their exposure to severe psychosocial stressors. Yet, the mental health challenges of Black men have largely been left out of national conversations. Strong theoretical frameworks are important when generating dialogue about the mental health of Black men, as it helps to validate the work on a larger scale while also grounding the work for more practical use. Read More

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http://dx.doi.org/10.3390/ijerph16081331DOI Listing

Ultrastructural Features of Human Liver Specimens from Patients Who Died of Dengue Hemorrhagic Fever.

Trop Med Infect Dis 2019 Apr 12;4(2). Epub 2019 Apr 12.

Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Recent advances in electron microscopy and tomography have revealed distinct virus-induced endoplasmic reticulum (ER) structures unique for dengue virus (DV) and other flaviviruses in cell culture models, including hepatocytes. These altered ultrastructures serve as sites for viral replication. In this study, we used transmission electron microscopy to investigate whether such structures were present in the liver of fatal dengue hemorrhagic fever (DHF) autopsy cases. Read More

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http://dx.doi.org/10.3390/tropicalmed4020063DOI Listing

Evaluation of Polyphenolic Compounds and Pharmacological Activities in Hairy Root Cultures of Turcz. f. (Nakai).

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Korea.

A considerable amount of bioactive compounds have been used for the biopharmaceutical engineering to help human health and nutrition. Hairy root culture (HRC) or transgenic root is a favourable alternative technique for phytochemical production. is a significant source of pharmaceutically important active compounds with an enormous range of health care applications. Read More

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http://dx.doi.org/10.3390/molecules24081586DOI Listing

The Association between Chronicity of Migraine and Complementary and Alternative Medication Use: The Turkish Perspective.

Eur Neurol 2019 Apr 23;81(1-2):24-29. Epub 2019 Apr 23.

Department of Neurology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey,

Background And Purpose: The term of Complementary and Alternative Medication (CAM) is described by patients as all types of practices to prevent or treat illnesses, which are not currently considered as a part of conventional medicine. Although the advance in treatment for migraine, some patients prefer CAM therapies due to their concerns about conventional therapies. The aim of this study was to evaluate the association between CAM use and chronicity of migraine among Turkish migraineurs. Read More

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https://www.karger.com/Article/FullText/499910
Publisher Site
http://dx.doi.org/10.1159/000499910DOI Listing
April 2019
4 Reads

The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions.

Transfusion 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. Read More

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http://dx.doi.org/10.1111/trf.15317DOI Listing
April 2019
1 Read

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures.

PLoS Med 2019 Apr 23;16(4):e1002786. Epub 2019 Apr 23.

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, United States of America.

Background: The World Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tuberculosis infection (LTBI) to ATB. A large number of host-derived blood-based gene-expression biomarkers for diagnosis of patients with ATB have been proposed to date, but none have been implemented in clinical settings. The focus of this study is to directly compare published gene signatures for diagnosis of patients with ATB across a large, diverse list of publicly available gene expression datasets, and evaluate their performance against the WHO/FIND TPPs. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002786DOI Listing

How Confidence in Prior Attitudes, Social Tag Popularity, and Source Credibility Shape Confirmation Bias Toward Antidepressants and Psychotherapy in a Representative German Sample: Randomized Controlled Web-Based Study.

J Med Internet Res 2019 Apr 23;21(4):e11081. Epub 2019 Apr 23.

Knowledge Construction Lab, Knowledge Media Research Center, Leibniz-Institut für Wissensmedien, Tuebingen, Germany.

Background: In health-related, Web-based information search, people should select information in line with expert (vs nonexpert) information, independent of their prior attitudes and consequent confirmation bias.

Objective: This study aimed to investigate confirmation bias in mental health-related information search, particularly (1) if high confidence worsens confirmation bias, (2) if social tags eliminate the influence of prior attitudes, and (3) if people successfully distinguish high and low source credibility.

Methods: In total, 520 participants of a representative sample of the German Web-based population were recruited via a panel company. Read More

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http://dx.doi.org/10.2196/11081DOI Listing

Long-term in vitro treatment with telomerase inhibitor MST-312 induces resistance by selecting long telomeres cells.

Cell Biochem Funct 2019 Apr 23. Epub 2019 Apr 23.

Multidisciplinary Laboratory of Human Health, University of Brasilia, Brasília, Brazil.

Telomerase is a good target for new anticancer drug development because it is present in over 85% of human tumours. However, despite chronic therapy is a condition for anti-telomerase approach, the effects of long-term treatment with telomerase inhibitors remain not well understood. In this work, it was evaluated the effects of long-term treatment of human MDA-MB-231 breast cancer cells with the telomerase inhibitor MST-312. Read More

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http://dx.doi.org/10.1002/cbf.3398DOI Listing

Nursing's future? Eat young. Spit out. Repeat. Endlessly.

J Nurs Manag 2019 Apr 23. Epub 2019 Apr 23.

School of Nursing, University of Hull, Hull, UK.

The continuation of nursing's systemic problem of bullying and abuse of students and colleagues has been allowed to continue for generations. It is now accepted by many as an inevitable part of the nursing and healthcare landscape. In brief, it is now part of 'who we are' as nurses and health professionals. Read More

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http://dx.doi.org/10.1111/jonm.12781DOI Listing

Celluloid zombies: A research study of nurses in zombie-focused feature films.

J Adv Nurs 2019 Apr 22. Epub 2019 Apr 22.

Charles Sturt University.

Aim: To explore how nurses, who are the principal character of zombie-focused feature films are portrayed.

Design: A mixed methods study with a quantitative exploration of 44,000 feature film synopsis and additional online material for films made between 1900 - 2018 was used. Zombie-focused films (485) were reviewed for their genre, county, year of production and plot-lines. Read More

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http://dx.doi.org/10.1111/jan.14036DOI Listing

Shouldn't we all be clinical academics?

J Adv Nurs 2019 Apr 22. Epub 2019 Apr 22.

Reader in Health Services Research, School of Nursing, University of Central Lancashire, Senior Research Fellow, NIHR CLAHRC North West Coast.

This recent tweet by the President of the Royal College of Nursing highlighted concern about the perennial lack of funding and support for nurses to pursue clinical academic careers. Although there are multiple interpretations of what 'participating in research' actually consists of, it is apparent that research activity is still undervalued and under-resourced in nursing. The development of an integrated clinical academic (ICA) career pathway in nursing in the past decade has been underpinned by the growing academisation and research culture of both nursing education and clinical practice, highlighted in the Willis Report (Health Education England, 2015). Read More

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http://dx.doi.org/10.1111/jan.14026DOI Listing

Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Commonly used monolayer cancer cell cultures fail to provide a physiologically relevant environment in terms of oxygen delivery. Here, we describe a three-dimensional (3D) bioreactor system where cancer cells are grown in Matrigel in modified six-well plates. Oxygen is delivered to the cultures through a polydimethylsiloxane (PDMS) membrane at the bottom of the wells, with microfabricated PDMS pillars to control oxygen delivery. Read More

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http://dx.doi.org/10.1002/jcp.28665DOI Listing

Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.

Endocrine 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: This study aimed to investigate independent relationships of daily non-exercise life activity and leisure-time exercise volume and intensity with the prevalence of metabolic syndrome and its traits in Japanese adults.

Methods: Data of 24,625 eligible subjects (12,709 men, 11,916 women) who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study were analyzed. Information about lifestyle characteristics was obtained from a questionnaire. Read More

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http://dx.doi.org/10.1007/s12020-019-01926-9DOI Listing

Maintaining Harmony: How Religion and Culture are Interwoven in Managing Daily Diabetes Self-Care.

J Relig Health 2019 Apr 22. Epub 2019 Apr 22.

School of Health and Society, University of Salford, Manchester, UK.

The lingering culture among Javanese people cannot be separated from religion, influencing how they perceive any factors that might play a role in managing any health condition. This present study aimed in exploring the perceptions and experiences of religion and culture in performing daily self-care among Javanese Muslim with type 2 diabetes. A qualitative study with thematic content analysis method utilizing in-depth semi-structured interviews was undertaken to explore the perceptions and experiences of Javanese Muslim with diabetes managing their daily self-care activity. Read More

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http://dx.doi.org/10.1007/s10943-019-00819-5DOI Listing

High-fat diet promotes adrenaline production by visceral adipocytes.

Eur J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Alameda Prof Hernâni Monteiro, 4200-319, Porto, Portugal.

Purpose: Catecholamines (CA) play a major role in metabolism and immune response. Recent reports showing adipose tissue can synthetize CA enlighten new roles for these amines in obesity. This study aimed to evaluate the expression of both tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) and CA content along preadipocytes differentiation, under normal and obesigenic conditions. Read More

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http://link.springer.com/10.1007/s00394-019-01971-0
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http://dx.doi.org/10.1007/s00394-019-01971-0DOI Listing
April 2019
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Potential for Molecular Testing for Group A Streptococcus to Improve Diagnosis and Management in a High-Risk Population: A Prospective Study.

Open Forum Infect Dis 2019 Apr 26;6(4):ofz097. Epub 2019 Feb 26.

Menzies School of Health Research, Charles Darwin University.

Background: In high-burden settings, guidelines recommend antibiotic treatment for all suspected group A (GAS) infections to prevent rheumatic fever and poststreptococcal glomerulonephritis. Highly sensitive rapid GAS tests could reduce unnecessary antibiotic use in these settings.

Methods: This was a prospective study of the Xpert Xpress Strep A (Cepheid) molecular test compared with culture of throat swab samples collected at a referral hospital in northern Australia. Read More

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http://dx.doi.org/10.1093/ofid/ofz097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469435PMC

Abdominal Ultrasound for the Diagnosis of Tuberculosis Among Human Immunodeficiency Virus-Positive Inpatients With World Health Organization Danger Signs.

Open Forum Infect Dis 2019 Apr 7;6(4):ofz094. Epub 2019 Apr 7.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa.

Background: Studies of the value of abdominal ultrasound for diagnosing human immunodeficiency virus (HIV)-associated tuberculosis have major limitations.

Methods: We conducted a prospective study of HIV-positive inpatients with cough and World Health Organization danger signs. The reference standard was positive culture from any site. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz09
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http://dx.doi.org/10.1093/ofid/ofz094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469434PMC
April 2019
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Balancing Overuse and Underuse in the Iranian Healthcare System: A Force Field Theory Analysis.

Ethiop J Health Sci 2019 Mar;29(2):231-238

Iranian Center of Excellence in Health Management, Department of Health Services Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Overuse and underuse of healthcare services occure within population, organizations and even patients around the world. Producing a balance between these two can increase efficiency, service quality and patient satisfaction. It also decrease extra costs. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460443PMC

Enteropathogens in Under-Five Children with Diarrhea in Health Facilities of Debre Berhan Town, North Shoa, Ethiopia.

Ethiop J Health Sci 2019 Mar;29(2):203-214

Department of Medicine, Medical Microbiology Unit, Debre Berhan University, Ethiopia.

Background: Diarrheal disease is a major cause of mortality and morbidity for under-five children in Ethiopia. The purpose of this study was to investigate the behavioral and socioeconomic risk factors, etiology, and drug susceptibility of bacteria isolated from under-five children with acute diarrhea who were treated at Debre Berhan Referral Hospital or Health Center in Ethiopia.

Methods: A health facility based cross-sectional study design was used to investigate enteropathogens from 163 under-five children with acute diarrhea. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460452PMC
March 2019
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Culture, Ageing and the Construction of Pain.

Geriatrics (Basel) 2018 Jul 9;3(3). Epub 2018 Jul 9.

Faculty of Health Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, Essex, CM1 1SQ, UK.

In this paper, the authors seek to discuss some of the complexities involved in cross-cultural working in relation to the communication and management of pain in older people. Specifically, the paper addresses the culture construction of ageing and how pain is often constructed as a natural part of ageing. The authors also suggest that with the rise of the ideology of active-ageing, many older people who are disabled or living in chronic pain, may feel a moral imperative to hide pain and ill-health. Read More

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http://dx.doi.org/10.3390/geriatrics3030040DOI Listing

Organizational Readiness to Implement the Chronic Disease Self-Management Program in Dialysis Facilities.

Geriatrics (Basel) 2018 Jun 14;3(2). Epub 2018 Jun 14.

Emory University, School of Medicine, Atlanta, GA 30322, USA.

A gap exists between the development and uptake of evidence-based health promotion programs in health care settings. One reason for this gap is lack of attention to organizational readiness. The objective of this study was to assess organizational readiness to implement the Chronic Disease Self-Management Program in dialysis facilities. Read More

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http://dx.doi.org/10.3390/geriatrics3020031DOI Listing

The Role of Religion, Spirituality and/or Belief in Positive Ageing for Older Adults.

Geriatrics (Basel) 2018 Jun 8;3(2). Epub 2018 Jun 8.

Faculty of Health, Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, UK.

(1) Background: The concept of positive ageing is gaining recognition as an approach to better understand the lives of older adults throughout the world. Positive ageing encompasses the various ways in which older adults approach life challenges associated with ageing and how certain approaches allow older adults to age in a more positive way. This paper makes a contribution to the field by examining the role of religion, spirituality and/or belief in relation to positive ageing; (2) Methods: Qualitative focus groups with 14 older adults living in West London explored the role and importance religion, spirituality and/or belief held in their everyday lives and how this could be incorporated into the idea of positive ageing; (3) Results: Religion, spirituality and/or belief were found to play a number of roles in the everyday lives of the older adults, including being a source of strength, comfort and hope in difficult times and bringing about a sense of community and belonging; (4) Conclusion: This paper argues that religion, spirituality and/or belief should be included within positive ageing literature and be viewed as a type of support (amongst multiple others) that helps older adults to live positive lives despite the many challenges of ageing. Read More

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http://www.mdpi.com/2308-3417/3/2/28
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http://dx.doi.org/10.3390/geriatrics3020028DOI Listing
June 2018
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Fibroblast and keratinocyte crosstalk: the effect of a poly(tri[ethylene glycol] ethyl ether methacrylate) thermoresponsive surface on short-term co-culture.

Eur J Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Katowice, Medyków 18 str, Bldg. C-1, 40-752 Katowice,, Centre for Burn Treatment in Siemianowice Śląskie, Siemianowice Śląskie Jana Pawla II.

The treatment of difficult-to-treat wounds can be challenging. Although a number of approaches have been investigated, the healing process may be slow and unsatisfactory. An alternative approach is the use of a continuous sheet of skin cells applied over a wound which may improve cell implantation and patient recovery. Read More

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http://dx.doi.org/10.1684/ejd.2019.3561DOI Listing
April 2019
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