5,888 results match your criteria Cryptosporidiosis


Past and future trends of Cryptosporidium in vitro research.

Exp Parasitol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Molecular and Evolutionary Parasitology, RAPID Group, School of Biosciences, University of Kent, Canterbury, Kent, UK; School of Biosciences, University of Kent, Canterbury, Kent, UK. Electronic address:

Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis. Read More

View Article
December 2018
1 Read

Identification of novel vaccine candidates against cryptosporidiosis of neonatal bovines by reverse vaccinology.

Vet Parasitol 2018 Dec 12;264:74-78. Epub 2018 Nov 12.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Argentina; Facultad de Ciencias exactas, químicas y naturales (FCEQN), Universidad de Morón, Morón, Argentina. Electronic address:

The apicomplexan protozoan Cryptosporidium parvum is an important causative agent of diarrhea of neonatal bovines. Vaccination has been proposed as an advantageous strategy against cryptosporidiosis of calves since besides protection against disease it has also the potential to prevent dissemination of infective oocysts into the environment. Antigens anchored to the parasite surface via glycosylphosphatidylinositol (GPI) are implicated in host cell attachment and invasion and represent promising vaccine candidates. Read More

View Article
December 2018

Disinfection with hydrated lime may help manage cryptosporidiosis in calves.

Vet Parasitol 2018 Dec 10;264:58-63. Epub 2018 Nov 10.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054 SE-750 07 Uppsala, Sweden.

Diarrhea is common in young calves and is often caused by Cryptosporidium parvum infection. The aim of this study was to investigate if disinfection of calf pens with hydrated lime would reduce contamination of C. parvum oocysts and improve calf health in herds with C. Read More

View Article
December 2018

First Cryptosporidium outbreak in Hungary, linked to a treated recreational water venue in 2015.

Epidemiol Infect 2018 Dec 3:1-6. Epub 2018 Dec 3.

Cryptosporidium Reference Unit, Public Health Wales Microbiology and Health Protection, Singleton Hospital,Swansea,UK.

In June 2015, an outbreak of cryptosporidiosis with 35 cases (23 probable and 12 laboratory-confirmed) occurred among 191 attendees of a residential rehabilitation holiday for paediatric organ transplant patients (n = 49) and their families at a hotel in Somogy county, Hungary. The overall attack rate was 18%. Most of the cases were transplanted children who experienced severe acute disease and required adjustment to their tacrolimus immunosuppression. Read More

View Article
December 2018

Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting.

Am J Trop Med Hyg 2018 Nov 19. Epub 2018 Nov 19.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

Cryptosporidiosis is commonly described as a cause of gastroenteritis syndrome in the organ transplant population, mainly in high-prevalence settings, with stool microscopy as the predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging. We describe a case of a renal transplant recipient with cryptosporidiosis confirmed by the stool FilmArray gastrointestinal panel (GIP) nucleic acid-based assay and stool microscopy, describe our institutional experience in diagnosing cryptosporidiosis in a low-prevalence setting, and review the available literature on management of this condition in the organ transplant population. Read More

View Article
November 2018
7 Reads

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.

J Enzyme Inhib Med Chem 2019 Dec;34(1):171-178

a Division of Applied Bioscience, Graduate School of Agriculture , Hokkaido University , Sapporo , Japan.

Inosine 5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the present study, we established a luciferase-based high-throughput screening system to identify IMPDH inhibitors from our chemical library of known bioactive small molecules. Read More

View Article
December 2019
3 Reads

A spatial analysis of giardiasis and cryptosporidiosis in relation to public water supply distribution in North West England.

Spat Spatiotemporal Epidemiol 2018 Nov 13;27:61-70. Epub 2018 Oct 13.

CHICAS, Lancaster Medical School, Lancaster University, LA1 4YW United Kingdom.

Giardia and Cryptosporidium are both waterborne parasites and leading causes of gastroenteritis. Although specimens from diarrhoeic patients are routinely examined for Cryptosporidium, they are often not examined for Giardia so many cases go undiagnosed. Since 2002, all faecal specimens in Central Lancashire have been tested for infection with Giardia and Cryptosporidium. Read More

View Article
November 2018
12 Reads

Risk factors for sporadic cryptosporidiosis in the Netherlands: Analysis of a three-year population based case-control study coupled with genotyping, 2013-2016.

J Infect Dis 2018 Nov 3. Epub 2018 Nov 3.

National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.

Background: In 2012, cryptosporidiosis cases increased in the Netherlands, but no single source was identified. In April 2013, we began a three year population based case-control study, coupled with genotyping, to identify risk factors for sporadic cryptosporidiosis.

Methods: Cryptosporidium cases were laboratory confirmed (microscopy or PCR), followed by C. Read More

View Article
November 2018
2 Reads

Curcumin: A promising treatment for Cryptosporidium parvum infection in immunosuppressed BALB/c mice.

Exp Parasitol 2018 Dec 29;195:59-65. Epub 2018 Oct 29.

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Members of the genus Cryptosporidium are frequent protozoan pathogens in humans and a wide range of animals. There is no consistently effective treatment against cryptosporidiosis, especially in immunodeficient patients. The present study was carried out to study the therapeutic effects of curcumin against cryptosporidiosis in immunosuppressed BALB/c mice. Read More

View Article
December 2018
1 Read

Socio-Behavioral Risk Factors Associated with Cryptosporidiosis in HIV/AIDS Patients Visiting the HIV Referral Clinic at Cape Coast Teaching Hospital, Ghana.

Open AIDS J 2018 12;12:106-116. Epub 2018 Sep 12.

Department of Biomedical Sciences, School of Allied Health Sciences, Collage of Health and Allied Science, University of Cape Coast, Cape Coast, Ghana.

Objective: To identify the socio-behavioral risk factors associated with cryptosporidiosis among HIV/AIDS patients with chronic diarrhea symptoms visiting the HIV referral clinic at Cape Coast Teaching Hospital, Ghana.

Methods: A cross-sectional study was conducted among 50 HIV/AIDS patients with recurrent diarrhea. Questionnaires were administered to collect social and behavioral risk factors associated with and other opportunistic protozoan parasitic infections in HIV patients. Read More

View Article
September 2018
7 Reads

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Oct 16. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

View Article
October 2018
5 Reads

Advantage of parenteral nutrition for diarrheic calves.

J Vet Med Sci 2018 Oct 8. Epub 2018 Oct 8.

School of Veterinary Medicine, Rakuno Gakuen University.

This study assessed the advantages of dextrose and amino acid mixture solution as parenteral nutrition (PN) therapy for diarrheic calves. Thirty diarrheic calves were randomly assigned to receive PN (PN group, n=15) or only dextrose solution (Dex group, n=15). The treatment period for the PN group (4. Read More

View Article
October 2018
1 Read

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have Activity against Cryptosporidium.

Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.

species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes infection severity in a malnourished mouse model despite a lack of direct anticryptosporidial activity. Read More

View Article
December 2018
6 Reads

Faecal contamination in public pools in Barcelona province: Cryptosporidium spp. and bacterial indicators.

J Water Health 2018 Oct;16(5):762-772

Section of Parasitology, Department of Biology, Healthcare and the Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII s/n, Barcelona, Spain.

A study was conducted of the occurrence of Cryptosporidium in indoor heated public swimming pools and of three bacterial indicators (Escherichia coli, faecal enterococci and Clostridium perfringens) on pool surrounds. Although all examined pools adhered strictly to the Spanish regulations, the influence of several parameters related to water conditions, pool structure, users and location on the presence of protozoa and bacteria was analysed. Cryptosporidium was detected in 18. Read More

View Article
October 2018
1 Read

Sick leave due to diarrhea caused by contamination of drinking water supply with Cryptosporidium hominis in Sweden: a retrospective study.

J Water Health 2018 Oct;16(5):704-710

Department of Public Health and Clinical Medicine, Unit of Clinical Research Center - Östersund, Umeå University, Umeå, Sweden E-mail:

We investigated sick leave from work, studies, preschool, and kindergarten occurring between 1 November 2010 and 31 January 2011 and associated with a waterborne outbreak of diarrhea caused by Cryptosporidium hominis in late November 2010 in Östersund, Sweden with 45.2% of 60,000 residents being symptomatic. A questionnaire defining acute watery diarrhoea and/or ≥3 diarrhea episodes/day as cryptosporidiosis was sent to 1,508 residents in late January 2011 (response rate 69. Read More

View Article
October 2018
1 Read

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.

Proc Natl Acad Sci U S A 2018 10 3;115(42):10750-10755. Epub 2018 Oct 3.

California Institute for Biomedical Research, La Jolla, CA 92037;

The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic utility in indications outside those originally targeted, especially neglected tropical diseases. This practice of "drug repurposing" has become commonplace in academic and other nonprofit drug-discovery efforts, with the appeal that significantly less time and resources are required to advance a candidate into the clinic. Here, we report a comprehensive open-access, drug repositioning screening set of 12,000 compounds (termed ReFRAME; Repurposing, Focused Rescue, and Accelerated Medchem) that was assembled by combining three widely used commercial drug competitive intelligence databases (Clarivate Integrity, GVK Excelra GoStar, and Citeline Pharmaprojects), together with extensive patent mining of small molecules that have been dosed in humans. Read More

View Article
October 2018
3 Reads

Cryptosporidium spp. CP15 and CSL protein-derived synthetic peptides' immunogenicity and in vitro seroneutralisation capability.

Vaccine 2018 Oct 26;36(45):6703-6710. Epub 2018 Sep 26.

University of Zaragoza, Animal Pathology Department, Veterinary Sciences Faculty, Spain.

Cryptosporidium spp. is a zoonotic intracellular protozoan and a significant cause of diarrhoea in humans and animals worldwide. This parasite can cause high morbidity in immunocompromised people and children in developing countries, livestock being the main reservoir. Read More

View Article
October 2018
5 Reads

A canine model of experimental infection with Cryptosporidium canis.

Exp Parasitol 2018 Dec 25;195:19-23. Epub 2018 Sep 25.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China; International Joint Research Laboratory for Zoonotic Diseases of Henan, Zhengzhou, China. Electronic address:

Cryptosporidium is a genus of protozoal parasites that affects the gastrointestinal epithelium of a variety of hosts. Several models of experimental infection have been described to study the susceptibility, infectivity and pathogenicity among different Cryptosporidium species and isolates. This study aimed to establish an experimental infection of Cryptodporidium canis in canids. Read More

View Article
December 2018
1 Read
1.860 Impact Factor

In-silico screening of small molecule inhibitors against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum.

Comput Biol Chem 2018 Dec 8;77:44-51. Epub 2018 Sep 8.

Department of Food Science and Technology, Chonbuk National University, Jeonju 561756, South Korea. Electronic address:

Cryptosporidium parvum is a protozoan parasite which causes waterborne diseases known as Cryptosporidiosis. It is an acute enteric diarrheal disease being severe in the case of immunocompromised individuals and children. C. Read More

View Article
December 2018
1 Read

Molecular and histopathological features of Cryptosporidium ubiquitum infection in imported chinchillas Chinchilla lanigera in Japan.

Parasitol Int 2019 Feb 19;68(1):9-13. Epub 2018 Sep 19.

Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan. Electronic address:

Long-tailed chinchillas Chinchilla lanigera are popular rodent species kept both in households, where they are hand-raised as pets, and in zoological facilities. From January 2016 to February 2017, 13 juvenile chinchillas from five facilities in Japan were diagnosed with cryptosporidiosis at the animal hospital. Eight of the cases were fatal. Read More

View Article
February 2019
4 Reads

Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice.

Exp Parasitol 2018 Nov 17;194:1-8. Epub 2018 Sep 17.

UMR BIPAR, Ecole Nationale Vétérinaire d'Alfort, ANSES, INRA, Université Paris-Est, Maisons-Alfort, F-94700, France. Electronic address:

Cryptosporidiosis is a zoonotic disease caused by species in the genus Cryptosporidium. In young ruminants, Cryptosporidium parvum causes economically significant disease with mild to severe clinical signs and occasional death. The typical clinical course in animals aged 1-3 weeks old is acute diarrhoea. Read More

View Article
November 2018
1 Read

Revisiting the infectivity and pathogenicity of Cryptosporidium avium provides new information on parasitic sites within the host.

Parasit Vectors 2018 Sep 19;11(1):514. Epub 2018 Sep 19.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China.

Background: Cryptosporidium spp. are protozoans that cause diarrheal illness in humans and animals, including birds, worldwide. The present study was aimed to revisit the infectivity and pathogenicity of C. Read More

View Article
September 2018
1 Read
3.430 Impact Factor

Recent Breakthroughs and Ongoing Limitations in Research.

F1000Res 2018 3;7. Epub 2018 Sep 3.

Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, 02111, USA.

The intestinal apicomplexan parasite is a major cause of diarrheal disease in humans worldwide. However, treatment options are severely limited. The search for novel interventions is imperative, yet there are several challenges to drug development, including intractability of the parasite and limited technical tools to study it. Read More

View Article
September 2018
1 Read

The Action of the Hexokinase Inhibitor 2-deoxy-d-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs.

J Eukaryot Microbiol 2018 Sep 17. Epub 2018 Sep 17.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, 77843-4467.

Cryptosporidium parvum is one of the major species causing mild to severe cryptosporidiosis in humans and animals. We have previously observed that 2-deoxy-d-glucose (2DG) could inhibit both the enzyme activity of C. parvum hexokinase (CpHK) and the parasite growth in vitro. Read More

View Article
September 2018
2 Reads

Genotypic characterization of Cryptosporidium species in humans and peri-domestic animals in Ekiti and Oyo State, Nigeria.

J Parasitol 2018 Sep 12. Epub 2018 Sep 12.

† Tufts University Cummings School of Veterinary Medicine Tufts University Cummings School of Veterinary Medicine.

Cryptosporidiosis is one of the leading causes of diarrhea in humans and several vertebrates species. Because surveys of Cryptosporidium genotypes from animals and humans living in the same region are rare, our understanding of the importance of zoonotic transmission in the epidemiology of cryptosporidiosis remains superficial. PCR was used to amplify a portion of the Cryptosporidium 18S small subunit ribosomal RNA gene from fecal DNA from humans and livestock living in Ekiti and Oyo state, Nigeria. Read More

View Article
September 2018
23 Reads
1.260 Impact Factor

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease.

Authors:
John E Burke

Mol Cell 2018 Sep;71(5):653-673

Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, V8W 2Y2, Canada. Electronic address:

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's decision to grow, move, divide, and die. Because of this, kinases that phosphorylate phosphoinositide lipids are critically involved in myriad essential functions including growth, development, and membrane trafficking. The misregulation of phosphoinositide kinases is critical in human diseases, including cancer, primary immunodeficiencies, and developmental disorders. Read More

View Article
September 2018
6 Reads

Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households.

Clin Infect Dis 2018 Sep 6. Epub 2018 Sep 6.

Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.

Background: Cryptosporidium is a leading contributor to diarrheal morbidity and mortality in under-5 children worldwide. As there is no vaccine and no effective drug therapy in young children for this infection, preventing infection is critical. We undertook a pilot case-control study to define the extent of person-to-person transmission of cryptosporidiosis within an urban and a rural community in Bangladesh. Read More

View Article
September 2018
4 Reads

[Cryptosporidiosis and "One Health"].

Rev Salud Publica (Bogota) 2018 Jan-Feb;20(1):138-143

JC: MV. M. Sc., Ph. D. Laboratorio de Parasitología Veterinaria, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia. Bogotá, Colombia.

Cryptosporidiosis is a diarrheal disease (zoonotic) caused by the parasite Cryptosporidium, which infects the intestine. It occurs in humans and in different pets, farm and wild animals. Its role is underestimated and little is known about its epidemiology, due to the low interest it draws and the limited availability of diagnostic methods. Read More

View Article
July 2017
1 Read

Probiotic Product Enhances Susceptibility of Mice to Cryptosporidiosis.

Appl Environ Microbiol 2018 Nov 17;84(21). Epub 2018 Oct 17.

Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA

Cryptosporidiosis, a leading cause of diarrhea among infants, is caused by apicomplexan parasites classified in the genus The lack of effective drugs is motivating research to develop alternative treatments. With this aim, the impact of probiotics on the course of cryptosporidiosis was investigated. The native intestinal microbiota of specific pathogen-free immunosuppressed mice was initially depleted with orally administered antibiotics. Read More

View Article
November 2018
3 Reads

infection in calves and the environment in Asembo, Western Kenya: 2015.

Pan Afr Med J 2017 4;28(Suppl 1). Epub 2017 Nov 4.

Paul G. Allen School for Global Animal Health, Washington State University, USA.

Introduction: species, a zoonotic enteric coccidian parasite, is among the leading causes of diarrhea in children. We evaluated the prevalence of infections in calves, factors associated with calf infection, environmental contamination of manure by and factors that expose humans to zoonotic transmission in Asembo.

Methods: in a cross-sectional study conducted from January to July 2015, we collected fecal specimens from 350 randomly selected calves aged ≤ 6 months old and 187 manure samples from the same farms. Read More

View Article
September 2018
8 Reads

Limitations in the screening of potentially anti-cryptosporidial agents using laboratory rodents with gastric cryptosporidiosis.

Folia Parasitol (Praha) 2018 Aug 16;65. Epub 2018 Aug 16.

Department of Botany and Zoology, Faculty of Science, Masaryk University, Brno, Czech Republic.

The emergence of cryptosporidiosis, a zoonotic disease of the gastrointestinal and respiratory tract caused by Cryptosporidium Tyzzer, 1907, triggered numerous screening studies of various compounds for potential anti-cryptosporidial activity, the majority of which proved ineffective. Extracts of Indonesian plants, Piper betle and Diospyros sumatrana, were tested for potential anti-cryptosporidial activity using Mastomys coucha (Smith), experimentally inoculated with Cryptosporidium proliferans Kváč, Havrdová, Hlásková, Daňková, Kanděra, Ježková, Vítovec, Sak, Ortega, Xiao, Modrý, Chelladurai, Prantlová et McEvoy, 2016. None of the plant extracts tested showed significant activity against cryptosporidia; however, the results indicate that the following issues should be addressed in similar experimental studies. Read More

View Article
August 2018
9 Reads
1.210 Impact Factor

Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial.

Trials 2018 Aug 23;19(1):456. Epub 2018 Aug 23.

University of Malawi College of Medicine, Blantyre, Malawi.

Background: Cryptosporidium infection and diarrhea (cryptosporidiosis) is a life-threatening infection in persons with HIV and also in children of 6-18 months of age in the developing world. To date, only nitazoxanide is licensed for treatment of cryptosporidiosis, and only in persons after the first year of life and with healthy immune systems. Clofazimine (CFZ: Lamprene®), an established drug that has been used for leprosy for more than 50 years, recently has been described as effective against Cryptosporidium in vitro and in mouse infections. Read More

View Article
August 2018
5 Reads

Parasitic infections of the gut in children.

Paediatr Int Child Health 2018 Aug 22:1-8. Epub 2018 Aug 22.

a Tropical Gastroenterology and Nutrition group , University of Zambia School of Medicine , Lusaka , Zambia.

Parasitic infections of the gut have major implications for child health, but many questions remain unanswered. Protozoal parasites, especially cryptosporidiosis and giardiasis, cause diarrhoea and contribute to impaired growth, neurocognitive development and mortality. Entamoeba histolytica causes dysentery and may have more subtle effects on child growth. Read More

View Article
August 2018
7 Reads

Rapid diagnostic tests relying on antigen detection from stool as an efficient point of care testing strategy for giardiasis and cryptosporidiosis? Evaluation of a new immunochromatographic duplex assay.

Diagn Microbiol Infect Dis 2018 Jul 25. Epub 2018 Jul 25.

Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU Nantes. Electronic address:

Microscopy is the gold standard for the diagnosis of gastrointestinal parasites but is time-consuming and dependent on operator skills. Rapid diagnostic tests represent alternative methods but most evaluations have been conducted on a limited number of samples preventing their implementation in the clinical setting. We evaluated a new CE-IVD marked immunochromatographic assay (Crypto/Giardia K-SeT®, Coris Bioconcept) for the detection of G. Read More

View Article
July 2018
1 Read

Widespread occurrence of Cryptosporidium infections in patients with HIV/AIDS: Epidemiology, clinical feature, diagnosis, and therapy.

Acta Trop 2018 Nov 15;187:257-263. Epub 2018 Aug 15.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, PR China. Electronic address:

Cryptosporidium infection is a serious threat for HIV/AIDS patients, causing severe diarrhea and even death. The overall prevalence of Cryptosporidium in HIV/AIDS patients was calculated as approximately 8.69% (7,799/89,724), with higher prevalence observed in individuals with diarrhea, individuals with low CD4 T-lymphocyte counts, and antiretroviral therapy-naïve individuals. Read More

View Article
November 2018
11 Reads

Seroprevalence of Cryptosporidium parvum and Neospora caninum in cattle in the southern Kyushu region of Japan.

Parasitol Int 2018 Dec 12;67(6):763-767. Epub 2018 Aug 12.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan.

Cryptosporidium parvum and Neospora caninum are common parasites in domesticated cattle worldwide, including in Japan. We carried out a serological survey to detect C. parvum and N. Read More

View Article
December 2018

Human cryptosporidiosis in immunodeficient patients in France (2015-2017).

Exp Parasitol 2018 Sep 11;192:108-112. Epub 2018 Aug 11.

University Hospital of Dijon, France.

Cryptosporidiosis is a common disease in children and immunodeficient individuals. In 2006, a national network was set up on the surveillance of human cryptosporidiosis in France. Since January 2015, the 41 tertiary care hospitals and the 3 private laboratories of the French National Network on the surveillance of human cryptosporidiosis have been able to declare confirmed cases of cryptosporidiosis online. Read More

View Article
September 2018

Treatment interventions for diarrhoea in HIV-infected and HIV-exposed children: a systematic review.

Pan Afr Med J 2018 9;29:208. Epub 2018 Apr 9.

Global Health Sciences, University of California, San Francisco, San Francisco, California, USA.

Introduction: Seventy percent of an estimated 10 million children less than five years of age in developing countries die each year of acute respiratory infections, diarrhoea, measles, malaria, malnutrition or a combination of these conditions. Children living with Human immunodeficiency virus (HIV) are at risk of diarrhoea because of drug interactions with antiretroviral therapy and bottle feeding. This may be aggravated by malnutrition and other infectious diseases which are frequent in children living with HIV. Read More

View Article
August 2018
3 Reads

Molecular epidemiology of Cryptosporidium spp. in calves in Estonia: high prevalence of Cryptosporidium parvum shedding and 10 subtypes identified.

Parasitology 2018 Aug 8:1-7. Epub 2018 Aug 8.

Department of Veterinary and Animal Sciences,University of Copenhagen,Grønnegårdsvej 15, 1870 Frederiksberg C,Denmark.

We investigated the molecular epidemiology of Cryptosporidium spp. in Estonia by testing fecal samples from 486 calves aged <2 months, raised on 53 cattle farms, for the presence of Cryptosporidium DNA. The parasites were identified and characterized by sequencing of the 18S rRNA gene and of the 60 kDa glycoprotein (gp60) gene. Read More

View Article
August 2018
1 Read

Intestinal cryptosporidiosis in renal transplant recipients: Prevalence, species detection and comparative evaluation of SSU rRNA and oocyst wall protein genes.

Indian J Med Microbiol 2018 Apr-Jun;36(2):247-250

Department of Gastroenterology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Context: Cryptosporidiosis is intestinal opportunistic infection commonly occurring in immunocompromised patients including renal transplant (RT) recipients receiving continuous immunosuppressive therapy. Knowledge about species of Cryptosporidium-infecting RT recipients is necessary to know about mode of its transmission (anthroponotic or zoonotic). Various genes such as small subunit rRNA (SSU rRNA) and Cryptosporidium oocyst wall protein (COWP) genes may help in species identification though their sensitivity and specificity are highly variable. Read More

View Article
August 2018
4 Reads

Health workers' knowledge of zoonotic diseases in an endemic region of Western Uganda.

Zoonoses Public Health 2018 11 3;65(7):850-858. Epub 2018 Aug 3.

Department of Biosecurity, Ecosystem Health and Veterinary Public Health College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.

Many factors, including lack of knowledge, influence diagnosis and reporting of disease in Sub-Saharan Africa. Health Care workers (HCWs) are in constant interaction with communities and play an important role in the prevention, diagnosis and treatment of infectious diseases, including zoonoses. We determined knowledge of HCWs regarding cause, vector, transmission, diagnosis and clinical symptoms of five zoonotic diseases: anthrax, brucellosis, rabies as well as Ebola and marburg haemorrhagic fevers in endemic western Uganda. Read More

View Article
November 2018
5 Reads

A systematic review on modelling approaches for economic losses studies caused by parasites and their associated diseases in cattle.

Parasitology 2018 Aug 2:1-13. Epub 2018 Aug 2.

Laboratoire de Parasitologie,École Nationale de Médecine Vétérinaire, Univ. Manouba,2020 Sidi Thabet,Tunisia.

Parasites reside inside or outside their hosts and get host nutrition and blood. Here, we have emphasized economic losses in cattle caused by parasitic diseases due to ecto- and endo- parasites (flies, ticks, mites and helminths). We have outlined different methods/models including economic evaluation techniques and dynamic analysis as a major class, used for the calculation of economic losses caused by parasites in cattle. Read More

View Article
August 2018
2 Reads

Age patterns of Cryptosporidium species and Giardia duodenalis in dairy calves in Egypt.

Parasitol Int 2018 Dec 25;67(6):736-741. Epub 2018 Jul 25.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Little is known of the occurrence and age patterns of species/genotypes and subtypes of Cryptosporidium spp. and Giardia duodenalis in calves in Egypt. In this study, 248 fecal specimens were collected from dairy calves aged 1 day to 6 months on eight farms in three provinces during March 2015 to April 2016. Read More

View Article
December 2018
5 Reads
1 Citation
2.110 Impact Factor

Attenuation of Intestinal Epithelial Cell Migration During Cryptosporidium parvum Infection Involves Parasite Cdg7_FLc_1030 RNA-Mediated Induction and Release of Dickkopf-1.

J Infect Dis 2018 Sep;218(8):1336-1347

Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska.

Intestinal infection by Cryptosporidium is known to cause epithelial cell migration disorder but the underlying mechanisms are unclear. Previous studies demonstrated that a panel of parasite RNA transcripts of low protein-coding potential are delivered into infected epithelial cells. Using multiple models of intestinal cryptosporidiosis, we report here that C. Read More

View Article
September 2018
10 Reads

Cryopreservation of infectious Cryptosporidium parvum oocysts.

Nat Commun 2018 07 23;9(1):2883. Epub 2018 Jul 23.

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, 01536, USA.

Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we report a method to cryopreserve C. Read More

View Article
July 2018
5 Reads

The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis.

Hum Vaccin Immunother 2018 Aug 27:1-8. Epub 2018 Aug 27.

a Department of Infectious Disease and Global Health , Cummings School of Veterinary Medicine at Tufts University , North Grafton, MA , USA.

Cryptosporidium spp. are ranked as the second leading pathogens causing life-threatening diarrhea in children under 2 years of age. Although Cryptosporidium hominis causes three quarters of the cases of cryptosporidiosis, studies on C. Read More

View Article
August 2018
4 Reads

Molecular and histopathological characterization of Cryptosporidium and Eimeria species in bats in Japan.

J Vet Med Sci 2018 Sep 16;80(9):1395-1399. Epub 2018 Jul 16.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

Bats are potential reservoirs of Cryptosporidium and Eimeria. The genus Cryptosporidium infects various vertebrates and causes a diarrheal disease known as cryptosporidiosis. Many epidemiological studies in wild animals have been performed; however, most of them relied on only PCR-based detection because of the difficulty of performing pathological analyses. Read More

View Article
September 2018
1 Read

Molecular characterisation and risk factor analysis of Cryptosporidium spp. in calves from Italy.

Parasitol Res 2018 Jul 14. Epub 2018 Jul 14.

Laboratory of Parasitology, Veterinary Teaching Hospital, Department of Veterinary Medicine, University of Sassari, Sassari, Italy.

To provide up-to-date information on the occurrence of Cryptosporidium in pre-weaned calves from Sardinia (Italy), the species implicated and their zoonotic potential, 147 faecal samples from 22 cattle herds were microscopically examined for Cryptosporidium oocysts; positive isolates were molecularly characterised. A questionnaire was developed to identify risk factors for Cryptosporidium infection. Overall, the percentage of positive calves and farms was 38. Read More

View Article
July 2018
4 Reads

Sheep as a Potential Source of Zoonotic Cryptosporidiosis in China.

Appl Environ Microbiol 2018 Sep 31;84(18). Epub 2018 Aug 31.

Key Laboratory of Animal Parasitology of Ministry of Agriculture, Laboratory of Quality and Safety Risk Assessment for Animal Products on Biohazards (Shanghai) of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

In this study, we assessed the prevalence and genetic characteristics of in sheep from 10 provinces in China. Fecal samples from 1,035 sheep originating from 16 farms were collected, and 295 (28.5%) were found to be positive by nested PCR. Read More

View Article
September 2018
19 Reads

Novel treatment strategies and drugs in development for cryptosporidiosis.

Expert Rev Anti Infect Ther 2018 Aug 17;16(8):655-661. Epub 2018 Jul 17.

b Infectious Diseases Division, Department of Internal Medicine , University of Texas Medical Branch , Galveston , Texas , USA.

Introduction: Cryptosporidium is a protozoan pathogen that can cause diarrheal disease in healthy and immunosuppressed individuals, worldwide. Recent studies have highlighted the impact of cryptosporidiosis on children in resource-limited countries. Nitazoxanide is the only Food and Drug Administration approved treatment, but it is not consistently effective therapy for cryptosporidiosis in the most vulnerable populations. Read More

View Article
August 2018
3 Reads