5,971 results match your criteria Cryptosporidiosis


Local weather, flooding history and childhood diarrhoea caused by the parasite Cryptosporidium spp.: A systematic review and meta-analysis.

Sci Total Environ 2019 Mar 28;674:300-306. Epub 2019 Mar 28.

National Centre for Epidemiology and Population Health, Building 62, Research School of Population Health, Australian National University, Acton, Canberra 2602, Australia.

Scientists have long predicted the impacts of climate-related infectious disease emergence. Yet, the combined effect of local socioeconomic and demographic factors and weather variation on child health is poorly understood. With a focus on childhood diarrhoea caused by the parasite Cryptosporidium spp. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.365DOI Listing

NMR metabolomics reveals effects of infections on host cell metabolome.

Gut Pathog 2019 3;11:13. Epub 2019 Apr 3.

1Laboratory of Molecular & Evolutionary Parasitology, RAPID Group, School of Biosciences, University of Kent, Canterbury, UK.

Background: is an important gut microbe whose contributions towards infant and immunocompromise patient mortality rates are steadily increasing. Over the last decade, we have seen the development of various tools and methods for studying infection and its interactions with their hosts. One area that is sorely overlooked is the effect infection has on host metabolic processes. Read More

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https://gutpathogens.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13099-019-0293-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446323PMC
April 2019
1 Read

Cryptosporidium proventriculi sp. n. (Apicomplexa: Cryptosporidiidae) in Psittaciformes birds.

Eur J Protistol 2019 Mar 26;69:70-87. Epub 2019 Mar 26.

Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, v.v.i., České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, Czech Republic. Electronic address:

Cryptosporidiosis is a common parasitic infection in birds that is caused by more than 25 Cryptosporidium species and genotypes. Many of the genotypes that cause avian cryptosporidiosis are poorly characterized. The genetic and biological characteristics of avian genotype III are described here and these data support the establishment of a new species, Cryptosporidium proventriculi. Read More

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http://dx.doi.org/10.1016/j.ejop.2019.03.001DOI Listing
March 2019
2 Reads

Massive Cryptosporidium infections and chronic diarrhea in HIV-negative patients.

Parasitol Res 2019 Apr 12. Epub 2019 Apr 12.

Department and Clinic of Tropical and Parasitic Diseases, Poznań University of Medical Sciences, Przybyszewskiego Street, 60-355, Poznań, Poland.

Protozoa of the genus Cryptosporidium are common parasites of domestic and wild animals-mammals, birds, reptiles, and fishes. The invasive forms are thick-walled oocysts, which can be present in water supplies, on fruits, vegetables, or in the soil contaminated with feces. In this work, we describe three cases of middle-aged persons with massive Cryptosporidium hominis infection and chronic diarrhea with no immunological abnormalities and no history of previous travels to tropical countries. Read More

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http://dx.doi.org/10.1007/s00436-019-06302-0DOI Listing
April 2019
3 Reads

ApiAP2 Transcription Factors in Apicomplexan Parasites.

Pathogens 2019 Apr 7;8(2). Epub 2019 Apr 7.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany.

Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite and the causative agents of toxoplasmosis () and cryptosporidiosis ( spp.). Apicomplexan parasites can infect one or more hosts, in which they differentiate into several morphologically and metabolically distinct life cycle stages. Read More

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http://dx.doi.org/10.3390/pathogens8020047DOI Listing
April 2019
1 Read

Common variable immunodeficiency syndrome with chronic diarrhoea.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Gastroenterology, Medanta-The Medicity, Gurgaon, India.

Common variable immunodeficiency syndrome (CVID) is a heterogeneous disorder characterised by diminished levels of IgG, IgA and/or IgM, and recurrent bacterial infections. Sinopulmonary infections are most commonly reported followed by gastrointestinal (GI) infections. GI tract represents the largest immune organ with abundance of lymphoid cells, its involvement can manifest variably ranging from asymptomatic involvement to florid symptoms and signs. Read More

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http://dx.doi.org/10.1136/bcr-2018-228240DOI Listing
March 2019
1 Read

Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening.

Bioorg Med Chem Lett 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

Protozoans of the genus Cryptosporidium are the causative agent of the gastrointestinal disease, cryptosporidiosis, which can be fatal in immunocompromised individuals. Cryptosporidium hominis (C. hominis) bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) is an essential enzyme in the folate biosynthesis pathway and a molecular target for inhibitor design. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.03.022DOI Listing

Prevalence of Cryptosporidium spp. in asymptomatic small ruminants in Grenada, West Indies.

Vet Parasitol Reg Stud Reports 2019 Jan 10;15:100262. Epub 2019 Jan 10.

Department of Pathobiology, School of Veterinary Medicine, St. George's University, St. George's, Grenada.

Cryptosporidium spp. is a protozoan parasite that causes enteric infection in a wide range of hosts, including livestock and humans. The aim of this cross-sectional study was to estimate the prevalence of Cryptosporidium spp. Read More

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http://dx.doi.org/10.1016/j.vprsr.2019.100262DOI Listing
January 2019

Protocol standardization for the detection of Giardia cysts and Cryptosporidium oocysts in Mediterranean mussels (Mytilus galloprovincialis).

Int J Food Microbiol 2019 Jun 16;298:31-38. Epub 2019 Mar 16.

Laboratory of Infectious and Parasitic Diseases, Veterinary Research Institute, Hellenic Agricultural Organization - DEMETER, 57001 Thermi, Thessaloniki, Greece. Electronic address:

Marine bivalve shellfish are of public health interest because they can accumulate pollutants in their tissues. As they are usually consumed raw or lightly cooked, they are considered to be a possible source of foodborne infections, including giardiosis and cryptosporidiosis. Although data indicating contamination of shellfish with Giardia cysts and Cryptosporidium oocysts have been published, comparing results from different studies is difficult, as there is no standardized protocol for the detection and quantification of these parasites in mussels, and different researchers have used different analytical approaches. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.03.009DOI Listing
June 2019
1 Read

Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency.

J Clin Immunol 2019 Feb 21;39(2):207-215. Epub 2019 Mar 21.

Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, LMU Munich, Lindwurmstrasse 4, 80337, Munich, Germany.

Inborn errors in interleukin 2 receptor, gamma (IL2RG) perturb signaling of the common gamma chain family cytokines and cause severe combined immunodeficiency (SCID). Here, we report two brothers suffering from chronic cryptosporidiosis, severe diarrhea, and cholangitis. Pan T, B, and NK cell numbers were normal, but immunophenotyping revealed defective B cell differentiation. Read More

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http://dx.doi.org/10.1007/s10875-019-00606-7DOI Listing
February 2019
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 Apr 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage and in cell-culture studies. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019
12 Reads

Piperazine-Derivative MMV665917: an effective drug in the diarrheic piglet model of Cryptosporidium hominis.

J Infect Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA.

Background: Cryptosporidiosis, an enteric protozoon, causes substantial morbidity and mortality associated with diarrhea in children <2 years old in low-to-middle-income countries. There is no vaccine and treatments are inadequate. A piperazine-based compound MMV665917 has in vitro and in vivo efficacy against C. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz105DOI Listing
March 2019
13 Reads

A protocol to count Cryptosporidium oocysts by flow cytometry without antibody staining.

PLoS Negl Trop Dis 2019 03 20;13(3):e0007259. Epub 2019 Mar 20.

National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

Cryptosporidiosis caused by the protozoan parasites Cryptosporidium hominis and C. parvum, threatens the lives of young children in developing countries. In veterinary medicine, C. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443187PMC
March 2019
1 Read

An apple a day: an outbreak of cryptosporidiosis in Norway associated with self-pressed apple juice.

Epidemiol Infect 2019 Jan;147:e139

Smittevernlege, Postboks 184, Fjell kommune, 5342 Straume,Norway.

In the autumn of 2018, an outbreak of cryptosporidiosis affected adult employees from the same company in Western Norway. The organism was Cryptosporidium parvum, GP60 subtype IIaA14G1R1. All those infected had drunk from the same container of self-pressed apple juice. Read More

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http://dx.doi.org/10.1017/S0950268819000232DOI Listing
January 2019

Analysis of the Cryptosporidium spp. and gp60 subtypes linked to human outbreaks of cryptosporidiosis in England and Wales, 2009 to 2017.

Parasit Vectors 2019 Mar 12;12(1):95. Epub 2019 Mar 12.

National Infection Service, Public Health England, 61, Colindale Avenue, London, UK.

Background: Cryptosporidium spp. are important causes of gastroenteritis that can be transmitted from humans and animals. We elucidated the distribution of species and gp60 subtypes in human outbreaks classified by transmission vehicle. Read More

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http://dx.doi.org/10.1186/s13071-019-3354-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417012PMC

A retrospective molecular study of Cryptosporidium species and genotypes in HIV-infected patients from Thailand.

Parasit Vectors 2019 Mar 12;12(1):91. Epub 2019 Mar 12.

Department of Infectious Disease, Istituto Superiore di Sanità, Rome, Italy.

Background: Opportunistic infections represent a serious health problem for HIV-infected people. Among enteric infections, cryptosporidiosis, a severe and life-threatening diarrheal disease, is of particular importance in low economic settings where access to anti-retroviral therapy is limited. Understanding transmission routes is crucial in establishing preventive measures, and requires the use of informative genotyping methods. Read More

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http://dx.doi.org/10.1186/s13071-019-3348-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417249PMC

Cryptosporidiosis Outbreak Investigation in a Canadian Correctional Facility Using Novel Case Finding Tools.

J Correct Health Care 2019 Mar 13:1078345819832024. Epub 2019 Mar 13.

4 Haliburton, Kawartha, Pine Ridge District Health Unit, Port Hope, Ontario, Canada.

Eliminating Cryptosporidium oocysts is particularly challenging in prison environments, and limited information is available on best practices for outbreak control. This report aims to expand the evidence base through the lessons learned from an outbreak at a Canadian federal penitentiary in 2013. The outbreak investigation methods included inmate and staff case finding, hypothesis-generating questionnaires, and environmental investigation. Read More

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http://dx.doi.org/10.1177/1078345819832024DOI Listing
March 2019
1 Read

2 What's Bugging You? Alliaceous Therapy for Ekbom Syndrome.

CNS Spectr 2019 Feb;24(1):175-176

4Smell and Taste Treatment and Research Foundation,Chicago,IL.

Study ObjectiveDelusional parasitosis, or Ekbom syndrome, is a fixed false belief of being infested by parasites [Bellanger 2009]. With easy accessibility of the internet, serving as a vital tool in acquiring myriad information, these delusions typically arise and can be fueled by external sources as self-research [Bell2005]. For instance, garlic (allium sativum) has been reported to exhibit anthelmintic activity against cestodes (tapeworms), proving to be a natural treatmentoption [Abdel-Ghaffar 2010]. Read More

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http://dx.doi.org/10.1017/S1092852919000026DOI Listing
February 2019
6 Reads

Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.

Cell Mol Gastroenterol Hepatol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina; Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina; Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, and North Carolina State University, Raleigh, North Carolina. Electronic address:

Background & Aims: The epithelial response is critical for intestinal defense against Cryptosporidium, but is poorly understood. To uncover the host strategy for defense against Cryptosporidium, we examined the transcriptional response of intestinal epithelial cells (IECs) to C parvum in experimentally infected piglets by microarray. Up-regulated genes were dominated by targets of interferon (IFN) and IFN-λ3 was up-regulated significantly in infected piglet mucosa. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.007DOI Listing

Evolutionary genomics of anthroponosis in Cryptosporidium.

Nat Microbiol 2019 Mar 4. Epub 2019 Mar 4.

Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK.

Human cryptosporidiosis is the leading protozoan cause of diarrhoeal mortality worldwide, and a preponderance of infections is caused by Cryptosporidium hominis and C. parvum. Both species consist of several subtypes with distinct geographical distributions and host preferences (that is, generalist zoonotic and specialist anthroponotic subtypes). Read More

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http://dx.doi.org/10.1038/s41564-019-0377-xDOI Listing
March 2019
2 Reads

The Global Burden of Disease of Zoonotic Parasitic Diseases: Top 5 Contenders for Priority Consideration.

Authors:
Konrad Pisarski

Trop Med Infect Dis 2019 Mar 2;4(1). Epub 2019 Mar 2.

Division of Tropical Health & Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4814, Australia.

With the rise of global migration, international trade, and global environmental challenges such as climate change, it is not surprising that the interactions between humans and other animals are shifting. Salient infectious diseases, such as malaria and HIV (which have high burdens of disease), attract sophisticated public health frameworks and funding from global/regional organisations, such as the WHO. This unfortunately detracts attention from the many emerging zoonoses that fall under the radar as neglected tropical diseases (NTDs). Read More

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http://dx.doi.org/10.3390/tropicalmed4010044DOI Listing

Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

J Med Chem 2019 Mar 15;62(6):3135-3146. Epub 2019 Mar 15.

Department of Medicine, Division of Allergy & Infectious Disease, Center for Emerging & Re-Emerging Infectious Disease (CERID) , University of Washington , Seattle , Washington 98109 , United States.

Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently, there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are effective in both in vitro and in vivo models of Cryptosporidium parvum. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00069DOI Listing

Comparison of Cryptosporidium oocyst recovery methods for their applicability for monitoring of consumer-ready fresh shellfish.

Int J Food Microbiol 2019 May 19;296:14-20. Epub 2019 Feb 19.

Department of Food and Environmental Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, Poland. Electronic address:

Growing demand for fresh, unprocessed food favours the emergence of Cryptosporidium infections in humans. Mainly it is food of plant origin or unpasteurized milk which have been involved in food-borne outbreaks of cryptosporidiosis. So far consumption of shellfish contaminated with Cryptosporidium were not associated with human infections although such as possibility exists. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.02.011DOI Listing
May 2019
2 Reads

First Report of Cryptosporidium molnari-Like Genotype and Cryptosporidium parvum Zoonotic Subtypes (IIaA15G2R1 and IIaA18G3R1) in Brown Trout ( Salmo trutta).

J Parasitol 2019 Feb;105(1):170-179

1   Laboratory of Parasitology, Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, A Coruña, Spain.

This study reports for the first time the molecular characterization of Cryptosporidium spp. in Salmo trutta. A total number of 613 brown trout was captured by local anglers in 44 Galician rivers within 10 river basins (NW Spain) during the 2015 fishing season (March-August) and classified into groups according to their size. Read More

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February 2019
3 Reads

Distribution of Cryptosporidium parvum gp60 subtypes in calf herds of Saxony, Germany.

Parasitol Res 2019 Feb 21. Epub 2019 Feb 21.

Institute of Parasitology, Centre for Infectious Diseases, University of Leipzig, An den Tierkliniken 35, D - 04103, Leipzig, Germany.

Cryptosporidiosis is a common protozoan parasitic infection that causes diarrhoea in neonatal calves. The high shedding of environmentally resistant oocysts facilitates outbreaks of cryptosporidiosis in humans. In total, 58 farms (512 calves) in Germany (Saxony and Brandenburg) were visited three times each. Read More

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http://dx.doi.org/10.1007/s00436-019-06266-1DOI Listing
February 2019
2 Reads

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Infection.

Antimicrob Agents Chemother 2019 Apr 27;63(4). Epub 2019 Mar 27.

Department of Biochemistry, University of Washington, Seattle, Washington, USA

Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most needy populations of malnourished children and HIV-infected persons. We describe here the discovery and early optimization of a class of imidazopyridine-containing compounds with potential for treating infections. Read More

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http://dx.doi.org/10.1128/AAC.02061-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437504PMC
April 2019
2 Reads

Multilocus fragment analysis of Cryptosporidium parvum from pre-weaned calves in Colombia.

Acta Trop 2019 Apr 7;192:151-157. Epub 2019 Feb 7.

Department of Animal Pathology, Faculty of Veterinary Sciences, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain; Agrifood Institute of Aragon (IA2), University of Zaragoza-CITA, Miguel Servet 177, 50013, Zaragoza, Spain. Electronic address:

The intra-species genetic diversity of Cryptosporidium parvum in dairy cattle farms in the central area of Colombia was investigated using a multilocus fragment typing approach with nine variable-number tandem-repeat (VNTR) loci and the gp60 gene. Genomic DNA of 70 C. parvum isolates from pre-weaned calves in 32 farms was analysed. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.005DOI Listing

Detection of Cryptosporidium parvum DNA in fecal samples of infected cattle (Bos indicus) and water buffaloes (Bubalus bubalis) in the Philippines using loop mediated isothermal amplification method

Ann Parasitol 2018;64(4):331-338

College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines

Fecal DNA samples from 17 cattle and 38 water buffaloes found to be infected with Cryptosporidium oocysts using Kinyoun acid fast stain from a previous study, were subjected to loop-mediated isothermal amplification (LAMP) assay using specific primers for Cryptosporidium parvum (C. parvum) from three municipalities, Maria, Baler and San Luis of the province of Aurora in the Philippines. Results of the fecalysis using Kinyoun acid fast stain and LAMP assay were compared with the PCR results of the examined farmer/owner who raised these animals to determine the possible zoonoses of C. Read More

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[Differences by geographical information system in prevalence of disease in a farm animal practise].

Schweiz Arch Tierheilkd 2019 Feb;161(2):85-92

Abteilung für Veterinärepidemiologie, Vetsuisse-Fakultät, Universität Zürich.

Introduction: In the present study, the incidence of diseases in cattle in the area of a veterinary practice was analyzed spatially. Furthermore, the relationship between the incidence of diseases and the distance to geographical elements was investigated. For this study, all cattle farms that were customers of the ambulatory clinic of the animal hospital in Zurich (Tierspital Zürich) were exactly localized on a map. Read More

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http://dx.doi.org/10.17236/sat00195DOI Listing
February 2019

Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in pre-weaned dairy calves in Guangdong, China.

Parasit Vectors 2019 Jan 17;12(1):41. Epub 2019 Jan 17.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

Background: Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi are common enteric pathogens in humans and animals. Data on the transmission of these pathogens are scarce from Guangdong, China, which has a subtropical monsoon climate and is the epicenter for many emerging infectious diseases. Read More

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http://dx.doi.org/10.1186/s13071-019-3310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337774PMC
January 2019
6 Reads

Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Infection.

Infect Immun 2019 Apr 25;87(4). Epub 2019 Mar 25.

Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA

, a protozoan parasite that infects the gastrointestinal epithelium and other mucosal surfaces in humans and animals, is an important opportunistic pathogen in AIDS patients and one of the most common enteric pathogens affecting young children in developing regions. This parasite is referred to as a "minimally invasive" mucosal pathogen, and epithelial cells play a central role in activating and orchestrating host immune responses. We previously demonstrated that infection stimulates host epithelial cells to release exosomes, and these released exosomes shuttle several antimicrobial peptides to carry out anti- activity. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00705-18
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http://dx.doi.org/10.1128/IAI.00705-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434132PMC
April 2019
5 Reads

MicroRNA expression profile of HCT-8 cells in the early phase of Cryptosporidium parvum infection.

BMC Genomics 2019 Jan 14;20(1):37. Epub 2019 Jan 14.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, People's Republic of China.

Background: Cryptosporidium parvum is an important zoonotic parasitic disease worldwide, but the molecular mechanisms of the host-parasite interaction are not fully understood. Noncoding microRNAs (miRNAs) are considered key regulators of parasitic diseases. Therefore, we used microarray, qPCR, and bioinformatic analyses to investigate the intestinal epithelial miRNA expression profile after Cryptosporidium parvum infection. Read More

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-5410-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332841PMC
January 2019
15 Reads
3.986 Impact Factor

Anthroponotic transmission of Cryptosporidium parvum predominates in countries with poorer sanitation: a systematic review and meta-analysis.

Parasit Vectors 2019 Jan 8;12(1):16. Epub 2019 Jan 8.

The Norwich Medical School, University of East Anglia, Norwich, UK.

Background: Globally cryptosporidiosis is one of the commonest causes of mortality in children under 24 months old and may be associated with important longterm health effects. Whilst most strains of Cryptosporidium parvum are zoonotic, C. parvum IIc is almost certainly anthroponotic. Read More

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http://dx.doi.org/10.1186/s13071-018-3263-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323761PMC
January 2019
1 Read

Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease.

ChemMedChem 2019 Feb 30;14(4):386-453. Epub 2019 Jan 30.

School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa.

The Pathogen Box is a 400-strong collection of drug-like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in-depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure-activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community. Read More

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http://dx.doi.org/10.1002/cmdc.201800755DOI Listing
February 2019

TREATMENT OF CRYPTOSPORIDIUM SERPENTIS INFECTION IN A KING COBRA ( OPHIOPHAGUS HANNAH) WITH PAROMOMYCIN.

J Zoo Wildl Med 2018 Dec;49(4):1061-1063

Feces collected from a wild-caught, young adult king cobra ( Ophiophagus hannah) were repeatedly positive for Cryptosporidium on both direct immunofluorescent antibody (DFA) and polymerase chain reaction (PCR), and sequencing identified the organism as Cryptosporidium serpentis. Infection was subclinical, as the snake was in good body condition and active, and readily consumed dead rats that were scented with snake skin. A course of paromomycin, inserted in feeder rats, was initiated at 360 mg/kg, orally, twice weekly for 6 wk. Read More

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http://zoowildlifejournal.com/doi/10.1638/2018-0080.1
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http://dx.doi.org/10.1638/2018-0080.1DOI Listing
December 2018
2 Reads

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report.

BMC Infect Dis 2018 Dec 27;18(1):704. Epub 2018 Dec 27.

Medical student, Universidad Tecnológica de Pereira, Pereira, Colombia.

Background: Those infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307277PMC
December 2018
8 Reads

Occurrence of zoonotic Cryptosporidium and Giardia duodenalis species/genotypes in urban rodents.

Parasitol Int 2019 Apr 24;69:110-113. Epub 2018 Dec 24.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

This report describes the detection of zoonotic Cryptosporidium muris, C. parvum subgenotype IIa and Giardia duodenalis genotype B in urban rodents in Malaysia. A rare occurrence of C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835769183038
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http://dx.doi.org/10.1016/j.parint.2018.12.007DOI Listing
April 2019
15 Reads
2.111 Impact Factor

Study on Giardia duodenalis and Cryptosporidium spp. infection in veterinarians in Poland.

Ann Agric Environ Med 2018 Dec 18;25(4):732-733. Epub 2018 Dec 18.

Institute of Rural Health, Lublin, Poland.

The risk of exposure to zoonotic factors among veterinarians comprises still underestimated problem. Many etiological factors of infectious diseases are so far poorly known, including the way of their transmission from environment to humans and their impact for health. The main aim of the study was to determine the risk of two selected zoonosis infections caused by Giardia duodenalis and Cryptosporidium spp. Read More

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http://dx.doi.org/10.26444/aaem/101576DOI Listing
December 2018
1 Read

Imported cryptosporidiosis caused by Cryptosporidium hominis IbA13G3 in Spain. The relevance of molecular-based surveillance.

Enferm Infecc Microbiol Clin 2018 Dec 21. Epub 2018 Dec 21.

Parasitology Reference and Research Laboratory, National Centre for Microbiology, Health Institute Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2018.11.010DOI Listing
December 2018
1 Read

Persistent Occurrence of and Subtypes in a Welfare Institute.

Front Microbiol 2018 20;9:2830. Epub 2018 Nov 20.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Few data are available on the transmission dynamics of intestinal protozoa in children in welfare institutes. In this study, fecal specimens were collected from 396 children in a welfare institute in Shanghai, China during December 2011 (207 specimens), June 2012 (78 specimens), and September 2013 (111 specimens), and examined for spp., , and by PCR analysis of the small subunit rRNA, triosephosphate isomerase, and internal transcribed spacer genes, respectively. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256193PMC
November 2018
3 Reads

Beyond reasonable drought: hotspots reveal a link between the 'Big Dry' and cryptosporidiosis in Australia's Murray Darling Basin.

J Water Health 2018 Dec;16(6):1033-1037

National Centre for Geographic and Resource Analysis in Primary Health Care, Australian National University, Canberra, 2600, Australia.

There is little evidence on how the health impacts of drought vary spatially and temporally. With a focus on waterborne cryptosporidiosis, we identify spatio-temporal hotspots and by using interrupted time series analysis, examine the impact of Australia's Big Dry (2001-2009) in these disease clusters in the Murray Darling Drainage Basin. Analyses revealed a statistically significant hotspot in the north of the Australian Capital Territory (ACT) and a hotspot in the north-eastern end of the basin in Queensland. Read More

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http://dx.doi.org/10.2166/wh.2018.199DOI Listing
December 2018

infection in chronic kidney disease patients undergoing hemodialysis in Egypt.

J Parasit Dis 2018 Dec 19;42(4):630-635. Epub 2018 Oct 19.

4Department of Zoology, Faculty of Science, Damanhour University, Damanhûr, 21634 Egypt.

Patients with chronic renal failure are more susceptible to infections due to acquired immunodeficiency caused by uremia. Parasitic infections are one of the significant causes of morbidity and mortality in those patients, So we aimed to assess the prevalence of spp. and other protozoan infections in patients undergoing hemodialysis in Qena Governorate, Upper Egypt. Read More

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http://dx.doi.org/10.1007/s12639-018-1046-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261133PMC
December 2018
2 Reads

Draft Genome Assembly of a Potentially Zoonotic Cryptosporidium parvum Isolate, UKP1.

Microbiol Resour Announc 2018 Nov 15;7(19). Epub 2018 Nov 15.

National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada.

Cryptosporidium parvum is a zoonotic protozoan parasite that causes food and waterborne gastrointestinal disease and whose major animal reservoirs are cattle and small ruminants. We report here on a draft whole-genome sequence of a zoonotic isolate of C. parvum isolated from a person with cryptosporidiosis. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.01291-18
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http://dx.doi.org/10.1128/MRA.01291-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256480PMC
November 2018
10 Reads

Past and future trends of Cryptosporidium in vitro research.

Exp Parasitol 2019 Jan 3;196:28-37. Epub 2018 Dec 3.

Laboratory of Molecular and Evolutionary Parasitology, RAPID Group, School of Biosciences, University of Kent, Canterbury, Kent, UK; School of Biosciences, University of Kent, Canterbury, Kent, UK. Electronic address:

Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333944PMC
January 2019
5 Reads

Identification of novel vaccine candidates against cryptosporidiosis of neonatal bovines by reverse vaccinology.

Vet Parasitol 2018 Dec 12;264:74-78. Epub 2018 Nov 12.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Argentina; Facultad de Ciencias exactas, químicas y naturales (FCEQN), Universidad de Morón, Morón, Argentina. Electronic address:

The apicomplexan protozoan Cryptosporidium parvum is an important causative agent of diarrhea of neonatal bovines. Vaccination has been proposed as an advantageous strategy against cryptosporidiosis of calves since besides protection against disease it has also the potential to prevent dissemination of infective oocysts into the environment. Antigens anchored to the parasite surface via glycosylphosphatidylinositol (GPI) are implicated in host cell attachment and invasion and represent promising vaccine candidates. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.007DOI Listing
December 2018
4 Reads

Disinfection with hydrated lime may help manage cryptosporidiosis in calves.

Vet Parasitol 2018 Dec 10;264:58-63. Epub 2018 Nov 10.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054 SE-750 07 Uppsala, Sweden.

Diarrhea is common in young calves and is often caused by Cryptosporidium parvum infection. The aim of this study was to investigate if disinfection of calf pens with hydrated lime would reduce contamination of C. parvum oocysts and improve calf health in herds with C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044017183037
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http://dx.doi.org/10.1016/j.vetpar.2018.11.004DOI Listing
December 2018
12 Reads

First Cryptosporidium outbreak in Hungary, linked to a treated recreational water venue in 2015.

Epidemiol Infect 2018 Dec 3:1-6. Epub 2018 Dec 3.

Cryptosporidium Reference Unit, Public Health Wales Microbiology and Health Protection, Singleton Hospital,Swansea,UK.

In June 2015, an outbreak of cryptosporidiosis with 35 cases (23 probable and 12 laboratory-confirmed) occurred among 191 attendees of a residential rehabilitation holiday for paediatric organ transplant patients (n = 49) and their families at a hotel in Somogy county, Hungary. The overall attack rate was 18%. Most of the cases were transplanted children who experienced severe acute disease and required adjustment to their tacrolimus immunosuppression. Read More

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http://dx.doi.org/10.1017/S0950268818003138DOI Listing
December 2018
2 Reads

Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting.

Am J Trop Med Hyg 2019 Jan;100(1):78-80

Department of Infectious Diseases, Singapore General Hospital, Singapore.

In high prevalence settings, cryptosporidiosis is commonly implicated as a cause of a gastroenteritis syndrome in the organ transplant population. Stool microscopy is predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335919PMC
January 2019
20 Reads

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.

J Enzyme Inhib Med Chem 2019 Dec;34(1):171-178

a Division of Applied Bioscience, Graduate School of Agriculture , Hokkaido University , Sapporo , Japan.

Inosine 5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the present study, we established a luciferase-based high-throughput screening system to identify IMPDH inhibitors from our chemical library of known bioactive small molecules. Read More

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
Publisher Site
http://dx.doi.org/10.1080/14756366.2018.1540474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249553PMC
December 2019
29 Reads

Development of Molecular Diagnosis Using Multiplex Real-Time PCR and T4 Phage Internal Control to Simultaneously Detect Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis from Human Stool Samples.

Korean J Parasitol 2018 Oct 31;56(5):419-427. Epub 2018 Oct 31.

Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 03080, Korea.

This study aimed to develop a new multiplex real-time PCR detection method for 3 species of waterborne protozoan parasites (Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis) identified as major causes of traveler's diarrhea. Three target genes were specifically and simultaneously detected by the TaqMan probe method for multiple parasitic infection cases, including Cryptosporidium oocyst wall protein for C. parvum, glutamate dehydrogenase for G. Read More

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http://dx.doi.org/10.3347/kjp.2018.56.5.419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243187PMC
October 2018
2 Reads