9,831 results match your criteria Cryptorchidism Imaging


Birth outcomes after inadvertent use of category X drugs contraindicated in pregnancy: Where is the real risk?

Turk J Pediatr 2018 ;60(3):298-305

Department of Pharmacology, Celal Bayar University, Manisa, Turkey.

Öztürk Z, Ölmez E, Gürpınar T, Vural K. Birth outcomes after inadvertent use of category X drugs contraindicated in pregnancy: Where is the real risk? Turk J Pediatr 2018; 60: 298-305. Drugs contraindicated in pregnancy are medicines that should be avoided by pregnant women, since they carry a concern for teratogenicity or there is no indication for their use during pregnancy. Read More

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January 2018
2 Reads

[Clinical and genetic features of Kallmann syndrome: an analysis of 5 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Nov;20(11):925-929

Department of Pediatrics, First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China.

Kallmann syndrome (KS) is a rare pediatric disease with major manifestations of olfactory dysfunction and hypogonadotropic hypogonadism. Five children (4 boys and 1 girl) with KS reported in this article were aged between 6 months and 19 years at the time when they attended the hospital. All the children had the clinical manifestation of hypogonadotropic hypogonadism; in addition, three children had olfactory dysfunction (two were found to have olfactory bulb dysplasia on magnetic resonance imaging), one had cleft lip and palate, and one had micropenis and cryptorchidism with right renal agenesis during infancy. Read More

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November 2018
5 Reads

Undescended Testes and Laparoscopy: Experience from the Developing World.

Adv Urol 2018 24;2018:1620470. Epub 2018 Oct 24.

MS General Surgery, Consultant Surgeon, GMC-Jammu, Jammu and Kashmir, India.

Background: Cryptorchidism or undescended testes is the most common disorder of the male endocrine glands in children. With the advancements in laparoscopic techniques and instruments, laparoscopic orchidopexy has become the standard procedure in the management of nonpalpable undescended testes.

Aim: To evaluate and determine the therapeutic role, sensitivity, and specificity of laparoscopy in localizing nonpalpable testes and the mean operative time, the conversion rate (and reasons thereof), postoperative wound infection, postoperative stay, and time taken for return to daily activities following laparoscopic orchidopexy or orchidectomy. Read More

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October 2018
1 Read

Maternal smoking during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis.

Eur J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Children's Hospital of Chongqing Medical University, Room 806, Kejiao Building (No. 6 Building), No. 136, 2nd Zhongshan Road, Yuzhong District, Chongqing City, 400014, China.

The risk factors for undescended testes in male infants and the underlying pathogenesis still remain unclear. The aim of this study is to identify the relationship between maternal smoking during pregnancy and risk of cryptorchidism. A systematic review was conducted using appropriate search terms to identify articles pertaining to maternal smoking during pregnancy and risk of cryptorchidism. Read More

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November 2018
6 Reads

Molecular Diagnosis of Rare Autosomal Recessive Escobar Syndrome in a Consanguineous Pakistani Family.

Genet Test Mol Biomarkers 2018 Nov 21. Epub 2018 Nov 21.

Medical Genetics Research Laboratory, Department of Biotechnology, Quaid-i-Azam University , Islamabad, Pakistan .

Background: Escobar syndrome, a nonlethal variant of multiple pterygium syndromes (MPS), is a rare autosomal recessive disorder characterized by pterygia and multiple joint contractures along with other anomalies. Variants in cholinergic receptor nicotinic gamma subunit (CHRNG) have been previously reported in patients with Escobar syndrome.

Objective: We studied a consanguineous Pakistani family affected with Escobar syndrome to identify the underlying genetic defect through short tandem repeat (STR) genotyping and direct DNA sequencing. Read More

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November 2018
7 Reads

Persistent Mullerian duct syndrome: Report of two cases with phenotypical immunohistochemical profiling.

Urologia 2018 Nov 28;85(4):177-181. Epub 2018 Mar 28.

1 Pathology Service, Addarii Institute of Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Introduction:: Persistent Mullerian duct syndrome is a rare disorder of male organ development characterized by internal male pseudohermaphroditism. Persistent Mullerian duct syndrome is usually an incidental finding in patients presenting cryptorchidism, inguinal hernia, or a previous story of undescended testes.

Case Description:: We report on two cases of persistent Mullerian duct syndrome: an adult fertile male with uterus and ectopic prostate occurring as pelvic mass and a 75-year-old organ donor with uterus and two fallopian tubes, discovered in course of organ recruitment. Read More

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November 2018
5 Reads

Transverse testicular ectopia discovered following reduction of an inguinal hernia.

J Pediatr Surg 2018 Oct 22. Epub 2018 Oct 22.

Department of Surgery, Division of Pediatric Surgery, Hospital Quironsalud Sur, Madrid, Spain. Electronic address:

Transverse testicular ectopia is a rare condition in which both testicles occupy a single hemiscrotum. The aberrant positioning may lead to vascular compromise or impaired temperature regulation, which elevate the risks for torsion, infertility and testicular cancer. Definitive therapy consists of orchiectomy or orchiopexy. Read More

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October 2018
1 Read

Evaluation of Fowler-Stephens orchiopexy for high-level intra-abdominal cryptorchidism: A systematic review and meta-analysis.

Int J Surg 2018 Nov 5;60:74-87. Epub 2018 Nov 5.

Department of Urology, Children's Hospital of Chongqing Medical University, China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, China; Ministry of Education Key Laboratory of Child Development and Disorders, China; Chongqing Key Laboratory of Pediatrics Chongqing, China. Electronic address:

Background And Objective: There has been no consensus regarding the best surgical strategy for patients with cryptorchidism involving high-level intra-abdominal testes. This systematic review and meta-analysis compared the outcomes of Fowler-Stephens orchiopexy (FSO) conducted as 1-stage or 2-stage, open or laparoscopic.

Methods: The databases PubMed, Cochrane Library, Web of Science Database, Russian Science Citation Index, SciELO Citation Index, China National Knowledge Infrastructure, WanFang Data, and China Biology Medical disc were systematically searched for relevant articles. Read More

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November 2018
5 Reads

A case of splenogonadal fusion accompanied by accessory spleen in a 4-year-old boy.

Urol Ann 2018 Oct-Dec;10(4):406-408

Shiraz Nephro-Urology Research Center, Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran.

Splenogonadal fusion (SGF) is a rare benign malformation in which spleen is aberrantly attached to the gonads or mesonephric derivatives. This entity often presents with scrotal mass, inguinal hernia, or cryptorchidism. Herein, we report our experience with a boy who presented with a scrotal enlargement which later turned out to be SGF. Read More

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November 2018
2 Reads

Utilization of scrotal orchidopexy for palpable undescended testes among surgeons.

Urol Ann 2018 Oct-Dec;10(4):380-385

Department of Surgery, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Introduction: Scrotal orchidopexy for palpable undescended testicle (UDT) has received attention in the last decade due to its lower morbidity. This study was conducted to determine the frequency and factors related to the use of the scrotal approach in the surgical treatment of palpable UDT among surgeons.

Methods: An observational cross-sectional study was carried out using an online survey, which was sent to different pediatric urologists, pediatric surgeons, and urologists groups. Read More

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November 2018
2 Reads

Hypogonadotropic Hypogonadism and Kleefstra Syndrome due to a Pathogenic Variant in the Gene: An Underrecognized Association.

Case Rep Endocrinol 2018 2;2018:4283267. Epub 2018 Oct 2.

Division of Pediatric Endocrinology and Diabetes, Rhode Island Hospital/Hasbro Children's Hospital, The Warren Alpert Medical School of Brown University, 111 Plain St, 3rd Floor, Providence, RI 02903, USA.

Kleefstra syndrome is a genetic condition characterized by intellectual disability, childhood hypotonia, and facial dysmorphisms. Genital anomalies such as micropenis, cryptorchidism, and hypospadias have been reported in 30-40% of males diagnosed with the disease. However, endocrinological investigations have been limited. Read More

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October 2018
2 Reads

Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series.

Urol Int 2018 Oct 26:1-5. Epub 2018 Oct 26.

Department of Pediatric Surgery, Woman's and Children's Hospital, Shenzhen University and Pingshan District, Shenzhen, China.

Objective: To investigate the clinical features, diagnosis, treatment and prognosis of children with cryptorchidism complicated by testicular torsion.

Methods: The clinical data of 6 children with cryptorchidism complicated by testicular torsion admitted to our hospital from December 2000 to December 2016 were analyzed retrospectively.

Results: All 6 children were diagnosed with cryptorchidism by surgery, their age was from 12 days up to 11 years, and the average time between onset of symptoms and diagnosis was 20. Read More

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October 2018
5 Reads

Single-Port Laparoscopic Assisted Transcrotal Orchidopexy for Palpable Inguinal Canalicular Cryptorchidism Accompany With Indirect Inguinal Hernia.

Front Pediatr 2018 9;6:293. Epub 2018 Oct 9.

Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

To assess the outcomes of a novel laparoscopic assisted transcrotal orchidopexy (LATO) combined with percutaneous extraperitoneal closure (PEC) for palpable inguinal canalicular cryptorchidism accompany with indirect inguinal hernia, and evaluate its safety and efficiency. A retrospective cohort study for single-port LATO-PEC and traditional inguinal orchidopexy (TIO) was performed between 2011 and 2014. Totally 53 children with both palpable inguinal canalicular testes and indirect inguinal hernia were included. Read More

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October 2018
6 Reads

Male Central Hypogonadism in Paediatrics - the Relevance of Follicle-stimulating Hormone and Sertoli Cell Markers.

Eur Endocrinol 2018 Sep 10;14(2):67-71. Epub 2018 Sep 10.

Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), National Scientific and Technical Research Council (CONICET) - Fundación de Endocrinología Infantil (FEI) - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.

The definition of male hypogonadism, used in adult endocrinology, is not fully applicable to paediatrics. A clear understanding of the developmental physiology of the hypothalamic-pituitary-testicular axis is essential for the comprehension of the pathogenesis of hypogonadal states in boys and for the establishment of adequate definitions and classifications in paediatric ages. This is particularly true for central hypogonadism, usually called hypogonadotropic in adults. Read More

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September 2018
1 Read

Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence.

Environ Int 2018 Dec 16;121(Pt 1):764-793. Epub 2018 Oct 16.

U.S. Environmental Protection Agency, National Center for Environmental Assessment, United States; The Innocence Project, United States.

Objective: We performed a systematic review of the epidemiology literature to identify the male reproductive effects associated with phthalate exposure.

Data Sources And Study Eligibility Criteria: Six phthalates were included in the review: di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of male reproductive effects in humans, and outcomes were selected for full systematic review based on data availability. Read More

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December 2018

Modified 2-port laparoscopic herniorrhaphy with Kirschner wire in children: A retrospective review.

Medicine (Baltimore) 2018 Oct;97(42):e12790

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou.

Background: Pediatric inguinal hernia is one of the most common diseases in children, and laparoscopy is the main surgical method. This study aims to evaluate the efficacy of a new modified 2-port laparoscopic herniorrhaphy with Kirschner wire (TLHK) for inguinal hernia in children.

Methods: A total of 5304 children with inguinal hernia hospitalized at the Jiangmen Center Hospital from June 2003 to May 2016 were enrolled in this retrospective study. Read More

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October 2018

A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity

Endocrinol Diabetes Metab Case Rep 2018 Oct 13;2018(1):18-0108. Epub 2018 Oct 13.

Department of Endocrinology, BSMMU, Dhaka, Bangladesh.

Congenital adrenal hyperplasia (CAH) due to the three-beta-hydroxysteroid-dehydrogenase (3β-HSD) enzyme deficiency is a rare autosomal recessive disorder presenting with sexual precocity in a phenotypic male. Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy presenting with hypergonadotropic hypogonadism in a male. However, only a handful of cases of mosaic KS have been described in the literature. Read More

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October 2018
3 Reads

miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2.

Reprod Biol Endocrinol 2018 Oct 15;16(1):97. Epub 2018 Oct 15.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Background: Cryptorchidism as a common genitourinary malformation with the serious complication of male infertility draws widespread attention. With several reported miRNAs playing critical roles in spermatogonial stem cells (SSCs), we aimed to explore the fundamental function of the highly conserved miR-34c in cryptorchidism.

Methods: To explore whether miR-34c participates in spermatogenesis by regulating Nanos2, we examined the effect of overexpression and inhibition for miR-34c on Nanos2 expression in GC-1 cells. Read More

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October 2018
1 Read

Parental subfertility and hypospadias and cryptorchidism in boys: results from two Danish birth cohorts.

Fertil Steril 2018 Oct;110(5):826-832

Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus University Hospital, Aarhus, Denmark.

Objective: To study if parental subfertility is related to the occurrence of the male genital anomalies, cryptorchidism and hypospadias.

Design: Population-based cohort study.

Setting: Not applicable. Read More

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October 2018
3 Reads

Fertility Issues in Pediatric Urology.

Urol Clin North Am 2018 Nov 7;45(4):587-599. Epub 2018 Sep 7.

Division of Urology, Seattle Children's Hospital, 4800 Sand Point Way Northeast, OA.9.220, Seattle, WA 98105, USA.

Improved understanding of the pathogenesis and natural history of many urologic disorders, as well as advances in fertility preservation techniques, has increased the awareness of and options for management of fertility threats in pediatric patients. In children, fertility may be altered by oncologic conditions, by differences in sexual differentiation, by gonadotoxic drugs and other side effects of treatment for nonurologic disorders, and by urologic conditions, such as varicocele and cryptorchidism. Although fertility concerns are best addressed in a multidisciplinary setting, pediatric urologists should be aware of the underlying pathophysiology and management options to properly counsel and advocate for patients. Read More

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November 2018
1 Read

Exploration of the fetus with gross anomaly: a case of pseudo prune belly syndrome.

Anat Cell Biol 2018 Sep 28;51(3):205-208. Epub 2018 Sep 28.

Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Prune belly syndrome is a rare congenital anomaly usually presented with triad characteristic feature of deficient abdominal muscles, cryptorchidism, and urinary tract anomalies. Here, we present a case with all the characteristic features of prune belly and the associated secondary features which were observed on detailed dissection and exploration of the fetus. Read More

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September 2018
1 Read

Testicular cancer.

Nat Rev Dis Primers 2018 Oct 5;4(1):29. Epub 2018 Oct 5.

Department of Pathology, Josephine Nefkens Building, Erasmus MC-University Medical Center, Cancer Institute, Rotterdam, Netherlands.

Testicular cancer is the most common malignancy among men between 14 and 44 years of age, and its incidence has risen over the past two decades in Western countries. Both genetic and environmental factors contribute to the development of testicular cancer, for which cryptorchidism is the most common risk factor. Progress has been made in our understanding of the disease since the initial description of carcinoma in situ of the testis in 1972 (now referred to as germ cell neoplasia in situ), which has led to improved treatment options. Read More

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October 2018
6 Reads

Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita.

Ann Pediatr Endocrinol Metab 2018 Sep 28;23(3):162-165. Epub 2018 Sep 28.

4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

X-linked adrenal hypoplasia congenita (AHC) is a rare disorder that usually presents clinically as adrenal insufficiency in early infancy. It is caused by mutations in the NR0B1 gene which is located on the short arm of chromosome X (Xp21). The NR0B1 gene plays an important role in normal development and function of both the adrenal and gonadal axes and some patients with the disease can present in adolescence with hypogonadotropic hypogonadism. Read More

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September 2018
1 Read

Clinical features, treatment, and outcomes of bilateral Wilms' tumor: A systematic review and meta-analysis.

J Pediatr Surg 2018 Sep 1. Epub 2018 Sep 1.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.

Background: Wilms' tumor(WT) is the most common malignant renal tumor of childhood. Despite the good prognosis of WT, bilateral Wilms' tumor (BWT) still has a poor outcome. We systematically reviewed the literature on BWT, aiming to define its clinical features, treatment, and outcomes. Read More

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September 2018

Mosaic trisomy 22 in a 4-year-old boy with congenital heart disease and general hypotrophy: A case report.

J Clin Lab Anal 2018 Sep 26:e22663. Epub 2018 Sep 26.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Trisomy 22 mosaicism is a rare autosomal anomaly with survival compatibility. Recognition of the complete trisomy 22 which is incompatible with life from the mosaic form is critical for genetic counseling. Affected mosaic cases have prevalent clinical presentations such as webbed neck, developmental delay, abnormal ears, cardiac disorders, and microcephaly. Read More

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September 2018
1 Read
1.140 Impact Factor

Gonadal function and pubertal development in patients with Silver-Russell syndrome.

Hum Reprod 2018 Nov;33(11):2122-2130

Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Study Question: Is gonadal function affected in males and females with Silver-Russell Syndrome (SRS)?

Summary Answer: Sertoli cell dysfunction is more common in males with SRS, with 11p15 LOM, but gonadal function seems to be unaffected in females with SRS.

What Is Known Already: Males with SRS have an increased risk for genital abnormalities such as cryptorchidism and hypospadias, which could be associated with reproductive problems in later life. In SRS females, an association has been described with Mayer-Rokitansky-Küster-Hauser syndrome, which might compromise their reproductive function. Read More

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November 2018
1 Read

Associations between hypospadias, cryptorchidism and anogenital distance: Systematic review and meta-analysis.

Andrologia 2018 Dec 24;50(10):e13152. Epub 2018 Sep 24.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Hypospadias and cryptorchidism are potential manifestations of testicular dysgenesis syndrome (TDS) at birth. Anogenital distance (AGD) has been presumed as an indicator related to endocrine disruptors proposed as one of the pathogenetic mechanisms underlying male reproductive disorders. In humans, recent studies have correlated AGD in boys to testicular anomalies. Read More

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December 2018
4 Reads

Autopsy findings of ectodermal dysplasia and sex development disorder in a fetus with 19q12q13 microdeletion.

Eur J Med Genet 2018 Sep 18. Epub 2018 Sep 18.

Centre de Génétique Humaine, Centre Hospitalier Universitaire, Université de Franche-Comté, Besançon, France.

A 5,6 Mb de novo 19q12-q13.12 interstitial deletion was diagnosed prenatally by array-comparative genomic hybridization in a 26 weeks male fetus presenting with intra-uterine growth retardation, left clubfoot, atypical genitalia and dysmorphic features. Autopsic examination following termination of pregnancy identified a severe disorder of sex development (DSD) including hypospadias, micropenis, bifid scrotum and right cryptorchidism associated with signs of ectodermal dysplasia: scalp hypopigmentation, thick and frizzy hair, absence of eyelashes, poorly developed nails and a thin skin with prominent superficial veins. Read More

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September 2018
5 Reads

Novel CNS malformations and skeletal anomalies in a patient with Beaulieu-boycott-Innes syndrome.

Am J Med Genet A 2018 Sep 20. Epub 2018 Sep 20.

UOC Neurochirurgia, Istituto Giannina Gaslini, Genoa, Italy.

THO/TREX (transcription/export) is a conserved eukaryotic complex that plays a crucial role in gene expression and prevents DNA damage during mitosis and meiosis. In mammals, TREX is essential during embryogenesis, determining stem cell fate specification by regulating posttranscriptional self-renewal and differentiation in several tissues. It is composed of a core called THO, consisting of THOC1, 2, 5, 6, 7, and additional proteins. Read More

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September 2018
5 Reads

unbalanced translocation t(15;22)(q26.2;q12) with velo-cardio-facial syndrome: A case report and review of the literature.

Exp Ther Med 2018 Oct 16;16(4):3589-3595. Epub 2018 Aug 16.

Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300173 Timisoara, Romania.

The present study reports the case of a 3-h old male with a unbalanced t(15;22) translocation and velo-cardio-facial syndrome (VCFS), with other abnormalities. The manifestations of the condition observed in the patient included cleft palate with feeding difficulties, respiratory infection, dysmorphic face with almond-shaped eyes, a long and wide nose, small and low-set ears, tetralogy of Fallot, cryptorchidism and varus equinus. Standard lymphocyte cytogenetic analysis using G-banding demonstrated a 45,XY,-22,der (15),t(15;22)(q26. Read More

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October 2018
86 Reads
0.940 Impact Factor

A novel missense mutation of the STS gene in two siblings with X-linked ichthyosis, complicated by short stature, bone density reduction, epilepsy, and cryptorchidism.

Clin Exp Dermatol 2019 Jan 16;44(1):78-79. Epub 2018 Sep 16.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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January 2019
6 Reads

Acquired undescended testis and possibly associated testicular torsion in children with cerebral palsy or neuromuscular disease.

J Pediatr Urol 2018 Aug 23. Epub 2018 Aug 23.

Department of Urology, Osaka Women's and Children's Hospital, Osaka, Japan.

Introduction: Torsion of an undescended testis (UDT) associated with cerebral palsy (CP) and neuromuscular disease (NMD) is an uncommon condition that is not well recognized by primary care physicians or healthcare providers.

Objective: The objective of this study was to highlight the clinical importance of torsion of a UDT in children with CP and NMD.

Materials And Methods: Eleven children with testicular torsion of a UDT operated on at the study institute between 1991 and 2015 were identified. Read More

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August 2018
3 Reads

Concerning the plausibility of the findings reported in 'Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case-control study' by Smet and Kelsey: authors' response.

Occup Environ Med 2018 Dec 14;75(12):917-918. Epub 2018 Sep 14.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

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December 2018

Fertility induction in hypogonadotropic hypogonadal men.

Clin Endocrinol (Oxf) 2018 Dec 9;89(6):712-718. Epub 2018 Oct 9.

Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK.

Men with hypogonadotropic hypogonadism (HH) are typically azoospermic, and yet HH is one of the few treatable forms of male infertility. Sperm induction protocols using gonadotrophins aim to replicate the natural endocrine control of spermatogenesis. Previously virilised men with adult-onset HH and normal testicular volume respond well to monotherapy in which human chorionic gonadotrophin (hCG) acts as a long-acting LH-analogue stimulating spermatogenesis. Read More

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December 2018

FEAT enhances INSL3 expression in testicular Leydig cells.

Genes Cells 2018 Nov 2;23(11):952-962. Epub 2018 Oct 2.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

FEAT, the protein encoded by methyltransferase-like 13 (METTL13), is aberrantly upregulated in most human cancers and potently drives tumorigenesis in vivo; however, its role in normal tissues remains elusive. Immunoblotting has displayed weak FEAT expression in normal human tissues, including the testis. Here, we found that FEAT is expressed in fetal and adult Leydig cells in the testis. Read More

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November 2018
3 Reads
2.810 Impact Factor

Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene.

J Comp Pathol 2018 May 1;161:20-24. Epub 2018 Jun 1.

Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland. Electronic address:

Disorders of sex development (DSD) are a serious health problem in dogs. Different types of DSD have been described, including persistent Müllerian duct syndrome (PMDS), for which the molecular background has been identified in miniature schnauzers. Human patients with PMDS are at increased risk for cancers of the gonads (predominantly) or the Müllerian duct structures (rarely). Read More

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[Micro-dissection testicular sperm extraction for non-obstructive azoospermia patients with the history of secondary testicular injury].

Zhonghua Nan Ke Xue 2018 08;24(8):681-685

Center of Reproduction, The Sixth Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510620, China.

Objective: To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury.

Methods: Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We analyzed the correlation of the sperm retrieval rate with the causes of testicular injury and compared the outcomes of the ICSI cycles with the sperm retrieved from the NOA males by micro-TESE (the micro-TESE group) and those with the sperm ejaculated from severe oligospermia patients (sperm concentration <1×10⁶/ml, the ejaculate group). Read More

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August 2018
23 Reads

Expanding morphological and clinical aspects of hereditary leiomyomatosis and renal cell carcinoma (HLRCC): a case report in a patient with unusual morphology and clinical presentation.

Virchows Arch 2018 Dec 31;473(6):775-779. Epub 2018 Aug 31.

Department of Pathology, AC Camargo Cancer Center, Rua Professor Antônio Prudente 211, São Paulo, 01509-900, Brazil.

Renal cell carcinoma (RCC) accounts for 2-3% of all malignant disease in adults. Hereditary RCC represents 5 to 8% of kidney tumors. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) represents an autosomal dominant syndrome that results from a germline mutation in fumarate hydratase gene (FH). Read More

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December 2018
19 Reads

Voiceless disability: A worth case of bilateral infrainguinal testicular torsion in a patient with cerebropalsy.

Ann Med Surg (Lond) 2018 Sep 20;33:47-49. Epub 2018 Aug 20.

Department of Paediatric Surgery, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Introduction: A fast surgical treatment is the gold standard when a testicular torsion is diagnosed.However, an early diagnosis of torsion may not be feasible in case of torsion associated with undescended testis in the patients affected by cerebropalsy.

Case Presentation: A Bolivian 16 year old male with acquired cerebropalsy and spastic neuromuscular disease was admitted to our Institute for a right inguinal swelling observed by the father in the morning. Read More

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September 2018

New insights into the morphological and hormonal characteristics of spermatogenic arrest.

Andrologia 2018 Dec 29;50(10):e13136. Epub 2018 Aug 29.

CHU Lille, Reproductive Biology Institute-Spermiologie-CECOS, Jeanne de Flandre Hospital, Lille, France.

The reported sperm retrieval rate (SRR) in patients with nonobstructive azoospermia (NOA) due to spermatogenic arrest (SA) is highly variable in the literature. This discrepancy could be explained by the heterogeneity of testicular tissues. Surprisingly, even though inhibin B levels reflect directly Sertoli cell function; no studies have evaluated this parameter in SA. Read More

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December 2018

Retrocaval ureter associated with cryptorchidism: A case report and review of literature.

Clin Case Rep 2018 Aug 1;6(8):1592-1594. Epub 2018 Jul 1.

Department of Urology National Hospital of Sri Lanka Colombo Sri Lanka.

We report an incidentally diagnosed retrocaval ureter in a 14-year-old boy, while evaluating for right-sided hydronephrosis associated with cryptorchidism. Therefore, we suggest that any significant right-sided hydronephrosis associated with cryptorchidism may require investigations to exclude this rare anomaly. Read More

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Role of Ozone Therapy in Preventing Testicular Damage in an Experimental Cryptorchid Rat Model.

Med Sci Monit 2018 Aug 21;24:5832-5839. Epub 2018 Aug 21.

Department of Medical Microbiology, Medical School of KTO Karatay University, Konya, Turkey.

BACKGROUND Cryptorchidism is the most common developmental abnormality of the male reproductive system. If left untreated, it results with infertility and testicular cancer. According to current evidence, surgery is the mainstay of treatment, and hormonal therapy approaches are still under investigation. Read More

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August 2018
2 Reads

[A rare cause of cryptorchidism, the persistence of müllerian ducts syndrome].

Rev Med Liege 2018 Jul;73(7-8):376-379

Service d'Urologie, CHR Citadelle, Liège, Belgique.

The Persistent Müllerian Ducts Syndrome (PMDS) is a rare congenital syndrome. It is one of abnormalities of genito-sexual development that is found on the normally virilized boy (46XY). It is characterized by the development of both Wolf structures and Müller duct. Read More

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July 2018
3 Reads

Phenotypic severity scoring system and categorisation for prune belly syndrome: application to a pilot cohort of 50 living patients.

BJU Int 2018 Aug 16. Epub 2018 Aug 16.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: To design a novel system of scoring prune belly syndrome (PBS) phenotypic severity at any presenting age and apply it to a large pilot cohort.

Patients And Methods: From 2000 to 2017, patients with PBS were recruited to our prospective PBS study and medical records were cross-sectionally analysed, generating individualised RUBACE scores. We designed the pragmatic RUBACE-scoring system based on six sub-scores (R: renal, U: ureter, B: bladder/outlet, A: abdominal wall, C: cryptorchidism, E: extra-genitourinary, generating the acronym RUBACE), yielding a potential summed score of 0-31. Read More

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August 2018
10 Reads

Benefits of orchidopexy on the fertility of adult men with bilateral cryptorchidism.

Asian J Androl 2018 Nov-Dec;20(6):632-633

Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

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August 2018
3 Reads

Altered miRNA profile in testis of post-cryptorchidopexy patients with non-obstructive azoospermia.

Reprod Biol Endocrinol 2018 Aug 13;16(1):78. Epub 2018 Aug 13.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

Background: Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. MicroRNAs (miRNAs) play vital roles in the progress of spermatogenesis; however, little is known about the miRNA expression profile in the testes. Read More

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August 2018
1 Read

Molecular Mechanisms of Syndromic Cryptorchidism: Data Synthesis of 50 Studies and Visualization of Gene-Disease Network.

Front Endocrinol (Lausanne) 2018 26;9:425. Epub 2018 Jul 26.

Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Cryptorchidism is one of the most frequent congenital birth defects in male children and is present in 2-4% of full-term male births. It has several possible health effects including reduced fertility, increased risk for testicular neoplasia, testicular torsion, and psychological consequences. Cryptorchidism is often diagnosed as comorbid; copresent with other diseases. Read More

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July 2018
7 Reads

A case of spermatocytic seminoma in young individual.

Med J Armed Forces India 2018 Jul 16;74(3):276-279. Epub 2017 Feb 16.

Senior Adviser (Surgery & Oncosurgery), Command Hospital (Air Force), Bangalore, Karnataka 560007, India.

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July 2018
4 Reads