10,988 results match your criteria Cryptococcosis

An opportunity also for comparing rates of tuberculosis/cryptococcosis co-infection.

Oscar M P Jolobe

QJM 2021 Jun 29. Epub 2021 Jun 29.

Flat 6 Souchay Court, 1 Clothorn Road, Manchester, M20 6BR.

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Coinfection of Tuberculosis and Cryptococcosis: A One-two Punch.

QJM 2021 Jun 29. Epub 2021 Jun 29.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Nehru Hospital, 4th floor, F block, Chandigarh, 160012, IndiaAddress:, Sector 12, Chandigarh (India).

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Update on Pulmonary Cryptococcosis.

Mycopathologia 2021 Jun 28. Epub 2021 Jun 28.

Department of Biology, McMaster University, Hamilton, L8S 4K1, Canada.

Pulmonary cryptococcosis is a common but underdiagnosed opportunistic fungal infection in both immunocompromised and immunocompetent patients. The causal agents include at least eight evolutionary distinct haploid lineages as well as their hybrids of the human pathogenic Cryptococcus complex. In this update, we review recent advances in epidemiology, mode of transmission, risk factors, diagnostic methods, and therapy of pulmonary cryptococcosis. Read More

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Lung Masses as a Presenting Sign of Disseminated Cryptococcus.

Cureus 2021 May 22;13(5):e15185. Epub 2021 May 22.

Internal Medicine, University of California Irvine, Orange, USA.

Cryptococcosis is an invasive fungal disease that most commonly affects immunocompromised individuals, typically causing pulmonary and central nervous system (CNS) symptoms. The fungus that causes cryptococcosis, is globally disseminated and often transmitted through bird droppings. The two most frequent and pertinent species responsible for clinical infections in humans include , which has been known to cause the majority of cryptococcosis globally until recently, during which has been identified and reported more frequently. Read More

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Antifungal Combination of Ethyl Acetate Extract of (DC.) L. P. Queiros Stem Bark With Amphotericin B in .

Front Microbiol 2021 10;12:660645. Epub 2021 Jun 10.

Programa de Pós-graduação em Microbiologia, Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.

is the leading cause of cryptococcosis, an invasive and potentially fatal infectious disease. Therapeutic failures are due to the increase in antifungal resistance, the adverse effects of drugs, and the unavailability of therapeutic regimens in low-income countries, which limit the treatment of cryptococcosis, increasing the morbidity and mortality associated with these infections. Thus, new antifungal drugs and innovative strategies for the cryptococcosis treatment are urgently needed. Read More

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Donor-derived Cryptococcus gattii sensu stricto infection in two kidney transplant recipients, southeastern United States.

Am J Transplant 2021 Jun 26. Epub 2021 Jun 26.


Cryptococcus gattii infection is a rare cause of severe pulmonary disease and meningoencephalitis that has only recently been detected in the southeastern United States. We describe organ transplant-associated outbreak of C. gattii infection involving an HIV-negative immunosuppressed donor in this region who died following new-onset headache and seizure of unknown cause. Read More

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Sjögren's syndrome with nervous system injury combined with pulmonary and osseous cryptococcosis: a case report.

J Med Case Rep 2021 Jun 25;15(1):325. Epub 2021 Jun 25.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China.

Background: Sjögren's syndrome is a common autoimmune disease that can involve the nervous system, but rarely both the central and peripheral. Long-term use of high-dose corticosteroids and immunosuppressants are the main risk factors for Cryptococcus infection in patients with Sjögren's syndrome, of which pulmonary infection is the most common, while multiple bone infections are rare.

Case Presentation: A 46-year-old Chinese woman with a 2-year history of Sjögren's syndrome presented to our hospital with numbness of limbs, shortness of breath, and weakness. Read More

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A Spuriously Negative Cryptococcal Antigen Assay Result in Disseminated Cryptococcosis: the Deception of the Postzone Phenomenon.

Ann Clin Lab Sci 2021 May;51(3):430-433

Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

is a basidiomycetous yeast responsible for considerable HIV-related morbidity and mortality. A cachectic 26-year-old HIV-positive man with a CD4 count of 103 cells/μl presented with fever, breathlessness, and bilateral lower limb weakness. A brain computed tomography scan could not elucidate the neurological deficit. Read More

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Cutaneous Hyalophomycosis Caused by Purpureocillium lilacinum in an Autoimmune Hemolytic Anemia Patient with Previous Pulmonary Tuberculosis and Cutaneous Cryptococcosis Infection.

Mycopathologia 2021 Aug 23;186(4):563-564. Epub 2021 Jun 23.

Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, West Lake Rd 38, Hangzhou, 310009, People's Republic of China.

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Fingolimod-related cryptococcal meningoencephalitis and immune reconstitution inflammatory syndrome in a patient with multiple sclerosis.

Mult Scler Relat Disord 2021 Jun 5;53:103072. Epub 2021 Jun 5.

Maxine Mesinger Multiple Sclerosis Comprehensive Care Center, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States.

Fingolimod is an oral medication for multiple sclerosis that sequesters certain subsets of lymphocytes in lymph nodes, reducing egress into blood and their subsequent CNS migration. The initial multi-site randomized Phase III controlled trials found rates of infection similar to those in control groups. However, post-marketing surveillance has revealed an association with several opportunistic infections, including cryptococcosis. Read More

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Serious fungal diseases in Democratic Republic of Congo - Incidence and prevalence estimates.

Mycoses 2021 Jun 16. Epub 2021 Jun 16.

Global Action Fund for Fungal Infections, Geneva, Switzerland.

A literature review was conducted to assess the burden of serious fungal infections in the Democratic Republic of the Congo (DRC) (population 95,326,000). English and French publications were listed and analysed using PubMed/Medline, Google Scholar and the African Journals database. Publication dates spanning 1943-2020 were included in the scope of the review. Read More

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Case Report: A Great Mimicker of Neoplasm: Pulmonary Cryptococcosis in an Immunocompetent Host After High-Altitude Descent.

Am J Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

2Department of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Elmhurst, New York.

Cryptococcus exposure in certain global regions is common and yet virulence in the immunocompetent host remains rare. Radiological findings of pulmonary cryptococcosis may include nonspecific lung nodules or masses indistinguishable from lung cancer or pulmonary tuberculosis. We present a case of an immunocompetent diabetic female who presented with progressively worsening pleuritic chest pain and cough with travel between Tibet and New York 2 months earlier. Read More

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MRI imaging features of HIV-related central nervous system diseases: diagnosis by pattern recognition in daily practice.

Jpn J Radiol 2021 Jun 14. Epub 2021 Jun 14.

Department of Radiology, Osaka University Graduate School of Medicine, 2‑2, Yamadaoka, Suita, Osaka, 565‑0871, Japan.

With the advent of antiretroviral therapy (ART), the prognosis of people infected with human immunodeficiency virus (HIV) has improved, and the frequency of HIV-related central nervous system (CNS) diseases has decreased. Nevertheless, mortality from HIV-related CNS diseases, including those associated with ART (e.g. Read More

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Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient.

Mycopathologia 2021 Aug 11;186(4):507-518. Epub 2021 Jun 11.

Medical Mycology Laboratory, Department of Plant Production and Microbiology, University Miguel Hernández, Campus of Sant Joan D'Alacant, 03550, Alicante, Spain.

Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. Read More

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Primary oral cryptococcosis in an HIV-positive woman with suppressed viral load and normal CD4 count: a rare case.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Medicine, University of the West Indies at Saint Augustine, Saint Augustine, Tunapuna-Piarco, Trinidad and Tobago.

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Identification and assessment of pulmonary Cryptococcus neoformans infection by blood serum surface-enhanced Raman spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 20;260:119978. Epub 2021 May 20.

College of Life and Health Sciences, Northeastern University, Shenyang 110169, China. Electronic address:

Cryptococcus neoformans (C. neoformans) is a causative agent for acute pulmonary infection, which can further develop to lethal meningoencephalitis if untreated. The meningoencephalitis infection can be prevented, if timely treatment on pulmonary cryptococcal infection can be implemented based on its early diagnosis and accurate assessment. Read More

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November 2021

Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009-2019.

J Fungi (Basel) 2021 May 27;7(6). Epub 2021 May 27.

Centre d'Investigation Clinique, Inserm CIC 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana.

Although the burden of histoplasmosis in patients with advanced HIV has been the focus of detailed estimations, knowledge about invasive fungal infections in patients living with HIV in an Amazonian context is somewhat scattered. Our goal was thus to adopt a broader view integrating all invasive fungal infections diagnosed over a decade in French Guiana. All patients hospitalized at Cayenne hospital from 1 January 2009 to 31 December 2018 with a proven diagnosis of invasive fungal infection were included (N = 227). Read More

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The Vacuolar Morphogenesis Protein Vam6-Like Protein Vlp1 Is Required for Pathogenicity of .

J Fungi (Basel) 2021 May 27;7(6). Epub 2021 May 27.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China.

is an encapsulated yeast pathogen that infects immunocompromised patients to cause fungal meningitis, resulting in hundreds of thousands of deaths each year. F-box protein Fbp1, the key component of the E3 ubiquitin ligase, plays a critical role in fungal development and virulence in fungal pathogens. In this study, we identified a potential substrate of Fbp1, the vacuolar morphogenesis protein Vam6-like protein Vlp1, and evaluated its role in virulence in . Read More

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Screening for Cryptococcal Antigenemia and Burden of Cryptococcosis at the Time of HIV Diagnosis: A Retrospective Multicenter Study.

Infect Dis Ther 2021 Sep 29;10(3):1363-1377. Epub 2021 May 29.

Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan.

Introduction: Screening for cryptococcal antigen (CrAg) is recommended for people living with HIV (PLWH) who present with low CD4 lymphocyte counts. Real-world experience is important to identify gaps between the guidelines and clinical practice. We investigated the trends of CrAg testing and prevalence of cryptococcal antigenemia among PLWH at the time of HIV diagnosis and the related mortality in Taiwan from 2009 to 2018. Read More

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September 2021

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of and .

ACS Med Chem Lett 2021 May 7;12(5):774-781. Epub 2021 Apr 7.

Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina 27606, United States.

Opportunistic infections from pathogenic fungi present a major challenge to healthcare because of a very limited arsenal of antifungal drugs, an increasing population of immunosuppressed patients, and increased prevalence of resistant clinical strains due to overuse of the few available antifungals. Cryptococcal meningitis is a life-threatening opportunistic fungal infection caused by one of two species in the genus, and . Eighty percent of cryptococcosis diseases are caused by that is endemic in the environment. Read More

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Examination of a Chinese-made cryptococcal glucuronoxylomannan antigen test in serum and bronchoalveolar lavage fluid for diagnosing pulmonary cryptococcosis in HIV-negative patients.

J Microbiol Immunol Infect 2021 May 15. Epub 2021 May 15.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. Electronic address:

Background: We presented the performance of a Chinese-made cryptococcal glucuronoxylomannan (GXM) antigen test using serum and bronchoalveolar lavage fluid (BALF) samples in the HIV-negative Chinese population.

Methods: Between February 2017 and January 2019, HIV-negative patients with pulmonary cryptococcosis were recruited and followed-up every three months, including completion of a chest CT examination and collection of serum and BALF samples.

Results: Here, thirty-seven confirmed and ten clinically diagnosed patients were recruited. Read More

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A preliminary study on the characteristics of Th1/Th2 immune response in cerebrospinal fluid of AIDS patients with cryptococcal meningitis.

BMC Infect Dis 2021 May 29;21(1):500. Epub 2021 May 29.

Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.

Background: Cryptococcal Meningitis (CM) is a common opportunistic infection in the late stage of acquired immunodeficiency syndrome (AIDS). Despite the wide use of effective antiretroviral and antifungal therapy in AIDS patients, CM is still a major morbidity and mortality cause. Understanding the immune response in cryptococcal infection may help to improve the treatment strategies. Read More

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A Case of Multiple Organ Disseminated Cryptococcosis.

R I Med J (2013) 2021 Jun 1;104(5):44-46. Epub 2021 Jun 1.

Division of Hospital Medicine, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.

Cryptococcus neoformans is an encapsulated yeast found worldwide.1 Patients with immunosuppression, including individuals with HIV/AIDS, transplant recipients and/or individuals with other T-cell mediated immunosuppression are more susceptible to becoming infected with Cryptococcus neoformans than immunocompetent individuals.2 This is a case report of a 66-year-old woman who presented to the emergency department with an unsteady gait and urinary incontinence. Read More

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Clinical characteristics, genotypes, antifungal susceptibility, and outcomes in human immunodeficiency virus-positive patients in Beijing, China.

J Int Med Res 2021 May;49(5):3000605211016197

Department of Clinical Laboratory Medicine, Beijing Ditan Hospital, 12517Capital Medical University, Beijing, P.R. China.

is an environmental fungal pathogen that causes opportunistic infections and severe disseminated meningoencephalitis, mainly in immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS). In this study, the clinical characteristics, treatment protocols, and outcomes of 70 patients with AIDS and infection at Beijing Ditan Hospital were retrospectively analyzed. We performed antimicrobial sensitivity tests and multilocus sequence typing (MLST) on isolates from these patients. Read More

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Changing demographics and risk factors for cryptococcosis: A 12-year review at a tertiary care centre.

Mycoses 2021 May 25. Epub 2021 May 25.

Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.

Background: Cryptococcosis is classically associated with the immunocompromised patients but there is a rising appreciation for its impact on the immunocompetent hosts. We sought to analyse the trends, diagnosis, treatment of different hosts and the effect of immunodeficiency and chronic liver disease on relapse and in-house mortality.

Methods: This is a retrospective study of 12 years of patients with cryptococcosis, divided into three different groups: HIV-infected, transplant and non-HIV non-transplant (NHNT). Read More

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Primary cutaneous cryptococcosis: the importance of early diagnosis.

An Bras Dermatol 2021 Jul-Aug;96(4):482-484. Epub 2021 May 24.

Division of Dermatology, Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.

The species of the Cryptococcus neoformans complex show different epidemiological patterns in the infection of immunosuppressed or immunocompetent individuals, and a common tropism peculiarity for the central nervous system. Primary cutaneous cryptococcosis is a rare clinical entity, with manifestations that are initially restricted to the skin through fungal inoculation, and the absence of systemic disease. The authors report in the present study the case of a 61-year-old immunocompetent man, with a rapidly evolving mucoid tumor on abrasions in contact with bird droppings on the forearm. Read More

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Molecular Markers Reveal Epidemiological Patterns and Evolutionary Histories of the Human Pathogenic .

Front Cell Infect Microbiol 2021 6;11:683670. Epub 2021 May 6.

Department of Biology, McMaster University, Hamilton, ON, Canada.

The human pathogenic species are the main agents of fungal meningitis in humans and the causes of other diseases collectively called cryptococcosis. There are at least eight evolutionary divergent lineages among these agents, with different lineages showing different geographic and/or ecological distributions. In this review, we describe the main strain typing methods that have been used to analyze the human pathogenic and discuss how molecular markers derived from the various strain typing methods have impacted our understanding of not only cryptococcal epidemiology but also its evolutionary histories. Read More

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meningitis in kidney transplant recipients: A diagnostic and therapeutic challenge.

Med Mycol Case Rep 2021 Jun 4;32:84-87. Epub 2021 May 4.

Infectious Diseases Department, APHP, Saint-Louis Hospital, Paris, France.

Cryptococcosis is the third most common invasive fungal infection in solid organ transplant recipients. We describe three cases of neuro-meningeal cryptococcosis occurring among kidney transplant (KT) patients, and discuss the diagnostic and therapeutic challenges in this context. Median time from KT to infection was 6 months [range: 3-9]. Read More

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Cryptococcus neoformans in a child with CSF rhinorrhoea: A cytopathological diagnosis.

Diagn Cytopathol 2021 May 22. Epub 2021 May 22.

Department of Radio-diagnosis, Maulana Azad Medical College, Delhi, India.

Cryptococcosis is caused by Cryptococcus neoformans and is fatal in children. The fungus is known to enter respiratory tract by inhalation and localizes in lungs in immunocompetent host. Patients with immunocompromised state facilitate dissemination of disease. Read More

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