9,963 results match your criteria Cryptococcosis


Clonal Dispersal of VGII in an Endemic Region of Cryptococcosis in Colombia.

J Fungi (Basel) 2019 Apr 15;5(2). Epub 2019 Apr 15.

Microbiology Group, Instituto Nacional de Salud, Bogota 11321, Colombia.

This study characterized the genotype and phenotype of VGII isolates from Cucuta, an endemic region of cryptococcal disease in Colombia, and compared these traits with those from representative isolates from the Vancouver Island outbreak (VGIIa and VGIIb). Genetic diversity was assessed by multilocus sequence typing (MLST) analysis. Phenotypic characteristics, including growth capacity under different temperature and humidity conditions, macroscopic and microscopic morphology, phenotypic switching, mating type, and activity of extracellular enzymes were studied. Read More

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https://www.mdpi.com/2309-608X/5/2/32
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http://dx.doi.org/10.3390/jof5020032DOI Listing
April 2019
1 Read

Disseminated infection in a left ventricular assist device recipient.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

ID, Mayo Clinic, Rochester, Minnesota, USA.

A 51-year-old man with a medical history of coronary artery disease and dyslipidaemia presented with acute myocardial infarction resulting in cardiogenic shock, necessitating intra-aortic balloon pump placement and extracorporeal membrane oxygenation (ECMO). His hospital course was complicated by several infectious complications including ECMO circuit bloodstream infection and presumed infected right atrial thrombus. He subsequently underwent urgent left ventricular assist device placement and had a prolonged hospital stay. Read More

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http://dx.doi.org/10.1136/bcr-2018-228283DOI Listing
April 2019
1 Read

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

First case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina.

Rev Soc Bras Med Trop 2019 Mar 28;52:e20180419. Epub 2019 Mar 28.

Departamento Micología, INEI (Instituto Nacional de Enfermedades Infecciosas) "Dr. Carlos G. Malbrán", ANLIS (Administración Nacional de Laboratorios e Institutos de Salud), Ciudad Autónoma de Buenos Aires, Argentina.

We report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the orotidine monophosphate pyrophosphorylase (URA5) gene as VGIV and identified by multi-locus sequence typing as C. decagattii. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0419-2018DOI Listing
March 2019
4 Reads

Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model.

MBio 2019 04 2;10(2). Epub 2019 Apr 2.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

is an encapsulated fungal pathogen that causes meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our group showed that a mutant lacking the gene encoding sterylglucosidase (Δ) induced protection in both immunocompetent and immunocompromised murine models of cryptococcosis. Read More

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http://dx.doi.org/10.1128/mBio.02909-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445945PMC
April 2019
3 Reads

[Cryptococcal meningoencephalitis in an immunocompetent patient caused by late onset exacerbation].

Rinsho Shinkeigaku 2019 Mar 30. Epub 2019 Mar 30.

Department of Neurology, Dokkyo University Saitama Medical Center.

The case was a 29-year-old male with no previous history of serious disease. He developed headache and fever, which then worsened and he was admitted to our hospital. His temperature was 38. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001250DOI Listing
March 2019
1 Read

[Climate change and systemic fungal infections].

Authors:
Volker Rickerts

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Mar 28. Epub 2019 Mar 28.

FG 16, Erreger von Mykosen, Mykobakteriosen und Parasitosen, Konsiliarlabor für Kryptokokkose und seltene Systemmykosen, Robert Koch-Institut, Seestraße 10, 13353, Berlin, Deutschland.

Background: Climate change may cause profound and complex changes in the prevalence of infectious diseases. Obligate pathogenic fungi causing endemic mycoses and the agents of cryptococcosis are environmental pathogens adapted to environmental niches. They may be exposed to changing climatic conditions, which may change the epidemiology of human infections. Read More

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http://dx.doi.org/10.1007/s00103-019-02931-zDOI Listing
March 2019
1 Read

15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.

PLoS Pathog 2019 03 28;15(3):e1007597. Epub 2019 Mar 28.

Bateson Centre, Firth Court, University of Sheffield, Sheffield, South Yorkshire, United Kingdom.

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438442PMC

Successful Management of Cryptococcal Meningitis and Bone Marrow Infiltration in a Young HIV/AIDS Patient: A Case Report and Review of the Literature.

Case Rep Infect Dis 2019 19;2019:1613072. Epub 2019 Feb 19.

Tufts Medical Center, Infectious Disease, 800 Washington St., Boston, MA 02111, USA.

Bone marrow cryptococcosis has been rarely reported in the literature, and there are no established treatment guidelines specific to this AIDS-related complication. The recommended treatment for AIDS-related invasive fungal treatments include amphotericin B and flucytosine which are associated with an array of complications making optimal treatment recommendations difficult. This case presentation represents an example of a patient with newly diagnosed AIDS and bone marrow cryptococcosis, which was successfully managed with an antifungal regimen adjusted to her comorbidities. Read More

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http://dx.doi.org/10.1155/2019/1613072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399543PMC
February 2019
2 Reads

Cryptococcosis in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Mar 22:e13543. Epub 2019 Mar 22.

VA Portland Healthcare System, Portland, Oregon.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of cryptococcosis in the pre- and post-transplant period. The current update now includes a discussion of cryptococcosis, which is the third most common invasive fungal infection in SOT recipients. Infection often occurs a year after transplantation; however, early infections occur and donor-derived infections have been described within 3 months after transplant. Read More

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http://dx.doi.org/10.1111/ctr.13543DOI Listing
March 2019
1 Read

Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans.

PLoS Pathog 2019 03 21;15(3):e1007627. Epub 2019 Mar 21.

Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Cryptococcus neoformans is a leading cause of invasive fungal infections among immunocompromised patients. However, the cellular constituents of the innate immune response that promote clearance versus progression of infection upon respiratory acquisition of C. neoformans remain poorly defined. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428256PMC

Effect of non-antifungal agrochemicals on the pathogenic fungus Cryptococcus gattii.

Med Mycol 2019 Mar 19. Epub 2019 Mar 19.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

The chemical control of pests and weeds is employed to improve crop production and the quality of agricultural products. The intensive use of pesticides, however, may cause environmental contamination, thus altering microbial communities. Cryptococcus gattii is an environmental yeast and the causative agent of cryptococcosis in both humans and animals. Read More

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http://dx.doi.org/10.1093/mmy/myz018DOI Listing

Isolated Pulmonary Cryptococcosis Confused with Lung Tumor 5 Years After Kidney Transplantation: A Case Report.

Transplant Proc 2019 Mar 12;51(2):561-564. Epub 2018 Dec 12.

Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan.

Background: In transplant recipients, due to the use of immunosuppressive therapy, it is occasionally difficult to distinguish between an infection and malignancy, especially in the case of a lung lesion. Here, we report a case of isolated pulmonary cryptococcosis after kidney transplantation that was difficult to distinguish from a lung tumor.

Case Report: A 52-year-old man underwent a kidney transplant from his mother when he was 44 years old. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.007DOI Listing
March 2019
2 Reads

Idiopathic CD4 lymphopenia in a case of disseminated cryptococcosis with brain, vertebral spine and reproductive organ involvement.

Clin Med (Lond) 2019 Mar;19(2):133-134

Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Cryptococcosis is an opportunistic fungal infection commonly seen in HIV cases. We present a case of disseminated cryptococcosis with multiple non-continuous infective foci in a non-HIV, non-transplant case. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-2-133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454367PMC
March 2019
1 Read

Severe clinical immunodeficiency in a patient with human immunodeficiency virus infection and relatively high CD4 counts: a case report.

J Med Case Rep 2019 Mar 14;13(1):86. Epub 2019 Mar 14.

Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.

Background: The coexistence of neuromeningeal cryptococcosis and Kaposi's sarcoma is not surprising in a patient with human immunodeficiency virus infection and a low CD4 count, although it is rarely described. However, we describe such an association in a patient with human immunodeficiency virus infection and a relatively high CD4 count.

Case Presentation: A 41-year old Cameroonian woman presented to our hospital with subacute occipital headaches associated with photophobia, blurred vision, phonophobia, projectile vomiting, and tonic seizures. Read More

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http://dx.doi.org/10.1186/s13256-019-1982-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417181PMC
March 2019
1 Read

Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil.

Emerg Microbes Infect 2019 ;8(1):119-129

b Division of Infectious Disease, Department of Medicine , Duke University School of Medicine , Durham , NC , USA.

Genotypic diversity and fluconazole susceptibility of 82 Cryptococcus neoformans and Cryptococcus gattii isolates from 60 renal transplant recipients in Brazil were characterized. Clinical characteristics of the patients and prognostic factors were analysed. Seventy-two (87. Read More

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http://dx.doi.org/10.1080/22221751.2018.1562849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455115PMC
January 2019
1 Read

A Multicenter, Longitudinal Cohort Study of Cryptococcosis in HIV-Negative People in the United States.

Clin Infect Dis 2019 Mar 11. Epub 2019 Mar 11.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Background: Cryptococcosis is increasingly recognized in people without HIV.

Methods: A multicenter, prospective cohort study was performed in 25 U.S. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz193DOI Listing
March 2019
11 Reads

Cryptococcus gattii VGII isolated from native forest and river in Northern Brazil.

Braz J Microbiol 2019 Mar 9. Epub 2019 Mar 9.

Laboratório de Micologia Médica, Instituto Nacional de Pesquisas da Amazônia, Av. André Araújo, 2936, Aleixo, Manaus, AM, 69060-001, Brazil.

Background: Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. In the northern region of Brazil, this disease is caused by Cryptococcus neoformans genotype VNI and Cryptococcus gattii genotype VGII. However, few environmental studies have been conducted in this large tropical area. Read More

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http://dx.doi.org/10.1007/s42770-019-00066-6DOI Listing
March 2019
1 Read

[Cerebral cryptococcosis and immune reconstitution inflammatory syndrome. Case report].

Rev Med Chil 2018 Dec;146(12):1481-1485

Subdepartamento de Medicina, Hospital Base de Valdivia, Valdivia, Chile.

We report a 45-year-old male with AIDS who had a Cryptococcus neoformans central nervous system infection. He was treated with amphotericin B deoxycholate subsequently changed to voriconazole due to systemic toxicity of the former. Plasma levels of voriconazole were insufficient with a standard dose (0. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201481DOI Listing
December 2018
10 Reads

The mouse inhalation model of infection recapitulates strain virulence in humans and shows closely related strains can possess differential virulence.

Infect Immun 2019 Mar 4. Epub 2019 Mar 4.

Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN

Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet factors influencing patient outcome are not well understood. Pathogen-specific traits, such as the strain genotype and degree of antigen shedding, are associated with clinical outcome but the underlying biology remains elusive. In this study, we examined factors determining disease outcome in HIV-infected cryptococcal meningitis patients infected with strains with the same multi-locus sequence type (MLST). Read More

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http://dx.doi.org/10.1128/IAI.00046-19DOI Listing

Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report.

BMC Infect Dis 2019 Mar 4;19(1):220. Epub 2019 Mar 4.

Department of Infectious Diseases, Hospital Giselda Trigueiro, Universidade Federal do Rio Grande do Norte, 110 Cônego Monte Street, Natal, Rio Grande do Norte, RN 59037-170, Brazil.

Background: Cryptococcosis is a common opportunistic infection in patients infected by Human Immunodeficiency Virus (HIV) and is the second leading cause of mortality in Acquired Immunodeficiency Syndrome (AIDS) patients worldwide. The most frequent presentation of cryptococcal infection is subacute meningitis, especially in patients with a CD4+ T Lymphocytes count below 100 cells/μL. However, in severely immunosuppressed individuals Cryptococcus neoformans can infect virtually any human organ, including the bone marrow, which is a rare presentation of cryptococcosis. Read More

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http://dx.doi.org/10.1186/s12879-019-3831-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399886PMC
March 2019
4 Reads

Screening and Antifungal Activity of a -Carboline Derivative against and .

Int J Microbiol 2019 22;2019:7157845. Epub 2019 Jan 22.

Instituto Nacional de Pesquisas da Amazônia, Manaus, Amazonas, Brazil.

Background: Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment. The aim of this study was to investigate the medicinal potential of carbazole and -carboline alkaloids and derivatives against and .

Methods: MICs were established in accordance with the recommendations of the Clinical and Laboratory Standards Institute for alkaloids and derivatives against and genotypes VNI and VGI, respectively. Read More

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http://dx.doi.org/10.1155/2019/7157845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362477PMC
January 2019
2 Reads

A Surgical Case of Inflammatory Myofibroblastic Tumor of the Liver: Potentially Characteristic Gross Features.

Clin Med Insights Oncol 2019 12;13:1179554919829498. Epub 2019 Feb 12.

Department of Surgery, National Hospital Organization, Fukuyama Medical Center, Fukuyama, Japan.

We herein reported a very rare surgical case of inflammatory myofibroblastic tumor (IMT) of the liver, showing potentially unique and specific gross findings on its cut surface: our IMT demonstrated a relatively well-demarcated and partly infiltrative and likely extrahepatic (ie serosal) but not intrahepatic mass, appearing firm and hemorrhagic, and yellow-whitish in color. The patient, who was a woman in her early 70s with 2-year follow-up for lung cryptococcosis and traffic accident, incidentally presented with unenhanced and low-density, heterogeneous mass on abdominal dynamic CT in the peripheral right lobe of the liver. We could conclusively diagnose the current lesion as the hepatic IMT after thorough analyses including a wide panel of immunohistochemical antibodies. Read More

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http://dx.doi.org/10.1177/1179554919829498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378515PMC
February 2019
1 Read

Clostridioides difficile-related toxic megacolon after Cryptococcus neoformans cellulitis: A complex of two rare infections in an immunocompromised host.

J Infect Chemother 2019 May 21;25(5):379-384. Epub 2019 Feb 21.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Nagakute, Aichi, Japan. Electronic address:

A 76-year-old Japanese woman was admitted due to uncontrolled cellulitis of the right lower leg. She had deep vein thrombosis on the right limb. Moreover, she had a long history of rheumatoid arthritis treated with corticosteroids. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.003DOI Listing
May 2019
6 Reads

The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency.

PLoS One 2019 21;14(2):e0212651. Epub 2019 Feb 21.

Centre for Infectious Diseases and Microbiology, Fungal Pathogenesis Group, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.

The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of genes controlling the acquisition of phosphate from both external and cellular sources. One such gene, BTA1, is highly up-regulated during phosphate starvation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212651PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383925PMC
February 2019
1 Read

An Unusual Case of Pulmonary Cryptococcus.

Cureus 2018 Dec 8;10(12):e3707. Epub 2018 Dec 8.

Internal Medicine, Seton Hall University-Hackensack Meridian School of Medicine, St. Francis Program, Trenton, USA.

Cryptococcal infections are caused by encapsulated fungi Cryptococcus gattii and C. neoformans. Inhalation commonly causes innocuous colonization but may cause meningitis or disseminated disease via hematogenous spread. Read More

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http://dx.doi.org/10.7759/cureus.3707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372251PMC
December 2018

Gastric cryptococcosis: an unusual presentation of a common opportunistic disorder.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e10. Epub 2019 Feb 14.

Universidade Federal do Estado do Rio de Janeiro, Centro de Ciências Biológicas e da Saúde, Hospital Universitário Gaffrée e Guinle, 10ª Enfermaria, Rio de Janeiro, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1590/S1678-9946201961010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376925PMC
February 2019
1 Read

An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System.

Curr Protoc Microbiol 2019 Feb 18:e78. Epub 2019 Feb 18.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri.

Cryptococcus neoformans is an environmental yeast found worldwide that causes lethal brain infections, particularly in immunocompromised hosts. In 2016, there were 280,000 cases of cryptococcal meningitis in the HIV+ population, two-thirds of them fatal; other immunocompromised patients are also affected. The burden of cryptococcal disease and the limits of current chemotherapy create a pressing need for improved treatment. Read More

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http://dx.doi.org/10.1002/cpmc.78DOI Listing
February 2019
1 Read

In vitro combination between antifungals and diphenyl diselenide against Cryptococcus species.

Mycoses 2019 Feb 18. Epub 2019 Feb 18.

Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Cryptococcus species are an encapsulated fungal pathogen that cause cryptococcal meningitis. There are limited therapeutic options for this infection. The management includes the use of different antifungals such as amphotericin B, flucytosine, or fluconazole, either alone or in combination. Read More

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http://dx.doi.org/10.1111/myc.12905DOI Listing
February 2019
1 Read
1.805 Impact Factor

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018
1 Read

A Case of Intramuscular Cryptococcosis Mimicking a Malignant Tumor on FDG PET/CT.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

PET/CT, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Intramuscular cryptococcosis is extremely rare. In this case, a 76-year-old man with history of acute myeloid leukemia presented a painful mass in the right upper arm. FDG PET/CT demonstrated a low-density irregular-shaped mass in the triceps muscle of the right upper arm with adjacent bone erosion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002488DOI Listing
February 2019
1 Read

Resistance and Tolerance to Cryptococcal Infection: An Intricate Balance That Controls the Development of Disease.

Front Immunol 2019 29;10:66. Epub 2019 Jan 29.

Translational Research in Respiratory Diseases Program, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

is a ubiquitous environmental yeast and a leading cause of invasive fungal infection in humans. The most recent estimate of global disease burden includes over 200,000 cases of cryptococcal meningitis each year. expresses several virulence factors that may have originally evolved to protect against environmental threats, and human infection may be an unintended consequence of these acquired defenses. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361814PMC
January 2019
1 Read

Cryptococcal Meningitis in a HIV-Negative Patient.

Eur J Case Rep Intern Med 2018 22;5(2):000778. Epub 2018 Feb 22.

Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal.

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. Read More

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http://dx.doi.org/10.12890/2017_000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346933PMC
February 2018
1 Read

Cdk8 and Ssn801 Regulate Oxidative Stress Resistance and Virulence in Cryptococcus neoformans.

MBio 2019 02 12;10(1). Epub 2019 Feb 12.

Department of Molecular Microbiology, Washington University School of Medicine, Washington University, St. Louis, Missouri, USA

kills 200,000 people worldwide each year. After inhalation, this environmental yeast proliferates either extracellularly or within host macrophages. Under conditions of immunocompromise, cryptococci disseminate from the lungs to the brain, causing a deadly meningoencephalitis that is difficult and expensive to treat. Read More

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http://dx.doi.org/10.1128/mBio.02818-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372802PMC
February 2019
1 Read

VGIIa Infection Associated with Travel to the Pacific Northwest Outbreak Region in an Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibody-Positive Patient in the United States.

MBio 2019 02 12;10(1). Epub 2019 Feb 12.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

The region encompassing the Pacific Northwest (PNW), Vancouver Island, Oregon, and Washington has been the location of an ongoing outbreak since the 1990s, and there is evidence that the outbreak is expanding along the West Coast into California. Here we report a clinical case of a 69-year-old, HIV-negative man from North Carolina who was diagnosed with a fungal brain mass by magnetic resonance imaging (MRI) and pathology. He had traveled to Seattle and Vancouver 3 years earlier and to Costa Rica 4 months prior to presentation. Read More

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http://dx.doi.org/10.1128/mBio.02733-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372798PMC
February 2019
5 Reads

Disseminated cryptococcosis with immunoglobulin G subclass deficiency.

Pediatr Int 2019 Feb 11;61(2):198-199. Epub 2019 Feb 11.

Division of Pediatric Infectious Disease, Department of Pediatrics, St Joseph's Children's Hospital, Paterson, New Jersey, USA.

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http://dx.doi.org/10.1111/ped.13741DOI Listing
February 2019
7 Reads

Characterization of the 6-O-acetylated lipoglucuronomannogalactan a novel Cryptococcus neoformans cell wall polysaccharide.

Carbohydr Res 2019 Mar 29;475:1-10. Epub 2019 Jan 29.

Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21942-902, Brazil. Electronic address:

Glucuronoxylomannogalactans (GXMGals) are characteristic capsular polysaccharides produced by the opportunistic fungus C. neoformans, which are implicated in cryptococcal virulence, via impairment of the host immune response. We determined for the first time the structure of a lipoglucuronomannogalactan (LGMGal), isolated from the surface of a mutant C. Read More

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http://dx.doi.org/10.1016/j.carres.2019.01.012DOI Listing
March 2019
3 Reads

Drug development for cryptococcosis treatment: what can patents tell us?

Mem Inst Oswaldo Cruz 2019 Jan 31;114:e180391. Epub 2019 Jan 31.

Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Ciência e Tecnologia de Gestão da Inovação em Doenças Negligenciadas, Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, RJ, Brasil.

Background: Cryptococcosis is one of the most devastating fungal infections in humans. Despite the disease's clinical importance, current therapy is based on limited antifungals that are either toxic, inefficient, unavailable worldwide, or that quickly lead to resistance.

Objectives: The goal of this study was to provide insight into the future of cryptococcosis treatment by describing the patent scenario in this field. Read More

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http://dx.doi.org/10.1590/0074-02760180391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358010PMC
January 2019
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The Diagnostic Challenge of an Infrequent Spectrum of Infection.

Case Rep Radiol 2019 2;2019:5970648. Epub 2019 Jan 2.

MD, Radiologist, Department of Radiology of the Medical School of the University of São Paulo, São Paulo, SP, Brazil.

Cryptococcal infection results from inhalation of fungal spores and usually is confined to the lungs, but may disseminate systemically. Radiologically, cryptococcal infection has multiple forms of presentation. The diagnosis is usually based on fungal isolation from cultured clinical specimens. Read More

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http://dx.doi.org/10.1155/2019/5970648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334315PMC
January 2019
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Development of a lateral flow recombinase polymerase amplification assay for rapid and visual detection of Cryptococcus neoformans/C. gattii in cerebral spinal fluid.

BMC Infect Dis 2019 Feb 4;19(1):108. Epub 2019 Feb 4.

Clinical Laboratory, Shenzhen Third People's Hospital, No.29 Bulan Road, Shenzhen, 518112, Guangdong, China.

Background: For definitive diagnosis of cryptococcal meningitis, Cryptococcus neoformans and/or C. gattii must be identified within cerebral spinal fluid from the patients. The traditional methods for detecting Cryptococcus spp. Read More

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http://dx.doi.org/10.1186/s12879-019-3744-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360735PMC
February 2019
2 Reads

A Large Deep Skin Ulcer as an Initial Manifestation of Systemic Cryptococcosis.

Mycopathologia 2019 Feb 1. Epub 2019 Feb 1.

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami, Hiroshima, 734-8551, Japan.

An 82-year-old woman presented to our hospital with a deep skin ulcer in her right lower limb. Although the skin biopsy showed necrosis and neutrophil infiltration, we could not initially detect any pathogen. Chest radiography showed multiple nodules despite the lack of respiratory symptoms or fever, and the serum latex agglutination test for cryptococcus showed an elevated titer (1:512). Read More

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http://dx.doi.org/10.1007/s11046-019-00322-1DOI Listing
February 2019
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Disseminated Cryptococcosis After Liver Transplant: A Case Report.

Exp Clin Transplant 2019 Jan 29. Epub 2019 Jan 29.

From the Hepatology Department of Internal Medicine, Universidad de Antioquia, Medellín, Colombia.

Cryptococcosis is an opportunistic infection caused by the Basidiomycota Cryptococcus neoformans (Cryptococcus gattii), which affects immunosuppressed patients and less frequently immunocompetent patients. Solid-organ transplant recipients are a particularly high-risk group, depending on the net state of immunosuppression. In these patients, the infection usually appears after the first year after transplant, although it may occur earlier in liver transplant recipients. Read More

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http://dx.doi.org/10.6002/ect.2018.0051DOI Listing
January 2019
3 Reads

Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis.

Case Reports Hepatol 2018 31;2018:5174518. Epub 2018 Dec 31.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, 611-0042, Japan.

Diagnosis of invasive cryptococcal infection in apparently nonimmunocompromised patients is difficult and often delayed. Human immunodeficiency virus- (HIV-) negative patients with decompensated hepatic cirrhosis might be at high risk of cryptococcal infection. We report here an 82-year-old Japanese female with end-stage hepatic failure and undergoing renal dialysis, hospitalized with septic shock-like symptoms. Read More

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http://dx.doi.org/10.1155/2018/5174518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333006PMC
December 2018
6 Reads

Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients.

Eur J Clin Microbiol Infect Dis 2019 Apr 25;38(4):735-741. Epub 2019 Jan 25.

Departments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

There have been conflicting reports of false positive galactomannan assay results in patients with systemic cryptococcosis. We sought to determine the frequency of GM positivity in patients with pulmonary cryptococcosis and confirm the source of this cross-reactivity in vitro. We conducted a retrospective study to elucidate the rate of galactomannan (GM) false positivity and cause in a cohort of 29 patients with pulmonary cryptococcal disease. Read More

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http://link.springer.com/10.1007/s10096-019-03469-3
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http://dx.doi.org/10.1007/s10096-019-03469-3DOI Listing
April 2019
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Amino acid permeases in Cryptococcus neoformans are required for high temperature growth and virulence; and are regulated by Ras signaling.

PLoS One 2019 25;14(1):e0211393. Epub 2019 Jan 25.

Universidade Federal de São Paulo, Campus Diadema, Department of Biological Sciences, Diadema, SP, Brazil.

Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in immunocompromised patients. Therapeutic failure due to pathogen drug resistance, treatment inconstancy and few antifungal options is a problem. The study of amino acid biosynthesis and uptake represents an opportunity to explore possible development of novel antifungals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211393PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347259PMC
January 2019
2 Reads

Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity.

Ann Otol Rhinol Laryngol 2019 May 24;128(5):472-479. Epub 2019 Jan 24.

1 Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: Describe the demographics and clinical manifestations of laryngeal cryptococcosis. Develop a simple approach to the diagnostic workup and treatment of localized laryngeal cryptococcal infection.

Methods: A new case of laryngeal cryptococcosis encountered at our institution is presented and placed in context of the literature surrounding prior reported cases. Read More

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http://dx.doi.org/10.1177/0003489419826131DOI Listing
May 2019
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A Glucuronoxylomannan Epitope Exhibits Serotype-Specific Accessibility and Redistributes towards the Capsule Surface during Titanization of the Fungal Pathogen Cryptococcus neoformans.

Infect Immun 2019 Apr 25;87(4). Epub 2019 Mar 25.

Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom

Disseminated infections with the fungal species or, less frequently, are an important cause of mortality in immunocompromised individuals. Central to the virulence of both species is an elaborate polysaccharide capsule that consists predominantly of glucuronoxylomannan (GXM). Due to its abundance, GXM is an ideal target for host antibodies, and several monoclonal antibodies (mAbs) have previously been derived using purified GXM or whole capsular preparations as antigens. Read More

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http://dx.doi.org/10.1128/IAI.00731-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434129PMC
April 2019
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Neutrophil-mediated antifungal activity against highly virulent Cryptococcus gattii strain R265.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Vaccine-induced immune responses, including neutrophil, macrophage, and T-cell responses, ameliorate cryptococcosis caused by Cryptococcus gattii. However, whether neutrophils can exert fungicidal activity against C. gattii remains to be elucidated. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy153DOI Listing
January 2019
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Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
4 Reads

Silkworm as an experimental animal for research on fungal infections.

Microbiol Immunol 2019 Feb 14;63(2):41-50. Epub 2019 Feb 14.

Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192-0395, Japan.

Silkworm, Bombyx mori, has various advantages as an experimental animal, such as the low cost for rearing and fewer ethical problems. Models utilizing silkworms of infection with pathogenic bacteria have been established for identification of genes encoding virulence factors by large-scale in vivo screening. In this review, we describe recent progress in the study of silkworm infection models for elucidating the mechanisms of fungi infection. Read More

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http://doi.wiley.com/10.1111/1348-0421.12668
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http://dx.doi.org/10.1111/1348-0421.12668DOI Listing
February 2019
9 Reads