9,905 results match your criteria Cryptococcosis


[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018

A Case of Intramuscular Cryptococcosis Mimicking a Malignant Tumor on FDG PET/CT.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

PET/CT, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Intramuscular cryptococcosis is extremely rare. In this case, a 76-year-old man with history of acute myeloid leukemia presented a painful mass in the right upper arm. FDG PET/CT demonstrated a low-density irregular-shaped mass in the triceps muscle of the right upper arm with adjacent bone erosion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002488DOI Listing
February 2019

Resistance and Tolerance to Cryptococcal Infection: An Intricate Balance That Controls the Development of Disease.

Front Immunol 2019 29;10:66. Epub 2019 Jan 29.

Translational Research in Respiratory Diseases Program, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

is a ubiquitous environmental yeast and a leading cause of invasive fungal infection in humans. The most recent estimate of global disease burden includes over 200,000 cases of cryptococcal meningitis each year. expresses several virulence factors that may have originally evolved to protect against environmental threats, and human infection may be an unintended consequence of these acquired defenses. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361814PMC
January 2019

Cryptococcal Meningitis in a HIV-Negative Patient.

Eur J Case Rep Intern Med 2018 22;5(2):000778. Epub 2018 Feb 22.

Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal.

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. Read More

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http://dx.doi.org/10.12890/2017_000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346933PMC
February 2018

Disseminated cryptococcosis with immunoglobulin G subclass deficiency.

Pediatr Int 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Infectious Disease, Department of Pediatrics, St Joseph's Children's Hospital, Paterson, New Jersey, USA.

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http://dx.doi.org/10.1111/ped.13741DOI Listing
February 2019
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Characterization of the 6-O-acetylated lipoglucuronomannogalactan a novel Cryptococcus neoformans cell wall polysaccharide.

Carbohydr Res 2019 Jan 29;475:1-10. Epub 2019 Jan 29.

Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21942-902, Brazil. Electronic address:

Glucuronoxylomannogalactans (GXMGals) are characteristic capsular polysaccharides produced by the opportunistic fungus C. neoformans, which are implicated in cryptococcal virulence, via impairment of the host immune response. We determined for the first time the structure of a lipoglucuronomannogalactan (LGMGal), isolated from the surface of a mutant C. Read More

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http://dx.doi.org/10.1016/j.carres.2019.01.012DOI Listing
January 2019

Drug development for cryptococcosis treatment: what can patents tell us?

Mem Inst Oswaldo Cruz 2019 Jan 31;114:e180391. Epub 2019 Jan 31.

Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Ciência e Tecnologia de Gestão da Inovação em Doenças Negligenciadas, Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, RJ, Brasil.

Background: Cryptococcosis is one of the most devastating fungal infections in humans. Despite the disease's clinical importance, current therapy is based on limited antifungals that are either toxic, inefficient, unavailable worldwide, or that quickly lead to resistance.

Objectives: The goal of this study was to provide insight into the future of cryptococcosis treatment by describing the patent scenario in this field. Read More

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http://dx.doi.org/10.1590/0074-02760180391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358010PMC
January 2019

The Diagnostic Challenge of an Infrequent Spectrum of Infection.

Case Rep Radiol 2019 2;2019:5970648. Epub 2019 Jan 2.

MD, Radiologist, Department of Radiology of the Medical School of the University of São Paulo, São Paulo, SP, Brazil.

Cryptococcal infection results from inhalation of fungal spores and usually is confined to the lungs, but may disseminate systemically. Radiologically, cryptococcal infection has multiple forms of presentation. The diagnosis is usually based on fungal isolation from cultured clinical specimens. Read More

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http://dx.doi.org/10.1155/2019/5970648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334315PMC
January 2019

A Large Deep Skin Ulcer as an Initial Manifestation of Systemic Cryptococcosis.

Mycopathologia 2019 Feb 1. Epub 2019 Feb 1.

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami, Hiroshima, 734-8551, Japan.

An 82-year-old woman presented to our hospital with a deep skin ulcer in her right lower limb. Although the skin biopsy showed necrosis and neutrophil infiltration, we could not initially detect any pathogen. Chest radiography showed multiple nodules despite the lack of respiratory symptoms or fever, and the serum latex agglutination test for cryptococcus showed an elevated titer (1:512). Read More

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http://dx.doi.org/10.1007/s11046-019-00322-1DOI Listing
February 2019
1 Read

Disseminated Cryptococcosis After Liver Transplant: A Case Report.

Exp Clin Transplant 2019 Jan 29. Epub 2019 Jan 29.

From the Hepatology Department of Internal Medicine, Universidad de Antioquia, Medellín, Colombia.

Cryptococcosis is an opportunistic infection caused by the Basidiomycota Cryptococcus neoformans (Cryptococcus gattii), which affects immunosuppressed patients and less frequently immunocompetent patients. Solid-organ transplant recipients are a particularly high-risk group, depending on the net state of immunosuppression. In these patients, the infection usually appears after the first year after transplant, although it may occur earlier in liver transplant recipients. Read More

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http://dx.doi.org/10.6002/ect.2018.0051DOI Listing
January 2019
2 Reads

Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis.

Case Reports Hepatol 2018 31;2018:5174518. Epub 2018 Dec 31.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, 611-0042, Japan.

Diagnosis of invasive cryptococcal infection in apparently nonimmunocompromised patients is difficult and often delayed. Human immunodeficiency virus- (HIV-) negative patients with decompensated hepatic cirrhosis might be at high risk of cryptococcal infection. We report here an 82-year-old Japanese female with end-stage hepatic failure and undergoing renal dialysis, hospitalized with septic shock-like symptoms. Read More

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http://dx.doi.org/10.1155/2018/5174518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333006PMC
December 2018
4 Reads

Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients.

Eur J Clin Microbiol Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Departments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

There have been conflicting reports of false positive galactomannan assay results in patients with systemic cryptococcosis. We sought to determine the frequency of GM positivity in patients with pulmonary cryptococcosis and confirm the source of this cross-reactivity in vitro. We conducted a retrospective study to elucidate the rate of galactomannan (GM) false positivity and cause in a cohort of 29 patients with pulmonary cryptococcal disease. Read More

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http://link.springer.com/10.1007/s10096-019-03469-3
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http://dx.doi.org/10.1007/s10096-019-03469-3DOI Listing
January 2019
5 Reads

Amino acid permeases in Cryptococcus neoformans are required for high temperature growth and virulence; and are regulated by Ras signaling.

PLoS One 2019 25;14(1):e0211393. Epub 2019 Jan 25.

Universidade Federal de São Paulo, Campus Diadema, Department of Biological Sciences, Diadema, SP, Brazil.

Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in immunocompromised patients. Therapeutic failure due to pathogen drug resistance, treatment inconstancy and few antifungal options is a problem. The study of amino acid biosynthesis and uptake represents an opportunity to explore possible development of novel antifungals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211393PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347259PMC
January 2019
1 Read

Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity.

Ann Otol Rhinol Laryngol 2019 Jan 24:3489419826131. Epub 2019 Jan 24.

1 Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives:: Describe the demographics and clinical manifestations of laryngeal cryptococcosis. Develop a simple approach to the diagnostic workup and treatment of localized laryngeal cryptococcal infection.

Methods:: A new case of laryngeal cryptococcosis encountered at our institution is presented and placed in context of the literature surrounding prior reported cases. Read More

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http://dx.doi.org/10.1177/0003489419826131DOI Listing
January 2019

A glucuronoxylomannan epitope exhibits serotype-specific accessibility and redistributes towards the capsule surface during Titanisation of the fungal pathogen .

Infect Immun 2019 Jan 22. Epub 2019 Jan 22.

Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. B15 2TT

Disseminated infections with the fungal species or, less frequently, , are an important cause of mortality in immunocompromised individuals. Central to the virulence of both species is an elaborate polysaccharide capsule that consists predominantly of glucuronoxylomannan (GXM). Due to its abundance, GXM is an ideal target for host antibodies, and several monoclonal antibodies (mAbs) have previously been derived using purified GXM or whole capsular preparations as antigen. Read More

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http://dx.doi.org/10.1128/IAI.00731-18DOI Listing
January 2019

Neutrophil-mediated antifungal activity against highly virulent Cryptococcus gattii strain R265.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Vaccine-induced immune responses, including neutrophil, macrophage, and T-cell responses, ameliorate cryptococcosis caused by Cryptococcus gattii. However, whether neutrophils can exert fungicidal activity against C. gattii remains to be elucidated. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy153DOI Listing
January 2019
7 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
1 Read

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
2 Reads

Screening of natural lead molecules against putative molecular targets of drug resistant Cryptococcus spp: an insight from computer aided molecular design.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

Department of Biotechnology Engineering, Dayananda Sagar Institutions, Bengaluru, Karnataka, 560 078, Visvesvaraya Technological University. India.

Cryptococcosis is one of the major invasive fungal infections distributed worldwide with high mortality rate. C. neoformans and C. Read More

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http://dx.doi.org/10.2174/1568026619666190119145434DOI Listing
January 2019
3 Reads

Comparative antifungal susceptibility analyses of Cryptococcus neoformans VNI and Cryptococcus gattii VGII from the Brazilian Amazon Region by the Etest, Vitek 2, and the Clinical and Laboratory Standards Institute broth microdilution methods.

Med Mycol 2019 Jan 17. Epub 2019 Jan 17.

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, INI/Fiocruz, Rio de Janeiro, RJ.

Early diagnosis, efficient clinical support, and proper antifungal therapy are essential to reduce death and sequels caused by cryptococcosis. The emergence of resistance to the antifungal drugs commonly used for cryptococcosis treatment is an important issue of concern. Thus, the in vitro antifungal susceptibility of clinical strains from northern Brazil, including C. Read More

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http://dx.doi.org/10.1093/mmy/myy150DOI Listing
January 2019
1 Read

Prevalence of cryptococcal antigenemia and nasal colonization in a free-ranging koala population.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

Sydney School of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia.

Cryptococcosis, caused by environmental fungi in the Cryptococcus neoformans and Cryptococcus gattii species complexes, affects a variety of hosts, including koalas (Phascolarctos cinereus). Cryptococcal antigenemia and nasal colonization are well characterized in captive koalas, but free-ranging populations have not been studied systematically. Free-ranging koalas (181) from the Liverpool Plains region of New South Wales, Australia, were tested for cryptococcal antigenemia (lateral flow immunoassay) and nasal colonization (bird seed agar culture). Read More

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http://dx.doi.org/10.1093/mmy/myy144DOI Listing
January 2019

Cryptococcosis-associated Immune Reconstitution Inflammatory Syndrome is associated with Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T-cells and Monocyte Activation.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Africa Health Research Institute (AHRI), Durban, South Africa.

Background: Systemic levels of interleukin (IL)-7 at antiretroviral therapy (ART) initiation have previously been shown to be predictive of HIV-linked paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). We therefore explored IL-7/IL-7 receptor (IL-7/IL-7R) signaling pathway dysfunction, with related alterations in immune function, as a mechanism underlying C-IRIS.

Method: HIV-infected patients with cryptococcal meningitis (CM) who experienced C-IRIS (n=27) were compared to CD4+ T-cell count-matched counterparts without C-IRIS (n=27), following antifungal therapy and pre-ART initiation. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001946DOI Listing
January 2019
3 Reads

Genetic Diversity of the Cryptococcus gattii Species Complex in Mato Grosso State, Brazil.

Mycopathologia 2019 Feb 9;184(1):45-51. Epub 2019 Jan 9.

Postgraduate Course in Veterinary Sciences, Department of Veterinary Sciences, Federal University of Mato Grosso, Cuiabá, Brazil.

Cryptococcosis is caused by fungi of the genus Cryptococcus. Owing to its importance, this study aimed to analyze the genetic diversity of C. gattii isolates from animals, humans, and the environment in Mato Grosso State (MT), Brazil, during November 2010-December 2017. Read More

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http://dx.doi.org/10.1007/s11046-018-0313-2DOI Listing
February 2019

Magnitude of Cryptococcal Antigenemia among HIV Infected Patients at a Referral Hospital, Northwest Ethiopia.

Ethiop J Health Sci 2018 Jul;28(4):369-374

Department of Epidemiology and Biostatstics, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Cryptococcosis is one of the common opportunistic fungal infections among HIV infected patients living in Sub-Saharan Africa, including Ethiopia. The magnitude of the disease at Felege Hiwot Referral Hospital (FHRH) in particular and in Ethiopia at large is not well explored.

Methods: A retrospective document review and analysis was done on records of 137 HIV infected patients who visited FHRH ART clinic from 1 Sep to 30 Dec 2016 and had registered data on their sex, age, CD4 count and cryptococcal antigen screening result. Read More

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http://dx.doi.org/10.4314/ejhs.v28i4.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308728PMC
July 2018
3 Reads

CRYPTOCOCCAL meningitis in a HIV negative newly diagnosed diabetic patient: a CASE report.

BMC Infect Dis 2019 Jan 3;19(1). Epub 2019 Jan 3.

School of Medicine, Department of Family Medicine, Moi University, P. O. Box, Eldoret, 3900-30100, Kenya.

Background: This case report emphasizes the need to recognize cryptococcus as a possible cause of meningitis in non-HIV patients in Sub-Saharan Africa and to highlight the possibility of grave outcomes due to the paradoxical immune response in diabetic patients with cryptococcus meningitis. It also highlights the need for widespread availability of amphotericin-B and flucytosine in hospitals in Sub-Saharan Africa.

Case Presentation: A 27 year old African lady was admitted with generalized tonic clonic seizures lasting 5 to 10 min. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3625-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318972PMC
January 2019
8 Reads

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality.

PLoS One 2018 31;13(12):e0209337. Epub 2018 Dec 31.

Division of Biostatistics, School of Public Health, University of Minnesota, Minnesota, Minneapolis, United States of America.

Background: The mortality from cryptococcal meningitis remains high, despite the availability of antiretroviral therapy (ART) and amphotericin-based fungal regimens. The role of neutrophils in cryptococcosis is controversial. Our objective was to examine the association between blood neutrophil counts and outcomes in terms of mortality, the incidence of bacterial infections (including Mycobacterium tuberculosis) and hospitalization among HIV-infected patients presenting with cryptococcal meningitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312212PMC
December 2018
3.234 Impact Factor

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report.

BMC Infect Dis 2018 Dec 27;18(1):704. Epub 2018 Dec 27.

Medical student, Universidad Tecnológica de Pereira, Pereira, Colombia.

Background: Those infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307277PMC
December 2018
5 Reads

Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report.

BMC Infect Dis 2018 Dec 27;18(1):693. Epub 2018 Dec 27.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

Background: Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic and therapeutic management.

Case Presentation: A 35-year-old male with a history of fever and back pain. Read More

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http://dx.doi.org/10.1186/s12879-018-3573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307234PMC
December 2018
4 Reads

A Comparison of the Clinical Characteristics and Outcomes of Cryptococcal Meningitis in HIV-negative Individuals With and Without Immunosuppression.

Neurologist 2019 Jan;24(1):1-5

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Cryptococcal meningitis (CM) is found to occur in immunosuppressed patients and those who are immunocompetent. This study aimed to compare the presentation and outcome of CM in patients who are human immunodeficiency virus (HIV) negative with and without immunosuppression. We reviewed 255 clinical records from patients with CM who are HIV negative. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000221DOI Listing
January 2019
4 Reads

Antifungal activity study of the monoterpene thymol against Cryptococcus neoformans.

Nat Prod Res 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Departament of Pharmacy of Health Academic Unit , Federal University of Campina Grande , Cuité , Brazil.

Cryptococcus neoformans is a yeast fungus, which causes cryptococcosis, triggered by basidiospore inhalation and consequent dissemination to the central nervous system. In this study, we analyzed the antifungal action of thymol against 10 clinical strains of C. neoformans and analyzed the interaction of this monoterpene with sterols. Read More

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http://dx.doi.org/10.1080/14786419.2018.1547296DOI Listing
December 2018
1 Read

Rare presentation of cutaneous cryptococcosis in advanced HIV.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.

is an encapsulated yeast which causes opportunistic infection in the context of immunosuppression, including advanced HIV infection. Cryptococcal infection is systemic and can result in a fatal meningoencephalitis. Cutaneous lesions occur in 15% of those with systemic cryptococcosis and may be the first indicator of infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-227247DOI Listing
December 2018
2 Reads

Disseminated cryptococcal infection initially presenting as cryptococcal cellulitis in an HIV-negative patient on long-term steroids.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Infectious Diseases, Cork University Hospital/Mercy University Hospital, Cork, Ireland.

Cryptococcosis is an invasive fungal infection caused by encapsulated yeasts of the species. Inoculation usually occurs by inhalation through the respiratory tract, where it can then spread haematogenously to various sites, such as the central nervous system or the skin, in susceptible patients. We present the case of a 68-year-old male patient on long-term steroids who presented with a right upper limb cellulitis not responding to antibiotics. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22724
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http://dx.doi.org/10.1136/bcr-2018-227249DOI Listing
November 2018
8 Reads

Primary cutaneous cryptococcosis in an immunocompetent Iraq War veteran.

Cutis 2018 Nov;102(5):E30-E31

Department of Dermatology, Madigan Army Medical Center, Tacoma, Washington, USA.

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November 2018
1 Read

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2018 Dec 19. Epub 2018 Dec 19.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
December 2018
4 Reads

Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
4 Reads

The performance of serum cryptococcal capsular polysaccharide antigen test, histopathology and culture of the lung tissue for diagnosis of pulmonary cryptococcosis in patients without HIV infection.

Infect Drug Resist 2018 28;11:2483-2490. Epub 2018 Nov 28.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China,

Background: Clinicians may fail to make an early diagnosis of pulmonary cryptococcosis (PC) without HIV infection. Serum cryptococcal capsular polysaccharide antigen (CrAg) test, histopathology and culture of lung tissue play different roles in diagnosis of PC.

Objective: To investigate the performance of serum CrAg test, histopathology and culture of the lung tissue in diagnosis of PC without HIV infection. Read More

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http://dx.doi.org/10.2147/IDR.S178391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278883PMC
November 2018
2 Reads

Serum Cryptococcal Antigen Confirmed Pulmonary Cryptococcosis in an Immune-competent Adult Firstly Misdiagnosed of Tuberculosis from a Lung Biopsy: a Case Report and Literature Review.

Clin Lab 2018 Oct;64(11)

Background: Cryptococcal pneumonia is an uncommon lesion in immune-competent adults. Histological evidence of Cryptococcus neoformans is a gold criterion for diagnosis. Here we report a case firstly misdiagnosed as tuberculosis from a lung biopsy. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180616DOI Listing
October 2018
15 Reads

Comparative study of primary pulmonary cryptococcosis with multiple nodules or masses by CT and pathology.

Exp Ther Med 2018 Dec 17;16(6):4437-4444. Epub 2018 Sep 17.

Department of Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.

The manifestations of pulmonary cryptococcosis with multiple nodules or masses on computed tomography (CT) are diverse and difficult to differentiate from those of lung cancer and pulmonary tuberculosis. The present study compared the multislice spiral CT signs with pathological results and used the pathological results to explain the CT signs with the aim of improving the accuracy of the diagnosis of this disease. A retrospective analysis of 20 patients with primary pulmonary cryptococcosis with multiple nodules or masses was performed. Read More

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http://dx.doi.org/10.3892/etm.2018.6745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257807PMC
December 2018
1 Read

High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis.

BMC Infect Dis 2018 Dec 12;18(1):643. Epub 2018 Dec 12.

Department of Infectious Diseases, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai, China.

Background: The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alternative anticryptococcal choices. But evidence for its use in the treatment of HIV-uninfected cryptococcal meningitis (CM) remains sparse.

Methods: A retrospective analysis of HIV-uninfected CM patients who received fluconazole 800 mg/day for salvage therapy from January 2011 to December 2016 at Huashan Hospital, Shanghai, China was performed. Read More

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http://dx.doi.org/10.1186/s12879-018-3460-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291952PMC
December 2018

Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

J Vet Diagn Invest 2018 Dec 12:1040638718816358. Epub 2018 Dec 12.

Laboratories of Animal Pathology (Headley, Michelazzo, Oliveira), Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil.

We describe the pathologic, histochemical, and immunohistochemical findings associated with pulmonary and encephalitic cryptococcosis in a 3-y-old, mixed-breed, nanny goat from central-west Brazil. The goat had progressive neurologic signs over 30 d; cryptococcosis was diagnosed antemortem by cytologic evaluation of cerebrospinal fluid. Treatment was initiated, but the animal died spontaneously shortly thereafter. Read More

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http://dx.doi.org/10.1177/1040638718816358DOI Listing
December 2018

Detection and identification of fungi in bronchoalveolar lavage fluid from immunocompromised patients using panfungal PCR.

Folia Microbiol (Praha) 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.

Rapid diagnostics of fungal pneumonia and initiation of appropriate therapy are still challenging. In this study, we used two panfungal assays to test bronchoalveolar lavage fluid (BALF) samples to prove their ability to confirm invasive fungal disease diagnosis and identify causative agents. Two methods targeting different fungal rDNA regions were used, and the obtained PCR products were sequenced directly or after cloning. Read More

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http://dx.doi.org/10.1007/s12223-018-00669-wDOI Listing
December 2018
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[Cryptococcosis in Hospital Carlos Van Buren, Valparaiso: a clinical serie].

Rev Chilena Infectol 2018 Aug;35(4):420-423

Universidad de Valparaíso, Valparaíso, Chile.

Background: Cryptococcosis is a severe opportunistic mycotic infection, caused mainly by Cryptococcus neoformans. It can present as meningitis, pneumonia or cryptococcemia.

Aim: To characterize patients with Cryptococcus infection between January 1°, 2013 and June 30, 2016, in Hospital Carlos van Buren, Valparaíso, Chile. Read More

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http://dx.doi.org/10.4067/s0716-10182018000400420DOI Listing
August 2018
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Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro.

PLoS One 2018 7;13(12):e0208471. Epub 2018 Dec 7.

Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America.

Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized by various degree of chromosomal instability were isolated from clinical patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208471PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286144PMC
December 2018
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Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient.

Braz J Infect Dis 2018 Nov - Dec;22(6):499-502. Epub 2018 Dec 6.

Instituto de Infectologia Emilio Ribas, Departamento de Neurologia, São Paulo, SP, Brazil; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina (HCFM-USP), Departamento de Doenças e Infecciosas, São Paulo, SP, Brazil; Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Investigação Médica, São Paulo, SP, Brazil.

Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. Read More

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http://dx.doi.org/10.1016/j.bjid.2018.11.004DOI Listing
December 2018
3 Reads

Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study.

Lupus 2019 Jan 8;28(1):77-85. Epub 2018 Dec 8.

1 Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China.

Methods: A retrospective study was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

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http://dx.doi.org/10.1177/0961203318817118DOI Listing
January 2019
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[Opportunistic infections: What's new?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

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http://dx.doi.org/10.1055/a-0641-9456DOI Listing
December 2018
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Molecular types of Cryptococcus species isolated from patients with cryptococcal meningitis in a Brazilian tertiary care hospital.

Braz J Infect Dis 2018 Nov - Dec;22(6):495-498. Epub 2018 Nov 30.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Unidade de Doenças Infecciosas, Porto Alegre, RS, Brazil. Electronic address:

There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in HIV-infected patients with cryptococcal meningoencephalitis. Read More

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http://dx.doi.org/10.1016/j.bjid.2018.11.002DOI Listing
November 2018
2 Reads
1.096 Impact Factor

Myocardial cryptococcosis in an human immunodeficiency virus infected patient. Review of a fulminant clinical case.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; GREPAC, Instituto Hospital del Mar de Investigación Médica (IMIM), España; Universitat Autònoma de Barcelona, Barcelona, España.

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http://dx.doi.org/10.1016/j.medcli.2018.10.016DOI Listing
November 2018
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EQUAL Score 2018: A uropean Confederation of Medical Mycology Score Derived From Current Guidelines to Measure ity of Clinical Cryptococcosis Management.

Open Forum Infect Dis 2018 Nov 12;5(11):ofy299. Epub 2018 Nov 12.

Department I of Internal Medicine, University Hospital of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.

Cryptococcocis is an opportunistic fungal infection with high morbidity and mortality. Guidelines to aid clinicians regarding diagnosis, management, and treatment can be extensive and challenging to comply with. There is no tool to measure guideline adherence. Read More

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https://academic.oup.com/ofid/advance-article/doi/10.1093/of
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http://dx.doi.org/10.1093/ofid/ofy299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262117PMC
November 2018
2 Reads

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

MBio 2018 12 4;9(6). Epub 2018 Dec 4.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking. We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm. We also found that a mutant lacking the GRX domain displayed iron-related phenotypes similar to those of a Δ mutant, including poor growth upon iron deprivation. Read More

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http://dx.doi.org/10.1128/mBio.02377-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282196PMC
December 2018
2 Reads
6.786 Impact Factor