10,542 results match your criteria Cryptococcosis


Safety and tolerability of a novel oral formulation of amphotericin B: Phase I EnACT Trial.

Antimicrob Agents Chemother 2020 Aug 3. Epub 2020 Aug 3.

University of Minnesota, Minneapolis, MN, USA.

: Amphotericin B deoxycholate (AMB) has substantial toxicities. A novel encochleated amphotericin (cAMB) formulation has oral bioavailability, animal model efficacy, and minimal toxicity due to targeted drug delivery into macrophages where intracellular fungi reside. We conducted a phase I, ascending dose trial of cAMB administered at 1. Read More

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http://dx.doi.org/10.1128/AAC.00838-20DOI Listing

Disseminated cryptococcosis in a patient with adrenocortical carcinoma and Cushing's syndrome.

J Infect Chemother 2020 Jul 31. Epub 2020 Jul 31.

Department of Internal Medicine, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. Electronic address:

Corticosteroids have been used for the treatment of a great variety of diseases. Therefore, the relationship between high doses of cortisol and infections has been widely known and prophylactic therapy has been established. Adrenocortical carcinoma is a rare malignancy with poor prognosis, so little is known about how to deal with the complications resulting from hormone excess such as Cushing's syndrome. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.07.008DOI Listing

Disseminated cryptococcosis resembling miliary tuberculosis in a patient with acute myeloid leukemia.

J Infect Chemother 2020 Jul 31. Epub 2020 Jul 31.

Department of Medical Oncology and Hematology, Kobe University Hospital, Japan.

Disseminated cryptococcosis, usually involving the lungs and central nervous system, carries a high risk of morbidity and mortality in immunocompromised hosts. In this report, we describe a case of miliary pulmonary cryptococcosis in a patient with acute myeloid leukemia, initially resembling miliary tuberculosis. The diagnosis of disseminated cryptococcosis was made based on transbronchial lung biopsy with subsequent detection of Cryptococcus neoformans in blood and cerebrospinal fluid. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.07.004DOI Listing

Primary Cutaneous Cryptococcosis in an Older Immunocompetent Patient: A Case Report.

Ann Geriatr Med Res 2020 Jun 5;24(2):148-151. Epub 2020 Jun 5.

Department of Dermatology, Chosun University College of Medicine, Gwangju, Korea.

is an encapsulated yeast that can be found in pigeon droppings, hay, and dust. Primary cutaneous cryptococcosis (PCC) without systemic involvement is recognized as a distinct clinical condition and is rarely reported in immunocompetent patients. A 78-year-old woman with no history of other diseases except for hypertension presented with a painful diffuse erythematous plaque along with oozing on left forearm that had lasted for 7 weeks. Read More

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http://dx.doi.org/10.4235/agmr.20.0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370794PMC

Cryptococcal Infection in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation.

Mycoses 2020 Aug 1. Epub 2020 Aug 1.

Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

This review summarizes both the recent and relevant studies about cryptococcal infections in hematologic malignancies and hematopoietic stem cell transplantation. Although uncommon in this patient population, this infection carries a high mortality, especially if left untreated. Given the limited data, we draw some conclusions with respect to management from the solid organ transplantation and HIV-infected literature. Read More

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http://dx.doi.org/10.1111/myc.13153DOI Listing

Participation of Zip3, a ZIP domain-containing protein, in stress response and virulence in Cryptococcus gattii.

Fungal Genet Biol 2020 Jul 29:103438. Epub 2020 Jul 29.

Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil; Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil. Electronic address:

Cryptococcus gattii is an etiologic agent of cryptococcosis, a potentially fatal disease that affects humans and animals. The successful infection of mammalian hosts by cryptococcal cells relies on their ability to infect and survive in macrophages. Such phagocytic cells present a hostile environment to intracellular pathogens via the production of reactive nitrogen and oxygen species, as well as low pH and reduced nutrient bioavailability. Read More

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http://dx.doi.org/10.1016/j.fgb.2020.103438DOI Listing

Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China.

Mycopathologia 2020 Jul 31. Epub 2020 Jul 31.

Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College & Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, China.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been sweeping across the globe. Based on a retrospective analysis of SARS and influenza data from China and worldwide, we surmise that the fungal co-infections associated with global COVID-19 might be missed or misdiagnosed. Although there are few publications, COVID-19 patients, especially severely ill or immunocompromised, have a higher probability of suffering from invasive mycoses. Read More

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http://dx.doi.org/10.1007/s11046-020-00462-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394275PMC

[In vitro susceptibility of Chilean Cryptococcus neoformans strains of clinical source].

Rev Chilena Infectol 2020 Apr;37(2):124-128

Departamento de preclínicas, Escuela de Medicina, Universidad de Valparaíso, Chile.

Background: Cryptococcus yeast infections primarily affect immunocompromised patients. There have been few susceptibility studies conducted for this genus in Chile.

Aims: To determine the in vitro susceptibility to commonly used antifungals and evaluate the concordance between susceptibility determined by microdilution in broth and commercially available strips. Read More

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http://dx.doi.org/10.4067/s0716-10182020000200124DOI Listing

A novel method for identifying and distinguishing Cryptococcus neoformans and Cryptococcus gattii by surface-enhanced Raman scattering using positively charged silver nanoparticles.

Sci Rep 2020 Jul 27;10(1):12480. Epub 2020 Jul 27.

Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, Beijing, 100850, People's Republic of China.

There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis, and treatment. Read More

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http://dx.doi.org/10.1038/s41598-020-68978-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385644PMC

Purinergic signaling in infectious diseases of the central nervous system.

Brain Behav Immun 2020 Jul 24. Epub 2020 Jul 24.

Laboratory of Immunophysiology, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

The incidence of infectious diseases affecting the central nervous system (CNS) has been increasing over the last several years. Among the reasons for the expansion of these diseases and the appearance of new neuropathogens are globalization, global warming, and the increased proximity between humans and wild animals due to human activities such as deforestation. Neurotropism affecting normal brain function is shared by organisms such as viruses, bacteria, fungi, and parasites. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378483PMC

The Diverse Roles of Monocytes in Cryptococcosis.

J Fungi (Basel) 2020 Jul 16;6(3). Epub 2020 Jul 16.

Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham B15 2TT, UK.

Monocytes are considered to play a central role in the pathogenesis of infection. Monocytes and monocyte-derived macrophages and dendritic cells are key components for the control of infection, but paradoxically they can also contribute to detrimental host responses and may even support fungal proliferation and dissemination. Simultaneously, the polysaccharide capsule can impair the functions of monocytes. Read More

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http://dx.doi.org/10.3390/jof6030111DOI Listing

Structural and Bioactivity Characterization of Filipin Derivatives from Engineered Strains Reveals Clues for Reduced Haemolytic Action.

Antibiotics (Basel) 2020 Jul 16;9(7). Epub 2020 Jul 16.

Department of Molecular Biology, Area of Microbiology, Faculty of Biology, Universidad de León, 24071 León, Spain.

The rise in the number of immunocompromised patients has led to an increased incidence of fungal infections, with high rates of morbidity and mortality. Furthermore, misuse of antifungals has boosted the number of resistant strains to these agents; thus, there is urgent need for new drugs against these infections. Here, the in vitro antifungal activity of filipin III metabolic intermediates has been characterized against a battery of opportunistic pathogenic fungi-, , , , , , , , and -using the Clinical and Laboratory Standards Institute broth microdilution method. Read More

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http://dx.doi.org/10.3390/antibiotics9070413DOI Listing

Cryptococcosis mimicking recurrent neoplasm at the staple line on follow-up computed tomography.

Ann Thorac Surg 2020 Jul 20. Epub 2020 Jul 20.

National Taiwan University Hospital Yunlin Branch, Taiwan; National Taiwan University College of Medicine, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.121DOI Listing

Comparative performance of the laboratory assays used by a diagnostic laboratory hub for opportunistic infections in people living with HIV.

AIDS 2020 Jul 17. Epub 2020 Jul 17.

Global Action Fund for Fungal Infections, Geneva, Switzerland.

Objectives: We evaluated the comparative performance of different assays used in a Diagnostic Laboratory Hub that linked 13 HIV health care facilities for the diagnosis of tuberculosis, histoplasmosis, and cryptococcosis, and describing its functions in Guatemala compared with other National Reference Laboratories.

Methods: The following diagnostic techniques were analyzed in 24 months (2017-2018) in a cohort of patients with HIV: smear microscopy, mycobacterial and fungal cultures, isolator blood culture, PCR assays, and antigen detection tests.

Results: A total of 4,245 patients were included, 716 (16. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002631DOI Listing

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity.

Eur J Pharm Sci 2020 Jul 18;153:105473. Epub 2020 Jul 18.

Biological Sciences Department, Universidade Federal de São Paulo, Rua São Nicolau 210, 09913-030 Diadema, SP, Brazil. Electronic address:

Fungal infections are on the rise, since the imunocompromised population is increasing due to AIDS/HIV, organ transplant and chemotherapy. Many environmental and pathogenic fungi are able to accomplish melanin biosynthesis as a virulence factor to promote host invasion. Melanized cells are more resistant to radiation, oxidative and osmotic stresses; also melanin confers an advantage in vivo, since melanized cells are more resistant to phagocytic engulfment and oxidative stress caused by the host defense cells and by some antifungal drugs, such as fluconazole (FCZ) and amphotericin B (AmB). Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105473DOI Listing

Increased cryptococcal meningitis mortality among HIV negative, non-transplant patients: a single US center cohort study.

Ther Adv Infect Dis 2020 Jan-Dec;7:2049936120940881. Epub 2020 Jul 8.

Department of Medicine, Division of Infectious Diseases, University of Colorado, Anschutz Medical Center, 12700 E. 19th Avenue. Mail Stop B168. Aurora, CO 80045, USA.

Cryptococcal meningitis (CM) is an opportunistic fungal infection associated with human immunodeficiency virus (HIV) and other forms of immunosuppression. We lack a clear understanding of CM associated mortality among HIV-negative, non-transplant patients in the United States (US). This article compares clinical features and outcomes across HIV status in patients with laboratory-confirmed CM. Read More

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http://dx.doi.org/10.1177/2049936120940881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346692PMC

Acute paraparesis in HIV-infected patient after initiation of highly active antiretroviral therapy.

J Neurovirol 2020 Jul 15. Epub 2020 Jul 15.

Department of General Medicine, Government Medical College Hospital, Level 4 D Block, Sector 32, Chandigarh, 160030, India.

Neurological syndromes occur in around 40-70% of HIV-infected people. Direct central nervous system involvement by the virus usually manifests as HIV encephalitis, HIV leucoencephalopathy, vacuolar leucoencephalopathy or vacuolar myelopathy. Indirect involvement is usually associated with neurotropic opportunistic infections which include tuberculosis, toxoplasmosis, cryptococcosis and viral encephalitis such as herpes simplex, varicella-zoster, cytomegalovirus and Human polyomavirus 2. Read More

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http://dx.doi.org/10.1007/s13365-020-00879-4DOI Listing

Disseminated cryptococcosis with cutaneous manifestation.

Transpl Infect Dis 2020 Jul 11:e13412. Epub 2020 Jul 11.

Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Cutaneous cryptococcosis is uncommon. It is usually a result of disseminated infection and can present with a wide variety of skin lesions. We report a case of disseminated cryptococcosis in a kidney transplant recipient who presented with nodular lesions in the forehead following a bout of acute cellular rejection. Read More

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http://dx.doi.org/10.1111/tid.13412DOI Listing

Disseminated Cryptococcosis in a Young Immunocompetent Male.

Indian J Hematol Blood Transfus 2020 Jul 3;36(3):600-601. Epub 2020 Mar 3.

Departments of Pathology and Medicine, Christian Medical College and Hospital, Ludhiana, 141 008 Punjab India.

Cryptococcosis is an opportunistic infection caused by encapsulated yeasts of genus Cryptococcus. It usually infects immunocompromised patients and has multisystemic involvement, the common sites being lungs, central nervous system, skin and bone marrow. Disseminated cryptococcosis has also been reported in immunocompetent individuals. Read More

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http://dx.doi.org/10.1007/s12288-020-01271-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326886PMC

Early Cardiopulmonary Cryptococcus neoformans Infection After Liver Transplant: A Case Report.

Transplant Proc 2020 Jul 5. Epub 2020 Jul 5.

Avera Medical Group Transplant & Liver Surgery, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota; Department of Surgery, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota.

Cryptococcal infection (CI) is an uncommon fungal disease that poses a particular fatal risk to liver transplant (LT) recipients because of the potential rapid development and dissemination of the disease. Depending on the pathophysiology, CI may manifest with a wide range of clinical presentations that may delay early diagnosis and timely treatment. Additionally, most anticryptococcal therapies may threaten LT recipients owing to the associated hepatotoxicity of these medications. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.06.006DOI Listing

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Arch Pharm (Weinheim) 2020 Jul 8:e2000133. Epub 2020 Jul 8.

Postgraduate Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Cryptococcosis, caused by Cryptococcus spp., is an invasive fungal infection of the central nervous system, associated with high mortality, affecting mainly immunocompromised patients. Due to the development of resistance to the current therapy, there is an urgent need for less toxic and more effective antifungal agents. Read More

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http://dx.doi.org/10.1002/ardp.202000133DOI Listing

Trends and outcomes of fungal infections in hospitalized patients of inflammatory bowel disease: a nationwide analysis.

Transl Gastroenterol Hepatol 2020 5;5:35. Epub 2020 Jul 5.

Department of Gastroenterology & Hepatology, University of Toledo Medical Center, Toledo, OH, USA.

Background: Immunosuppressive therapy is being increasingly used in the management of inflammatory bowel disease (IBD) which comprises of ulcerative colitis (UC) and Crohn's disease (CD). Patients on immunosuppressive therapy are at increased risk of developing opportunistic fungal infections. We conducted this analysis to describe the epidemiology of opportunistic fungal infections in this cohort. Read More

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http://dx.doi.org/10.21037/tgh.2019.10.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063509PMC

Disseminated cryptococcal disease during treatment with idelalisib and corticosteroids for follicular lymphoma.

BMJ Case Rep 2020 Jul 5;13(7). Epub 2020 Jul 5.

Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

A patient on a regimen of idelalisib and corticosteroids for a relapse of follicular lymphoma presented to our emergency ward with a fever of unknown origin. Despite the initiation of broad-spectrum antibiotics and fluids, the patient's clinical condition deteriorated. Eventually, a diagnosis of disseminated cryptococcosis was established and immunophenotyping revealed complete absence of circulating B and CD4-T lymphocytes, and a markedly diminished CD8-T lymphocyte count. Read More

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http://dx.doi.org/10.1136/bcr-2020-235216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337623PMC

Evaluation of antifungal activity of cinnamaldehyde against Cryptococcus neoformans var. grubii.

Folia Microbiol (Praha) 2020 Jul 2. Epub 2020 Jul 2.

Department of Zoology, MMV, Banaras Hindu University, Varanasi, 221005, India.

Cryptococcosis is a potentially fatal fungal disease which has aggrandized with the emergence of AIDS and antifungal resistance. The currently used antifungals lack the broad-spectrum activity and result in several toxicities during long treatment regimens. Thus, the present study aims to evaluate the antifungal activity of cinnamaldehyde against Cryptococcus neoformans var. Read More

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http://dx.doi.org/10.1007/s12223-020-00806-4DOI Listing

Evaluation of low cryptococcal antigen titer as determined by the lateral flow assay in serum and cerebrospinal fluid among HIV-negative patients: a retrospective diagnostic accuracy study.

IMA Fungus 2020 10;11. Epub 2020 Mar 10.

Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Central Urumqi Road, Shanghai, 200040 China.

Cryptococcosis is one of the most common opportunistic infections in both immunocompetent and immunocompromised hosts. Although the cryptococcal antigen (CrAg) lateral flow assay (LFA) has been widely used in clinical settings due to its high sensitivity and specificity, the diagnostic value of a low CrAg LFA titers remains unclear. In this study, we performed a retrospective analysis of 149 HIV-negative patients with low CrAg LFA titers (≤1:10) in a Chinese tertiary hospital from January 2013 to December 2017, to evaluate the diagnostic value of low CrAg LFA titers in serum and cerebrospinal fluid (CSF) at different thresholds. Read More

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http://dx.doi.org/10.1186/s43008-020-00028-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325107PMC

[Pulmonary mycosis in patients with diabetes mellitus. Clinical characteristics and risk factors].

Rev Iberoam Micol 2020 Jun 29. Epub 2020 Jun 29.

Dirección de Investigación, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, México.

Background: Diabetes mellitus is a public health problem in Mexico, and the trend of the disease is increasing. From 2000 to 2017, 7.32 million new cases were diagnosed, with pulmonary mycoses being one of the most serious complications. Read More

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http://dx.doi.org/10.1016/j.riam.2020.04.002DOI Listing

Immunoglobulint G related disease complicated with pulmonary adenocarcinoma and cryptococcosis: a case report.

Scand J Rheumatol 2020 Jul 1:1-3. Epub 2020 Jul 1.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital , Beijing, China.

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http://dx.doi.org/10.1080/03009742.2020.1750689DOI Listing

Preclinical evaluation of acylhydrazone SB-AF-1002 as a novel broad-spectrum antifungal agent.

Antimicrob Agents Chemother 2020 Jun 29. Epub 2020 Jun 29.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

The incidence of invasive fungal infections is rising due to the increase in susceptible populations. Current clinically available drugs have therapeutic limitations due to toxicity, narrow spectrum of activity, and more importantly for the consistent rise of fungal species that are intrinsically resistant or develop resistance due to the prolonged therapy. Thus, there is an urgent need for new broad-spectrum antifungal agents with low toxicity and a novel mechanism of action. Read More

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http://dx.doi.org/10.1128/AAC.00946-20DOI Listing

Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak.

Cureus 2020 May 23;12(5):e8254. Epub 2020 May 23.

Infectious Disease, Luigi Sacco Hospital, University of Milan, Milan, ITA.

We report the case of a 61-year-old patient with a history of prostate cancer affected by bone metastasis. He presented to our attention for ulcerous and necrotic cutaneous lesions unresponsive to antibiotics. The spread of cutaneous lesions and the onset of neurological symptoms suggested a cryptococcal disease, which was confirmed by lumbar puncture and cutaneous biopsy. Read More

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http://dx.doi.org/10.7759/cureus.8254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309194PMC

An Elderly Patient with Pulmonary Cryptococcosis with Mediastinal Lymphadenopathy Who Was Successfully Treated with Amphotericin B and Flucytosine.

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Internal Medicine, Fukuyama City Hospital, Japan.

Pulmonary cryptococcosis develops not only in immunocompromised patients but also in immunocompetent patients. However, lymph node involvement is relatively rare in immunocompetent patients. We herein report the case of an 80-year-old man who was not in an apparent immunocompromised state but was diagnosed with pulmonary cryptococcosis with mediastinal lymphadenopathy. Read More

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http://dx.doi.org/10.2169/internalmedicine.4753-20DOI Listing

Fungal prostatitis due to endemic mycoses and Cryptococcus: A multicenter case series.

Prostate 2020 Sep 22;80(12):1006-1011. Epub 2020 Jun 22.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Background: Fungal prostatitis is exceedingly rare with mostly case reports.

Methods: Electronic medical records at three medical centers were searched for cases of fungal prostatitis due to endemic mycoses and Cryptococcus over the preceding 10 years.

Results: Seven cases were identified from 105 600 prostate biopsies within the Southern California Permanente Medical Group for an incidence of 0. Read More

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http://dx.doi.org/10.1002/pros.24034DOI Listing
September 2020

"False negative" CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature.

Med Mycol Case Rep 2020 Sep 11;29:29-31. Epub 2020 Jun 11.

Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.

There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with "false negative" CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques. Read More

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http://dx.doi.org/10.1016/j.mmcr.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296183PMC
September 2020

IL-25 Receptor Signaling Modulates Host Defense against Infection.

J Immunol 2020 Aug 19;205(3):674-685. Epub 2020 Jun 19.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani 12120, Thailand;

Cryptococcal meningitis is one of the most common life-threatening diseases caused by infection. Increasing evidence indicates that type 2 immunity is associated with disease progression by promoting fungal growth and dissemination. However, factors that govern this pathogenic response during infection are still elusive. Read More

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http://dx.doi.org/10.4049/jimmunol.2000073DOI Listing

Pathogen and host genetics underpinning cryptococcal disease.

Adv Genet 2020 18;105:1-66. Epub 2020 Mar 18.

Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, United Kingdom. Electronic address:

Cryptococcosis is a severe fungal disease causing 220,000 cases of cryptococcal meningitis yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two species complexes belonging to the genus Cryptococcus. All of these yeasts are environmentally ubiquitous fungi (often found in soil, leaves and decaying wood, tree hollows, and associated with bird feces especially pigeon guano). Read More

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http://dx.doi.org/10.1016/bs.adgen.2020.02.001DOI Listing

Cutaneous cryptococcosis simulating pyoderma gangrenosum.

Rev Soc Bras Med Trop 2020 12;53:e20200120. Epub 2020 Jun 12.

Hospital do Servidor Público Estadual de São Paulo, Programa de Residência Médica em Dermatologia, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0120-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294955PMC

Transmission of cryptococcosis by liver transplantation: A case report and review of literature.

World J Hepatol 2020 May;12(5):253-261

Department of Liver Transplantation, Instituto de Cardiologia do Distrito Federal, Brasilia 70673900, Brazil.

Background: Cryptococcosis is a fungal infection caused by the yeast-like encapsulated basidiomycetous fungus of the () species complex. These fungi are ubiquitous in soil and bird droppings, and infection by them is an important global health concern, particularly in immunosuppressed patients, such as organ transplant recipients and those infected by the human immunodeficiency virus. The fungus usually enters the body through the respiratory tract, but extremely rare cases of infection acquired by transplantation of solid organs have been reported. Read More

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http://dx.doi.org/10.4254/wjh.v12.i5.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280860PMC

HIV Infection Does Not Increase 10-Week Mortality of Chinese Cryptococcal Meningitis Patients.

AIDS Res Hum Retroviruses 2020 Jul 29. Epub 2020 Jul 29.

National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

The role of HIV infection in precipitating different clinical features in cryptococcal meningitis (CM) patients remains controversial. One hundred twelve CM patients living with HIV/AIDS (CM+HIV+ patients) and 112 CM patients living without HIV/AIDS (CM+HIV- patients) were enrolled after propensity score matching. Demographic characteristics, symptoms, routine blood tests, and biochemical and cerebrospinal fluid (CSF) profiles were compared between the two groups. Read More

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http://dx.doi.org/10.1089/AID.2020.0001DOI Listing

Clinical and Radiological Features of Patients With Pulmonary Cryptococcosis in a Hospital of North China.

Cureus 2020 May 11;12(5):e8061. Epub 2020 May 11.

Department of Respiratory Medicine, First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, CHN.

Objective:  The increasing incidence has led to more focus on pulmonary cryptococcosis in HIV-negative patients. We conducted a retrospective analysis of pulmonary cryptococcosis to understand the clinical characteristics, imaging features, diagnosis, treatment and prognosis of this disease in HIV-negative patients in respiratory department of a tertiary hospital in north China.

Method: We identified retrospectively those diagnosed with pulmonary cryptococcosis in the first medical center of Chinese People's Liberation Army General Hospital since 2009 to 2019. Read More

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http://dx.doi.org/10.7759/cureus.8061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286583PMC

Cryptococcal pericarditis in a heart transplant recipient.

Transpl Infect Dis 2020 Jun 13:e13366. Epub 2020 Jun 13.

Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA.

We present a case of Cryptococcus neoformans pericarditis in a cardiac transplant recipient. This article reviews the diagnosis, treatment, and complications of cryptococcosis specifically in transplant patients. While pericarditis is a rare manifestation of Cryptococcus infection, this case highlights that cryptococcosis should be considered in the differential diagnosis for solid organ transplant and immunocompromised patients presenting with pericardial effusions. Read More

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http://dx.doi.org/10.1111/tid.13366DOI Listing

The prevalence of cryptococcal antigen (CrAg) and benefits of pre-emptive antifungal treatment among HIV-infected persons with CD4+ T-cell counts < 200 cells/μL: evidence based on a meta-analysis.

BMC Infect Dis 2020 Jun 12;20(1):410. Epub 2020 Jun 12.

Division of infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Shapingba District, Chongqing, 400036, China.

Background: Current WHO guidelines (2018) recommend screening for cryptococcal antigen (CrAg) in HIV-infected persons with CD4+ T cell counts< 100 cells/μL, followed by pre-emptive antifungal therapy among CrAg positive (CrAg+) persons, to prevent cryptococcal meningitis related deaths. This strategy may also be considered for those persons with a CD4+ T cell count of < 200 cells/uL according the WHO guidelines. However, there is sparse evidence in the literature supporting CrAg screening and pre-emptive antifungal therapy in those HIV-infected persons with this CD4+ T cell counts< 200 cells/μL. Read More

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http://dx.doi.org/10.1186/s12879-020-05126-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291520PMC
June 2020
2.613 Impact Factor

Cryptococcal antigenemia and its predictors among HIV infected patients in resource limited settings: a systematic review.

BMC Infect Dis 2020 Jun 11;20(1):407. Epub 2020 Jun 11.

Department of Medical Microbiology, Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Cryptococcosis is an opportunistic fungal infection that primarily affects people with advanced HIV/AIDS and is an important cause of morbidity and mortality around the globe. By far the most common presentation of the disease is cryptococcal meningitis (CM), which leads to an estimated 15-20% of all HIV related deaths worldwide, 75% of which are in sub-Saharan Africa. However, to the best of our knowledge there is quite limited reviewed data on the epidemiology of cryptococcal antigenemia in a large HIV-infected population in resource limited settings. Read More

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http://dx.doi.org/10.1186/s12879-020-05129-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291525PMC

Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients.

J Int Med Res 2020 Jun;48(6):300060520927877

Department of Respiratory Medicine, Dongyang Hospital Affiliated to Wenzhou Medical University, Dongyang, Zhejiang Province, China.

Objective: To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.

Methods: This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Read More

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http://dx.doi.org/10.1177/0300060520927877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294504PMC

Clinical analysis in immunocompetent and immunocompromised patients with pulmonary cryptococcosis in western China.

Sci Rep 2020 Jun 10;10(1):9387. Epub 2020 Jun 10.

Center of Infectious Disease, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu, 610041, China.

Cryptococcosis is a systemic infection and it may occur in immunocompromised and immunocompetent hosts. In order to better understand the clinical characteristics of patients with PC in different immune status, we retrospectively investigated the clinical, radiological, and treatment profiles of immunocompetent and immunocompromised patients with PC during a 10-year period (2008-2017). As a result, out of 136 patients, 94 (69. Read More

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http://dx.doi.org/10.1038/s41598-020-66094-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287058PMC
June 2020
5.078 Impact Factor

Involvement of Mrs3/4 in mitochondrial iron transport and metabolism in .

J Microbiol Biotechnol 2020 May 21;30. Epub 2020 May 21.

Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea.

Mitochondria play a vital role in iron uptake and metabolism in pathogenic fungi, and also influence virulence and drug tolerance. However, the regulation of iron transport within the mitochondria of , a causative agent of fungal meningoencephalitis in immunocompromised individuals, remains largely uncharacterized. In this study, we identified and functionally characterized Mrs3/4, a homolog of the mitochondrial iron transporter, in var. Read More

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http://dx.doi.org/10.4014/jmb.2004.04041DOI Listing

Cryptococcal pneumonia in a human immunodeficiency virus-negative patient: A case report.

World J Clin Cases 2020 May;8(10):2038-2043

Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.

Background: Cases of cryptococcal pneumonia are frequently observed in patients with various innate or acquired immunodeficiencies, including organ transplant patients, cancer patients undergoing chemotherapy, patients with acquired immune deficiency syndrome, or patients on dialysis. Fluconazole is most often used to treat this condition when it is detected.

Case Summary: In the present report, we describe the case of a 42-year-old human immunodeficiency virus-negative man with normal immune function who had cryptococcal pneumonia that was diagnosed after undergoing computed tomography-guided percutaneous lung puncture. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.2038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262701PMC

Primary cutaneous cryptococcal infection due to fingolimod - Induced lymphopenia with literature review.

IDCases 2020 15;21:e00810. Epub 2020 May 15.

Infectious Disease Department, University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.

is an encapsulated heterobasidiomycetous fungus responsible for opportunistic infections worldwide in immunocompromised patients. Clinical presentation ranges from asymptomatic respiratory tract colonization to disseminated infection in any human body part. The central nervous system (CNS) and pulmonary diseases garner most of the clinical attention. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270602PMC

The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans.

mBio 2020 06 9;11(3). Epub 2020 Jun 9.

Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

The opportunistic fungal pathogen must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj1 (itochondrial espiration -domain protein ), necessary for virulence in The and J-domain-inactivated mutants had general growth defects at both routine laboratory and human body temperatures and were deficient in the major virulence factor of capsule elaboration. Read More

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http://dx.doi.org/10.1128/mBio.01127-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373193PMC

Epidemiology and risk factors for invasive fungal disease in liver transplant recipients in a tertiary transplant center.

Transpl Infect Dis 2020 Jun 8:e13361. Epub 2020 Jun 8.

Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background: Invasive fungal disease (IFD) in liver transplant recipients causes significant morbidity and mortality. We aim to describe institutional epidemiology and risk factors for IFD in the liver transplant population.

Methods: We conducted a retrospective cohort study of all adult liver transplant recipients in our institution from 2005 to October 2015 to describe the epidemiology of patients with proven and probable IFD according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Read More

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http://dx.doi.org/10.1111/tid.13361DOI Listing

Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report.

New Microbiol 2020 Jun;43(2):99-102

Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.

Cryptococcus species is still a very common opportunistic infection in AIDS patients. However, it is increasingly responsible for disease in otherwise immunocompromised individuals, such as transplant recipients and the heterogeneous group of patients with underlying immunologic diseases, hematologic disorders and organ failure syndromes. Clinical presentation, prognosis, and outcomes are difficult to define given these varied host groups, and tailoring treatments to fit the necessities of each patient is likewise challenging. Read More

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First case of minimal change nephrotic syndrome resolving with antifungal therapy for isolated pleural cryptococcal infection.

IDCases 2020 21;21:e00838. Epub 2020 May 21.

Division of Nephrology, University of Florida, College of Medicine, United States.

We report the case of a 71-year-old male with poorly controlled diabetes mellitus who presented with lower extremity edema and acute renal failure. He was diagnosed with nephrotic syndrome secondary to minimal change disease (MCD). Treatment with steroids was withheld due to concern for hyperglycemia in the context of his poorly controlled diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265054PMC