9,848 results match your criteria Cryptococcosis


Serum Cryptococcal Antigen Confirmed Pulmonary Cryptococcosis in an Immune-competent Adult Firstly Misdiagnosed of Tuberculosis from a Lung Biopsy: a Case Report and Literature Review.

Clin Lab 2018 Oct;64(11)

Background: Cryptococcal pneumonia is an uncommon lesion in immune-competent adults. Histological evidence of Cryptococcus neoformans is a gold criterion for diagnosis. Here we report a case firstly misdiagnosed as tuberculosis from a lung biopsy. Read More

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October 2018

Comparative study of primary pulmonary cryptococcosis with multiple nodules or masses by CT and pathology.

Exp Ther Med 2018 Dec 17;16(6):4437-4444. Epub 2018 Sep 17.

Department of Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.

The manifestations of pulmonary cryptococcosis with multiple nodules or masses on computed tomography (CT) are diverse and difficult to differentiate from those of lung cancer and pulmonary tuberculosis. The present study compared the multislice spiral CT signs with pathological results and used the pathological results to explain the CT signs with the aim of improving the accuracy of the diagnosis of this disease. A retrospective analysis of 20 patients with primary pulmonary cryptococcosis with multiple nodules or masses was performed. Read More

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December 2018

Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

J Vet Diagn Invest 2018 Dec 12:1040638718816358. Epub 2018 Dec 12.

Laboratories of Animal Pathology (Headley, Michelazzo, Oliveira), Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil.

We describe the pathologic, histochemical, and immunohistochemical findings associated with pulmonary and encephalitic cryptococcosis in a 3-y-old, mixed-breed, nanny goat from central-west Brazil. The goat had progressive neurologic signs over 30 d; cryptococcosis was diagnosed antemortem by cytologic evaluation of cerebrospinal fluid. Treatment was initiated, but the animal died spontaneously shortly thereafter. Read More

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December 2018

Detection and identification of fungi in bronchoalveolar lavage fluid from immunocompromised patients using panfungal PCR.

Folia Microbiol (Praha) 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.

Rapid diagnostics of fungal pneumonia and initiation of appropriate therapy are still challenging. In this study, we used two panfungal assays to test bronchoalveolar lavage fluid (BALF) samples to prove their ability to confirm invasive fungal disease diagnosis and identify causative agents. Two methods targeting different fungal rDNA regions were used, and the obtained PCR products were sequenced directly or after cloning. Read More

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December 2018

[Cryptococcosis in Hospital Carlos Van Buren, Valparaiso: a clinical serie].

Rev Chilena Infectol 2018 Aug;35(4):420-423

Universidad de Valparaíso, Valparaíso, Chile.

Background: Cryptococcosis is a severe opportunistic mycotic infection, caused mainly by Cryptococcus neoformans. It can present as meningitis, pneumonia or cryptococcemia.

Aim: To characterize patients with Cryptococcus infection between January 1°, 2013 and June 30, 2016, in Hospital Carlos van Buren, Valparaíso, Chile. Read More

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Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro.

PLoS One 2018 7;13(12):e0208471. Epub 2018 Dec 7.

Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America.

Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized by various degree of chromosomal instability were isolated from clinical patients. Read More

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December 2018

Invasive fungal disease in patients with systemic lupus erythematosus from Southern China: a retrospective study.

Lupus 2018 Dec 8:961203318817118. Epub 2018 Dec 8.

1 Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the characteristics and associated factors of invasive fungal disease in patients with systemic lupus erythematosus from Southern China.

Methods: A retrospective study was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. Read More

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December 2018

[Opportunistic infections: What's new?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

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December 2018
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Molecular types of Cryptococcus species isolated from patients with cryptococcal meningitis in a Brazilian tertiary care hospital.

Braz J Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Unidade de Doenças Infecciosas, Porto Alegre, RS, Brazil. Electronic address:

There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in predominantly HIV-infected patients with meningoencephalitis admitted to a tertiary care hospital in the southern area of Brazil. Read More

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November 2018
1 Read

Myocardial cryptococcosis in an human immunodeficiency virus infected patient. Review of a fulminant clinical case.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; GREPAC, Instituto Hospital del Mar de Investigación Médica (IMIM), España; Universitat Autònoma de Barcelona, Barcelona, España.

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November 2018

EQUAL Score 2018: A uropean Confederation of Medical Mycology Score Derived From Current Guidelines to Measure ity of Clinical Cryptococcosis Management.

Open Forum Infect Dis 2018 Nov 12;5(11):ofy299. Epub 2018 Nov 12.

Department I of Internal Medicine, University Hospital of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.

Cryptococcocis is an opportunistic fungal infection with high morbidity and mortality. Guidelines to aid clinicians regarding diagnosis, management, and treatment can be extensive and challenging to comply with. There is no tool to measure guideline adherence. Read More

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November 2018
1 Read

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

MBio 2018 Dec 4;9(6). Epub 2018 Dec 4.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking. We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm. We also found that a mutant lacking the GRX domain displayed iron-related phenotypes similar to those of a Δ mutant, including poor growth upon iron deprivation. Read More

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December 2018
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Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress.

MBio 2018 Dec 4;9(6). Epub 2018 Dec 4.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Heteroresistance to fluconazole (FLC) in is a transient adaptive resistance which is lost upon release from the drug pressure. It is known that clones heteroresistant to FLC invariably contain disomic chromosomes, but how disomy is formed remains unclear. Previous reports suggested that the aneuploid heteroresistant colonies in emerge from multinucleated cells, resembling the case in Although a small number of cells containing multiple nuclei appear in a short time after FLC treatment, we provide evidence that the heteroresistant colonies in the presence of FLC arise from uninucleate cells without involving multinuclear/multimeric stages. Read More

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December 2018

Disseminated cryptococcosis in Crohn's disease: a case report.

BMC Infect Dis 2018 Dec 4;18(1):620. Epub 2018 Dec 4.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn's disease with gastrointestinal cryptococcosis that resembled exacerbation of Crohn's disease. Read More

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December 2018
1 Read

Methamphetamine impairs IgG1-mediated phagocytosis and killing of by J774.16 macrophage- and NR-9640-microglia-like cells.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY

The prevalence of methamphetamine (METH) use is estimated at ∼35 million people worldwide, with over 10 million users in the United States. Chronic METH abuse and dependence expose the users to participate in risky behaviors that may result in the acquisition of HIV and AIDS-related infections. is an encapsulated fungus that causes cryptococcosis, an opportunistic infection that has recently been associated with drug users. Read More

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December 2018
1 Read

Case report: A fatal case of cryptococcosis in an immunocompetent patient due to (AFLP6/VGII).

JMM Case Rep 2018 Oct 23;5(10):e005168. Epub 2018 Oct 23.

Department Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

Introduction: Cryptococcosis in immunocompetent adults is a rare disease in Europe, mostly induced by members of the species complex. The diagnosis can be challenging due to its rarity, unspecific symptoms and long symptomless latency.

Case Presentation: A 49-year-old woman with a three weeks history of headache was admitted to the hospital due to discrete ataxia and impaired vision. Read More

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October 2018
1 Read

[Microbiological diagnosis of invasive mycosis].

Rev Iberoam Micol 2018 Nov 21. Epub 2018 Nov 21.

Servicio de Microbiología, Hospital Universitari i Politècnic La Fe, Valencia, España. Electronic address:

The prognosis of invasive fungal infections (IFI) depends on the speed of diagnosis and treatment. Conventional diagnostic methods are of low sensitivity, laborious and too slow, leading to the need for new, faster, and more efficient diagnostic strategies. There are several techniques for diagnosing a candidemia that are faster than the conventional blood culture (BC). Read More

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November 2018
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Increased susceptibility against Cryptococcus neoformans of lupus mouse models (pristane-induction and FcGRIIb deficiency) is associated with activated macrophage, regardless of genetic background.

J Microbiol 2018 Nov 19. Epub 2018 Nov 19.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The severity of cryptococcosis in lupus from varying geneticbackgrounds might be different due to the heterogeneity of lupus-pathogenesis. This study explored cryptococcosis in lupus mouse models of pristane-induction (normal geneticbackground) and FcGRIIb deficiency (genetic defect). Because the severity of lupus nephritis, as determined by proteinuria and serum creatinine, between pristane and FcGRIIb-/- mice were similar at 6-month-old, Cryptococcus neoformans was intravenously administered in 6-month-old mice and were age-matched with wild-type. Read More

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November 2018
1 Read

Disseminated cryptococcosis in a HIV-negative patient: Case report of a newly diagnosed hypertensive adult presenting with hemiparesis.

Med Mycol Case Rep 2018 Dec 12;22:4-7. Epub 2018 Jul 12.

Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

We report a case of disseminated cryptococcosis in a 42-year old immunocompetent female. Prior to admission at Bugando Medical Center, the patient was attended at three hospitals for hypertension and clinically diagnosed malaria. Following diagnosis of disseminated at our center, she was successfully treated with fluconazole but remained with visual loss. Read More

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December 2018

T11TS immunotherapy augments microglial and lymphocyte protective immune responses against Cryptococcus neoformans in the brain.

Scand J Immunol 2018 Nov 18:e12733. Epub 2018 Nov 18.

Department of Laboratory Medicine, School of Tropical Medicine, 108, C. R. Avenue, Kolkata, 700073, West Bengal, India.

Cryptococcus neoformans, the encapsulated yeast acquired through inhalation remains localized in lungs, but harbours the CNS in immunocompromised individuals. Several treatment regimes have failed combating this disease totally, but long term usage of drugs lead to organ damage. As T11-target structure (T11TS) has documented profound immune potentiation, we aimed to investigate the role of microglia, pivotal immune cells of brain in ameliorating cryptococcosis, with T11TS immunotherapy. Read More

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November 2018
2 Reads
1.882 Impact Factor

Disseminated Cryptococcosis in a Patient with Multiple Myeloma Treated with Daratumumab, Lenalidomide, and Dexamethasone.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Division of Hematology, Shonan Kamakura General Hospital, Japan.

We report a case of disseminated cryptococcosis in a patient with multiple myeloma (MM) during treatment with daratumumab, lenalidomide, and dexamethasone (DRd). A 62-year-old woman, who was diagnosed with IgGλ type MM, was treated with three cycles of bortezomib and dexamethasone and subsequently treated with three cycles of DRd before admission. She reached a stringent complete response and presented with lethargy and seizure. Read More

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November 2018
2 Reads

Disseminated cryptococcosis in two boys with novel mutation of CD40 Ligand-Associated X-linked hyper-IgM syndrome.

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

X-linked hyper-IgM syndrome (XHIM) caused by CD40L mutations is a primary immunodeficiency condition that increases susceptibility to opportunistic infections. Disseminated cryptococcosis in XHIM is rarely reported in children. Here, we report two related boys who have a novel hemizygous frameshift c. Read More

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October 2018
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Comparing the profile of respiratory fungal pathogens amongst immunocompetent and immunocompromised hosts, their susceptibility pattern and correlation of various opportunistic respiratory fungal infections and their progression in relation to the CD4+T-cell counts.

Indian J Med Microbiol 2018 Jul-Sep;36(3):408-415

Department of Microbiology, JNMC, AMU, Aligarh, Uttar Pradesh, India.

Introduction: Invasive fungal infections are increasingly common in the nosocomial setting.

Materials And Methods: The patients were divided into two groups immunocompetent and immunocompromised that is, patients with significant neutropenia <500 neutrophils/μl for longer than 10 days. microscopy, culture, identification of isolates were done and some specilised tests on serum and BAL for antigen detection were performed. Read More

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November 2018
4 Reads

Evaluation of Vitek MS™ for the differentiation of genotypes.

J Clin Microbiol 2018 Nov 14. Epub 2018 Nov 14.

Laboratorio de Micologia Medica (LIM 53), Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.

and are the main pathogenic species of invasive cryptococcosis among the species. Taxonomic studies have shown that these two taxa have different genotypes or molecular types with biological and eco-epidemiological peculiarities. MALDI-TOF mass spectrometry (MS) has been proposed as an alternative method for labor-intensive methods for and genotypes differentiation. Read More

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November 2018
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Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units.Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Mycoses 2018 Nov 13. Epub 2018 Nov 13.

Infectious Diseases Service, Department of Medicine, Lausanne University, Lausanne, Switzerland.

Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically-ill adult patients in intensive care units (ICU).

Objectives: To develop a standard set of definitions for IFD in critically-ill adult patients in ICU.

Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. Read More

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November 2018
3 Reads

PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis.

MBio 2018 Nov 13;9(6). Epub 2018 Nov 13.

Department of Microbiology, University of Georgia, Athens, Georgia, USA

Switching between different morphotypes is an adaptive cellular response in many microbes. In , the yeast-to-hypha transition confers resistance to microbial predation in the soil and is an integral part of its life cycle. Morphogenesis is also known to be associated with virulence, with the filamentous form being immune-stimulatory and protective in mammalian models of cryptococcosis. Read More

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November 2018
4 Reads

Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in Tanzania.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Ifakara Health Institute, Ifakara, Tanzania.

Background: Cryptococcal antigen (CrAg) screening in persons with advanced HIV/AIDS is recommended to prevent death. Implementing CrAg screening only in outpatients may underestimate the true CrAg prevalence and decrease its potential impact. Our previous 12-month survival/retention in CrAg-positive persons not treated with fluconazole was 0%. Read More

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November 2018
7 Reads

[Cryptococcal Meningitis in a Patient with Breast Cancer Receiving Everolimus: A Case of Successful Treatment with Continuous Cerebrospinal Fluid Drainage].

Brain Nerve 2018 Nov;70(11):1301-1305

Department of Neurosurgery, Kanagawa Cancer Center.

Cryptococcosis is a fungal infection that mainly occurs in immunocompromised patients. We present the first case of cryptococcal meningitis in a patient who was being administered everolimus for breast cancer. Everolimus, a selective inhibitor of mammalian target of rapamycin, is a molecular targeting agent that is administered not only as an immunosuppressive agent, but also as an anticancer therapeutic. Read More

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November 2018
1 Read

Epidemiological, Clinical and Outcome Aspects of Patients with Cryptococcosis Caused by Cryptococcus gattii from a Non-endemic Area of Brazil.

Mycopathologia 2018 Nov 10. Epub 2018 Nov 10.

Internal Medicine Department, Infectious Diseases Unit, Triângulo Mineiro Federal University, Medicina Tropical, Caixa Postal 118, Uberaba, Minas Gerais, CEP 38001-170, Brazil.

Cryptococcosis by Cryptococcus gattii occurs mainly in immunocompetent hosts, however, during the last decades, a growing number of cases in immunocompromised individuals have been noticed around the world. This report presents epidemiological, clinical and outcome aspects of patients with cryptococcosis caused by this species from a non-endemic area in Brazil. Of 278 Cryptococcus spp. Read More

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November 2018

The Buoyancy of Is Affected by Capsule Size.

mSphere 2018 Nov 7;3(6). Epub 2018 Nov 7.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

is an environmental pathogenic fungus with a worldwide geographical distribution that is responsible for hundreds of thousands of human cryptococcosis cases each year. During infection, the yeast undergoes a morphological transformation involving capsular enlargement that increases microbial volume. To understand the factors that play a role in environmental dispersal of and , we evaluated the cell density of using Percoll isopycnic gradients. Read More

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November 2018
1 Read

Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies.

Korean J Thorac Cardiovasc Surg 2018 Oct 5;51(5):350-355. Epub 2018 Oct 5.

Department of General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.

Background: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies.

Methods: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. Read More

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October 2018
5 Reads

Fungal vaccines, mechanism of actions and immunology: A comprehensive review.

Biomed Pharmacother 2019 Jan 3;109:333-344. Epub 2018 Nov 3.

Department of Medical Mycology and Parasitology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Fungal infections include a wide range of opportunistic and invasive diseases. Two of four major fatal diseases in patients with human immunodeficiency virus (HIV) infection are related to the fungal infections, cryptococcosis, and pneumocystosis. Disseminated candidiasis and different clinical forms of aspergillosis annually impose expensive medical costs to governments and hospitalized patients and ultimately lead to high mortality rates. Read More

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January 2019
8 Reads

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-infected individuals with CD4 <100 cells/µL: a stepped-wedge, cluster-randomized trial.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN, USA.

Background: HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for meningitis or death. We evaluated the effect of CrAg screening and pre-emptive fluconazole therapy, as an adjunct to antiretroviral therapy (ART), on six-month survival among persons with advanced HIV disease.

Methods: We enrolled HIV-infected, ART-naïve eligible participants with <100 CD4 cells/µL, in a stepped-wedge, cluster-randomized trial from July 2012 - December 2014 at 17 Ugandan clinics. Read More

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November 2018
5 Reads

Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature.

J Med Case Rep 2018 Nov 2;12(1):327. Epub 2018 Nov 2.

Shanghai Respiratory Research Institute, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: Pulmonary cryptococcosis is a common fungal infection frequently seen in immunocompromised patients. Owing to its nonspecific clinical and radiographic features, the differential diagnosis with secondary tuberculosis, malignant tumor, and bacterial pneumonia is sometimes difficult. Many case reports have focused on misdiagnosis of pulmonary cryptococcosis as a malignant tumor. Read More

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November 2018
6 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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October 2018
1 Read

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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October 2018
7 Reads

Transcriptional Heterogeneity of VGII Compared with Non-VGII Lineages Underpins Key Pathogenicity Pathways.

mSphere 2018 10 24;3(5). Epub 2018 Oct 24.

Infectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

is a pathogenic yeast of humans and other animals which causes disease predominantly in immunocompetent hosts. Infection begins when aerosolized yeast or spores enter the body, triggering an immune response, including engulfment by macrophages. To understand the early transcriptional signals in both the yeast and its mammalian host, we performed a time-course dual-transcriptome sequencing (RNA-seq) experiment for four lineages of (lineages VGI to IV) interacting with mouse macrophages at 1, 3, and 6 h postinfection. Read More

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October 2018
6 Reads

The Capsule of Cryptococcus neoformans Modulates Phagosomal pH through Its Acid-Base Properties.

mSphere 2018 10 24;3(5). Epub 2018 Oct 24.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

Phagosomal acidification is a critical cellular mechanism for the inhibition and killing of ingested microbes by phagocytic cells. The acidic environment activates microbicidal proteins and creates an unfavorable environment for the growth of many microbes. Consequently, numerous pathogenic microbes have developed strategies for countering phagosomal acidification through various mechanisms that include interference with phagosome maturation. Read More

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October 2018
1 Read

Phenotypic Variability Correlates with Clinical Outcome in Isolates Obtained from Botswanan HIV/AIDS Patients.

MBio 2018 Oct 23;9(5). Epub 2018 Oct 23.

School of Life and Environmental Sciences and the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, New South Wales, Australia

Pathogenic species of cause hundreds of thousands of deaths annually. Considerable phenotypic variation is exhibited during infection, including increased capsule size, capsule shedding, giant cells (≥15 μm), and micro cells (≤1 μm). We examined 70 clinical isolates of and from HIV/AIDS patients in Botswana to determine whether the capacity to produce morphological variants was associated with clinical parameters. Read More

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October 2018
8 Reads

Ophthalmic signs in Ugandan adults with HIV-associated cryptococcal meningitis: A nested analysis of the ASTRO-CM cohort.

Wellcome Open Res 2018 12;3:80. Epub 2018 Oct 12.

University of Minnesota, Minneapolis, MN, USA.

Cryptococcal meningitis is a leading cause of morbidity and mortality among HIV-infected persons, accounting for 15% of AIDS-related deaths. Visual disturbance is commonly reported, and a wide range of ophthalmic signs may be present on examination. There is limited published literature to date describing the range and incidence of ophthalmic signs in HIV-associated cryptococcal meningitis. Read More

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October 2018
3 Reads

Hybrids and hybridization in the Cryptococcus neoformans and Cryptococcus gattii species complexes.

Infect Genet Evol 2018 Dec 17;66:245-255. Epub 2018 Oct 17.

Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address:

The basidiomycetous yeasts of the Cryptococcus neoformans and Cryptococcus gattii species complexes (CNSC and CGSC respectively) are the causative agents of cryptococcosis, a set of life-threatening diseases affecting the central nervous system, lungs, skin, and other body sites of humans and other mammals. Both the CNSC and CGSC can be subdivided into varieties, serotypes, molecular types, and lineages based on structural variations, molecular characteristics and genetic sequences. Hybridization between the haploid lineages within and between the two species complexes is known to occur in natural and clinical settings, giving rise to intraspecific and interspecific diploid/aneuploid hybrid strains. Read More

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December 2018

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China.

Mycoses 2018 Oct 19. Epub 2018 Oct 19.

Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of paediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. Read More

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October 2018
2 Reads
1.800 Impact Factor

Unusual Presentation of Severe Endobronchial Obstruction Caused by Cryptococcus gattii in a Child: Case Report and Literature Review Severe Endobronchial Cryptococcosis in a Child.

J Pediatric Infect Dis Soc 2018 Oct 19. Epub 2018 Oct 19.

Department of Infectious Diseases and Microbiology, Children's Hospital Westmead, New South Wales, Australia.

Disease caused by Cryptococcus gattii typically manifests as meningoencephalitis or pulmonary nodules. Endobronchial lesions are rare, and most cases are caused by Cryptococcus neoformans. We describe here a case of endobronchial disease in a child caused by C gattii. Read More

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October 2018

Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context.

Med Mycol 2018 Oct 19. Epub 2018 Oct 19.

Oxford University Clinical Research Unit, Vietnam.

Cryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients with other forms of immunosuppression are also at risk, and disease is increasingly recognized in apparently immunocompetent individuals. Cryptococcus neoformans var. Read More

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October 2018
1 Read

[Clinical analysis of pulmonary cryptococcosis in non-human immunodeficiency virus infection patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Oct;50(5):855-860

Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.

Objective: To improve the understanding of the clinical features of pulmonary cryptococcosis in non-human immunodeficiency virus (non-HIV) infection patients and reduce delay in diagnosis, or misdiagnosis.

Methods: The clinical features, imaging characteristics, laboratory examinations, treatment and prognosis of 34 cases of pulmonary cryptococcosis were retrospectively analyzed. The data were collected from Peking University First Hospital from June 1997 to June 2016. Read More

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October 2018
6 Reads

Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK.

Pulmonary cryptococcosis is an important opportunistic invasive mycosis in immunocompromised patients, but it is also increasingly seen in immunocompetent patients. The main human pathogens are Cryptococcus neoformans and C. gattii, which have a worldwide distribution. Read More

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October 2018
2 Reads

Multi-locus sequence typing as a tool to investigate environmental sources of infection for cryptococcosis in captive birds.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Sydney School of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia.

A systematic investigation into environmental sources of infection was conducted at an Australian zoological park after cryptococcosis, caused by Cryptococcus gattii VGI, was diagnosed in a red-tailed black cockatoo (Calyptorhynchus banksii) residing in a large aviary with a diverse range of other avian species. A single tree with an extensive hollow was identified as the likely source of infection based on heavy culture of C. gattii VGI, multi-locus sequence typing and phylogenetic analysis of environmental and disease-related isolates. Read More

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October 2018
1 Read

Ischemic stroke as a complication of cryptococcal meningitis and immune reconstitution inflammatory syndrome: a case report.

BMC Infect Dis 2018 Oct 16;18(1):520. Epub 2018 Oct 16.

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, Chichiri, Blantyre, Malawi.

Background: Cryptococcal meningitis remains the leading cause of adult meningitis in Sub-Saharan Africa. Immune Reconstitution Inflammatory Syndrome (IRIS) following anti-retroviral therapy (ART) initiation is an important complication. Here we report the first documented case of a IRIS reaction presenting as an ischemic stroke. Read More

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October 2018
2 Reads

HIV-associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 counts.

J Infect Dis 2018 Oct 16. Epub 2018 Oct 16.

University of Minnesota, Minneapolis, MN, USA.

Background: Cryptococcal meningitis can occur in persons with less apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 counts.

Methods: We enrolled 736 participants from two prospective cohorts in Uganda and South Africa from November 2010 to May 2017. Read More

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October 2018
4 Reads
6.000 Impact Factor

Molecular epidemiology of environmental Cryptococcus species isolates based on amplified fragment length polymorphism.

J Mycol Med 2018 Dec 12;28(4):599-605. Epub 2018 Oct 12.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Objective: Cryptococcosis is a major opportunistic fungal infection caused by members of the genus Cryptococcus, mainly those belonging to the Cryptococcus neoformans/Cryptococcus gattii species complexes. Here, we report a comprehensive molecular epidemiological study of the environmental distribution of Cryptococcus isolates in Shiraz, Iran with review of litreature.

Method: A total of 406 samples were obtained from Eucalyptus trees and 139 samples from pigeon droppings. Read More

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December 2018