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Urol Oncol 2020 May 30. Epub 2020 May 30.

Department of Urology, NYU Langone Health, New York, NY.

Historically, the primary objection to partial gland ablation (PGA) for management of prostate cancer (CaP) has been disease multifocality and inability to localize significant disease. Improved disease localization and risk stratification with multiparametric magnetic resonance imaging and targeted biopsy, along with its minimal adverse impact on quality of life has enabled PGA to gain acceptance. Today, the primary barrier for adopting PGA is its unknown oncological outcomes. Read More

J Drugs Dermatol 2020 May;19(5):452-458

Background: The relationship between actinic keratoses (AKs) and nonmelanoma skin cancers (NMSCs) is well established. Patients with field cancerization are at high risk of developing new lesions. A treatment to interrupt new lesion formation or progression is required. Read More

BMJ Open 2020 Jun 1;10(6):e035610. Epub 2020 Jun 1.

Department of Physical Therapy, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil

Introduction: There is an unmet need to develop tailored therapeutic exercise protocols applying different treatment parameters and modalities for individuals with knee osteoarthritis (KOA). Cryotherapy is widely used in rehabilitation as an adjunct treatment due to its effects on pain and the inflammatory process. However, disagreement between KOA guidelines remains with respect to its recommendation status. Read More

Medicine (Baltimore) 2020 May;99(21):e20217

Rationale: Hemangiomas of the glans penis are very rare. Treatment options include surgical excision, laser therapy, intralesional sclerotherapy, electrofulguration, and cryotherapy. However, there have been no definitive treatment guidelines established to date. Read More

Photodiagnosis Photodyn Ther 2020 May 29:101847. Epub 2020 May 29.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China. Electronic address:

Patients with condylomata acuminata of the vulva usually have an increased difficulty for treatments and a higher risk of disease recurrence. Treatments for this disease varies, including surgical excision, cryotherapy, electrocautery, CO2 laser therapy, topical therapy, and photodynamic therapy (PDT), but none of these provides a satisfactory outcome in most refractory cases, especially for giant condyloma acuminatum (GCA). We reported two cases of GCA successfully cured with surgical removal, electrocautery and photodynamic therapy. Read More

Med J Armed Forces India 2020 Apr 15;76(2):156-160. Epub 2019 Apr 15.

Classified Specialist (Dermatology), Command Hospital (Eastern Command), Kolkata, India.

Background: Warts or verrucae are benign proliferations of the skin and mucosa resulting from infection with papilloma viruses. Warts form a small subset of patients attending skin out-patient department (OPD), out of which the plantar warts are one of the common presentation. The present study is an attempt to compare two modalities of treatment that is electrosurgery and cryotherapy in patients with plantar warts. Read More

J Eur Acad Dermatol Venereol 2020 Jun;34 Suppl 2:3-11

Laboratoires A-Derma, Pierre Fabre Dermo-Cosmétique, Lavaur, France.

Background: Inflammation from skin conditions such as psoriasis, eczema-like atopic dermatitis (AD) and hand eczema (HE) and following dermatological procedures (post-acts) can result in intense itching and cutaneous pain. Dermo-cosmetics containing plant extracts have been shown to reduce or alleviate these symptoms.

Objectives: Assessment of the tolerability and efficacy of a spray containing Rhealba\xAE Oat plantlets and Uncaria tomentosa extracts in adults and children with inflammatory skin diseases and after dermatological procedures. Read More

Eur J Appl Physiol 2020 May 30. Epub 2020 May 30.

Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France.

Purpose: A predominance of parasympathetic drive is observed following cold exposure. Such modulation of the autonomic nervous system (ANS) is associated with faster post-exercise recovery. Within this context, whole-body cryotherapy (WBC) has been spreading in sport medicine, though the optimal temperature and frequency are unclear. Read More

An Bras Dermatol 2020 May 11. Epub 2020 May 11.

Department of Tropical Dermatology, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Chromoblastomycosis is a subcutaneous mycosis with chronic evolution that mainly affects the lower limbs and, less frequently, the auricles. Clinically, it presents with papillary verrucous, nodular, and/or tumoral lesions, whether isolated or infiltrated, forming plaques and, sometimes, atrophic in some areas. Histopathologically, it is characterized by a dermal granulomatous inflammatory infiltrate, and the diagnosis can be confirmed by the presence of fumagoid bodies in anatomopathological or direct mycological exams. Read More

Prev Med 2020 May 27:106147. Epub 2020 May 27.

Division of Cancer Prevention and Control, Center for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:

India's cervical cancer screening was launched in 2016 and we evaluated baseline facility readiness using nationally representative data from the 2012-13 District Level Household and Facility Survey on 4 tiers of the public health care system - 18,367 sub-health centres (SHC's), 8540 primary health centres (PHC's), 4810 community health centres and 1540 district/sub-divisional hospitals. To evaluate facility readiness we used the Improving Data for Decision Making in Global Cervical Cancer Programmes toolkit on six domains - potential staffing, infrastructure, equipment and supplies, infection prevention, medicines and laboratory testing, and data management. Composite scores were created by summing responses within domains, standardizing scores across domains at each facility level, and averaging across districts/states. Read More

Med Sci Sports Exerc 2020 May 27. Epub 2020 May 27.

French National Institute of Sport (INSEP), Laboratory of Sport, Expertise and Performance (EA 7370), Paris, France.

Introduction: This study aimed to explore the relationship between elite rugby union match and post-match sleep architecture and to investigate the effects of a high-heat capacity mattress (MAT) and a whole-body cryotherapy session (WBC) on post-match sleep architecture.

Methods: Nineteen elite male U23 rugby union players performed in three official matches, followed by three experimental conditions, in a randomized order: MAT, WBC, and no intervention (CONT). Match load was evaluated using global positioning system (GPS) trackers and video analyses. Read More

Eur Urol 2020 May 24. Epub 2020 May 24.

Department of Urology, University College London Hospital. NHS Foundation Trust. London. UK.

Background: Salvage Robot-Assisted Radical Prostatectomy (sRARP) has been described as feasible treatment for the management of localised prostate cancer (PCa) recurrence after primary treatment. However, no large reports have published cancer and quality outcomes.

Objective: To report perioperative, functional and oncologic outcomes of sRARP in patients with localised PCa recurrence. Read More

Asian Pac J Cancer Prev 2020 May 1;21(5):1423-1429. Epub 2020 May 1.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito General Hospital, Yogyakarta, Indonesia.

Background: The Indonesian government has applied the cancer "see and treat" method which involves a visual inspection using acetic acid (VIA), followed by a cryotherapy procedure, to reduce the incidence of cervical cancer. However, compliance with the program is still low in the targeted population. This study aims to see what factors influence women to receive cryotherapy treatment if they have positive VIA result. Read More

Asian Pac J Cancer Prev 2020 May 1;21(5):1391-1398. Epub 2020 May 1.

International Agency for Research on Cancer, Lyon, France.

Background: The prospective randomized study aimed to compare the safety, acceptability and efficacy of thermal ablation (TA) to that of cryotherapy in screen and treat setting.

Methods: The participants were recruited prospectively in a community-based screening clinic in India. Women positive on visual inspection with acetic acid (VIA) test and/or Human Papillomavirus (HPV) test were assessed for eligibility for ablative treatment. Read More

Complement Ther Med 2020 May 19;50:102409. Epub 2020 Apr 19.

Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Imam Khomeini Street, Taleghani Hospital, Arak, Iran. Electronic address:

Background And Purpose: Restless legs syndrome (RLS) is a common sensory-motor disorder among the pregnant women. The aim of this study is to compare the impacts of two methods of immersion of legs in cold and warm water on the RLS symptoms among the pregnant women.

Methods: This randomized clinical trial was conducted on 80 pregnant women with RLS who referred to Taleghani educational-therapy center. Read More

Dermatol Ther 2020 May 22:e13640. Epub 2020 May 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Asyut, Egypt.

Recalcitrant alopecia areata is not uncommon in clinical practice and some patients experienced either treatment failure or recurrence with most of the conventional therapies. Several studies have evaluated the efficacy of cryotherapy in the treatment of alopecia areata with controversial results. This study aimed to optimize the ideal timing of liquid nitrogen cryospraying to achieve the most favorable results. Read More

Acta Neurol Taiwan 2020 Jun;29(2):64-66

University of California, San Diego, Department of Neurosciences, Stroke Center.

Background Purpose: Moyamoya syndrome is the progressive stenosis of intracranial carotids with secondary collateralization. Whole body cryotherapy (WBC) involves external cooling and is used in holistic and sports medicine, its neurologic effects are unknown.

Case Report: We report a first case of symptoms of moyamoya syndrome presenting following WBC and diagnosed with classic MRI ( "Brush Sign", "Ivy sign") and digital subtracted angiography. Read More

Acta Parasitol 2020 May 20. Epub 2020 May 20.

Genetic Engineering and Biotechnology Research Institute, University of Sadat city, Sadat, Egypt.

Objective: The aim of this study was to evaluate the epidemiology, clinical presentation and types of treatment of cutaneous leishmaniasis (CL) in the province of Ilam (Western Iran) in 5 years (from May 2013 to January 2018). This cross-sectional study involved patients diagnosed with CL who were referred to Mehran City Health center.

Methods: All patients were diagnosed by clinical and parasitological (Giemsa staining of lesion to observe the parasite) methods. Read More

Dermatol Ther 2020 May 19. Epub 2020 May 19.

Dermatology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background/objectives: Anogenital condylomata acuminata are induced by human papillomavirus (HPV) and they rarely manifest in immunocompetent children. Therapeutic options depend on patient's age and general conditions and extension of the lesions. However, management is still a challenge and recurrences are frequent. Read More

Am J Ophthalmol Case Rep 2020 Sep 20;19:100689. Epub 2020 Apr 20.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina Charleston, SC, USA.

Purpose: Report a case of corneal melt in a patient with conjunctival intraepithelial neoplasia (CIN) treated with topical interferon (IFN) alpha-2B.

Observations: An 89-year-old man presented with gelatinous paralimbal lesions of the left eye extending onto the cornea with corneal neovascularization extending 5-6 clock hours. Nasally there was mild absence of the terminal vascular loops of the limbal palisades of Vogt and conjunctivalization. Read More

Semin Intervent Radiol 2020 Jun 14;37(2):157-165. Epub 2020 May 14.

Department of Radiology, UAMS College of Medicine, Little Rock, Arkansas.

Advancements in medical imaging and device technology allow minimal invasive procedures for the diagnosis and treatment of various disorders. For the management of tumors in head and neck region, these image-guided interventions play essential role in the often used multidisciplinary approach. Tissue sampling under ultrasound or computed tomography guidance is generally the first step to reach a pathological diagnosis. Read More

J Dermatol 2020 May 15. Epub 2020 May 15.

Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.

Porokeratoma is a recently described solitary or multiple tumor-like acanthoma, sharing the histological feature of cornoid lamellae with porokeratosis. Whether porokeratoma is a variant of porokeratosis is controversial. We report a rare case of a 53-year-old Chinese woman who presented with multiple, symmetrical, hemispherical and verrucous plaques on her lower extremities that had been present for 20 years. Read More

LGBT Health 2020 May 14. Epub 2020 May 14.

Basic Health International, Pittsburgh, PA, USA; New York, NY, USA; and San Salvador, El Salvador.

Sexual and gender minority persons in low-income countries have very limited access to routine health services. This study evaluated the feasibility of using a self-sampled human papillomavirus (HPV) test to increase access to screening for cervical cancer among transgender men in El Salvador. We partnered with a local advocacy organization for recruitment. Read More

Dermatol Ther (Heidelb) 2020 May 14. Epub 2020 May 14.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Read More

Dermatol Ther 2020 May 12:e13559. Epub 2020 May 12.

Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. This single-blind, randomized clinical trial was performed on 60 subjects presenting with plantar wart in Sabzevar, Iran in 2018. Read More

Cureus 2020 May 6;12(5):e7983. Epub 2020 May 6.

Canadian Clincial Trials Group, Queen's University, Kingston, CAN.

Background Optimal management of isolated local recurrence of prostate cancer after primary radiotherapy remains to be defined. Up-front androgen deprivation therapy (ADT) is widely used but may adversely affect the quality of life and is essentially a palliative treatment. Local salvage carries a different side-effect profile and is potentially curative, but it has not been compared to ADT. Read More

J Endod 2020 May 5. Epub 2020 May 5.

Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.

Introduction: The aim of this review article was to discuss the concept of cryotherapy, its mechanism, physiological effect, and its different applications in the field of endodontics.

Methods: The selected articles were limited to those published in the English language using the following key words: cryotherapy, cryogenic treatment of nickel-titanium, cold therapy, and cryotherapy in endodontics. The screening of articles was based on an electronic search of the following databases: PubMed, Scopus, Web of Science, and Egyptian Knowledge Bank. Read More

Equine Vet J 2020 May 9. Epub 2020 May 9.

Gail Homes Equine Orthopedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Background: Rehabilitation of tendon injuries in horses often involves cryotherapy to reduce inflammation and occasionally tissue heating to increase collagen extensibility. The application of alternating cold and hot (ie contrast therapy) is widely used in human physical therapy; however, its utility in equine rehabilitation is largely unknown.

Objectives: The objectives of this study were to (a) assess if the equipment could achieve therapeutic tissue temperatures (<15 and >40°C) at different tissue depths relative to the digital flexor tendons and (b) evaluate the time-temperature profiles during serial heating and cooling cycles using a contrast therapy device. Read More

Vision (Basel) 2020 May 6;4(2). Epub 2020 May 6.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton BN2 5BF, UK.

Purpose: To present a case of delayed onset scleromalacia and conjunctival bleb formation one year after conjunctival melanoma excision with intraoperative use of mitomycin-C (MMC) and double-freeze-thaw technique.

Methods: Case report.

Results: A 69-year-old woman had a conjunctival melanoma excised by the 'no touch technique' with intraoperative application of 0. Read More

Eye (Lond) 2020 May 6. Epub 2020 May 6.

Şanlıurfa Balıklıgöl State Hospital, Şanlıurfa, Turkey.

Objectives: To evaluate the long-term treatment outcomes in intraocular retinoblastoma (RB) including the associated factors for eventual treatment with external beam radiotherapy (EBRT) and enucleation as well as to analyse the risk factors for metastasis and death in extraocular RB.

Methods: Retrospective analysis of 390 eyes from 256 (89.8%) intraocular RB and 29 (10. Read More

Am J Ophthalmol Case Rep 2020 Jun 13;18:100708. Epub 2020 Apr 13.

Department of Ophthalmology, Duke University, Durham, NC, USA.

Purpose: To describe the management of a rhegmatogenous retinal detachment (RRD) in a pregnant patient.

Observations: A 30-year-old, 26-week pregnant female presented with curtain vision loss in the left eye. Exam findings were significant in the left eye for an inferior fovea-sparing RRD. Read More

Am J Sports Med 2020 May 4:363546520914911. Epub 2020 May 4.

Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan.

Background: Pitch velocity is associated with elbow injuries among skillful baseball players. However, the relationship between pitch velocity and throwing elbow injuries among youth players has not yet been clarified.

Purpose: To investigate the influence of pitch velocity on medial elbow pain and medial epicondyle abnormality among youth baseball players. Read More

Womens Health (Lond) 2020 Jan-Dec;16:1745506520914804

Global Health Academy and Usher Institute, The University of Edinburgh, Edinburgh, UK.

Cervical cancer is the fourth most common cancer among women globally, with approximately 580,000 new diagnoses in 2018. Approximately, 90% of deaths from this disease occur in low- and middle-income countries, especially in areas of high HIV prevalence, and largely due to limited prevention and screening opportunities and scarce treatment options. In this overview, we describe the opportunities and challenges faced in many low- and middle-income countries in delivery of cervical cancer detection, treatment and complete pathways of care. Read More

J Cancer Res Ther 2020 Jan-Mar;16(1):170-172

Department of Dermatology, Netherlands Cancer Institute, Amsterdam, Netherlands.

With the discovery of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, new treatment possibilities arose against metastatic melanoma. A frequent adverse effect of BRAF inhibitor therapy is the induction of epithelial proliferations such as cutaneous squamous cell carcinoma and verrucous papilloma. Here, we describe a case in which a patient developed extensive anal epithelial proliferations resembling condylomata acuminata, after starting vemurafenib treatment. Read More

J Oral Maxillofac Surg 2020 Apr 6. Epub 2020 Apr 6.

Professor Doctor and Department Head, Department of Otorhinolaryngology, Okmeydani Training and Research Hospital, Istanbul, Turkey.

Purpose: Edema and ecchymosis are among the most important morbidities after rhinoplasty. The aim of the present study was to investigate the effects of hilotherapy application compared with traditional ice applications after rhinoplasty in terms of periorbital edema, ecchymosis, and pain.

Patients And Methods: A total of 60 patients (35 women and 25 men) had undergone primary rhinoplasty with the same surgeon. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(2):20-28

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim of this study - the comparative effectiveness of cryotherapy (CT) with ice 0 °C, CT with ice 0 °C + SMC (cryo-SMC), air cryotherapy (ACT) -30 °C, hyperbaric gas cryotherapy (HC) CO2 -78 °C.

Material And Methods: We examined 150 patients with II - IV stage osteoarthritis of the knee and hip joints, movement pain of more than 40 mm on a VAS and Leken index more than 9. 120 of these patients received a course of CT of various temperatures and cryo-SMC for 2 weeks: 1st group (=30) - CT of ice 0 °C; 2nd group (=30) - cryo-SMC; 3rd group (=30) - ACT; 4th group (=30) - HC. Read More

Int J Gynaecol Obstet 2020 Apr 29. Epub 2020 Apr 29.

Duke University, Durham, NC, USA.

Objective: To evaluate access to treatment after community-based HPV testing as testing within screen-and-treat programs has the potential to lower mortality from cervical cancer in low-resource settings.

Methods: A prospective cohort study was conducted in western Kenya in 2018. Women aged 25-65 years underwent HPV self-testing. Read More

BMC Ophthalmol 2020 Apr 28;20(1):168. Epub 2020 Apr 28.

Department of ophthalmology, the first hospital affiliated to Army Medical University (Southwest Hospital), Chongqing, 400038, China.

Background: To report a case of a young patient with neurofibromatosis type 1 (NF1).

Methods: Here we review the treatment administered to a 7-year-old NF1 patient with neovascular glaucoma as the primary diagnosis.

Case Presentation: A 7-year-old boy developed visual loss in the right eye associated with periocular pain and ipsilateral headache that had persisted for 1 week. Read More

Eur J Surg Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Surgery, Institut Curie, PSL University, 26 rue d'Ulm, Paris, France. Electronic address:

The treatment of desmoid tumours (DTs) has greatly evolved in recent years, and surgery is no longer considered a first-line treatment. Percutaneous biopsy with molecular analysis for beta-catenin or APC gene mutation provides a certain diagnosis. After imaging, a specialized multidisciplinary tumour board (MDT) addresses the following therapeutic strategy. Read More

J Thorac Cardiovasc Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: To evaluate the feasibility of new retrievable covered metallic segmented Y airway stents modified with 3-dimensional (3D) printing for gastrorespiratory fistula involving carina or main bronchi.

Methods: We designed a new retrievable covered metallic segmented Y airway stent to fit the anatomical characteristics of the carina region in individual patients. All stents were individually customized based on a 3D-printed mold. Read More

J Emerg Nurs 2020 Apr 24. Epub 2020 Apr 24.

Introduction: This study aimed to determine the effect of cold application time on symptoms, edema, and patient satisfaction in soft tissue injuries.

Methods: A randomized controlled trial was conducted with 105 patients who were treated with cold applications of different durations (10, 20, and 30 minutes). Interview-assisted data were collected on symptoms and patient satisfaction. Read More

BMJ Glob Health 2020 29;5(3):e001886. Epub 2020 Mar 29.

Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

Introduction: We aimed to quantify health outcomes and programmatic implications of scaling up cervical cancer (CC) screening and treatment options for women living with HIV in care aged 18-65 in Kenya.

Methods: Mathematical model comparing from 2020 to 2040: (1) visual inspection with acetic acid (VIA) and cryotherapy (Cryo); (2) VIA and Cryo or loop excision electrical procedure (LEEP), as indicated; (3) human papillomavirus (HPV)-DNA testing and Cryo or LEEP; and (4) enhanced screening technologies (either same-day HPV-DNA testing or digitally enhanced VIA) and Cryo or LEEP. Outcomes measured were annual number of CC cases, deaths, screening and treatment interventions, and engaged in care (numbers screened, treated and cured) and five yearly age-standardised incidence. Read More

J Sport Rehabil 2020 Apr 23:1-5. Epub 2020 Apr 23.

Context: Athletes in combat sports who have sustained facial hematomas during competition have traditionally been treated with an enswell. These treatments take place between rounds of the competition and generally last less than 60 seconds. The efficacy of this modality has not been studied. Read More

Physiotherapy 2020 Mar 3. Epub 2020 Mar 3.

Federal University of Santa Catarina - Aging, Resources and Rheumatology Laboratory (LERER/UFSC), Araranguá, Santa Catarina, Brazil. Electronic address:

Medicine (Baltimore) 2020 Apr;99(16):e19623

Departments of Surgery (Ophthalmology) King Hussein Cancer Center.

To report on the characteristics and outcome of management of Coats' disease, and to describe a novel surgical technique for management of stage 3B with total retinal detachment (RD) by scleral external drainage with anterior chamber (AC-maintainer) placement before the drainage without pars plana vitrectomy.A retrospective study of 26 eyes from 25 Coats' patients. Outcome measures included: demographics, presentation, laterality, stage, treatment, and outcome. Read More

ACG Case Rep J 2020 Jan 20;7(1):e00309. Epub 2020 Jan 20.

University of Virginia, Charlottesville, VA.

The use of endoscopic spray cryotherapy to manage pathological conditions of the esophagus has become increasingly common. This mucosal ablation technique is believed to carry a lower risk of bleeding than other modalities. A 71-year-old woman and a 64-year-old man with portal hypertension and varices were diagnosed with invasive esophageal adenocarcinoma during routine variceal surveillance. Read More

J Clin Aesthet Dermatol 2020 Feb 1;13(2):33-43. Epub 2020 Feb 1.

Dr. Betarbet is with the Emory University School of Medicine in Atlanta, Georgia and the Division of Plastic Surgery at The University of Texas Medical Branch in Galveston, Texas.

Keloids are abnormal scars that cause significant emotional and physical distress in patients when inadequately treated. Keloid formation is theorized to occur as a result of an imbalance between an increased synthesis of collagen and extracellular matrix and decreased degradation of these products. Inflammatory mediators- namely, transforming growth factor beta-have been proposed to influence the dysregulation of collagen remodeling in the scar healing process. Read More

Contemp Clin Dent 2019 Apr-Jun;10(2):214-219

Department of Orthodontics, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Aims: The main aim of this study was to evaluate the melanocyte response following depigmentation by cryosurgery and mucosal excision at both clinical and histopathological levels during 6 months.

Subjects And Methods: A total of 15 individuals, aged 25-45 years with hyperpigmentation on the facial aspect of the gingiva present in the esthetic zone were included. A split-mouth approach was used, wherein one side received depigmentation by a scalpel and the other side received cryotherapy, with the choice of the therapy and side chosen by the spin of the coin. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):272-278

Department of Ophthalmology, Peking University People's Hospital, Eye diseases and optometry institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

To evaluate the treatment of vasoproliferative tumors of the retina (VPTR). Retrospective case series study. The clinical data of 20 VPTR patients (20 eyes) were retrospectively analyzed, including 2 eyes only treated by cryotherapy, 1 eye only treated by photocoagulation and 1 eye only treated by ruthenium-106 brachytherapy. Read More

Cryobiology 2020 Apr 16. Epub 2020 Apr 16.

Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Municipal Key Clinical Specialty of Gynecologic Oncology, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. Electronic address:

Young patients with early endometrial cancer have a strong desire to retain reproductive function, which require us to develop a therapeutic method that can not only assure the complete resection of tumor but also retain the uterine integrity. In the present study, we proposed a fertility-sparing surgery option that combined hysteroscopic resection with cryoablation to achieve this goal. To verify the safety and effectiveness of cryoablation for local uterine wall, we designed the experiment in pig model using a novel cryoablation balloon probe. Read More