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    Irreversible Electroporation for Prostate Cancer as Salvage Treatment Following Prior Radiation and Cryotherapy.
    Rev Urol 2017 ;19(4):268-272
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterNew York, NY.
    Salvage treatment options after localized primary treatment failure of prostate cancer are limited and associated with risk for serious complications. We report on the management details of a 57-year-old African American man treated with partial-gland ablation using irreversible electroporation following local recurrence after brachytherapy and prior salvage cryoablation. Therapeutic and functional outcomes were assessed by conventional means, including serum prostate-specific antigen values and prostate biopsy results. Read More

    Cooling of the oral mucosa to prevent adverse effects of chemotherapeutic agents - an in vitro study.
    J Oral Pathol Med 2018 Feb 22. Epub 2018 Feb 22.
    School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
    Background: The cytotoxic effect of chemotherapeutic agents to the oral mucosa, as a side-effect of cancer treatment, is a major problem. Cooling the oral mucosa using ice chips in conjunction with chemotherapy is known to reduce the severity of oral mucositis. However, although the use of ice chips is of clinical value, this method of cooling has inherent problems including discomfort for the patient, non-uniformity and fluctuations in cooling temperature throughout the oral cavity. Read More

    Update on the management of vasoproliferative tumour.
    Arch Soc Esp Oftalmol 2018 Feb 16. Epub 2018 Feb 16.
    Servicio de Oftalmología, Hospital Universitario Virgen de las Nieves, Complejo Hospitalario Universitario, Granada, España.
    Case Report: Here we report a 19-year-old female patient who presented a vasoproliferative tumour. It caused complications, such as epiretinal membrane, macular oedema, vitreous haemorrhage, and exudative retinal detachment. The patient was treated with 3 injections of intravitreal bevacizumab, an intravitreal dexamethasone implant, tocilizumab, and double freeze-thaw cryotherapy. Read More

    Effect of whole body cryotherapy interventions on health-related quality of life in fibromyalgia patients: A randomized controlled trial.
    Complement Ther Med 2018 Feb 6;36:6-8. Epub 2017 Nov 6.
    Physical Medicine and Rehabilitation Department, Sébastopol Hospital, University of Reims Champagne-Ardenne, France.
    Introduction: Although fibromyalgia syndrome (SFM) affects 2-4 percent of adults, research has not identified a preferred therapeutic option for patients worldwide yet. Based on recent findings, it can be expected that whole body cryotherapy can improve health-reported quality of life by alleviating the symptoms of musculoskeletal pain and fatigue.

    Objective: Our aim was to determine whether whole body cryotherapy only can result in improved perceived health and quality of life in fibromyalgia patients. Read More

    Osteoblastomatosis: an unusual diagnosis and treatment.
    Skeletal Radiol 2018 Feb 15. Epub 2018 Feb 15.
    Complejo Hospitalario Univeritario de Ferrol, A Coruña, Spain.
    Osteoblastomatosis (OBLT), also referred to as multifocal osteoblastoma (OB), is an unusual and recently described entity consisting of multifocal tumors histologically consistent with osteoblastoma and osteoid osteoma (OO) but radiologically mimicking a vascular bone lesion. OBLT treatment is based on aggressive procedures, such as amputation, en bloc resection, and chemotherapy. Only one previously reported case was successfully treated following a multimodal approach consisting of curettage, cryotherapy, intravenous bisphosphonates, and radiofrequency ablation. Read More

    Endobronchial Ablative Therapies.
    Clin Chest Med 2018 Mar;39(1):139-148
    Health Sciences University, Izmir Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery, 35110, Izmir, Turkey. Electronic address:
    Endobronchial ablative therapies, such as mechanical debulking, laser therapy, electrocautery, argon plasma coagulation, cryotherapy, brachytherapy, photodynamic therapy, microdebrider bronchoscopy, resector balloon deobstruction, and intratumoral chemotherapy, are performed through a rigid or flexible bronchoscope in palliating or curing symptomatic malignant and benign airway lesions to improve symptoms, quality of life, and survival. Technical factors together with patient- and lesion-specific features determine the therapy of choice, as each therapy is different in capacity, limitation, and complications. In this article, indications, contraindications, and complications of endobronchial ablative therapies as well as practical issues related to their rational and cost-effective use are reviewed. Read More

    Pigmentation Disorders: Diagnosis and Management.
    Am Fam Physician 2017 Dec;96(12):797-804
    Norton Audobon Hospital, Louisville, KY, USA.
    Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

    Management of cervical premalignant lesions.
    Curr Probl Cancer 2018 Jan 11. Epub 2018 Jan 11.
    Jehangir Clinical Development Centre, Jehangir Hospital Premises and Prayas, Pune, India.
    Treatment of cervical premalignant lesions (cervical intraepithelial neoplasia; CIN) of different grades is very effective, simple, and safe. The entire transformation zone of the cervix needs to be treated either by an ablative technique (cryotherapy or thermal ablation) or an excisional technique (large loop excision of transformation zone or cold knife conization); the choice of treatment depends on the size and location of the lesion and the type of the transformation zone. The cure rate after ablative treatment of high-grade CIN may be little lower than that after excisional treatment. Read More

    Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: Randomised controlled trials.
    J Plast Reconstr Aesthet Surg 2018 Feb 6. Epub 2018 Feb 6.
    Department of Plastic and Reconstructive Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
    Background: Keloids are a burden for patients due to physical, aesthetic and social consequences. Treatment remains a challenge due to therapy resistance and high recurrence rates. The main goals of treatment are to improve scar appearance and symptoms and patients' quality of life (QoL). Read More

    Bridging multimodal pain management provides 48-hour pain control in patients undergoing total shoulder replacement.
    J Shoulder Elbow Surg 2018 Feb 7. Epub 2018 Feb 7.
    Department of Orthopedic Surgery, Mount Sinai Beth Israel, New York, NY, USA. Electronic address:
    Background: We report our experience with a bridging multimodal pain management program that provides comprehensive 48-hour pain control in patients undergoing total shoulder replacement (TSR).

    Methods: The study included all patients undergoing unilateral TSR by 1 surgeon between May 2015 and April 2017. There were 62 patients (23 men, 39 women) with an average age of 68 years (range 38-92 years). Read More

    Variation in the diagnosis and clinical management of Lentigo Maligna across Europe: a survey study among EADV members.
    J Eur Acad Dermatol Venereol 2018 Feb 8. Epub 2018 Feb 8.
    Dermatologist, Department of Dermatology, Erasmus Medical Center Rotterdam, The Netherlands.
    Background: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion and comparative studies are lacking. Read More

    The efficacy and safety of using cooled radiofrequency in treating chronic sacroiliac joint pain: A PRISMA-compliant meta-analysis.
    Medicine (Baltimore) 2018 Feb;97(6):e9809
    The Spine Center, Department of Orthopedics, Zhong-Da Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
    Background: Cooled radiofrequency procedure is a novel minimally invasive surgical technique and has been occasionally utilized in managing chronic sacroiliac joint (SIJ) pain. A meta-analysis was conducted to systematically assess the efficacy and safety of using cooled radiofrequency in treating patients with chronic SIJ pain in terms of pain and disability relief, patients' satisfaction degree as well as complications.

    Methods: Studies of using cooled radiofrequency procedure in managing SIJ pain were retrieved from Medline and Web of Science according to inclusion and exclusion criteria. Read More

    Risk factors for anthroponotic cutaneous leishmaniasis in unresponsive and responsive patients in a major focus, southeast of Iran.
    PLoS One 2018 7;13(2):e0192236. Epub 2018 Feb 7.
    Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
    Cutaneous leishmaniasis (CL) is a serious health challenge at the global level due to Leishmania tropica. This study was conducted to evaluate the risk factors associated with anthroponotic CL (ACL) in unresponsive (patient who does not heal and remains with an active lesion, despite receiving two courses of intra-lesional Glucantime along with cryotherapy and one cycle of systemic Glucantime) and responsive patients in a major focus in southeastern Iran. A case-control study was conducted from April 2015 to October 2016 in the southeast of Iran. Read More

    Successful cryoablation of breast cancer.
    Breast J 2018 Feb 7. Epub 2018 Feb 7.
    Diagnostic Center for Women, Miami, FL, USA.
    The current standard of care for screen-detected breast cancers is surgical excision. Cryotherapy is a promising non- surgical alternative treatment for these cancers and is performed under local anesthesia as an outpatient, circumventing the risks that come with an operation. New research also shows promising results for the treatment of breast cancer when cryotherapy is combined with immune modulation as it may help prevent tumor recurrence. Read More

    Effects of microcurrent and cryotherapy on C-reactive protein levels and muscle tone of patients with rotator cuff reconstruction.
    J Phys Ther Sci 2018 Jan 27;30(1):37-41. Epub 2018 Jan 27.
    Department of Physical Therapy, Mokpo Mirae Hospital: 351 Seokhyeon-dong, Mokpo-si, Jeonnam 530-828, Republic of Korea.
    [Purpose] The purpose of the present study was to apply early intervention via microcurrent and cryotherapy in patients who underwent rotator cuff reconstruction surgery, and to investigate the effects of such interventions on pain and inflammation levels based on the analysis of C-reactive protein (CRP) levels, and on changes in muscle tone. [Subjects and Methods] The study population consisted of 30 patients who had undergone rotator cuff reconstruction surgery, with 10 patients each assigned to the control, experimental I (E-1), and experimental II (E-II) groups. On the day after surgery, muscle tone, blood CRP level, and pain were measured. Read More

    Cryotherapy by encapsulation-dehydration is effective for in vitro eradication of latent viruses from 'Marubakaido' apple rootstock.
    J Biotechnol 2018 Mar 4;269:1-7. Epub 2018 Feb 4.
    Santa Catarina State University (UDESC), Lages, Santa Catarina, 88520000, Brazil.
    Apple stem pitting virus (ASPV), Apple chlorotic leaf spot virus (ACLSV) and Apple stem grooving virus (ASGV) are several major viral pathogens of apple trees, responsible for substantial damage to the world's apple industry. This study aimed to evaluate the effectiveness of the encapsulation-dehydration cryopreservation technique to eradicate these viral pathogens from in vitro shoot tips excised from 'Marubakaido' apple rootstock cultures. Axillary shoot tips were excised from in vitro cultures, encapsulated in alginate beads, precultured in MS salts, dehydrated in a laminar flow hood, immersed in liquid nitrogen, then warmed and recovered on medium. Read More

    Effects of Various Cryotherapy Applications on Postoperative Pain in Molar Teeth with Symptomatic Apical Periodontitis: A Preliminary Randomized Prospective Clinical Trial.
    J Endod 2018 Feb 2. Epub 2018 Feb 2.
    Department of Endodontics, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. Electronic address:
    Introduction: The purpose of the study was to evaluate the effects of intracanal, intraoral, and extraoral cryotherapy on postoperative pain in molar teeth with symptomatic apical periodontitis.

    Methods: A total of 100 patients were randomly distributed into 4 groups: control (without cryotherapy application), intracanal cryotherapy application, intraoral cryotherapy application, and extraoral cryotherapy application. The postoperative pain of the patients was recorded at the first, third, fifth, and seventh days. Read More

    Oral lymphangiectasias and Crohn's disease: two case reports.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Oral and Maxillofacial Surgery, South Eastern Health and Social Care Trust, Belfast, Northern Ireland.
    Lymphangiectasias, or acquired lymphangiomas, are rare in the oral cavity, more typically occurring on the skin or the genital area and, to our knowledge, have not been reported previously in association with Crohn's disease. Lymphangiectasias can occur at any age and develop secondary to chronic obstruction of the lymphatics. This differentiates them from congenital lymphangiomas, which are congenital malformations of the lymphatic system. Read More

    Defect Reconstruction of the Nose After Surgery for Nonmelanoma Skin Cancer: Our Clinical Experience.
    Turk Arch Otorhinolaryngol 2017 Sep 1;55(3):111-118. Epub 2017 Sep 1.
    Department of Otorhinolaryngology, Ege University School of Medicine, İzmir, Turkey.
    Objective: This study aimed to investigate reconstruction methods according to nasal subunits in patients who were surgically treated with diagnosis of non-melanoma skin cancer of the nose.

    Methods: All patients were retrospectively investigated. This study was conducted between April 2004 and December 2010; 180 patients who were surgically treated with diagnoses of skin basal cell carcinoma, squamous cell carcinoma, cancer of skin appendages, and precancerous lesions and 194 lesions were included. Read More

    Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8656
    Rationale: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Read More

    Clinical features and treatment outcomes of vasoproliferative tumors in Indian participants.
    Indian J Ophthalmol 2018 Feb;66(2):246-251
    Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Purpose: The aim of the study was to describe the clinical features and treatment outcomes of vasoproliferative tumors (VPT) in Indian participants.

    Methods: This study design was a retrospective case series in a tertiary eye care center. Case records of patients diagnosed with VPT from 2011 to 2015 were reviewed, and their demographic details, clinical presentation, and treatment outcomes were documented. Read More

    [The feasibility of the application of cryotherapy and radonotherapy for the treatment of the patients presenting with osteoarthritis].
    Vopr Kurortol Fizioter Lech Fiz Kult 2017 Dec 5;94(5):58-66. Epub 2017 Dec 5.
    Moscow Scientific and Practical Centre for Medical Rehabilitation, Restorative and Sports Medicine.
    Osteoarthritis (OA) is currently considered to be one of the most widespread diseases. Its main clinical symptoms include pain and dysfunction of joints. In the present review of the foreign and domestic literature, the questions of pathogenesis and risk factors underlying the development of osteoarthritis are discussed. Read More

    Cryosurgery in the excision of a giant local recurrent sacral chordoma: a case report and literature review.
    Eur Spine J 2018 Jan 25. Epub 2018 Jan 25.
    Department of Oncologic and Degenerative Spine Surgery, Rizzoli Orthopedic Institute, Via G.C. Pupilli 1, 40136, Bologna, Italy.
    Purpose: Chordoma is a low-grade malignant tumor with recurrence and metastasis tendency that originates from embryonic notochordal remnants. The sacrococcygeal region is the most commonly involved site. The aim of this paper is to report the results of the use of cryosurgery in the excision of a giant recurrent sacral chordoma and review of pertinent literature. Read More

    Pulsed-dye laser therapy for carcinoma in situ of the penis.
    Br J Dermatol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    Carcinoma in situ (CIS) of the penis is a precancerous condition with a 5 to 10% risk for progression into an invasive penile squamous cell carcinoma (SCC). Clinical variants of genital CIS encompass bowenoid papulosis, erythroplasia of Queyrat and Bowen's disease. Treatment options of penile CIS include topical application of 5-fluorouracil (5-FU) or imiquimod, photodynamic therapy (PDT), ablative laser therapy, cryotherapy and surgery. Read More

    Long-Term Outcomes of Total Exudative Retinal Detachments in Stage 3B Coats Disease.
    Ophthalmology 2018 Jan 17. Epub 2018 Jan 17.
    Long Island Vitreoretinal Consultants, Great Neck, New York. Electronic address:
    Purpose: To evaluate the long-term outcomes of treatment of total exudative retinal detachments (ERDs) secondary to Coats disease (stage 3B) and the role of vitrectomy.

    Design: Retrospective, observational case series.

    Participants: A total of 16 eyes in 16 patients undergoing treatment for total ERDs secondary to Coats disease with at least 5 years of follow-up. Read More

    Impact of a new cryotherapy device on early rehabilitation after primary total knee arthroplasty (TKA): a prospective randomised controlled trial.
    Int Orthop 2018 Jan 22. Epub 2018 Jan 22.
    Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
    Background: The aim of this prospective, randomised and single blinded study was to evaluate the efficiency and safety of a new cryotherapy device in patients undergoing unilateral, primary total knee arthroplasty (TKA). Our hypothesis was that patients administered to the new cryotherapy device would perform better than patients receiving a conventional standard cold therapy regimen.

    Methods: Ninety-seven patients were randomised into two groups receiving either the cTreatment® (new cryotherapy device) or the standard cold therapy protocol (including cold pack application for six days after the surgical intervention). Read More

    Liquid Nitrogen Spray Cryotherapy is Associated With Less Postprocedural Pain Than Radiofrequency Ablation in Barrett's Esophagus: A Multicenter Prospective Study.
    J Clin Gastroenterol 2018 Jan 18. Epub 2018 Jan 18.
    Division of Gastroenterology, Long Island Jewish Medical Center, Hofstra Northwell School of Medicine, Northwell Health System, New Hyde Park, NY.
    Goals And Background: Two common endoscopic therapies for eradication of dysplastic Barrett's esophagus are radiofrequency ablation (RFA) and liquid nitrogen spray cryotherapy (LNC). There is no data comparing postprocedural pain. This study aimed to compare the incidence of postprocedural pain between the 2 ablation modalities. Read More

    Procedural Knowledge and Skills of Residents Entering Canadian Family Medicine Programs in Alberta.
    Fam Med 2018 Jan;50(1):10-21
    Department of Family Medicine, Faculty of Medicine, University of Calgary.
    Background And Objectives: Incoming family medicine (FM) residents start residency with different levels of procedural training. Understanding their baseline skill level is necessary to plan the educational experiences and teaching methods that will provide the desired knowledge, skills, and attitudes related to performing medical procedures.

    Methods: A survey of 69 procedures based on the core list issued by the College of Family Physicians of Canada was administered to incoming residents in Alberta (Calgary and Edmonton FM programs). Read More

    Novel dry cryotherapy system for cooling the equine digit.
    Vet Rec Open 2018 7;5(1):e000244. Epub 2018 Jan 7.
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
    Objectives: Digital cryotherapy is commonly used for laminitis prophylaxis and treatment. Currently validated methods for distal limb cryotherapy involve wet application or compression technology. There is a need for a practical, affordable, dry cryotherapy method that effectively cools the digit. Read More

    Knowledge and practices of general practitioners at district hospitals towards cervical cancer prevention in Burundi, 2015: a cross-sectional study.
    Global Health 2018 Jan 16;14(1). Epub 2018 Jan 16.
    Faculty of Medicine and health sciences, Global Health Institute, University of Antwerp, Antwerp, Belgium.
    Background: Well-organized screening and treatment programmes are effective to prevent Invasive Cervical Cancer (ICC) in LMICs. To achieve this, the World Health Organization (WHO) recommends the involvement of existing health personnel in casu doctors, nurses, midwives in ICC prevention. A necessary precondition is that health personnel have appropriate knowledge about ICC. Read More

    Ice pack induced perineal analgesia after spontaneous vaginal birth: Randomized controlled trial.
    Women Birth 2018 Jan 11. Epub 2018 Jan 11.
    School of Medicine, Municipal University of Sao Caetano do Sul, Av. Goiás, 3400, São Caetano do Sul, SP, CEP 09550-051, Brazil. Electronic address:
    Background: Ice-pack is widely used for alleviating postpartum perineal pain sustained after birth related perineal trauma. However, it lacks robust evidence on timing and frequency of applications, to ensure the effective and safe use of this therapy.

    Aims: To evaluate if a 10min ice-pack application relieved postpartum perineal pain and if the analgesic effect was maintained for up to 2h. Read More

    Applying Sutureless Encircling Number 41 Band and Transscleral Chandelier-Assisted Laser Retinopexy for Scleral Buckling Procedure.
    J Ophthalmol 2017 30;2017:4671305. Epub 2017 Nov 30.
    Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Purpose: To assess the outcome of sutureless encirlcing number 41 band and transscleral laser retinopexy in uncomplicated rhegmatogenous retinal detachment (RRD), using a wide-angle viewing system (WAVS) and chandelier endoillumination.

    Methods: Prospective intervention study included 30 eyes of 30 patients presenting with RRD of recent onset indicated for SB. All cases were treated by sutureless encircling number 41 band and transscleral laser retinopexy. Read More

    Cryobiotechnology of apple (Malus spp.): development, progress and future prospects.
    Plant Cell Rep 2018 Jan 11. Epub 2018 Jan 11.
    State Key Laboratory of Crop Stress Biology in Arid Region, College of Horticulture, Northwest Agriculture & Forestry University, Yangling, 712100, Shaanxi, People's Republic of China.
    Key Message: Cryopreservation provides valuable genes for further breeding of elite cultivars, and cryotherapy improves the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. Apple (Malus spp. Read More

    Controlling the error on target motion through real-time mesh adaptation: applications to Deep Brain Stimulation.
    Int J Numer Method Biomed Eng 2018 Jan 5. Epub 2018 Jan 5.
    Institute of Computational Engineering, University of Luxembourg, Faculty of Sciences Communication and Technology, Luxembourg.
    An error-controlled mesh refinement procedure for needle insertion simulations is presented. As an example, the procedure is applied for simulations of electrode implantation for Deep Brain Stimulation. We take into account the brain shift phenomena occurring when a craniotomy is performed. Read More

    Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma.
    Am J Orthop (Belle Mead NJ) 2017 Nov/Dec;46(6):E463-E467
    Department of Orthopaedics, Ohio State University Wexner Medical Center, Columbus, OH.
    In this article, we report a case of transformation of a benign giant cell tumor (GCT) of the calcaneus into an epithelioid angiosarcoma. The patient presented to our service in 2003 and was followed until 2014. Transformation occurred 11 years after curettage, cryotherapy, cementation, and a well-documented disease-free interval. Read More

    Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity.
    Cochrane Database Syst Rev 2018 01 8;1:CD009734. Epub 2018 Jan 8.
    Newborn Health Knowledge Centre, WHO Collaborating Centre for Training and Research in Newborn Care, Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India.
    Background: Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in foetal life. Researchers have recently attempted to use anti-VEGF agents for the treatment of retinopathy of prematurity (ROP), a vasoproliferative disorder. The safety and efficacy of these agents in preterm infants with ROP is currently uncertain. Read More

    Epidemiological Trends of Cutaneous Leishmaniasis in Al-Madinah Al-Munawarah Province, Western Region of Saudi Arabia.
    J Glob Infect Dis 2017 Oct-Dec;9(4):146-150
    Department of medicine, Meeqat Hospital, Al-Madinah Al-Munawarah, KSA.
    Objective: To investigate the epidemiological trends of cutaneous leishmaniasis (CL) in Al-Madinah Al-Munawarah, western region of KSA.

    Materials And Methods: Four hundred and sixty-seven parasitologically confirmed CL cases attending Al-Meeqat Hospital, Al-Madinah, during 2012-2015, were included in this study.

    Results: Both Saudi and non-Saudi nationals were infected, with the highest infection rate being among Saudis (68. Read More

    Xanthelasma palpebrarum - a brief review.
    Clin Cosmet Investig Dermatol 2018 18;11:1-5. Epub 2017 Dec 18.
    Department of Dermatology, Venereology and Leprosy, Pramukhswami Medical College, Gujarat, India.
    Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Read More

    Kaposi Sarcoma After Allogeneic Hematopoietic Stem Cell Transplant: A Rare Complication.
    Exp Clin Transplant 2018 Jan 2. Epub 2018 Jan 2.
    From the Hematology Research Center, Department of Hematology, Medical Oncology and Stem Cell Transplantation; Shiraz University of Medical Sciences, Shiraz, Iran.
    Kaposi sarcoma is a multicentric angioproliferative neoplasm of lymphatic endothelium-derived cells. Although this malignancy is relatively frequent after solid-organ transplant, it is extremely rare after bone marrow transplantation. Allogeneic stem cell transplantation is associated with severe prolonged immunosuppression; however, a few cases of Kaposi sarcoma after hematopoietic stem cell transplant were previously reported. Read More

    [Retinal hemangioblastoma: Treatment strategy and long-term follow-up in a retrospective cohort].
    J Fr Ophtalmol 2017 Dec 28. Epub 2017 Dec 28.
    Service d'ophtlamologie, hôpital de la Croix-Rousse, 103, Grande-Rue de la Croix-Rousse, 69004 Lyon, France; Université Lyon-1, 8, avenue Rockefeller, 69003 Lyon, France.
    Introduction: Retinal hemangioblastoma (RH) is a benign vascular tumor frequently associated with Von Hippel-Lindau disease (VHL). Tumor growth of RH may lead to deterioration of visual acuity, which can be difficult to treat. Early diagnosis may reduce complication rate and side effects of treatment. Read More

    Clinical management and risk reduction in women with low-grade squamous intraepithelial lesion cytology: A population-based cohort study.
    PLoS One 2017 28;12(12):e0188203. Epub 2017 Dec 28.
    Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
    We analyzed the management and risk of subsequent cervical intraepithelial neoplasm 3 (CIN3) and invasive cervical cancer in women with low-grade squamous intraepithelial lesion (LSIL) cytology. A total of 53,293 women with a new diagnosis of cytologic LSIL were identified in Taiwan's national cervical screening registration database. Based on the retrieved clinical management data, the incidence of subsequent CIN3+ lesions was determined, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model. Read More

    Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?
    Indian J Ophthalmol 2018 Jan;66(1):55-60
    Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center; Department of Ophthalmology, The New York Eye and Ear Infirmary of Mt. Sinai, New York, NY, USA.
    Purpose: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN).

    Methods: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications. Read More

    Effect of Continuous Digital Hypothermia on Lamellar Inflammatory Signaling When Applied at a Clinically-Relevant Timepoint in the Oligofructose Laminitis Model.
    J Vet Intern Med 2018 Jan 27;32(1):450-458. Epub 2017 Dec 27.
    Department of Veterinary Clinical Sciences, Ohio State University, Columbus, OH, USA.
    Background: Although continuous digital hypothermia (CDH) protects lamellae from injury in the oligofructose (OF) model of sepsis-related laminitis (SRL), conflicting results exist from these studies regarding effects of CDH on lamellar inflammatory events.

    Hypothesis/objectives: To determine the effect of CDH on lamellar inflammatory events in normal and OF-treated horses when instituted at a clinically relevant time point (onset of clinical signs of sepsis in this model).

    Animals: Standardbred geldings (n = 15) aged 3-11 years were used. Read More

    Outcomes of Pneumatic Retinopexy for the Management of Rhegmatogenous Retinal Detachment at a Tertiary Care Center.
    Middle East Afr J Ophthalmol 2017 Jul-Sep;24(3):143-147
    Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
    Purpose: The purpose of the study was to report the outcomes of pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD).

    Methods: A retrospective chart review of all patients with RRD who were managed with PR at the King Khaled Eye Specialist Hospital between 2000 and 2014. Data were collected on preoperative ocular history, characteristics of the RRD, postoperative anatomical and visual outcomes, and secondary surgeries. Read More

    Effects of Focal vs Total Cryotherapy and Minimum Tumor Temperature on Patient-reported Quality of Life Compared With Active Surveillance in Patients With Prostate Cancer.
    Urology 2017 Dec 23. Epub 2017 Dec 23.
    Stony Brook University School of Medicine, Stony Brook, NY; Department of Urology, NYU-Winthrop Hospital, Mineola, NY.
    Objective: To investigate the effects of focal (hemiablation) or total cryotherapy and minimum tumor temperature on patient-reported quality of life (QoL) in patients with prostate cancer.

    Methods: An Institutional Review Board-approved database was reviewed for patients who underwent cryotherapy or active surveillance (AS). QoL questionnaire responses were collected and scores were analyzed for differences between focal and total cryotherapy and between very cold (<-76°C) and moderate-cold (≥-76°C) minimum tumor temperatures. Read More

    A comparison of time taken to return to baseline erectile function following focal and whole gland ablative therapies for localized prostate cancer: A systematic review.
    Urol Oncol 2018 Feb 23;36(2):67-76. Epub 2017 Dec 23.
    Department of Urology, University College London Hospital NHS Foundation Trust, London, UK.
    Objectives: To systematically review erectile function (EF) outcomes following primary whole gland (WG) and focal ablative therapies for localized prostate cancer to ascertain whether the treatment modality or intended treatment volume affects the time taken to recover baseline EF.

    Method And Materials: A systematic review was performed according to the preferred reporting items for systematic review and meta-analysis statement. Inclusion criteria were men with localized prostate cancer treated with primary, ablative therapy. Read More

    Management of Chronic Lateral Epicondylitis With Manual Therapy and Local Cryostimulation: A Pilot Study.
    J Chiropr Med 2017 Dec 11;16(4):279-288. Epub 2017 Oct 11.
    Human Kinetics Department, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
    Objective: The purpose of this pilot study was to evaluate the feasibility and efficacy of adding cryostimulation to manual therapy in patients with chronic lateral epicondylitis.

    Methods: The control group (n = 19) was treated with manual therapy consisting of soft-tissue therapy and radial head mobilizations. The experimental group (n = 18) received cryostimulation in addition to manual therapy care similar to that for the control group. Read More

    Emerging Unconventional Therapies for Alopecia Areata.
    J Investig Dermatol Symp Proc 2018 Jan;19(1):S32-S33
    Department of Dermatology, University of California, Irvine, California, USA. Electronic address:
    Alopecia areata is a prevalent autoimmune skin disease with no cure or indicated treatment options. In the absence of an approved treatment, some patients are eager to try unconventional therapies, despite the very limited research evaluating their safety and efficacy. Recently emerging unconventional therapies for alopecia areata discussed include antihistamines, cryotherapy, and low-dose naltrexone. Read More

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