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    1 OF 552

    Recent perspectives of management of breast cancer metastasis - an update.
    J BUON 2017 Mar-Apr;22(2):295-300
    Department of Oncological Surgery 2, Xuzhou City Central Hospital, the affiliated Hospital of the Southeast University Medical School (Xu zhou), the Tumor Research Institute of the Southeast University (Xu zhou), Xuzhou Jiangsu 221009, China.
    Breast cancer is the leading cause of cancer related deaths in women and one of the most common cancers globally. The major obstacle in the management of breast cancer, especially at advanced stages, is metastasis. Metastasis in the advanced stages of breast cancer could decrease survival to approximately 5 years. Read More

    Sequential pars plana vitrectomy and cataract extraction with intraocular lens implantation in patient with corneal inlay who developed retinal detachment followed by cataract.
    J Cataract Refract Surg 2017 Apr;43(4):570-571
    From the Department of Ophthalmology (Jabbur, Awwad, Bashshur), American University of Beirut Medical Center, and the Department of Ophthalmology (Jabbur), Clemenceau Medical Center, Beirut, Lebanon. Electronic address:
    Twenty-one months after successful small-aperture corneal inlay (Kamra) implantation simultaneous with myopic laser in situ keratomileusis, a patient presented with a superior rhegmatogenous macula-involving retinal detachment. Successful pars plana vitrectomy, transscleral cryotherapy, and gas tamponade were performed with the inlay in situ. Three months later, uneventful phacoemulsification and posterior chamber intraocular lens implantation were performed, also with the inlay in situ, for a visually significant cataract. Read More

    The effects of a treatment combination of anti-VEGF injections, laser coagulation and cryotherapy on patients with type 3 Coat's disease.
    BMC Ophthalmol 2017 May 22;17(1):76. Epub 2017 May 22.
    Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University, No. 1 Dongjiao Min Xiang, 100730, Beijing, People's Republic of China.
    Background: To examined the curative effect of vitreous injection with ranibizumab,laser coagulation and cryotherapy in treating stage 3 Coats' disease with exudative retinal detachment.

    Methods: Seventeen patients with stage 3 Coats' disease were enrolled in the study. All eyes were treated with vitreous injection of ranibizumab as initial treatment, and subsequent treatment depended on the absorption of subretinal fluid, Including cryotherapy and laser photocoagulation. Read More

    Massive ear keloids: Natural history, evaluation of risk factors and recommendation for preventive measures - A retrospective case series.
    F1000Res 2016 13;5:2517. Epub 2016 Oct 13.
    Keloid Research Foundation, New York, NY, 10023, USA.
    Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians.  Genetics of this disorder continues to be obscure and poorly understood.  Clinical manifestation of KD is quite variable and very diverse, spanning from individuals with one or very few small keloidal lesions, to those with numerous and very large lesions covering large portion of their skin. Read More

    Acute Exacerbation of Interstitial Lung Disease After Cryobiopsy.
    J Bronchology Interv Pulmonol 2017 May 18. Epub 2017 May 18.
    *Division of Pulmonary, Allergy, Critical Care and Sleep Medicine †Department of Internal Medicine ‡Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
    Cryotherapy has been used in treatment of lung cancer for decades. The utility of cryotechnology in diagnosis of lung diseases is emerging and gaining popularity. Cryobiopsy (CB) of the lung, when compared with conventional transbronchial forceps lung biopsy, has proposed to have a higher diagnostic yield in interstitial lung disease by providing larger biopsy specimen and less crush artifact. Read More

    A case series of verrucae vulgares mimicking hyperkeratosis in individuals with diabetic foot ulcers.
    Diabet Med 2017 May 19. Epub 2017 May 19.
    Diabetes Division, Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum.
    Background: Diabetic foot ulcers are a common complication in the advanced stages of diabetes mellitus. Certain lesions may be refractory to usual treatments with prolonged healing. In these cases, differential diagnoses to classical ulcers should be considered. Read More

    Molluscum contagiosum: an update.
    Recent Pat Inflamm Allergy Drug Discov 2017 May 17. Epub 2017 May 17.
    Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.
    Background: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition.

    Objective: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. Read More

    Large Bowel Obstruction following Endoscopic Spray Cryotherapy for Palliation of Rectal Cancer Bleeding.
    ACG Case Rep J 2017 10;4:e65. Epub 2017 May 10.
    Department of Gastroenterology, Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL.
    We report a unique case of a 79-year-old woman with metastatic rectal cancer who developed bowel obstruction following endoscopic cryotherapy with liquid nitrogen for palliation of bleeding in the rectum. She developed abdominal distention and pain following the procedure. Computed tomography of the abdomen revealed a paraumbilical hernia containing a segment of transverse colon resulting in partial bowel obstruction. Read More

    Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature.
    Front Physiol 2017 2;8:258. Epub 2017 May 2.
    Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico GaleazziMilan, Italy.
    Nowadays, whole-body cryotherapy is a medical physical treatment widely used in sports medicine. Recovery from injuries (e.g. Read More

    A Comparative Study of Liquid Nitrogen Cryotherapy as Monotherapy versus in Combination with Podophyllin in the Treatment of Condyloma Acuminata.
    J Clin Diagn Res 2017 Mar 1;11(3):WC01-WC05. Epub 2017 Mar 1.
    Junior Resident, Department of Dermatology, Government Medical College, Amritsar, Punjab. India.
    Introduction: Condyloma Acuminata (CA) is a common viral sexually transmitted disease. Although various treatment modalities are available for treating CA, but none of them can achieve 100% response rate. In a search for better response rate and less recurrence rate, the combination of cytotoxic agent Podophyllin with ablative liquid nitrogen cryotherapy was evaluated over cryotherapy alone. Read More

    Long-term Visual Acuity, Strabismus and Nystagmus Outcomes Following Multimodality Treatment in Group D Retinoblastoma Eyes.
    Am J Ophthalmol 2017 May 10. Epub 2017 May 10.
    Moorfields Eye Hospital; Retinoblastoma Service, Royal London Hospital, London, UK; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
    Purpose: To analyse the long-term visual acuity, strabismus and nystagmus outcomes in Group D retinoblastoma following multimodality treatments in a national retinoblastoma referral centre.

    Design: Retrospective interventional case series.

    Methods: A 13-year retrospective chart review of Group D eyes treated initially with intravenous chemotherapy (IVC) and followed-up for at least 1 year from last treatment. Read More

    Vertebroplasty and interventional radiology procedures for bone metastases.
    Joint Bone Spine 2017 May 9. Epub 2017 May 9.
    Service de Radiologie, Hôpital Lariboisière, APHP et Université Paris-Diderot, 2, rue Ambroise Paré, 75010, Paris, France.
    Advances in cancer treatments have lengthened the survival of patients with bone metastases. Optimal control of the symptoms and prevention of the complications associated with bone metastases improve quality of life. Achieving these goals increasingly involves interventional radiology procedures. Read More

    Post-operative interventions to reduce inflammatory complications after third molar surgery: Review of the current evidence.
    Aust Dent J 2017 May 12. Epub 2017 May 12.
    Maxillofacial Unit, Royal Brisbane and Women's Hospital, Brisbane, Australia.
    Background: Inflammatory complications such as pain, swelling, trismus, infection and alveolar osteitis, have an adverse affect on the quality of life of patients after third molar removal. This review presents the current evidence on post-operative strategies to reduce these complications.

    Methods: A literature search was performed to identify articles published in English between 2000 to 2016 using the following key words: third molar(s), wisdom tooth/teeth, pain, swelling, trismus, infection, alveolar osteitis, and dry socket. Read More

    Effect of whole-body cryotherapy on the rheological parameters of blood in older women with spondyloarthrosis.
    Clin Hemorheol Microcirc 2017 May 2. Epub 2017 May 2.
    Department of Clinical Rehabilitation, Faculty of Motor Rehabilitation, University of Physical Education, Krakow, Poland.
    Background: Cryotherapy is a physiotherapy method used to treat back pain in older persons.

    Objective: This study aims to evaluate the changes in the rheological parameters of blood in older women with spondyloarthrosis, who underwent whole-body cryotherapy.

    Methods: The experimental group comprised 69 older women with lumbar spondyloarthrosis, aged between 65 and 70 years. Read More

    Orf virus infection.
    Rev Med Virol 2017 May 8. Epub 2017 May 8.
    Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.
    Orf virus (ORFV) is an important pathogen responsible for a highly contagious zoonotic viral infection that threatens those who handle sheep and goats. Orf virus is the prototype of the Parapoxvirus genus, and its resilience in the environment and ability to reinfect its host has contributed to the spread and maintenance of the infection in many species. In healthy humans, the disease usually resolves spontaneously within 3 to 6 weeks. Read More

    Effects of lymphatic drainage and cryotherapy on indirect markers of muscle damage.
    J Sports Med Phys Fitness 2017 May 5. Epub 2017 May 5.
    Institute of Training Science and Sport Informatics, German Sport University Cologne, Cologne, Germany.
    Background: Muscle enzymes are cleared from the extracellular space by the lymphatic system, while smaller proteins enter the bloodstream directly. We investigated if manual lymphatic drainage (MLD), local cryotherapy (CRY), and rest (RST) differently affect the time course of creatine kinase (CK, 84 kDa) and heart-type fatty acid binding protein (h-FABP, 15 kDa) in the blood.

    Design: Randomized controlled trial. Read More

    [Percutaneous lung thermo-ablation].
    Bull Cancer 2017 May 3. Epub 2017 May 3.
    Institut Gustave-Roussy, département d'imagerie, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
    Percutaneous lung thermo-ablation has steadily been developed over the past 15years. Main indications are early stage non-small cell lung carcinoma (NSCLC) for non-surgical patients and slow evolving localized metastatic disease, either spontaneous or following a general treatment. Radiofrequency, being the most evaluated technique, offers a local control rate of about 80-90% for tumors <3 cm in diameter. Read More

    Small cryotherapy devices for the treatment of skin warts.
    J Dermatolog Treat 2017 May 16:1-6. Epub 2017 May 16.
    b Departments of Dermatology, Venereology, Allergology and Immunology , Dessau Medical Center, Theodore Fontane Medical University of Brandenburg , Dessau , Germany.
    Study Purpose: Effectiveness of cryotherapy on skin wart models.

    Materials And Methods: Two small cryotherapy devices, Wartner and Wortie, were administered for 10″-60″ on tomatoes and potatoes used as skin wart models. Frozen surface and depth were evaluated by standardized photography and computer analysis. Read More

    Efficacy of Nd:YAG laser therapy for the treatment of verrucae: a literature review.
    Lasers Med Sci 2017 May 2. Epub 2017 May 2.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Suite 2175, Miami, FL, 33136, USA.
    Verrucae are benign epithelial proliferations, characteristically 1-20 mm in diameter, caused by human papilloma virus (HPV) infection occurring on the skin and mucosa (Photomed Laser Surg 33(6):338-42, 2015; Lasers Med Sci 29(3):1111-6, 2014). Prevalence of verrucae is 5-20% in children and young adults with peak incidence reported during teenage years (Lasers Med Sci 29(3):1111-6, 2014; J Am Acad Dermatol 22(4):547-66, 1990; J Korean Med Sci 24(5):889-93, 2009). Patients often express significant displeasure with quality of life due to this cosmetic insecurity, as well as functional problems and physical discomfort when they occur on palms of hands and soles of feet. Read More

    Cryotherapy With Dynamic Intermittent Compression Improves Recovery From Revision Total Knee Arthroplasty.
    J Arthroplasty 2017 Mar 31. Epub 2017 Mar 31.
    Département de chirurgie Orthopédique et Traumatologique, CHU Toulouse, Toulouse, France.
    Background: The goal of this study was to assess the efficacy of cryotherapy with dynamic intermittent compression (CDIC) in relieving postoperative pain, decreasing blood loss, and improving functional scores after revision total knee arthroplasty (rTKA).

    Methods: We conducted a prospective case-control study (level of evidence: I) to evaluate the efficacy of CDIC on postoperative bleeding, pain, and functional outcomes after rTKA. Forty-three cases were included at a single institution and divided in 2 groups: a control group without CDIC (n = 19) and an experimental group with CDIC (n = 24). Read More

    Editorial Comment on END-2016-0830-OR.R1.
    J Endourol 2017 May 2. Epub 2017 May 2.
    University of Western Ontario, Urology , 800 Commissioners Road , E2-650 , London, Ontario, Canada , N6A 4G5 ;
    "Focal therapy/Partial Ablation" for prostate cancer now garners significant attention and controversy. Critics and skeptics point to the known multifocality nature of prostate cancer, countered by proponents of focal therapy with the "dominant index lesion versus secondary lesions" theory. Tay et al. Read More

    Intramuscular hemangiomas on the masseter muscle and orbicularis oris muscle: a report of two cases.
    J Korean Assoc Oral Maxillofac Surg 2017 Apr 25;43(2):125-133. Epub 2017 Apr 25.
    Department of Pathology, Inha University School of Medicine, Incheon, Korea.
    Intramuscular hemangioma (IMH) is a rare vascular disease involving skeletal muscle, comprising only 0.8% of hemangiomas. About 10% to 15% of IMHs occur in the head and neck region, mostly involving the masseter muscle. Read More

    Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis.
    Sex Med 2017 Apr 28. Epub 2017 Apr 28.
    The Centers for Vulvovaginal Disorders, Washington, DC, and New York, NY, USA; George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
    Desquamative inflammatory vaginitis is a poorly understood chronic vaginitis with an unknown etiology. Symptoms of desquamative inflammatory vaginitis include copious yellowish discharge, vulvovaginal discomfort, and dyspareunia. Cervical ectropion, the presence of glandular columnar cells on the ectocervix, has not been reported as a cause of desquamative inflammatory vaginitis. Read More

    Tetramethylpyrazine-mediated regulation of CXCR4 in retinoblastoma is sensitive to cell density.
    Mol Med Rep 2017 May 7;15(5):2481-2488. Epub 2017 Mar 7.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
    Retinoblastoma is the most common ocular tumor in children, and it causes extensive damage. Current treatment options for retinoblastoma include surgery, chemotherapy, radiotherapy and cryotherapy. However, the majority of chemotherapy medicines cause complications and side effects that lead to severe impairment of patient health. Read More

    Current status of spray cryotherapy for airway disease.
    J Thorac Dis 2017 Mar;9(Suppl 2):S122-S129
    Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
    The use of liquid nitrogen to treat skin and mucosal lesions is well understood in the dermatologic and gastrointestinal literature. Direct spray cryotherapy (SCT) in the airway has shown promising results in the treatment of esophageal premalignant and even invasive lesions. In the airway, several studies have shown it to be a safe, effective treatment for both benign and malignant disease. Read More

    Laparoscopic Versus Percutaneous Cryoablation of Small Renal Mass: Systematic Review and Cumulative Analysis of Comparative Studies.
    Clin Genitourin Cancer 2017 Mar 30. Epub 2017 Mar 30.
    Department of Urology, Denver Health Medical Center and University of Colorado Denver, Denver, CO.
    The objective of this study was to compare the surgical, oncological, and functional outcomes of laparoscopic and percutaneous cryoablation for the treatment of small renal masses. A systematic review of the literature was performed through March 2016 using PubMed, Scopus, and Ovid databases. Article selection proceeded according to the search strategy on the basis of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Read More

    Cryoablation in the management of Barrett's esophagus.
    Curr Opin Gastroenterol 2017 Apr 24. Epub 2017 Apr 24.
    aDepartment of Gastroenterology & Hepatology, St. Antonius Hospital, Nieuwegein bDepartment of Gastroenterology & Hepatology, University Medical Center, Utrecht, The Netherlands.
    Purpose Of Review: Providing an overview on types of cryotherapy for esophageal application and their role in the management of Barrett's esophagus.

    Recent Findings: Recent studies have involved multiple types of cryotherapy including cryospray techniques that use either liquid nitrogen or carbon dioxide as the cryogenic fluid, and the CryoBalloon focal ablation device that uses nitrous oxide. Overall, studies report cryotherapy to be safe and effective in eradicating Barrett's epithelium. Read More

    Prostate Specific Antigen Nadir of 0.1 or Less Is a Predictor of Treatment Success in Men Undergoing Salvage Whole Prostate Gland Cryoablation.
    J Endourol 2017 May;31(5):497-501
    1 Urology Department, Glickman Urological and Kidney Institute , Cleveland Clinic, Cleveland, Ohio.
    Purpose: To assess factors that affect prostate biopsy results following salvage whole gland cryoablation.

    Patients And Methods: One hundred seventy-four patients underwent prostate biopsy following salvage whole gland cryoablation of the prostate in the Cryo-OnLine Database registry. Wilcoxon rank-sum and χ(2) tests and logistic regression analysis were used to assess predictors of positive biopsy. Read More

    Long -Term Survival in Stage IV Esophageal Adenocarcinoma with Chemoradiation and Serial Endoscopic Cryoablation.
    Clin Endosc 2017 Apr 24. Epub 2017 Apr 24.
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
    Esophageal cancer has a poor overall prognosis and is frequently diagnosed at a late stage. Conventional treatment for metastatic esophageal cancer involves chemotherapy and radiation. Local disease control plays a significant role in improving survival. Read More

    Management Options for Biochemically Recurrent Prostate Cancer.
    Curr Treat Options Oncol 2017 May;18(5):26
    Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1906, Bethesda, 20892, USA.
    Prostate cancer is the most common solid tumor malignancy in men worldwide. Treatment with surgery and radiation can be curative in organ-confined disease. Unfortunately, about one third of men develop biochemically recurrent disease based only on rising prostate-specific antigen (PSA) in the absence of visible disease on conventional imaging. Read More

    Percutaneous Image-Guided Cryotherapy for Local Control of Recurrent Plexiform Schwannoma in a 3-Year-Old Male.
    J Vasc Interv Radiol 2017 May;28(5):766-768
    Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St., Gray 290, Boston, MA 02114; Division of Interventional Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St., Gray 290, Boston, MA 02114.

    Examination of Intramuscular and Skin Temperature Decreases Produced by the PowerPlay Intermittent Compression Cryotherapy.
    J Sport Rehabil 2017 Apr 19:1-18. Epub 2017 Apr 19.
    1 Sports Medicine & Rehabilitation Center, Moravian College, Bethlehem, PA.
    Context: Previous research has found ice bags are more effective at lowering intramuscular temperature than gel packs. Recent studies have evaluated intramuscular temperature cooling decreases of ice bag versus GameReady, and with the PowerPlay system wetted ice bag inserts, however intramuscular decreases elicited by PowerPlay with the standard frozel gel pack inserts have not been examined.

    Objective: Evaluate rate and magnitude of cooling using PowerPlay with frozen gel pack option (PP-gel), PowerPlay with wetted ice bag option (PP-ice), and control (no treatment) on skin and intramuscular temperature (2cm sub-adipose). Read More

    Postoperative complications with cryotherapy in bone tumors.
    J Bone Oncol 2017 Jun 6;7:13-17. Epub 2017 Apr 6.
    Department of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States.
    The technique of cryosurgery has been used to control local recurrence in a variety of benign and malignant bone tumors. Early studies revealed significant complication rates (25%) that included fracture, infection, and soft tissue injury. Our method of cryosurgery has yielded excellent tumor control with improved complication rates. Read More

    Salvage Surgery After Renal Mass Ablation.
    Urol Clin North Am 2017 May 14;44(2):305-312. Epub 2017 Mar 14.
    Department of Urology, Stephenson Cancer Center, The University of Oklahoma, 800 Northeast 10th Street, Suite 4300, Oklahoma City, OK 73104, USA. Electronic address:
    Thermal ablative techniques represent treatment options for patients with small renal masses who are not candidates for surgery. The oncologic efficacy of ablation has not been compared in a randomized fashion with nephron-sparing surgery, and the urologist must be knowledgeable regarding the workup and treatment of patients with suspected residual or recurrent tumor following these therapies. Surveillance of patients with tumor recurrence after ablation may be indicated in select circumstances. Read More

    Conjunctival Tumors: Review of Clinical Features, Risks, Biomarkers, and Outcomes--The 2017 J. Donald M. Gass Lecture.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):109-120
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.
    Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Read More

    [Chromomycosis acquired in a non-tropical area: A case report].
    Ann Dermatol Venereol 2017 Apr 7. Epub 2017 Apr 7.
    Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:
    Background: Chromomycosis, or chromoblastomycosis, is caused by cutaneous inoculation of dematiaceous fungi of telluric or plant origin. It is generally seen in tropical or subtropical zones. Treatment of the condition is known to be complex. Read More

    A case of tracheal leiomyoma misdiagnosed as asthma.
    Tuberk Toraks 2016 Dec;64(4):306-309
    Clinic of Interventional Pulmonology Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.
    Primary benign tumors of trachea are rare. Of them, tracheal leiomyoma, constitutes only 1% of all benign lower respiratory tract tumors. Here, we present a case of tracheal leiomyoma who has been receiving high doses of inhaled corticosteroids and bronchodilators for a year with a misdiagnosis of asthma. Read More

    Efficacy of Punch Reduction Prior to Cryotherapy in Patients with Viral Warts: A Case-Control Study in a Single Tertiary Center.
    Ann Dermatol 2017 Apr 24;29(2):200-205. Epub 2017 Mar 24.
    Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Cutaneous warts are a common complaint to visit dermatologic clinic and its course is variable, ranging from spontaneous resolution to a chronic condition refractory to treatment.

    Objective: To evaluate the efficacy and safety of punch biopsy for cutaneous warts.

    Methods: Thirty-nine patients who received punch biopsy for warts were reviewed through charts and photos. Read More

    The efficacy of cooling with phase change material for the treatment of exercise-induced muscle damage: pilot study.
    J Sports Sci 2017 Apr 10:1-7. Epub 2017 Apr 10.
    b Department of Sport , Exercise & Rehabilitation, Northumbria University , Newcastle upon Tyne , UK.
    Post-exercise cryotherapy treatments are typically short duration interventions. This study examined the efficacy of prolonged cooling using phase change material (PCM) on strength loss and pain after eccentric exercise. Eight adults performed 120 bilateral eccentric quadriceps contractions (90% MVC). Read More

    The incidence of nerve root injury by high-speed drill can be reduced by chilled saline irrigation in a rabbit model.
    Bone Joint J 2017 Apr;99-B(4):554-560
    Osaka City University Graduate School of Medicine, 1-5-7, Asahimachi, Abenoku, Osaka 545-8585, Japan.
    Aims: We aimed to evaluate the temperature around the nerve root during drilling of the lamina and to determine whether irrigation during drilling can reduce the chance of nerve root injury.

    Materials And Methods: Lumbar nerve roots were exposed to frictional heat by high-speed drilling of the lamina in a live rabbit model, with saline (room temperature (RT) or chilled saline) or without saline (control) irrigation. We measured temperatures surrounding the nerve root and made histological evaluations. Read More

    [Retinopathy of prematurity].
    J Fr Ophtalmol 2017 May 3;40(5):430-437. Epub 2017 Apr 3.
    Service d'ophtalmologie, centre EVICR.net APOCHU 86, centre hospitalier universitaire Amiens Picardie, 80054 Amiens cedex 1, France; Université de Picardie-Jules-Verne, chemin du Thil, 80025 Amiens, France.
    Retinopathy of prematurity is a retinal vasoproliferative disease affecting extremely preterm infants exposed to high concentrations of oxygen therapy. Infants born before 32 post-menstrual weeks or with a birth weight of less than 1500g should systematically have a dilated fundus examination. The time of screening and schedule for follow-up are guided by the various risk factors. Read More

    Propensity Score Matched Comparison of Partial to Whole Gland Cryotherapy for Intermediate-Risk Prostate Cancer: An analysis of the COLD registry data.
    J Endourol 2017 Apr 6. Epub 2017 Apr 6.
    The Cleveland Clinic, Glickman Urological & Kidney Institute, Cleveland, Ohio, United States ;
    Objective: To compare the oncological and functional outcomes of partial versus whole-gland cryotherapy for men with intermediate-risk prostate cancer.

    Subjects/patients: Men with intermediate-risk prostate cancer treated with primary prostate cryotherapy from 1993-2013 were selected from the Cryo On-Line Data Registry for a 1:1 matched comparison between those undergoing whole-gland and partial prostate cryotherapy (targeted-ablation, unilateral/bilateral nerve-sparing ablations). A propensity score was developed based on age, pre-biopsy serum PSA, biopsy Gleason score, clinical stage, prostate volume, neoadjuvant androgen deprivation status, year of surgery and pre-treatment potency. Read More

    A Network Meta-analysis of Non-melanoma Skin Cancer (NMSC) Treatments: Efficacy and Safety Assessment.
    J Cell Biochem 2017 Mar 29. Epub 2017 Mar 29.
    Department of Obstetrics, Jinan Maternity and Child Care Hospital, Jinan 250001, Shandong, China.
    The mainstream treatments for non-melanoma skin cancer (NMSC) include photodynamic therapy (PDT), surgery excision (SE), cryotherapy (CT), imiquimod (IM), radiotherapy (RT), 5-fluorouracil (FU) and vehicle (VE). Our network meta-analysis (NMA) was aimed at evaluating the efficacy and safety of these seven treatments and providing superior ones. After searching the trials from Embase and PubMed and screening with our criteria, we conducted the NMA with software R 3. Read More

    Cost-effectiveness of an HPV self-collection campaign in Uganda: comparing models for delivery of cervical cancer screening in a low-income setting.
    Health Policy Plan 2017 Feb 20. Epub 2017 Feb 20.
    Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Avenue, Boston, MA, USA.
    With the availability of a low-cost HPV DNA test that can be administered by either a healthcare provider or a woman herself, programme planners require information on the costs and cost-effectiveness of implementing cervical cancer screening programmes in low-resource settings under different models of healthcare delivery. Using data from the START-UP demonstration project and a micro-costing approach, we estimated the health and economic impact of once-in-a-lifetime HPV self-collection campaign relative to clinic-based provider-collection of HPV specimens in Uganda. We used an individual-based Monte Carlo simulation model of the natural history of HPV and cervical cancer to estimate lifetime health and economic outcomes associated with screening with HPV DNA testing once in a lifetime (clinic-based provider-collection vs a self-collection campaign). Read More

    Safety and efficacy of current alternatives in the topical treatment of cutaneous leishmaniasis: a systematic review.
    Parasitology 2017 Apr 3:1-10. Epub 2017 Apr 3.
    Department of Clinical Analysis and Biomedicine,State University Maringa,Avenida Colombo, 5790, Jardim Universitário, CEP 87020-900, Maringá, Paraná,Brazil.
    Studies of topical treatments for leishmaniasis were systematically reviewed, to evaluate the therapeutic efficacy, safety and any adverse effects of these treatments. The papers identified in the databases PubMed and Web of Knowledge involved eight studies with a total of 1744 patients. The majority of trials was from Iran (4/8), covered a period of 8 years (2003-2011), and included patients 4-85 years of age. Read More

    A randomized clinical trial comparing cervical dysplasia treatment with cryotherapy vs loop electrosurgical excision procedure in HIV-seropositive women from Johannesburg, South Africa.
    Am J Obstet Gynecol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Internal Medicine, Clinical HIV Research Unit, Faculty of Health Science Center, University of Witwatersrand, Johannesburg, South Africa; Right to Care, Johannesburg, South Africa.
    Background: Mortality associated with cervical cancer is a public health concern for women, particularly in HIV-seropositive women in resource-limited countries. HIV-seropositive women are at a higher risk of high-grade cervical precancer, which can eventually progress to invasive carcinoma as compared to HIV-seronegative women. It is imperative to identify effective treatment methods for high-grade cervical precursors among HIV-seropositive women. Read More

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