Search Our Scientific Publications & Authors

Gastrointest Endosc Clin N Am 2018 Jul 12;28(3):307-320. Epub 2018 Apr 12.

Department of Visceral Surgery, Division of Endoscopy, Frankenwaldklinik, Kronach, Germany. Electronic address:

Despite major improvements in endoscopic devices and therapeutic endoscopy, rebleeding rates and mortality have remained the same for several decades. Therefore, much interest has been paid to emerging therapeutic devices, such as the over-the-scope clip and hemostatic sprays. Other emerging technologies, such as radiofrequency ablation, endoscopic suturing devices, and ultrasound-guided angiotherapy, are also being investigated to improve therapeutic outcomes in specific situations. Read More

Case Rep Dermatol 2018 May-Aug;10(2):127-132. Epub 2018 May 18.

Medical Department, Cantabria Lab, Difa Cooper, Caronno Pertusella, Italy.

Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. Read More

Tuberc Respir Dis (Seoul) 2018 Jun 19. Epub 2018 Jun 19.

Division of Respiratory and Critical Care Medicine, Korea University Guro Hospital, Seoul, Korea.

Background: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has not been well evaluated. We present our experiences of well-tolerated diagnostic bronchoscopy as well as cases of improved saturation in hypoxaemic patients after a therapeutic bronchoscopic procedure. Read More

J Natl Cancer Inst 2018 Feb;110(2):141-148

Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention.

Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Read More

J Hum Kinet 2018 Jun 13;62:55-63. Epub 2018 Jun 13.

Université de Franche Comté, Laboratoire C3S (EA 4660), Unité de Promotion, de Formation et de Recherche (UPFR) des Sports, 31 rue de l'Epitaphe, 25000, Besançon, France.

Partial-body cryostimulation is used to improve recovery after exercise, especially during competitions or heavy training; however, a limited number of studies have been conducted with international-level athletes in situ during competitions. This study was undertaken to assess the thermal sensation ratings during 3 min of cold exposure (at -130°C) in 24 international-level athletes during the European Basketball Championship. The mean thermal sensation score, measured using a perceptive scale, increased significantly (p < 0. Read More

J Vector Borne Dis 2018 Jan-Mar;55(1):42-46

Kerman Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background & Objectives: Leishmania parasites are sensitive to very low temperature. Cryotherapy is considered as an alternative to the existing pentavalent antimonials, for local treatment of cutaneous leishmaniasis (CL). Normally, liquid nitrogen (N) at a temperature of -196 °C, is used in cryotherapy of CL, but it's efficacy is not consistent. Read More

J Family Med Prim Care 2018 Jan-Feb;7(1):237-241

Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Wart is a common transferable skin disease that is caused by human papilloma virus. Choosing the best treatment method can vary based on age, therapeutic goal, complications, and wart place. Due to antibacterial effect of shallomin (hirtifolium Boiss extract) and since its effect has not been studied yet, it was compared to cryotherapy therapeutic methods for treating patients with plane warts. Read More

J Dermatol 2018 Jun 15. Epub 2018 Jun 15.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Granuloma faciale (GF) is a rare chronic dermatosis with still unknown etiopathology, which usually presents a solitary, asymptomatic, smooth reddish-brown to violaceous plaques or nodules on the face. Various therapeutic approaches, including topical application of corticosteroid or tacrolimus and removal with laser, cryotherapy and surgery have been attempted; however, the outcome has been inconsistent. Herein, we report a case of perinasal nodular GF who repeatedly underwent surgical excisions after the failure of laser treatment. Read More

Front Physiol 2018 30;9:659. Epub 2018 May 30.

Department of Sports Medicine and Human Nutrition, Faculty of Physical Education and Sport, University of Physical Education, Krakow, Poland.

Endurance runners may experience "sports anemia" resulting from intravascular hemolysis. In addition, aging has negative impact on hematopoiesis and rheological properties of blood, and erythrocyte membranes in older people are more vulnerable to oxidative damage, which together can lead to anemia. Whole-body cryostimulation (WBCST) is increasingly used in the elderly as a method of biological regeneration of athletes or therapy and preventive treatment. Read More

BMJ Open 2018 Jun 12;8(6):e020484. Epub 2018 Jun 12.

Department of Health Policy and Management, Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Background: Cervical cancer is the leading cause of cancer death for women in Uganda, despite the potential for prevention through organised screening. Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening.

Objective: Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of Reproductive Cancers (ASPIRE) trial, conducted in Kisenyi, Uganda in April 2014 (n=500). Read More

Actas Dermosifiliogr 2018 Jun 9. Epub 2018 Jun 9.

Servicio de Anatomía Patológica, Hospital Universitari Son Espases, Palma de Mallorca, Islas Baleares, España.

Ann Vasc Surg 2018 Jun 7. Epub 2018 Jun 7.

University of Miami.

The present report describes a case of cryotherapy ablation in a 35-year-old woman with a 1.5cm painful venous malformation in the right vastus lateralis muscle. After the patient had failed sclerotherapy, a single session of cryotherapy was performed that resulted in both technical and clinical success. Read More

J Vasc Interv Radiol 2018 Jul 5;29(7):1034-1040. Epub 2018 Jun 5.

Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan; Research Program for Diagnostic and Molecular Imaging, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, Japan.

Purpose: To employ bioluminescence imaging (BLI) as a quantitative imaging biomarker to assess preclinical evaluation of cryoablation in a murine model.

Materials And Methods: In vitro, Colon26-Luc (C26-Luc) cells were seeded at 6 different concentrations in 35-mm dishes. These were divided into 6 groups: group 0 (G0), a control group without treatment; and groups 1-5 (G1-G5) according to the number of freeze-thaw cycles, with each cycle consisting of freezing at -80°C for 10 min followed by thawing at room temperature for 5 minutes. Read More

J Stomatol Oral Maxillofac Surg 2018 Jun 5. Epub 2018 Jun 5.

Department of Oral and Maxillofacial Surgery, Nair Hospital Dental College, 400008 Mumbai Central, Mumbai. Electronic address:

The intramuscular haemangioma (IMH) is a rare variant of unknown aetiology and comprises 0.8% of soft tissue haemangiomas. Less than 20% of IMHs occur in the craniofacial region of which the masseter is the most common site. Read More

Am J Mens Health 2018 Jun 1:1557988318781731. Epub 2018 Jun 1.

1 Department of Clinical and Administrative Pharmacy, Division of Pharmaceutical Health Services, Outcomes, and Policy, College of Pharmacy, University of Georgia, Athens, GA, USA.

The high frequency of treatment-related side effects for men with localized prostate cancer creates uncertainty for treatment outcomes. This study assessed the comparative effectiveness of treatment-related side effects associated with conservative management and cryotherapy in patients with localized prostate cancer. A retrospective longitudinal cohort study was conducted, using the linked data of the Surveillance, Epidemiology, and End Results and Medicare, which included patients diagnosed from 2000 through year 2013, and their Medicare claims information from 2000 through 2014. Read More

Int J Womens Dermatol 2018 Jun 20;4(2):87-90. Epub 2017 Oct 20.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Cutaneous warts are caused by a small group of specific types of human papillomaviruses. Cryotherapy is a highly effective treatment for patients with viral warts; however, it is a painful method and usually requires several treatment sessions. Zinc is a trace element with many proven effects on the immune system. Read More

J Am Acad Dermatol 2018 Jun 1. Epub 2018 Jun 1.

Department of Family Medicine and Primary Care, The University of Hong Kong and Queen Mary Hospital, Pokfulam, Hong Kong.

Yakugaku Zasshi 2018 ;138(6):767-772

School of Pharmacy, Iwate Medical University.

　Cancer chemotherapy-induced stomatitis may spread throughout a patient's entire oral cavity and decrease the patient's QOL. The therapy for stomatitis at Iwate Medical University Hospital (IMUH) includes dental treatment before chemotherapy, in addition to oral rinses or cryotherapy as a preventative measure. However, in our survey of doctors and nurses, the responses of patients "satisfied" with the present approach for stomatitis treatment reached only 5. Read More

Complement Ther Med 2018 Jun 24;38:92-93. Epub 2018 Apr 24.

Physical Medicine and Rehabilitation Department, Sébastopol Hospital, University of Reims Champagne-Ardenne, France.

J Obes 2018 2;2018:5789647. Epub 2018 May 2.

Division of Infection and Pathway Medicine, University of Edinburgh, Little France, Edinburgh, UK.

Background: Local adipose tissue (AT) cooling is used to manage obesity and overweight, but the mechanism is unclear. The current view is that acute local cooling of AT induces adipocyte cell disruption and inflammation ("cryolipolysis") that lead to adipocyte cell death, with loss of subcutaneous fat being recorded over a prolonged period of weeks/months. A contrasting view is that AT loss via targeted cryotherapy might be mediated by thermogenic fat metabolism without cell disruption. Read More

Oxid Med Cell Longev 2018 2;2018:7365490. Epub 2018 May 2.

Department of Internal Medicine, Angiology and Physical Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.

Objective: The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS).

Material And Methods: The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in male AS patients (WBC group = 16) was investigated. To assess the disease activity, the Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were calculated. Read More

Cochrane Database Syst Rev 2018 05 30;5:CD005010. Epub 2018 May 30.

Department of Urology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon, Korea, South, 26426.

Background: Traditionally, radical prostatectomy and radiotherapy with or without androgen deprivation therapy have been the main treatment options to attempt to cure men with localised or locally advanced prostate cancer. Cryotherapy is an alternative option for treatment of prostate cancer that involves freezing of the whole prostate (whole gland therapy) or only the cancer (focal therapy), but it is unclear how effective this is in comparison to other treatments.

Objectives: To assess the effects of cryotherapy (whole gland or focal) compared with other interventions for primary treatment of clinically localised (cT1-T2) or locally-advanced (cT3) non-metastatic prostate cancer. Read More

J Sport Rehabil 2018 May 29:1-20. Epub 2018 May 29.

a North Dakota State University, Fargo, ND.

Context: Allied health care professionals commonly apply cryotherapy as treatment for acute musculoskeletal trauma and the associated symptoms. Understanding the impact of a tape barrier on intramuscular temperature can assist in determining treatment duration for effective cryotherapy.

Objective: To determine whether Kinesio® Tape acts as a barrier that affects intramuscular temperature during cryotherapy application. Read More

Int J Sports Physiol Perform 2018 May 29:1-23. Epub 2018 May 29.

5 Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle, United Kingdom.

Purpose: The purpose of this study was to assess the utility of an inertial sensor for assessing recovery in professional soccer players.

Methods: In a randomized, crossover design, 11 professional soccer players wore shorts fitted with phase change material (PCM) cooling packs or uncooled packs (control) for 3 h after a 90 minute match. Countermovement jump (CMJ) performance was assessed simultaneously with an inertial sensor and an optoelectric system, pre match, and 12, 36 and 60 h post match. Read More

BMC Health Serv Res 2018 May 25;18(1):378. Epub 2018 May 25.

Duke Global Health Institute, Duke University, Durham, NC, USA.

Background: Cervical cancer is the most frequent neoplasm among Kenyan women, with 4800 diagnoses and 2400 deaths per year. One reason is an extremely low rate of screening through pap smears, at 13.8% in 2014. Read More

Urology 2018 May 22. Epub 2018 May 22.

USC Institute of Urology and The Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objective: To describe our management strategy for rectourethral fistula (RUF) after focal treatment for prostate cancer (PCa) using 2 cases as an example. Almost 50% of RUFs are associated with energy treatment modalities for PCa. The adjacent damage to healthy tissue along with limited pliability of it makes the success of the repair troublesome. Read More

Dermatol Surg 2018 Jun;44(6):848-854

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Current approaches use subjective semiquantitative or cumbersome objective methodologies to assess physical characteristics of hypertrophic and keloid scars.

Objective: This pilot study aimed to evaluate the accuracy and feasibility of a new stereoscopic optical and high-resolution 3-dimensional imaging system, for objectively measuring changes in above-surface scar volume after various interventions.

Methods: Feasibility and accuracy were assessed by monitoring the above-surface scar volume of 5 scars in 2 patients for 5 successive months. Read More

Scars Burn Heal 2017 Jan-Dec;3:2059513117702162. Epub 2017 Apr 17.

School of Medicine, Queen Mary University London, UK.

Introduction: Hypertrophic and keloid scarring remain notoriously troublesome for patients to tolerate and frustratingly difficult for clinicians to treat. Many different treatment modalities exist, signifying the failure of any method to achieve consistently excellent results. Intralesional cryotherapy is a relatively recent development that uses a double lumen needle, placed through the core of a keloid or hypertrophic scar, to deliver nitrogen vapour, which freezes the scar from its core, outwards. Read More

J Dermatolog Treat 2018 May 23:1-10. Epub 2018 May 23.

a Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Science , Tehran , Iran.

Background: Cryotherapy using Wartner compound that contains a mixture of dimethyl ether (75%) and propane (25%) has been recently reported as an effective treatment for warts. The present study aimed to evaluate the safety and efficacy of Wartner in male patients with genital warts.

Methods: A Phase II parallel-randomized clinical trial was performed on 16 Iranian men affected by genital warts who were referred to a dermatology clinic at Tehran University of Medical Sciences. Read More

Ophthalmologe 2018 Jun;115(6):456-463

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstraße 5, 79106, Freiburg, Deutschland.

Background: The treatment of retinopathy of prematurity (ROP) has gained a new dynamic since the introduction of anti-vascular endothelial growth factor (VEGF) therapy. This review summarizes clinical trial data in order to aid informed decision-making.

Methods: In this article, pivotal clinical trials are summarized and discussed with regard to their implications for ROP therapy. Read More

J Thorac Dis 2018 Apr;10(Suppl 10):S1163-S1167

Thoracic Department, Curie-Montsouris Thorax Institute-Institut Mutualiste Montsouris, Paris, France.

The expanded possibilities to explore the lung deeper with new tools such as electromagnetic navigation bronchoscopy (ENB) or radial probe endobronchial ultrasonography (radial EBUS), combined with miniaturization of traditional local therapies such as radiofrequency ablation (RFA), radiotherapy, cryotherapy or photodynamic therapy, let the bronchoscopists hope for new ways of endoscopic treatments. This challenge could change the practice in the upcoming decades but raise some physical and technical issues. Safety and efficacy need to be solidly established to face the serious concurrence of stereotactic radiotherapy (SBRT) or percutaneous RFA. Read More

Acta Dermatovenerol Croat 2018 Apr;26(1):68-70

Daniela Ledić Drvar, MD, PhD, University Hospital Centre Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients. PK occurs worldwide, with the incidence rates varying based on the environment and occupation. Read More

Acta Dermatovenerol Croat 2018 Apr;26(1):64-67

Elena-Daniela Serban, MD, Department of Medical Oncology, University of Bologna, 40138 Bologna; Italy.

Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. Read More

Ann Dermatol Venereol 2018 May 17. Epub 2018 May 17.

Service de dermatologie, hôpital militaire Moulay Ismail, 50000 Meknès, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohammed Ben Abdellah USMBA, 30000 Fès, Maroc.

Background: Chromomycosis is a chronic fungal skin infection, mainly affecting the limbs. It is responsible for severe morbidity and its treatment remains long and disappointing. Rarely described in Morocco, we report a new observation that has evolved very well under treatment combining terbinafine and cryotherapy over a short duration. Read More

Br J Dermatol 2018 May 19. Epub 2018 May 19.

Department of Dermatology, Bichat Claude Bernard Hospital AP-HP, Paris, France.

Human papillomavirus (HPV) infection has been a subject of interest for decades, notably because of the high burden of HPV-related diseases . High-risk HPVs (HR-HPV) are responsible for virtually all cases of cervical cancer and are also implicated in other mucosal cancers especially those located in the anal and oropharyngeal areas. Low-risk HPVs (LR-HPV) can induce cutaneous or anogenital warts, usually treated with cryotherapy, CO laser vaporization, topical application of salicylic acid or imiquimod. Read More

Dig Dis Sci 2018 May 17. Epub 2018 May 17.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First Ave., SW, Rochester, MN, 55905, USA.

The management of Barrett's esophagus and early esophageal adenocarcinoma has shifted away from esophagectomy and toward endoscopic techniques, including endoscopic resection and ablative therapies. The most commonly used ablative therapies are radiofrequency ablation and cryotherapy. Radiofrequency ablation has risen to the top of the management algorithm due to its favorable safety profile and established track record of efficacy in patients with dysplastic Barrett's. Read More

Ann Otol Rhinol Laryngol 2018 Jun;127(6):395-401

1 Department of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Objective: Summarize the effectiveness of intraoperative cryoanalgesia in the management of postoperative pain among patients undergoing palatine tonsillectomy.

Methods: A systematic review of PubMED, MEDLINE, EMBASE, Google Scholar, and Cochrane trial registries was performed through January 2017 using the PRISMA standards. We included English-language randomized controlled trials evaluating patients of all age groups with benign pathology who underwent tonsillectomy with cryoanalgesia versus without. Read More

J Gynecol Oncol 2018 Jul 20;29(4):e55. Epub 2018 Mar 20.

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Objective: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements.

Methods: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model. Read More

Gland Surg 2018 Apr;7(2):166-187

Center for Interventional Oncology, National Cancer Institute, Bethesda, MD, USA.

Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy. Read More

J Sports Sci Med 2018 Jun 14;17(2):322-329. Epub 2018 May 14.

Faculty of Physical Education and Physiotherapy, Human Physiology Research Group, Vrije Universiteit Brussel, Brussels, Belgium.

Cryotherapy is widely used in sports and rehabilitation to aid recovery and injury management. The purpose was to examine if a low temperature computer controlled continuous knee cooling protocol (10°C) for one hour and a moderate continuous knee cooling protocol (18°C) for one hour affected neuromuscular activity and functional performance tests. We used a randomized controlled study design. Read More

Ocul Oncol Pathol 2018 Apr 20;4(3):152-156. Epub 2017 Oct 20.

The Ohio State University Department of Ophthalmology, Columbus, OH, USA.

Background/aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology.

Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months. Read More

Int J Obstet Anesth 2018 Apr 10. Epub 2018 Apr 10.

Department of Anesthesiology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Flexible bronchoscopy, therapeutic bronchoscopy and other procedures requiring anesthesia are generally avoided in pregnancy and postponed until after delivery if possible. We report a case of a parturient with an abnormal chest radiograph and mild obstructive symptoms of unknown etiology. At bronchoscopy, a tumor associated with post-obstructive suppuration was found and excised using electrocautery snare and cryotherapy, for restoration of airway patency. Read More

Gastrointest Endosc 2018 06;87(6):1594-1595

CSA Medical, Inc., Lexington, Massachusetts, USA.

Front Physiol 2018 26;9:403. Epub 2018 Apr 26.

Laboratoire MOVE (EA6314), Faculty of Sport Sciences, University of Poitiers, Poitiers, France.

The aim of the present work was to perform a meta-analysis evaluating the impact of recovery techniques on delayed onset muscle soreness (DOMS), perceived fatigue, muscle damage, and inflammatory markers after physical exercise. Three databases including , and were searched using the following terms: ("recovery" or "active recovery" or "cooling" or "massage" or "compression garment" or "electrostimulation" or "stretching" or "immersion" or "cryotherapy") and ("DOMS" or "perceived fatigue" or "CK" or "CRP" or "IL-6") and ("after exercise" or "post-exercise") for randomized controlled trials, crossover trials, and repeated-measure studies. Overall, 99 studies were included. Read More

Gastrointest Endosc 2018 May 8. Epub 2018 May 8.

Cancer Treatment Centers of America(®), 5900 Broken Sound Parkway, Boca Raton, FL 33487, USA.

Background And Aims: Dysphagia is a debilitating symptom in patients with inoperable esophageal cancer contributing to poor quality of life and worsening nutritional status. The 2 most commonly used palliative modalities for dysphagia are radiation therapy (RT) and esophageal stent placement. However, RT is limited by adverse events (AEs) and total dose, and stent placement has a high rate of AEs including reflux, migration, and chest pain. Read More

Investig Clin Urol 2018 May 20;59(3):152-157. Epub 2018 Mar 20.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To describe the salvage radical prostatectomy (sRP) experience in patients presenting with recurrent, clinically localized prostate cancer after multiple failed local treatments.

Materials And Methods: Among the 251 sRP performed during 2000-2016, 11 patients had failed multiple local therapies. We describe baseline clinical characteristics at primary cancer diagnosis and prior to sRP, surgical information, complications and oncological outcomes. Read More

Prostate Cancer Prostatic Dis 2018 May 9. Epub 2018 May 9.

Department of Urology, Institut Montsouris, Paris, France.

Background: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics. Our intention was to review the literature for special aspects of the different technologies that might be of advantage depending on individual patient and tumour characteristics. Read More

J Hand Surg Asian Pac Vol 2018 Jun;23(2):278-281

* Department of Plastic Surgery, Carmel Lady Davis Medical Center, Israel.

Infantile Digital Fibromatosis (IDF) is a rare benign lesion that can affect the fingers, often appearing at birth or early on in life. Treatment is controversial due to a high recurrence rate following surgical excision, and the tendency of the lesions to regress or resolve completely after the age of one year. Functional loss has rarely been described. Read More

Cryo Letters 2018 Mar/Apr;39(2):137-146

Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha, India.

Background: Cryogen spray cooling is an effective method to treat nodular basal cell carcinoma.

Objective: To study the effect of spraying distance (z = 27 mm, 18 mm and 9 mm) on a nodular gel phantom and to validate the numerical model.

Materials And Methods: Liquid nitrogen is sprayed on agarose gel phantom using 0. Read More

Cryo Letters 2017 Sep/Oct;38(5):379-386

Potiguar University, Department of physiotherapy, Natal, Brazil.

　　BACKGROUND: The cryolipolysis is on the spotlight as a non-invasive method which reduces fat layer thickness with no damage to surrounding tissues.

Objective: This study aims to verify the effectiveness of cryolipolysis in the reduction of localized adiposity in women.

Materials And Methods: This is an experimental study, without a control group, with pre- and post- treatment evaluation through a single application on the lower abdominal area. Read More