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    1 OF 562

    Whole-body Cryotherapy as a Recovery Technique after Exercise: A Review of the Literature.
    Int J Sports Med 2017 Nov 21. Epub 2017 Nov 21.
    Faculty of Health Sciences, University of Sydney, Sydney, Australia.
    This review aims to evaluate the current body of literature investigating the effect of whole body cryotherapy on recovery after exercise. A systematic search was conducted to investigate the effect of whole body cryotherapy (WBC, exposure to temperatures between -110 to -190°C) on markers of recovery after damaging exercise in healthy, physically active subjects. Of the 16 eligible articles extracted, ten induced muscle damage using controlled exercise in a laboratory setting, while six induced damage during sport-specific training. Read More

    Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review.
    Urol Int 2017 Nov 21. Epub 2017 Nov 21.
    How to manage patients with prostate cancer (PCa) with biochemical recurrence (BCR) following primary curative treatment is a controversial issue. Importantly, this prostate-specific antigen (PSA)-only recurrence is a surrogate neither of PCa-specific survival nor of overall survival. Physicians are therefore challenged with preventing or delaying the onset of clinical progression in those deemed at risk, while avoiding over-treating patients whose disease may never progress beyond PSA-only recurrence. Read More

    Impact of upper body precooling during warm-up on subsequent time trial paced cycling in the heat.
    J Sci Med Sport 2017 Oct 16. Epub 2017 Oct 16.
    The University of Alabama, United States.
    Objectives: The purpose of this study was to test the hypothesis that cooling the upper body during a warm-up enhances performance during a subsequent 16.1-km simulated cycling time trial in a hot environment.

    Design: Counterbalanced, repeated measures design. Read More

    Salvage Low Dose Rate Brachytherapy For Recurrent Prostate Cancer After External Beam Radiotherapy: Results From A Single Institution With Focus On Toxicity And Functional Outcomes.
    Clin Med Insights Oncol 2017 7;11:1179554917738765. Epub 2017 Nov 7.
    Radiation Oncology Department, University and Spedali Civili Hospital, Brescia, Italy.
    Background/aim: Low dose rate brachytherapy has been used as salvage therapy for locally recurrent prostate cancer (PC) after primary external beam radiation therapy (EBRT), along with surgery and cryotherapy. All these techniques, in particular, when applied to the whole gland, involve a relatively high risk of toxicity and may worsen the patient's quality of life. Our aim is to evaluate the results of whole-gland salvage brachytherapy (SBT) after primary EBRT in terms of toxicity, functional outcomes, and efficacy. Read More

    PSA kinetics following primary focal cryotherapy (hemiablation) in organ-confined prostate cancer patients.
    World J Urol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Urology, NYU-Winthrop Hospital, 1300 Franklin Ave, Garden City, Mineola, NY, 11530, USA.
    Purpose: We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients.

    Materials And Methods: This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Read More

    [Effect of different tourniquet releasing strategy on blood loss in total knee arthroplasty].
    Zhonghua Yi Xue Za Zhi 2017 Nov;97(41):3219-3224
    Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China.
    Objective: To explore the influences on peri-operative blood loss and postoperative blood transfusion in primary total knee arthroplasty when using different methods to release the pneumatic tourniquet. Methods: From January 2015 to December 2016, 484 patients with osteoarthritis were enrolled, undergoing primary unilateral total knee arthroplasty in the Orthopedics Department of Peking University Third Hospital. Retrospective data was used, and all the patients had been operated on by three independent working groups. Read More

    Managing Seborrheic Keratoses: Evolving Strategies for Optimizing Patient Outcomes.
    J Drugs Dermatol 2017 Nov;16(11):1064-1068

    The seborrheic keratosis is the most common benign skin tumor of middle-aged and elderly adults, affecting nearly 83 million individuals in the US alone. Although these are benign lesions, many patients still undergo some form of treatment. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so. Read More


    Cold-water or partial-body cryotherapy? Comparison of physiological responses and recovery following muscle damage.
    Scand J Med Sci Sports 2017 Nov 11. Epub 2017 Nov 11.
    Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Landquart, Switzerland.
    The aim of this study was to compare i) the physiological responses following cold-water immersion (CWI) and partial-body cryotherapy (PBC) and ii) the effects on recovery following a muscle-damaging protocol (5 x 20 drop jumps). Nineteen healthy males were randomly allocated into either a CWI (10 °C for 10 min; n = 9) or a PBC (-60 °C for 30 sec, -135 °C for 2 min; n = 10) group. The physiological variables (thigh muscle oxygen saturation [SmO2 ], cutaneous vascular conductance [CVC], mean-arterial pressure [MAP] and local skin temperature) were assessed immediately prior and up to 60 min post-treatment (10 min intervals). Read More

    Endometrial ablation.
    Best Pract Res Clin Obstet Gynaecol 2017 Oct 20. Epub 2017 Oct 20.
    Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Director of Gynecologic Services, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, CA, United States. Electronic address:
    Endometrial ablation (EA) includes a spectrum of procedures performed with or without hysteroscopic direction, designed to destroy the endometrium for the treatment of the symptom of heavy menstrual bleeding (HMB) secondary to a spectrum of causes, but most commonly those that are endometrial in origin (AUB-E) or ovulatory disorders (AUB-O). Resectoscopic endometrial ablation (REA) is often mistakenly referred to as the "first generation" technique, while proprietary devices that do not use the resectoscope (nonresectoscopic EA or NREA) are often misperceived as "second generation" devices. Indeed, the origins of NREA date back to the late 19th century with the use of steam, and the early and mid 20th century, when radiofrequency and cryotherapy based NREA techniques were published - long before the resectoscope was used and reported. Read More

    Recovery following a marathon: a comparison of cold water immersion, whole body cryotherapy and a placebo control.
    Eur J Appl Physiol 2017 Nov 10. Epub 2017 Nov 10.
    London Sports Institute, Middlesex University, Allianz Park, Greenlands Lane, London, NW4 1RL, UK.
    Purpose: Cryotherapy is an increasingly popular recovery strategy used in an attempt to attenuate the negative impact of strenuous physical activity on subsequent exercise. Therefore, this study aimed to assess the effects of whole body cryotherapy (WBC) and cold water immersion (CWI) on markers of recovery following a marathon.

    Methods: Thirty-one endurance trained males completed a marathon. Read More

    Malignant melanoma presenting as amelanotic caruncular lesion in a child.
    J AAPOS 2017 Nov 7. Epub 2017 Nov 7.
    Department of Ophthalmology.
    Conjunctival melanoma is a relatively rare malignant neoplasm that can present in childhood in any part of the conjunctiva. The infrequency with which conjunctival melanoma is encountered in childhood caruncular lesions makes it a formidable but important aspect of the differential diagnosis. We report the case of a 10-year-old boy who presented with a left caruncular lesion. Read More

    Prospective Outcome Analysis of the Safety and Efficacy of Partial and Complete Cryoablation in Organ-Confined Prostate Cancer.
    Urology 2017 Nov 7. Epub 2017 Nov 7.
    Division of Urology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, Colorado.
    Objectives: To determine the rate of complications and change in IPSS and SHIM scores following cryotherapy treatment of low and intermediate risk prostate cancer. Secondary endpoint was change in PSA post-cryotherapy and biopsy-proven recurrence.

    Methods: Enrollment occurred from 2007-2015 to assess long-term complications of cryotherapy. Read More

    [Keratoacanthomas on recent tattoos: Two cases].
    Ann Dermatol Venereol 2017 Nov 7. Epub 2017 Nov 7.
    Consultation « tatouage », service de dermatologie, hôpital Bichat - Claude-Bernard, hôpitaux universitaires Paris-Nord-Val-de-Seine, 46, rue Henri-Huchard, 75018 Paris, France.
    Background: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context. Read More

    [Salvage prostate brachytherapy: A solution for local failures after a primary radiation therapy?]
    Cancer Radiother 2017 Nov 6. Epub 2017 Nov 6.
    Centre Georges-François-Leclerc, rue du Professeur-Marion, 21000 Dijon, France.
    Salvage brachytherapy after a first prostate radiation therapy is an emerging technique, which has to be considered in the therapeutic armamentarium in the clinically challenging context of patients with isolated local failure from prostate cancer who may still be considered for cure. These occult failures are more and more frequently diagnosed at an early stage, thanks to targeted biopsies and advances in imaging modalities, such as multiparametric MRI and PET-CT. Salvage brachytherapy benefits from the implantation accuracy of brachytherapy procedures using 3D dosimetry and has resulted in more than 50% tumour control rates with long-term. Read More

    Retinopathy of prematurity like retinopathy in full-term infants.
    Oman J Ophthalmol 2017 Sep-Dec;10(3):167-172
    Vitreo-Retinal Consultant, C.L. Gupta Eye Institute, Moradabad, Uttar Pradesh, India.
    Purpose: The purpose of this study is to assess clinical characteristics, risk factors, and management outcomes of retinal changes similar to retinopathy of prematurity (ROP), seen in full-term infants.

    Patients And Methods: This is a retrospective review of 46 eyes of 23 patients, born at full term or near full term and diagnosed to have active ROP-like retinopathy or sequelae of ROP-like retinopathy.

    Results: Mean birth weight (BW) and gestational age (GA) were 2342 ± 923 g (range, 1200-4160 g) and 38. Read More

    Hypothermia Promotes Cell-Protective and Chondroprotective Effects After Blunt Cartilage Trauma.
    Am J Sports Med 2017 Nov 1:363546517736051. Epub 2017 Nov 1.
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany.
    Background: Cryotherapy is routinely administered after sports injuries of synovial joints. Although positive clinical effects on periarticular swelling and pain have been described, the effects on the cell biological activities of cartilage and synovial cells remain largely unknown so far.

    Hypothesis: Local hypothermia alleviates synovial reactions and prevents chondrocyte death as well as cartilage destructive processes after blunt cartilage trauma. Read More

    Intravitreal bevacizumab for neovascular glaucoma in uveal melanoma treated by proton beam therapy.
    Graefes Arch Clin Exp Ophthalmol 2017 Nov 7. Epub 2017 Nov 7.
    Ophthalmology Department, Institut Curie, Paris, France.
    Background: To evaluate the efficacy of bevacizumab on reduction of the enucleation rate and control of intraocular pressure (IOP) in neovascular glaucoma (NVG)-complicating proton beam therapy for UM and to identify the determinants of the efficacy of bevacizumab.

    Methods: Retrospective comparative study of patients with rubeosis following proton therapy for uveal melanoma. Patients were divided into two groups: a bevacizumab group and a control group which comprised two subgroups: panretinal photocoagulation (PRP)/cryotherapy and observation subgroups. Read More

    Oncologic Outcomes of Definitive Treatments for Low- and Intermediate-Risk Prostate Cancer After a Period of Active Surveillance.
    Clin Genitourin Cancer 2017 Oct 16. Epub 2017 Oct 16.
    Department of Urology, Columbia University Medical Center, New York, NY.
    Background: To compare oncologic outcomes of different definitive treatment (DT) modalities in a cohort of patients with prostate cancer (PCa) after active surveillance (AS).

    Methods: We identified 237 patients with National Comprehensive Cancer Network (NCCN) low- and intermediate-risk prostate cancer diagnosed from 1990 to 2012 who did not undergo immediate DT within 12 months of diagnosis (ie, AS patients as well as watchful waiting and those refusing DT). Charts were examined for clinical/pathologic data and type of DT: surgery (RP), radiation including brachytherapy (XRT), cryotherapy, and androgen deprivation therapy monotherapy (ADT). Read More

    Focal Ablation of Early-Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome.
    Urol Clin North Am 2017 Nov;44(4):575-585
    Division of Surgery, Department of Surgery and Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK; Imperial Urology, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.
    Prostate cancer lesions smaller than 0.5 m(3), or Gleason pattern 3, are likely clinically insignificant. Clinically significant disease is often limited to a single index lesion. Read More

    Cryotherapy to treat and prevent airway stenosis in a patient with granulomatosis with polyangiitis.
    Pediatr Pulmonol 2017 Nov 3. Epub 2017 Nov 3.
    Icahn School of Medicine at Mount Sinai, Departments of Pediatrics (Kravis Children's Hospital), New York, New York.
    We report our use of cryotherapy delivered via flexible bronchoscopy in a 15-year old girl with granulomatosis with polyangiitis to both treat established airway stenosis and prevent multi-level progression of disease. Read More

    Does Surgical Fragmentation of Odontogenic Keratocystic Capsule Interfere With the Recurrence Rate?
    J Oral Maxillofac Surg 2017 Oct 13. Epub 2017 Oct 13.
    Professor, Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:
    Purpose: We hypothesized that fragmentation of the cystic capsule during surgery would influence the recurrence rate of odontogenic keratocysts (OKCs) regardless of the treatment modality chosen.

    Materials And Methods: We reviewed, in a retrospective study, cases diagnosed as OKCs on histopathologic examination at the oral pathology department between 1991 and 2013. Fragmentation data were obtained from the records of the oral surgical department. Read More

    Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy.
    JAMA Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Ophthalmology, Jules-Gonin Eye Hospital, Lausanne, Switzerland.
    Importance: The risk of extraocular extension from injecting chemotherapy into eyes with retinoblastoma is minimally understood; however, understanding this risk is important because of the increasing use of intravitreous chemotherapy.

    Objective: To evaluate the risk of extraocular extension in eyes with retinoblastoma that have received intravitreous chemotherapy injections.

    Design, Setting, And Participants: This retrospective cohort study was performed in 655 patients at 10 retinoblastoma centers in North and South American, European, Israeli, and Chinese centers. Read More

    Relevance of urinary S100B protein levels as a short-term prognostic biomarker in asphyxiated infants treated with hypothermia.
    Medicine (Baltimore) 2017 Nov;96(44):e8453
    Neonatal Unit, Department of Pediatrics, Santiago de Compostela University Hospital, IDIS (Health Research Institute of Santiago de Compostela), CIBERER, Travesia Choupana, Santiago de Compostela, Spain.
    The initial diagnosis of neonatal hypoxic-ischemic encephalopathy is based on nervous system clinical manifestations. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects allows early intervention and treatment. This study was designed to determine the short-term prognostic significance of urinary S100B calcium-binding protein (S100B) in asphyxiated newborns treated with hypothermia. Read More

    Secondary Prevention of Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline.
    J Glob Oncol 2017 Oct 12;3(5):635-657. Epub 2016 Oct 12.
    , PATH, Seattle, WA; , Global Coalition Against Cervical Cancer, Albert Einstein College of Medicine, Arlington; , American Society of Clinical Oncology, Alexandria, VA; , University of Cape Town, Cape Town, South Africa; , V Care; , Tata Memorial Center, Mumbai, India; , Harvard T.H. Chan School of Public Health, Boston, MA; , PanAmerican Health Organization, Washington, DC; , Uganda Women's Health Initiative, Kampala, Uganda; , International Network for Cancer Treatment and Research, Dar Es Salaam, Tanzania; , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; , University of Melbourne, Melbourne, Victoria, Australia; , International Agency for Research on Cancer, Lyon, France; , Queen Mary, University of London, London, United Kingdom; and , The University of Texas MD Anderson Cancer Center, Houston, TX.
    Purpose: To provide resource-stratified, evidence-based recommendations on the secondary prevention of cervical cancer globally.

    Methods: ASCO convened a multidisciplinary, multinational panel of oncology, primary care, epidemiology, health economic, cancer control, public health, and patient advocacy experts to produce recommendations reflecting four resource-tiered settings. A review of existing guidelines, a formal consensus-based process, and a modified ADAPTE process to adapt existing guidelines were conducted. Read More

    Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases.
    Int J Dermatol 2017 Oct 31. Epub 2017 Oct 31.
    Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
    Background: Epidermolytic acanthoma (EA) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple EAs) are rarely reported.

    Methods: We retrospectively identified patients diagnosed with multiple EAs between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. Read More

    Assessment of retinoblastoma RNA reflux after intravitreal injection of melphalan.
    Br J Ophthalmol 2017 Oct 31. Epub 2017 Oct 31.
    Unit of Clinical Pharmacokinetics, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.
    Background: Intravitreal injection of chemotherapy in retinoblastoma eyes with vitreous seeds may lead to a risk of extraocular tumour dissemination that has not been assessed so far.

    Aims: To develop a sensitive and clinically feasible technique to assess for potential retinoblastoma cell reflux after intravitreal injection of melphalan.

    Methods: Filter papers were cut in 6 mm diameter circles and sterilised before use. Read More

    Effectiveness of Proprioceptive Neuromuscular Facilitation (PNF) in Improving Shoulder Range of Motion. A Pilot Study.
    Ortop Traumatol Rehabil 2017 May;19(3):285-292
    Division of Clinical Rehabilitation, Medical University of Warsaw, Lekmed Clinic in Warsaw, Poland.
    [b]Background.[/b] Subacromial impingement syndrome is a condition of the shoulder girdle which limits daily activities. It is worth seeking fast and effective treatment options. Read More

    Microwave therapy for cutaneous human papilloma virus infection.
    Eur J Dermatol 2017 Oct;27(5):511-518
    Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, UK, Department of Dermatology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.
    Background: Human papilloma virus (HPV) infects keratinocytes of the skin and mucous membranes, and is associated with the induction of cutaneous warts and malignancy. Warts can induce significant morbidity and disability but most therapies, including cryotherapy, laser, and radiofrequency devices show low efficacy and induce discomfort through tissue destruction. Microwaves are readily capable of passing through highly keratinised skin to deliver energy and induce heating of the tissue in a highly controllable, uniform manner. Read More

    Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial.
    Dermatol Ther 2017 Oct 30. Epub 2017 Oct 30.
    Center for Research & Training in Skin Disease & Leprosy, Tehran University of Medical Science, Tehran, Iran.
    The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 skin warts. Read More

    Postoperative continuous-flow cryocompression therapy in the acute recovery phase of hip fracture surgery-A randomized controlled clinical trial.
    Injury 2017 Oct 10. Epub 2017 Oct 10.
    Department of Orthopaedics, Spaarne Gasthuis, Hoofddorp, The Netherlands.
    Background: The acute recovery phase after hip fracture surgery is often complicated by severe pain, postoperative blood loss with subsequent transfusion, and delirium. Prevalent comorbidity in hip fracture patients limit the use of opioid-based analgesic therapies, yielding a high risk for inferior pain treatment. Postoperative cryotherapy is suggested to provide an analgesic effect, and to reduce postoperative blood loss. Read More

    Intracanal Cryotherapy Reduces Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Multicenter Clinical Trial.
    J Endod 2017 Oct 24. Epub 2017 Oct 24.
    Department of Conservative Dentistry, School of Dentistry, Complutense University, Madrid, Spain.
    Introduction: A prospective, multicentered, randomized clinical trial was designed to assess if controlled irrigation with cold saline could result in less incidence and intensity of postoperative pain in patients presenting with pulp necrosis and symptomatic apical periodontitis.

    Methods: A total of 210 patients (presenting with necrotic uniradicular teeth with a diagnosis of symptomatic apical periodontitis and a preoperative visual analog scale (VAS) score higher than 7) were randomly allocated in the control or experimental group after the completion of shaping and cleaning procedures. The experimental group received a final irrigation with 20 mL sterile cold (2. Read More

    Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.
    JAMA 2017 10;318(16):1550-1560
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
    Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours.

    Objective: To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy. Read More

    Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis.
    Am J Otolaryngol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Otorhinolaryngology, head and neck surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
    Background: Nasal Polyposis is a benign tumor in nasal or paranasal mucosa, which confronts difficulties in management of healing after treatments with surgery. The aim of this study was to evaluate the effects of Spray Cryotherapy (SCT) on management of healing in patients with nasal polyposis who undergone functional endoscopic sinus surgery.

    Methods: In this prospective, clinical trial study, we investigated on 40 patients with nasal polyposis that had indication for functional endoscopic sinus surgery. Read More

    Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia.
    Indian J Ophthalmol 2017 Oct;65(10):936-941
    Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Purpose: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN).

    Methods: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year.

    Results: The median age of presentation was 55 years with male:female ratio being 4. Read More

    Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection.
    Pak J Pharm Sci 2017 Jul;30(4(Suppl.)):1505-1508
    Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment. Read More

    Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis.
    Cornea 2017 Oct 13. Epub 2017 Oct 13.
    CJ Shah Cornea Services, Dr. G. Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
    Purpose: To report outcomes of mucous membrane grafting (MMG) for refractory giant papillae in vernal keratoconjunctivitis.

    Methods: Eleven eyes of 6 patients having giant papillae and recurrent shield ulcers refractory to topical medications, cryotherapy, and supratarsal steroid injections and shave excision of papillae underwent surgical resection of the giant papillae with MMG. Average occurrence of shield ulcers was twice per eye per year before the procedure with 50% of eyes having steroid-induced cataract and glaucoma. Read More

    Effectiveness of Salted Ice Bag Versus Cryo-Compression on Decreasing Intramuscular and Skin Temperature.
    J Sport Rehabil 2017 Oct 16:1-22. Epub 2017 Oct 16.
    1 Sports Medicine & Rehabilitation, Moravian College, Bethlehem, PA.
    Context: Rest, ice, compression, and elevation are commonly recommended immediately post-injury. Traditionally, ice bag with elastic wrap compression has been utilized, however recently intermittent cryo-compression units are being used. Limited research has evaluated tissue temperature decreases with intermittent cryo-compression units. Read More

    Transient global amnesia following a whole-body cryotherapy session.
    BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.
    Spitalzentrum Biel AG, Biel, Switzerland.
    Whole-body cryotherapy (WBC), which consists of a short exposure to very cold and dry air in special 'cryo-chambers', is believed to reduce inflammation and musculoskeletal pain as well as improve athletes' recovery. This is the case of a 63-year-old male, who presented with transient global amnesia (TGA) after undertaking a WBC session. TGA is a clinical syndrome characterised by a sudden onset of anterograde amnesia, sometimes coupled with a retrograde component, lasting up to 24 hours without other neurological deficits. Read More

    Pre-emptive ice cube cryotherapy for reducing pain from local anaesthetic injections for simple lacerations: a randomised controlled trial.
    Emerg Med J 2017 Oct 12. Epub 2017 Oct 12.
    Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
    Objective: Subcutaneous local anaesthetic injection can be painful to patients in the ED. We evaluated the effect of cryotherapy by application of an ice cube to the injection site prior to injection in patients with simple lacerations.

    Methods: We conducted a prospective, randomised, controlled trial in consented patients with simple lacerations needing primary repair at a single emergency centre from April to July 2016. Read More

    Intralesional excision with topical intralesional cryotherapy improves the treatment of keloid scarring in a paediatric patient.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e233-e335. Epub 2017 Sep 15.
    Department of Plastic Surgery, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust , London , UK.
    Recurrent keloid scarring has a significant impact on quality of life. Management is complex, particularly for scars resistant to conventional treatments and in paediatric cases where radiotherapy is not a suitable adjunct to surgical excision. We present the case of a nine-year-old African Caribbean girl with multiple large and recurrent keloid scars on both ears and bilateral sensorineural deafness. Read More

    Acute hemophilic hemarthrosis: is local cryotherapy recommended?
    Expert Rev Hematol 2017 Oct 20:1-4. Epub 2017 Oct 20.
    b Department of Physical Medicine and Rehabilitation , La Paz University Hospital , Madrid , Spain.
    Introduction: The management of acute hemophilic hemarthrosis (AHH) classically has consisted of factor replacement therapy and RICE (rest, ice, compression and elevation). However, there is still a controversy in the literature regarding the role of local cryotherapy (LC) in AHH. Areas covered: The aim of this article is to review the potential role of LC in AHH. Read More

    Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling.
    PLoS Comput Biol 2017 Oct 5;13(10):e1005736. Epub 2017 Oct 5.
    Mathematical Informatics Laboratory, Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan.
    Experiments with drug-induced epilepsy in rat brains and epileptic human brain region reveal that focal cooling can suppress epileptic discharges without affecting the brain's normal neurological function. Findings suggest a viable treatment for intractable epilepsy cases via an implantable cooling device. However, precise mechanisms by which cooling suppresses epileptic discharges are still not clearly understood. Read More

    Efficacy of cryotherapy plus topical Juniperus excelsa M. Bieb cream versus cryotherapy plus placebo in the treatment of Old World cutaneous leishmaniasis: A triple-blind randomized controlled clinical trial.
    PLoS Negl Trop Dis 2017 Oct 5;11(10):e0005957. Epub 2017 Oct 5.
    Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Cutaneous leishmaniasis is one of the highly prevalent endemic diseases in the Middle East and North Africa. Many treatment modalities have been recommended for this condition but success rates remain limited. Herbal remedies have also been used for treatment but evidence-based clinical trials with these products are sparse. Read More

    Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus.
    World J Gastrointest Endosc 2017 Sep;9(9):480-485
    Section of Gastroenterology and Hepatology, Penn State Hershey Medical Center, Hershey, PA 17033, United States.
    Aim: To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE, with and without dysplasia, or intramucosal adenocarcinoma (IMC).

    Methods: This was a retrospective, single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-naïve or who had persistent intestinal metaplasia (IM), dysplasia, or IMC despite prior therapy. Barrett's mucosa was resected via EMR when clinically appropriate, then patients underwent cryotherapy until eradication or until deemed to have failed treatment. Read More

    Innovative intraoral cooling device better tolerated and equally effective as ice cooling.
    Cancer Chemother Pharmacol 2017 Nov 3;80(5):965-972. Epub 2017 Oct 3.
    Department of Oral Medicine & Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Box 450, 405 30, Gothenburg, Sweden.
    Purpose: Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. Read More

    Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri.
    Med Arch 2017 Aug;71(4):280-283
    University of Tuzla, Faculty of Medicine Tuzla, Tuzla, Tuzla, Bosnia and Herzegovina.
    Introduction: Cervical cancer can be successfully prevented by effective treatment.

    Aim: Analyse of success of cryotherapy in LSIL and ASCUS.

    Materials Et Methods: In retrospective study between January 2016 to March 2017, 3244 PAP test were analysed. Read More

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