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Clin Orthop Relat Res 2018 Sep;476(9):1783-1790

G. Scoccianti, F. Totti, M. Scorianz, D. A. Campanacci, Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy G. Baldi, Department of Medical Oncology, Hospital of Prato, Prato, Italy G. Roselli, Department of Radiology, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy G. Beltrami, Department of Paediatric Orthopaedic Oncology, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy A. Franchi, Department of Translational Research and New Technologies, Department of Anatomic Pathology, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy R. Capanna, Department of Orthopaedics and Traumatology, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

Background: Denosumab is a monoclonal RANKL antibody, which was originally introduced for the treatment of osteoporosis and bone metastases from solid tumors, but more recently has been used for treatment of giant cell tumor of bone (GCTB). In GCTB, denosumab has been used as a single agent in patients with inoperable tumors; it also has been used before surgery in some patients with the aim to downstage the tumor to facilitate a joint-preserving procedure (curettage) rather than a resection. However, few studies are available evaluating the benefits and risks of denosumab for the latter indication. Read More

Klin Lab Diagn 2018 ;63(11):683-685

Diagnostic center № 3 of Moscow City Health Department, 109444, Russia, Moscow.

In the study, comparative analysis before and after the air cryotherapy for the following parameters: total cholesterol (using a set of reagents CHOL_2, automatic biochemical analyzer ADVIA 2400( Siemens), glucose (using a set of reagents Glucose Hexokinase II, automatic biochemical analyzer ADVIA 2400 (Siemens), cholesterol of low-density lipoproteins (using the set of reagents of L-HDL, automatic biochemical analyzer ADVIA 2400 (Siemens). The number of oxidized lipoproteins (LP) was determined by the method of the Muzya G. I. Read More

Br J Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Departments of 1Dermatology and 2Surgery, Medical University of Vienna, Vienna, Austria.

Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union (EU) for locoregional advanced melanoma of American Joint Committee on Cancer (AJCC) stages IIIB, IIIC and IVM1a. Organ transplant recipients (OTRs) are so far excluded from all clinical trials dealing with immunotherapies due to the risk of transplant rejection. A 58-year-old caucasian male with a history of a heart and kidney transplantation in 2014 was diagnosed with melanoma (Breslow thickness of 1. Read More

Dermatol Pract Concept 2019 Jan 31;9(1):4-9. Epub 2019 Jan 31.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Read More

J Orthop Surg Res 2019 Feb 14;14(1):49. Epub 2019 Feb 14.

Department of Orthopedics, Spaarne Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands.

Background: The aim of this study was to define deep tissue temperature during cryotherapy in postoperative hip fracture patients, by using measured skin temperature as input parameter for a simple numerical model. Second, an association was investigated between pain and tissue temperature distribution, to assess cryotherapy-induced analgesia of soft tissue-derived pain.

Methods: Data from 35 participants in an ongoing trial was used. Read More

Bull Soc Pathol Exot 2018 ;111(1):1-4

Service dermatologie CHU de Treichville, université Félix Houphouët Boigny, Abidjan, Côte-d'Ivoire.

We have conducted a retrospective study in the dermatology department of the CHU Treichville in Abidjan during 4 years. Three hundred and fifty cases of venereal warts were recorded with a hospital frequency of 1.5%, an average age of 29. Read More

PLoS One 2019 12;14(2):e0212391. Epub 2019 Feb 12.

[This corrects the article DOI: 10.1371/journal.pone. Read More

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

Pediatr Dermatol 2019 Feb 10. Epub 2019 Feb 10.

Dell Children's Medical Center, Austin, Texas.

The fear of painful procedures is at an increased incidence within the pediatric population. This can be an extremely challenging obstacle in dermatology where injections, blood draws, and cryotherapy are often required during the care of patients. Psychologic techniques based on cognitive behavioral therapy (CBT) can be implemented leading up to and while performing these procedures to help reduce patient anxiety. Read More

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Faculty of Dermatology, College of medicine, King Faisal University, Al Ahsa, Saudi Arabia -31982. Electronic address:

Rev Med Chil 2018 Sep;146(9):1033-1040

Division of Pulmonary and Critical Care Medicine, Mayo Clinic Jacksonville, Florida, United States.

Bronchoscopy cryoprobes are used for palliative treatment of endobronchial obstructions caused by tumors and removal of granulation tissue or foreign bodies. Currently this technology is also used for diagnosis of diffuse interstitial lung disease (ILD). The multidisciplinary team that establishes the clinical, radiological and histopathological correlation in ILD, decides about performing a surgical lung biopsy when the characteristics of the interstitial disease are not similar to Idiopathic Pulmonary Fibrosis (IPF). Read More

Bone Marrow Transplant 2019 Feb 4. Epub 2019 Feb 4.

Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

The conditioning therapy used in connection with haematopoietic stem cell transplantation (HSCT) can induce painful oral mucositis, which has negative impacts on patient quality of life and survival, as well as on health-care costs. While cooling of the oral mucosa (cryotherapy) is regarded as standard prophylaxis against oral mucositis, the long duration of the treatment affects compliance owing to side effects. In this prospective, randomised trial, 94 patients (62 males/32 females; median age 59 years, range 34-69) with a diagnosis of myeloma who were undergoing autologous HSCT were randomised 1:1 to receive cryotherapy for 7 h (N = 46) or 2 h (N = 48). Read More

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Radiofrequency ablation (RFA) is the preferred treatment option for Barrett's esophagus (BE) to achieve complete eradication (CE) of dysplasia (D), and intestinal metaplasia (IM). Cryotherapy, using liquid nitrogen (LNC), is a cold-induced tissue-injury technique option for the ablation of BE. We conducted a systematic review and meta-analysis to assess the overall efficacy and safety of LNC in the treatment of BE. Read More

Cryobiology 2019 Jan 30. Epub 2019 Jan 30.

University of Poitiers, Laboratoire Mobilité Vieillissement Exercice (MOVE)-EA6314, Faculty of Sport Sciences, Poitiers, France. Electronic address:

As soluble intercellular adhesion molecule-1 (sICAM-1) was recently hypothesized to be a key player in the mechanisms involved in exercise-induced muscular damage (EIMD), we investigated its circulating concentration changes in athletes before and after EIMD with and without the use of whole-body cryostimulation (WBC; 3 min at -110 °C) at the exercise end and repeated once a day during 4 days. We previously characterized plasma specimens from 11 endurance athletes who performed twice (randomized crossover design) strenuous running leading to EIMD, followed by passive recovery or WBC. Muscle soreness and inflammatory response were observed in both cases but the use of WBC induced a significant reduction in these responses (PlosOne 2011; 6:e22748). Read More

Int J Dermatol 2019 Mar 31;58(3):365-373. Epub 2019 Jan 31.

Dermatology, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Sao Paulo, Brazil.

Background: Sun exposure may lead to actinic keratoses (AKs), field cancerization, and skin cancer. Effective treatment of AKs and field cancerization is important. Oral and topical retinoids can be used for this purpose. Read More

Int J Gynaecol Obstet 2019 Jan 31. Epub 2019 Jan 31.

Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objective: To assess the cost-effectiveness of HPV-based screening and management algorithms for HPV-positive women in phase 2 of the Cervical Cancer Prevention in El Salvador (CAPE) demonstration, relative to the status quo of Pap-based screening.

Methods: Data from phase 2 of the CAPE demonstration (n=8000 women) were used to inform a mathematical model of HPV infection and cervical cancer. The model was used to project the lifetime health and economic outcomes of HPV testing every 5 years (age 30-65 years), with referral to colposcopy for HPV-positive women; HPV testing every 5 years (age 30-65 years), with immediate cryotherapy for eligible HPV-positive women; and Pap testing every 2 years (age 20-65 years), with referral to colposcopy for Pap-positive women. Read More

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, University of California Davis, Sacramento, CA.

Background: Cryotherapy is a commonly discussed method for treatment of basal cell carcinoma skin cancer. Some uncertainty remains about its efficacy relative to other modalities.

Objective: To determine the efficacy and adverse events profile of cryotherapy for the treatment of basal cell carcinoma compared to other therapeutic options or non-intervention. Read More

J Bodyw Mov Ther 2019 Jan 2;23(1):183-188. Epub 2018 Feb 2.

Department of Physiotherapy, SOAHS, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

Objective: To compare the effects of the application of therapeutic heat and cold on the mechanical response of the median nerve neurodynamic testing.

Design: Single-blinded randomized crossover trial.

Methodology: 56 asymptomatic university students (mean age = 21. Read More

Klin Monbl Augenheilkd 2019 Jan 28;236(1):50-53. Epub 2019 Jan 28.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Münster.

Purpose: Cryotherapy as a destructive procedure is an important alternative to the surgical excision of eyelid tumors.

Methods: We report our own experiences in the cryotherapy of large upper eyelid papillomas using spray- and contact-freezing.

Results/conclusions: Cryotherapy gave excellent results in the treatment of unusually large papillomas. Read More

J Vis Exp 2019 Jan 9(143). Epub 2019 Jan 9.

Department of Surgical Oncology, Centre Léon Bérard; Applications des ultrasons à la thérapie (LabTAU), Institut national de la santé et de la recherche médicale (INSERM), Centre Léon Bérard, Université Lyon 1, Université Lyon.

Today, the only potentially curative option in patients with colorectal liver metastases is surgery. However, liver resection is feasible in less than 20% of patients. Surgery has been widely used in association with radiofrequency, cryotherapy, or microwaves to expand the number of treatments performed with a curative intent. Read More

Wiad Lek 2018 ;71(8):1474-1479

Ośrodek Profilaktyki I Rehabilitacji Creator Sp. z o.o. w Łodzi, Łódź, Polska.

Objective: Introduction: Degenerative spine's changes affect about 50% of population over 55 and 100% of people aged over 65. The disease is clinically manifested by joints' pain and limitation of their motor function. It is also one of the most common reasons for absenteeism at work. Read More

Tuberk Toraks 2018 Dec;66(4):312-316

Clinic of Interventional Pulmonology, Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Introduction: Recently, treatment of endobronchial hamartomas with interventional bronchoscopic methods has become possible. Although there are several reports of therapeutic benefits, the protocol of administration varies between centers and high recurrence rates continue to be a problem. In this study, we aimed to show that cryotherapy applied to the root of the bronchial wall after removal of the intraluminal portion of endobronchial hamartoma with interventional bronchoscopic methods can prevent recurrences. Read More

Medicina (Kaunas) 2019 Jan 22;55(2). Epub 2019 Jan 22.

MediCA Klinika, V.Krėvės 53, LT-50358 Kaunas, Lithuania.

Background and o: Oral mucositis is one of the main adverse events of cancer treatment with chemotherapy or radiation therapy. It presents as erythema, atrophy or/and ulceration of oral mucosa. It occurs in almost all patients, who receive radiation therapy of the head and neck area and from 20% to 80% of patients who receive chemotherapy. Read More

Dermatol Res Pract 2018 24;2018:9014726. Epub 2018 Dec 24.

Department of Clinical Analysis and Biomedicine, State University Maringa, Avenida Colombo, 5790 Jardim Universitário, 87020-900 Maringá, PR, Brazil.

The first choice drugs for the treatment of cutaneous and mucocutaneous leishmaniasis are pentavalent antimonials, sodium stibogluconate, or meglumine antimoniate. However, the treatment with these drugs is expensive, can cause serious adverse effects, and is not always effective. The combination of two drugs by different routes or the combination of an alternative therapy with systemic therapy can increase the efficacy and decrease the collateral effects caused by the reference drugs. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

Plant Dis 2018 Aug 11;102(8):1574-1580. Epub 2018 Jun 11.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of College of Horticulture, Northwest A&F University.

Apple stem grooving virus (ASGV), a difficult-to-eradicate virus from apple propagative materials, causes serious damage to apple production. The use of virus-free plants has been and is an effective strategy for control of plant viral diseases. This study aimed to eradicate ASGV from virus-infected in-vitro-cultured shoots of four apple cultivars and one rootstock by combining thermotherapy with cryotherapy. Read More

Dig Endosc 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.

Photodynamic therapy (PDT), a treatment of choice for cancer, induce photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to the tumor mass, and is an approved curative endoscopic ablative treatment for superficial esophageal squamous cell carcinoma (ESCC) in Japan. PDT has been approved for dysplastic Barrett 's esophagus and as a palliative treatment for patients with symptomatic obstructive esophageal cancer in US. Read More

Cochrane Database Syst Rev 2019 01 22;1:CD001501. Epub 2019 Jan 22.

Department of Obstetrics and Gynaecology, University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.

Background: Heavy menstrual bleeding (HMB) is a significant health problem in premenopausal women; it can reduce their quality of life and can cause social disruption and physical problems such as iron deficiency anaemia. First-line treatment has traditionally consisted of medical therapy (hormonal and non-hormonal), but this is not always successful in reducing menstrual bleeding to acceptable levels. Hysterectomy is a definitive treatment, but it is more costly and carries some risk. Read More

Niger J Clin Pract 2019 Jan;22(1):34-40

Universidad Autónoma de Baja California, Campus Tijuana, Tijuana, Baja California, México.

Objective: The aim of this clinical trial was to assess whether controlled irrigation with three different irrigation regimens with different temperature would result in reduction of post-endodontic pain after one-visit root canal treatment (RCT).

Materials And Methods: A total of 240 (129 females and 111 male) aged 18 - 65 years were referred and integrated in this clinical trial, All patients presented with a vital maxillary or mandibular molar, premolar or front teeth designated for conventional root canal treatment for prosthetic reasons detected with only vital pulps. All canals were cleaned and shaped with Reciproc instruments, and were used with a micro motor (VDW, Munich Germany). Read More

Curr Treat Options Gastroenterol 2019 Jan 19. Epub 2019 Jan 19.

Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY, 11040, USA.

Purpose Of Review: Barrett's esophagus (BE) is the only known measurable factor associated with esophageal adenocarcinoma. The development of endoscopic eradication therapy (EET) has transformed the way BE is managed. Given the fairly recent development of EET, its role in BE is still evolving. Read More

Int J Ophthalmol 2019 18;12(1):165-168. Epub 2019 Jan 18.

Shri Bhagawan Mahavir Vitreo Retinal Services, Sankara Nethralaya, Chennai, Tamil Nadu 600006, India.

The study compared anatomical and functional outcome of a novel technique of encirclage and cryotherapy with the conventional argon laser in the management of traumatic cyclodialysis cleft in 19 patients (10: encirclage and 9: argon laser). The postoperative anatomical success was taken as rise in intraocular pressure (IOP) more than 6 mm Hg or the closure of cleft on gonioscopy or ultrasound biomicroscopy (UBM). Visual outcome was measured as change in logMAR visual acuity. Read More

Urology 2019 Jan 16. Epub 2019 Jan 16.

Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA. Electronic address:

Objective: To investigate safety, efficacy, and quality of life impact of hemi-gland cryotherapy for clinically-significant prostate cancer (CaP), when patient selection and follow-up includes MRI-guided biopsy.

Methods: Twenty-nine men with unilateral CaP (all clinically significant with prostate volume <60 cc) were enrolled in a prospective observational trial of hemi-gland cryotherapy. Mean patient age was 68. Read More

Clin Case Rep 2019 Jan 11;7(1):40-46. Epub 2018 Nov 11.

Queen Mother Hospital for Animals Royal Veterinary College North Mymms, Hertfordshire UK.

A rhomboid blepharoplasty can be used to achieve functional and cosmetic eyelid reconstruction at the medial canthus in the horse. Combination of a rhomboid blepharoplasty with cryotherapy is a treatment option for eyelid ocular squamous cell carcinomas. Read More

Clin Transl Oncol 2019 Jan 16. Epub 2019 Jan 16.

The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.

Objectives: With the maturity of cryotherapy for prostate cancer, the complications after operation are also decreasing, which can improve the prognosis of patients. However, erectile dysfunction (ED) is still one of the main complications after cryotherapy. Therefore, we performed a meta-analysis to evaluate the incidence of erectile dysfunction in patients after cryotherapy. Read More

JAMA Netw Open 2018 May 18;1(1):e180105. Epub 2018 May 18.

RAND Corporation, Santa Monica, California.

Importance: It is critically important to evaluate the effect of nonpharmacological treatments on low back pain and associated disability.

Objective: To determine whether the addition of chiropractic care to usual medical care results in better pain relief and pain-related function when compared with usual medical care alone.

Design, Setting, And Participants: A 3-site pragmatic comparative effectiveness clinical trial using adaptive allocation was conducted from September 28, 2012, to February 13, 2016, at 2 large military medical centers in major metropolitan areas and 1 smaller hospital at a military training site. Read More

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70

Second Orthopedic Division, Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Italy.

Cryotherapy, also called Cryoablation (CA), is a technique that provides a local treatment to various pathological conditions. In Musculoskeletal tumours management, Cryoablation is well accepted and validated as a treatment in palliative cures for metastatic patients. Recently, CA has been proposed also as an alternative to radiofrequency ablation in osteoid osteoma and other benign tumour treatment with promising results. Read More

Angiogenesis 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.

Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing retina and vasculatures to pharmacological intervention, there is currently no approved drug therapy for ROP in preterm infants. Read More

World J Gastroenterol 2019 Jan;25(1):1-41

H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine Medical Center, Orange, CA 92868, United States.

In this paper, I reviewed the emerging field of endoscopic surgery and present data supporting the contention that endoscopy can now be used to treat many foregut diseases that have been traditionally treated surgically. Within each topic, the content will progress as follows: "lessons learned", "technical considerations" and "future opportunities". Lessons learned will provide a brief background and update on the most current literature. Read More

Dermatol Surg 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Background: Recent advances in keloid management favor the administration of combination therapy over monotherapy.

Objective: The authors evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, cryotherapy, and intralesional corticosteroids.

Materials And Methods: The authors performed a retrospective study involving 35 Korean patients. Read More

Eur Urol 2019 Jan 8. Epub 2019 Jan 8.

Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK; Department of Urology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background: Focal cryotherapy can be used to treat patients with clinically significant nonmetastatic prostate cancer to reduce side effects.

Objective: Early-medium-term cancer control and functional outcomes.

Design, Setting, And Participants: A prospective registry-based case series of 122 consecutive patients undergoing focal cryotherapy between October 1, 2013, and November 30, 2016, in five UK centres. Read More

Orthopade 2019 Jan;48(1):77-83

Orthopädische Universitätsklinik Regensburg, Asklepios Klinikum Bad Abbach, Universität Regensburg, 93077, Bad Abbach, Deutschland.

Background: The degeneration of the lumbar facet joint is a multi-factorial process that is closely linked to degeneration of the intervertebral discs and has been implicated as one of the causes of low-back pain of elderly patients in about 15 up to 40% of cases. Moreover, emerging data suggest that increased inflammatory features play an important role in the progression of lumbar facet joint disease and may serve as a link to the afferent pain nerve fibers.

Operative Techniques: Since the first description in 1975 of minimally invasive treatment of lumbar facet joint disease, different techniques have been developed and used with varying results. Read More

Equine Vet J 2019 Jan 13. Epub 2019 Jan 13.

Australian Equine Laminitis Research Unit, School of Veterinary Science, the University of Queensland, Gatton, Queensland, Australia.

Background: Continuous digital hypothermia can prevent the development and progression of laminitis associated with sepsis but its effects on laminitis due to hyperinsulinaemia are unknown.

Objectives: To determine the effects of continuous digital hypothermia on laminitis development in the euglycaemic hyperinsulinaemic clamp model.

Study Design: Randomised, controlled (within subject), blinded, experiment. Read More

Br J Dermatol 2019 Jan 12. Epub 2019 Jan 12.

Erasmus Medical Centre Cancer Institute, Department of Dermatology, Rotterdam, The Netherlands.

Background: The high prevalence of actinic keratosis (AK) requires optimal use of healthcare resources.

Objectives: To gain insight in health care utilization and management of AK, by describing the healthcare utilization of people with AK in a population-based cohort and in a primary and secondary care setting.

Methods: A retrospective cohort study using three complementary data sources was conducted to describe the use of care, diagnosis, treatment, and follow-up of AK patients in the Netherlands. Read More

Medicine (Baltimore) 2019 Jan;98(2):e13962

Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The objective of this study was to evaluate intraoperative hypothermia as a predictor of complication and prognosis in patients with muscle-invasive bladder cancer treated with radical cystectomy.The data of 124 patients treated with radical cystectomy for muscle-invasive bladder cancer in our department, from 2003 to 2016, were retrospectively collected. The patients were divided into 2 groups according to the lowest intraoperative deep body temperature, that is, the hypothermia group (<96. Read More

Cryobiology 2019 Feb 7;86:19-24. Epub 2019 Jan 7.

Faculty of Physiotherapy, University School of Physical Education, Wroclaw, Poland.

The aim of the work was to evaluate changes in selected skin parameters under the influence of low temperature. The tests were conducted on a group of 20 women using whole-body cryotherapy. The average age of participants was 58. Read More

Acta Odontol Scand 2019 Mar 9;77(2):164-167. Epub 2019 Jan 9.

a Department of Endodontics, Faculty of Dentistry , Ondokuz Mayıs University , Samsun , Turkey.

Objective: The aim of this study is to evaluate the effect of intracanal cryotherapy on the fracture resistance of endodontically treated teeth.

Materials And Methods: Sixty single-rooted maxillary lateral incisor teeth with single root canals were selected and randomly divided into two groups (n = 30). The specimens were immersed in distilled water, which was heated to 37 °C during the procedures. Read More

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):133-135

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Genital warts have a big psychological impact on the affected individuals, as the treatment requires time and multiple sessions at a time. They can also increase the chances of acquiring other sexually transmitted diseases. Various treatment options are available including the topical application of imiquimod, podophyllin, trichloroacetic acid application, cryotherapy, and radiofrequency cautery. Read More

J Thorac Dis 2018 Nov;10(11):6298-6309

Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.

Lung cancer is the leading cause of cancer related deaths. Non-small cell lung cancer (NSCLC) accounts for ~85% of lung cancers. Our understanding of driver mutations and genotype directed therapy has revolutionized the management of advanced NSCLC. Read More

BMJ Open Sport Exerc Med 2018 26;4(1):e000477. Epub 2018 Dec 26.

Faculty of Medicine, Laval University, Quebec City, Canada.

Objectives: Rotator cuff tendinopathies are the most common shoulder disorders. As persistent symptoms lasting more than 3 months have been shown to be a strong indicator of poor outcomes, it is important to have successful interventions in the acute stage. However, there is no evidence yet to guide clinical interventions in an acute pain context. Read More

Drugs Context 2018 19;7:212563. Epub 2018 Dec 19.

Department of Pediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Penile warts are the most common sexually transmitted disease in males. Clinicians should be familiar with the proper evaluation and management of this common condition.

Objective: To provide an update on the current understanding, evaluation, and management of penile warts. Read More