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    Insights into cryotherapy and joint bleeding: cryotherapy and hemophilia.
    Blood Coagul Fibrinolysis 2017 Feb 21. Epub 2017 Feb 21.
    aDepartment of Physical Therapy, Faculty of Medical Sciences, Tarbiat Modares University bShahid Beheshti University of Medical Sciences, Tehran.
    There is some controversy over the use of cryotherapy. Low temperatures (Temp) could interfere with coagulation and increase the risk of bleeding. We sought to examine the effect of cryotherapy on joint swelling, temperature, friction, and inflammatory condition after experimental hemarthrosis. Read More

    Cervical cancer screening in rural South Africa among HIV-infected migrant farm workers and sex workers.
    Gynecol Oncol Rep 2017 May 29;20:18-21. Epub 2017 Jan 29.
    Department of Obstetrics, Gynecology & Reproductive Science, Icahn School of Medicine at Mount Sinai, United States.
    At an HIV clinic in the Limpopo province of South Africa, chart reviews revealed long delays in addressing abnormal Pap smears, difficulty in referrals, poor quality and lost results, and increasing cases of cervical cancer. To address these barriers, a "see and treat" approach to screening was proposed. The objective was to integrate this method into current HIV care offered by local providers and to obtain demographic and risk factor data for use in future educational and intervention programs in the region. Read More

    Combined treatment with laser photocoagulation and cryotherapy for threshold retinopathy of prematurity.
    Eur J Ophthalmol 2008 Jan-Feb;18(1):112-117
    Department of Pediatric Ophthalmology, Faculty of Medicine, Masaryk University Hospital, Brno - Czec.
    Purpose: To report the structural, functional, and refractive outcome, safety, and effectiveness of combined cryotherapy and diode laser indirect photocoagulation in the treatment of threshold retinopathy of prematurity (ROP).

    Methods: Medical records of patients developing threshold ROP between 1995 and 2003 were reviewed to identify those with combined treatment and followed up for at least 4 years postoperatively. A total of 94 patients (172 eyes) received combined treatment. Read More

    [Physiotherapeutic proceeding in symptomatic calcaneal spur treatment].
    Wiad Lek 2016 ;69(6):758-764
    Klinika Rehabilitacji i Medycyny Fizykalnej, Katedra Nefrologii i Nadciśnienia Tętniczego, Uniwersytet Medyczny, Łódź, Polska.
    Calcaneal spur is one of the most common disorders associated with foot pain. According to appearance of pain in each step during the day, it is important to find the most effective method of treatment. This article is a review of medical reports about non-operative treatment method. Read More

    Fresh frozen amniotic membrane for conjunctival reconstruction after excision of neoplastic and presumed neoplastic conjunctival lesions.
    Eye (Lond) 2017 Feb 17. Epub 2017 Feb 17.
    Ocular Oncology Centre, Royal Hallamshire Hospital, Sheffield, UK.
    PurposeSuspicious neoplastic conjunctival lesions often require wide excision with tumour-free margins, leaving significant conjunctival defects requiring reconstruction. In this study we report the results of using fresh frozen amniotic membrane grafts (AMG) after wide excision of potentially malignant lesions.MethodsRetrospective review of 53 patients; between January 2011 and April 2014. Read More

    Vascular Impulse Technology versus elevation in the treatment of posttraumatic swelling of extremity fractures: study protocol for a randomized controlled trial.
    Trials 2017 Feb 16;18(1):73. Epub 2017 Feb 16.
    Department for Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen at Heidelberg University Hospital, Ludwigshafen am Rhein, Germany.
    Background: Fractures of the extremities are often complicated by a variable degree of swelling secondary to hemorrhage and soft tissue injury. Patients typically require up to 7 days of inpatient bed rest and elevation to reduce swelling to an acceptable level for operative treatment with internal fixation. Alternatively, an intermittent pneumatic compression device, such as the Vascular Impulse Technology (VIT) system, can be used at the injured extremity to reduce the posttraumatic swelling. Read More

    Clinical analysis of eight patients with blunt main stem bronchial injuries.
    J Thorac Dis 2017 Jan;9(1):194-199
    Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
    Background: Blunt main stem bronchial injuries are rare but potentially life-threatening injuries in clinical. The aim of this study was to sum up the experience on diagnosis and treatment of blunt main stem bronchial injuries.

    Methods: This report retrospective1y analyzed eight cases of main stem bronchial injuries induced by blunt chest trauma between 2013 and 2016 in Tangdu Hospital, Fourth Military Medical University. Read More

    Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone.
    Clin Orthop Relat Res 2017 Feb 14. Epub 2017 Feb 14.
    Department of Orthopaedics, Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background: Liquid nitrogen has been used as adjuvant cryotherapy for treating giant cell tumor (GCT) of bone. However, the liquid phase and ultrafreezing (-196° C) properties increase the risk of damage to the adjacent tissues and may lead to perioperative complications. A novel semisolid cryogen, freezing nitrogen ethanol composite, might mitigate these shortcomings because of less-extreme freezing. Read More

    Practical indications for the management of non--melanoma skin cancer patients.
    G Ital Dermatol Venereol 2017 Feb 14. Epub 2017 Feb 14.
    Institue of Dermatology, Catholic University of Rome, Rome, Italy.
    Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non--melanoma skin cancers (NMSC), are the most common cancers among fair--skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NMSCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Read More

    Rehabilitation of hamstring muscle injuries: a literature review.
    Rev Bras Ortop 2017 Jan-Feb;52(1):11-16. Epub 2016 Dec 15.
    Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Ortopedia e Traumatologia, São Paulo, SP, Brazil.
    Hamstring injuries are among the most frequent in sports. The high relapse rate is a challenge for sports medicine and has a great impact on athletes and sport teams. The treatment goal is to provide the athlete the same functional level as before the injury. Read More

    Recurrent Conjunctival Myofibrosarcoma Managed With Triple Application of Episcleral Brachytherapy.
    Cornea 2017 Feb 8. Epub 2017 Feb 8.
    *Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH; †Department of Pathology, The Ohio State University, Columbus, OH; ‡Department of Ophthalmology, Northwestern Medicine, Chicago, IL; and §Department of Pathology, Cleveland Clinic, Cleveland, OH.
    Purpose: To report a case of recurrent conjunctival myofibrosarcoma treated with wide surgical excision, cryotherapy, and triple sequential applications of episcleral brachytherapy.

    Methods: A single case of recurrent conjunctival myofibrosarcoma.

    Results: A 54-year-old man with a history of a renal transplant presented with a recurrent conjunctival tumor. Read More

    Hypothermia reduces VEGF-165 expression, but not osteogenic differentiation of human adipose stem cells under hypoxia.
    PLoS One 2017 6;12(2):e0171492. Epub 2017 Feb 6.
    Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.
    Cryotherapy is successfully used in the clinic to reduce pain and inflammation after musculoskeletal damage, and might prevent secondary tissue damage under the prevalent hypoxic conditions. Whether cryotherapy reduces mesenchymal stem cell (MSC) number and differentiation under hypoxic conditions, causing impaired callus formation is unknown. We aimed to determine whether hypothermia modulates proliferation, apoptosis, nitric oxide production, VEGF gene and protein expression, and osteogenic/chondrogenic differentiation of human MSCs under hypoxia. Read More

    Associations of high-dose melphalan pharmacokinetics and outcomes in the setting of a randomized cryotherapy trial.
    Clin Pharmacol Ther 2017 Feb 4. Epub 2017 Feb 4.
    Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
    High dose melphalan followed by autologous stem cell transplantation remains standard of care for eligible patients with multiple myeloma, but disease response and toxicity, including severe mucositis, varies among patients. Our randomized trial investigated duration of cryotherapy (2 and 6 hours) for reduction of mucositis prevalence and severity and explored factors associated with variability in pharmacokinetics and outcomes from melphalan therapy. The results demonstrate 2-hour is at least as effective as 6-hour cryotherapy in decreasing severe mucositis. Read More

    Successful Treatment of Classic Kaposi Sarcoma With Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet (Nd: YAG) Laser: A Preliminary Study.
    Dermatol Surg 2017 Feb 1. Epub 2017 Feb 1.
    *Both authors are affiliated with the Department of Dermatology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
    Background: Kaposi sarcoma (KS) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. The treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema.

    Objective: This article presents 7 cases with classic KS treated with the long-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Read More

    Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging.
    Arch Pathol Lab Med 2017 Feb 3. Epub 2017 Feb 3.
    From the Departments of Pathology (Drs Ellis, Harik, Cohen, and Osunkoya), Urology (Dr Osunkoya), and the Winship Cancer Institute (Dr Osunkoya), Emory University School of Medicine, Atlanta, Georgia; and the Department of Pathology, Veterans Affairs Medical Center, Atlanta, Georgia (Dr Osunkoya).
    Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. Read More

    Surgical Technique: Jumper's Knee-Arthroscopic Treatment of Chronic Tendinosis of the Patellar Tendon.
    Arthrosc Tech 2016 Dec 12;5(6):e1419-e1424. Epub 2016 Dec 12.
    Department of Orthopedic Surgery, Saarland University, Homburg/Saar, Germany.
    Chronic patellar tendinosis (jumper's knee) is a common problem among athletes. Conservative treatment is successful in most of the cases including, among others, the use of nonsteroidal anti-inflammatory drugs, local cryotherapy, eccentric muscle training, limitation of sports activity, and local infiltration. In approximately 10% of conservatively treated patients, conservative treatment fails and surgery is required. Read More

    Effect of Delayed Digital Hypothermia on Lamellar Inflammatory Signaling in the Oligofructose Laminitis Model.
    J Vet Intern Med 2017 Feb 1. Epub 2017 Feb 1.
    Department of Veterinary Clinical Sciences, Ohio State University, Columbus, OH.
    Background: In the oligofructose (OF) model of sepsis-related laminitis (SRL), digital hypothermia ("cryotherapy") initiated before the onset of clinical signs is reported not only to limit lamellar injury, but also to cause marked inhibition of lamellar inflammatory signaling.

    Hypothesis/objectives: Because hypothermia also has been reported to be protective when not initiated until the onset of lameness in the OF model of SRL, we hypothesized that the lamellar protection conferred by hypothermia is caused by local lamellar inhibition of inflammatory signaling as described when hypothermia was initiated earlier in the disease process.

    Animals: Eight Standardbred geldings aged 3-11 years with no lameness and no abnormalities of the feet detectable by gross or radiographic examination. Read More

    Cold-Water Mediates Greater Reductions in Limb Blood Flow than Whole Body Cryotherapy.
    Med Sci Sports Exerc 2017 Jan 30. Epub 2017 Jan 30.
    1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom; 2School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Australia; 3Extreme Environments Laboratory, Department of Sport and Exercise Science, University of Portsmouth, Portsmouth, United Kingdom.
    Purpose: Cold-water immersion (CWI) and whole body cryotherapy (WBC) are widely used recovery methods in an attempt to limit exercise-induced muscle damage, soreness and functional deficits after strenuous exercise. The aim of this study was to compare the effects of ecologically-valid CWI and WBC protocols on post-exercise lower limb thermoregulatory, femoral artery and cutaneous blood flow responses.

    Methods: Ten males completed a continuous cycle exercise protocol at 70% maximal oxygen uptake until a rectal temperature of 38°C was attained. Read More

    Initiation of Therapeutic Hypothermia in the Emergency Department: A Quality Improvement Project.
    Adv Emerg Nurs J 2017 Jan/Mar;39(1):52-58
    St John Medical Center, Tulsa, Oklahoma (Dr Yochum); and Missouri State University, Springfield (Dr Utley).
    Therapeutic hypothermia (TH) postresuscitation has been recommended by the American Heart Association (AHA) since 2005. Early initiation of TH and fast achievement of goal temperatures have been associated with better neurological outcomes. The objective of this study was to evaluate the effectiveness of a specific TH protocol for the emergency department (ED) in increasing ED use of TH and decreasing the time from return of spontaneous circulation (ROSC) to initiation of cooling measures. Read More

    [Evidence-based therapy for tendinopathy of the knee joint : Which forms of therapy are scientifically proven?]
    Unfallchirurg 2017 Jan 30. Epub 2017 Jan 30.
    Orthopädische Klinik, Medizinische Hochschule Hannover, Anna-von-Borries-Straße 1-7, 30625, Hannover-Kleefeld, Deutschland.
    Tendinopathy in the region of the knee joint is a common pathological disorder. People active in sports, in particular, have a high probability of suffering from tendinopathy. Despite its high clinical relevance, the level of evidence of therapy options for tendinopathy in the knee region differs greatly. Read More

    Acute effects of partial-body cryotherapy on isometric strength: maximum handgrip strength evaluation.
    J Strength Cond Res 2017 Jan 20. Epub 2017 Jan 20.
    1 Department of Experimental Medicine, University of Genoa2 Motor Science Research Center, School of Exercise & Sport Sciences, SUISM, Department of Medical Sciences, University of Torino, Torino, Italy3 Department of Biomedical Sciences for Health , University of Milano, Milano, Italy4 Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.
    The aim of the study was to evaluate the influence of a single partial-body cryotherapy (PBC) session on the maximum handgrip strength (JAMAR Hydraulic Hand dynamometer). Two hundred healthy adults were randomized into a PBC group and a control group (50 males and 50 females in each group). After the initial handgrip strength test (T0), the experimental group performed a 150 seconds session of PBC (temperature range between -130 and -160 °C), whilst the control group stayed in a thermo neutral room (22. Read More

    Non-Surgical Ablative Therapy for Management of Small Renal Masses-Current Status and Future Trends.
    Indian J Surg Oncol 2017 Mar 15;8(1):39-45. Epub 2016 Dec 15.
    Department of Urology and Nephrology, Darent Valley Hospital, Darenth Wood Road, Dartford, Kent, DA2 8DA UK.
    A large number of small renal masses (SRMs) with size less than 4 cm are being identified due to advances in diagnostic imaging. As the natural history of these tumours remains unknown, there is no reliable way to predict their behaviour or future growth. Although, partial nephrectomy is the gold standard for treatment of these tumours, ablative non-surgical therapies such as cryoablation and radiofrequency ablation provide a less invasive option of treatment with comparable oncological outcomes. Read More

    Comparison of the efficacy of four endobronchial ablation techniques in dogs.
    Exp Ther Med 2017 Jan 1;13(1):169-177. Epub 2016 Dec 1.
    Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China.
    The present study aimed to evaluate the safety and efficacy of four commonly used ablation techniques, namely neodymium-doped yttrium aluminium garnet (Nd:YAG) laser therapy, argon plasma coagulation (APC), high-frequency electrocautery and CO2 cryotherapy. The techniques were performed at various powers or impedance settings, and for various durations, on the trachea of beagle dogs. Pathological changes of the tracheal wall were assessed by bronchoscopy. Read More

    Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
    N Engl J Med 2017 01 24;376(4):318-329. Epub 2017 Jan 24.
    From the University of Michigan, Ann Arbor (F.W.M., F.S.S.), and Wayne State University, Detroit (K.L.M., S. Shankaran) - both in Michigan; University of Utah, Salt Lake City (R. Holubkov, B.B., K.P., M.R.G., K.S.B., A.E.C., J.M.D.); Kennedy Krieger Institute and Johns Hopkins University (B.S.S., J.R.C.) and Johns Hopkins Children's Center (U.S.B.), Baltimore, and the National Heart, Lung, and Blood Institute, Bethesda (V.L.P.) - both in Maryland; Children's Hospital of Philadelphia, Philadelphia (V.M.N., A.T.), University of Pittsburgh Medical Center, Pittsburgh (E.L.F.), and Penn State Children's Hospital, Hershey (N.J.T.) - all in Pennsylvania; Birmingham Children's Hospital, Birmingham (B.R.S.), Great Ormond Street Hospital, London (S. Skellett), Alder Hey Children's Hospital, Liverpool (P.B.B.), and University Hospital Southampton, Southampton (J.P.) - all in the United Kingdom; Hospital for Sick Children, Toronto (J.S.H.); Children's National Medical Center, Washington, DC (J.T.B.); Duke Children's Hospital, Durham, NC (G.O.-A.); Children's Hospital Los Angeles (C.J.L.N.) and Mattel Children's Hospital UCLA (R. Harrison), Los Angeles, Children's Hospital of Orange County, Orange (A.J.S.), University of California, San Francisco Benioff Children's Hospital, San Francisco (P.M.), and Loma Linda University Children's Hospital, Loma Linda (M.M.) - all in California; Children's Medical Center Dallas, University of Texas Southwestern Medical School, Dallas (J.D.K.); University of Texas Health Sciences Center at San Antonio, San Antonio (T.W.); Children's Healthcare of Atlanta, Atlanta (N.P., N.K.C.); Washington University, St. Louis (J.A.P.); Phoenix Children's Hospital, Phoenix, AZ (H.J.D.); the Children's Hospital of Alabama, Birmingham (J.A.); Children's Hospital of New York, Columbia University Medical Center, New York (C.L.S.), and Golisano Children's Hospital, University of Rochester Medical Center, Rochester (E.W.J.) - both in New York; Ann and Robert Lurie Children's Hospital of Chicago, Chicago (D.M.G.); Seattle Children's Hospital, Seattle (J.J.Z.); Kosair Children's Hospital, University of Louisville, Louisville, KY (M.B.P.); University of Tennessee Health Science Center, Memphis (S. Shah); Children's Hospital and Clinics of Minnesota, Minneapolis (J.E.N.); Nationwide Children's Hospital, Columbus, OH (E.L.); Children's Hospital Colorado, Aurora (E.L.D.); Medical College of Wisconsin, Milwaukee (M.T.M.); and Arkansas Children's Hospital, Little Rock (R.C.S.).
    Background Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after in-hospital cardiac arrest are limited. Methods In a trial conducted at 37 children's hospitals, we compared two temperature interventions in children who had had in-hospital cardiac arrest. Within 6 hours after the return of circulation, comatose children older than 48 hours and younger than 18 years of age were randomly assigned to therapeutic hypothermia (target temperature, 33. Read More

    Subjective evaluation of the effectiveness of whole-body cryotherapy in patients with osteoarthritis.
    Reumatologia 2016 30;54(6):291-295. Epub 2016 Dec 30.
    Rehabilitation Center, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.
    Objectives: One of the treatments for osteoarthritis (OA) is whole-body cryotherapy (WBC). The aim of this study is to assess the effect of whole-body cryotherapy on the clinical status of patients with osteoarthritis (OA), according to their subjective feelings before and after the application of a 10-day cold treatment cycle. The aim is also to assess the reduction of intensity and frequency of pain, the reduction of the painkiller medication used, and to assess the possible impact on physical activity. Read More

    Intralesional immunotherapy compared to cryotherapy in the treatment of warts.
    Int J Dermatol 2017 Jan 21. Epub 2017 Jan 21.
    Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background: Warts are the most common clinical manifestation of the human papilloma-virus infection in the skin and mucous membranes. In spite of the various therapeutic modalities for nongenital skin warts, there is still no single method to be used as an approved treatment. In this study, we compared the efficacy of immunotherapy and cryotherapy on wart lesions. Read More

    Junctional Ectopic Tachycardia Localization and Procedural Approach using Cryoablation.
    Pacing Clin Electrophysiol 2017 Jan 18. Epub 2017 Jan 18.
    Department of Pediatrics, The University of Wisconsin - Madison, Madison, Wisconsin.
    Background: Idiopathic junctional ectopic tachycardia (JET) may still be difficult to control with antiarrhythmic therapy. Transcatheter ablation can be challenging and may be associated with a high risk of unintended atrioventricular block. The objective of this manuscript is to report the procedural technique, the location of the successful ablation, and the procedural characteristics while utilizing 3D mapping for cryoablation of JET. Read More

    Remote Postconditioning Alone and Combined with Hypothermia Improved Postresuscitation Cardiac and Neurological Outcomes in Swine.
    Biomed Res Int 2016 20;2016:6743648. Epub 2016 Dec 20.
    Department of Emergency Medicine, Yuyao People's Hospital, Medical School of Ningbo University, Ningbo, China; Institute of Emergency Medicine, Medical School of Ningbo University, Ningbo, China.
    Objective. Previously, we demonstrated that remote ischemic postconditioning (RIpostC) improved postresuscitation myocardial and cerebral functions in rat. Here, we investigated the effects of RIpostC alone and combined with therapeutic hypothermia (TH) on cardiac and neurological outcomes after CPR in swine. Read More

    Impact of visual inspection with acetic acid plus cryotherapy "see and treat" approach on the reduction of the population burden of cervical preinvasive lesions in Southeast Nigeria.
    Niger J Clin Pract 2017 Feb;20(2):239-243
    Department of Obstetrics and Gynecology, Federal Teaching Hospital, Abakaliki, Nigeria.
    Objective: The aim of this study is to determine the impact of visual inspection with acetic acid (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical squamous intraepithelial lesion (SIL).

    Methods: Women in four rural communities in Southeast Nigeria were screened with VIA. Women who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria. Read More

    An expert system for selecting wart treatment method.
    Comput Biol Med 2017 Feb 6;81:167-175. Epub 2017 Jan 6.
    Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Victoria 3217, Australia.
    As benign tumors, warts are made through the mediation of Human Papillomavirus (HPV) and may grow on all parts of body, especially hands and feet. There are several treatment methods for this illness. However, none of them can heal all patients. Read More

    The Efficacy of Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-analysis.
    Front Med (Lausanne) 2016 27;3:71. Epub 2016 Dec 27.
    Department of Surgery, The University of Hong Kong , Pokfulam , Hong Kong.
    Keloid is a cutaneous dermal outgrowth resulting from uncontrolled deposition of collagen and glycosaminoglycan around the wound. The uncontrolled and persistent growth of keloids scar will result in cosmetic disfigurement, functional impairment, and affect the quality of life. Triamcinolone acetonide (TAC) is traditionally employed in treating keloid scars. Read More

    An in vitro analysis of the size and shape of cryolesions for facet joint denervation.
    Clin Neurol Neurosurg 2017 Feb 4;153:87-92. Epub 2017 Jan 4.
    Department of Orthopaedic and Trauma Surgery, University Hospital Freiburg, Freiburg, Germany.
    Objectives: Lumbar facet joint syndrome (LFJS) is the cause of lower back pain in 15-54% of the patients. Clinical studies of cryotherapy for LFJS have reported promising outcomes. However, few studies have focused on the technical aspects of cryoneurolysis for LFJS. Read More

    Efficacy of superficial cryotherapy on the eyebrows of patients with alopecia universalis also treated with contact immunotherapy on the scalp: a prospective, split-face comparative study.
    Int J Dermatol 2017 Feb;56(2):184-189
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Background: Few treatment modalities are available for treating alopecia areata (AA) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with AA of the eyebrow. Read More

    Pain Analysis in Patients with Pancreatic Carcinoma: Irreversible Electroporation versus Cryoablation.
    Biomed Res Int 2016 15;2016:2543026. Epub 2016 Dec 15.
    Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
    The aim of this article is to evaluate and compare the postprocedure pain in patients with pancreatic carcinoma treated with irreversible electroporation (IRE) and cryoablation (CRYO). We compared 22 patients with 22 lesions in pancreas treated with IRE and 26 patients with 27 lesions treated with cryosurgery. All the patients in the two groups were under celiac plexus block (CPB) treatment to alleviate the postprocedure pain. Read More

    Measurement of Thermal Conductivity of Porcine Liver in the Temperature Range of Cryotherapy and Hyperthermia (250~315k) by A Thermal Sensor Made of A Micron-Scale Enameled Copper Wire.
    Cryo Letters 2016 Nov/Dec;37(6):427-431
    Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, CHina.
      BACKGROUND: Cryotherapy and hyperthermia are effective treatments for several diseases, especially for liver cancers. Thermal conductivity is a significant thermal property for the prediction and guidance of surgical procedure. However, the thermal conductivities of organs and tissues, especially over the temperature range of both cryotherapy and hyperthermia are scarce. Read More

    SURGICAL OUTCOMES AND COMPLICATIONS OF RHEGMATOGENOUS RETINAL DETACHMENT IN EYES WITH CHORIORETINAL COLOBOMA: The Results of the KKESH International Collaborative Retina Study Group.
    Retina 2017 Jan 6. Epub 2017 Jan 6.
    *Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; †Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; ‡Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India; §Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; ¶Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, India; **Department of Ophthalmology, Universidade Estadual de Londrina, Londrina, Brazil; ††Banker's Retina Clinic and Laser Centre, Gujarat, India; and ‡‡Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Purpose: To study the outcomes of management of rhegmatogenous retinal detachment in eyes with chorioretinal colobomas.

    Methods: A retrospective review of 119 patients (119 eyes) with chorioretinal colobomas who underwent surgical repair for rhegmatogenous retinal detachment was performed. Data were collected on the site of the retinal break, type of surgery, anatomical success, and complications. Read More

    Evaluation of Follow-Up and Treatment Results in Coats' Disease.
    Turk J Ophthalmol 2016 Oct 17;46(5):226-231. Epub 2016 Oct 17.
    İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.
    Objectives: The aim of this study was to evaluate the clinical features, follow-up and treatment results of patients diagnosed with Coats' disease.

    Materials And Methods: Medical records of 27 patients diagnosed with Coats' disease in our clinic were reviewed retrospectively. All patients underwent complete ophthalmological examination and fundus photography was taken. Read More

    Does photobiomodulation therapy is better than cryotherapy in muscle recovery after a high-intensity exercise? A randomized, double-blind, placebo-controlled clinical trial.
    Lasers Med Sci 2017 Feb 5;32(2):429-437. Epub 2017 Jan 5.
    Laboratory of Phototherapy in Sports and Exercise, Nove de Julho University (UNINOVE), São Paulo, SP, Brazil.
    This study aimed to determine the effectiveness of photobiomodulation therapy (PBMT) and cryotherapy, in isolated and combined forms, as muscle recovery techniques after muscle fatigue-inducing protocol. Forty volunteers were randomly divided into five groups: a placebo group (PG); a PBMT group (PBMT); a cryotherapy group (CG); a cryotherapy-PBMT group (CPG); and a PBMT-cryotherapy group (PCG). All subjects performed four sessions at 24-h intervals, during which they submitted to isometric assessment (MVC) and blood collection in the pre-exercise period, and 5 and 60 min post-exercise, while the muscle fatigue induction protocol occurred after the pre-exercise collections. Read More

    Novel Insights on Understanding of Keloid Scar: Article Review.
    J Am Coll Clin Wound Spec 2015 Dec 30;7(1-3):1-7. Epub 2016 Nov 30.
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States.
    Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. Read More

    Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases.
    J Craniomaxillofac Surg 2017 Feb 19;45(2):244-251. Epub 2016 Nov 19.
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:
    Purpose: To investigate and compare the probability of recurrence of keratocystic odontogenic tumors (KCOTs) for different variables and treatment protocols.

    Materials And Methods: An electronic search was undertaken in April 2016 that included clinical series of KCOTs reporting recurrences. Untransformed proportions and meta-analyses were performed to estimate the probability/risk of recurrence, according to several variables. Read More

    Hypothermia for Neuroprotection in Convulsive Status Epilepticus.
    N Engl J Med 2016 12;375(25):2457-2467
    From the Medical-Surgical Intensive Care Unit (S.L., V. Laurent, J.H.-G., B.P., S.M., J.-P.B.) and the Neurology and Stroke Department (F.P.), Centre Hospitalier de Versailles-Site André Mignot, Versailles, INSERM Unité 970 (Team 4), Paris Cardiovascular Research Center (S.L., A.C.), the Medical Intensive Care Unit (V. Lemiale, E.C., E.A.) and Department of Biostatistics and Medical Information (M.R.-R.), Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), the Medical Intensive Care Unit, Cochin University Hospital, Hopitaux Universitaires-Paris Centre, AP-HP (F.D., G.G., N.M., A.C.), the Medical Intensive Care Unit (I.M.) and Neurophysiology Department (Y.-R.T.-D.), Lariboisière University Hospital, AP-HP, INSERM Unité 1153 (ECSTRA Team), Université Paris Diderot, Sorbonne Paris Cité (M.R.-R.), and Paris Descartes University, Sorbonne Paris Cité-Medical School (A.C.), Paris, the Medical Intensive Care Unit, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg (M. Schenck), and the Medical Intensive Care Unit, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, and Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg (J.B.-H.), Strasbourg, the Medical-Surgical Intensive Care Unit, Centre Hospitalier de Melun, Melun (J.C.), the Anesthesiology and Critical Care Department, Toulouse University Hospital, University Toulouse 3 Paul Sabatier, Toulouse (M. Srairi), the Medical-Surgical Intensive Care Unit, Centre Hospitalier de Montreuil, Montreuil (A.H.), the Medical-Surgical Intensive Care Unit, Centre Hospitalier du Mans, Le Mans (T.R.), the Intensive Care Units, Division of Anesthesia, Intensive Care, Pain, and Emergency Medicine, University Hospital of Nîmes, Nîmes (B.L.), and the Medical-Surgical Intensive Care Unit, Centre Hospitalier Victor Dupouy, Argenteuil (M.T.) - all in France.
    Background Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus. Methods In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard care alone; 268 patients were included in the analysis. Read More

    Use of visual inspection with acetic acid, Pap smear, or high-risk human papillomavirus testing in women living with HIV/AIDS for posttreatment cervical cancer screening: same tests, different priorities.
    AIDS 2017 Jan;31(2):233-240
    aAcademic Model Providing Access to Healthcare (AMPATH) Partnership bDepartment of Reproductive Health, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya cDepartment of Biostatistics, Center for Statistical Science, Brown University School of Public Health, Providence, Rhode Island, USA dDepartment of Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada eDepartment of Pathology, Brown University, Providence, Rhode Island, USA fDepartment of Pathology, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya gDepartment of Obstetrics and Gynecology, The Miriam Hospital, Brown University, Providence, Rhode Island hDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
    Objectives: Few studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect posttreatment cervical disease in HIV-infected women in Kenya.

    Design: This is a prospective cohort study. Read More

    Benign tracheal stenosis a case report and up to date management.
    Ann Transl Med 2016 Nov;4(22):451
    Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece.
    Benign tracheal stenosis is situation that occurs usually after stress is applied to a certain area in the trachea during the intubation of a patient or inflammation caused during an infection. In the current case report we will present a 65-year-old man with a benign tracheal stenosis due to a 15-day intubation with a high pressure and low volume intubation tube. Current methodology was applied in his case with an excellent result with a 1-year follow up. Read More

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