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    The Use of Cryotherapy for the Prevention of Wound Complications in the Treatment of Calcaneal Fractures.
    J Foot Ankle Surg 2018 May - Jun;57(3):436-439
    Professor, Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
    We analyzed the risk factors for skin infection and necrosis after calcaneal fracture surgery and evaluated the effect of cryotherapy in preventing postoperative skin infections and necrosis. We studied 129 calcaneal fracture patients (148 feet) who had undergone open reduction and internal fixation from January 2008 to December 2010. Three groups included were: control (44 patients; 49 feet), preoperative cryotherapy (43 patients; 48 feet), and perioperative cryotherapy (42 patients; 51 feet). Read More

    Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):221-226. Epub 2018 Mar 22.
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy.

    Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy. Read More

    Cold therapy to prevent paclitaxel-induced peripheral neuropathy.
    Support Care Cancer 2018 Apr 21. Epub 2018 Apr 21.
    Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair Street, Suite 850, Chicago, IL, 60611, USA.
    Purpose: This case-control study was designed to assess the efficacy of cryotherapy to prevent paclitaxel-induced painful peripheral neuropathy in women with breast cancer.

    Methods: Participants served as their own paired control, with randomization of the cooled glove/sock to either the dominant or the non-dominant hand/foot, worn for 15 min prior to, during, and 15 min after completion of the paclitaxel infusion. Outcome measures included the Neuropathic Pain Symptom Inventory, the Brief Pain Inventory, and quantitative sensory testing. Read More

    Current Technique and Application of Percutaneous Cryotherapy.
    Rofo 2018 Apr 17. Epub 2018 Apr 17.
    Department of Diagnostic&Interventional Radiology, Philipps-University Marburg, Germany.
    Purpose:  Local ablative therapies have become an established treatment option in interventional oncology. Radiofrequency ablation (RFA) and microwave ablation (MWA) are a standard of care in the treatment of hepatocellular carcinoma (HCC). Currently, there is an increasing interest in cryotherapy, one of the oldest ablation techniques. Read More

    New technologies and techniques for prostate cancer focal therapy: a review of the current literature.
    Minerva Urol Nefrol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Urology, L'Institut Mutualiste Montsouris, Paris, France -
    Background: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa).

    Methods: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. Read More

    Surgical Management of Coats Disease.
    Asia Pac J Ophthalmol (Phila) 2018 Mar 27. Epub 2018 Mar 27.
    Department of Ophthalmology, Kindai University Faculty of Medicine, Osaka, Japan.
    Coats disease is a sporadic, chronic retinal vascular disorder with telangiectatic and aneurysmal retinal vessels, with retinal exudation and retinal detachment in severe cases. Various treatment modalities have been used, including laser therapy, cryotherapy, anti‒vascular endothelial growth factor (VEGF) therapy, and surgery. Anti-VEGF therapy seems to be effective in reducing exudative changes and is often combined with other treatment modalities. Read More

    Evaluation of digital cryotherapy using a commercially available sleeve style ice boot in healthy horses and horses receiving intravenous endotoxin.
    Equine Vet J 2018 Apr 13. Epub 2018 Apr 13.
    Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, Pennsylvania, USA.
    Background: Continuous digital cryotherapy experimentally prevents development and reduces severity of sepsis-associated laminitis. A sleeve style ice boot where ice is in direct contact with the skin, and water drains from the boot is being used clinically for distal limb cryotherapy. The degree of cooling achieved by this boot is unknown. Read More

    Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers.
    Front Oncol 2018 28;8:85. Epub 2018 Mar 28.
    Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States.
    Since the 1920s the gold standard for treating cancer has been surgery, which is typically preceded or followed with chemotherapy and/or radiation, a process that perhaps contributes to the destruction of a patient's immune defense system. Cryosurgery ablation of a solid tumor is mechanistically similar to a vaccination where hundreds of unique antigens from a heterogeneous population of tumor cells derived from the invading cancer are released. However, releasing tumor-derived self-antigens into circulation may not be sufficient enough to overcome the checkpoint escape mechanisms some cancers have evolved to avoid immune responses. Read More

    Treatment of primary tracheal glomus tumors: Two case reports and a literature review.
    Medicine (Baltimore) 2018 Apr;97(15):e0374
    Department of Thoracic Sugery, Sichuan University, West China Hospital, Chengdu, China.
    Rationale: Glomus tumors (GTs) are rare soft tissue neoplasms. Several treatment options have been reported for tracheal GTs including thoracotomy, bronchoscopic electrocautery, Nd: YAG laser, and cryotherapy. However, few studies have evaluated the ideal treatment for tracheal GTs. Read More

    Early salivary changes in multiple myeloma patients undergoing autologous HSCT.
    Oral Dis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dentistry, Radboudumc, Nijmegen, The Netherlands.
    Objective: One explorative observational study in 2 parts was performed to examine early salivary changes in relation to oral mucositis (OM) in multiple myeloma patients treated with high-dose melphalan and autologous hematopoietic stem cell transplantation (HSCT). As cryotherapy was introduced after part A as regular care, its effect on OM could be evaluated.

    Methods: Unstimulated (UWS) and stimulated (SWS) whole mouth saliva was collected and OM was scored with the OMNI instrument at days -3, 0, 4, 7, 11 and 14 after HSCT. Read More

    Nonoperative Endoscopic Management of Benign Tracheobronchial Disorders.
    Thorac Surg Clin 2018 May;28(2):243-247
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Founders 7, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
    Modern thoracic surgery requires knowledge and skill in advanced bronchoscopic techniques. Rigid bronchoscopy remains a workhorse for the management of central airway obstruction. Dilation of tracheal strictures is now much simpler with the advent of the balloon dilator, which can be passed through a therapeutic bronchoscope. Read More

    Adjuvant androgen-deprivation therapy following prostate total cryoablation in high-risk localized prostate cancer patients - Open-labeled randomized clinical trial.
    Cryobiology 2018 Apr 5. Epub 2018 Apr 5.
    Department of Urology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, ROC. Electronic address:
    Purpose: To investigate the efficacy and safety profile of 12-month adjuvant androgen-deprivation therapy (ADT) following total-gland cryoablation (TGC) in patients with high-risk localized prostate cancer (HRLPC).

    Materials And Methods: This open-label randomized trial included 38 HRLPC patients who received TGC between July 2011 and March 2013. Within 4 weeks after TGC, subjects were randomly assigned (1:1) to either the 12-month adjuvant ADT or non-adjuvant ADT group. Read More

    Multifocal nitrous oxide cryoballoon ablation with or without EMR for treatment of neoplastic Barrett's esophagus.
    Gastrointest Endosc 2018 Apr 4. Epub 2018 Apr 4.
    Digestive and Liver Disease, Columbia University Medical Center, New York.
    Background And Aims: Endoscopic cryotherapy can eradicate neoplastic Barrett's esophagus (BE). A new contact cryoballoon focal ablation system (CbFAS)) freezes esophageal mucosa with nitrous oxide. We studied the safety and efficacy of CbFAS for complete eradication of neoplastic Barrett's esophagus. Read More

    Sinecatechins 10% ointment for genital warts: Case report of a beneficial reaction in an HIV-positive woman.
    Int J STD AIDS 2018 Jan 1:956462418763888. Epub 2018 Jan 1.
    Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.
    Patients with HIV infection are more likely to develop anogenital warts compared to HIV-negative people and are susceptible to treatment failures and recurrences. We report a case of extensive vulvar warts in an HIV-positive woman successfully treated with sinecatechins ointment. After the failure of a combination of cryotherapy and imiquimod 5% cream, we started therapy with sinecatechins 10% ointment. Read More

    Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases.
    Intern Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of General Surgical Science, Gunma University Graduate School, Japan.
    A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing AFP with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy. Read More

    The Effects of Cryotherapy on Knee Joint Position Sense and Force Production Sense in Healthy Individuals.
    J Hum Kinet 2018 Mar 23;61:39-51. Epub 2018 Mar 23.
    Jerzy Kukuczka Academy of Physical Education in Katowice, Department of Human Motor Behavior, Katowice, Poland.
    The proprioceptive information received from mechanoreceptors is potentially responsible for controlling the joint position and force differentiation. However, it is unknown whether cryotherapy influences this complex mechanism. Previously reported results are not universally conclusive and sometimes even contradictory. Read More

    Harefuah 2018 Mar;157(3):149-153
    Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Introduction: Retinoblastoma (RB) is a malignant tumor presenting in the eyes of infants and children, which endangers life, the eye and vision. The treatment of RB has undergone marked changes in recent years, and great progress has been made in our ability to preserve eyes. Over the last three decades most Israeli patients with RB have been treated in the National Specialty Ocular Oncology Service at the Hadassah-Hebrew University Medical Center in Jerusalem. Read More

    Implementation of a human papillomavirus screen-and-treat model in Mwanza, Tanzania: training local healthcare workers for sustainable impact.
    Int Health 2018 May;10(3):197-201
    University of California, Los Angeles, Department of Obstetrics and Gynecology, Los Angeles, CA, USA.
    Background: The purpose of this study is to evaluate the development of a 1-wk screening campaign and efforts towards the implementation of a sustainable system that addresses cervical cancer in Mwanza, Tanzania with a screen-and-treat model utilizing visual inspection of the cervix with acetic acid (VIA) and cryotherapy.

    Methods: In partnership with CureCervicalCancer (CCC), a non-profit organization based in Los Angeles, CA, USA, 11 medical students at the University of California, Irvine School of Medicine established a model for sustainable human papillomavirus screening practices in Mwanza, Tanzania. This study both quantitatively and qualitatively assesses the successes and limitations of the program model. Read More

    Amniotic Membrane Transplantation in Surgical Treatment of Conjunctival Melanoma: Long-term Results.
    Turk J Ophthalmol 2018 Feb 23;48(1):15-18. Epub 2018 Feb 23.
    Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey.
    Objectives: To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation.

    Materials And Methods: Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lamellar sclerectomy in cases with episcleral involvement, and ocular surface grafting with cryopreserved amniotic membrane. Complications and tumor control rates were evaluated. Read More

    Update on the Treatment of molluscum Contagiosum in children.
    Actas Dermosifiliogr 2018 Mar 22. Epub 2018 Mar 22.
    Servicio de Dermatología, Hospital Infantil del Niño Jesús, Madrid, España. Electronic address:
    Molluscum contagiosum is one of the most common viral infections in childhood. It is a benign and usually self-limiting infection, but its treatment in children can be challenging, particularly when the patient presents multiple lesions or when lesions are symptomatic or highly visible. Several treatment options exist. Read More

    Nonsurgical treatment of nonmelanoma skin cancer in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):177-187. Epub 2017 Nov 3.
    Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Nonmelanoma skin cancer (NMSC) is the most common cancer, with the median age at NMSC diagnosis is 71 years. Treatment options for NMSC include surgical therapy, which is usually the first-choice treatment, and nonsurgical modalities. Therapeutic modalities depend on tumor localization, histologic type, and biologic behavior, as well as patient comorbidities, age, and life expectancy. Read More

    Modification of therapeutic temperature range in cryotherapy could improve clinical efficacy in tension type headache.
    J Back Musculoskelet Rehabil 2018 Mar 9. Epub 2018 Mar 9.
    Biomedial Research Center, Korea University Anam Hospital, Seoul, Korea.
    Background: Cold pack therapy is not used frequently in clinics in spite of its effectiveness in clinical reports. Low compliance due to cold intolerance may be a disturbance factor that hinders patients from using the modality.

    Objective: To demonstrate the improved compliance and clinical efficacy as new devised cold modality with a different composition is applied to target different therapeutic temperature range in tension-type headache (TTH) patients. Read More

    Non-pharmacological interventions for restless legs syndrome: a systematic review of randomised controlled trials.
    Disabil Rehabil 2018 Mar 21:1-9. Epub 2018 Mar 21.
    a Department of Physiotherapy , Monash University , Frankston , Australia.
    Introduction: Restless legs syndrome (RLS) is a sensorimotor disorder characterised by an uncomfortable urge to move the legs. Management is primarily pharmacological. Effects for non-pharmacological, non-surgical options are published but lack systematic examination. Read More

    The Role of Protein Loss and Denaturation in Determining Outcomes of Heat, Cryotherapy and Irreversible Electroporation on Cardiomyocytes.
    J Biomech Eng 2018 Feb 17. Epub 2018 Feb 17.
    Department of Mechanical Engineering, University of Minnesota; Institute for Engineering in Medicine, University of Minnesota; Department of Biomedical Engineering, University of Minnesota, 111 Church St SE, Minneapolis, MN, 55455.
    Atrial fibrillation affects millions of people in the US. Focal therapy is an attractive treatment for atrial fibrillation that avoids the debilitating effects of drugs for disease control. Perhaps the most widely used focal therapy for atrial fibrillation (AF) is heat-based radiofrequency (heating), although cryotherapy (cryo) is rapidly replacing it due to a reduction in side effects and positive clinical outcomes. Read More

    Salvage image guided radiation therapy to the prostate after cryotherapy failure.
    Adv Radiat Oncol 2018 Jan-Mar;3(1):52-56. Epub 2017 Sep 27.
    Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.
    Purpose: Cryotherapy is an option for the primary treatment of localized prostate cancer, along with radical prostatectomy, external beam radiation therapy, and brachytherapy. Although it is known that local recurrence can occur in >20% of patients treated with primary cryotherapy, unfortunately there is a paucity of data on later salvage treatments. The use of external beam radiation therapy is an attractive option after cryotherapy failure, but there is little data on its efficacy and toxicity. Read More

    Delayed effects of a 20-min crushed ice application on knee joint position sense assessed by a functional task during a re-warming period.
    Gait Posture 2018 Mar 6;62:173-178. Epub 2018 Mar 6.
    Manchester Metropolitan University, Department of Health Professions, Manchester, Brooks Building, M15 6GX, United Kingdom.
    Delayed effects of a 20-min crushed ice application on knee joint position sense assessed by a functional task during a re-warming period.

    Introduction: The effect of cryotherapy on joint positioning presents conflicting debates as to whether individuals are at an increased risk of injury when returning to play following cryotherapy application at the lower limb.

    Objectives: The aim of this study was to investigate whether a 20 min application of crushed ice at the knee affects knee joint kinematics immediately post and up to 20 mins post ice removal, during a small knee bend. Read More

    A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception.
    J Vis Exp 2018 Mar 3(133). Epub 2018 Mar 3.
    Department of Physical Therapy, The College of St. Scholastica;
    Proprioception may be the least well measured of all contributors to the neural control of movement. New precise, reliable measures of proprioception are needed for clinical diagnosis of impairment, and to measure outcomes of proprioceptive training. The purpose of this simple, non-invasive method is to temporarily knockdown upper limb proprioception in healthy adults, to an extent that would be useful in the development and testing of upper limb proprioception measures. Read More

    [Salvage cryotherapy of prostate cancer after failed external radiotherapy and brachytherapy: Morbidity and mid-term oncological results].
    Prog Urol 2018 Apr 16;28(5):291-301. Epub 2018 Mar 16.
    Service d'urologie, groupe hospitalier Paris Saint-Joseph, 18, rue Raymond-Losserand, 75674 Paris cedex 14, France.
    Objective: To study the oncologic and functional results of salvage cryotherapy after failure of external radiotherapy and brachytherapy.

    Materials And Methods: Patients treated by total salvage cryotherapy (3rd generation) in 2 centers (Groupe Hospitalier Saint-Joseph in Paris and Clinique Jule-Verne Nantes) in between January 2008 and April 2016 were included. The biochemical recurrence-free survival (BRFS) was calculated using the Phoenix criteria (PSA>nadir+2ng/mL). Read More

    Analgesic effects of local anesthetic cream in cryotherapy for warts: a meta-analysis of randomized trials.
    J Dtsch Dermatol Ges 2018 Mar;16(3):307-311
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
    Background And Objective: Local anesthetic cream (LAC) has been used for analgesia in various procedures. However, the analgesic effect of LAC in cryotherapy for warts is unclear. We aimed to evaluate the effects of LAC in cryotherapy for warts. Read More

    Clinical Efficacy of Diphenylcyclopropenone Immunotherapy as Monotherapy for Multiple Viral Warts.
    J Cutan Med Surg 2018 Mar 1:1203475418764106. Epub 2018 Mar 1.
    1 Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.
    Background: Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy.

    Objectives: We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and pulsed dye laser (PDL) therapy. We also assessed the impact of initial sensitization on clinical response. Read More

    Cryotherapy and Radiofrequency Ablation for Eradication of Barrett's Esophagus with Dysplasia or Intramucosal Cancer.
    Dig Dis Sci 2018 May 9;63(5):1311-1319. Epub 2018 Mar 9.
    Center of Excellence for Barrett's Esophagus, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
    Background And Aims: Endoscopic ablation therapy has become the mainstay of treatment of Barrett's associated dysplasia and intramucosal cancer (IMC). The widely available techniques for ablation are radiofrequency ablation (RFA) and cryotherapy. Our aim was to compare eradication rates of metaplasia and dysplasia with both these modalities. Read More

    Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus.
    Gen Dent 2018 Mar-Apr;66(2):47-49
    The human papillomavirus (HPV) has an affinity for squamous cells of stratified keratinized epithelium, thus affecting the lower genital, nasal, and oral tracts. In the oral cavity, HPV is associated with pathoses such as the verruca vulgaris (common wart), squamous cell papilloma, condyloma acuminatum (venereal wart), and focal epithelial hyperplasia (Heck disease). Among the treatments available for these lesions are cryotherapy, electrosurgery, surgical removal, laser therapy, and trichloroacetic acid (TCA). Read More

    Therapeutic mild hypothermia improves early outcomes in rats subjected to severe sepsis.
    Life Sci 2018 Apr 2;199:1-9. Epub 2018 Mar 2.
    Department of Respiratory and Critical Care Medicine, Second Hospital of Zhejiang University School of Medicine. No. 88 Jiefang Road, Hangzhou, Zhejiang, China. Electronic address:
    Aims: Therapeutic hypothermia has shown beneficial effects in sepsis. This study focused on its mechanism.

    Main Methods: Sixteen male Sprague-Dawley rats underwent cecal ligation and perforation and subsequently were treated with either hypothermia (HT; body temperature cooled and maintained at 34 °C by ice pad for 10 h; n = 8) or normothermia (NT; n = 8). Read More

    Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
    Cochrane Database Syst Rev 2018 03 2;3:CD011893. Epub 2018 Mar 2.
    Department of Neonatology, University of Basel Children's Hospital (UKBB), Basel, Basel, Switzerland, CH-4031.
    Background: Retinopathy of prematurity (ROP) is a vision-threatening disease of preterm neonates. The use of beta-adrenergic blocking agents (beta-blockers), which modulate the vasoproliferative retinal process, may reduce the progression of ROP or even reverse established ROP.

    Objectives: To determine the effect of beta-blockers on short-term structural outcomes, long-term functional outcomes, and the need for additional treatment, when used either as prophylaxis in preterm infants without ROP, stage 1 ROP (zone I), or stage 2 ROP (zone II) without plus disease or as treatment in preterm infants with at least prethreshold ROP. Read More

    Nursing Theory, Terminology, and Big Data: Data-Driven Discovery of Novel Patterns in Archival Randomized Clinical Trial Data.
    Nurs Res 2018 Mar/Apr;67(2):122-132
    Karen A. Monsen, PhD, RN, FAAN, is Associate Professor, School of Nursing, University of Minnesota, Minneapolis. Teresa J. Kelechi, PhD, RN, FAAN, is Professor, College of Nursing, Medical University of South Carolina, Charleston. Marion E. McRae, MScN, ACNP-BC, Robert Wood Johnson Foundation Future of Nursing Scholar, is Nurse Practitioner Nurse Practitioner-Coronary Care Unit, Ronald Reagan UCLA Medical Center, Los Angeles, California. Michelle A. Mathiason, MS, is Statistician, School of Nursing, University of Minnesota, Minneapolis. Karen S. Martin, MSN, RN, FAAN, is Consultant, Martin Associates, Omaha, Nebraska.
    Background: The growth and diversification of nursing theory, nursing terminology, and nursing data enable a convergence of theory- and data-driven discovery in the era of big data research. Existing datasets can be viewed through theoretical and terminology perspectives using visualization techniques in order to reveal new patterns and generate hypotheses. The Omaha System is a standardized terminology and metamodel that makes explicit the theoretical perspective of the nursing discipline and enables terminology-theory testing research. Read More

    Innovative approaches to cervical cancer screening in low- and middle-income countries.
    Climacteric 2018 Feb 28:1-4. Epub 2018 Feb 28.
    a Sexual and Reproductive Health Unit , Papua New Guinea Institute of Medical Research , Goroka , Papua New Guinea.
    The estimated cervical cancer burden is over ten-fold greater in low- and middle-income countries (LMICs) than in high-income countries. This health gap is thought to be primarily due to limited access to effective screening and treatment programs for cervical pre-cancer and cancer in such settings. The World Health Organization advocates a policy of 'screen and treat' approach to cervical screening in LMICs and subsequently visual inspection of the cervix with acetic acid (VIA) or Lugo's iodine (VILI), followed by ablative cervical cryotherapy if indicated, and this policy has been implemented in many high-burden settings. Read More

    A survey of flexible bronchoscopy practices in India: The Indian bronchoscopy survey (2017).
    Lung India 2018 Mar-Apr;35(2):98-107
    Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
    Background: There is a lack of contemporaneous data on the practices of flexible bronchoscopy in India.

    Aim: The aim of the study was to study the prevalent practices of flexible bronchoscopy across India.

    Methods: The "Indian Bronchoscopy Survey" was a 98-question, online survey structured into the following sections: general information, patient preparation and monitoring, sedation and topical anesthesia, procedural/technical aspects, and bronchoscope disinfection/staff protection. Read More

    Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors.
    Mediators Inflamm 2018 1;2018:8592532. Epub 2018 Feb 1.
    School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Medicine, Angiology and Physical Medicine, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
    Objective: The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS).

    Material And Methods: We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. Read More

    In vivo optoacoustic temperature imaging for image-guided cryotherapy of prostate cancer.
    Phys Med Biol 2018 Mar 21;63(6):064002. Epub 2018 Mar 21.
    Tomowave Laboratories, Inc., 6550 Mapleridge St, Ste 124, Houston, TX 77081-4629, United States of America. Present address: Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States of America.
    The objective of this study is to demonstrate in vivo the feasibility of optoacoustic temperature imaging during cryotherapy of prostate cancer. We developed a preclinical prototype optoacoustic temperature imager that included pulsed optical excitation at a wavelength of 805 nm, a modified clinical transrectal ultrasound probe, a parallel data acquisition system, image processing and visualization software. Cryotherapy of a canine prostate was performed in vivo using a commercial clinical system, Cryocare CS, with an integrated ultrasound imaging. Read More

    Dose Escalation of Vitamin D Yields Similar Cryosurgical Outcome to Single Dose Exposure in a Prostate Cancer Model.
    Cancer Control 2018 Jan-Mar;25(1):1073274818757418
    1 Department of Biological Sciences, State University of New York at Binghamton, Binghamton, NY, USA.
    Vitamin D (VD) is an effective adjunctive agent, enhancing the destructive effects of freezing in prostate cancer cryoablation studies. We investigated whether dose escalation of VD over several weeks, to model the increase in physiological VD levels if an oral supplement were prescribed, would be as or more effective than a single treatment 1 to 2 days prior to freezing. PC-3 cells in log phase growth to model aggressive, highly metabolically active prostate cancer were exposed to a gradually increasing dose of VD to a final dose of 80 nM over a 4-week period, maintained for 2 weeks at 80 nM, and then exposed to mild sublethal freezing temperatures. Read More

    Cryotherapy for persistent Barrett's esophagus after radiofrequency ablation: a systematic review and meta-analysis.
    Gastrointest Endosc 2018 Feb 21. Epub 2018 Feb 21.
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address:
    Background And Aims: A small but significant proportion of patients with Barrett's esophagus (BE) have persistent dysplasia or intestinal metaplasia (IM) after treatment with radiofrequency ablation (RFA). Cryotherapy is a cold-based ablative modality that is increasingly being used in this setting. We aimed to better understand the efficacy of second-line cryotherapy in BE patients with persistent dysplasia or IM after RFA by conducting a systematic review and meta-analysis. Read More

    Irreversible Electroporation for Prostate Cancer as Salvage Treatment Following Prior Radiation and Cryotherapy.
    Rev Urol 2017 ;19(4):268-272
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterNew York, NY.
    Salvage treatment options after localized primary treatment failure of prostate cancer are limited and associated with risk for serious complications. We report on the management details of a 57-year-old African American man treated with partial-gland ablation using irreversible electroporation following local recurrence after brachytherapy and prior salvage cryoablation. Therapeutic and functional outcomes were assessed by conventional means, including serum prostate-specific antigen values and prostate biopsy results. Read More

    Cooling of the oral mucosa to prevent adverse effects of chemotherapeutic agents: An in vitro study.
    J Oral Pathol Med 2018 Feb 22. Epub 2018 Feb 22.
    School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
    Background: The cytotoxic effect of chemotherapeutic agents to the oral mucosa, as a side effect of cancer treatment, is a major problem. Cooling the oral mucosa using ice chips in conjunction with chemotherapy is known to reduce the severity of oral mucositis. However, although the use of ice chips is of clinical value, this method of cooling has inherent problems including discomfort for the patient, non-uniformity and fluctuations in cooling temperature throughout the oral cavity. Read More

    Precooling and Warm-Up Effects on Time Trial Cycling During Heat Stress.
    Aerosp Med Hum Perform 2018 Feb;89(2):87-93
    University of Alabama, Tuscaloosa, AL, USA.
    Background: Heat stress limits endurance exercise performance. Combining precooling and warm-up prior to endurance exercise in the heat may exploit the benefits of both strategies while avoiding the potential negative consequences of each. This study tested the hypothesis that precooling combined with warm-up improves time trial cycling performance in the heat relative to either treatment alone. Read More

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