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    1 OF 557

    [Ethyl chloride aerosol spray for local anesthesia before arterial puncture: randomized placebo-controlled trial].
    Emergencias 2017 Jun;29(3):161-166
    Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Leioa, España. Unidad de Cuidados Intensivos, Hospital de Gallakao-Usánsolo, Galdakao, España.
    Objectives: To compare the efficacy of an ethyl chloride aerosol spray to a placebo spray applied in the emergency department to the skin to reduce pain from arterial puncture for blood gas analysis.

    Material And Methods: Single-blind, randomized placebo-controlled trial in an emergency department of Hospital de Basurto in Bilbao, Spain. We included 126 patients for whom arterial blood gas analysis had been ordered. Read More

    Partial gland ablation versus radical prostatectomy Comparative Analysis of Partial Gland Ablation and Radical Prostatectomy to Treat Low- and Intermediate-risk Prostate Cancer: Oncologic and Functional Outcomes.
    J Urol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Urology, Institut Mutualiste Montsouris, Université Paris-Descartes, Paris, France.
    Purpose: To analyze oncologic and functional outcomes of partial gland ablation (PGA) compared with robot-assisted radical prostatectomy (RARP) for patients with low-and intermediate-risk prostate cancer.

    Material And Methods: From July 2009 to September 2015, 1883 patients underwent RARP and 373 had PGA. From those, we selected 1458 participants (1222 RARP and 236 PGA) who have Gleason score 3+3 or 3+4, clinical stage ≤T2b, prostate-specific antigen(PSA) ≤15ng/dl, unilateral disease and life expectancy >10 years. Read More

    Ablation Therapy for Barrett's Esophagus: New Rules for Changing Times.
    Curr Gastroenterol Rep 2017 Aug 17;19(10):48. Epub 2017 Aug 17.
    Department of Internal Medicine, University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, MI, USA.
    Purpose Of Review: In this review, we discuss different endoscopic techniques in the eradication of Barrett's esophagus (BE) as well as some controversies in the field of treatment.

    Recent Findings: Patients with T1a esophageal adenocarcinoma and BE of high-grade dysplasia should undergo endoscopic ablative therapy. The most studied technique to date is radiofrequency ablation. Read More

    Cryotherapy versus high-intensity focused ultrasound for treating prostate cancer: Oncological and functional results.
    Actas Urol Esp 2017 Aug 14. Epub 2017 Aug 14.
    Departamento de Urología, Hospital Ramón y Cajal, Madrid, España.
    Context And Objective: The increasingly early diagnosis of prostate cancer requires a search for therapeutic alternatives with good oncological results that in turn facilitate a good long-term quality of life. This review analyses 2 minimally invasive therapies for treating localised prostate cancer in terms of oncological and functional results, as well as the complications resulting from the therapies.

    Acquisition Of Evidence: A systematic literature review was conducted of the treatment of localised prostate cancer with 2 ablative techniques as the primary therapy: cryosurgery or cryotherapy and high intensity focused ultrasound (HIFU). Read More

    Drug-Free Interventions to Reduce Pain or Opioid Consumption After Total Knee Arthroplasty: A Systematic Review and Meta-analysis.
    JAMA Surg 2017 Aug 16:e172872. Epub 2017 Aug 16.
    Department of Medicine, Stanford University, Stanford, California.
    Importance: There is increased interest in nonpharmacological treatments to reduce pain after total knee arthroplasty. Yet, little consensus supports the effectiveness of these interventions.

    Objective: To systematically review and meta-analyze evidence of nonpharmacological interventions for postoperative pain management after total knee arthroplasty. Read More

    Cryotherapy Treatment After Unicompartmental and Total Knee Arthroplasty: A Review.
    J Arthroplasty 2017 Jul 21. Epub 2017 Jul 21.
    Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
    Background: Cryotherapy is widely utilized to enhance recovery after knee surgeries. However, the outcome parameters often vary between studies. Therefore, the purpose of this review is to compare (1) no cryotherapy vs cryotherapy; (2) cold pack cryotherapy vs continuous flow device cryotherapy; (3) various protocols of application of these cryotherapy methods; and (4) cost-benefit analysis in patients who had unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA). Read More

    Cellular Blue Nevus of Perilimbal Conjunctiva: A Case Report and Review of Literature.
    Ann Clin Lab Sci 2017 Aug;47(4):477-480
    Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin China.
    Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Read More

    Cryosurgical posterior nasal tissue ablation for the treatment of rhinitis.
    Int Forum Allergy Rhinol 2017 Aug 11. Epub 2017 Aug 11.
    San Francisco Otolaryngology, San Francisco, CA.
    Background: Endoscopic posterior nasal nerve (PNN) resection has been described as an efficacious surgical treatment of allergic and nonallergic rhinitis, but the requirement for surgery under general anesthesia has limited its acceptance. We report the first series of patients treated for chronic rhinitis using a novel device designed for office-based cryosurgical ablation of the PNN.

    Methods: Twenty-seven patients with chronic rhinorrhea and/or nasal congestion for >3 months were recruited (allergic or nonallergic rhinitis), with minimum rhinorrhea and/or congestion subscores of 2 as part of the Total Nasal Symptom Score [TNSS]). Read More

    Ice formation on kaolinite: Insights from molecular dynamics simulations.
    J Chem Phys 2016 Dec;145(21):211927
    Thomas Young Centre, London Centre for Nanotechnology and Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, United Kingdom.
    The formation of ice affects many aspects of our everyday life as well as important technologies such as cryotherapy and cryopreservation. Foreign substances almost always aid water freezing through heterogeneous ice nucleation, but the molecular details of this process remain largely unknown. In fact, insight into the microscopic mechanism of ice formation on different substrates is difficult to obtain even if state-of-the-art experimental techniques are used. Read More

    Surgical excision of a feline orbital lacrimal gland adenocarcinoma with adjunctive cryotherapy and carboplatin-impregnated bead implantation.
    Vet Ophthalmol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, 1008 W. Hazelwood Drive, Urbana, IL, 61802, USA.
    The purpose of this report was to discuss the diagnosis, treatment, and outcome of a cat with an orbital lacrimal gland adenocarcinoma. A 14.5-year-old spayed female domestic shorthair cat was evaluated for a firm swelling at the left dorsotemporal orbital rim. Read More

    Clinical, epidemiological, and therapeutic profile of patients with a retinoblastoma diagnosis experience in the Costa Rica National Children's Hospital Oncology Unit from January 2009 to December 2015.
    Ecancermedicalscience 2017 24;11:754. Epub 2017 Jul 24.
    Radiation Therapy Unit, Department of Hematology-Oncology, Mexico Hospital, CCSS, San José, Costa Rica.
    Introduction: Retinoblastoma represents only 3% of paediatric cancers, but it is the most prevalent intraocular tumour in this population. It develops in the retina as a primitive neuroectodermal tumour that affects development during gestation. The tumour presents in two different forms depending on whether or not it expresses a genetic modification. Read More

    Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer.
    Transl Androl Urol 2017 Jul;6(Suppl 2):S92-S102
    Department of Urology, Concord Repatriation General Hospital, Concord, University of Sydney, Australia.
    The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment. Read More

    Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach.
    Open Access Maced J Med Sci 2017 Jul 21;5(4):545-546. Epub 2017 Jul 21.
    "Onkoderma" - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria.
    A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. Read More

    Outcome of focal treatment to residual retinoblastoma after chemotherapy (Experience with Focal Treatment of Retinoblastoma).
    J Pak Med Assoc 2017 Jul;67(7):1109-1115
    Professor (Rtd) of Ophthalmology at Dow University of Health Sciences and Civil Hospital, Karachi..
    We report a prospective case series on the anatomical, and functional outcomes, and complications of focal treatment of retinoblastoma to residual tumors in patients who had already received chemotherapy. We examined the patients of retinoblastoma under general anaesthesia with Ret Cam II. Patients with lesions from Group 1 to Group 5 of Reese Ellsworth classification at presentation. Read More

    Efficacy Of Liquid Nitrogen Cryotherapy for Barrett's Esophagus After Endoscopic Resection of Intramucosal Cancer: A Multicenter Study.
    J Gastroenterol Hepatol 2017 Aug 2. Epub 2017 Aug 2.
    University of Rochester Medical Center, Strong Memorial Hospital, Rochester, NY.
    Background And Aim: Liquid nitrogen cryotherapy (LNC) allows increased depth of ablation compared to radiofrequency ablation (RFA) in Barrett's esophagus (BE). Expert centers may use LNC over RFA to ablate Barrett's esophagus after endoscopic resection of intramucosal cancer (IMCA). The aim of our study was to: 1) evaluate the safety and efficacy of LNC ablation in patients with BE and IMCA and 2) to evaluate the progression to invasive disease despite therapy. Read More

    Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6 / IL-17 pathway but independently of TNFα.
    PLoS One 2017 31;12(7):e0178668. Epub 2017 Jul 31.
    PEPITE EA4267, FHU INCREASE, Univ. Bourgogne Franche-Comté, Besançon, France.
    Objectives: Local cryotherapy is widely and empirically used in the adjuvant setting in rheumatoid arthritis treatment, however its own therapeutic and anti-inflammatory effects are poorly characterized. We aimed to evaluate the effects of local cryotherapy on local and systemic inflammation in Adjuvant-induced arthritis, a murine model of rheumatoid arthritis.

    Methods: The effects of mild hypothermia (30°C for 2 hours) on cytokine protein levels (Multiplex/ELISA) were evaluated in vitro in cultured rat adjuvant-induced arthritis patellae. Read More

    Management outcome(s) in eyes with retinoblastoma previously inadequately treated with systemic chemotherapy alone without focal therapy.
    Oman J Ophthalmol 2017 May-Aug;10(2):70-75
    Department of Surgery, King Hussein Cancer Center, Amman, Jordan.
    Objective: The objective of this study was to evaluate the outcome of management in eyes with intraocular retinoblastoma (RB) that had received inadequate initial therapy (chemotherapy without focal therapy) before eventually receiving necessary consolidation therapy at a tertiary referral center.

    Methods: A retrospective observational case series of 30 eyes from 26 RB patients who had initially received systemic chemotherapy as a sole therapy. The main outcome measures were demographics, laterality, International Classification of RB (ICRB), treatments, tumor control, and survival. Read More


    Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
    JAMA 2017 Jul;318(4):341-350
    Division of Intensive Care, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland20Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University Melbourne, Australia.
    Importance: International resuscitation guidelines recommend targeted temperature management (TTM) at 33°C to 36°C in unconscious patients with out-of-hospital cardiac arrest for at least 24 hours, but the optimal duration of TTM is uncertain.

    Objective: To determine whether TTM at 33°C for 48 hours results in better neurologic outcomes compared with currently recommended, standard, 24-hour TTM.

    Design, Setting, And Participants: This was an international, investigator-initiated, blinded-outcome-assessor, parallel, pragmatic, multicenter, randomized clinical superiority trial in 10 intensive care units (ICUs) at 10 university hospitals in 6 European countries. Read More

    Infections causing central airway obstruction: role of bronchoscopy in diagnosis and management.
    J Thorac Dis 2017 Jun;9(6):1707-1724
    Section of Interventional Pulmonology, Division of Pulmonary Critical Care and Sleep, Department of Medicine, Westchester Medical Center, Valhalla, New York, USA.
    Central airway obstructive infections (CAOI) are challenging medical conditions that may represent an advanced and complicated process of ongoing infections. The epidemiology of CAOI is unknown as well as the pathophysiology and the mechanism of development. This is due to sparse data in the literature that consists mainly of case reports and retrospective case series. Read More

    Effect of Whole-Body Cryotherapy on Antioxidant Systems in Experimental Rat Model.
    Oxid Med Cell Longev 2017 27;2017:8158702. Epub 2017 Jun 27.
    Department of Physiology, School of Medicine in Zabrze, Medical University of Silesia, Katowice, Poland.
    Background: The purpose of this study was to verify the effect of whole-body cryotherapy (WBC) in rats on their antioxidant systems, lipid peroxidation products, and their total oxidative status at different exposure times and temperatures.

    Methods: Antioxidants in serum, plasma, liver, and erythrocytes were evaluated in two study groups following 1 min of exposure to -60°C and -90°C, for 5 and 10 consecutive days.

    Results: WBC increased the activity of superoxide dismutase, catalase in the group subjected to 5 and 10 days exposure, -60°C. Read More

    Scalp Cooling: The Prevention of Chemotherapy-Induced Alopecia
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    Clin J Oncol Nurs 2017 Aug;21(4):413-415
    CancerCare Manitoba.
    Hair loss (alopecia) from chemotherapy is one of the most feared side effects of many patients, particularly women. Many patients and their healthcare providers believe that cryotherapy can help prevent or mitigate these changes. Scalp cooling has been used for more than 30 years to prevent alopecia caused by chemotherapy, particularly taxanes and anthracyclines. Read More

    The Role of Therapeutic Modalities in Surgical and Nonsurgical Management of Orthopaedic Injuries.
    J Am Acad Orthop Surg 2017 Aug;25(8):556-568
    From the Steadman Philippon Research Institute, Vail, CO.
    Rehabilitation professionals often use therapeutic modalities as a component of the surgical and nonsurgical management of orthopaedic injuries. Myriad therapeutic modalities, including cryotherapy, thermotherapy, ultrasonography, electrical stimulation, iontophoresis, and laser therapy, are available. Knowledge of the scientific basis of each modality and the principles of implementation for specific injuries enables musculoskeletal treatment providers to prescribe these modalities effectively. Read More

    Should adjuvant irradiation to prevent keloidal fibroproliferative growth, be standard of care?
    Br J Dermatol 2017 Jul 21. Epub 2017 Jul 21.
    Radiation Oncology, State University of New York Downstate Medical Center, Brooklyn, NY.
    After cutaneous injury, cytokine mediators recruit an inflammatory infiltrate that stimulates migration of keratinocytes and fibroblasts; subsequent proliferation of fibroblasts and keratinocytes begins 4 to 5 days later [1]. The formation of a keloid is dependent upon fibroblast migration, proliferation and type III collagen production [1]. First{\hyphen}line treatment of keloids involves topical or intralesional steroids. Read More

    Focal cryotherapy: step by step technique description.
    Int Braz J Urol 2017 Jul 20;43. Epub 2017 Jul 20.
    L'Institut Mutualiste Montsouris - Urology, Paris, France.
    Introduction And Objective: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa). The purpose of this video is to describe the procedure step by step.

    Materials And Methods: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. Read More

    Cost-effectiveness of cervical cancer screening and preventative cryotherapy at an HIV treatment clinic in Kenya.
    Cost Eff Resour Alloc 2017 14;15:13. Epub 2017 Jul 14.
    Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104 USA.
    Objective: This study evaluated the potential cost-effectiveness of cervical cancer screening in HIV treatment clinics in Nairobi, Kenya.

    Methods: A Markov model was used to project health outcomes and costs of cervical cancer screening and cryotherapy at an HIV clinic in Kenya using cryotherapy without screening, visual inspection with acetic acid (VIA), Papanicolaou smear (Pap), and testing for human papillomavirus (HPV). Direct and indirect medical and non-medical costs were examined from societal and clinic perspectives. Read More

    Evidence base and practice variation in acute care processes for knee and hip arthroplasty surgeries.
    PLoS One 2017 19;12(7):e0180090. Epub 2017 Jul 19.
    South Western Sydney Clinical School, UNSW, Randwick, Australia.
    Background: Lack of evidence contributes to unnecessary variation in treatment costs and outcomes. This study aimed to identify from interventions historically used for total knee or hip arthroplasty (TKA, THA): i) if routine use is supported by high-level evidence; ii) whether surgeon use aligns with the evidence.

    Methods: Part 1: Systematic search of electronic library databases for systematic reviews and practice guidelines concerning seven acute-care interventions. Read More

    Comparative Oncologic and Toxicity Outcomes of Salvage Radical Prostatectomy Versus Nonsurgical Therapies for Radiorecurrent Prostate Cancer: A Meta-Regression Analysis.
    Eur Urol Focus 2016 Jun 4;2(2):158-171. Epub 2015 Oct 4.
    Department of Urology, Addenbrooke's University Hospital, Cambridge, UK; Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:
    Context: In the absence of randomised controlled trials comparing the oncologic, toxicity, and functional outcomes of salvage radical prostatectomy (SRP), salvage high-intensity focused ultrasound (SHIFU), salvage brachytherapy (SBT), and salvage cryotherapy (SCT), controversy exists as to the optimal salvage modality in radiorecurrent prostate cancer.

    Objective: We carried out a meta-regression analysis to determine whether there is a difference in oncologic, toxicity, and functional outcomes using data from original publications of salvage modalities in the postradiation setting.

    Evidence Acquisition: We performed a systematic review of PubMed/Medline citations according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. Read More

    Persistent papilloma treated with cryotherapy in three dogs.
    Vet Dermatol 2017 Jul 18. Epub 2017 Jul 18.
    Animal Dermatology Clinic, 2965 Edinger Ave, Tustin, CA, 92780, USA.
    Background: Canine papillomaviruses can affect the mucous membranes and skin of young, old and immunocompromised dogs. Most lesions regress spontaneously over a four to eight week interval; however, in some cases the lesions may persist or progress. Cryotherapy is used as a treatment for papillomavirus induced lesions in veterinary practice but there is limited published evidence regarding its use. Read More

    Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system (with video).
    Gastrointest Endosc 2017 Jul 15. Epub 2017 Jul 15.
    Digestive and Liver Disease, Columbia University Medical Center, New York.
    Background And Aims: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or radiofrequency ablation (RFA). A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system (CbFAS) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon. Read More

    A Computerized Tutor Prototype for Prostate Cryotherapy: Key Building Blocks and System Evaluation.
    Proc SPIE Int Soc Opt Eng 2017 Jan 22;10066. Epub 2017 Feb 22.
    Department of General Surgery, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212.
    This paper focuses on the evaluation of a prototype for a computer-based tutoring system for prostate cryosurgery, while reviewing its key building blocks and their benchmark performance. The tutoring system lists geometrical constraints of cryoprobe placement, displays a rendered shape of the prostate, simulates cryoprobe insertion, enables distance measurements, simulates the corresponding thermal history, and evaluates the mismatch between the target region shape and a pre-selected planning isotherm. The quality of trainee planning is measured in comparison with a computer-generated plan, created for each case study by a previously developed planning algorithm, known as bubble-packing. Read More

    [The influence of pain aliments and vertebral mobility in patients after whole body cryotherapy].
    Wiad Lek 2017 ;70(3 pt 2):543-546
    Wydział Lekarski Z Oddziałem Lekarsko-Dentystycznym W Zabrzu Katedra I Oddział Kliniczny Chorob Wewnętrznych, Angiologii i Medycyny Fizykalnej Oraz Ośrodek Diagnostyki i Terapii Laserowej, Śląski Uniwersytet Medyczny, Katowice, Polska.
    Introduction: The motive efficiency depends from many factors, in this currently also form the state of health. The change in grounds of vertebral column causing the limitations of mobility and pain can significance worsen the functional state, motive efficiency and quality of patient's life. The leadership of active mode of life complying to recommendations the preventive style of life as well as the using with interventions of physical medicine influences on improvement significance the state of health. Read More

    The Cost-Effectiveness of Visual Triage of Human Papillomavirus-Positive Women in Three Low- and Middle-Income Countries.
    Cancer Epidemiol Biomarkers Prev 2017 Jul 14. Epub 2017 Jul 14.
    Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health.
    Background: World Health guidelines support HPV testing alone (followed by treatment with cryotherapy) or in conjunction with visual inspection with acetic acid (VIA) triage testing. Our objective was to determine the cost-effectiveness of VIA triage for HPV-positive women in low-resource settings.

    Methods: We calibrated mathematical simulation models of HPV infection and cervical cancer to epidemiologic data from India, Nicaragua, and Uganda. Read More

    Dysglycemia, Glycemic Variability, and Outcome After Cardiac Arrest and Temperature Management at 33°C and 36°C.
    Crit Care Med 2017 Aug;45(8):1337-1343
    1Department of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden.2Department of Clinical Sciences, Lund University, Lund, Sweden.3Adult Critical Care, University Hospital of Wales, Cardiff, United Kingdom.4Department of Anaesthesia and Intensive Care, Intensive Care Unit, Helsingborg Hospital, Sweden.5Cardiothoracic Intensive Care Unit, St. George's Hospital NHS Foundation Trust, London, United Kingdom.6Department of Intensive Care, Royal Bournemouth Hospital, Bournemouth, United Kingdom.7Department of Neurology, Skåne University Hospital, Lund, Sweden.8Department of Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.9Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.10Department of Intensive Care, Medical Center Leeuwarden, Leeuwarden, the Netherlands.11Department of Cardiology and Angiology, General University Hospital in Prague, Prague, Czech Republic.12Department of Intensive Care, Royal Berkshire Hospital, Reading, United Kingdom.
    Objectives: Dysglycemia and glycemic variability are associated with poor outcomes in critically ill patients. Targeted temperature management alters blood glucose homeostasis. We investigated the association between blood glucose concentrations and glycemic variability and the neurologic outcomes of patients randomized to targeted temperature management at 33°C or 36°C after cardiac arrest. Read More

    The effect of cryotherapy on total antioxidative capacity in patients with active seropositive rheumatoid arthritis.
    Rheumatol Int 2017 Jul 11. Epub 2017 Jul 11.
    Department of Rheumatology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    Patients with rheumatoid arthritis (RA) have increased oxidative stress, decreased antioxidant levels, and impaired antioxidant capacity. Cold treatments are used to relieve joint inflammation and pain. Therefore, we measured the effect of cold treatments on the antioxidative capacity of RA patients with active disease. Read More

    Treatment of Annular Elastolytic Giant Cell Granuloma With Topical Tretinoin.
    J Drugs Dermatol 2017 Jul;16(7):699-700

    Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy. Read More


    Cryotherapy Treatment After Arthroscopic Knee Debridement and ACL Reconstruction: A Review.
    Surg Technol Int 2017 Jul;30:415-424
    Department of Orthopaedic Surgery, Cleveland Clinic, Ohio, Cleveland, Ohio.
    Pain, swelling, and inflammation of the knee joint and its surrounding soft-tissue structures are common during the postoperative period after arthroscopic knee debridement and anterior cruciate ligament reconstruction. These challenges can make patient recovery difficult immediately after surgery. Several options exist, however, to help patients overcome these challenges. Read More

    Cryotherapy for Intra- and Perianal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men who have Sex with Men.
    Am J Clin Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Center for Infection and Immunology Amsterdam (CINIMA), Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands.
    Background: Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders.

    Methods: This retrospective, non-randomized study included HIV-positive MSM who received intra- and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015. Read More

    [Effect on cryoablation of high-risk and locally recurrent prostate cancer: a Meta-analysis].
    Zhonghua Yi Xue Za Zhi 2017 Jul;97(25):1975-1980
    Department of Ultrasound, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
    Objective: To discuss the curative effect and prognosis of cryoablation to high-risk and locally recurrent prostate cancer patients. Methods: Cryoablation related publications and relevant references were searched for potential pertinent articles until March, 2016.Articles were selected according to the exclusion criteria, Stata ver. Read More

    The use of lasers in the treatment of skin cancer: A review.
    J Cosmet Laser Ther 2017 Jul 10:1-8. Epub 2017 Jul 10.
    c Skin and Laser Surgery Center of New England , Nashua , NH , USA.
    Background: In considering skin cancer, a number of factors-including effectiveness, simplicity of treatment, cost, and esthetic outcomes-are important to ensure patient's satisfaction. There are several existing interventions, such as electrodessication and curettage, excision, Mohs surgery, radiation therapy, cryotherapy, and topical/oral treatments. Laser therapy has emerged as a new promising alternative that should be explored. Read More

    Management algorithms for cervical cancer screening and precancer treatment for resource-limited settings.
    Int J Gynaecol Obstet 2017 Jul;138 Suppl 1:26-32
    Screening Group, Early Detection and Prevention Section, International Agency for Research on Cancer, Lyon, France.
    Management algorithms for screen-positive women in cervical cancer prevention programs have undergone substantial changes in recent years. The WHO strongly recommends human papillomavirus (HPV) testing for primary screening, if affordable, or if not, then visual inspection with acetic acid (VIA), and promotes treatment directly following screening through the screen-and-treat approach (one or two clinic visits). While VIA-positive women can be offered immediate ablative treatment based on certain eligibility criteria, HPV-positive women need to undergo subsequent VIA to determine their eligibility. Read More

    Treatment of cervical intraepithelial lesions.
    Int J Gynaecol Obstet 2017 Jul;138 Suppl 1:20-25
    Edinburgh University, Edinburgh, UK.
    Precancerous cervical lesions precede the development of invasive cervical cancer by 10-20 years, making cervical cancer preventable if these lesions are detected and effectively treated. Treatment has evolved in the last few decades and now includes ablative options that can be performed in lower-resource settings where surgical excision is not feasible or routinely available. Gas-based cryotherapy, which freezes cervical tissue to induce localized necrosis, is the most commonly used ablative treatment. Read More

    Salvage Therapy Options for Local Prostate Cancer Recurrence After Primary Radiotherapy: a Literature Review.
    Curr Urol Rep 2017 Aug;18(8):63
    Winthrop University Hospital, Mineola, NY, USA.
    Purpose Of Review: While recurrence after primary treatment of prostate cancer (PCa) is not uncommon, there is currently no consensus on the most appropriate management after radiation treatment failure. This article seeks to explore the currently utilized modalities for salvage treatment for radiorecurrent PCa. We focused our review on the oncologic outcomes and reported toxicity rates in the latest studies examining salvage radical prostatectomy (SRP), salvage cryotherapy (SCT), salvage high-intensity focused ultrasound (HIFU) and re-irradiation. Read More

    The impact of incontinence etiology on artificial urinary sphincter outcomes.
    Investig Clin Urol 2017 Jul 27;58(4):241-246. Epub 2017 Jun 27.
    Department of Urology, Mayo Clinic, Rochester, MN, USA.
    Purpose: To evaluate the impact of incontinence etiology on artificial urinary sphincter (AUS) device outcomes.

    Materials And Methods: We identified 925 patients who underwent primary AUS placement from 1983 to 2011. The etiology of incontinence was categorized as radical prostatectomy alone, radical prostatectomy with radiation, benign prostate resection, and those with cryotherapy as a salvage prostate cancer treatment. Read More

    Cold-water immersion following sprint interval training does not alter endurance signaling pathways or training adaptations in human skeletal muscle.
    Am J Physiol Regul Integr Comp Physiol 2017 Jul 5:ajpregu.00434.2016. Epub 2017 Jul 5.
    Victoria University.
    We investigated the underlying molecular mechanisms by which post-exercise cold-water immersion (CWI) may alter key markers of mitochondrial biogenesis following both a single session and six weeks of sprint interval training (SIT). Nineteen males performed a single SIT session, followed by one of two 15-min recovery conditions: cold-water immersion (COLD; 10°C) or a passive room-temperature control (CON; 23°C). Sixteen of these participants also completed six weeks SIT, each session followed immediately by their designated recovery condition. Read More

    Cryotherapy for low risk prostate cancer, oncological and functional medium term outcomes: A three center prospective study.
    Arch Ital Urol Androl 2017 Jun 30;89(2):97-101. Epub 2017 Jun 30.
    Clinical Institute of Urology and Renal Transplants, Cluj-Napoca.
    Objectives: Analyze the oncologic and functional outcomes in patients affected by low risk prostate cancer underwent prostate cryotherapy. Materiasl and methods: It's a prospective tricentric study of 434 patients treated with prostate cryoablation for low risk prostate cancer. By low risk we refer to the D'Amico's risk classification. Read More

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