4,946 results match your criteria Cryoglobulinemia


A Case of Hepatitis C Related Mixed Cryoglobulinemia Syndrome.

J Community Hosp Intern Med Perspect 2022 12;12(2):53-56. Epub 2022 Apr 12.

Department of Internal Medicine, Trinitas Regional Medical Center, Elizabeth, New Jersey, USA.

Hepatitis C virus (HCV) is an RNA virus that preferentially infects hepatocytes and is transmitted through infected blood contact. Chronic hepatitis C can result in serious life-threatening conditions like fibrosis, cirrhosis, and liver cancer. Additionally, it can result in extrahepatic conditions including lymphoproliferative disease and mixed cryoglobulinemic vasculitis. Read More

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Clinicopathological Spectrum of Cryoglobulinemic Glomerulonephritis without Evidence of Autoimmunity Disorders: A Retrospective Study from a Single Institute of China.

Kidney Dis (Basel) 2022 May 25;8(3):253-263. Epub 2022 Mar 25.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Renal Pathology Center, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.

Background: Cryoglobulinemic glomerulonephritis (Cryo-GN), caused by circulating cryoglobulins, has varied etiology and clinical-pathologic manifestations. This study aimed to investigate the clinicopathological spectrum and outcome of patients with various Cryo-GN in China.

Methods: A retrospective review of 74 Chinese patients with biopsy-proven cryoglobulin-related renal lesions in Peking University First Hospital from 2010 to 2020 was performed. Read More

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[Splenic lymphoma, diagnosis and treatment].

Rev Med Interne 2022 Jun 9. Epub 2022 Jun 9.

Service d'hématologie clinique, hôpital Pitié-Salpêtrière, Sorbonne université, Assistance publique-Hôpitaux de Paris, 75013 Paris, France.

Some common clinical situations, such as splenomegaly or lymphocytosis, or less common, such as autoimmune hemolytic anemia, cold agglutinin disease, or cryoglobulinemia can lead to the diagnosis of splenic lymphoma. Splenic lymphoma is rare, mainly of non-hodgkinian origin, encompassing very different hematological entities in their clinical and biological presentation from an aggressive form such as hepato-splenic lymphoma to indolent B-cell lymphoma not requiring treatment such as marginal zone lymphoma, the most frequent form of splenic lymphoma. These entities can be challenging to diagnose and differentiate. Read More

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Relapse of cryoglobulinemic vasculitis with new-onset severe renal involvement in two patients following mRNA COVID-19 vaccination: A case report.

Medicine (Baltimore) 2022 Jun 10;101(23):e29431. Epub 2022 Jun 10.

Department of Nephrology, Fundeni Clinical Institute, Bucharest, Romania.

Rationale: Since mass-scale severe acute respiratory syndrome coronavirus 2 vaccination, there have been case reports of several immune-mediated reactions, including new-onset and flares of glomerular disorders following immunization with mRNA coronavirus disease 2019 vaccines. Here, we report two cases, the first to our knowledge, of relapsing cryoglobulinemic vasculitis with new-onset severe renal involvement following mRNA coronavirus disease 2019 vaccination.

Patient Concerns: The relapse of the cutaneous and the new onset of severe renal involvement of cryoglobulinemic vasculitis occurred three weeks after the second dose of the mRNA Moderna coronavirus disease 2019 vaccination and two days after the first dose of mRNA Pfizer coronavirus disease 2019 vaccination in the first and second patient, respectively. Read More

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Proteomic Profiling of Cryoglobulinemia.

Front Immunol 2022 23;13:855513. Epub 2022 May 23.

Department of Laboratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.

Objective: We aimed to explore and identify candidate protein biomarkers of cryoglobulinemia (CGE) in disease control patients with negative cryoglobulin (DC) or healthy controls (HCs).

Methods: The tandem mass tag (TMT)-labeled serum quantitative proteomics approach was used to identify differentially expressed proteins between the CGE and DC groups. Ingenuity pathway analysis was used for functional annotation of differentially expressed proteins. Read More

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Case of cryoglobulinaemia associated with chronic hepatitis B.

BMJ Case Rep 2022 May 27;15(5). Epub 2022 May 27.

Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

We present a case of a woman in her 50s with chronic hepatitis B (CHB) who had a longstanding history of arthralgia and swollen joints associated with severe fatigue. Investigations were consistent with a diagnosis of hepatitis B virus (HBV)-related cryoglobulinaemia. Two months after treatment with tenofovir alafenamide, an antiviral therapy for HBV, there was a significant improvement of her symptoms and undetectable serum cryoglobulins. Read More

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Cryoglobulinemia and double-filtration plasmapheresis: Personal experience and literature review.

Ther Apher Dial 2022 May 18. Epub 2022 May 18.

Department of Nephrology, Hemodialysis, Apheresis, and Kidney Transplantation, Grenoble University Hospital, Grenoble, France.

Background: Cryoglobulinemia is defined as the presence of an abnormal immunoglobulin that may be responsible for vasculitis of small-caliber vessels. Apheresis can be used in order to temporarily eliminate circulating cryoglobulins. The aim of this study was to assess the effectiveness of apheresis (double-filtration plasmapheresis-DFPP-) in symptomatic and/or severe cryoglobulinemias. Read More

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Renal manifestations of hepatitis E among immunocompetent and solid organ transplant recipients.

World J Hepatol 2022 Mar;14(3):516-524

Department of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States.

Hepatitis E virus (HEV) infections are generally self-limited. Rare cases of hepatitis E induced fulminant liver failure requiring liver transplantation are reported in the literature. Even though HEV infection is generally encountered among developing countries, a recent uptrend is reported in developed countries. Read More

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Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients.

PLoS One 2022 13;17(5):e0268180. Epub 2022 May 13.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: High dosage and longer duration of antiviral treatment has been suggested to treat cryoglobulinemia patients. We aimed to investigate the efficacy of antiviral treatment in cryoglobulinemia patients and analyze the associated factors of persistent cryoglobulinemia.

Methods: Totally 148 patients after completion of anti-HCV treatment were enrolled in our study. Read More

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Comparing cases of type I cryoglobulinemia with histopathologic findings of vasculitis.

JAAD Case Rep 2022 May 2;23:160-161. Epub 2022 Mar 2.

Department of Dermatology, University of Florida, Gainesville, Florida.

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Cutaneous manifestations of acute kidney injury.

Clin Kidney J 2022 May 9;15(5):855-864. Epub 2021 Dec 9.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Central Parkway, Newcastle upon Tyne, UK.

Acute kidney injury (AKI) is a common medical problem with a multitude of aetiologies. Prompt diagnosis and management is key in the prevention of complications. Cutaneous signs can often give diagnostic clues of underlying systemic diseases causing AKI. Read More

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Ocular Syphilis: A Case Report.

Cureus 2022 Mar 26;14(3):e23509. Epub 2022 Mar 26.

Internal Medicine, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, PRT.

Neurosyphilis refers to the involvement of the central nervous system by . Ocular syphilis can present with a range of manifestations, uveitis being the most common, and it can occur at any stage of acquired syphilis. There are multiple tests available for the diagnosis of syphilis. Read More

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Cutaneous thrombotic microangiopathy due to mixed cryoglobulinemia in a young woman.

J Dtsch Dermatol Ges 2022 06 29;20(6):878-880. Epub 2022 Apr 29.

Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

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A case of type I cryoglobulinemia vasculitis associated with monoclonal gammopathy of undetermined significance exacerbated by a progression to multiple myeloma.

QJM 2022 Apr 28. Epub 2022 Apr 28.

Haematology Unit, Medical Department, Penang General Hospital,Jalan Residensi, 10990 George Town, Pulau Pinang, Malaysia.

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B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.

Hematol Oncol 2022 Apr 23. Epub 2022 Apr 23.

MASVE Interdepartmental Hepatology Center, Department of Experimental and Clinical Medicine, University of Florence, Center for Research and Innovation CRIA-MASVE, Firenze, Italy.

Cryoglobulinemic Vasculitis (CV) is an autoimmune/lymphoproliferative disorder associated with HCV infection that in 5%-10% of cases evolves into a B cell Non-Hodgkin's Lymphoma (NHL). B-cell activating factor (BAFF) is a key regulator in B-cell development and survival. Particular genetic variants are responsible for BAFF signaling impairment in autoimmune and neoplastic diseases. Read More

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Corrigendum: Clinical Characteristics of Cryoglobulinemia With Cardiac Involvement in a Single Center.

Front Cardiovasc Med 2022 1;9:899282. Epub 2022 Apr 1.

Department of Family Medicine & Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing, China.

[This corrects the article DOI: 10.3389/fcvm.2021. Read More

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Emergence of proteinase 3-antineutrophil cytoplasmic antibody-associated glomerulonephritis with mesangial immune deposition during the clinical course of IgG λ monoclonal gammopathy of uncertain significance.

CEN Case Rep 2022 Apr 14. Epub 2022 Apr 14.

Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan.

Patients with monoclonal gammopathy of uncertain significance (MGUS) is sometimes associated with renal diseases, usually due to the deposition of secreted monoclonal immunoglobulin or a fragment thereof, a condition which is defined as monoclonal gammopathy of renal significance. Patients with MGUS appear to be at increased risk for various autoimmune conditions. We report the case of a 68-year-old man developed nephritic syndrome and mild renal insufficiency during the course of IgG λ MGUS. Read More

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Non HCV-Related Mixed Cryoglobulinemic Vasculitis With Biopsy-Proven Renal Involvement: The Effects of Rituximab.

Front Med (Lausanne) 2022 28;9:819320. Epub 2022 Mar 28.

Nephrology and Dialysis Unit (The European Rare Kidney Disease Reference Network, The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases, and the European Reference Network That Aims at Improving the Care of Patients With Rare Immunological Disorders), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hub Hospital, Turin, Italy.

In the countries where HCV infection is still endemic, about 90% of subjects with mixed cryoglobulinemia had previously been infected with HCV and about 80% are RNA positive. Remarkable results in severe HCV-related cryoglobulinemic vasculitis have been obtained with Rituximab. Details of the clinical characteristics and effective treatment of non HCV-related cryogloulinemic syndromes are presently lacking. Read More

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Painful ulcerations: the sole clinical sign of mixed cryoglobulinaemia secondary to marginal zone lymphoma.

BMJ Case Rep 2022 Apr 7;15(4). Epub 2022 Apr 7.

Dermatology, Box Hill Hospital, Box Hill, Victoria, Australia

A man in his 70s with background vascular disease presented with 7 months of painful non-resolving lower leg ulcers with eschar and petechiae, left lower ear lobe ulceration and dusky inflammation of the right ear. He demonstrated good bilateral pedal pulses and no peripheral oedema. No lymphadenopathy was palpated. Read More

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[VEXAS syndrome : when do we have to consider it ?]

Rev Med Suisse 2022 Apr;18(776):652-659

Service d'immunologie et d'allergologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.

VEXAS syndrome was recently discovered in patients who developed late in adulthood an inflammatory syndrome with fever, cytopenias, dysplastic bone marrow, cutaneous and pulmonary neutrophilic inflammation, arthritis, chondritis, or vasculitis. It is the result of an inactivating somatic mutation affecting methionine codon 41 of the UBA1 gene which encodes an ubiquitin activating enzyme (E1). Systemic corticosteroids generally reduce symptoms, while other immunosuppressive drugs only have limited long-term effects. Read More

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AKI in a Patient with Fever, Rash, and Joint Pain.

Kidney360 2021 05 27;2(5):918-919. Epub 2021 May 27.

Section of Nephrology, Yale School of Medicine, New Haven, Connecticut.

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Evolution of Cryoglobulinemia in Direct-Acting Antiviral-Treated Asian Hepatitis C Patients With Sustained Virological Responses: A 4-Year Prospective Cohort Study.

Front Immunol 2022 8;13:823160. Epub 2022 Mar 8.

Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: How cryoglobulinemia evolves after sustained virological response (SVR) following direct-acting antiviral (DAA) treatment in Asian hepatitis C virus (HCV)-infected patients remains elusive.

Methods: A prospective cohort study was conducted in 422 Taiwanese patients (358 completed DAA therapy and 353 experienced SVRs). Serum cryoglobulins were surveyed at baseline and every 3-6 months posttherapy. Read More

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Type I cryoglobulinaemia leading to bilateral above-the-knee amputations.

BMJ Case Rep 2022 03 29;15(3). Epub 2022 Mar 29.

School of Medicine, University of North Carolina System, Chapel Hill, North Carolina, USA.

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The wide spectrum of cryoglobulinemic vasculitis and an overview of therapeutic advancements.

Clin Exp Med 2022 Mar 28. Epub 2022 Mar 28.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro" Medical School, Polyclinic, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

Immunoglobulins that reversibly precipitate at temperatures below 37 °C are called cryoglobulins (CGs). Cryoglobulinemia often manifests as cryoglobulinemic vasculitis (CV), whose symptoms range in severity from purpuric eruptions to life-threatening features. The majority of CV patients are infected with hepatitis C virus (HCV), whereas lymphoproliferative disorders or connective tissue diseases (CTD) are commonly diagnosed among patients with CV of non-infectious origin. Read More

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Cryofibrinogenemia: What Rheumatologists Should Know.

Curr Rheumatol Rev 2022 Mar 25. Epub 2022 Mar 25.

Hospital Santa Izabel, Praça Almeida Couto 500, CEP: 40.000-000, Salvador, Bahia, Brazil.

Cryofibrinogenemia refers to the presence of cryofibrinogen in plasma. This protein has the property of precipitating at lower temperatures. Cryofibrinogenemia is a rare disorder, clinically characterized by skin lesions, such as ulcers, necrosis, livedo reticularis, arthralgia, thrombosis, and limb ischemia. Read More

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A "cat"-astrophic case of Bartonella infective endocarditis causing secondary cryoglobulinemia: a case report.

BMC Rheumatol 2022 Mar 25;6(1):16. Epub 2022 Mar 25.

The Kellgren Centre of Rheumatology, Manchester Royal Infirmary, Oxford Road, Manchester, UK.

Background: Culture-negative infective endocarditis (IE) constitutes approximately 10% of all cases of IE. Bartonella endocarditis is a common cause of culture-negative endocarditis and is associated with a high mortality rate. To date, no cases of Bartonella IE has been reported in association with cryoglobulinemia in the UK. Read More

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Case Report: Clinical and Pathological Findings of a Recurrent C3 Glomerulopathy With Superimposed Membranoproliferative Glomerulonephritis Pattern and Cryoglobulinemia Associated With COVID-19.

Front Pediatr 2022 4;10:827466. Epub 2022 Mar 4.

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.

Coronavirus disease 2019 (COVID-19) may cause a wide spectrum of kidney pathologies. The impact of COVID-19 is unclear in the context of the complement system abnormalities, including C3 glomerulopathy (C3G). In this report, we describe a young adult receiving a kidney transplant for C3 glomerulopathy (C3G), a disorder of the alternative complement pathway. Read More

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[Cryoglobulinemic vasculitis].

Z Rheumatol 2022 May 8;81(4):300-304. Epub 2022 Mar 8.

Klinik für Innere Medizin - Hepatologie, Gastroenterologie, Infektiologie & Diabetologie, AMEOS Klinikum St. Clemens Oberhausen, Oberhausen, Deutschland.

Cryoglobulinemic vasculitis (CV) is a rare immune complex disease of small vessels (capillaries, venules or arterioles) with detection of cryoglobulins (CG). These are serum proteins that precipitate at temperatures below the normal body temperature. The laboratory diagnostics are logistically challenging because the temperature of the blood sample must be maintained continuously at 37 °C until arrival in the laboratory to prevent early precipitation of the proteins with adsorption to corpuscular blood components. Read More

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