4,586 results match your criteria Cryoglobulinemia


[Cryoglobulinemia for use].

Rev Prat 2018 Dec;68(10):1107-1112

Service d'immunohématologie, hôpital Saint-Louis, AP-HP, Paris, France.

Cryoglobulinemia. Cryoglobulinemia is defined by the presence of a circulating cryoglobulin, a cold-precipitating immunoglobulin. The typing of this cryoglobulin is fundamental. Read More

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December 2018
2 Reads

[Rapid progressive glomerulonephritis].

Authors:
Marion Haubitz

Internist (Berl) 2019 Mar 13. Epub 2019 Mar 13.

Medizinische Klinik III - Nieren- und Hochdruckerkrankungen, Klinikum Fulda gAG, Universitätsmedizin Marburg - Campus Fulda, Pacelliallee 4, 36043, Fulda, Deutschland.

The rapid progressive glomerulonephritis is an emergency case. Renal function is rapidly lost within weeks or a few months (rarely within days) due to necrotizing extracapillary proliferative crescentic glomerulonephritis. Early diagnosis and treatment improve prognosis, as the best prognostic marker is creatinine when treatment is initiated. Read More

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http://link.springer.com/10.1007/s00108-019-0575-x
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http://dx.doi.org/10.1007/s00108-019-0575-xDOI Listing
March 2019
4 Reads

IgG1 and IgG4 antibodies against Core and NS3 antigens of hepatitis C virus.

Rev Soc Bras Med Trop 2019 Mar 7;52:e20180491. Epub 2019 Mar 7.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, BA, Brasil.

Introduction: IgG subclasses involved in the immune response to hepatitis C virus (HCV) antigens have been rarely studied. We investigated the immune response mediated by IgG1 and IgG4 antibodies against the recombinant core and NS3 antigens in patients with chronic hepatitis C.

Methods: Sixty patients infected with HCV genotype 1 without antiviral treatment and 60 healthy subjects participated in the study. Read More

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http://dx.doi.org/10.1590/0037-8682-0491-2018DOI Listing
March 2019
2 Reads

Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report.

World J Hepatol 2019 Feb;11(2):226-233

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.

Background: Necrolytic acral erythema (NAE) is a rare dermatological disorder, which is associated with hepatitis C virus (HCV) infection or zinc deficiency. It is characterized by erythematous or violaceous lesions occurring primarily in the lower extremities. The treatment includes systemic steroids and oral zinc supplementation. Read More

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https://www.wjgnet.com/1948-5182/full/v11/i2/226.htm
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http://dx.doi.org/10.4254/wjh.v11.i2.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393713PMC
February 2019
4 Reads

Disseminated skin necroses in a patient with multiple myeloma and monoclonal cryoglobulinaemia.

J Eur Acad Dermatol Venereol 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, 44791, Bochum, Germany.

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http://dx.doi.org/10.1111/jdv.15403DOI Listing
February 2019

Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant: Case report and literature review.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):239-249

Division of Nephrology, Maggiore Hospital and IRCCS Foundation; School of Medicine, University of Milano, Milano, Italy.

Chronic hepatitis C virus (HCV) infection is associated with numerous extra-hepatic complications, including neurological and renal manifestations. We describe the case of a 67-year-old Caucasian man with HCV-associated cryoglobulinemic glomerulonephritis, cirrhosis, and hepatocellular carcinoma. The early posttransplant course was complicated by fibrosing cholestatic hepatitis due to recurrent HCV in the graft (HCV RNA up to 44,944,438 IU/mL). Read More

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February 2019
2 Reads

HCV-Associated Nephropathies in the Era of Direct Acting Antiviral Agents.

Front Med (Lausanne) 2019 8;6:20. Epub 2019 Feb 8.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Hepatitis C virus (HCV) infection is a systemic disorder that frequently associates with extrahepatic manifestations, including nephropathies. Cryoglobulinemia is a typical extrahepatic manifestation of HCV infection that often involves kidneys with a histological pattern of membranoproliferative glomerulonephritis. Other, less common renal diseases related to HCV infection include membranous nephropathy, focal segmental glomerulosclerosis, IgA nephropathy, fibrillary and immunotactoid glomerulopathy. Read More

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http://dx.doi.org/10.3389/fmed.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376251PMC
February 2019
1 Read

Extensive cutaneous necrosis in monoclonal cryoglobulinemia: an example of monoclonal gammopathy of cutaneous significance.

Authors:
D Lipsker

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Faculté de Médecine, Université de Strasbourg et Clinique Dermatologique, Hôpitaux Universitaires, Strasbourg, France.

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http://dx.doi.org/10.1111/jdv.15397DOI Listing
February 2019
1 Read

[Essential mixed cryoglobulinemia type II: case report.]

Rev Fac Cien Med Univ Nac Cordoba 2018 11 13;75(4):292-298. Epub 2018 Nov 13.

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The cryoglobulinemic syndrome is produced by precipitating immunoglobulins at low temperatures. Its production is associated with several causes, such as lymphoproliferative disorders, chronic infections and autoimmune disorders. However, the etiology is unknow. Read More

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http://dx.doi.org/10.31053/1853.0605.v74.n3.17550DOI Listing
November 2018
2 Reads

Cryoglobulinemia: An update in 2019.

Joint Bone Spine 2019 Feb 4. Epub 2019 Feb 4.

Sorbonne universités, UPMC Université Paris 06, Inserm, UMR S 959, immunology immunopathology immunotherapy (I3), 75005, Paris, France; Biotherapy (CIC-BTi) and inflammation-immunopathology-biotherapy department (DHU i2B), hôpital Pitié-Salpêtrière, AP-HP, 75651, Paris, France; AP-HP, groupe hospitalier Pitié-Salpêtrière, department of internal medicine and clinical immunology, centre national de référence maladies autoinflammatoires et amylose inflammatoire, centre national de références maladies autoimmunes systémiques rares, 75013, Paris, France. Electronic address:

Cryoglobulinemia is defined as the persistent presence in serum of abnormal immunoglobulins (Igs) that precipitate at low temperatures and dissolve again upon warming. Cryoglobulins may be composed only of a monoclonal Ig (simple type I cryoglobulinemia), of a monoclonal Ig bound to the constant domain of polyclonal Ig heavy chains (mixed type II cryoglobulinemia), or only of polyclonal Igs (mixed type III cryoglobulinemia). The manifestations of type I cryoglobulinemia are often related to intravascular obstruction, whereas those seen in the mixed cryoglobulinemias often originate in true immune complex-mediated vasculitis. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.016DOI Listing
February 2019
10 Reads

[Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions].

Nephrol Ther 2019 Jan 31. Epub 2019 Jan 31.

Service de néphrologie-dialyse, centre hospitalier de Cahors, 335, rue du président-Wilson, 46000 Cahors, France; Département de néphrologie et transplantation d'organes, CHU Rangueil, 1, avenue du Professeur-Jean-Poulhès, 31400 Toulouse, France; Inserm U563, IFR-BMT, CHU Purpan, 105, avenue de Cassalardit, 31300 Toulouse, France; Université Paul Sabatier, route de Narbonne, 31330 Toulouse, France.

Known in less than half a century, borreliosis, or Lyme disease, is a zoonosis caused by the tick bite. It is the most common vector disease in Europe and the United States. Borrelia burgdorferi sensu lato, the bacterium in question, is fitted with a "cunning device" that allows it to trick the immune system and implant the infection chronically. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183065
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http://dx.doi.org/10.1016/j.nephro.2018.09.004DOI Listing
January 2019
8 Reads

Neurologic manifestations associated with cryoglobulinemia: A single center experience.

J Neurol Sci 2019 Mar 25;398:121-127. Epub 2019 Jan 25.

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. Electronic address:

Introduction: Limited information is available describing the spectrum of neurological complications of cryoglobulinemia.

Methods: Single center retrospective review of patients with neurologic symptoms and elevated serum cryoglobulins, with their potential association being classified as definite, possible, or unlikely using defined criteria.

Results: Among 492 patients, 131 (87 classified as definite and 44 as possible) had neurologic symptoms associated with cryoglobulinemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193005
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http://dx.doi.org/10.1016/j.jns.2019.01.041DOI Listing
March 2019
7 Reads

HCV-associated mixed cryoglobulinemia and b-cell non-Hodgkin's lymphoma - pathogenetically related problems.

Ter Arkh 2018 Jun;90(6):112-120

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University), Moscow, Russia.

Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. Read More

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http://dx.doi.org/10.26442/terarkh2018906112-120DOI Listing
June 2018
1 Read

The modern therapy of systemic vasculitides: perspectives and challenges.

Ter Arkh 2018 Feb;90(1):76-85

Sechenov First Moscow State Medical University, Moscow, Russia.

Systemic vasculitis is a heterogeneous group of inflammatory diseases, which are classified according to the diameter of the affected vessels. The treatment of systemic vasculitis is no longer empirical, because of increasing number of randomized clinical trials in this field. In recent years, there was a trend to limit the cumulative dose of glucocorticosteroids and immunosuppressive drugs, partially through biological drugs usage. Read More

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http://dx.doi.org/10.26442/terarkh201890176-85DOI Listing
February 2018
1 Read

Long-lasting persistence of large B-cell clones in hepatitis C virus-cured patients with complete response of mixed cryoglobulinaemia vasculitis.

Liver Int 2019 Jan 28. Epub 2019 Jan 28.

Division of Clinical Immunology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Background & Aims: Hepatitis C virus (HCV)-related mixed cryoglobulinaemia vasculitis (MCV) is characterized by the expansion of rheumatoid factor-producing B-cell clones. The aim of this study was to assess whether B-cell clones may persist in these patients after the clearance of the virus with antiviral therapy, and whether their persistence influences clinical outcomes.

Methods: Forty-five HCV-cured MCV patients were followed up for a median of 18. Read More

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http://dx.doi.org/10.1111/liv.14053DOI Listing
January 2019
2 Reads

Concomitant cryoglobulinemic vasculitis and cold agglutinin disease successfully treated with bortezomib: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14201

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Concomitant cryoglobulinemic vasculitis and cold agglutinin disease (CAD) is an extremely uncommon clinical scenario. The role of bortezomib in the treatment of cryoglobulinemic vasculitis needs further investigation.

Patient Concerns: A 72-year-old Chinese woman presented with a 25-year history of cyanosis of the extremities after cold exposure, which worsened and was accompanied with purpuric skin lesions and proteinuria in recent years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0004
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http://dx.doi.org/10.1097/MD.0000000000014201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358358PMC
January 2019
7 Reads

Cryoglobulinemia as a Possible Primer for TRALI: Report of a Case.

Lab Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.

Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Read More

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http://dx.doi.org/10.1093/labmed/lmy073DOI Listing
January 2019
1 Read

Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy.

Indian J Nephrol 2018 Nov-Dec;28(6):462-464

Department of Nephrology, Institute of Liver and Biliary Sciences, New Delhi, India.

Hepatitis C virus (HCV) infection has been shown to affect kidneys with various histopathological pattern on the kidney biopsy. These commonly include a membranoproliferative glomerulonephritis (MPGN) pattern with mixed cryoglobulinemia (CG), thrombotic microangiopathy, membranous nephropathy, and vasculitis affecting medium and small vessels of the kidneys causing polyarteritis nodosa. It has been rarely associated with MPGN without detectable CG. Read More

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http://dx.doi.org/10.4103/ijn.IJN_235_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309397PMC
January 2019
1 Read

The complexity of an overlap type resistant cryoglobulinemia: a case report and review of the literature.

Clin Rheumatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine C, Wolfson Medical Center, 61 Halochamim Street, 58100, Holon, Israel.

Type I cryoglobulinemia is associated with B cell proliferative diseases, whereas essential mixed cryoglobulinemia is classically associated with infections, malignancy, and autoimmune diseases, but may be idiopathic. Prognosis in patients with grave manifestations and renal involvement is often poor. We report a case of a 40-year-old woman, 2 weeks post-partum for pre-eclampsia who was hospitalized with nephritic syndrome and acute renal failure. Read More

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http://dx.doi.org/10.1007/s10067-018-04423-yDOI Listing
January 2019
3 Reads

Improvement in Waldenström's Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals.

Ann Hepatol 2018 Oct;17(6):1072-1077

Gastroenterology Unit, Ospedale Policlinico San Martino, IRCCS per l'Oncologia, University of Genoa, Genoa, Italy.

Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin's Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antiviral treatment may be effective in inducing HCV-associated lymphoma regression. The recent advent of direct acting antivirals (DAAs) in the therapeutic armamentarium of HCV infection made possible treatment of patients with advanced liver disease. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7208DOI Listing
October 2018
4 Reads

Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4.

Iran J Kidney Dis 2018 Nov;12(6):382-384

Urology and Nephrology Center, Mansoura University, Egypt.

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Read More

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November 2018
4 Reads

Comment on: type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration.

Authors:
Mathew Sheridan

Br J Haematol 2018 Nov 22. Epub 2018 Nov 22.

Bristol Haematology and Oncology Centre, Bristol, UK.

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http://dx.doi.org/10.1111/bjh.15635DOI Listing
November 2018
3 Reads

Serological profile of asymptomatic HCV positive patients with low level of cryoglobulins.

Biofactors 2018 Dec 18. Epub 2018 Dec 18.

Dipartimento di Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

Clinical spectrum of hepatitis C virus (HCV)-related cryoglobulinemia varies from an asymptomatic presentation to severe vasculitis and lymphoma. A recent study in HCV-negative patients suggests that low cryoglobulins (CGs) levels are responsible for severe renal and neurological complications. The aim of this study was to identify a panel of serological biomarkers associated with low levels of CGs in HCV-positive patients. Read More

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http://doi.wiley.com/10.1002/biof.1485
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http://dx.doi.org/10.1002/biof.1485DOI Listing
December 2018
9 Reads

[Hemodialysis treatment as a trigger cause of cryoglobulinemic purpura: a case report].

G Ital Nefrol 2018 Dec;35(6)

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, ROMA.

We describe the clinical case of a patient who developed mixed cryoglobulinemia syndrome after hemodialysis treatment with dialysate temperature lower than 36°C despite the negativization of the viral genome for HCV after eradication therapy. Read More

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December 2018
3 Reads

The association of hepatitis C infection with the onset of CKD and progression into ESRD.

Semin Dial 2019 03 29;32(2):108-118. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated atherosclerosis, insulin resistance, and chronic inflammation. Read More

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http://doi.wiley.com/10.1111/sdi.12759
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http://dx.doi.org/10.1111/sdi.12759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410728PMC
March 2019
29 Reads

Expert opinion on managing chronic HCV in patients with mixed cryoglobulinaemia vasculitis.

Antivir Ther 2018 ;23(Suppl 2):1-9

Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France.

Mixed cryoglobulinaemia vasculitis (CryoVas) is a small-vessel systemic vasculitis caused by deposition of mixed cryoglobulins and is characterized by a wide range of clinical symptoms. HCV is the primary cause of CryoVas, which is associated with significant morbidity and mortality. The mortality rate among patients with HCV-associated CryoVas is 3× that of the general population, with a 63% 10-year survival rate. Read More

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https://www.intmedpress.com/journals/avt/abstract.cfm?id=324
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http://dx.doi.org/10.3851/IMP3246DOI Listing
January 2018
12 Reads

Clinical practice: hepatitis C virus infection, cryoglobulinemia and cryoglobulinemic vasculitis.

Clin Exp Med 2019 Feb 14;19(1):1-21. Epub 2018 Nov 14.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari "Aldo Moro", Polyclinic, Piazza G. Cesare, 11, 70124, Bari, Italy.

Cryoglobulins are circulating immunoglobulins that reversibly precipitate at temperatures below 37 °C. Type-II cryoglobulins consist of monoclonal IgM/polyclonal IgG immune complexes (ICs), whereas in type-III cryoglobulins both IgM and IgG are polyclonal. The clinical condition resulting from the presence of cryoglobulins in the blood is called mixed cryoglobulinemia (MC), which can be asymptomatic or manifest as cryoglobulinemic vasculitis (CV). Read More

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http://link.springer.com/10.1007/s10238-018-0536-z
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http://dx.doi.org/10.1007/s10238-018-0536-zDOI Listing
February 2019
15 Reads

Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?

World J Gastroenterol 2018 Nov;24(41):4617-4621

Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, University of Campania "L. Vanvitelli", Naples 80138, Italy.

Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, among these there is an increased risk of atherosclerosis and cardiovascular disease as well as an increased cardiovascular mortality. Several direct and indirect HCV pro-atherogenic mechanisms have been proposed. HCV lives and replicates within carotid plaques, promoting a local environment of pro-atherogenic factors. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i41/4617.htm
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http://dx.doi.org/10.3748/wjg.v24.i41.4617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224469PMC
November 2018
17 Reads

Interleukin-17A and B-cell activating factor in chronic hepatitis C patients with or without asymptomatic mixed cryoglobulinemia: effects of antiviral treatment and correlations with vitamin D.

Ann Gastroenterol 2018 Nov-Dec;31(6):705-711. Epub 2018 Sep 14.

2nd Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.

Background: Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating factor (BAFF) in MC has been described, but the role of interleukin (IL)-17A is less clear.

Methods: Serum concentrations of IL-17A, BAFF and 25-OH vitamin D were measured in CHC patients at baseline, end of treatment, and 6 months post-treatment with pegylated interferon-α and ribavirin, versus 12 healthy controls. Read More

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http://www.annalsgastro.gr/index.php/annalsgastro/article/do
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http://www.annalsgastro.gr/files/journals/1/earlyview/2018/e
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http://dx.doi.org/10.20524/aog.2018.0310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191865PMC
September 2018
6 Reads

Hepatitis C virus infection could affect the pathogenesis of ischemic heart diseases in northern Japan.

Hepatol Res 2019 Mar 6;49(3):355-359. Epub 2018 Dec 6.

Department of Hepatology, Sendai Kousei Hospital, Sendai, Japan.

Aims: Previously, our group reported that lymphotropic hepatitis C virus (HCV) could induce various kinds of immune dysfunctions. The immune dysfunctions could cause vascular disease by inducing cryoglobulinemia. It has been reported that ischemic heart diseases might be caused by HCV. Read More

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http://dx.doi.org/10.1111/hepr.13283DOI Listing
March 2019
4 Reads

Comment on: Type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration.

Authors:
Utku Iltar

Br J Haematol 2018 Oct 29. Epub 2018 Oct 29.

Department of Haematology, Antalya Training and Research Hospital, Antalya, Turkey.

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http://dx.doi.org/10.1111/bjh.15636DOI Listing
October 2018
2 Reads

Incidence and Characteristics of de novo Renal Cryoglobulinemia After Direct-Acting Antivirals Treatment in an Egyptian Hepatitis C Cohort.

Nephron 2018 25;140(4):275-281. Epub 2018 Oct 25.

Department of Internal Medicine, Nephrology Unit, School of Medicine, Cairo University, Cairo, Egypt.

Introduction: The side effects profile of the new direct--acting antivirals for the treatment of hepatitis C virus (HCV) is not fully elucidated.

Objective: In this cross-sectional study, we aim to describe the incidence and characteristics of a novel observation of de novo renal cryoglobulinemic glomerulonephritis after successful treatment with DAA.

Methodology: A total of 12,985 Hepatitis C Patients (genotype IV) received the new DAA. Read More

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http://dx.doi.org/10.1159/000493807DOI Listing
October 2018
2 Reads

Uncommon immune-mediated extrahepatic manifestations of HCV infection.

Expert Rev Clin Immunol 2018 12 26;14(12):1089-1099. Epub 2018 Oct 26.

a Division of Internal Medicine, Department of Medical and Surgical Sciences , "Luigi Vanvitelli" University of Campania , Naples , Italy.

Introduction: Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1538790DOI Listing
December 2018
3 Reads

[Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene].

Arkh Patol 2018;80(5):40-45

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper describes a case of essential cryoglobulinemia unassociated with hepatitis B and C viruses. The morphological substrate of the disease was exclusively proliferative endothrombovasculitis without destructive changes in the walls of affected vessels. In addition, in the late stage of the disease, there was its unusual manifestation associated with inflammation of the mesentery arteriolar walls and with the formation of occlusive blood clots in their lumens, which led to severe abdominal diseases. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/5/dow
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http://dx.doi.org/10.17116/patol20188005140DOI Listing
January 2018
10 Reads

Persistence of Pathogenic B-Cell Clones and Relapse of Cryoglobulinemic Vasculitis in HCV-Cured Patients.

Gastroenterology 2019 01 10;156(1):291. Epub 2018 Oct 10.

Department of Clinical Medicine, Laboratory Affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183515
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http://dx.doi.org/10.1053/j.gastro.2018.06.094DOI Listing
January 2019
2 Reads

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis-A Case Report with Literature Review.

Case Rep Med 2018 13;2018:3625139. Epub 2018 Sep 13.

Internal Medicine Department, Beaumont Hospital, Royal Oak, MI, USA.

Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain-Barre syndrome, and pleural or pericardial effusion. Read More

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http://dx.doi.org/10.1155/2018/3625139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158949PMC
September 2018
8 Reads

IgG cryoglobulinemia.

Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6057-6062

Clinical Pathology Laboratory, Ospedale Madre Giuseppina Vannini, Rome, Italy.

Objective: Mixed Cryoglobulinemia is the most well-known Hepatitis C Virus (HCV)-associated extrahepatic manifestation. MC is both an autoimmune and B-lymphoproliferative disorder. Cryoglobulins (CGs) are classified into three groups according to immunoglobulin (Ig) composition: type I is composed of one isotype or Ig class. Read More

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http://dx.doi.org/10.26355/eurrev_201809_15943DOI Listing
September 2018
17 Reads

A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12355

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School.

Rationale: Type I cryoglobulinemia is a rare and life-threatening condition. It occurs mainly in B-cell lymphoproliferative disorder. In almost half of the patients, type I cryoglobulinemia is characterized by severe cutaneous involvement. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0003
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http://dx.doi.org/10.1097/MD.0000000000012355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181604PMC
September 2018
5 Reads

Autoimmune Kidney Diseases Associated with Chronic Viral Infections.

Rheum Dis Clin North Am 2018 11 7;44(4):675-698. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, GRB 7, Boston, MA 02114, USA. Electronic address:

Autoimmune kidney diseases triggered by viruses are an important cause of kidney disease in patients affected by chronic viral infection. Hepatitis B virus (HBV) infection is associated with membranous nephropathy and polyarteritis nodosa. Hepatitis C virus (HCV) infection is a major cause of cryoglobulinemic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.006DOI Listing
November 2018
3 Reads

Renal complications of liver diseases.

Expert Rev Gastroenterol Hepatol 2018 Nov 11;12(11):1135-1142. Epub 2018 Oct 11.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation rénale , Grenoble-Alpes , France.

Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the major causes of chronic liver disease. HBV and HCV affect nearly 7% of the world's population. Extra-hepatic complications and particularly renal failure have different mechanisms and manifestations. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530984DOI Listing
November 2018
16 Reads

Editorial: interferon-free DAAs are a great boon for patients with hepatitis C and cryoglobulinaemia.

Aliment Pharmacol Ther 2018 Oct;48(7):770-771

The core Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/apt.14899DOI Listing
October 2018
3 Reads

Editorial: interferon-free DAAs are a great boon for patients with hepatitis C and cryoglobulinaemia-Authors' reply.

Aliment Pharmacol Ther 2018 Oct;48(7):772-773

Department of Experimental and Clinical Medicine and Department of Oncology, Interdepartmental Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy.

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http://dx.doi.org/10.1111/apt.14936DOI Listing
October 2018
3 Reads

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management.

Kidney Int 2018 10;94(4):663-673

Division of Hepatology, University of Miami, Miami, Florida, USA. Electronic address:

Infection with the hepatitis C virus (HCV) has adverse liver, kidney, and cardiovascular consequences in patients with chronic kidney disease (CKD), including those on dialysis therapy and in those with a kidney transplant. Since the publication of the original Kidney Disease: Improving Global Outcomes (KDIGO) HCV Guideline in 2008, major advances in HCV management, particularly with the advent of direct-acting antiviral therapies, have now made the cure of HCV possible in CKD patients. In addition, diagnostic techniques have evolved to enable the noninvasive diagnosis of liver fibrosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183044
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http://dx.doi.org/10.1016/j.kint.2018.06.011DOI Listing
October 2018
10 Reads

Apheresis treatment of cryoglobulinemic vasculitis: A multicentre cohort study of 159 patients.

Transfus Apher Sci 2018 Oct 26;57(5):639-645. Epub 2018 Jun 26.

Infectious Disease Unit, Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Italy. Electronic address:

Objective: To assess the effectiveness of apheresis therapy (AT) in treating the clinical manifestations of patients with complicated cryoglobulinemic vasculitis (CV).

Methods: A retrospective cohort study of 159 CV patients attending 22 Italian Centers who underwent at least one AT session between 2005 and 2015. The response to AT was evaluated on the basis of a defined grading system. Read More

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http://dx.doi.org/10.1016/j.transci.2018.06.005DOI Listing
October 2018
7 Reads

Correlation of CCR5 and NLRP3 gene polymorphisms with renal damage due to hepatitis C virus-related cryoglobulinemia.

Exp Ther Med 2018 Oct 1;16(4):3055-3059. Epub 2018 Aug 1.

Department of Infectious Disease, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Correlation of C-C chemokine receptor type 5 (CCR5) and NACHT, LRR and PYD domain-containing protein 3 (NLRP3) gene polymorphisms with renal damage due to hepatitis C virus (HCV)-related cryoglobulinemia were investigated. The 1:1 matched case-control study design was adopted, 171 patients with renal damage due to HCV-related cryoglobulinemia were selected as the case group, and 171 patients without renal damage were selected as the control group. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect the polymorphisms of locus rs1799987A/G in CCR5 gene and locus rs35829419A/C in NLRP3 gene of 171 pairs of HCV patients. Read More

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http://dx.doi.org/10.3892/etm.2018.6558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125838PMC
October 2018
4 Reads

Mixed cryoglobulinemic membranoproliferative glomerulonephritis due to monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12416

Division of Nephrology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital.

Rationale: Membranoproliferative glomerulonephritis (MPGN) can be induced by autoimmune diseases, chronic infection, chronic hepatitis, and paraproteins (including cryoglobulinemia). In addition, the mixed cryoglobulinemic MPGN is reported to be highly correlated with hepatitis C virus (HCV) infection.

Patient Concerns: We reported a rare case of a 61-year-old woman without a history of viral hepatitis infection; she presented with bilateral leg edema and proteinuria. Read More

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http://dx.doi.org/10.1097/MD.0000000000012416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156052PMC
September 2018
4 Reads

Staphylococcal Infection-Related Glomerulonephritis With Cryoglobulinemic Features.

Kidney Int Rep 2018 Sep 2;3(5):1128-1134. Epub 2018 Jun 2.

Department of Pathology, Sharp Memorial Hospital, San Diego, California, USA.

Introduction: Staphylococcal infection-related glomerulonephritis (GN) has been shown to represent a unique form of infection-related GN that contains IgA-dominant deposits and is often seen concurrently with the bacterial infection. Biopsies commonly reveal an endocapillary proliferative and/or exudative or mesangial proliferative GN. Rare cases have been reported to show cryoglobulin-like features, including hyaline pseudothrombi and wireloop deposits; however, detailed characterization of these cases is lacking. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127436PMC
September 2018
6 Reads

Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia.

Hematol Oncol 2018 Sep 7. Epub 2018 Sep 7.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Read More

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http://dx.doi.org/10.1002/hon.2539DOI Listing
September 2018
9 Reads

Initial Evaluation of the Patient with Waldenström Macroglobulinemia.

Hematol Oncol Clin North Am 2018 10 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.05.008DOI Listing
October 2018
6 Reads

Rituximab treatment for immune-complex-mediated membranoproliferative glomerulonephritis.

Immunotherapy 2018 Sep;10(12):1027-1031

Department of Nephrology, Peking University People's Hospital, Beijing,100044, China.

Immune-complex-mediated membranoproliferative glomerulonephritis (MPGN) is a new concept that refers to MPGN with immunoglobulin and C3 deposition in the kidney based on immunofluorescence examination. It is associated with pathological autoantibodies production. Rituximab, as an immunosuppressive agent, can eliminate B cells selectively. Read More

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http://dx.doi.org/10.2217/imt-2018-0031DOI Listing
September 2018
16 Reads