4,732 results match your criteria Cryoglobulinemia


Interactive Impacts from Hepatitis C Virus Infection and Mixed Cryoglobulinemia on Complement Levels.

Dig Dis Sci 2020 Jul 31. Epub 2020 Jul 31.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan.

Background/aim: How hepatitis C virus (HCV) infection and mixed cryoglobulinemia interactively affect complement levels remains elusive, and we aimed to elucidate it.

Methods: A prospective cohort study of 678 consecutive chronic HCV-infected (CHC) patients was conducted. Of 678, 438 had completed a course of anti-HCV therapy and 362 had achieved a sustained virological response (SVR). Read More

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http://dx.doi.org/10.1007/s10620-020-06507-9DOI Listing

Hydrophobicity and the Physico-Chemical Basis of Immunotolerance.

Authors:
Darja Kanduc

Pathobiology 2020 Jul 29:1-9. Epub 2020 Jul 29.

Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy,

This study analyzes the primary electrostatic interaction between the membrane-bound B-cell receptor and antigen peptide determinants, and identifies peptide frequency and hydrophobicity as the main factors that govern and shape immunotolerance versus immunoreactivity. Read More

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http://dx.doi.org/10.1159/000508903DOI Listing

Hypothermic circulatory arrest for aortic dissection with cryoglobulinemia.

J Card Surg 2020 Jul 28. Epub 2020 Jul 28.

Department of Rheumatology and Clinical Immunology, Graduate of School of Medicine, Kyoto University, Kyoto, Japan.

Cryoglobulinemia is a cold-reactive autoimmune disease. A 64-year-old man with active cryoglobulinemia presented Stanford type A acute aortic dissection. He had been treated with immunosuppressive drugs and plasma exchange (PE) at our hospital; subsequently, qualitative analysis of cryoglobulin (CG) was negative. Read More

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http://dx.doi.org/10.1111/jocs.14908DOI Listing

A Patient with Cryoglobulinemic Membranoproliferative GN (MPGN) Who Survived COVID-19 Disease: Case Presentation and Current Data of COVID-19 Infection in Dialysis and Transplanted Patients in Greece.

Medicina (Kaunas) 2020 Jul 17;56(7). Epub 2020 Jul 17.

Clinic of Nephrology and Renal Transplantation, Medical School, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.

The evolving pandemic of Coronavirus Disease 2019 has posed a substantial health risk worldwide. However, there is a paucity of data regarding the clinical course and the therapeutic management of patients with chronic kidney disease and COVID-19 infection. To date, most evidence has come from renal transplantation, with about 45 patients reported thus far, and the current data from the ERA-EDTA (ERACODA) registry for transplanted patients and patients on Renal Replacement Therapy (RRT); as for those with glomerular diseases, data are lacking. Read More

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http://dx.doi.org/10.3390/medicina56070355DOI Listing

Noninfectious mixed cryoglobulinaemic glomerulonephritis and monoclonal gammopathy of undetermined significance: a coincidental association?

BMC Nephrol 2020 Jul 23;21(1):293. Epub 2020 Jul 23.

Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.

Background: Cryoglobulins are cold-precipitable immunoglobulins that may cause systemic vasculitis including cryoglobulinaemic glomerulonephritis (CGN). Type 1 cryoglobulins consist of isolated monoclonal immunoglobulin (mIg), whereas mixed cryoglobulins are typically immune complexes comprising either monoclonal (type 2) or polyclonal (type 3) Ig with rheumatoid activity against polyclonal IgG. Only CGN related to type 1 cryoglobulins has been clearly associated with monoclonal gammopathy of undetermined significance (MGUS) using the conventional serum-, urine- or tissue-based methods of paraprotein detection. Read More

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http://dx.doi.org/10.1186/s12882-020-01941-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376917PMC

Acute massive pulmonary embolism during patient repositioning following excision of a thymic carcinoma in a patient affected by cryoglobulinemia.

J Card Surg 2020 Aug 11;35(8):2050-2052. Epub 2020 Jul 11.

Division of Cardiac Surgery, IRCCS Foundation Hospital San Matteo, Pavia, Italy.

Acute pulmonary embolism (APE) is a well-described complication following surgical procedures. The incidence of such a complication can be related to the presence of a peculiar patient's condition. Cryoglobulinemia, which consists in the presence of one or more immunoglobulins in the serum that precipitate at temperatures below 37°C and redissolve on warming, seems to increase the risk of thrombotic events. Read More

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http://dx.doi.org/10.1111/jocs.14759DOI Listing

Appropriateness of cryoglobulin test request from a sample of 4,963 patients obtained over 5 years. Comment on the article by Kolopp-Sarda et al.

Arthritis Rheumatol 2020 Jul 10. Epub 2020 Jul 10.

Chair and Complex Unit of Rheumatology, University of Modena and Reggio Emilia, Emilia, Italy.

Cryoglobulinemia is a rare pathology which is difficult to diagnose both clinically and in the laboratory. Symptoms vary and there are many difficulties in the detection of cryoglobulins (CRG), beginning with the necessity of maintaining the sample at 37°C during the pre-analytic phase until centrifugation in laboratory. To improve analytical accuracy, some authors have suggested the repetition of sample examinations, especially with persistent clinical suspicion, to avoid false-negative results. Read More

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http://dx.doi.org/10.1002/art.41434DOI Listing

Monoclonal gammopathy with significance: case series and literature review.

Neth J Med 2020 Jul;78(4):191-195

Department of Nephrology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.

Monoclonal gammopathy of undetermined significance (MGUS) is considered an asymptomatic precursor of malignant lymphoid disorders. This case series and literature review shows that these monoclonal gammopathies can cause significant morbidity. We describe a patient with angioedema due to acquired C1-esterase inhibitor deficiency, a patient with cryoglobulinemia type II causing skin vasculitis and glomerulonephritis, and a patient with glomerulonephritis and nephrotic syndrome - all caused by a monoclonal gammopathy that can be classified as MGUS. Read More

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Pearls and pitfalls: Cold-induced urticaria.

Allergy Asthma Proc 2020 07;41(4):301-304

Division of Allergy and Immunology, Naval Medical Center Portsmouth, Portsmouth, Virginia.

Cold-induced urticaria can take place either due to direct cold exposure, cryoglobulinemia, or genetic component (such as cryopyrin-associated periodic syndrome), which leads to the rapid onset of urticaria and/or angioedema. It is more common in younger patients and more likely to affect females compared with males. To increase awareness of such systemic reactions of anaphylaxis and provide a focused review of the differential diagnosis, underlying mechanisms, broad workup, and management of this disease process for allergy/immunology fellows, residents, general physicians, and general practitioners. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200033DOI Listing

Peripheral neuropathy in mixed cryoglobulinaemia: clinical assessment and therapeutic approach.

Clin Exp Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

Clinica delle Malattie Infettive, L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Italy.

Peripheral neuropathy (PN) has been detected in up to 69% of patients with mixed cryoglobulinaemic syndrome (MCS). PN should be considered in any patient with sensory and/or motor signs and symptoms in the limbs. Electrodiagnostic tests are mandatory for the diagnosis of PN. Read More

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Hepatitis C virus- related cryoglobulinemic vasculitis: A review of the role of the new direct antiviral agents (DAAs) therapy.

Autoimmun Rev 2020 Aug 12;19(8):102589. Epub 2020 Jun 12.

Clinical and Surgical Sciences, University of Trieste, Trieste, Italy.

Hepatitis C virus (HCV) infection affects about 70 million people worldwide. HCV is responsible for both hepatitis and extra-hepatic manifestations. Chronic infection has been shown to develop in about 70% of cases and can progress to cirrhosis or hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102589DOI Listing

Confirmed Cryoglobulinemia and Hyperviscosity Syndrome Secondary to Multiple Myeloma-IgA Kappa from Routine Blood Test: a Case Report.

Clin Lab 2020 Jun;66(6)

Background: Cryoglobulins and hyperviscosity syndrome (HS) sometimes occur in multiple myeloma (MM), which are considered clinical emergencies. In laboratory practice, aspiration failure in routine blood tests sometimes occurs when the sample is inadequate. Here, a case of cryoglobulinemia and HS associated with advanced multiple myeloma was reported, which unusually is initially confirmed by aspiration failure in a routine blood test with sufficient sample. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.191127DOI Listing
June 2020
1.084 Impact Factor

Clinical characteristics and treatment outcome of type I cryoglobulinemia in Chinese patients: a single-center study of 45 patients.

Ann Hematol 2020 Aug 13;99(8):1735-1740. Epub 2020 Jun 13.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, ,100730, Beijing, People's Republic of China.

To explore the clinical characteristics and outcomes in Chinese patients with type I cryoglobulinemia (CG), we retrospectively analyzed the clinical data, management, and outcomes of 45 patients diagnosed with type I CG in our hospital from January 2015 to March 2019. In our study, all type I CGs were secondary to hematologic diseases, and monoclonal gammopathy of unknown significance was the most common primary disease, accounting for 48.9% (n = 22). Read More

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http://dx.doi.org/10.1007/s00277-020-04123-1DOI Listing

Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar).

Intern Emerg Med 2020 Jun 10. Epub 2020 Jun 10.

Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.

Rituximab (RTX) represents a milestone in the treatment of mixed cryoglobulinemic vasculitis (MCV). Despite usually well-tolerated, RTX may induce different types of adverse drug reactions, including exacerbation of vasculitis. Recently, RTX biosimilar CT-P10 has been approved in Europe for the treatment of rheumatoid arthritis, but no data are available about effectiveness and safety of CT-P10 in the treatment of MCV. Read More

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http://dx.doi.org/10.1007/s11739-020-02386-0DOI Listing

Cryoglobulinemia after the era of chronic hepatitis C infection.

Semin Arthritis Rheum 2020 May 26;50(4):695-700. Epub 2020 May 26.

Sorbonne Université, UPMC Univ Paris 06, UMR 7211, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France, CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France; Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires et de l'Amylose, France. Electronic address:

Objectives: Historically chronic hepatitis C virus (HCV) infection accounted for the majority of mixed cryoglobulinemia (MC). The advent of direct-acting antivirals (DAA) against HCV has dramatically changed the management and the prevalence of chronic HCV infection. We aimed to describe the spectrum of MC in the era of DAA agents. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.004DOI Listing

Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report.

New Microbiol 2020 Jun;43(2):99-102

Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.

Cryptococcus species is still a very common opportunistic infection in AIDS patients. However, it is increasingly responsible for disease in otherwise immunocompromised individuals, such as transplant recipients and the heterogeneous group of patients with underlying immunologic diseases, hematologic disorders and organ failure syndromes. Clinical presentation, prognosis, and outcomes are difficult to define given these varied host groups, and tailoring treatments to fit the necessities of each patient is likewise challenging. Read More

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A case of glomerulonephritis caused by brucellosis.

Authors:
Emine Parlak

Trop Doct 2020 Jun 6:49475520929505. Epub 2020 Jun 6.

Department of Infectious Diseases and Clinical Microbiology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Brucellosis is the most common zoonosis in the world. It can affect several organs or systems, of which the genitourinary is the second most common after the musculoskeletal. Renal involvement in brucellosis takes the form of IgA nephropathy, interstitial nephritis, pyelonephritis, mixed cryoglobulinemia and kidney failure. Read More

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http://dx.doi.org/10.1177/0049475520929505DOI Listing

Membranoproliferative Glomerulonephritis and Mixed Cryoglobulinemia as a Form of Presentation of Visceral Leishmaniasis.

Am J Case Rep 2020 May 27;21:e921445. Epub 2020 May 27.

Department of Nephrology, Virgin Health Hospital, Toledo, Spain.

BACKGROUND Visceral leishmaniasis (VL) is an endemic systemic disease in the Mediterranean countries, including Spain. This vector-borne infection can present with several clinical presentations, from asymptomatic to severe forms. Renal impairment is frequently described in VL but is usually mild and related to interstitial nephritis, being that glomerular involvement is rarely found. Read More

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http://dx.doi.org/10.12659/AJCR.921445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274496PMC

Severe diffuse alveolar hemorrhage related to autoimmune disease: a multicenter study.

Crit Care 2020 05 18;24(1):231. Epub 2020 May 18.

Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DHU i2B), UPMC Université Paris 06, UMR 7211, Sorbonne Universités, 75005, Paris, France.

Background: Diffuse alveolar hemorrhage (DAH) occurs during the course of autoimmune disease and may be life threatening. The objective was to assess characteristics and prognosis factors of DAH who required intensive care unit (ICU) admission in patients with autoimmune diseases.

Methods: French multicenter retrospective study including patients presenting DAH related to autoimmune diseases requiring ICU admission from 2000 to 2016. Read More

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http://dx.doi.org/10.1186/s13054-020-02936-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236262PMC

Small Fiber Neuropathy: Clinicopathological Correlations.

Behav Neurol 2020 2;2020:8796519. Epub 2020 Jan 2.

Department of Neurology, University of Pécs, Medical School, Pécs, Hungary.

Small fiber neuropathy develops due to the selective damage of the thin fibers of peripheral nerves. Many common diseases can cause this condition, including diabetes, infections, autoimmune and endocrine disorders, but it can occur due to genetic alterations, as well. Eighty-five skin biopsy-proven small-fiber neuropathy cases were analyzed. Read More

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http://dx.doi.org/10.1155/2020/8796519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199601PMC
January 2020

Coexistence of antiphospholipid syndrome and cryoglobulinemia in a patient with rheumatoid arthritis.

Clin Rheumatol 2020 May 9. Epub 2020 May 9.

Rheumatology Department, Hospital Clinic of Barcelona, Villarroel 170, 08036, Barcelona, Spain.

We present here a case of severe digital necrosis in a patient with long-standing rheumatoid arthritis (RA). The concomitant presence of two autoimmune conditions such as cryoglobulinemia and antiphospholipid syndrome (APS) were diagnosed. To best of our knowledge, this is the first case of the coexistence of RA, cryoglobulinemia, and APS in a single patient. Read More

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http://dx.doi.org/10.1007/s10067-020-05127-yDOI Listing

A Detailed Analysis of the Distribution, Morphology, and Histopathology of Complex Purpura in Hospitalized Patients: A Case Series of 68 Patients.

J Am Acad Dermatol 2020 May 3. Epub 2020 May 3.

Yale School of Medicine Department of Dermatology and; Department of Pathology, New Haven, Connecticut. Electronic address:

Background: Purpura in inpatients commonly leads to dermatologic consultation. The differential diagnosis is broad and algorithms are intricate.

Objective: We evaluated inpatient consultations for complex purpura to document the most common diagnoses and to validate the true diagnostic utility of histopathology, clinical morphology, and distribution. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.149DOI Listing

Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report.

New Microbiol 2019 Dec 13;43(1). Epub 2019 Dec 13.

Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.

Cryptococcus species is still a very common opportunistic infection in AIDS patients. However, it is increasingly responsible for disease in otherwise immunocompromised individuals, such as transplant recipients and the heterogeneous group of patients with underlying immunologic diseases, hematologic disorders and organ failure syndromes. Clinical presentation, prognosis, and outcomes are difficult to define given these varied host groups, and tailoring treatments to fit the necessities of each patient is likewise challenging. Read More

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December 2019

Biomarkers of minimal residual disease in rituximab-treated patients with mixed cryoglobulinemia.

Biotechnol Appl Biochem 2020 Apr 25. Epub 2020 Apr 25.

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Hepatitis C virus (HCV) represents the major risk factor for mixed cryoglobulinemia (MC), a small-vessel vasculitis that may evolve into an overt B-cell non-Hodgkin's lymphoma. Here, we aimed to identify a biomarker signature for the early diagnosis of minimal residual disease (MRD). We assessed free light chains (FLCs), IgM k,and IgM λ heavy/light chain (HLC) pairs, and vascular endothelial growth factor (VEGF) in sera from 34 patients with MC vasculitis (32 HCV- and 2 HBV-related), treated with low-dose rituximab (RTX). Read More

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http://dx.doi.org/10.1002/bab.1929DOI Listing
April 2020
1.362 Impact Factor

A rare case of Waldenström's macroglobulinaemia-associated cryoglobulinaemia vasculitis.

Neth J Med 2020 03;78(2):83-86

Departement of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands.

This case report presents a patient with vasculitis as a presenting symptom of type I cryoglobulinaemia due to lymphoproliferative disease. This is an uncommon cause of vasculitis, but important to recognise, as it influences treatment decisions. We discuss the differential diagnosis and extensive diagnostic approach of vasculitis. Read More

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Remarkable pseudoleucocytosis induced by mild cryoglobulinemia.

Clin Chem Lab Med 2020 Apr 9. Epub 2020 Apr 9.

Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, P.R. China, Phone: +86 25 68303456.

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http://dx.doi.org/10.1515/cclm-2020-0148DOI Listing

Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors.

Adv Exp Med Biol 2020 Mar 18. Epub 2020 Mar 18.

Department of Biological Science and Technology, Tokyo University of Science, Tokyo, Japan.

Rheumatoid factors (RFs) are autoantibodies that recognize the fragment crystallizable (Fc) region of immunoglobulin G (IgG). Genetically diverse RFs are produced in rheumatoid arthritis patients; however, in hematologic diseases, such as cryoglobulinemia and B cell lymphoma, RFs from a limited combination of heavy chain V-region genes and J-region genes are produced in large quantities and forms immune complexes with IgG. These genetically limited RFs have historically been used for the immunochemical characterization of RFs. Read More

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http://dx.doi.org/10.1007/5584_2020_510DOI Listing

Rheumatologic manifestations during chronic viral hepatitis C.

Tunis Med 2019 Nov;97(11):1251-1257

Introduction: Chronic hepatitis C (CHC) is assimilated to a systemic disease because of its multiple extrahepatic manifestations particularly rheumatological.

Aim: To determine the prevalence and the characteristics of rheumatological manifestations (RM) associated with CHC.

Methods: a retrospective study including all patients suffering from CHC followed over a period of 11 years (2002 - 2012) at the department of gastroenterology B at La Rabta hospital. Read More

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November 2019

Leishmaniasis with cryoglobulinaemia and Leishmania infantum in peripheral blood neutrophils.

Br J Haematol 2020 Jun 9;189(5):801. Epub 2020 Mar 9.

Pathophysiology Department, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1111/bjh.16538DOI Listing

Graves' disease: Epidemiology, genetic and environmental risk factors and viruses.

Best Pract Res Clin Endocrinol Metab 2020 Jan 4;34(1):101387. Epub 2020 Feb 4.

Department of Translational Research of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

Graves' disease (GD) is the most common cause of hyperthyroidism in developed Countries. It is more common between 30 and 60 years; 5-10 times more frequent in women. The genetic predisposition accounts for 79% of the risk for GD, while environmental factors for 21%. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101387DOI Listing
January 2020

An update to the pathogenesis for monoclonal gammopathy of renal significance.

Ann Hematol 2020 Apr 26;99(4):703-714. Epub 2020 Feb 26.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Donghu District, Nanchang, 330006, China.

Monoclonal gammopathy of renal significance (MGRS) is characterized by the nephrotoxic monoclonal immunoglobulin secreted by an otherwise asymptomatic or indolent B cell or plasma cell clone, without hematologic criteria for treatment. These MGRS-associated diseases can involve one or more renal compartments, including glomeruli, tubules, and vessels. Hydrophobic residue replacement, N-glycosylated, increase in isoelectric point in monoclonal immunoglobulin (MIg) causes it to transform from soluble form to tissue deposition, and consequently resulting in glomerular damage. Read More

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http://dx.doi.org/10.1007/s00277-020-03971-1DOI Listing

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.

Cell 2020 03 13;180(5):878-894.e19. Epub 2020 Feb 13.

The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia. Electronic address:

Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies responsible for mixed cryoglobulinemic vasculitis. By combining single-cell DNA and RNA sequencing with serum antibody peptide sequencing and antibody synthesis, rare circulating B lymphocytes making pathogenic autoantibodies were found to comprise clonal trees accumulating mutations. Read More

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http://dx.doi.org/10.1016/j.cell.2020.01.029DOI Listing

Temperature-dependent cryoglobulin crystal transformation in peripheral blood.

Authors:
Fei Wang Geng Wang

Blood 2020 01;135(4):297

Peking Union Medical College Hospital.

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http://dx.doi.org/10.1182/blood.2019003763DOI Listing
January 2020

Rheumatoid factor-producing CD21low anergic clonal B-cells in essential mixed cryoglobulinaemia: a model for autoantigen-driven pathogenesis of infectious and non-infectious cryoglobulinaemias.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):139-147. Epub 2020 Jan 14.

Department of Translational and Precision Medicine, Sapienza University of Rome, and Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy.

Objectives: Essential mixed cryoglobulinaemia (EMC) is a disorder of B-cells producing rheumatoid factor (RF), and is clinically and immunologically similar to mixed cryoglobulinaemia (MC) related to hepatitis C virus (HCV-MC). We report here the first comprehensive analysis of B-cell clonality, phenotype and function in EMC.

Methods: The study population included 16 patients with EMC and 24 patients with HCV-MC. Read More

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January 2020

Hepatitis A Virus Infection Associated with Cryoglobulinemic Vasculitis.

Indian Pediatr 2020 01;57(1):71-72

Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, City of Marrakesh, Morocco.

Atypical symptoms, especially immune complex disorders, are uncommonly reported with hepatitis A virus (HAV) infection. We report an 8-year-old child who contracted HAV infection complicated by cryoglobulinemic vasculitis, and responded well to oral steroids. HAV infection may be considered in the etiology of cryoglobulinemia in children. Read More

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January 2020

The aggregation between AITD with rheumatologic, or dermatologic, autoimmune diseases.

Best Pract Res Clin Endocrinol Metab 2019 12 11;33(6):101372. Epub 2019 Dec 11.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address:

Autoimmune thyroid diseases (AITD) are organ-specific autoimmune disorders mediated by Th1 lymphocytes, whose main clinical presentations are Hashimoto's thyroiditis (HT), or Graves' disease (GD). HT, GD, thyroid autoantibodies and thyroid dysfunctions have been shown in systemic rheumatologic diseases (as Sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, or cryoglobulinemia). New associations of AITD with other autoimmune diseases are being discovered, for example with psoriatic arthritis and dermatological diseases. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101372DOI Listing
December 2019

Simultaneous tubular and glomerular involvement with cryoglobulinemia vasculitis in multiple myeloma.

Saudi J Kidney Dis Transpl 2019 Nov-Dec;30(6):1470-1474

Department of Nephrology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Renal manifestations in myeloma are varied. Tubulopathic light chains cause cast nephropathy or proximal tubulopathy, usually associated with tubulointerstitial nephritis. Glomerular involvement includes amyloidosis and monoclonal immunoglobulin deposition diseases. Read More

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http://dx.doi.org/10.4103/1319-2442.275496DOI Listing
January 2020

A practical guide to laboratory investigations at diagnosis and follow up in Waldenström macroglobulinaemia: recommendations from the Medical and Scientific Advisory Group, Myeloma Australia, the Pathology Sub-committee of the Lymphoma and Related Diseases Registry and the Australasian Association of Clinical Biochemists Monoclonal Gammopathy Working Group.

Pathology 2020 Feb 3;52(2):167-178. Epub 2020 Jan 3.

Department of Haematology, ACT Pathology, Canberra Hospital, ACT, Australia; ANU Medical School, College of Medicine and Health, Australian National University, Canberra, ACT, Australia; Medical and Scientific Advisory Group, Myeloma Australia; Pathology Sub-committee of the Lymphoma and Related Diseases Registry (LaRDR), Australia. Electronic address:

Waldenström macroglobulinaemia (WM) is an indolent non-Hodgkin lymphoma which usually presents with symptoms related to infiltration of bone marrow or other tissues like lymph nodes, liver or spleen and has certain unusual clinical manifestations, e.g., renal and central nervous system (CNS) involvement. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.11.002DOI Listing
February 2020
2.188 Impact Factor

The color of skin: purple diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):528-547. Epub 2019 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vessel vasculitis, immunoglobulin A (IgA) vasculitis, cryoglobulinemia, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosum, warfarin-induced skin necrosis, heparin-induced thrombocytopenia, purpura fulminans, antiphospholipid antibody syndrome, calciphylaxis, levamisole-induced vasculopathy, and thrombotic thrombocytopenic purpura. Dermatologists play a central role in treating patients with cutaneous vasculitis and vasculopathy and may have the opportunity to facilitate identification of systemic disease by diagnosing cutaneous vasculitis and vasculopathy. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.016DOI Listing

Development of Central Nervous System Vasculitis in a Patient with Waldenstrom Macroglobulinemia: A Rare Presentation with Poor Prognosis.

Cureus 2019 Oct 30;11(10):e6039. Epub 2019 Oct 30.

Pulmonary and Critical Care Medicine, Robert Packer Hospital, Sayre, USA.

Waldenstrom macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by the presence of monoclonal immunoglobulin M in serum. WM may present with neurologic complications involving the peripheral and central nervous systems (CNS) though CNS complications associated with WM are rare. We present a case of a 72-year-old male with an 18-month history of WM who experienced neurologic and constitutional symptoms indicative of WM progression over a three-week period while on rituximab maintenance therapy. Read More

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http://dx.doi.org/10.7759/cureus.6039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886659PMC
October 2019

Cutaneous manifestations of HAV, HBV, HCV.

G Ital Dermatol Venereol 2019 Dec 4. Epub 2019 Dec 4.

DISSAL, Department of Dermatology, Ospedale Policlinico San Martino, Genoa, Italy.

Hepatotropic viral infections are a relevant global health problem and present multiple extrahepatic manifestations in addition to hepatic disease. Along with generic cutaneous symptoms correlated to the cholestatic liver disease that may arise during the infection, some cutaneous manifestations of hepatotropic viral infections are characteristic, enabling to suspect the underlying infection. This review will present the principal cutaneous manifestations of hepatotropic virus infection. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06488-5DOI Listing
December 2019

Impact of mixed cryoglobulinemia on patients with spontaneous hepatitis C virus clearance: A 13-year prospective cohort study.

Eur J Clin Invest 2020 Jan 26;50(1):e13189. Epub 2019 Dec 26.

Division of Hepatology, Department of Gastroenterology and Hepatology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: The prevalence and associations of mixed cryoglobulinemia (MC) in patients with spontaneous clearance of hepatitis C virus (HCV) remain elusive.

Materials And Methods: A 13-year prospective cohort study of patients with spontaneous HCV clearance was conducted in a tertiary care centre. Baseline characteristics, incident cardiovascular and neurologic events and cancers were analysed. Read More

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http://dx.doi.org/10.1111/eci.13189DOI Listing
January 2020

Positive acute viral infection markers, autoimmune disease and type II mixed cryoglobulinemia: a rare concurrence.

BMJ Case Rep 2019 Nov 28;12(11). Epub 2019 Nov 28.

Catholic Health System Internal Medicine Training Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Cryoglobulins are abnormal serum immunoglobulins that tend to precipitate in intravascular compartments at temperatures lower than 37°C causing blood flow restriction to vital organs. They are divided into type I, II and III based on the immunoglobulin subtypes of the cryoprecipitates. Type II cryoglobulinemia is most commonly associated with viral infections, autoimmune diseases and lymphoproliferative disorders. Read More

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http://dx.doi.org/10.1136/bcr-2019-230492DOI Listing
November 2019

Understanding the Cryoglobulinemias.

Curr Rheumatol Rep 2019 11 19;21(11):60. Epub 2019 Nov 19.

Departamento de Inmunología clínica y Reumatología, Pontificia Universidad Católica de Chile, Diagonal Paraguay, #362, Santiago, Chile.

Purpose Of The Review: Cryoglobulins are immunoglobulins with the ability to precipitate at temperatures <37 °C. They are related to hematological disorders, infections [especially hepatitis C virus (HCV)], and autoimmune diseases. In this article, the state of the art on Cryoglobulinemic Vasculitis (CV), in a helpful and schematic way, with a special focus on HCV related Mixed Cryoglobulinemia treatment are reviewed. Read More

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http://dx.doi.org/10.1007/s11926-019-0859-0DOI Listing
November 2019

A Recurrent Case of Cryoglobulin-related Leukocytoclastic Vasculitis with an Unexpected Etiology.

Cureus 2019 Sep 27;11(9):e5783. Epub 2019 Sep 27.

Hospital Medicine, Aspirus Riverview Hospital, Wisconsin Rapids , USA.

We report a 64-year-old man presenting with cutaneous leukocytoclastic vasculitis, the underlying etiology of which was established as hepatitis C infection with associated cryoglobulinemia. This pathophysiologic state presented clinically as recurrent cutaneous vasculitic eruptions with the absence of any other clinical manifestations except for mild ankle swelling and weakness. This case clearly relates the need to consider hepatitis C as a potential etiologic factor in all patients with cutaneous vasculitis, and we suggest that viral hepatitis screening should be done routinely in all patients presenting with cutaneous vasculitis. Read More

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http://dx.doi.org/10.7759/cureus.5783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825495PMC
September 2019

Successful evolution of morphea after hepatitis C virus eradication with direct-acting antiviral agent treatment.

Rev Esp Enferm Dig 2019 12;111(12):973

Aparato Digestivo, Hospital Universitario Fundación Alcorcón , España.

Hepatitis C virus infection has been associated with many dermatologic conditions such as lichen planus, porphyria cutanea tarda, and cryoglobulinemia. Recently, an association of HCV with systemic sclerosis has been reported. However, there are few reports of the association of localized scleroderma or morphea with Hepatitis C Virus infection. Read More

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http://dx.doi.org/10.17235/reed.2019.6461/2019DOI Listing
December 2019

Type II mixed cryoglobulinemia following influenza and pneumococcal vaccine administration.

JAAD Case Rep 2019 Nov 24;5(11):960-962. Epub 2019 Oct 24.

Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.

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http://dx.doi.org/10.1016/j.jdcr.2019.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820236PMC
November 2019

Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study.

World J Gastroenterol 2019 Oct;25(40):6094-6106

Department of Medicine, University of Udine, Udine 33100, Italy.

Background: Direct-acting antiviral agents (DAAs) are extremely effective in eradicating hepatitis C virus (HCV) in chronically infected patients. However, the protective role of the sustained virologic response (SVR) achieved by second- and third-generation DAAs against the onset of hepatocellular carcinoma (HCC) and mortality is less well established.

Aim: To examine the occurrence of HCC or death from any cause in a retrospective-prospective study of patients treated with DAAs. Read More

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http://dx.doi.org/10.3748/wjg.v25.i40.6094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824275PMC
October 2019