4,564 results match your criteria Cryoglobulinemia


Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy.

Indian J Nephrol 2018 Nov-Dec;28(6):462-464

Department of Nephrology, Institute of Liver and Biliary Sciences, New Delhi, India.

Hepatitis C virus (HCV) infection has been shown to affect kidneys with various histopathological pattern on the kidney biopsy. These commonly include a membranoproliferative glomerulonephritis (MPGN) pattern with mixed cryoglobulinemia (CG), thrombotic microangiopathy, membranous nephropathy, and vasculitis affecting medium and small vessels of the kidneys causing polyarteritis nodosa. It has been rarely associated with MPGN without detectable CG. Read More

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http://dx.doi.org/10.4103/ijn.IJN_235_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309397PMC
January 2019

The complexity of an overlap type resistant cryoglobulinemia: a case report and review of the literature.

Clin Rheumatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine C, Wolfson Medical Center, 61 Halochamim Street, 58100, Holon, Israel.

Type I cryoglobulinemia is associated with B cell proliferative diseases, whereas essential mixed cryoglobulinemia is classically associated with infections, malignancy, and autoimmune diseases, but may be idiopathic. Prognosis in patients with grave manifestations and renal involvement is often poor. We report a case of a 40-year-old woman, 2 weeks post-partum for pre-eclampsia who was hospitalized with nephritic syndrome and acute renal failure. Read More

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http://dx.doi.org/10.1007/s10067-018-04423-yDOI Listing
January 2019

Improvement in Waldenström's Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals.

Ann Hepatol 2018 Oct;17(6):1072-1077

Gastroenterology Unit, Ospedale Policlinico San Martino, IRCCS per l'Oncologia, University of Genoa, Genoa, Italy.

Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin's Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antiviral treatment may be effective in inducing HCV-associated lymphoma regression. The recent advent of direct acting antivirals (DAAs) in the therapeutic armamentarium of HCV infection made possible treatment of patients with advanced liver disease. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7208DOI Listing
October 2018
1 Read

Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4.

Iran J Kidney Dis 2018 Nov;12(6):382-384

Urology and Nephrology Center, Mansoura University, Egypt.

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Read More

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November 2018
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Comment on: type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration.

Authors:
Mathew Sheridan

Br J Haematol 2018 Nov 22. Epub 2018 Nov 22.

Bristol Haematology and Oncology Centre, Bristol, UK.

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http://dx.doi.org/10.1111/bjh.15635DOI Listing
November 2018
1 Read

Serological profile of asymptomatic HCV positive patients with low level of cryoglobulins.

Biofactors 2018 Dec 18. Epub 2018 Dec 18.

Dipartimento di Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

Clinical spectrum of hepatitis C virus (HCV)-related cryoglobulinemia varies from an asymptomatic presentation to severe vasculitis and lymphoma. A recent study in HCV-negative patients suggests that low cryoglobulins (CGs) levels are responsible for severe renal and neurological complications. The aim of this study was to identify a panel of serological biomarkers associated with low levels of CGs in HCV-positive patients. Read More

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http://doi.wiley.com/10.1002/biof.1485
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http://dx.doi.org/10.1002/biof.1485DOI Listing
December 2018
5 Reads

[Hemodialysis treatment as a trigger cause of cryoglobulinemic purpura: a case report].

G Ital Nefrol 2018 Dec;35(6)

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, ROMA.

We describe the clinical case of a patient who developed mixed cryoglobulinemia syndrome after hemodialysis treatment with dialysate temperature lower than 36°C despite the negativization of the viral genome for HCV after eradication therapy. Read More

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December 2018
1 Read

The association of hepatitis C infection with the onset of CKD and progression into ESRD.

Semin Dial 2018 Nov 29. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated atherosclerosis, insulin resistance, and chronic inflammation. Read More

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http://doi.wiley.com/10.1111/sdi.12759
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http://dx.doi.org/10.1111/sdi.12759DOI Listing
November 2018
15 Reads

Expert opinion on managing chronic HCV in patients with mixed cryoglobulinaemia vasculitis.

Antivir Ther 2018 ;23(Suppl 2):1-9

Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France.

Mixed cryoglobulinaemia vasculitis (CryoVas) is a small-vessel systemic vasculitis caused by deposition of mixed cryoglobulins and is characterized by a wide range of clinical symptoms. HCV is the primary cause of CryoVas, which is associated with significant morbidity and mortality. The mortality rate among patients with HCV-associated CryoVas is 3× that of the general population, with a 63% 10-year survival rate. Read More

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https://www.intmedpress.com/journals/avt/abstract.cfm?id=324
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http://dx.doi.org/10.3851/IMP3246DOI Listing
January 2018
7 Reads

Clinical practice: hepatitis C virus infection, cryoglobulinemia and cryoglobulinemic vasculitis.

Clin Exp Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari "Aldo Moro", Polyclinic, Piazza G. Cesare, 11, 70124, Bari, Italy.

Cryoglobulins are circulating immunoglobulins that reversibly precipitate at temperatures below 37 °C. Type-II cryoglobulins consist of monoclonal IgM/polyclonal IgG immune complexes (ICs), whereas in type-III cryoglobulins both IgM and IgG are polyclonal. The clinical condition resulting from the presence of cryoglobulins in the blood is called mixed cryoglobulinemia (MC), which can be asymptomatic or manifest as cryoglobulinemic vasculitis (CV). Read More

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http://link.springer.com/10.1007/s10238-018-0536-z
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http://dx.doi.org/10.1007/s10238-018-0536-zDOI Listing
November 2018
9 Reads

Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?

World J Gastroenterol 2018 Nov;24(41):4617-4621

Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, University of Campania "L. Vanvitelli", Naples 80138, Italy.

Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, among these there is an increased risk of atherosclerosis and cardiovascular disease as well as an increased cardiovascular mortality. Several direct and indirect HCV pro-atherogenic mechanisms have been proposed. HCV lives and replicates within carotid plaques, promoting a local environment of pro-atherogenic factors. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i41/4617.htm
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http://dx.doi.org/10.3748/wjg.v24.i41.4617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224469PMC
November 2018
12 Reads

Interleukin-17A and B-cell activating factor in chronic hepatitis C patients with or without asymptomatic mixed cryoglobulinemia: effects of antiviral treatment and correlations with vitamin D.

Ann Gastroenterol 2018 Nov-Dec;31(6):705-711. Epub 2018 Sep 14.

2nd Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.

Background: Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating factor (BAFF) in MC has been described, but the role of interleukin (IL)-17A is less clear.

Methods: Serum concentrations of IL-17A, BAFF and 25-OH vitamin D were measured in CHC patients at baseline, end of treatment, and 6 months post-treatment with pegylated interferon-α and ribavirin, versus 12 healthy controls. Read More

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http://www.annalsgastro.gr/index.php/annalsgastro/article/do
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http://www.annalsgastro.gr/files/journals/1/earlyview/2018/e
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http://dx.doi.org/10.20524/aog.2018.0310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191865PMC
September 2018
3 Reads

Hepatitis C virus infection could affect the pathogenesis of ischemic heart diseases in northern Japan.

Hepatol Res 2018 Oct 30. Epub 2018 Oct 30.

Department of Hepatology, Sendai Kousei Hospital, Sendai, Japan.

Aims: Previously, our group reported that lymphotropic hepatitis C virus (HCV) could induce various kinds of immune dysfunctions. The immune dysfunctions could cause vascular disease by inducing cryoglobulinemia. It has been reported that ischemic heart diseases might be caused by HCV. Read More

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http://dx.doi.org/10.1111/hepr.13283DOI Listing
October 2018
3 Reads

Comment on: Type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration.

Authors:
Utku Iltar

Br J Haematol 2018 Oct 29. Epub 2018 Oct 29.

Department of Haematology, Antalya Training and Research Hospital, Antalya, Turkey.

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http://dx.doi.org/10.1111/bjh.15636DOI Listing
October 2018
1 Read

Incidence and Characteristics of de novo Renal Cryoglobulinemia After Direct-Acting Antivirals Treatment in an Egyptian Hepatitis C Cohort.

Nephron 2018 25;140(4):275-281. Epub 2018 Oct 25.

Department of Internal Medicine, Nephrology Unit, School of Medicine, Cairo University, Cairo, Egypt.

Introduction: The side effects profile of the new direct--acting antivirals for the treatment of hepatitis C virus (HCV) is not fully elucidated.

Objective: In this cross-sectional study, we aim to describe the incidence and characteristics of a novel observation of de novo renal cryoglobulinemic glomerulonephritis after successful treatment with DAA.

Methodology: A total of 12,985 Hepatitis C Patients (genotype IV) received the new DAA. Read More

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http://dx.doi.org/10.1159/000493807DOI Listing
October 2018
1 Read

Uncommon immune-mediated extrahepatic manifestations of HCV infection.

Expert Rev Clin Immunol 2018 Dec 26;14(12):1089-1099. Epub 2018 Oct 26.

a Division of Internal Medicine, Department of Medical and Surgical Sciences , "Luigi Vanvitelli" University of Campania , Naples , Italy.

Introduction: Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1538790DOI Listing
December 2018
1 Read

[Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene].

Arkh Patol 2018 ;80(5):40-45

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper describes a case of essential cryoglobulinemia unassociated with hepatitis B and C viruses. The morphological substrate of the disease was exclusively proliferative endothrombovasculitis without destructive changes in the walls of affected vessels. In addition, in the late stage of the disease, there was its unusual manifestation associated with inflammation of the mesentery arteriolar walls and with the formation of occlusive blood clots in their lumens, which led to severe abdominal diseases. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/5/dow
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http://dx.doi.org/10.17116/patol20188005140DOI Listing
January 2018
6 Reads

Persistence of Pathogenic B-Cell Clones and Relapse of Cryoglobulinemic Vasculitis in HCV-Cured Patients.

Gastroenterology 2019 01 10;156(1):291. Epub 2018 Oct 10.

Department of Clinical Medicine, Laboratory Affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183515
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http://dx.doi.org/10.1053/j.gastro.2018.06.094DOI Listing
January 2019
1 Read

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis-A Case Report with Literature Review.

Case Rep Med 2018 13;2018:3625139. Epub 2018 Sep 13.

Internal Medicine Department, Beaumont Hospital, Royal Oak, MI, USA.

Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain-Barre syndrome, and pleural or pericardial effusion. Read More

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http://dx.doi.org/10.1155/2018/3625139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158949PMC
September 2018
4 Reads

IgG cryoglobulinemia.

Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6057-6062

Clinical Pathology Laboratory, Ospedale Madre Giuseppina Vannini, Rome, Italy.

Objective: Mixed Cryoglobulinemia is the most well-known Hepatitis C Virus (HCV)-associated extrahepatic manifestation. MC is both an autoimmune and B-lymphoproliferative disorder. Cryoglobulins (CGs) are classified into three groups according to immunoglobulin (Ig) composition: type I is composed of one isotype or Ig class. Read More

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http://dx.doi.org/10.26355/eurrev_201809_15943DOI Listing
September 2018
13 Reads

A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12355

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro" Medical School.

Rationale: Type I cryoglobulinemia is a rare and life-threatening condition. It occurs mainly in B-cell lymphoproliferative disorder. In almost half of the patients, type I cryoglobulinemia is characterized by severe cutaneous involvement. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0003
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http://dx.doi.org/10.1097/MD.0000000000012355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181604PMC
September 2018
3 Reads

Autoimmune Kidney Diseases Associated with Chronic Viral Infections.

Rheum Dis Clin North Am 2018 11 7;44(4):675-698. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, GRB 7, Boston, MA 02114, USA. Electronic address:

Autoimmune kidney diseases triggered by viruses are an important cause of kidney disease in patients affected by chronic viral infection. Hepatitis B virus (HBV) infection is associated with membranous nephropathy and polyarteritis nodosa. Hepatitis C virus (HCV) infection is a major cause of cryoglobulinemic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.006DOI Listing
November 2018
1 Read

Renal complications of liver diseases.

Expert Rev Gastroenterol Hepatol 2018 Oct 1. Epub 2018 Oct 1.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation rénale, Grenoble-Alpes , France.

Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the major causes of chronic liver disease. HBV and HCV affect nearly 7% of the world's population. Extra-hepatic complications and particularly renal failure have different mechanisms and manifestations. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530984DOI Listing
October 2018
7 Reads

Editorial: interferon-free DAAs are a great boon for patients with hepatitis C and cryoglobulinaemia.

Aliment Pharmacol Ther 2018 Oct;48(7):770-771

The core Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/apt.14899DOI Listing
October 2018
2 Reads

Editorial: interferon-free DAAs are a great boon for patients with hepatitis C and cryoglobulinaemia-Authors' reply.

Aliment Pharmacol Ther 2018 Oct;48(7):772-773

Department of Experimental and Clinical Medicine and Department of Oncology, Interdepartmental Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy.

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http://dx.doi.org/10.1111/apt.14936DOI Listing
October 2018
2 Reads

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management.

Kidney Int 2018 Oct;94(4):663-673

Division of Hepatology, University of Miami, Miami, Florida, USA. Electronic address:

Infection with the hepatitis C virus (HCV) has adverse liver, kidney, and cardiovascular consequences in patients with chronic kidney disease (CKD), including those on dialysis therapy and in those with a kidney transplant. Since the publication of the original Kidney Disease: Improving Global Outcomes (KDIGO) HCV Guideline in 2008, major advances in HCV management, particularly with the advent of direct-acting antiviral therapies, have now made the cure of HCV possible in CKD patients. In addition, diagnostic techniques have evolved to enable the noninvasive diagnosis of liver fibrosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183044
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http://dx.doi.org/10.1016/j.kint.2018.06.011DOI Listing
October 2018
7 Reads

Apheresis treatment of cryoglobulinemic vasculitis: A multicentre cohort study of 159 patients.

Transfus Apher Sci 2018 Oct 26;57(5):639-645. Epub 2018 Jun 26.

Infectious Disease Unit, Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Italy. Electronic address:

Objective: To assess the effectiveness of apheresis therapy (AT) in treating the clinical manifestations of patients with complicated cryoglobulinemic vasculitis (CV).

Methods: A retrospective cohort study of 159 CV patients attending 22 Italian Centers who underwent at least one AT session between 2005 and 2015. The response to AT was evaluated on the basis of a defined grading system. Read More

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http://dx.doi.org/10.1016/j.transci.2018.06.005DOI Listing
October 2018
5 Reads

Correlation of CCR5 and NLRP3 gene polymorphisms with renal damage due to hepatitis C virus-related cryoglobulinemia.

Exp Ther Med 2018 Oct 1;16(4):3055-3059. Epub 2018 Aug 1.

Department of Infectious Disease, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Correlation of C-C chemokine receptor type 5 (CCR5) and NACHT, LRR and PYD domain-containing protein 3 (NLRP3) gene polymorphisms with renal damage due to hepatitis C virus (HCV)-related cryoglobulinemia were investigated. The 1:1 matched case-control study design was adopted, 171 patients with renal damage due to HCV-related cryoglobulinemia were selected as the case group, and 171 patients without renal damage were selected as the control group. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect the polymorphisms of locus rs1799987A/G in CCR5 gene and locus rs35829419A/C in NLRP3 gene of 171 pairs of HCV patients. Read More

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http://dx.doi.org/10.3892/etm.2018.6558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125838PMC
October 2018
2 Reads

Mixed cryoglobulinemic membranoproliferative glomerulonephritis due to monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12416

Division of Nephrology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital.

Rationale: Membranoproliferative glomerulonephritis (MPGN) can be induced by autoimmune diseases, chronic infection, chronic hepatitis, and paraproteins (including cryoglobulinemia). In addition, the mixed cryoglobulinemic MPGN is reported to be highly correlated with hepatitis C virus (HCV) infection.

Patient Concerns: We reported a rare case of a 61-year-old woman without a history of viral hepatitis infection; she presented with bilateral leg edema and proteinuria. Read More

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http://dx.doi.org/10.1097/MD.0000000000012416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156052PMC
September 2018
1 Read

Staphylococcal Infection-Related Glomerulonephritis With Cryoglobulinemic Features.

Kidney Int Rep 2018 Sep 2;3(5):1128-1134. Epub 2018 Jun 2.

Department of Pathology, Sharp Memorial Hospital, San Diego, California, USA.

Introduction: Staphylococcal infection-related glomerulonephritis (GN) has been shown to represent a unique form of infection-related GN that contains IgA-dominant deposits and is often seen concurrently with the bacterial infection. Biopsies commonly reveal an endocapillary proliferative and/or exudative or mesangial proliferative GN. Rare cases have been reported to show cryoglobulin-like features, including hyaline pseudothrombi and wireloop deposits; however, detailed characterization of these cases is lacking. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127436PMC
September 2018
3 Reads

Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia.

Hematol Oncol 2018 Sep 7. Epub 2018 Sep 7.

Division of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Read More

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http://dx.doi.org/10.1002/hon.2539DOI Listing
September 2018
6 Reads

Initial Evaluation of the Patient with Waldenström Macroglobulinemia.

Hematol Oncol Clin North Am 2018 Oct 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.05.008DOI Listing
October 2018
3 Reads

Rituximab treatment for immune-complex-mediated membranoproliferative glomerulonephritis.

Immunotherapy 2018 Sep;10(12):1027-1031

Department of Nephrology, Peking University People's Hospital, Beijing,100044, China.

Immune-complex-mediated membranoproliferative glomerulonephritis (MPGN) is a new concept that refers to MPGN with immunoglobulin and C3 deposition in the kidney based on immunofluorescence examination. It is associated with pathological autoantibodies production. Rituximab, as an immunosuppressive agent, can eliminate B cells selectively. Read More

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http://dx.doi.org/10.2217/imt-2018-0031DOI Listing
September 2018
10 Reads

The evaluation of disease activity in Sjögren's syndrome based on the degree of MALT involvement: glandular swelling and cryoglobulinaemia compared to ESSDAI in a cohort study.

Clin Exp Rheumatol 2018 May-Jun;36 Suppl 112(3):150-156. Epub 2018 Aug 14.

Department of Medical and Biological Sciences, Rheumatology Clinic, University of Udine, Italy.

Objectives: To investigate if indicators of a heavier involvement of mucosa-associated lymphoid tissue (MALT) in primary Sjögren's syndrome (pSS), i.e. persistent salivary gland (SG) swelling and cryoglobulinaemia, might better evaluate the lymphoma risk compared to the ESSDAI. Read More

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November 2018
3 Reads

Bartonella Infectious Endocarditis Associated With Cryoglobulinemia and Multifocal Proliferative Glomerulonephritis.

Open Forum Infect Dis 2018 Aug 27;5(8):ofy186. Epub 2018 Jul 27.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

sp. are a common cause of culture-negative infective endocarditis. Glomerulonephritis is a well-documented consequence of the immune activation associated with infective endocarditis. Read More

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http://dx.doi.org/10.1093/ofid/ofy186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101537PMC
August 2018
2 Reads

Are direct-acting antivirals safe and effective in hepatitis C virus-cryoglobulinemia? virological, immunological, and clinical data from a real-life experience.

Eur J Gastroenterol Hepatol 2018 10;30(10):1208-1215

I Department of Infectious Diseases.

Objectives: Hepatitis C virus (HCV) is the major cause of cryoglobulinemia. Direct-acting antivirals (DAAs) have markedly changed the therapeutic outcomes in the treatment of patients with HCV. We evaluate the efficacy, safety, immunological, and clinical response of different DAA regimens in HCV-cryoglobulinemia. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001239DOI Listing
October 2018
12 Reads

Hepatitis C mixed cryoglobulinemia with undetectable viral load: A case series.

JAAD Case Rep 2018 Aug 15;4(7):684-687. Epub 2018 Aug 15.

Department of Dermatology, University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1016/j.jdcr.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098195PMC
August 2018
9 Reads

Cryoglobulin crystals in a patient with chronic lymphocytic leukaemia.

Pathology 2018 Oct 3;50(6):670-671. Epub 2018 Aug 3.

Department of Haematology, Royal North Shore Hospital, St Leonards, NSW, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.03.012DOI Listing
October 2018
1 Read

Cryoglobulinaemia.

Authors:

Nat Rev Dis Primers 2018 Aug 2;4(1):12. Epub 2018 Aug 2.

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http://dx.doi.org/10.1038/s41572-018-0015-6DOI Listing
August 2018
3 Reads

Cryoglobulinaemia.

Nat Rev Dis Primers 2018 Aug 2;4(1):11. Epub 2018 Aug 2.

Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, Modena, Italy.

Cryoglobulinaemia refers to the serum presence of cryoglobulins, which are defined as immunoglobulins that precipitate at temperatures <37 °C. Type I cryoglobulinaemia consists of only one isotype or subclass of monoclonal immunoglobulin, whereas type II and type III are classified as mixed cryoglobulinaemia because they include immunoglobulin G (IgG) and IgM. Many lymphoproliferative, infectious and autoimmune disorders have been associated with mixed cryoglobulinaemia; however, hepatitis C virus (HCV) is the aetiologic agent in most patients. Read More

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http://dx.doi.org/10.1038/s41572-018-0009-4DOI Listing
August 2018
4 Reads

Significance of mutations in the region coding for NS3/4 protease in patients infected with HCV genotype 1b.

Adv Clin Exp Med 2018 Nov;27(11):1593-1600

Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Poland.

Background: Fast hepatitis C virus (HCV) replication is one of the reasons for frequent changes in viral genome.

Objectives: The objective of this study was to evaluate the frequency and type of mutation in NS3/4 protease in patients with HCV genotype 1b and to determine the effect of the mutation on viral load, fibrosis stage, alanine aminotransferase (ALT) activity, and alpha-fetoprotein (AFP) level.

Material And Methods: The study included 46 treatment-naïve patients, infected with HCV genotype 1b. Read More

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http://dx.doi.org/10.17219/acem/75511DOI Listing
November 2018
2 Reads

On the origin of rheumatoid factors: Insights from analyses of variable region sequences.

Semin Arthritis Rheum 2018 Jun 24. Epub 2018 Jun 24.

Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, PO Box 9892, 1006 AN Amsterdam, The Netherlands. Electronic address:

Objectives: Rheumatoid factors (RFs) are thought to play an important role in rheumatoid arthritis (RA), but are also found in healthy donors (HDs). Previous studies examined variable region sequences of these autoantibodies at a time when knowledge of the human germline repertoire was incomplete. Here we collected and analyzed RF sequence data from the literature to elucidate how RFs develop and whether their characteristics differ between RA patients and HDs. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.06.006DOI Listing
June 2018
5 Reads

Radiation Therapy Induced Esophageal Ulcer.

S D Med 2018 Feb;71(2):81-84

Vassar Brother Medical Centre, Poughkeepsie, New York.

Dysproteinemia is excessive production of immunoglobulins from clonal proliferation of plasma or B cells. Cryoglobulins are a special group of immunoglobulins that precipitate below 37 degrees C. Type 1 cryoglobulinemia consists mostly of IgM and IgG that infrequently leads to glomerulonephritis. Read More

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February 2018
22 Reads

Proliferative glomerulonephritis with unusual microlamellar organized deposits related to monoclonal immunoglobulin G3 (IgG3) kappa.

CEN Case Rep 2018 Jul 9. Epub 2018 Jul 9.

Department of Nephrology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.

A 71-year-old woman presented with massive proteinuria and microhematuria. Renal biopsy showed diffuse global membranoproliferative and endocapillary proliferative lesions with leukocytic infiltration and an irregular duplication of the glomerular basement membrane on light microscopy. Immunofluorescence study showed granular deposits of monoclonal immunoglobulin G3 (IgG3) kappa, C3, and C1q in the glomeruli. Read More

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http://dx.doi.org/10.1007/s13730-018-0351-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181896PMC
July 2018
3 Reads

Successful renal transplantation to a recipient with type II cryoglobulinemia: a case report.

BMC Nephrol 2018 Jul 9;19(1):170. Epub 2018 Jul 9.

Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.

Background: Recurrence of glomerulonephritis is an important risk factor for renal graft dysfunction. Cryoglobulinemia is known as a relatively rare cause of renal failure, and doctors are usually hesitant to perform transplantation on a recipient with cryoglobulinemia because of the risk for graft loss. We present a case of renal transplantation on a patient with organ manifestations of type II cryoglobulinemia. Read More

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http://dx.doi.org/10.1186/s12882-018-0966-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038236PMC
July 2018
8 Reads

Sofosbuvir-daclatasvir improves hepatitis C virus-induced mixed cryoglobulinemia: Upper Egypt experience.

Infect Drug Resist 2018 27;11:895-901. Epub 2018 Jun 27.

Clinical Pathology Department, Faculty of Medicine Al-Azhar University (Assiut Branch), Assiut, Egypt.

Background And Aims: Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations such as cryoglobulinemia and accounts for up to 90% of all cases of mixed cryoglobulinemia (MC). The present study aimed to evaluate the effect of sofosbuvir-daclatasvir therapy on symptomatic HCV-related MC and sustained virologic response (SVR) achievement.

Patients And Methods: This prospective cohort study was carried out on 120 patients with chronic HCV infection, clinically suspected to have MC, but only 63 of whom were positive for cryoglobulins. Read More

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http://dx.doi.org/10.2147/IDR.S167093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027820PMC
June 2018
3 Reads

Persistent mixed cryoglobulinemia after successful antiviral treatment of chronic hepatitis C virus infection: What's the next?

Scand J Gastroenterol 2018 Jun - Jul;53(7):883-884. Epub 2018 Jul 2.

b Sechenov First Moscow State Medical University , Moscow , Russia.

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http://dx.doi.org/10.1080/00365521.2018.1477988DOI Listing
November 2018
4 Reads

Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature.

Indian J Nephrol 2018 May-Jun;28(3):229-231

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Monoclonal gammopathy of renal significance (MGRS) can present with myriad of morphological features. We report a case of MGRS in a 46-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. Renal biopsy showed amorphous eosinophilic periodic acid-Schiff positive deposits in capillary loops and lamda light chain positivity on immunofluorescence, suggestive of cyoglobulinemic glomerulonephritis. Read More

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http://dx.doi.org/10.4103/ijn.IJN_166_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998724PMC
July 2018
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Renal-limited Cryoglobulinemic Vasculitis: Two Case Reports.

Intern Med 2018 1;57(13):1879-1886. Epub 2018 Jul 1.

Nephrology Center, Toranomon Hospital, Japan.

Cryoglobulinemic vasculitis (CV) presents with systemic manifestations, including renal disease, arthritis, peripheral neuropathy, and muscle weakness. We encountered two patients who developed severe nephrotic range proteinuria; however, extrarenal manifestations were not noted during the clinical course. A renal biopsy revealed typical membranoproliferative glomerulonephritis (MPGN) with huge thrombus-like endothelial deposits and predominant IgM positivity, but electron microscopy did not reveal any definite microtubules. Read More

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http://dx.doi.org/10.2169/internalmedicine.0131-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064702PMC
October 2018
2 Reads

HCV-negative mixed cryoglobulinemia and kidney involvement: in-depth review on physiopathological and histological bases.

Clin Exp Med 2018 Nov 28;18(4):465-471. Epub 2018 Jun 28.

Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

Type II mixed cryoglobulinemia without evidence of HCV infection but rather with renal involvement has been occasionally described. The pathogenesis of cryoglobulinemic kidney disease is most likely related to immune complex deposition including cryoglobulins, and cryoaggregation after cold exposure could play a pivotal role in clinical expression of cryoglobulinemia. In these cases, acute kidney injury and proteinuria remain the most frequent clinical expression of a cryoglobulinemic glomerulonephritis. Read More

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http://dx.doi.org/10.1007/s10238-018-0514-5DOI Listing
November 2018
3 Reads